locus-tag	class	description
Xcom_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Xcom_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Xcom_00020	COG0187	DNA topoisomerase II activity
Xcom_00030	COG0501	Belongs to the peptidase M48B family
Xcom_00070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Xcom_00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Xcom_00120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Xcom_00125	COG0793	Belongs to the peptidase S41A family
Xcom_00130	COG4942	peptidase
Xcom_00140	COG2234	aminopeptidase activity
Xcom_00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Xcom_00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Xcom_00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Xcom_00190	COG0493	'glutamate synthase
Xcom_00195	COG0067	glutamate synthase
Xcom_00195	COG0070	glutamate synthase
Xcom_00195	COG0069	glutamate synthase activity
Xcom_00285	COG1111	helicase
Xcom_00285	COG1205	dead DEAH box helicase
Xcom_00290	COG1272	protein, Hemolysin III
Xcom_00310	COG0300	oxidoreductase activity
Xcom_00315	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_00335	COG3237	CsbD-like
Xcom_00380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Xcom_00390	COG0477	Major facilitator Superfamily
Xcom_00430	COG0714	Associated with various cellular activities
Xcom_00480	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Xcom_00490	COG4772	TonB-dependent receptor
Xcom_00510	COG1012	belongs to the aldehyde dehydrogenase family
Xcom_00535	COG1304	FMN binding
Xcom_00550	COG1755	Isoprenylcysteine carboxyl methyltransferase
Xcom_00555	COG4585	Histidine kinase
Xcom_00560	COG2197	response regulator
Xcom_00580	COG3710	Transcriptional regulator
Xcom_00585	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Xcom_00595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Xcom_00640	COG0366	Alpha amylase catalytic
Xcom_00645	COG0366	Alpha amylase catalytic
Xcom_00650	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Xcom_00665	COG2272	Belongs to the type-B carboxylesterase lipase family
Xcom_00670	COG0657	acetylesterase activity
Xcom_00670	COG2755	lipolytic protein G-D-S-L family
Xcom_00680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Xcom_00695	COG3507	Belongs to the glycosyl hydrolase 43 family
Xcom_00700	COG1609	Transcriptional regulator
Xcom_00705	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Xcom_00710	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_00720	COG2755	lipolytic protein G-D-S-L family
Xcom_00730	COG3186	Phenylalanine-4-hydroxylase
Xcom_00735	COG1522	sequence-specific DNA binding
Xcom_00745	COG1752	Esterase of the alpha-beta hydrolase superfamily
Xcom_00750	COG1473	amidohydrolase
Xcom_00760	COG1119	ATPase activity
Xcom_00775	COG0517	IMP dehydrogenase activity
Xcom_00775	COG1125	glycine betaine transport
Xcom_00790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Xcom_00825	COG0489	protein tyrosine kinase activity
Xcom_00830	COG2062	phosphohistidine phosphatase, SixA
Xcom_00840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Xcom_00885	COG1968	undecaprenyl-diphosphatase activity
Xcom_00895	COG0174	glutamine synthetase
Xcom_00900	COG0347	Belongs to the P(II) protein family
Xcom_00905	COG0004	ammonium transporteR
Xcom_00910	COG3852	Histidine kinase
Xcom_00915	COG2204	response regulator
Xcom_00920	COG2032	superoxide dismutase activity
Xcom_00925	COG2032	superoxide dismutase activity
Xcom_00935	COG0346	lactoylglutathione lyase activity
Xcom_00945	COG0183	Belongs to the thiolase family
Xcom_00980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Xcom_00985	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Xcom_00990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Xcom_01005	COG0028	Belongs to the TPP enzyme family
Xcom_01010	COG2205	protein histidine kinase activity
Xcom_01035	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Xcom_01050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Xcom_01055	COG3177	Filamentation induced by cAMP protein fic
Xcom_01060	COG0596	Alpha beta hydrolase
Xcom_01070	COG0318	PFAM AMP-dependent synthetase and ligase
Xcom_01075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Xcom_01085	COG1181	Belongs to the D-alanine--D-alanine ligase family
Xcom_01100	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Xcom_01110	COG0564	pseudouridine synthase activity
Xcom_01130	COG1446	asparaginase
Xcom_01135	COG0339	signal peptide processing
Xcom_01170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Xcom_01180	COG4221	oxidoreductase activity
Xcom_01185	COG0583	DNA-binding transcription factor activity
Xcom_01195	COG0477	Major facilitator Superfamily
Xcom_01200	COG1289	transmembrane transporter activity
Xcom_01210	COG1566	PFAM secretion protein HlyD family protein
Xcom_01225	COG0302	gtp cyclohydrolase
Xcom_01245	COG0730	response to heat
Xcom_01250	COG3012	SEC-C Motif Domain Protein
Xcom_01260	COG0676	glucose-6-phosphate 1-epimerase activity
Xcom_01280	COG3135	benzoate transporter
Xcom_01310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Xcom_01320	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Xcom_01330	COG1435	thymidine kinase activity
Xcom_01335	COG0210	DNA helicase
Xcom_01355	COG3132	Protein of unknown function, DUF480
Xcom_01365	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
Xcom_01370	COG0284	orotidine-5'-phosphate decarboxylase activity
Xcom_01405	COG2937	Belongs to the GPAT DAPAT family
Xcom_01415	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_01415	COG0604	alcohol dehydrogenase
Xcom_01415	COG3321	synthase
Xcom_01450	COG2211	Major facilitator Superfamily
Xcom_01465	COG3693	PFAM glycoside hydrolase, family 10
Xcom_01475	COG3693	PFAM glycoside hydrolase, family 10
Xcom_01480	COG1904	glucuronate isomerase
Xcom_01485	COG3250	beta-galactosidase activity
Xcom_01495	COG3386	PFAM SMP-30 Gluconolaconase
Xcom_01525	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Xcom_01580	COG0246	Mannitol dehydrogenase
Xcom_01585	COG1472	Belongs to the glycosyl hydrolase 3 family
Xcom_01595	COG4948	Mandelate Racemase Muconate Lactonizing
Xcom_01605	COG3661	Belongs to the glycosyl hydrolase 67 family
Xcom_01615	COG2115	Belongs to the xylose isomerase family
Xcom_01630	COG2974	May be involved in recombination
Xcom_01655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Xcom_01665	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Xcom_01670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Xcom_01675	COG0805	protein transport
Xcom_01685	COG0519	Catalyzes the synthesis of GMP from XMP
Xcom_01685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Xcom_01700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Xcom_01705	COG0752	glycyl-tRNA synthetase alpha subunit
Xcom_01720	COG0457	Tetratricopeptide repeat
Xcom_01725	COG4771	TonB-dependent receptor
Xcom_01730	COG0729	surface antigen
Xcom_01735	COG2911	Protein conserved in bacteria
Xcom_01755	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Xcom_01765	COG3265	gluconokinase activity
Xcom_01770	COG2211	Major facilitator Superfamily
Xcom_01775	COG3459	Glycosyltransferase 36 associated
Xcom_01790	COG2205	protein histidine kinase activity
Xcom_01795	COG1971	Probably functions as a manganese efflux pump
Xcom_01800	COG1414	Transcriptional regulator
Xcom_01805	COG0738	Major facilitator superfamily
Xcom_01810	COG3254	rhamnose metabolic process
Xcom_01815	COG4948	Mandelate Racemase Muconate Lactonizing
Xcom_01825	COG0179	Fumarylacetoacetate (FAA) hydrolase
Xcom_01830	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_01850	COG3507	Belongs to the glycosyl hydrolase 43 family
Xcom_01885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Xcom_01895	COG3162	membrane
Xcom_01900	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Xcom_01910	COG0708	Exodeoxyribonuclease III
Xcom_01925	COG2091	lysine biosynthetic process via aminoadipic acid
Xcom_01935	COG3540	Alkaline phosphatase
Xcom_01940	COG0357	Ribosomal RNA small subunit methyltransferase G
Xcom_01965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xcom_01980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Xcom_01985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Xcom_01995	COG2159	amidohydrolase
Xcom_02010	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Xcom_02015	COG0583	DNA-binding transcription factor activity
Xcom_02020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Xcom_02040	COG0210	DNA helicase
Xcom_02160	COG3501	Rhs element vgr protein
Xcom_02175	COG0583	DNA-binding transcription factor activity
Xcom_02180	COG0667	Aldo Keto reductase
Xcom_02205	COG0631	protein serine/threonine phosphatase activity
Xcom_02210	COG0515	serine threonine protein kinase
Xcom_02250	COG0408	coproporphyrinogen oxidase activity
Xcom_02300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Xcom_02315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Xcom_02345	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_02365	COG0463	Glycosyl transferase, family 2
Xcom_02380	COG3100	YcgL domain-containing protein
Xcom_02395	COG3387	PFAM Glycoside hydrolase 15-related
Xcom_02440	COG2239	Acts as a magnesium transporter
Xcom_02445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Xcom_02445	COG1042	CoA-binding domain protein
Xcom_02445	COG0045	succinate-CoA ligase (ADP-forming) activity
Xcom_02460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Xcom_02470	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Xcom_02475	COG0716	FMN binding
Xcom_02500	COG0732	type I restriction modification DNA specificity domain
Xcom_02505	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Xcom_02515	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
Xcom_02555	COG0328	RNA-DNA hybrid ribonuclease activity
Xcom_02555	COG0406	alpha-ribazole phosphatase activity
Xcom_02560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Xcom_02575	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_02585	COG3537	Alpha-1,2-mannosidase
Xcom_02595	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_02605	COG0492	ferredoxin-NADP+ reductase activity
Xcom_02650	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Xcom_02655	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Xcom_02660	COG2080	2 iron, 2 sulfur cluster binding
Xcom_02695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Xcom_02710	COG0587	DNA-directed DNA polymerase activity
Xcom_02730	COG1297	OPT oligopeptide transporter protein
Xcom_02750	COG0823	Involved in the tonB-independent uptake of proteins
Xcom_02750	COG1506	peptidase
Xcom_02765	COG1917	Cupin 2, conserved barrel domain protein
Xcom_02765	COG2207	Transcriptional regulator
Xcom_02790	COG0753	catalase activity
Xcom_02795	COG0656	L-ascorbic acid biosynthetic process
Xcom_02800	COG2272	Belongs to the type-B carboxylesterase lipase family
Xcom_02805	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Xcom_02805	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Xcom_02850	COG2194	sulfuric ester hydrolase activity
Xcom_02865	COG0745	RESPONSE REGULATOR receiver
Xcom_02870	COG0642	Histidine kinase
Xcom_02880	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Xcom_02885	COG2894	cell division
Xcom_02890	COG0850	regulation of cytokinetic process
Xcom_02905	COG4585	Histidine kinase
Xcom_02910	COG2197	response regulator
Xcom_02925	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Xcom_02955	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Xcom_02975	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Xcom_02990	COG1595	DNA-templated transcription, initiation
Xcom_03000	COG1946	Acyl-CoA thioesterase
Xcom_03005	COG1024	Enoyl-CoA hydratase
Xcom_03015	COG0824	Thioesterase
Xcom_03020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Xcom_03025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Xcom_03030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Xcom_03035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Xcom_03040	COG0268	Binds directly to 16S ribosomal RNA
Xcom_03045	COG0728	peptidoglycan biosynthetic process
Xcom_03050	COG0196	riboflavin kinase activity
Xcom_03055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Xcom_03060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Xcom_03065	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Xcom_03080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Xcom_03085	COG1845	cytochrome c oxidase, subunit III
