locus-tag	class	description
XAV_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XAV_00020	COG0187	DNA topoisomerase II activity
XAV_00030	COG0501	Belongs to the peptidase M48B family
XAV_00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XAV_00120	COG0793	Belongs to the peptidase S41A family
XAV_00125	COG4942	peptidase
XAV_00135	COG2234	aminopeptidase activity
XAV_00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAV_00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAV_00165	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAV_00170	COG1064	alcohol dehydrogenase
XAV_00200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XAV_00250	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XAV_00255	COG1902	pentaerythritol trinitrate reductase activity
XAV_00300	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XAV_00305	COG0583	DNA-binding transcription factor activity
XAV_00340	COG0702	epimerase
XAV_00345	COG1733	regulation of RNA biosynthetic process
XAV_00380	COG0129	dihydroxy-acid dehydratase activity
XAV_00395	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XAV_00425	COG3039	Transposase
XAV_00470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XAV_00475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XAV_00505	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XAV_00515	COG3485	protocatechuate 3,4-dioxygenase
XAV_00520	COG3485	protocatechuate 3,4-dioxygenase
XAV_00530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XAV_00535	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XAV_00570	COG0493	'glutamate synthase
XAV_00575	COG0067	glutamate synthase
XAV_00575	COG0069	glutamate synthase activity
XAV_00575	COG0070	glutamate synthase
XAV_00610	COG2937	Belongs to the GPAT DAPAT family
XAV_00640	COG0284	orotidine-5'-phosphate decarboxylase activity
XAV_00645	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
XAV_00650	COG3132	Protein of unknown function, DUF480
XAV_00670	COG0210	DNA helicase
XAV_00675	COG1435	thymidine kinase activity
XAV_00685	COG3039	Transposase
XAV_00720	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XAV_00745	COG1304	FMN binding
XAV_00785	COG4772	TonB-dependent receptor
XAV_00795	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XAV_00855	COG2211	Major facilitator Superfamily
XAV_00870	COG3693	PFAM glycoside hydrolase, family 10
XAV_00875	COG3693	PFAM glycoside hydrolase, family 10
XAV_00905	COG3039	Transposase
XAV_00930	COG1472	Belongs to the glycosyl hydrolase 3 family
XAV_00935	COG3507	Belongs to the glycosyl hydrolase 43 family
XAV_00950	COG3661	Belongs to the glycosyl hydrolase 67 family
XAV_00960	COG2115	Belongs to the xylose isomerase family
XAV_00965	COG0037	tRNA processing
XAV_00970	COG2974	May be involved in recombination
XAV_00985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XAV_00995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XAV_01000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XAV_01005	COG0805	protein transport
XAV_01015	COG0519	Catalyzes the synthesis of GMP from XMP
XAV_01015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XAV_01025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XAV_01040	COG0457	Tetratricopeptide repeat
XAV_01045	COG4771	TonB-dependent receptor
XAV_01050	COG0729	surface antigen
XAV_01055	COG2911	Protein conserved in bacteria
XAV_01065	COG0443	Heat shock 70 kDa protein
XAV_01090	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAV_01095	COG3265	gluconokinase activity
XAV_01100	COG2211	Major facilitator Superfamily
XAV_01105	COG3459	Glycosyltransferase 36 associated
XAV_01115	COG2205	protein histidine kinase activity
XAV_01120	COG1971	Probably functions as a manganese efflux pump
XAV_01130	COG1917	Cupin 2, conserved barrel domain protein
XAV_01130	COG2207	Transcriptional regulator
XAV_01135	COG1414	Transcriptional regulator
XAV_01155	COG0179	Fumarylacetoacetate (FAA) hydrolase
XAV_01160	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_01160	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_01200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XAV_01215	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XAV_01220	COG0708	Exodeoxyribonuclease III
XAV_01235	COG2091	lysine biosynthetic process via aminoadipic acid
XAV_01245	COG3540	Alkaline phosphatase
XAV_01250	COG0357	Ribosomal RNA small subunit methyltransferase G
XAV_01295	COG2159	amidohydrolase
XAV_01305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XAV_01315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAV_01330	COG0210	DNA helicase
XAV_01380	COG2814	Major facilitator Superfamily
XAV_01420	COG1272	protein, Hemolysin III
XAV_01425	COG1205	dead DEAH box helicase
XAV_01425	COG1111	helicase
XAV_01490	COG1414	Transcriptional regulator
XAV_01505	COG0445	tRNA wobble uridine modification
XAV_01545	COG2267	carboxylic ester hydrolase activity
XAV_01555	COG0156	8-amino-7-oxononanoate synthase activity
XAV_01560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XAV_01565	COG1040	competence protein
XAV_01570	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XAV_01655	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XAV_01715	COG3039	Transposase
XAV_01725	COG3264	Mechanosensitive ion channel
XAV_01725	COG1511	domain protein
XAV_01740	COG3039	Transposase
XAV_01790	COG3210	domain, Protein
XAV_01795	COG2831	hemolysin activation secretion protein
XAV_01825	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XAV_01830	COG2354	Protein conserved in bacteria
XAV_01850	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XAV_01855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XAV_01880	COG0702	epimerase
XAV_01895	COG1858	cytochrome C peroxidase
XAV_01950	COG3039	Transposase
XAV_02005	COG0513	Belongs to the DEAD box helicase family
XAV_02035	COG3483	tryptophan 2,3-dioxygenase activity
XAV_02040	COG3104	oligopeptide transport
XAV_02060	COG2852	Protein conserved in bacteria
XAV_02065	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
XAV_02085	COG1320	monovalent cation:proton antiporter activity
XAV_02090	COG2212	antiporter activity
XAV_02100	COG0651	ATP synthesis coupled electron transport
XAV_02105	COG1006	Multisubunit Na H antiporter MnhC subunit
XAV_02110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XAV_02110	COG2111	Na H antiporter
XAV_02145	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XAV_02165	COG1597	lipid kinase activity
XAV_02185	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XAV_02220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XAV_02225	COG0134	indole-3-glycerol-phosphate synthase activity
XAV_02235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XAV_02240	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XAV_02250	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XAV_02260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XAV_02275	COG1051	belongs to the nudix hydrolase family
XAV_02315	COG0316	Belongs to the HesB IscA family
XAV_02330	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XAV_02345	COG2814	Major facilitator Superfamily
XAV_02355	COG2814	Major facilitator Superfamily
XAV_02360	COG1289	transmembrane transporter activity
XAV_02380	COG0577	efflux transmembrane transporter activity
XAV_02380	COG1136	(ABC) transporter
XAV_02385	COG0151	Belongs to the GarS family
XAV_02390	COG0138	bifunctional purine biosynthesis protein purh
XAV_02405	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XAV_02425	COG2264	protein methyltransferase activity
XAV_02440	COG0439	Biotin carboxylase
XAV_02450	COG0511	ligase activity, forming carbon-carbon bonds
XAV_02455	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XAV_02470	COG1324	tolerance protein
XAV_02485	COG0459	protein refolding
XAV_02505	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XAV_02520	COG3386	PFAM SMP-30 Gluconolaconase
XAV_02530	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XAV_02575	COG0778	Nitroreductase
XAV_02580	COG2353	YceI-like domain
XAV_02605	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XAV_02685	COG2375	cellular response to nickel ion
XAV_02740	COG1063	alcohol dehydrogenase
XAV_02770	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_02790	COG1271	oxidase subunit
XAV_02800	COG2204	response regulator
XAV_02835	COG3546	catalase activity
XAV_02840	COG3685	Protein conserved in bacteria
XAV_02870	COG0531	amino acid
XAV_02890	COG3590	peptidase
XAV_02900	COG0667	Aldo Keto reductase
XAV_02920	COG3384	dioxygenase
XAV_02930	COG1573	uracil-dna glycosylase
XAV_02935	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XAV_02940	COG0025	NhaP-type Na H and K H
XAV_02945	COG1131	(ABC) transporter
XAV_02950	COG0842	Transport permease protein
XAV_03005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAV_03010	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XAV_03030	COG2202	Pas domain
XAV_03030	COG2205	protein histidine kinase activity
XAV_03050	COG2813	Specifically methylates the guanine in position
XAV_03055	COG1187	pseudouridine synthase activity
XAV_03060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XAV_03095	COG1666	GTP binding
XAV_03100	COG0697	spore germination
XAV_03105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XAV_03110	COG2011	ABC-type metal ion transport system permease component
XAV_03145	COG0508	dehydrogenase complex catalyzes the overall conversion of
XAV_03155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XAV_03175	COG0356	it plays a direct role in the translocation of protons across the membrane
XAV_03190	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XAV_03195	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XAV_03200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XAV_03205	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XAV_03210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XAV_03225	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XAV_03240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XAV_03290	COG2132	Multicopper oxidase
XAV_03305	COG0339	signal peptide processing
XAV_03325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XAV_03330	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XAV_03345	COG1956	GAF domain-containing protein
XAV_03350	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XAV_03360	COG0720	synthase
