locus-tag	class	description
HG421_00025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HG421_00030	COG2354	Protein conserved in bacteria
HG421_00045	COG0297	glycogen (starch) synthase activity
HG421_00055	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HG421_00080	COG0702	epimerase
HG421_00085	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_00115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG421_00120	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_00130	COG0513	Belongs to the DEAD box helicase family
HG421_00145	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG421_00160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HG421_00175	COG3104	oligopeptide transport
HG421_00200	COG2852	Protein conserved in bacteria
HG421_00205	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HG421_00220	COG1320	monovalent cation:proton antiporter activity
HG421_00225	COG2212	antiporter activity
HG421_00235	COG0651	ATP synthesis coupled electron transport
HG421_00240	COG1006	Multisubunit Na H antiporter MnhC subunit
HG421_00245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HG421_00245	COG2111	Na H antiporter
HG421_00265	COG3179	chitinase
HG421_00290	COG0484	heat shock protein binding
HG421_00300	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HG421_00305	COG0456	acetyltransferase
HG421_00380	COG5297	Belongs to the glycosyl hydrolase family 6
HG421_00435	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG421_00525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HG421_00535	COG0134	indole-3-glycerol-phosphate synthase activity
HG421_00545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG421_00550	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HG421_00560	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HG421_00570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HG421_00585	COG1051	belongs to the nudix hydrolase family
HG421_00625	COG0316	Belongs to the HesB IscA family
HG421_00630	COG2816	NAD+ diphosphatase activity
HG421_00635	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HG421_00660	COG3039	Transposase
HG421_00690	COG2814	Major facilitator Superfamily
HG421_00695	COG1289	transmembrane transporter activity
HG421_00700	COG0151	Belongs to the GarS family
HG421_00705	COG0138	bifunctional purine biosynthesis protein purh
HG421_00710	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG421_00715	COG2267	carboxylic ester hydrolase activity
HG421_00720	COG2453	phosphatase
HG421_00720	COG0671	phosphoesterase, PA-phosphatase related
HG421_00745	COG4589	Belongs to the CDS family
HG421_00750	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HG421_00785	COG0439	Biotin carboxylase
HG421_00790	COG0511	ligase activity, forming carbon-carbon bonds
HG421_00795	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HG421_00805	COG1324	tolerance protein
HG421_00810	COG2356	endonuclease I
HG421_00820	COG0459	protein refolding
HG421_00835	COG3550	peptidyl-serine autophosphorylation
HG421_00840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HG421_00855	COG3386	PFAM SMP-30 Gluconolaconase
HG421_00865	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HG421_00890	COG2353	YceI-like domain
HG421_00895	COG3385	transposase activity
HG421_00915	COG3052	prosthetic group binding
HG421_00950	COG1802	Transcriptional regulator
HG421_01045	COG3039	Transposase
HG421_01155	COG0583	DNA-binding transcription factor activity
HG421_01160	COG4221	oxidoreductase activity
HG421_01185	COG0435	Glutathione S-transferase
HG421_01215	COG0823	Involved in the tonB-independent uptake of proteins
HG421_01215	COG1506	peptidase
HG421_01225	COG3706	GGDEF domain
HG421_01240	COG0697	spore germination
HG421_01255	COG4305	rare lipoprotein A
HG421_01260	COG1113	amino acid transport
HG421_01265	COG0598	Magnesium transport protein CorA
HG421_01350	COG3188	usher protein
HG421_01385	COG0784	Response regulator, receiver
HG421_01385	COG2205	protein histidine kinase activity
HG421_01410	COG5297	Belongs to the glycosyl hydrolase family 6
HG421_01410	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HG421_01415	COG0659	secondary active sulfate transmembrane transporter activity
HG421_01420	COG3706	GGDEF domain
HG421_01430	COG2943	transferase activity, transferring hexosyl groups
HG421_01440	COG3275	phosphorelay sensor kinase activity
HG421_01450	COG0181	hydroxymethylbilane synthase activity
HG421_01475	COG1505	serine-type exopeptidase activity
HG421_01480	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HG421_01495	COG2832	Protein of unknown function (DUF454)
HG421_01505	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HG421_01515	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HG421_01520	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HG421_01525	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HG421_01550	COG2226	methyltransferase
HG421_01555	COG3300	MHYT domain
HG421_01555	COG5001	Diguanylate cyclase
HG421_01560	COG0308	aminopeptidase N
HG421_01610	COG3284	Transcriptional regulator
HG421_01615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HG421_01620	COG1077	Cell shape determining protein MreB Mrl
HG421_01625	COG1792	Involved in formation and maintenance of cell shape
HG421_01640	COG0772	Belongs to the SEDS family
HG421_01650	COG2951	lytic endotransglycosylase activity
HG421_01655	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HG421_01660	COG1686	Belongs to the peptidase S11 family
HG421_01665	COG3385	transposase activity
HG421_01675	COG2921	Belongs to the UPF0250 family
HG421_01685	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HG421_01710	COG1056	cytidyltransferase-related domain
HG421_01710	COG1051	belongs to the nudix hydrolase family
HG421_01745	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HG421_01750	COG0673	inositol 2-dehydrogenase activity
HG421_01755	COG2823	Periplasmic or secreted lipoprotein
HG421_01760	COG4251	negative regulation of phosphorylation
HG421_01765	COG0784	Response regulator, receiver
HG421_01770	COG4191	Histidine kinase
HG421_01775	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HG421_01780	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_01825	COG1459	type II secretion system
HG421_01830	COG2165	general secretion pathway protein
HG421_01845	COG4795	General secretion pathway protein