Xcom_03090	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Xcom_03105	COG3152	Membrane
Xcom_03115	COG2207	Transcriptional regulator
Xcom_03120	COG0326	Molecular chaperone. Has ATPase activity
Xcom_03130	COG1366	Belongs to the anti-sigma-factor antagonist family
Xcom_03140	COG2172	sigma factor antagonist activity
Xcom_03165	COG4771	TonB-dependent receptor
Xcom_03175	COG5507	3-demethylubiquinone-9 3-methyltransferase
Xcom_03180	COG2205	protein histidine kinase activity
Xcom_03190	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Xcom_03195	COG3437	response regulator, receiver
Xcom_03195	COG2205	protein histidine kinase activity
Xcom_03195	COG4999	Histidine kinase
Xcom_03195	COG3850	Histidine kinase
Xcom_03200	COG0784	Response regulator, receiver
Xcom_03200	COG4191	Histidine kinase
Xcom_03220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Xcom_03225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Xcom_03235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Xcom_03240	COG0228	four-way junction DNA binding
Xcom_03245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Xcom_03250	COG0336	Belongs to the RNA methyltransferase TrmD family
Xcom_03255	COG0335	large ribosomal subunit rRNA binding
Xcom_03260	COG0534	Mate efflux family protein
Xcom_03295	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Xcom_03330	COG4221	oxidoreductase activity
Xcom_03345	COG0018	arginyl-trna synthetase
Xcom_03350	COG2003	Belongs to the UPF0758 family
Xcom_03355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Xcom_03360	COG0756	dUTP diphosphatase activity
Xcom_03380	COG0463	Glycosyl transferase, family 2
Xcom_03400	COG1475	DNA binding
Xcom_03405	COG1192	Involved in chromosome partitioning
Xcom_03415	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Xcom_03420	COG0708	Exodeoxyribonuclease III
Xcom_03425	COG2211	Major facilitator Superfamily
Xcom_03435	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Xcom_03440	COG0739	heme binding
Xcom_03445	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Xcom_03490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Xcom_03505	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
Xcom_03535	COG0109	protoheme IX farnesyltransferase activity
Xcom_03550	COG0358	DNA primase activity
Xcom_03555	COG1295	ribonuclease BN
Xcom_03565	COG1610	YqeY-like protein
Xcom_03570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Xcom_03575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Xcom_03580	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Xcom_03590	COG2133	pyrroloquinoline quinone binding
Xcom_03595	COG4682	membrane
Xcom_03610	COG0531	amino acid
Xcom_03620	COG4948	Mandelate Racemase Muconate Lactonizing
Xcom_03630	COG3023	N-Acetylmuramoyl-L-alanine amidase
Xcom_03635	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
Xcom_03685	COG5383	Protein conserved in bacteria
Xcom_03695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Xcom_03700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xcom_03705	COG1473	amidohydrolase
Xcom_03715	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Xcom_03715	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Xcom_03720	COG1652	LysM domain
Xcom_03740	COG0583	DNA-binding transcription factor activity
Xcom_03745	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
Xcom_03755	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Xcom_03760	COG3118	belongs to the thioredoxin family
Xcom_03765	COG0513	Belongs to the DEAD box helicase family
Xcom_03770	COG2884	Cell division ATP-binding protein ftsE
Xcom_03775	COG2177	Part of the ABC transporter FtsEX involved in
Xcom_03780	COG3437	response regulator, receiver
Xcom_03785	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Xcom_03790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Xcom_03795	COG2860	membrane
Xcom_03800	COG1252	NADH dehydrogenase
Xcom_03815	COG0625	glutathione transferase activity
Xcom_03820	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Xcom_03840	COG0534	Mate efflux family protein
Xcom_03845	COG0616	signal peptide processing
Xcom_03855	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_03870	COG0009	L-threonylcarbamoyladenylate synthase
Xcom_03875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Xcom_03875	COG1754	DNA topoisomerase type I activity
Xcom_03895	COG0758	DNA mediated transformation
Xcom_03900	COG1652	LysM domain
Xcom_03905	COG0242	peptide deformylase activity
Xcom_03910	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Xcom_03915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Xcom_03915	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Xcom_03965	COG1560	Kdo2-lipid A biosynthetic process
Xcom_03970	COG1490	D-aminoacyl-tRNA deacylase activity
Xcom_03975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Xcom_04000	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_04015	COG0024	Methionine aminopeptidase
Xcom_04025	COG0038	chloride channel
Xcom_04030	COG0659	secondary active sulfate transmembrane transporter activity
Xcom_04060	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Xcom_04065	COG0583	DNA-binding transcription factor activity
Xcom_04085	COG0251	oxidation-reduction process
Xcom_04160	COG1063	alcohol dehydrogenase
Xcom_04175	COG1132	(ABC) transporter
Xcom_04195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Xcom_04200	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_04215	COG1294	oxidase, subunit
Xcom_04220	COG1271	oxidase subunit
Xcom_04270	COG3546	catalase activity
Xcom_04275	COG3685	Protein conserved in bacteria
Xcom_04295	COG2972	Histidine kinase
Xcom_04310	COG0531	amino acid
Xcom_04325	COG3590	peptidase
Xcom_04340	COG0667	Aldo Keto reductase
Xcom_04350	COG0583	DNA-binding transcription factor activity
Xcom_04355	COG3384	dioxygenase
Xcom_04365	COG1573	uracil-dna glycosylase
Xcom_04370	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Xcom_04380	COG0025	NhaP-type Na H and K H
Xcom_04385	COG1131	(ABC) transporter
Xcom_04390	COG0842	Transport permease protein
Xcom_04450	COG1522	sequence-specific DNA binding
Xcom_04455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Xcom_04460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Xcom_04485	COG2205	protein histidine kinase activity
Xcom_04485	COG2202	Pas domain
Xcom_04510	COG1187	pseudouridine synthase activity
Xcom_04515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Xcom_04540	COG0784	Response regulator, receiver
Xcom_04540	COG2198	Histidine kinase
Xcom_04540	COG5002	protein histidine kinase activity
Xcom_04550	COG1666	GTP binding
Xcom_04555	COG0697	spore germination
Xcom_04560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Xcom_04565	COG2011	ABC-type metal ion transport system permease component
Xcom_04620	COG0508	dehydrogenase complex catalyzes the overall conversion of
Xcom_04630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Xcom_04660	COG0356	it plays a direct role in the translocation of protons across the membrane
Xcom_04670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Xcom_04675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Xcom_04680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Xcom_04685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Xcom_04690	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Xcom_04695	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Xcom_04710	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Xcom_04715	COG4191	Histidine kinase
Xcom_04720	COG2204	response regulator
Xcom_04730	COG0577	efflux transmembrane transporter activity
Xcom_04730	COG1136	(ABC) transporter
Xcom_04735	COG0577	efflux transmembrane transporter activity
Xcom_04740	COG1136	(ABC) transporter
Xcom_04745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xcom_04750	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Xcom_04785	COG2132	Multicopper oxidase
Xcom_04800	COG0339	signal peptide processing
Xcom_04815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Xcom_04825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Xcom_04840	COG1956	GAF domain-containing protein
Xcom_04845	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Xcom_04855	COG0720	synthase
Xcom_04860	COG0513	Belongs to the DEAD box helicase family
Xcom_04875	COG0625	glutathione transferase activity
Xcom_04905	COG0626	cystathionine gamma-synthase activity
Xcom_04915	COG0438	transferase activity, transferring glycosyl groups
Xcom_04935	COG0438	transferase activity, transferring glycosyl groups
Xcom_04940	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Xcom_04975	COG0463	Glycosyl transferase, family 2
Xcom_04990	COG2086	electron transfer activity
Xcom_05020	COG0662	Cupin 2, conserved barrel domain protein
Xcom_05020	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Xcom_05025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Xcom_05030	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Xcom_05060	COG3218	ABC-type transport auxiliary lipoprotein component
Xcom_05060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Xcom_05065	COG1127	ABC transporter
Xcom_05070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Xcom_05085	COG0442	prolyl-tRNA aminoacylation
Xcom_05095	COG1183	phosphatidylcholine synthase activity
Xcom_05115	COG2801	Transposase and inactivated derivatives
Xcom_05135	COG0525	valine-tRNA ligase activity
Xcom_05150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Xcom_05160	COG0795	lipopolysaccharide-transporting ATPase activity
Xcom_05175	COG4974	Belongs to the 'phage' integrase family
Xcom_05190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Xcom_05200	COG0047	phosphoribosylformylglycinamidine synthase activity
Xcom_05200	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Xcom_05210	COG5295	Hep Hag repeat protein
Xcom_05215	COG1404	Belongs to the peptidase S8 family
Xcom_05220	COG5295	Hep Hag repeat protein
Xcom_05225	COG1404	Belongs to the peptidase S8 family
Xcom_05230	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Xcom_05240	COG1459	type II secretion system
Xcom_05245	COG2165	general secretion pathway protein
Xcom_05250	COG4970	Tfp pilus assembly protein FimT
Xcom_05255	COG2165	general secretion pathway protein
Xcom_05260	COG4795	General secretion pathway protein
Xcom_05265	COG3156	type II secretion system protein K
Xcom_05270	COG3166	PFAM Fimbrial assembly family protein
Xcom_05285	COG1450	Type ii and iii secretion system protein
Xcom_05295	COG2188	Transcriptional regulator
Xcom_05345	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Xcom_05360	COG1215	transferase activity, transferring glycosyl groups
Xcom_05365	COG1215	transferase activity, transferring glycosyl groups
Xcom_05370	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Xcom_05375	COG0457	Tetratricopeptide repeat
Xcom_05405	COG0242	peptide deformylase activity
Xcom_05410	COG1307	EDD domain protein, DegV family
Xcom_05430	COG0402	S-adenosylhomocysteine deaminase activity
Xcom_05435	COG3964	amidohydrolase
Xcom_05450	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Xcom_05455	COG0726	polysaccharide deacetylase
Xcom_05470	COG0436	Aminotransferase
Xcom_05475	COG1162	GTPase activity
Xcom_05500	COG2211	Major facilitator Superfamily
Xcom_05505	COG1609	Transcriptional regulator
Xcom_05510	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_05515	COG2851	Citrate transporter
Xcom_05535	COG0642	Histidine kinase
Xcom_05540	COG1840	ABC-type Fe3 transport system, periplasmic component
Xcom_05550	COG2197	response regulator
Xcom_05565	COG0667	Aldo Keto reductase
Xcom_05570	COG0583	DNA-binding transcription factor activity
Xcom_05600	COG1301	dicarboxylic acid transport
Xcom_05605	COG0281	malic enzyme
Xcom_05605	COG0280	phosphate acetyltransferase
Xcom_05630	COG1560	Kdo2-lipid A biosynthetic process
Xcom_05640	COG1519	Transferase
Xcom_05645	COG1538	Outer membrane efflux protein
Xcom_05650	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Xcom_05660	COG3706	GGDEF domain
Xcom_05670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Xcom_05675	COG0066	3-isopropylmalate dehydratase activity
Xcom_05680	COG0473	3-isopropylmalate dehydrogenase activity