XAV_03365	COG0513	Belongs to the DEAD box helicase family
XAV_03410	COG0626	cystathionine gamma-synthase activity
XAV_03430	COG1216	Glycosyl transferase, family 2
XAV_03430	COG0438	transferase activity, transferring glycosyl groups
XAV_03470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XAV_03485	COG0277	FAD linked oxidase domain protein
XAV_03490	COG0546	phosphoglycolate phosphatase activity
XAV_03490	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XAV_03505	COG2086	electron transfer activity
XAV_03535	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XAV_03535	COG0662	Cupin 2, conserved barrel domain protein
XAV_03540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XAV_03575	COG3218	ABC-type transport auxiliary lipoprotein component
XAV_03575	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XAV_03580	COG1127	ABC transporter
XAV_03585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XAV_03600	COG0442	prolyl-tRNA aminoacylation
XAV_03610	COG1183	phosphatidylcholine synthase activity
XAV_03645	COG0525	valine-tRNA ligase activity
XAV_03665	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XAV_03675	COG0795	lipopolysaccharide-transporting ATPase activity
XAV_03690	COG4974	Belongs to the 'phage' integrase family
XAV_03715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XAV_03720	COG0047	phosphoribosylformylglycinamidine synthase activity
XAV_03720	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XAV_03730	COG5295	Hep Hag repeat protein
XAV_03735	COG1404	Belongs to the peptidase S8 family
XAV_03750	COG1404	Belongs to the peptidase S8 family
XAV_03755	COG1404	Belongs to the peptidase S8 family
XAV_03760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XAV_03765	COG1459	type II secretion system
XAV_03770	COG2165	general secretion pathway protein
XAV_03775	COG4970	Tfp pilus assembly protein FimT
XAV_03780	COG2165	general secretion pathway protein
XAV_03785	COG4795	General secretion pathway protein
XAV_03790	COG3156	type II secretion system protein K
XAV_03795	COG3166	PFAM Fimbrial assembly family protein
XAV_03810	COG1450	Type ii and iii secretion system protein
XAV_03820	COG2188	Transcriptional regulator
XAV_03865	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XAV_03905	COG0242	peptide deformylase activity
XAV_03910	COG1307	EDD domain protein, DegV family
XAV_03955	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XAV_03980	COG1162	GTPase activity
XAV_04005	COG2211	Major facilitator Superfamily
XAV_04015	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_04020	COG2851	Citrate transporter
XAV_04035	COG0642	Histidine kinase
XAV_04045	COG2197	response regulator
XAV_04060	COG0667	Aldo Keto reductase
XAV_04065	COG0583	DNA-binding transcription factor activity
XAV_04095	COG1301	dicarboxylic acid transport
XAV_04100	COG0281	malic enzyme
XAV_04100	COG0280	phosphate acetyltransferase
XAV_04170	COG1560	Kdo2-lipid A biosynthetic process
XAV_04175	COG1519	Transferase
XAV_04180	COG1538	Outer membrane efflux protein
XAV_04185	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XAV_04215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XAV_04220	COG0066	3-isopropylmalate dehydratase activity
XAV_04230	COG0473	3-isopropylmalate dehydrogenase activity
XAV_04235	COG4771	TonB-dependent receptor
XAV_04240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XAV_04260	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XAV_04270	COG0840	transmembrane signaling receptor activity
XAV_04280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XAV_04285	COG3710	Transcriptional regulator
XAV_04305	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XAV_04315	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XAV_04370	COG0563	adenylate kinase activity
XAV_04375	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XAV_04385	COG3781	membrane
XAV_04390	COG0671	phosphoesterase, PA-phosphatase related
XAV_04420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XAV_04450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XAV_04455	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
XAV_04465	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XAV_04475	COG0352	thiamine-phosphate diphosphorylase activity
XAV_04485	COG2912	Transglutaminase-like superfamily
XAV_04495	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XAV_04505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XAV_04525	COG3079	Belongs to the UPF0149 family
XAV_04530	COG0006	proline dipeptidase activity
XAV_04540	COG0006	proline dipeptidase activity
XAV_04555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XAV_04560	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XAV_04570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XAV_04575	COG1561	YicC-like family, N-terminal region
XAV_04590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XAV_04600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XAV_04605	COG1957	nucleoside hydrolase
XAV_04625	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XAV_04655	COG0714	Associated with various cellular activities
XAV_04675	COG2304	oxidoreductase activity
XAV_04685	COG1301	dicarboxylic acid transport
XAV_04690	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XAV_04695	COG4773	Receptor
XAV_04700	COG0739	heme binding
XAV_04705	COG1376	ErfK ybiS ycfS ynhG family protein
XAV_04780	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XAV_04785	COG4149	molybdate abc transporter
XAV_04790	COG0725	ABC transporter, periplasmic molybdate-binding protein
XAV_04795	COG3453	Protein conserved in bacteria
XAV_04795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XAV_04810	COG3047	cAMP biosynthetic process
XAV_04820	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XAV_04850	COG0126	phosphoglycerate kinase activity
XAV_04860	COG0469	pyruvate kinase activity
XAV_04865	COG3588	fructose-bisphosphate aldolase
XAV_04870	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
XAV_04910	COG0784	Response regulator, receiver
XAV_04910	COG2198	Histidine kinase
XAV_04910	COG2205	protein histidine kinase activity
XAV_04930	COG0175	sulfate reduction
XAV_04935	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XAV_04940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XAV_04945	COG0175	sulfate reduction
XAV_04950	COG0529	Catalyzes the synthesis of activated sulfate
XAV_04950	COG2895	sulfate adenylyltransferase (ATP) activity
XAV_04960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XAV_04975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XAV_05015	COG1970	mechanosensitive ion channel activity
XAV_05035	COG3273	potassium ion transport
XAV_05035	COG0471	metal ion transport
XAV_05040	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XAV_05045	COG2022	thiamine diphosphate biosynthetic process
XAV_05100	COG0189	ligase activity
XAV_05110	COG0745	RESPONSE REGULATOR receiver
XAV_05140	COG0237	dephospho-CoA kinase activity
XAV_05145	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XAV_05180	COG0045	succinate-CoA ligase (ADP-forming) activity
XAV_05185	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XAV_05200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XAV_05200	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XAV_05210	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAV_05215	COG0564	pseudouridine synthase activity
XAV_05230	COG3011	Protein conserved in bacteria
XAV_05270	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XAV_05275	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XAV_05280	COG0537	adenosine 5'-monophosphoramidase activity
XAV_05300	COG0714	Associated with various cellular activities
XAV_05315	COG0424	maF-like protein
XAV_05320	COG1399	metal-binding, possibly nucleic acid-binding protein
XAV_05325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XAV_05330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XAV_05345	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_05360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XAV_05365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XAV_05395	COG3829	transcription factor binding
XAV_05455	COG0678	peroxiredoxin activity
XAV_05475	COG0330	HflC and HflK could
XAV_05480	COG0330	HflC and HflK could
XAV_05485	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XAV_05490	COG0308	aminopeptidase N
XAV_05515	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XAV_05540	COG1946	Acyl-CoA thioesterase
XAV_05545	COG1024	Enoyl-CoA hydratase
XAV_05555	COG0824	Thioesterase
XAV_05560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XAV_05565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XAV_05570	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XAV_05575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XAV_05580	COG0268	Binds directly to 16S ribosomal RNA
XAV_05590	COG0196	riboflavin kinase activity
XAV_05595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XAV_05600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XAV_05605	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XAV_05620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XAV_05625	COG1845	cytochrome c oxidase, subunit III
XAV_05630	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XAV_05645	COG3152	Membrane
XAV_05655	COG2207	Transcriptional regulator
XAV_05675	COG1366	Belongs to the anti-sigma-factor antagonist family
XAV_05680	COG1366	Belongs to the anti-sigma-factor antagonist family
XAV_05685	COG2172	sigma factor antagonist activity
XAV_05695	COG2205	protein histidine kinase activity
XAV_05715	COG3507	Belongs to the glycosyl hydrolase 43 family
XAV_05750	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XAV_05755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XAV_05765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XAV_05770	COG0228	four-way junction DNA binding
XAV_05775	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XAV_05780	COG0336	Belongs to the RNA methyltransferase TrmD family
XAV_05790	COG0534	Mate efflux family protein
XAV_05800	COG3039	Transposase
XAV_05825	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XAV_05840	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XAV_05900	COG3039	Transposase
XAV_05905	COG3250	beta-galactosidase activity
XAV_05910	COG3867	Arabinogalactan endo-beta-1,4-galactanase
XAV_05930	COG1960	acyl-CoA dehydrogenase activity
XAV_05935	COG1024	Enoyl-CoA hydratase
XAV_05955	COG1250	3-hydroxyacyl-CoA dehydrogenase
XAV_05955	COG1024	Enoyl-CoA hydratase
XAV_05970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XAV_05975	COG0481	GTPase activity
XAV_05990	COG0571	ribonuclease III activity
XAV_05995	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XAV_06000	COG1381	Involved in DNA repair and RecF pathway recombination
XAV_06010	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XAV_06015	COG2954	triphosphatase activity
XAV_06020	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XAV_06025	COG1233	COG1233 Phytoene dehydrogenase and related
XAV_06030	COG3046	protein related to deoxyribodipyrimidine photolyase
XAV_06035	COG1472	Belongs to the glycosyl hydrolase 3 family
XAV_06045	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XAV_06050	COG1278	Cold shock
XAV_06065	COG1201	RNA secondary structure unwinding
XAV_06070	COG1793	dna ligase
XAV_06080	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XAV_06080	COG1793	dna ligase
XAV_06110	COG0183	Belongs to the thiolase family
XAV_06130	COG1451	nucleotide metabolic process
XAV_06135	COG5487	UPF0391 membrane protein
XAV_06145	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XAV_06165	COG1047	Peptidyl-prolyl cis-trans
XAV_06175	COG2824	Alkylphosphonate utilization operon protein PhnA
XAV_06190	COG1902	pentaerythritol trinitrate reductase activity
XAV_06195	COG2814	Major facilitator Superfamily
XAV_06230	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XAV_06230	COG0392	lysyltransferase activity
XAV_06240	COG0251	oxidation-reduction process
XAV_06245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XAV_06285	COG1595	DNA-templated transcription, initiation
XAV_06300	COG2878	Part of a membrane complex involved in electron transport
XAV_06310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XAV_06310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XAV_06330	COG0346	lactoylglutathione lyase activity
XAV_06335	COG0833	amino acid
XAV_06340	COG2040	homocysteine
XAV_06350	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XAV_06420	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XAV_06455	COG1187	pseudouridine synthase activity
XAV_06475	COG0514	ATP-dependent DNA helicase (RecQ)
XAV_06490	COG0783	Belongs to the Dps family
XAV_06495	COG1643	Atp-dependent helicase
XAV_06520	COG0535	radical SAM domain protein
XAV_06525	COG0535	radical SAM domain protein
XAV_06530	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
XAV_06535	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
XAV_06545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XAV_06555	COG1215	transferase activity, transferring glycosyl groups
XAV_06560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XAV_06580	COG1199	ATP-dependent helicase activity
XAV_06600	COG0189	ligase activity
XAV_06615	COG0835	chemotaxis
XAV_06620	COG0840	transmembrane signaling receptor activity
XAV_06625	COG2198	Histidine kinase
XAV_06625	COG0784	Response regulator, receiver
XAV_06625	COG0643	Histidine kinase
XAV_06650	COG1446	asparaginase
XAV_06655	COG3142	Participates in the control of copper homeostasis
XAV_06695	COG3537	Alpha-1,2-mannosidase
XAV_06755	COG1472	Belongs to the glycosyl hydrolase 3 family
XAV_06765	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XAV_06770	COG1388	LysM domain
XAV_06770	COG3858	chitin binding
XAV_06785	COG0837	glucose binding
XAV_06800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XAV_06810	COG0494	nUDIX hydrolase
XAV_06820	COG3956	TIGRFAM MazG family protein
XAV_06825	COG1742	UPF0060 membrane protein
XAV_06840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XAV_06845	COG0509	glycine decarboxylation via glycine cleavage system
XAV_06875	COG1960	acyl-CoA dehydrogenase activity
XAV_06885	COG1309	transcriptional regulator
XAV_06890	COG4771	TonB-dependent receptor
XAV_06900	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XAV_06905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XAV_06910	COG0463	Glycosyl transferase, family 2
XAV_06925	COG1272	protein, Hemolysin III
XAV_06930	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XAV_06935	COG0739	heme binding
XAV_06940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XAV_06945	COG0626	cystathionine gamma-synthase activity
XAV_06950	COG0527	aspartate kinase activity
XAV_06950	COG0460	homoserine dehydrogenase
XAV_06960	COG1760	l-serine dehydratase
XAV_06980	COG2353	YceI-like domain
XAV_06985	COG2198	Histidine kinase
XAV_06985	COG2205	protein histidine kinase activity
XAV_06985	COG0784	Response regulator, receiver
XAV_07010	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XAV_07025	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XAV_07030	COG0259	pyridoxamine-phosphate oxidase activity
XAV_07040	COG1842	Phage shock protein A
XAV_07065	COG0754	glutathionylspermidine amidase activity
XAV_07160	COG0531	amino acid
XAV_07165	COG2197	response regulator
XAV_07170	COG2267	carboxylic ester hydrolase activity
XAV_07180	COG1113	amino acid transport
XAV_07195	COG1271	oxidase subunit
XAV_07200	COG1294	oxidase, subunit
XAV_07210	COG2239	Acts as a magnesium transporter
XAV_07215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XAV_07220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XAV_07315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XAV_07315	COG4651	solute:proton antiporter activity
XAV_07345	COG0488	(ABC) transporter
XAV_07385	COG0477	Major facilitator Superfamily
XAV_07400	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XAV_07415	COG0217	transcriptional regulatory protein
XAV_07420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XAV_07425	COG0632	four-way junction helicase activity
XAV_07430	COG3158	transport of potassium into the cell
XAV_07440	COG2255	four-way junction helicase activity
XAV_07445	COG0824	Thioesterase
XAV_07455	COG0848	biopolymer transport protein
XAV_07465	COG0823	Involved in the tonB-independent uptake of proteins
XAV_07470	COG2885	chlorophyll binding
XAV_07480	COG0602	queuosine metabolic process
XAV_07520	COG0825	malonyl-CoA metabolic process
XAV_07535	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAV_07540	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAV_07545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XAV_07550	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAV_07565	COG0750	zinc metalloprotease
XAV_07570	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XAV_07575	COG0575	Belongs to the CDS family
XAV_07580	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XAV_07585	COG0233	cytoplasmic translational termination
XAV_07590	COG0528	UMP kinase activity
XAV_07600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XAV_07605	COG0052	Belongs to the universal ribosomal protein uS2 family
XAV_07645	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XAV_07655	COG1393	Belongs to the ArsC family
XAV_07665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XAV_07670	COG0367	asparagine synthase
XAV_07680	COG4774	siderophore transport
XAV_07720	COG1566	PFAM secretion protein HlyD family protein
XAV_07725	COG2814	Major facilitator Superfamily
XAV_07800	COG0386	Belongs to the glutathione peroxidase family
XAV_07855	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XAV_07860	COG0084	hydrolase, TatD family'
XAV_07890	COG0367	asparagine synthase
XAV_07900	COG0305	Participates in initiation and elongation during chromosome replication
XAV_07905	COG0415	Belongs to the DNA photolyase family
XAV_07935	COG3706	GGDEF domain
XAV_07945	COG3706	GGDEF domain
XAV_07960	COG3293	Transposase
XAV_07980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XAV_08030	COG2801	Transposase and inactivated derivatives
XAV_08070	COG0582	viral genome integration into host DNA
XAV_08085	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XAV_08100	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAV_08110	COG0497	DNA recombination
XAV_08115	COG1420	regulation of RNA biosynthetic process
XAV_08120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XAV_08125	COG0443	Heat shock 70 kDa protein
XAV_08130	COG0484	heat shock protein binding
XAV_08135	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XAV_08170	COG1132	(ABC) transporter
XAV_08205	COG2850	peptidyl-arginine hydroxylation
XAV_08230	COG1253	flavin adenine dinucleotide binding
XAV_08260	COG1131	(ABC) transporter
XAV_08265	COG1725	Transcriptional regulator
XAV_08275	COG0386	Belongs to the glutathione peroxidase family
XAV_08290	COG2900	Belongs to the SlyX family
XAV_08315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XAV_08330	COG0646	methionine synthase
XAV_08330	COG1410	methionine synthase
XAV_08335	COG2226	methyltransferase
XAV_08340	COG1960	acyl-CoA dehydrogenase activity
XAV_08355	COG0557	exoribonuclease II activity
XAV_08375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XAV_08385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XAV_08395	COG0704	Plays a role in the regulation of phosphate uptake
XAV_08400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XAV_08405	COG0581	inorganic phosphate transmembrane transporter activity
XAV_08410	COG0573	inorganic phosphate transmembrane transporter activity
XAV_08415	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XAV_08440	COG0659	secondary active sulfate transmembrane transporter activity
XAV_08445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XAV_08455	COG1024	Enoyl-CoA hydratase
XAV_08465	COG0494	nUDIX hydrolase
XAV_08510	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XAV_08510	COG0116	Belongs to the methyltransferase superfamily
XAV_08515	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XAV_08535	COG0667	Aldo Keto reductase
XAV_08545	COG2925	Exonuclease
XAV_08550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XAV_08555	COG3844	kynureninase activity
XAV_08565	COG0662	Cupin 2, conserved barrel domain protein
XAV_08570	COG0288	reversible hydration of carbon dioxide
XAV_08655	COG0017	Asparaginyl-tRNA synthetase
XAV_08660	COG0316	Belongs to the HesB IscA family
XAV_08665	COG0360	Binds together with S18 to 16S ribosomal RNA
XAV_08670	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XAV_08675	COG0359	binds to the 23S rRNA