Xcom_05685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Xcom_05705	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Xcom_05710	COG0405	Gamma-glutamyltransferase
Xcom_05730	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Xcom_05735	COG3710	Transcriptional regulator
Xcom_05755	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Xcom_05765	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Xcom_05810	COG0563	adenylate kinase activity
Xcom_05815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Xcom_05825	COG3781	membrane
Xcom_05830	COG0671	phosphoesterase, PA-phosphatase related
Xcom_05840	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_05845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Xcom_05850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Xcom_05880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Xcom_05885	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
Xcom_05895	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Xcom_05910	COG0352	thiamine-phosphate diphosphorylase activity
Xcom_05915	COG1773	rubredoxin
Xcom_05920	COG2912	Transglutaminase-like superfamily
Xcom_05930	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Xcom_05940	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Xcom_05960	COG3079	Belongs to the UPF0149 family
Xcom_05965	COG0006	proline dipeptidase activity
Xcom_05975	COG0006	proline dipeptidase activity
Xcom_05990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Xcom_05995	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Xcom_06005	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Xcom_06010	COG1561	YicC-like family, N-terminal region
Xcom_06015	COG0194	GDP metabolic process
Xcom_06020	COG1758	RNA polymerase activity
Xcom_06025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Xcom_06035	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Xcom_06040	COG1957	nucleoside hydrolase
Xcom_06045	COG0254	rRNA binding
Xcom_06065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Xcom_06100	COG0714	Associated with various cellular activities
Xcom_06120	COG2304	oxidoreductase activity
Xcom_06135	COG1301	dicarboxylic acid transport
Xcom_06140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Xcom_06145	COG4773	Receptor
Xcom_06150	COG0739	heme binding
Xcom_06155	COG1376	ErfK ybiS ycfS ynhG family protein
Xcom_06190	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Xcom_06195	COG4149	molybdate abc transporter
Xcom_06200	COG0725	ABC transporter, periplasmic molybdate-binding protein
Xcom_06205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Xcom_06205	COG3453	Protein conserved in bacteria
Xcom_06215	COG3047	cAMP biosynthetic process
Xcom_06220	COG3047	cAMP biosynthetic process
Xcom_06230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Xcom_06255	COG0126	phosphoglycerate kinase activity
Xcom_06265	COG0469	pyruvate kinase activity
Xcom_06275	COG3588	fructose-bisphosphate aldolase
Xcom_06280	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Xcom_06295	COG1648	precorrin-2 dehydrogenase activity
Xcom_06295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Xcom_06340	COG0175	sulfate reduction
Xcom_06345	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Xcom_06350	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Xcom_06355	COG0175	sulfate reduction
Xcom_06360	COG0529	Catalyzes the synthesis of activated sulfate
Xcom_06360	COG2895	sulfate adenylyltransferase (ATP) activity
Xcom_06375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Xcom_06380	COG0308	aminopeptidase N
Xcom_06390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Xcom_06405	COG4948	Mandelate Racemase Muconate Lactonizing
Xcom_06410	COG3250	beta-galactosidase activity
Xcom_06420	COG1609	Transcriptional regulator
Xcom_06430	COG1970	mechanosensitive ion channel activity
Xcom_06455	COG3273	potassium ion transport
Xcom_06455	COG0471	metal ion transport
Xcom_06460	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Xcom_06470	COG2022	thiamine diphosphate biosynthetic process
Xcom_06515	COG0189	ligase activity
Xcom_06525	COG0745	RESPONSE REGULATOR receiver
Xcom_06550	COG0237	dephospho-CoA kinase activity
Xcom_06555	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Xcom_06560	COG1459	type II secretion system
Xcom_06590	COG0045	succinate-CoA ligase (ADP-forming) activity
Xcom_06595	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Xcom_06610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Xcom_06610	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Xcom_06620	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Xcom_06625	COG0564	pseudouridine synthase activity
Xcom_06640	COG3011	Protein conserved in bacteria
Xcom_06645	COG0840	transmembrane signaling receptor activity
Xcom_06665	COG3387	PFAM Glycoside hydrolase 15-related
Xcom_06670	COG1877	trehalose-phosphatase activity
Xcom_06725	COG0542	response to heat
Xcom_06730	COG4206	TonB-dependent receptor
Xcom_06750	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Xcom_06760	COG1492	cobalamin metabolic process
Xcom_06770	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Xcom_06790	COG0019	diaminopimelate decarboxylase activity
Xcom_06800	COG2814	Major facilitator Superfamily
Xcom_06805	COG4264	IucA IucC family
Xcom_06815	COG4772	TonB-dependent receptor
Xcom_06825	COG4651	solute:proton antiporter activity
Xcom_06825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Xcom_06885	COG0488	(ABC) transporter
Xcom_06905	COG0657	acetylesterase activity
Xcom_06905	COG2755	lipolytic protein G-D-S-L family
Xcom_06925	COG0477	Major facilitator Superfamily
Xcom_06940	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Xcom_06955	COG0217	transcriptional regulatory protein
Xcom_06960	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Xcom_06965	COG0632	four-way junction helicase activity
Xcom_06970	COG3158	transport of potassium into the cell
Xcom_06980	COG2255	four-way junction helicase activity
Xcom_06985	COG0824	Thioesterase
Xcom_06995	COG0848	biopolymer transport protein
Xcom_07005	COG0823	Involved in the tonB-independent uptake of proteins
Xcom_07010	COG2885	chlorophyll binding
Xcom_07020	COG0602	queuosine metabolic process
Xcom_07035	COG3920	Histidine kinase
Xcom_07055	COG0840	transmembrane signaling receptor activity
Xcom_07070	COG1187	pseudouridine synthase activity
Xcom_07105	COG0514	ATP-dependent DNA helicase (RecQ)
Xcom_07110	COG0783	Belongs to the Dps family
Xcom_07115	COG1643	Atp-dependent helicase
Xcom_07125	COG0837	glucose binding
Xcom_07145	COG0535	radical SAM domain protein
Xcom_07150	COG0535	radical SAM domain protein
Xcom_07155	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
Xcom_07160	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Xcom_07170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Xcom_07185	COG1215	transferase activity, transferring glycosyl groups
Xcom_07190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Xcom_07200	COG1199	ATP-dependent helicase activity
Xcom_07205	COG1214	PFAM Peptidase M22, glycoprotease
Xcom_07225	COG0189	ligase activity
Xcom_07245	COG0840	transmembrane signaling receptor activity
Xcom_07280	COG1595	DNA-templated transcription, initiation
Xcom_07285	COG2304	oxidoreductase activity
Xcom_07290	COG1446	asparaginase
Xcom_07295	COG3142	Participates in the control of copper homeostasis
Xcom_07335	COG3537	Alpha-1,2-mannosidase
Xcom_07345	COG1472	Belongs to the glycosyl hydrolase 3 family
Xcom_07360	COG3858	chitin binding
Xcom_07360	COG1388	LysM domain
Xcom_07375	COG0837	glucose binding
Xcom_07380	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Xcom_07390	COG0494	nUDIX hydrolase
Xcom_07400	COG3956	TIGRFAM MazG family protein
Xcom_07405	COG1742	UPF0060 membrane protein
Xcom_07420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Xcom_07425	COG0509	glycine decarboxylation via glycine cleavage system
Xcom_07450	COG1960	acyl-CoA dehydrogenase activity
Xcom_07455	COG2267	carboxylic ester hydrolase activity
Xcom_07460	COG1309	transcriptional regulator
Xcom_07465	COG4771	TonB-dependent receptor
Xcom_07475	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Xcom_07480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Xcom_07485	COG0463	Glycosyl transferase, family 2
Xcom_07490	COG0516	GMP reductase activity
Xcom_07490	COG0517	IMP dehydrogenase activity
Xcom_07495	COG2982	Protein involved in outer membrane biogenesis
Xcom_07500	COG1272	protein, Hemolysin III
Xcom_07505	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Xcom_07510	COG0739	heme binding
Xcom_07520	COG0626	cystathionine gamma-synthase activity
Xcom_07525	COG0527	aspartate kinase activity
Xcom_07525	COG0460	homoserine dehydrogenase
Xcom_07540	COG1760	l-serine dehydratase
Xcom_07560	COG2353	YceI-like domain
Xcom_07565	COG2198	Histidine kinase
Xcom_07565	COG0784	Response regulator, receiver
Xcom_07565	COG2205	protein histidine kinase activity
Xcom_07585	COG2814	Major facilitator Superfamily
Xcom_07590	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Xcom_07600	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Xcom_07605	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Xcom_07610	COG0259	pyridoxamine-phosphate oxidase activity
Xcom_07620	COG1842	Phage shock protein A
Xcom_07645	COG0754	glutathionylspermidine amidase activity
Xcom_07650	COG2814	Major facilitator Superfamily
Xcom_07735	COG0531	amino acid
Xcom_07740	COG2197	response regulator
Xcom_07775	COG1113	amino acid transport
Xcom_07785	COG1271	oxidase subunit
Xcom_07790	COG1294	oxidase, subunit
Xcom_07800	COG2239	Acts as a magnesium transporter
Xcom_07810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Xcom_07815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Xcom_07825	COG1660	Displays ATPase and GTPase activities
Xcom_07830	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Xcom_07835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Xcom_07850	COG1137	ATPase activity
Xcom_07855	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Xcom_07865	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Xcom_07875	COG0271	Belongs to the BolA IbaG family
Xcom_07880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Xcom_07900	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Xcom_07910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Xcom_07920	COG0628	permease
Xcom_07930	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Xcom_07950	COG1555	photosystem II stabilization
Xcom_07965	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Xcom_07970	COG1477	protein flavinylation
Xcom_07995	COG3128	pkhd-type hydroxylase
Xcom_08000	COG4774	siderophore transport
Xcom_08010	COG0456	acetyltransferase
Xcom_08015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Xcom_08020	COG0719	Fe-S assembly protein
Xcom_08025	COG0396	ATPase activity
Xcom_08030	COG0719	Fe-S assembly protein
Xcom_08035	COG1959	2 iron, 2 sulfur cluster binding
Xcom_08045	COG0693	protein deglycase activity
Xcom_08065	COG0739	heme binding
Xcom_08080	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Xcom_08110	COG0519	Catalyzes the synthesis of GMP from XMP
Xcom_08120	COG1678	Uncharacterized ACR, COG1678
Xcom_08125	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Xcom_08130	COG0540	Belongs to the ATCase OTCase family
Xcom_08135	COG1764	response to oxidative stress
Xcom_08145	COG0384	phenazine biosynthesis protein PhzF
Xcom_08150	COG0384	phenazine biosynthesis protein PhzF
Xcom_08155	COG0527	aspartate kinase activity
Xcom_08170	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Xcom_08185	COG0142	geranyltranstransferase activity
Xcom_08190	COG0629	single-stranded DNA binding
Xcom_08195	COG4251	negative regulation of phosphorylation
Xcom_08195	COG2203	Gaf domain
Xcom_08195	COG3706	GGDEF domain
Xcom_08195	COG5001	Diguanylate cyclase
Xcom_08200	COG3321	synthase
Xcom_08200	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_08200	COG0604	alcohol dehydrogenase
Xcom_08205	COG2080	2 iron, 2 sulfur cluster binding
Xcom_08210	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Xcom_08215	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Xcom_08220	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Xcom_08265	COG2879	small protein
Xcom_08275	COG1741	Belongs to the pirin family
Xcom_08290	COG1741	Belongs to the pirin family