XAV_08685	COG3115	cell septum assembly
XAV_08695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XAV_08700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XAV_08705	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XAV_08720	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XAV_08770	COG3039	Transposase
XAV_08785	COG2951	lytic endotransglycosylase activity
XAV_08800	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XAV_08810	COG2986	histidine ammonia-lyase
XAV_08815	COG1228	amidohydrolase
XAV_08855	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
XAV_08860	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XAV_08865	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XAV_08870	COG1605	Chorismate mutase
XAV_08870	COG0077	Prephenate dehydratase
XAV_08875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XAV_08900	COG0583	DNA-binding transcription factor activity
XAV_08915	COG0840	transmembrane signaling receptor activity
XAV_08935	COG2205	protein histidine kinase activity
XAV_08935	COG0784	Response regulator, receiver
XAV_08935	COG5002	protein histidine kinase activity
XAV_08940	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XAV_08945	COG0784	Response regulator, receiver
XAV_08945	COG4191	Histidine kinase
XAV_08960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XAV_08970	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XAV_08980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XAV_09045	COG2244	polysaccharide biosynthetic process
XAV_09070	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
XAV_09075	COG2226	methyltransferase
XAV_09085	COG0438	transferase activity, transferring glycosyl groups
XAV_09100	COG1136	(ABC) transporter
XAV_09105	COG1132	(ABC) transporter
XAV_09110	COG0477	Major facilitator Superfamily
XAV_09115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XAV_09130	COG1253	flavin adenine dinucleotide binding
XAV_09165	COG0504	CTP synthase activity
XAV_09180	COG0148	phosphopyruvate hydratase activity
XAV_09185	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XAV_09200	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XAV_09205	COG0585	pseudouridine synthase activity
XAV_09210	COG2840	Smr protein MutS2
XAV_09215	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XAV_09220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XAV_09225	COG1238	metal cluster binding
XAV_09240	COG1534	Rna-binding protein
XAV_09245	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XAV_09255	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XAV_09260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XAV_09270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XAV_09275	COG1546	Belongs to the CinA family
XAV_09285	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XAV_09290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XAV_09295	COG2137	regulation of response to DNA damage stimulus
XAV_09300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XAV_09305	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XAV_09330	COG4191	Histidine kinase
XAV_09330	COG0784	Response regulator, receiver
XAV_09335	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XAV_09340	COG1194	a g-specific adenine glycosylase
XAV_09345	COG0552	protein localization to endoplasmic reticulum
XAV_09355	COG3938	Belongs to the proline racemase family
XAV_09360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAV_09375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XAV_09385	COG0006	proline dipeptidase activity
XAV_09400	COG0531	amino acid
XAV_09500	COG3039	Transposase
XAV_09520	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XAV_09525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XAV_09530	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XAV_09555	COG1472	Belongs to the glycosyl hydrolase 3 family
XAV_09570	COG5001	Diguanylate cyclase
XAV_09570	COG4251	negative regulation of phosphorylation
XAV_09570	COG2203	Gaf domain
XAV_09570	COG3706	GGDEF domain
XAV_09575	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAV_09580	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XAV_09590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XAV_09595	COG0671	phosphoesterase, PA-phosphatase related
XAV_09610	COG0697	spore germination
XAV_09615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XAV_09620	COG0167	dihydroorotate dehydrogenase activity
XAV_09635	COG1012	belongs to the aldehyde dehydrogenase family
XAV_09680	COG2948	multi-organism process
XAV_09700	COG3702	type iv secretory pathway
XAV_09740	COG3039	Transposase
XAV_09750	COG0784	Response regulator, receiver
XAV_09750	COG5002	protein histidine kinase activity
XAV_09750	COG2205	protein histidine kinase activity
XAV_09755	COG2733	membrane
XAV_09770	COG2223	nitrite transmembrane transporter activity
XAV_09775	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XAV_09780	COG0243	molybdopterin cofactor binding
XAV_09795	COG2703	oxygen carrier activity
XAV_09805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAV_09810	COG0174	glutamine synthetase
XAV_09815	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XAV_09840	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XAV_09860	COG3842	ATPase activity
XAV_09865	COG1176	ABC-type spermidine putrescine transport system, permease component I
XAV_09870	COG1177	transmembrane transport
XAV_09875	COG1012	belongs to the aldehyde dehydrogenase family
XAV_09890	COG4535	Mg2 and Co2 transporter CorC
XAV_09900	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XAV_09910	COG1702	phosphate starvation-inducible protein PhoH
XAV_09915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XAV_09930	COG0741	lytic transglycosylase activity
XAV_09935	COG0723	plastoquinol--plastocyanin reductase activity
XAV_09940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XAV_09945	COG2857	Cytochrome c1
XAV_09950	COG0625	glutathione transferase activity
XAV_09955	COG2969	positive regulation of protein catabolic process
XAV_09980	COG2094	Belongs to the DNA glycosylase MPG family
XAV_09990	COG0835	chemotaxis
XAV_10010	COG3039	Transposase
XAV_10030	COG3039	Transposase
XAV_10195	COG3279	Response regulator of the LytR AlgR family
XAV_10215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAV_10235	COG4566	intracellular signal transduction
XAV_10270	COG2154	pterin-4-alpha-carbinolamine dehydratase
XAV_10285	COG3064	Membrane
XAV_10295	COG1530	ribonuclease E activity
XAV_10325	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XAV_10355	COG1858	cytochrome C peroxidase
XAV_10385	COG0515	serine threonine protein kinase
XAV_10390	COG0631	protein serine/threonine phosphatase activity
XAV_10425	COG3501	Rhs element vgr protein
XAV_10550	COG2336	PFAM SpoVT AbrB
XAV_10570	COG2003	Belongs to the UPF0758 family
XAV_10610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XAV_10615	COG0322	excinuclease ABC activity
XAV_10625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XAV_10630	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XAV_10635	COG1663	tetraacyldisaccharide 4'-kinase activity
XAV_10640	COG1132	(ABC) transporter
XAV_10650	COG0811	peptide transport
XAV_10665	COG1136	(ABC) transporter
XAV_10670	COG4591	ABC-type transport system involved in lipoprotein release permease component
XAV_10680	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XAV_10685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XAV_10700	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XAV_10715	COG0354	folic acid binding
XAV_10725	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XAV_10730	COG0837	glucose binding
XAV_10735	COG0363	glucosamine-6-phosphate deaminase activity
XAV_10740	COG0129	dihydroxy-acid dehydratase activity
XAV_10745	COG0800	Aldolase
XAV_10835	COG2183	response to ionizing radiation
XAV_10845	COG0723	plastoquinol--plastocyanin reductase activity
XAV_10845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAV_10860	COG3243	poly(R)-hydroxyalkanoic acid synthase
XAV_10870	COG1183	phosphatidylcholine synthase activity
XAV_10875	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_10890	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XAV_10900	COG0668	transmembrane transport
XAV_10905	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XAV_10920	COG1914	H( )-stimulated, divalent metal cation uptake system
XAV_10970	COG0633	Ferredoxin
XAV_10990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XAV_10995	COG3002	Belongs to the UPF0753 family
XAV_11005	COG0519	Catalyzes the synthesis of GMP from XMP
XAV_11005	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XAV_11015	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XAV_11030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XAV_11045	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XAV_11055	COG0776	regulation of translation
XAV_11060	COG0539	negative regulation of cytoplasmic translation
XAV_11065	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XAV_11080	COG2957	Belongs to the agmatine deiminase family
XAV_11085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XAV_11110	COG0395	ABC-type sugar transport system, permease component
XAV_11115	COG1175	transmembrane transport
XAV_11145	COG2350	Protein conserved in bacteria
XAV_11150	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XAV_11155	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XAV_11160	COG1187	pseudouridine synthase activity
XAV_11185	COG0436	Aminotransferase
XAV_11190	COG4133	protoheme IX ABC transporter activity
XAV_11210	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XAV_11215	COG1138	Cytochrome C-type biogenesis protein
XAV_11235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XAV_11240	COG1278	Cold shock
XAV_11245	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XAV_11250	COG4988	ABC transporter
XAV_11285	COG3609	addiction module antidote protein, CC2985 family
XAV_11350	COG3039	Transposase
XAV_11355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XAV_11375	COG0165	Argininosuccinate lyase
XAV_11380	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XAV_11390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XAV_11395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XAV_11405	COG0137	argininosuccinate synthase activity
XAV_11410	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XAV_11420	COG0215	cysteine-tRNA ligase activity
XAV_11430	COG2166	iron-sulfur cluster assembly
XAV_11445	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XAV_11450	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XAV_11490	COG4677	pectinesterase activity
XAV_11510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XAV_11515	COG0402	S-adenosylhomocysteine deaminase activity
XAV_11525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XAV_11530	COG1509	lysine 2,3-aminomutase activity
XAV_11535	COG3300	MHYT domain
XAV_11535	COG5001	Diguanylate cyclase
XAV_11550	COG0483	inositol monophosphate 1-phosphatase activity
XAV_11555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XAV_11575	COG0513	Belongs to the DEAD box helicase family
XAV_11580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XAV_11585	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XAV_11595	COG0625	glutathione transferase activity
XAV_11605	COG4681	YaeQ
XAV_11610	COG2081	HI0933 family
XAV_11620	COG0501	Belongs to the peptidase M48B family
XAV_11625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XAV_11630	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_11655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XAV_11660	COG0860	N-Acetylmuramoyl-L-alanine amidase
XAV_11665	COG0802	atpase or kinase
XAV_11670	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XAV_11670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XAV_11680	COG1570	exodeoxyribonuclease VII activity
XAV_11690	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XAV_11730	COG3039	Transposase
XAV_11760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XAV_11760	COG1648	precorrin-2 dehydrogenase activity
XAV_11790	COG0303	'Molybdopterin
XAV_11810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XAV_11815	COG0303	'Molybdopterin
XAV_11820	COG1160	GTP binding
XAV_11825	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAV_11835	COG1426	Protein conserved in bacteria
XAV_11845	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XAV_11860	COG1250	3-hydroxyacyl-CoA dehydrogenase
XAV_11860	COG1024	Enoyl-CoA hydratase
XAV_11865	COG0183	Belongs to the thiolase family
XAV_11870	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XAV_11875	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XAV_11885	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XAV_11895	COG1674	ftsk spoiiie
XAV_11900	COG0492	ferredoxin-NADP+ reductase activity
XAV_11920	COG0542	response to heat
XAV_11935	COG0482	sulfurtransferase activity
XAV_11940	COG2915	High frequency lysogenization protein hflD homolog
XAV_11975	COG5002	protein histidine kinase activity
XAV_12000	COG0835	chemotaxis
XAV_12000	COG0784	Response regulator, receiver
XAV_12010	COG1558	bacterial-type flagellum-dependent cell motility
XAV_12015	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XAV_12025	COG4787	bacterial-type flagellum-dependent cell motility
XAV_12035	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XAV_12040	COG1706	bacterial-type flagellum-dependent cell motility
XAV_12045	COG3951	Flagellar rod assembly protein muramidase FlgJ
XAV_12045	COG1705	Flagellar rod assembly protein muramidase FlgJ
XAV_12055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XAV_12060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XAV_12065	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
XAV_12095	COG2201	protein-glutamate methylesterase activity
XAV_12115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XAV_12120	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_12125	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_12155	COG1677	Flagellar hook-basal body complex protein FliE
XAV_12225	COG1684	flagellar biosynthetic protein fliR
XAV_12230	COG3300	MHYT domain
XAV_12230	COG5001	Diguanylate cyclase
XAV_12235	COG3300	MHYT domain
XAV_12235	COG5001	Diguanylate cyclase
XAV_12280	COG0784	Response regulator, receiver
XAV_12280	COG0643	Histidine kinase
XAV_12280	COG2198	Histidine kinase
XAV_12305	COG3039	Transposase
XAV_12330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XAV_12340	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XAV_12345	COG1360	Flagellar Motor Protein
XAV_12350	COG1192	Involved in chromosome partitioning
XAV_12365	COG0745	RESPONSE REGULATOR receiver
XAV_12375	COG0840	transmembrane signaling receptor activity
XAV_12395	COG0840	transmembrane signaling receptor activity
XAV_12405	COG0840	transmembrane signaling receptor activity
XAV_12410	COG0840	transmembrane signaling receptor activity
XAV_12420	COG0840	transmembrane signaling receptor activity
XAV_12425	COG0840	transmembrane signaling receptor activity
XAV_12430	COG0840	transmembrane signaling receptor activity
XAV_12435	COG0840	transmembrane signaling receptor activity
XAV_12450	COG0835	chemotaxis
XAV_12460	COG0840	transmembrane signaling receptor activity
XAV_12470	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
XAV_12475	COG2201	protein-glutamate methylesterase activity
XAV_12485	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XAV_12515	COG0318	PFAM AMP-dependent synthetase and ligase
XAV_12520	COG1024	Enoyl-CoA hydratase
XAV_12525	COG2205	protein histidine kinase activity
XAV_12525	COG2198	Histidine kinase
XAV_12525	COG0784	Response regulator, receiver
XAV_12530	COG2198	Histidine kinase
XAV_12530	COG2205	protein histidine kinase activity
XAV_12530	COG0784	Response regulator, receiver
XAV_12540	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XAV_12570	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XAV_12580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XAV_12585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XAV_12600	COG0505	Belongs to the CarA family
XAV_12605	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XAV_12660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XAV_12680	COG0277	FAD linked oxidase domain protein
XAV_12685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XAV_12695	COG0531	amino acid
XAV_12700	COG0531	amino acid
XAV_12705	COG0235	Class ii aldolase
XAV_12710	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XAV_12715	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XAV_12795	COG0140	phosphoribosyl-ATP diphosphatase activity
XAV_12795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XAV_12800	COG0107	imidazoleglycerol-phosphate synthase activity
XAV_12805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XAV_12810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XAV_12815	COG0131	Imidazoleglycerol-phosphate dehydratase
XAV_12815	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XAV_12820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XAV_12825	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XAV_12830	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XAV_12840	COG0124	histidyl-tRNA synthetase
XAV_12850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XAV_12880	COG0083	homoserine kinase activity
XAV_12915	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XAV_12925	COG1862	Preprotein translocase
XAV_12930	COG0343	queuine tRNA-ribosyltransferase activity
XAV_12970	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XAV_12975	COG3291	Pkd domain containing protein
XAV_12985	COG0405	Gamma-glutamyltransferase
XAV_12990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XAV_13000	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XAV_13005	COG0742	ribosomal rna small subunit methyltransferase
XAV_13010	COG0326	Molecular chaperone. Has ATPase activity
XAV_13030	COG3039	Transposase
XAV_13055	COG2902	Dehydrogenase
XAV_13065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAV_13070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XAV_13075	COG1609	Transcriptional regulator
XAV_13080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XAV_13080	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XAV_13085	COG1105	Belongs to the carbohydrate kinase PfkB family
XAV_13090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XAV_13090	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XAV_13120	COG1469	GTP cyclohydrolase I activity
XAV_13125	COG0860	N-Acetylmuramoyl-L-alanine amidase
XAV_13135	COG3039	Transposase
XAV_13145	COG1070	Carbohydrate kinase
XAV_13155	COG1501	Belongs to the glycosyl hydrolase 31 family
XAV_13210	COG0800	Aldolase
XAV_13215	COG4948	Mandelate Racemase Muconate Lactonizing
XAV_13225	COG3734	2-keto-3-deoxy-galactonokinase
XAV_13230	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XAV_13240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XAV_13255	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XAV_13260	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XAV_13275	COG0351	phosphomethylpyrimidine kinase
XAV_13300	COG0583	DNA-binding transcription factor activity
XAV_13305	COG1741	Belongs to the pirin family
XAV_13345	COG3040	lipid binding
XAV_13355	COG1960	acyl-CoA dehydrogenase activity
XAV_13365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XAV_13385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XAV_13420	COG0438	transferase activity, transferring glycosyl groups
XAV_13430	COG0438	transferase activity, transferring glycosyl groups
XAV_13435	COG0438	transferase activity, transferring glycosyl groups
XAV_13485	COG0072	phenylalanine-tRNA ligase activity
XAV_13485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XAV_13490	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XAV_13505	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XAV_13510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XAV_13540	COG2801	Transposase and inactivated derivatives
XAV_13565	COG0556	nucleotide-excision repair
XAV_13610	COG3275	phosphorelay sensor kinase activity
XAV_13615	COG1611	Belongs to the LOG family
XAV_13625	COG2095	MarC family integral membrane protein
XAV_13635	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XAV_13670	COG1185	polyribonucleotide nucleotidyltransferase activity
XAV_13675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XAV_13680	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XAV_13685	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XAV_13690	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XAV_13695	COG0195	Participates in both transcription termination and antitermination