Xcom_08305	COG1515	deoxyribonuclease V activity
Xcom_08310	COG0588	phosphoglycerate mutase activity
Xcom_08320	COG3590	peptidase
Xcom_08325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Xcom_08330	COG2201	protein-glutamate methylesterase activity
Xcom_08335	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Xcom_08340	COG2202	Pas domain
Xcom_08340	COG2199	diguanylate cyclase activity
Xcom_08340	COG2200	EAL domain
Xcom_08345	COG0835	chemotaxis
Xcom_08350	COG0840	transmembrane signaling receptor activity
Xcom_08355	COG0643	Histidine kinase
Xcom_08355	COG2198	Histidine kinase
Xcom_08365	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Xcom_08380	COG0745	RESPONSE REGULATOR receiver
Xcom_08385	COG2205	protein histidine kinase activity
Xcom_08395	COG4452	Inner membrane protein CreD
Xcom_08420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Xcom_08425	COG0735	belongs to the Fur family
Xcom_08440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Xcom_08445	COG1538	Outer membrane efflux protein
Xcom_08450	COG1309	transcriptional regulator
Xcom_08465	COG2207	Transcriptional regulator
Xcom_08475	COG0583	DNA-binding transcription factor activity
Xcom_08485	COG0667	Aldo Keto reductase
Xcom_08605	COG5002	protein histidine kinase activity
Xcom_08605	COG5001	Diguanylate cyclase
Xcom_08610	COG1187	pseudouridine synthase activity
Xcom_08615	COG3706	GGDEF domain
Xcom_08635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Xcom_08640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Xcom_08645	COG0475	glutathione-regulated potassium exporter activity
Xcom_08650	COG5000	phosphorelay sensor kinase activity
Xcom_08650	COG5002	protein histidine kinase activity
Xcom_08655	COG0745	RESPONSE REGULATOR receiver
Xcom_08660	COG1538	Outer membrane efflux protein
Xcom_08685	COG1132	(ABC) transporter
Xcom_08730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Xcom_08735	COG2155	Conserved Protein
Xcom_08770	COG3118	belongs to the thioredoxin family
Xcom_08780	COG0495	leucyl-tRNA aminoacylation
Xcom_08810	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Xcom_08825	COG2968	Membrane
Xcom_08830	COG0424	maF-like protein
Xcom_08835	COG1530	ribonuclease E activity
Xcom_08840	COG3164	Protein of unknown function
Xcom_08850	COG0312	modulator of DNA gyrase
Xcom_08855	COG3028	Belongs to the UPF0307 family
Xcom_08860	COG0312	modulator of DNA gyrase
Xcom_08870	COG4104	PAAR repeat-containing protein
Xcom_08875	COG0142	geranyltranstransferase activity
Xcom_08880	COG1722	exodeoxyribonuclease VII activity
Xcom_08885	COG0037	tRNA processing
Xcom_08895	COG1785	Belongs to the alkaline phosphatase family
Xcom_08900	COG1301	dicarboxylic acid transport
Xcom_08915	COG0791	NLP P60 protein
Xcom_08920	COG0791	NLP P60 protein
Xcom_08925	COG1047	Peptidyl-prolyl cis-trans
Xcom_08930	COG2311	Membrane
Xcom_08935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Xcom_08940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Xcom_08960	COG3590	peptidase
Xcom_08970	COG3590	peptidase
Xcom_08990	COG0489	protein tyrosine kinase activity
Xcom_09000	COG0717	Belongs to the dCTP deaminase family
Xcom_09025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Xcom_09030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Xcom_09050	COG0494	nUDIX hydrolase
Xcom_09055	COG0433	COG0433 Predicted ATPase
Xcom_09065	COG0688	phosphatidylethanolamine metabolic process
Xcom_09075	COG2890	protein-(glutamine-N5) methyltransferase activity
Xcom_09080	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Xcom_09085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Xcom_09090	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Xcom_09105	COG0101	tRNA pseudouridine synthase activity
Xcom_09110	COG0135	phosphoribosylanthranilate isomerase activity
Xcom_09120	COG0133	tryptophan synthase activity
Xcom_09130	COG0159	tryptophan synthase activity
Xcom_09135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Xcom_09140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Xcom_09185	COG4221	oxidoreductase activity
Xcom_09190	COG0149	triose-phosphate isomerase activity
Xcom_09205	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Xcom_09210	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Xcom_09215	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Xcom_09220	COG0649	NAD binding
Xcom_09225	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Xcom_09230	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Xcom_09235	COG1034	ATP synthesis coupled electron transport
Xcom_09240	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Xcom_09245	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Xcom_09255	COG0713	ATP synthesis coupled electron transport
Xcom_09270	COG1007	ATP synthesis coupled electron transport
Xcom_09280	COG0779	Required for maturation of 30S ribosomal subunits
Xcom_09285	COG0195	Participates in both transcription termination and antitermination
Xcom_09290	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Xcom_09295	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Xcom_09300	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Xcom_09305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Xcom_09310	COG1185	polyribonucleotide nucleotidyltransferase activity
Xcom_09340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Xcom_09345	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Xcom_09355	COG2095	MarC family integral membrane protein
Xcom_09370	COG1611	Belongs to the LOG family
Xcom_09415	COG0556	nucleotide-excision repair
Xcom_09435	COG3505	Type IV secretory pathway VirD4
Xcom_09455	COG1082	Xylose isomerase domain protein TIM barrel
Xcom_09480	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Xcom_09485	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Xcom_09490	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Xcom_09495	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Xcom_09500	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Xcom_09505	COG0072	phenylalanine-tRNA ligase activity
Xcom_09505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Xcom_09510	COG0776	regulation of translation
Xcom_09555	COG0438	transferase activity, transferring glycosyl groups
Xcom_09560	COG0438	transferase activity, transferring glycosyl groups
Xcom_09595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Xcom_09600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Xcom_09605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Xcom_09625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Xcom_09635	COG1960	acyl-CoA dehydrogenase activity
Xcom_09645	COG3040	lipid binding
Xcom_09660	COG0322	excinuclease ABC activity
Xcom_09675	COG4191	Histidine kinase
Xcom_09675	COG0784	Response regulator, receiver
Xcom_09685	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Xcom_09690	COG1194	a g-specific adenine glycosylase
Xcom_09700	COG0552	protein localization to endoplasmic reticulum
Xcom_09710	COG3938	Belongs to the proline racemase family
Xcom_09715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Xcom_09730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Xcom_09740	COG0006	proline dipeptidase activity
Xcom_09755	COG0531	amino acid
Xcom_09835	COG0326	Molecular chaperone. Has ATPase activity
Xcom_09840	COG0742	ribosomal rna small subunit methyltransferase
Xcom_09845	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Xcom_09860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Xcom_09865	COG0405	Gamma-glutamyltransferase
Xcom_09870	COG3291	Pkd domain containing protein
Xcom_09875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Xcom_09915	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Xcom_09920	COG0343	queuine tRNA-ribosyltransferase activity
Xcom_09925	COG1862	Preprotein translocase
Xcom_09935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Xcom_09975	COG1501	Belongs to the glycosyl hydrolase 31 family
Xcom_09985	COG1070	Carbohydrate kinase
Xcom_09990	COG2115	Belongs to the xylose isomerase family
Xcom_09995	COG0477	Major facilitator Superfamily
Xcom_10015	COG0860	N-Acetylmuramoyl-L-alanine amidase
Xcom_10020	COG1469	GTP cyclohydrolase I activity
Xcom_10040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Xcom_10045	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Xcom_10050	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Xcom_10055	COG0166	Belongs to the GPI family
Xcom_10080	COG1472	Belongs to the glycosyl hydrolase 3 family
Xcom_10095	COG4251	negative regulation of phosphorylation
Xcom_10095	COG3706	GGDEF domain
Xcom_10095	COG5001	Diguanylate cyclase
Xcom_10095	COG2203	Gaf domain
Xcom_10105	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Xcom_10110	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Xcom_10120	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Xcom_10125	COG0671	phosphoesterase, PA-phosphatase related
Xcom_10135	COG1794	racemase activity, acting on amino acids and derivatives
Xcom_10140	COG0697	spore germination
Xcom_10145	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Xcom_10150	COG0167	dihydroorotate dehydrogenase activity
Xcom_10170	COG1012	belongs to the aldehyde dehydrogenase family
Xcom_10185	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Xcom_10205	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Xcom_10215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Xcom_10220	COG0124	histidyl-tRNA synthetase
Xcom_10230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Xcom_10235	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Xcom_10240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Xcom_10245	COG0131	Imidazoleglycerol-phosphate dehydratase
Xcom_10245	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Xcom_10250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Xcom_10255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Xcom_10260	COG0107	imidazoleglycerol-phosphate synthase activity
Xcom_10265	COG0140	phosphoribosyl-ATP diphosphatase activity
Xcom_10265	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Xcom_10280	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Xcom_10285	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Xcom_10290	COG0235	Class ii aldolase
Xcom_10295	COG0531	amino acid
Xcom_10300	COG0531	amino acid
Xcom_10310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Xcom_10315	COG0277	FAD linked oxidase domain protein
Xcom_10335	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Xcom_10380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Xcom_10385	COG2258	MOSC domain
Xcom_10395	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Xcom_10400	COG0505	Belongs to the CarA family
Xcom_10410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Xcom_10415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Xcom_10425	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Xcom_10435	COG3279	Response regulator of the LytR AlgR family
Xcom_10445	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Xcom_10460	COG0784	Response regulator, receiver
Xcom_10460	COG2198	Histidine kinase
Xcom_10460	COG2205	protein histidine kinase activity
Xcom_10465	COG1024	Enoyl-CoA hydratase
Xcom_10470	COG0318	PFAM AMP-dependent synthetase and ligase
Xcom_10505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Xcom_10515	COG2201	protein-glutamate methylesterase activity
Xcom_10520	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Xcom_10530	COG0840	transmembrane signaling receptor activity
Xcom_10540	COG0835	chemotaxis
Xcom_10560	COG0840	transmembrane signaling receptor activity
Xcom_10565	COG0840	transmembrane signaling receptor activity
Xcom_10575	COG0840	transmembrane signaling receptor activity
Xcom_10585	COG0840	transmembrane signaling receptor activity
Xcom_10590	COG0840	transmembrane signaling receptor activity
Xcom_10595	COG0840	transmembrane signaling receptor activity
Xcom_10600	COG0840	transmembrane signaling receptor activity
Xcom_10610	COG0840	transmembrane signaling receptor activity
Xcom_10615	COG0840	transmembrane signaling receptor activity
Xcom_10640	COG0745	RESPONSE REGULATOR receiver
Xcom_10655	COG1192	Involved in chromosome partitioning
Xcom_10660	COG1360	Flagellar Motor Protein
Xcom_10665	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Xcom_10685	COG2198	Histidine kinase
Xcom_10685	COG0643	Histidine kinase
Xcom_10705	COG0455	bacterial-type flagellum organization
Xcom_10715	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Xcom_10730	COG3300	MHYT domain
Xcom_10730	COG5001	Diguanylate cyclase
Xcom_10740	COG3300	MHYT domain
Xcom_10740	COG5001	Diguanylate cyclase
Xcom_10745	COG1684	flagellar biosynthetic protein fliR
Xcom_10750	COG1987	bacterial-type flagellum assembly
Xcom_10795	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_10800	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_10805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Xcom_10820	COG2204	response regulator
Xcom_10825	COG2201	protein-glutamate methylesterase activity
Xcom_10855	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Xcom_10860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Xcom_10865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Xcom_10875	COG1705	Flagellar rod assembly protein muramidase FlgJ
Xcom_10875	COG3951	Flagellar rod assembly protein muramidase FlgJ
Xcom_10880	COG1706	bacterial-type flagellum-dependent cell motility
Xcom_10885	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Xcom_10890	COG4786	Flagellar basal body rod
Xcom_10900	COG4787	bacterial-type flagellum-dependent cell motility
Xcom_10905	COG1749	Flagellar hook protein flgE
Xcom_10910	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Xcom_10915	COG1558	bacterial-type flagellum-dependent cell motility
Xcom_10925	COG0784	Response regulator, receiver
Xcom_10925	COG0835	chemotaxis
Xcom_10945	COG5002	protein histidine kinase activity
Xcom_10980	COG2915	High frequency lysogenization protein hflD homolog
Xcom_10985	COG0482	sulfurtransferase activity
Xcom_10995	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Xcom_11000	COG0542	response to heat
Xcom_11005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Xcom_11010	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Xcom_11025	COG0492	ferredoxin-NADP+ reductase activity
Xcom_11030	COG1674	ftsk spoiiie
Xcom_11040	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Xcom_11055	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Xcom_11060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Xcom_11065	COG0183	Belongs to the thiolase family
Xcom_11070	COG1250	3-hydroxyacyl-CoA dehydrogenase
Xcom_11070	COG1024	Enoyl-CoA hydratase
Xcom_11080	COG0105	UTP biosynthetic process
Xcom_11085	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Xcom_11095	COG1426	Protein conserved in bacteria
Xcom_11105	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Xcom_11110	COG1160	GTP binding
Xcom_11115	COG0303	'Molybdopterin
Xcom_11120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Xcom_11160	COG0708	Exodeoxyribonuclease III
Xcom_11170	COG0303	'Molybdopterin
Xcom_11175	COG0746	molybdenum cofactor guanylyltransferase activity
Xcom_11200	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Xcom_11200	COG1648	precorrin-2 dehydrogenase activity
Xcom_11210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Xcom_11215	COG2223	nitrite transmembrane transporter activity
Xcom_11220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Xcom_11230	COG0243	molybdopterin cofactor binding
Xcom_11250	COG3685	Protein conserved in bacteria
Xcom_11265	COG5001	Diguanylate cyclase
Xcom_11275	COG4566	intracellular signal transduction
Xcom_11295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xcom_11320	COG3279	Response regulator of the LytR AlgR family
Xcom_11460	COG0800	Aldolase
Xcom_11465	COG0129	dihydroxy-acid dehydratase activity
Xcom_11470	COG0363	glucosamine-6-phosphate deaminase activity
Xcom_11475	COG0837	glucose binding
Xcom_11480	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Xcom_11490	COG0354	folic acid binding
Xcom_11505	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
Xcom_11520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Xcom_11525	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Xcom_11535	COG4591	ABC-type transport system involved in lipoprotein release permease component
Xcom_11540	COG1136	(ABC) transporter
Xcom_11555	COG0811	peptide transport
Xcom_11565	COG1132	(ABC) transporter
Xcom_11570	COG1663	tetraacyldisaccharide 4'-kinase activity
Xcom_11575	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Xcom_11580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Xcom_11590	COG0322	excinuclease ABC activity
Xcom_11595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Xcom_11620	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Xcom_11650	COG1530	ribonuclease E activity
Xcom_11660	COG3064	Membrane
Xcom_11665	COG0428	transporter
Xcom_11675	COG2154	pterin-4-alpha-carbinolamine dehydratase
Xcom_11680	COG0316	Belongs to the HesB IscA family
Xcom_11680	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Xcom_11695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xcom_11700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Xcom_11705	COG1309	transcriptional regulator
Xcom_11715	COG0596	Alpha beta hydrolase
Xcom_11750	COG0363	glucosamine-6-phosphate deaminase activity
Xcom_11765	COG2226	methyltransferase
Xcom_11765	COG1073	alpha beta
Xcom_11775	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_11805	COG0640	Transcriptional regulator
Xcom_11900	COG2205	protein histidine kinase activity
Xcom_11900	COG0784	Response regulator, receiver
Xcom_11905	COG2183	response to ionizing radiation
Xcom_11915	COG0723	plastoquinol--plastocyanin reductase activity
Xcom_11915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Xcom_11930	COG3243	poly(R)-hydroxyalkanoic acid synthase
Xcom_11940	COG1183	phosphatidylcholine synthase activity
Xcom_11945	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_11960	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Xcom_11970	COG0668	transmembrane transport
Xcom_11975	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Xcom_11980	COG0590	tRNA wobble adenosine to inosine editing
Xcom_11985	COG1321	iron dependent repressor
Xcom_11990	COG1914	H( )-stimulated, divalent metal cation uptake system
Xcom_12010	COG2814	Major facilitator Superfamily
Xcom_12025	COG1335	isochorismatase
Xcom_12035	COG4585	Histidine kinase
Xcom_12040	COG2197	response regulator
Xcom_12060	COG0583	DNA-binding transcription factor activity
Xcom_12080	COG0633	Ferredoxin
Xcom_12090	COG0583	DNA-binding transcription factor activity
Xcom_12095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Xcom_12100	COG3002	Belongs to the UPF0753 family
Xcom_12110	COG0583	DNA-binding transcription factor activity
Xcom_12130	COG4197	protein conserved in bacteria, prophage-related
Xcom_12155	COG2951	lytic endotransglycosylase activity
Xcom_12170	COG2197	response regulator
Xcom_12175	COG4585	Histidine kinase
Xcom_12205	COG1858	cytochrome C peroxidase
Xcom_12235	COG0515	serine threonine protein kinase
Xcom_12240	COG0631	protein serine/threonine phosphatase activity
Xcom_12275	COG3501	Rhs element vgr protein
Xcom_12290	COG0582	viral genome integration into host DNA
Xcom_12295	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Xcom_12295	COG0519	Catalyzes the synthesis of GMP from XMP
Xcom_12305	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Xcom_12315	COG0475	glutathione-regulated potassium exporter activity
Xcom_12315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Xcom_12325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Xcom_12335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Xcom_12340	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Xcom_12350	COG0776	regulation of translation
Xcom_12355	COG0539	negative regulation of cytoplasmic translation
Xcom_12360	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Xcom_12365	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Xcom_12375	COG2957	Belongs to the agmatine deiminase family
Xcom_12380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Xcom_12405	COG0395	ABC-type sugar transport system, permease component
Xcom_12410	COG1175	transmembrane transport
Xcom_12440	COG2350	Protein conserved in bacteria
Xcom_12445	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Xcom_12450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Xcom_12455	COG1187	pseudouridine synthase activity
Xcom_12475	COG0436	Aminotransferase
Xcom_12480	COG4133	protoheme IX ABC transporter activity
Xcom_12500	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Xcom_12505	COG1138	Cytochrome C-type biogenesis protein
Xcom_12525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Xcom_12530	COG1278	Cold shock
Xcom_12535	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Xcom_12540	COG4988	ABC transporter
Xcom_12550	COG1294	oxidase, subunit
Xcom_12580	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Xcom_12585	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Xcom_12595	COG0165	Argininosuccinate lyase
Xcom_12600	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Xcom_12610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Xcom_12625	COG0137	argininosuccinate synthase activity
Xcom_12630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Xcom_12640	COG0215	cysteine-tRNA ligase activity
Xcom_12645	COG2166	iron-sulfur cluster assembly
Xcom_12655	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Xcom_12660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Xcom_12665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Xcom_12695	COG4302	ethanolamine ammonia-lyase activity
Xcom_12720	COG4677	pectinesterase activity
Xcom_12735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Xcom_12740	COG0402	S-adenosylhomocysteine deaminase activity
Xcom_12750	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Xcom_12755	COG1509	lysine 2,3-aminomutase activity
Xcom_12760	COG3300	MHYT domain
Xcom_12760	COG5001	Diguanylate cyclase
Xcom_12775	COG0483	inositol monophosphate 1-phosphatase activity
Xcom_12800	COG0513	Belongs to the DEAD box helicase family
Xcom_12805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Xcom_12810	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Xcom_12820	COG0625	glutathione transferase activity
Xcom_12830	COG4681	YaeQ
Xcom_12835	COG2081	HI0933 family
Xcom_12845	COG0501	Belongs to the peptidase M48B family
Xcom_12850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Xcom_12855	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_12880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Xcom_12885	COG0860	N-Acetylmuramoyl-L-alanine amidase
Xcom_12890	COG0802	atpase or kinase
Xcom_12895	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Xcom_12895	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Xcom_12900	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Xcom_12905	COG1570	exodeoxyribonuclease VII activity
Xcom_12920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Xcom_12970	COG0835	chemotaxis
Xcom_12975	COG0840	transmembrane signaling receptor activity
Xcom_12980	COG2094	Belongs to the DNA glycosylase MPG family
Xcom_12985	COG1201	RNA secondary structure unwinding
Xcom_13005	COG2969	positive regulation of protein catabolic process
Xcom_13010	COG0625	glutathione transferase activity
Xcom_13015	COG2857	Cytochrome c1
Xcom_13020	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Xcom_13025	COG0723	plastoquinol--plastocyanin reductase activity
Xcom_13035	COG0741	lytic transglycosylase activity
Xcom_13050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Xcom_13055	COG1702	phosphate starvation-inducible protein PhoH
Xcom_13065	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Xcom_13075	COG4535	Mg2 and Co2 transporter CorC
Xcom_13090	COG1012	belongs to the aldehyde dehydrogenase family
Xcom_13095	COG1177	transmembrane transport
Xcom_13100	COG1176	ABC-type spermidine putrescine transport system, permease component I
Xcom_13110	COG3842	ATPase activity
Xcom_13130	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Xcom_13145	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Xcom_13150	COG0174	glutamine synthetase
Xcom_13155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Xcom_13160	COG0745	RESPONSE REGULATOR receiver
Xcom_13160	COG3706	GGDEF domain
Xcom_13165	COG2703	oxygen carrier activity
Xcom_13170	COG0477	Major facilitator Superfamily
Xcom_13180	COG0243	molybdopterin cofactor binding
Xcom_13185	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Xcom_13210	COG2733	membrane