XAV_13700	COG0779	Required for maturation of 30S ribosomal subunits
XAV_13710	COG1007	ATP synthesis coupled electron transport
XAV_13735	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAV_13740	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XAV_13745	COG1034	ATP synthesis coupled electron transport
XAV_13750	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XAV_13755	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XAV_13760	COG0649	NAD binding
XAV_13765	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAV_13770	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAV_13775	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAV_13790	COG0149	triose-phosphate isomerase activity
XAV_13795	COG4221	oxidoreductase activity
XAV_13825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XAV_13830	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XAV_13835	COG0159	tryptophan synthase activity
XAV_13845	COG0133	tryptophan synthase activity
XAV_13855	COG0135	phosphoribosylanthranilate isomerase activity
XAV_13860	COG0101	tRNA pseudouridine synthase activity
XAV_13875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XAV_13880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XAV_13885	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XAV_13890	COG2890	protein-(glutamine-N5) methyltransferase activity
XAV_13900	COG0688	phosphatidylethanolamine metabolic process
XAV_13910	COG0433	COG0433 Predicted ATPase
XAV_13930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XAV_13955	COG0717	Belongs to the dCTP deaminase family
XAV_13960	COG0489	protein tyrosine kinase activity
XAV_13980	COG3590	peptidase
XAV_13985	COG3590	peptidase
XAV_14005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XAV_14010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAV_14015	COG2311	Membrane
XAV_14020	COG1047	Peptidyl-prolyl cis-trans
XAV_14025	COG0791	NLP P60 protein
XAV_14030	COG0791	NLP P60 protein
XAV_14050	COG1301	dicarboxylic acid transport
XAV_14055	COG1785	Belongs to the alkaline phosphatase family
XAV_14060	COG0037	tRNA processing
XAV_14065	COG1722	exodeoxyribonuclease VII activity
XAV_14070	COG0142	geranyltranstransferase activity
XAV_14085	COG0312	modulator of DNA gyrase
XAV_14090	COG3028	Belongs to the UPF0307 family
XAV_14095	COG0312	modulator of DNA gyrase
XAV_14105	COG3164	Protein of unknown function
XAV_14110	COG1530	ribonuclease E activity
XAV_14115	COG0424	maF-like protein
XAV_14120	COG2968	Membrane
XAV_14135	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XAV_14155	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XAV_14170	COG0495	leucyl-tRNA aminoacylation
XAV_14180	COG3118	belongs to the thioredoxin family
XAV_14205	COG2155	Conserved Protein
XAV_14260	COG1132	(ABC) transporter
XAV_14295	COG5000	phosphorelay sensor kinase activity
XAV_14295	COG5002	protein histidine kinase activity
XAV_14300	COG0475	glutathione-regulated potassium exporter activity
XAV_14310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XAV_14345	COG1187	pseudouridine synthase activity
XAV_14350	COG5002	protein histidine kinase activity
XAV_14350	COG5001	Diguanylate cyclase
XAV_14475	COG0583	DNA-binding transcription factor activity
XAV_14530	COG0735	belongs to the Fur family
XAV_14535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XAV_14560	COG4452	Inner membrane protein CreD
XAV_14575	COG0745	RESPONSE REGULATOR receiver
XAV_14580	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XAV_14590	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XAV_14600	COG2198	Histidine kinase
XAV_14600	COG0643	Histidine kinase
XAV_14605	COG0840	transmembrane signaling receptor activity
XAV_14610	COG0835	chemotaxis
XAV_14620	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XAV_14625	COG2201	protein-glutamate methylesterase activity
XAV_14635	COG3590	peptidase
XAV_14645	COG0588	phosphoglycerate mutase activity
XAV_14650	COG1515	deoxyribonuclease V activity
XAV_14670	COG1741	Belongs to the pirin family
XAV_14675	COG1966	Carbon starvation protein
XAV_14680	COG2879	small protein
XAV_14715	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
XAV_14720	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XAV_14725	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XAV_14730	COG2080	2 iron, 2 sulfur cluster binding
XAV_14740	COG2203	Gaf domain
XAV_14740	COG3706	GGDEF domain
XAV_14740	COG4251	negative regulation of phosphorylation
XAV_14740	COG5001	Diguanylate cyclase
XAV_14745	COG0629	single-stranded DNA binding
XAV_14750	COG0142	geranyltranstransferase activity
XAV_14760	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XAV_14775	COG0527	aspartate kinase activity
XAV_14785	COG0384	phenazine biosynthesis protein PhzF
XAV_14795	COG1764	response to oxidative stress
XAV_14800	COG0540	Belongs to the ATCase OTCase family
XAV_14805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XAV_14810	COG1678	Uncharacterized ACR, COG1678
XAV_14815	COG0519	Catalyzes the synthesis of GMP from XMP
XAV_14840	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XAV_14895	COG1959	2 iron, 2 sulfur cluster binding
XAV_14900	COG0719	Fe-S assembly protein
XAV_14905	COG0396	ATPase activity
XAV_14910	COG0719	Fe-S assembly protein
XAV_14915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XAV_14920	COG0456	acetyltransferase
XAV_14925	COG2146	nitrite reductase [NAD(P)H] activity
XAV_14930	COG4774	siderophore transport
XAV_14935	COG3128	pkhd-type hydroxylase
XAV_14960	COG1555	photosystem II stabilization
XAV_14965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XAV_14975	COG3178	'Phosphotransferase
XAV_14980	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XAV_14990	COG0628	permease
XAV_15000	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XAV_15015	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XAV_15040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XAV_15045	COG0271	Belongs to the BolA IbaG family
XAV_15055	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XAV_15065	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XAV_15070	COG1137	ATPase activity
XAV_15085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XAV_15090	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XAV_15095	COG1660	Displays ATPase and GTPase activities
XAV_15130	COG4772	TonB-dependent receptor
XAV_15140	COG4264	IucA IucC family
XAV_15145	COG2814	Major facilitator Superfamily
XAV_15155	COG0019	diaminopimelate decarboxylase activity
XAV_15180	COG0542	response to heat
XAV_15280	COG1877	trehalose-phosphatase activity
XAV_15285	COG3387	PFAM Glycoside hydrolase 15-related
XAV_15305	COG2201	protein-glutamate methylesterase activity
XAV_15380	COG2197	response regulator
XAV_15385	COG4585	Histidine kinase
XAV_15395	COG0850	regulation of cytokinetic process
XAV_15400	COG2894	cell division
XAV_15405	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XAV_15415	COG0642	Histidine kinase
XAV_15420	COG0745	RESPONSE REGULATOR receiver
XAV_15435	COG2194	sulfuric ester hydrolase activity
XAV_15450	COG2814	Major facilitator Superfamily
XAV_15475	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XAV_15475	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XAV_15490	COG0656	L-ascorbic acid biosynthetic process
XAV_15495	COG0753	catalase activity
XAV_15525	COG2207	Transcriptional regulator
XAV_15525	COG1917	Cupin 2, conserved barrel domain protein
XAV_15540	COG1506	peptidase
XAV_15540	COG0823	Involved in the tonB-independent uptake of proteins
XAV_15550	COG1297	OPT oligopeptide transporter protein
XAV_15570	COG0587	DNA-directed DNA polymerase activity
XAV_15585	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XAV_15620	COG2080	2 iron, 2 sulfur cluster binding
XAV_15625	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XAV_15630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XAV_15675	COG0492	ferredoxin-NADP+ reductase activity
XAV_15685	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_15755	COG0732	type I restriction modification DNA specificity domain
XAV_15820	COG2814	Major facilitator Superfamily
XAV_15905	COG0314	molybdopterin synthase activity
XAV_15910	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XAV_15915	COG0315	cyclic pyranopterin monophosphate synthase activity
XAV_15920	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XAV_15925	COG1234	tRNA 3'-trailer cleavage
XAV_15930	COG3642	lipopolysaccharide core region biosynthetic process
XAV_15935	COG0859	PFAM glycosyl transferase family 9
XAV_15950	COG0631	protein serine/threonine phosphatase activity
XAV_15955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XAV_15960	COG0328	RNA-DNA hybrid ribonuclease activity
XAV_15970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XAV_15980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XAV_16010	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XAV_16020	COG0544	peptidyl-prolyl cis-trans isomerase activity
XAV_16080	COG0473	3-isopropylmalate dehydrogenase activity
XAV_16095	COG4783	chaperone-mediated protein folding
XAV_16110	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XAV_16120	COG0438	transferase activity, transferring glycosyl groups
XAV_16125	COG0671	phosphoesterase, PA-phosphatase related
XAV_16130	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAV_16145	COG2833	Protein of unknown function (DUF455)
XAV_16165	COG0285	dihydrofolate synthase activity
XAV_16185	COG0406	alpha-ribazole phosphatase activity
XAV_16195	COG3039	Transposase
XAV_16225	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XAV_16230	COG4208	sulfate ABC transporter
XAV_16235	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XAV_16240	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XAV_16245	COG0156	8-amino-7-oxononanoate synthase activity
XAV_16265	COG2885	chlorophyll binding
XAV_16270	COG0604	alcohol dehydrogenase
XAV_16275	COG1902	pentaerythritol trinitrate reductase activity
XAV_16275	COG0446	pyridine nucleotide-disulphide oxidoreductase
XAV_16300	COG0039	L-malate dehydrogenase activity
XAV_16305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XAV_16335	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XAV_16345	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XAV_16350	COG0203	ribosomal protein L17
XAV_16375	COG0201	protein transport
XAV_16380	COG0200	Binds to the 23S rRNA
XAV_16385	COG1841	ribosomal large subunit assembly
XAV_16395	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XAV_16400	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XAV_16415	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XAV_16420	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XAV_16430	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XAV_16435	COG0255	Belongs to the universal ribosomal protein uL29 family
XAV_16445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XAV_16455	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XAV_16460	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XAV_16465	COG0089	rRNA binding
XAV_16470	COG0088	Forms part of the polypeptide exit tunnel
XAV_16475	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XAV_16480	COG0051	transcription antitermination factor activity, RNA binding
XAV_16495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XAV_16500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XAV_16505	COG0049	tRNA binding
XAV_16510	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XAV_16515	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XAV_16520	COG0085	RNA polymerase activity
XAV_16530	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XAV_16535	COG0081	regulation of translation
XAV_16540	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XAV_16545	COG0250	Participates in transcription elongation, termination and antitermination
XAV_16550	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XAV_16560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XAV_16580	COG0012	GTP binding
XAV_16585	COG0193	aminoacyl-tRNA hydrolase activity
XAV_16590	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XAV_16595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XAV_16605	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XAV_16610	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XAV_16620	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XAV_16625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XAV_16640	COG0521	Mo-molybdopterin cofactor biosynthetic process
XAV_16655	COG1254	Belongs to the acylphosphatase family
XAV_16660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XAV_16665	COG1295	ribonuclease BN
XAV_16690	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XAV_16695	COG1404	Belongs to the peptidase S8 family
XAV_16700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XAV_16765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XAV_16765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XAV_16785	COG2890	protein-(glutamine-N5) methyltransferase activity
XAV_16795	COG3634	alkyl hydroperoxide reductase activity
XAV_16800	COG0583	DNA-binding transcription factor activity
XAV_16805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XAV_16810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XAV_16820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XAV_16830	COG2197	response regulator
XAV_16865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XAV_16870	COG0697	spore germination
XAV_16900	COG3386	PFAM SMP-30 Gluconolaconase
XAV_16920	COG1024	Enoyl-CoA hydratase
XAV_16930	COG0318	PFAM AMP-dependent synthetase and ligase
XAV_16935	COG0583	DNA-binding transcription factor activity
XAV_16940	COG3384	dioxygenase
XAV_16980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XAV_16985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XAV_16995	COG2096	Adenosyltransferase
XAV_17000	COG0123	including yeast histone deacetylase and acetoin utilization protein
XAV_17005	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XAV_17010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XAV_17015	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XAV_17020	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XAV_17025	COG2967	ApaG domain
XAV_17030	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XAV_17050	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XAV_17055	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XAV_17065	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
XAV_17075	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XAV_17085	COG0642	Histidine kinase
XAV_17100	COG4181	ATPase activity
XAV_17110	COG2175	clavaminate synthase activity
XAV_17120	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XAV_17125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XAV_17150	COG0667	Aldo Keto reductase
XAV_17155	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XAV_17160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XAV_17205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XAV_17210	COG4106	trans-aconitate 2-methyltransferase activity
XAV_17220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XAV_17255	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XAV_17265	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XAV_17270	COG2226	methyltransferase
XAV_17300	COG0366	Alpha amylase catalytic
XAV_17325	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XAV_17335	COG0494	nUDIX hydrolase
XAV_17340	COG0653	protein targeting
XAV_17345	COG0739	heme binding
XAV_17355	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XAV_17370	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XAV_17375	COG1181	Belongs to the D-alanine--D-alanine ligase family
XAV_17380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XAV_17385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XAV_17395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XAV_17400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XAV_17405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XAV_17415	COG3116	cell division
XAV_17420	COG0275	rRNA processing
XAV_17450	COG0792	nuclease activity
XAV_17455	COG1988	membrane-bound metal-dependent
XAV_17460	COG0277	FAD linked oxidase domain protein
XAV_17470	COG0745	RESPONSE REGULATOR receiver
XAV_17475	COG2205	protein histidine kinase activity
XAV_17485	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XAV_17490	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XAV_17525	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XAV_17530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XAV_17535	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XAV_17555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XAV_17555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XAV_17565	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XAV_17570	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XAV_17595	COG0488	(ABC) transporter
XAV_17610	COG3791	Glutathione-dependent formaldehyde-activating
XAV_17660	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XAV_17675	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XAV_17685	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
XAV_17690	COG0174	glutamine synthetase
XAV_17715	COG0745	RESPONSE REGULATOR receiver
XAV_17720	COG2205	protein histidine kinase activity
XAV_17790	COG0617	tRNA 3'-terminal CCA addition
XAV_17805	COG1649	PFAM Uncharacterised BCR, COG1649
XAV_17805	COG0726	polysaccharide deacetylase
XAV_17810	COG1215	transferase activity, transferring glycosyl groups
XAV_17825	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XAV_17830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XAV_17835	COG1609	Transcriptional regulator
XAV_17845	COG2188	Transcriptional regulator
XAV_17920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XAV_17925	COG4191	Histidine kinase
XAV_17930	COG0784	Response regulator, receiver
XAV_17935	COG4251	negative regulation of phosphorylation
XAV_17940	COG2823	Periplasmic or secreted lipoprotein
XAV_17945	COG0673	inositol 2-dehydrogenase activity
XAV_17950	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XAV_17995	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XAV_18000	COG0321	lipoyl(octanoyl) transferase activity
XAV_18005	COG2921	Belongs to the UPF0250 family
XAV_18015	COG1686	Belongs to the peptidase S11 family
XAV_18020	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XAV_18025	COG2951	lytic endotransglycosylase activity
XAV_18035	COG0772	Belongs to the SEDS family
XAV_18050	COG1792	Involved in formation and maintenance of cell shape
XAV_18055	COG1077	Cell shape determining protein MreB Mrl
XAV_18060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XAV_18075	COG3039	Transposase
XAV_18090	COG0028	Belongs to the TPP enzyme family
XAV_18090	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
XAV_18100	COG1213	nucleotidyl transferase
XAV_18105	COG0367	asparagine synthase
XAV_18115	COG0730	response to heat
XAV_18150	COG0308	aminopeptidase N
XAV_18155	COG5001	Diguanylate cyclase
XAV_18155	COG3300	MHYT domain
XAV_18190	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XAV_18195	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XAV_18200	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XAV_18210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XAV_18220	COG2832	Protein of unknown function (DUF454)
XAV_18235	COG1505	serine-type exopeptidase activity
XAV_18265	COG0181	hydroxymethylbilane synthase activity
XAV_18275	COG3275	phosphorelay sensor kinase activity
XAV_18285	COG2943	transferase activity, transferring hexosyl groups
XAV_18310	COG0659	secondary active sulfate transmembrane transporter activity
XAV_18315	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAV_18315	COG5297	Belongs to the glycosyl hydrolase family 6
XAV_18320	COG0840	transmembrane signaling receptor activity
XAV_18375	COG0598	Magnesium transport protein CorA
XAV_18385	COG1113	amino acid transport
XAV_18400	COG5297	Belongs to the glycosyl hydrolase family 6
XAV_18405	COG3039	Transposase
XAV_18410	COG4305	rare lipoprotein A
XAV_18415	COG0697	spore germination
XAV_18495	COG4221	oxidoreductase activity
XAV_18525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAV_18525	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
XAV_18590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XAV_18595	COG1490	D-aminoacyl-tRNA deacylase activity
XAV_18600	COG1560	Kdo2-lipid A biosynthetic process
XAV_18645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XAV_18645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XAV_18650	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XAV_18655	COG0242	peptide deformylase activity