Xcom_13215	COG0784	Response regulator, receiver
Xcom_13215	COG5002	protein histidine kinase activity
Xcom_13215	COG2205	protein histidine kinase activity
Xcom_13225	COG0477	Major facilitator Superfamily
Xcom_13230	COG2902	Dehydrogenase
Xcom_13240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xcom_13245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Xcom_13250	COG1609	Transcriptional regulator
Xcom_13255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Xcom_13255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Xcom_13260	COG1105	Belongs to the carbohydrate kinase PfkB family
Xcom_13265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Xcom_13265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Xcom_13305	COG0800	Aldolase
Xcom_13310	COG4948	Mandelate Racemase Muconate Lactonizing
Xcom_13320	COG3734	2-keto-3-deoxy-galactonokinase
Xcom_13325	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Xcom_13335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Xcom_13350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Xcom_13355	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Xcom_13370	COG0351	phosphomethylpyrimidine kinase
Xcom_13395	COG0583	DNA-binding transcription factor activity
Xcom_13400	COG1741	Belongs to the pirin family
Xcom_13420	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Xcom_13425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Xcom_13430	COG2137	regulation of response to DNA damage stimulus
Xcom_13440	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Xcom_13445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Xcom_13455	COG1546	Belongs to the CinA family
Xcom_13460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Xcom_13465	COG1923	regulation of RNA biosynthetic process
Xcom_13470	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Xcom_13475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Xcom_13480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Xcom_13485	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Xcom_13490	COG1534	Rna-binding protein
Xcom_13505	COG1238	metal cluster binding
Xcom_13510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Xcom_13515	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Xcom_13520	COG2840	Smr protein MutS2
Xcom_13525	COG0585	pseudouridine synthase activity
Xcom_13530	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Xcom_13535	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Xcom_13540	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Xcom_13545	COG0148	phosphopyruvate hydratase activity
Xcom_13555	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Xcom_13560	COG0504	CTP synthase activity
Xcom_13585	COG0306	phosphate transporter
Xcom_13600	COG1253	flavin adenine dinucleotide binding
Xcom_13615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Xcom_13620	COG2271	Major facilitator Superfamily
Xcom_13625	COG1132	(ABC) transporter
Xcom_13630	COG1136	(ABC) transporter
Xcom_13650	COG0438	transferase activity, transferring glycosyl groups
Xcom_13660	COG2264	protein methyltransferase activity
Xcom_13690	COG2244	polysaccharide biosynthetic process
Xcom_13745	COG1595	DNA-templated transcription, initiation
Xcom_13760	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Xcom_13770	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Xcom_13780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Xcom_13795	COG0784	Response regulator, receiver
Xcom_13795	COG4191	Histidine kinase
Xcom_13800	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Xcom_13810	COG2205	protein histidine kinase activity
Xcom_13810	COG0784	Response regulator, receiver
Xcom_13810	COG5002	protein histidine kinase activity
Xcom_13830	COG0840	transmembrane signaling receptor activity
Xcom_13885	COG0583	DNA-binding transcription factor activity
Xcom_13890	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Xcom_13895	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Xcom_13910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Xcom_13915	COG0077	Prephenate dehydratase
Xcom_13915	COG1605	Chorismate mutase
Xcom_13920	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Xcom_13925	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Xcom_13930	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Xcom_13970	COG1228	amidohydrolase
Xcom_13975	COG2986	histidine ammonia-lyase
Xcom_13985	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Xcom_13995	COG4993	Dehydrogenase
Xcom_14005	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Xcom_14020	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Xcom_14025	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Xcom_14030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Xcom_14040	COG3115	cell septum assembly
Xcom_14050	COG0359	binds to the 23S rRNA
Xcom_14055	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Xcom_14060	COG0360	Binds together with S18 to 16S ribosomal RNA
Xcom_14065	COG0316	Belongs to the HesB IscA family
Xcom_14075	COG0017	Asparaginyl-tRNA synthetase
Xcom_14145	COG0288	reversible hydration of carbon dioxide
Xcom_14150	COG0662	Cupin 2, conserved barrel domain protein
Xcom_14160	COG3844	kynureninase activity
Xcom_14165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Xcom_14175	COG2925	Exonuclease
Xcom_14195	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Xcom_14200	COG0116	Belongs to the methyltransferase superfamily
Xcom_14200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Xcom_14245	COG0494	nUDIX hydrolase
Xcom_14255	COG1024	Enoyl-CoA hydratase
Xcom_14265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Xcom_14270	COG0659	secondary active sulfate transmembrane transporter activity
Xcom_14295	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Xcom_14300	COG0573	inorganic phosphate transmembrane transporter activity
Xcom_14305	COG0581	inorganic phosphate transmembrane transporter activity
Xcom_14310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Xcom_14315	COG0704	Plays a role in the regulation of phosphate uptake
Xcom_14325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Xcom_14335	COG3706	GGDEF domain
Xcom_14345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Xcom_14360	COG0557	exoribonuclease II activity
Xcom_14385	COG1960	acyl-CoA dehydrogenase activity
Xcom_14395	COG1410	methionine synthase
Xcom_14395	COG0646	methionine synthase
Xcom_14400	COG1410	methionine synthase
Xcom_14400	COG0646	methionine synthase
Xcom_14410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Xcom_14435	COG2900	Belongs to the SlyX family
Xcom_14450	COG0386	Belongs to the glutathione peroxidase family
Xcom_14460	COG1725	Transcriptional regulator
Xcom_14465	COG1131	(ABC) transporter
Xcom_14500	COG1253	flavin adenine dinucleotide binding
Xcom_14520	COG2850	peptidyl-arginine hydroxylation
Xcom_14555	COG1132	(ABC) transporter
Xcom_14565	COG0583	DNA-binding transcription factor activity
Xcom_14595	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
Xcom_14605	COG0484	heat shock protein binding
Xcom_14610	COG0443	Heat shock 70 kDa protein
Xcom_14615	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Xcom_14620	COG1420	regulation of RNA biosynthetic process
Xcom_14625	COG0497	DNA recombination
Xcom_14635	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Xcom_14650	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Xcom_14680	COG3706	GGDEF domain
Xcom_14690	COG3706	GGDEF domain
Xcom_14725	COG0583	DNA-binding transcription factor activity
Xcom_14740	COG0415	Belongs to the DNA photolyase family
Xcom_14745	COG0305	Participates in initiation and elongation during chromosome replication
Xcom_14755	COG0367	asparagine synthase
Xcom_14775	COG1960	acyl-CoA dehydrogenase activity
Xcom_14790	COG0084	hydrolase, TatD family'
Xcom_14855	COG0386	Belongs to the glutathione peroxidase family
Xcom_14860	COG0339	signal peptide processing
Xcom_14925	COG2814	Major facilitator Superfamily
Xcom_14930	COG1566	PFAM secretion protein HlyD family protein
Xcom_14955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Xcom_14970	COG4774	siderophore transport
Xcom_14980	COG0367	asparagine synthase
Xcom_14985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Xcom_14990	COG1393	Belongs to the ArsC family
Xcom_15000	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Xcom_15005	COG0024	Methionine aminopeptidase
Xcom_15040	COG0052	Belongs to the universal ribosomal protein uS2 family
Xcom_15045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Xcom_15050	COG3706	GGDEF domain
Xcom_15050	COG0745	RESPONSE REGULATOR receiver
Xcom_15055	COG0528	UMP kinase activity
Xcom_15060	COG0233	cytoplasmic translational termination
Xcom_15065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Xcom_15070	COG0575	Belongs to the CDS family
Xcom_15075	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Xcom_15080	COG0750	zinc metalloprotease
Xcom_15095	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Xcom_15100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Xcom_15105	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Xcom_15110	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Xcom_15125	COG0825	malonyl-CoA metabolic process
Xcom_15160	COG1695	Transcriptional regulator
Xcom_15180	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Xcom_15190	COG2040	homocysteine
Xcom_15220	COG0346	lactoylglutathione lyase activity
Xcom_15240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Xcom_15240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Xcom_15250	COG2878	Part of a membrane complex involved in electron transport
Xcom_15265	COG1595	DNA-templated transcription, initiation
Xcom_15305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Xcom_15310	COG0251	oxidation-reduction process
Xcom_15320	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Xcom_15320	COG0392	lysyltransferase activity
Xcom_15355	COG2814	Major facilitator Superfamily
Xcom_15360	COG1902	pentaerythritol trinitrate reductase activity
Xcom_15370	COG2824	Alkylphosphonate utilization operon protein PhnA
Xcom_15380	COG1047	Peptidyl-prolyl cis-trans
Xcom_15405	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Xcom_15415	COG5487	UPF0391 membrane protein
Xcom_15420	COG1451	nucleotide metabolic process
Xcom_15445	COG0183	Belongs to the thiolase family
Xcom_15465	COG0745	RESPONSE REGULATOR receiver
Xcom_15465	COG3706	GGDEF domain
Xcom_15485	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Xcom_15485	COG1793	dna ligase
Xcom_15495	COG1793	dna ligase
Xcom_15500	COG1201	RNA secondary structure unwinding
Xcom_15510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Xcom_15515	COG1278	Cold shock
Xcom_15530	COG1472	Belongs to the glycosyl hydrolase 3 family
Xcom_15535	COG3046	protein related to deoxyribodipyrimidine photolyase
Xcom_15540	COG1233	COG1233 Phytoene dehydrogenase and related
Xcom_15545	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Xcom_15555	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Xcom_15570	COG1381	Involved in DNA repair and RecF pathway recombination
Xcom_15580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Xcom_15585	COG0571	ribonuclease III activity
Xcom_15600	COG0481	GTPase activity
Xcom_15605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Xcom_15620	COG1250	3-hydroxyacyl-CoA dehydrogenase
Xcom_15620	COG1024	Enoyl-CoA hydratase
Xcom_15645	COG1024	Enoyl-CoA hydratase
Xcom_15650	COG1960	acyl-CoA dehydrogenase activity
Xcom_15670	COG3867	Arabinogalactan endo-beta-1,4-galactanase
Xcom_15675	COG3250	beta-galactosidase activity
Xcom_15695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Xcom_15705	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Xcom_15725	COG3291	Pkd domain containing protein
Xcom_15725	COG3525	Glycosyl hydrolase, family 20, catalytic domain
Xcom_15745	COG0606	chelatase, subunit chli
Xcom_15760	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Xcom_15800	COG1690	Belongs to the RtcB family
Xcom_15835	COG1090	epimerase
Xcom_15840	COG0745	RESPONSE REGULATOR receiver
Xcom_15845	COG0642	Histidine kinase
Xcom_15865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Xcom_15890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Xcom_15895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Xcom_15910	COG0753	catalase activity