XAV_18660	COG1652	LysM domain
XAV_18665	COG0758	DNA mediated transformation
XAV_18690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XAV_18690	COG1754	DNA topoisomerase type I activity
XAV_18695	COG0009	L-threonylcarbamoyladenylate synthase
XAV_18710	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_18720	COG0616	signal peptide processing
XAV_18725	COG0534	Mate efflux family protein
XAV_18745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XAV_18765	COG1252	NADH dehydrogenase
XAV_18775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XAV_18780	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XAV_18785	COG2201	protein-glutamate methylesterase activity
XAV_18790	COG2177	Part of the ABC transporter FtsEX involved in
XAV_18795	COG2884	Cell division ATP-binding protein ftsE
XAV_18800	COG0513	Belongs to the DEAD box helicase family
XAV_18805	COG3118	belongs to the thioredoxin family
XAV_18810	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XAV_18855	COG1518	maintenance of DNA repeat elements
XAV_18860	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
XAV_18875	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XAV_18875	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XAV_18880	COG1473	amidohydrolase
XAV_18885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAV_18890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XAV_18900	COG5383	Protein conserved in bacteria
XAV_18945	COG3023	N-Acetylmuramoyl-L-alanine amidase
XAV_18955	COG4948	Mandelate Racemase Muconate Lactonizing
XAV_18970	COG0531	amino acid
XAV_18985	COG4682	membrane
XAV_18990	COG2133	pyrroloquinoline quinone binding
XAV_19000	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XAV_19005	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XAV_19015	COG1610	YqeY-like protein
XAV_19025	COG1295	ribonuclease BN
XAV_19030	COG0358	DNA primase activity
XAV_19045	COG0109	protoheme IX farnesyltransferase activity
XAV_19075	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XAV_19090	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XAV_19140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XAV_19145	COG0739	heme binding
XAV_19150	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XAV_19160	COG2223	nitrite transmembrane transporter activity
XAV_19165	COG0708	Exodeoxyribonuclease III
XAV_19170	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XAV_19180	COG1192	Involved in chromosome partitioning
XAV_19185	COG1475	DNA binding
XAV_19205	COG0463	Glycosyl transferase, family 2
XAV_19225	COG0756	dUTP diphosphatase activity
XAV_19230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XAV_19235	COG2003	Belongs to the UPF0758 family
XAV_19240	COG0018	arginyl-trna synthetase
XAV_19255	COG4221	oxidoreductase activity
XAV_19260	COG2755	lipolytic protein G-D-S-L family
XAV_19260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XAV_19275	COG1166	arginine decarboxylase activity
XAV_19280	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XAV_19300	COG3291	Pkd domain containing protein
XAV_19300	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XAV_19315	COG0606	chelatase, subunit chli
XAV_19330	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XAV_19385	COG1090	epimerase
XAV_19395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XAV_19420	COG1011	Hydrolase
XAV_19425	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XAV_19440	COG0753	catalase activity
XAV_19490	COG0180	Tryptophanyl-tRNA synthetase
XAV_19495	COG3237	CsbD-like
XAV_19535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XAV_19550	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XAV_19555	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XAV_19555	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XAV_19580	COG2205	protein histidine kinase activity
XAV_19585	COG0745	RESPONSE REGULATOR receiver
XAV_19595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XAV_19615	COG1199	ATP-dependent helicase activity
XAV_19630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XAV_19640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XAV_19720	COG4555	ABC transporter
XAV_19730	COG1476	TRANSCRIPTIONal
XAV_19745	COG1230	cation diffusion facilitator family transporter
XAV_19750	COG0543	2 iron, 2 sulfur cluster binding
XAV_19750	COG0633	Ferredoxin
XAV_19755	COG1131	(ABC) transporter
XAV_19760	COG0842	Transport permease protein
XAV_19805	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XAV_19810	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XAV_19825	COG0045	succinate-CoA ligase (ADP-forming) activity
XAV_19825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XAV_19825	COG1042	CoA-binding domain protein
XAV_19835	COG2239	Acts as a magnesium transporter
XAV_19850	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XAV_19855	COG3387	PFAM Glycoside hydrolase 15-related
XAV_19870	COG3100	YcgL domain-containing protein
XAV_19875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XAV_19885	COG0463	Glycosyl transferase, family 2
XAV_19895	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_19925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XAV_19940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XAV_19980	COG0408	coproporphyrinogen oxidase activity
XAV_19990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XAV_19990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XAV_20020	COG0154	amidase activity
XAV_20040	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XAV_20060	COG2072	flavoprotein involved in K transport
XAV_20065	COG2351	hydroxyisourate hydrolase activity
XAV_20070	COG4807	Protein conserved in bacteria
XAV_20080	COG1643	Atp-dependent helicase
XAV_20090	COG1187	pseudouridine synthase activity
XAV_20105	COG2130	NADP-dependent
XAV_20110	COG0656	L-ascorbic acid biosynthetic process
XAV_20135	COG1764	response to oxidative stress
XAV_20140	COG1846	Transcriptional regulator
XAV_20165	COG0084	hydrolase, TatD family'
XAV_20185	COG2252	PERMEase
XAV_20225	COG3039	Transposase
XAV_20235	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XAV_20245	COG0697	spore germination
XAV_20310	COG1960	acyl-CoA dehydrogenase activity
XAV_20315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XAV_20320	COG4770	biotin carboxylase activity
XAV_20375	COG0339	signal peptide processing
XAV_20400	COG0564	pseudouridine synthase activity
XAV_20410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XAV_20420	COG1181	Belongs to the D-alanine--D-alanine ligase family
XAV_20435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XAV_20445	COG0318	PFAM AMP-dependent synthetase and ligase
XAV_20450	COG0727	PFAM Uncharacterised protein family (UPF0153)
XAV_20455	COG0596	Alpha beta hydrolase
XAV_20470	COG3177	Filamentation induced by cAMP protein fic
XAV_20475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XAV_20490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XAV_20515	COG4191	Histidine kinase
XAV_20520	COG0028	Belongs to the TPP enzyme family
XAV_20535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XAV_20540	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XAV_20545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XAV_20580	COG0183	Belongs to the thiolase family
XAV_20600	COG2032	superoxide dismutase activity
XAV_20605	COG2032	superoxide dismutase activity
XAV_20610	COG2204	response regulator
XAV_20615	COG3852	Histidine kinase
XAV_20620	COG0004	ammonium transporteR
XAV_20625	COG0347	Belongs to the P(II) protein family
XAV_20630	COG0174	glutamine synthetase
XAV_20635	COG1968	undecaprenyl-diphosphatase activity
XAV_20680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAV_20690	COG2062	phosphohistidine phosphatase, SixA
XAV_20695	COG0489	protein tyrosine kinase activity
XAV_20720	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
XAV_20725	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XAV_20740	COG0517	IMP dehydrogenase activity
XAV_20740	COG1125	glycine betaine transport
XAV_20755	COG1119	ATPase activity
XAV_20790	COG1473	amidohydrolase
XAV_20795	COG1752	Esterase of the alpha-beta hydrolase superfamily
XAV_20805	COG1522	sequence-specific DNA binding
XAV_20810	COG3186	Phenylalanine-4-hydroxylase
XAV_20830	COG1028	Short-chain dehydrogenase reductase Sdr
XAV_20840	COG1609	Transcriptional regulator
XAV_20865	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XAV_20875	COG0657	acetylesterase activity
XAV_20875	COG2755	lipolytic protein G-D-S-L family
XAV_20895	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XAV_20900	COG0366	Alpha amylase catalytic
XAV_20905	COG0366	Alpha amylase catalytic
XAV_20945	COG2201	protein-glutamate methylesterase activity
XAV_20970	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XAV_20990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XAV_21050	COG3135	benzoate transporter
XAV_21070	COG0676	glucose-6-phosphate 1-epimerase activity
XAV_21080	COG3012	SEC-C Motif Domain Protein
XAV_21085	COG0730	response to heat
XAV_21110	COG0302	gtp cyclohydrolase
XAV_21140	COG0477	Major facilitator Superfamily
XAV_21250	COG0439	Biotin carboxylase
XAV_21290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XAV_21295	COG1074	ATP-dependent DNA helicase activity
XAV_21300	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XAV_21305	COG1116	anion transmembrane transporter activity
XAV_21330	COG1136	(ABC) transporter
XAV_21345	COG1127	ABC transporter
XAV_21350	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XAV_21355	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XAV_21370	COG2853	Lipoprotein
XAV_21390	COG0386	Belongs to the glutathione peroxidase family
XAV_21400	COG1322	Protein conserved in bacteria
XAV_21430	COG0531	amino acid
XAV_21465	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XAV_21470	COG0861	Integral membrane protein TerC family
XAV_21480	COG0584	glycerophosphoryl diester phosphodiesterase
XAV_21495	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XAV_21510	COG0706	membrane insertase activity
XAV_21515	COG0594	ribonuclease P activity
XAV_21600	COG2336	PFAM SpoVT AbrB
XAV_21605	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XAV_21610	COG1192	Involved in chromosome partitioning