Xcom_15925	COG2197	response regulator
Xcom_15930	COG4585	Histidine kinase
Xcom_15935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xcom_15940	COG1136	(ABC) transporter
Xcom_15965	COG0697	spore germination
Xcom_15985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Xcom_15990	COG0180	Tryptophanyl-tRNA synthetase
Xcom_15995	COG3237	CsbD-like
Xcom_16040	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Xcom_16055	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Xcom_16060	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Xcom_16060	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Xcom_16090	COG2205	protein histidine kinase activity
Xcom_16095	COG0745	RESPONSE REGULATOR receiver
Xcom_16105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Xcom_16140	COG1199	ATP-dependent helicase activity
Xcom_16155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Xcom_16205	COG0625	glutathione transferase activity
Xcom_16240	COG4555	ABC transporter
Xcom_16250	COG1476	TRANSCRIPTIONal
Xcom_16275	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Xcom_16280	COG1131	(ABC) transporter
Xcom_16285	COG0842	Transport permease protein
Xcom_16290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Xcom_16320	COG1309	transcriptional regulator
Xcom_16325	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_16330	COG0308	aminopeptidase N
Xcom_16335	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Xcom_16345	COG0330	HflC and HflK could
Xcom_16350	COG0330	HflC and HflK could
Xcom_16370	COG0678	peroxiredoxin activity
Xcom_16380	COG4953	penicillin-binding protein 1C
Xcom_16400	COG2373	Large extracellular alpha-helical protein
Xcom_16445	COG3829	transcription factor binding
Xcom_16475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Xcom_16480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Xcom_16490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Xcom_16510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Xcom_16515	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Xcom_16520	COG1399	metal-binding, possibly nucleic acid-binding protein
Xcom_16525	COG0424	maF-like protein
Xcom_16535	COG0714	Associated with various cellular activities
Xcom_16555	COG0537	adenosine 5'-monophosphoramidase activity
Xcom_16560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Xcom_16565	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Xcom_16610	COG0314	molybdopterin synthase activity
Xcom_16615	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Xcom_16620	COG0315	cyclic pyranopterin monophosphate synthase activity
Xcom_16630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Xcom_16635	COG1234	tRNA 3'-trailer cleavage
Xcom_16640	COG3642	lipopolysaccharide core region biosynthetic process
Xcom_16645	COG0859	PFAM glycosyl transferase family 9
Xcom_16660	COG0631	protein serine/threonine phosphatase activity
Xcom_16665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Xcom_16670	COG0328	RNA-DNA hybrid ribonuclease activity
Xcom_16680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Xcom_16690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Xcom_16715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Xcom_16720	COG0740	serine-type endopeptidase activity
Xcom_16725	COG0544	peptidyl-prolyl cis-trans isomerase activity
Xcom_16765	COG0473	3-isopropylmalate dehydrogenase activity
Xcom_16780	COG4783	chaperone-mediated protein folding
Xcom_16795	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Xcom_16805	COG0438	transferase activity, transferring glycosyl groups
Xcom_16810	COG0671	phosphoesterase, PA-phosphatase related
Xcom_16815	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Xcom_16825	COG3291	Pkd domain containing protein
Xcom_16830	COG2833	Protein of unknown function (DUF455)
Xcom_16855	COG0285	dihydrofolate synthase activity
Xcom_16860	COG0406	alpha-ribazole phosphatase activity
Xcom_16885	COG1063	alcohol dehydrogenase
Xcom_16900	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Xcom_16905	COG4208	sulfate ABC transporter
Xcom_16910	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Xcom_16915	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Xcom_16920	COG0156	8-amino-7-oxononanoate synthase activity
Xcom_16940	COG2885	chlorophyll binding
Xcom_16945	COG0604	alcohol dehydrogenase
Xcom_16950	COG1902	pentaerythritol trinitrate reductase activity
Xcom_16950	COG0446	pyridine nucleotide-disulphide oxidoreductase
Xcom_16970	COG0625	glutathione transferase activity
Xcom_16975	COG0039	L-malate dehydrogenase activity
Xcom_16980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Xcom_16995	COG0154	amidase activity
Xcom_17005	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Xcom_17025	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Xcom_17030	COG0203	ribosomal protein L17
Xcom_17035	COG0202	RNA polymerase activity
Xcom_17040	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Xcom_17045	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Xcom_17050	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Xcom_17055	COG0201	protein transport
Xcom_17060	COG0200	Binds to the 23S rRNA
Xcom_17065	COG1841	ribosomal large subunit assembly
Xcom_17070	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Xcom_17075	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Xcom_17080	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Xcom_17085	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Xcom_17090	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Xcom_17095	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Xcom_17100	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Xcom_17105	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Xcom_17110	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Xcom_17115	COG0255	Belongs to the universal ribosomal protein uL29 family
Xcom_17120	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Xcom_17125	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Xcom_17130	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Xcom_17135	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Xcom_17140	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Xcom_17150	COG0088	Forms part of the polypeptide exit tunnel
Xcom_17155	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Xcom_17160	COG0051	transcription antitermination factor activity, RNA binding
Xcom_17175	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Xcom_17180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Xcom_17185	COG0049	tRNA binding
Xcom_17190	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Xcom_17195	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Xcom_17200	COG0085	RNA polymerase activity
Xcom_17205	COG0222	ribosome binding
Xcom_17210	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Xcom_17215	COG0081	regulation of translation
Xcom_17220	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Xcom_17225	COG0250	Participates in transcription elongation, termination and antitermination
Xcom_17230	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Xcom_17240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Xcom_17260	COG0012	GTP binding
Xcom_17265	COG0193	aminoacyl-tRNA hydrolase activity
Xcom_17270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Xcom_17275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Xcom_17285	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Xcom_17290	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
Xcom_17300	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Xcom_17305	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Xcom_17315	COG0521	Mo-molybdopterin cofactor biosynthetic process
Xcom_17330	COG1254	Belongs to the acylphosphatase family
Xcom_17335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Xcom_17340	COG1295	ribonuclease BN
Xcom_17365	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Xcom_17370	COG1404	Belongs to the peptidase S8 family
Xcom_17375	COG1404	Belongs to the peptidase S8 family
Xcom_17380	COG1404	Belongs to the peptidase S8 family
Xcom_17385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Xcom_17400	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Xcom_17405	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Xcom_17425	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Xcom_17445	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Xcom_17445	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Xcom_17465	COG2890	protein-(glutamine-N5) methyltransferase activity
Xcom_17475	COG3634	alkyl hydroperoxide reductase activity
Xcom_17480	COG0583	DNA-binding transcription factor activity
Xcom_17490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Xcom_17495	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Xcom_17510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Xcom_17520	COG2197	response regulator
Xcom_17545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Xcom_17555	COG0697	spore germination
Xcom_17575	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Xcom_17585	COG3386	PFAM SMP-30 Gluconolaconase
Xcom_17605	COG1024	Enoyl-CoA hydratase
Xcom_17615	COG0318	PFAM AMP-dependent synthetase and ligase
Xcom_17620	COG0583	DNA-binding transcription factor activity
Xcom_17625	COG3384	dioxygenase
Xcom_17655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Xcom_17660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Xcom_17675	COG2096	Adenosyltransferase
Xcom_17680	COG0123	including yeast histone deacetylase and acetoin utilization protein
Xcom_17685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Xcom_17690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Xcom_17695	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Xcom_17700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Xcom_17705	COG2967	ApaG domain
Xcom_17710	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Xcom_17725	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Xcom_17730	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Xcom_17750	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Xcom_17775	COG4181	ATPase activity
Xcom_17785	COG2175	clavaminate synthase activity
Xcom_17795	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Xcom_17800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Xcom_17820	COG4771	TonB-dependent receptor
Xcom_17830	COG0667	Aldo Keto reductase
Xcom_17835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Xcom_17840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Xcom_17850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Xcom_17855	COG4106	trans-aconitate 2-methyltransferase activity
Xcom_17865	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Xcom_17905	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Xcom_17915	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Xcom_17920	COG2226	methyltransferase
Xcom_17950	COG0366	Alpha amylase catalytic
Xcom_17975	COG3321	synthase
Xcom_17975	COG0604	alcohol dehydrogenase
Xcom_17975	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_17985	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Xcom_17995	COG0494	nUDIX hydrolase
Xcom_18005	COG0653	protein targeting
Xcom_18010	COG0739	heme binding
Xcom_18020	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Xcom_18035	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Xcom_18040	COG1181	Belongs to the D-alanine--D-alanine ligase family
Xcom_18045	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Xcom_18050	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Xcom_18060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Xcom_18065	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Xcom_18070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Xcom_18085	COG3116	cell division
Xcom_18090	COG0275	rRNA processing
Xcom_18095	COG2001	Belongs to the MraZ family
Xcom_18130	COG0792	nuclease activity
Xcom_18135	COG1988	membrane-bound metal-dependent
Xcom_18140	COG0277	FAD linked oxidase domain protein
Xcom_18150	COG0745	RESPONSE REGULATOR receiver
Xcom_18155	COG2205	protein histidine kinase activity
Xcom_18165	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Xcom_18170	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Xcom_18195	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Xcom_18200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Xcom_18205	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Xcom_18225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Xcom_18225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Xcom_18235	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Xcom_18240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Xcom_18250	COG0488	(ABC) transporter
Xcom_18260	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Xcom_18265	COG3791	Glutathione-dependent formaldehyde-activating
Xcom_18290	COG0745	RESPONSE REGULATOR receiver
Xcom_18295	COG2205	protein histidine kinase activity
Xcom_18305	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Xcom_18335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Xcom_18340	COG1012	belongs to the aldehyde dehydrogenase family
Xcom_18345	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Xcom_18350	COG0617	tRNA 3'-terminal CCA addition
Xcom_18365	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Xcom_18370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Xcom_18375	COG1609	Transcriptional regulator
Xcom_18410	COG4795	General secretion pathway protein
Xcom_18430	COG1459	type II secretion system
Xcom_18485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Xcom_18490	COG4191	Histidine kinase
Xcom_18495	COG0784	Response regulator, receiver
Xcom_18500	COG4251	negative regulation of phosphorylation
Xcom_18505	COG2823	Periplasmic or secreted lipoprotein
Xcom_18510	COG0673	inositol 2-dehydrogenase activity
Xcom_18515	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Xcom_18550	COG1056	cytidyltransferase-related domain
Xcom_18550	COG1051	belongs to the nudix hydrolase family
Xcom_18560	COG0583	DNA-binding transcription factor activity
Xcom_18575	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Xcom_18580	COG0321	lipoyl(octanoyl) transferase activity
Xcom_18585	COG2921	Belongs to the UPF0250 family
Xcom_18600	COG1686	Belongs to the peptidase S11 family
Xcom_18610	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Xcom_18615	COG2951	lytic endotransglycosylase activity
Xcom_18630	COG0772	Belongs to the SEDS family
Xcom_18645	COG1792	Involved in formation and maintenance of cell shape
Xcom_18650	COG1077	Cell shape determining protein MreB Mrl
Xcom_18660	COG3284	Transcriptional regulator
Xcom_18670	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Xcom_18710	COG0308	aminopeptidase N
Xcom_18715	COG5001	Diguanylate cyclase
Xcom_18715	COG3300	MHYT domain
Xcom_18745	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Xcom_18750	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Xcom_18755	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Xcom_18765	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Xcom_18775	COG2832	Protein of unknown function (DUF454)
Xcom_18795	COG1505	serine-type exopeptidase activity
Xcom_18835	COG0181	hydroxymethylbilane synthase activity
Xcom_18845	COG3275	phosphorelay sensor kinase activity
Xcom_18855	COG2943	transferase activity, transferring hexosyl groups
Xcom_18875	COG3706	GGDEF domain
Xcom_18880	COG0659	secondary active sulfate transmembrane transporter activity
Xcom_18885	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Xcom_18885	COG5297	Belongs to the glycosyl hydrolase family 6
Xcom_18890	COG0840	transmembrane signaling receptor activity
Xcom_18925	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
Xcom_18935	COG2801	Transposase and inactivated derivatives
Xcom_18945	COG0598	Magnesium transport protein CorA
Xcom_18955	COG1113	amino acid transport
Xcom_18975	COG0697	spore germination
Xcom_19000	COG1959	2 iron, 2 sulfur cluster binding
Xcom_19005	COG3706	GGDEF domain
Xcom_19030	COG2409	Drug exporters of the RND superfamily
Xcom_19055	COG0435	Glutathione S-transferase
Xcom_19065	COG4221	oxidoreductase activity
Xcom_19105	COG4221	oxidoreductase activity
Xcom_19170	COG0546	phosphoglycolate phosphatase activity
Xcom_19175	COG1802	Transcriptional regulator
Xcom_19185	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Xcom_19190	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
Xcom_19210	COG3052	prosthetic group binding
Xcom_19240	COG2353	YceI-like domain
Xcom_19245	COG0778	Nitroreductase
Xcom_19270	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Xcom_19275	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Xcom_19285	COG3386	PFAM SMP-30 Gluconolaconase
Xcom_19300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Xcom_19315	COG0459	protein refolding
Xcom_19320	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Xcom_19330	COG2356	endonuclease I
Xcom_19340	COG1324	tolerance protein
Xcom_19350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Xcom_19355	COG0511	ligase activity, forming carbon-carbon bonds
Xcom_19365	COG0439	Biotin carboxylase
Xcom_19390	COG2264	protein methyltransferase activity
Xcom_19420	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Xcom_19425	COG4589	Belongs to the CDS family
Xcom_19450	COG2453	phosphatase
Xcom_19450	COG0671	phosphoesterase, PA-phosphatase related
Xcom_19455	COG2267	carboxylic ester hydrolase activity
Xcom_19460	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Xcom_19465	COG0138	bifunctional purine biosynthesis protein purh
Xcom_19475	COG0151	Belongs to the GarS family
Xcom_19480	COG1289	transmembrane transporter activity
Xcom_19485	COG2814	Major facilitator Superfamily
Xcom_19495	COG2814	Major facilitator Superfamily
Xcom_19515	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Xcom_19535	COG0316	Belongs to the HesB IscA family
Xcom_19580	COG1051	belongs to the nudix hydrolase family
Xcom_19595	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Xcom_19600	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Xcom_19605	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Xcom_19615	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Xcom_19620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Xcom_19630	COG0134	indole-3-glycerol-phosphate synthase activity
Xcom_19635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Xcom_19665	COG1597	lipid kinase activity
Xcom_19670	COG0456	acetyltransferase
Xcom_19680	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Xcom_19685	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Xcom_19705	COG3179	chitinase
Xcom_19730	COG2111	Na H antiporter
Xcom_19730	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Xcom_19735	COG1006	Multisubunit Na H antiporter MnhC subunit
Xcom_19740	COG0651	ATP synthesis coupled electron transport
Xcom_19750	COG2212	antiporter activity
Xcom_19755	COG1320	monovalent cation:proton antiporter activity
Xcom_19770	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
Xcom_19775	COG2852	Protein conserved in bacteria
Xcom_19795	COG3104	oligopeptide transport
Xcom_19800	COG3483	tryptophan 2,3-dioxygenase activity
Xcom_19810	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Xcom_19825	COG0508	dehydrogenase complex catalyzes the overall conversion of
Xcom_19845	COG0513	Belongs to the DEAD box helicase family
Xcom_19860	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_19865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Xcom_19900	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_19905	COG0702	epimerase
Xcom_19930	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Xcom_19935	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Xcom_19940	COG0297	glycogen (starch) synthase activity
Xcom_19945	COG3706	GGDEF domain
Xcom_19945	COG0745	RESPONSE REGULATOR receiver
Xcom_19950	COG2354	Protein conserved in bacteria
Xcom_19960	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Xcom_19970	COG1368	sulfuric ester hydrolase activity
Xcom_19975	COG3264	Mechanosensitive ion channel
Xcom_19975	COG1511	domain protein
Xcom_20045	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Xcom_20105	COG2801	Transposase and inactivated derivatives
Xcom_20135	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Xcom_20145	COG1040	competence protein
Xcom_20150	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Xcom_20155	COG0156	8-amino-7-oxononanoate synthase activity
Xcom_20165	COG2267	carboxylic ester hydrolase activity
Xcom_20170	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_20210	COG0445	tRNA wobble uridine modification
Xcom_20230	COG1414	Transcriptional regulator
Xcom_20245	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Xcom_20250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Xcom_20260	COG3485	protocatechuate 3,4-dioxygenase
Xcom_20265	COG3485	protocatechuate 3,4-dioxygenase
Xcom_20275	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Xcom_20280	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Xcom_20305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Xcom_20310	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Xcom_20360	COG0129	dihydroxy-acid dehydratase activity
Xcom_20375	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Xcom_20420	COG1733	regulation of RNA biosynthetic process
Xcom_20425	COG0702	epimerase
Xcom_20465	COG0583	DNA-binding transcription factor activity
Xcom_20470	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Xcom_20485	COG1538	Outer membrane efflux protein
Xcom_20495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xcom_20500	COG2205	protein histidine kinase activity
Xcom_20505	COG0745	RESPONSE REGULATOR receiver
Xcom_20525	COG1902	pentaerythritol trinitrate reductase activity
Xcom_20530	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Xcom_20535	COG2267	carboxylic ester hydrolase activity
Xcom_20545	COG2814	Major facilitator Superfamily
Xcom_20550	COG0583	DNA-binding transcription factor activity
Xcom_20565	COG0084	hydrolase, TatD family'
Xcom_20590	COG2252	PERMEase
Xcom_20635	COG0583	DNA-binding transcription factor activity
Xcom_20645	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Xcom_20665	COG2072	flavoprotein involved in K transport
Xcom_20670	COG2351	hydroxyisourate hydrolase activity
Xcom_20675	COG4807	Protein conserved in bacteria
Xcom_20685	COG1643	Atp-dependent helicase
Xcom_20695	COG1187	pseudouridine synthase activity
Xcom_20710	COG2130	NADP-dependent
Xcom_20730	COG1764	response to oxidative stress
Xcom_20735	COG1846	Transcriptional regulator
Xcom_20740	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Xcom_20750	COG0697	spore germination
Xcom_20765	COG0523	cobalamin synthesis protein
Xcom_20820	COG1960	acyl-CoA dehydrogenase activity
Xcom_20825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Xcom_20855	COG3706	GGDEF domain
Xcom_20860	COG2224	Isocitrate lyase
Xcom_20865	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Xcom_20870	COG0583	DNA-binding transcription factor activity
Xcom_20875	COG0475	glutathione-regulated potassium exporter activity
Xcom_20930	COG0564	pseudouridine synthase activity
Xcom_20970	COG1309	transcriptional regulator
Xcom_20980	COG1028	Short-chain dehydrogenase reductase Sdr
Xcom_21035	COG1074	ATP-dependent DNA helicase activity
Xcom_21040	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Xcom_21075	COG1127	ABC transporter
Xcom_21080	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Xcom_21085	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Xcom_21100	COG2853	Lipoprotein
Xcom_21110	COG0386	Belongs to the glutathione peroxidase family
Xcom_21120	COG1322	Protein conserved in bacteria
Xcom_21125	COG0604	alcohol dehydrogenase
Xcom_21130	COG0583	DNA-binding transcription factor activity
Xcom_21155	COG0531	amino acid
Xcom_21160	COG3537	Alpha-1,2-mannosidase
Xcom_21175	COG2203	Gaf domain
Xcom_21175	COG2199	diguanylate cyclase activity
Xcom_21180	COG3835	regulator
Xcom_21185	COG1929	Belongs to the glycerate kinase type-1 family
Xcom_21190	COG2271	Major facilitator Superfamily
Xcom_21205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Xcom_21215	COG0861	Integral membrane protein TerC family
Xcom_21230	COG0584	glycerophosphoryl diester phosphodiesterase
Xcom_21250	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Xcom_21255	COG0726	polysaccharide deacetylase
Xcom_21260	COG0706	membrane insertase activity
Xcom_21265	COG0594	ribonuclease P activity
Xcom_21270	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Xcom_21285	COG2951	lytic endotransglycosylase activity
Xcom_21440	COG0489	protein tyrosine kinase activity