HG421_01875	COG3250	beta-galactosidase activity
HG421_01890	COG2188	Transcriptional regulator
HG421_01900	COG1609	Transcriptional regulator
HG421_01905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HG421_01910	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HG421_01945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HG421_01955	COG0795	lipopolysaccharide-transporting ATPase activity
HG421_01965	COG4974	Belongs to the 'phage' integrase family
HG421_01970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HG421_01975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HG421_01975	COG0047	phosphoribosylformylglycinamidine synthase activity
HG421_01990	COG1404	Belongs to the peptidase S8 family
HG421_01995	COG5295	Hep Hag repeat protein
HG421_02000	COG1404	Belongs to the peptidase S8 family
HG421_02005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HG421_02010	COG1459	type II secretion system
HG421_02015	COG2165	general secretion pathway protein
HG421_02020	COG4970	Tfp pilus assembly protein FimT
HG421_02025	COG2165	general secretion pathway protein
HG421_02030	COG4795	General secretion pathway protein
HG421_02035	COG3156	type II secretion system protein K
HG421_02040	COG3166	PFAM Fimbrial assembly family protein
HG421_02055	COG1450	Type ii and iii secretion system protein
HG421_02070	COG2188	Transcriptional regulator
HG421_02115	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HG421_02130	COG1215	transferase activity, transferring glycosyl groups
HG421_02135	COG1215	transferase activity, transferring glycosyl groups
HG421_02140	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HG421_02145	COG0457	Tetratricopeptide repeat
HG421_02165	COG0242	peptide deformylase activity
HG421_02170	COG0745	RESPONSE REGULATOR receiver
HG421_02180	COG0642	Histidine kinase
HG421_02185	COG0612	Peptidase, M16
HG421_02200	COG0714	Associated with various cellular activities
HG421_02225	COG0488	(ABC) transporter
HG421_02235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HG421_02240	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HG421_02250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HG421_02250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HG421_02270	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HG421_02280	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HG421_02295	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HG421_02300	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HG421_02305	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HG421_02310	COG2205	protein histidine kinase activity
HG421_02315	COG0745	RESPONSE REGULATOR receiver
HG421_02325	COG0277	FAD linked oxidase domain protein
HG421_02330	COG1988	membrane-bound metal-dependent
HG421_02335	COG0792	nuclease activity
HG421_02380	COG3116	cell division
HG421_02390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HG421_02395	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HG421_02400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG421_02410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HG421_02415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HG421_02420	COG1181	Belongs to the D-alanine--D-alanine ligase family
HG421_02425	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HG421_02450	COG0739	heme binding
HG421_02465	COG0494	nUDIX hydrolase
HG421_02475	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HG421_02480	COG0604	alcohol dehydrogenase
HG421_02480	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_02480	COG3321	synthase
HG421_02505	COG0366	Alpha amylase catalytic
HG421_02540	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HG421_02545	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HG421_02555	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HG421_02580	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HG421_02590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG421_02595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HG421_02600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HG421_02605	COG0667	Aldo Keto reductase
HG421_02615	COG4771	TonB-dependent receptor
HG421_02635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HG421_02640	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HG421_02650	COG2175	clavaminate synthase activity
HG421_02660	COG4181	ATPase activity
HG421_02675	COG0642	Histidine kinase
HG421_02690	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HG421_02710	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HG421_02725	COG3829	transcription factor binding
HG421_02735	COG1116	anion transmembrane transporter activity
HG421_02740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HG421_02750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HG421_02775	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HG421_02780	COG2967	ApaG domain
HG421_02790	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HG421_02795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HG421_02800	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HG421_02805	COG0123	including yeast histone deacetylase and acetoin utilization protein
HG421_02810	COG2096	Adenosyltransferase
HG421_02820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HG421_02825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HG421_02860	COG3384	dioxygenase
HG421_02865	COG0583	DNA-binding transcription factor activity
HG421_02870	COG0318	PFAM AMP-dependent synthetase and ligase
HG421_02880	COG1024	Enoyl-CoA hydratase
HG421_02900	COG3386	PFAM SMP-30 Gluconolaconase
HG421_02925	COG0697	spore germination
HG421_02930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG421_02955	COG2197	response regulator
HG421_02965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG421_02975	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HG421_02980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HG421_02985	COG0583	DNA-binding transcription factor activity
HG421_02990	COG3634	alkyl hydroperoxide reductase activity
HG421_03000	COG2890	protein-(glutamine-N5) methyltransferase activity
HG421_03090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HG421_03095	COG1404	Belongs to the peptidase S8 family
HG421_03100	COG1404	Belongs to the peptidase S8 family
HG421_03105	COG1404	Belongs to the peptidase S8 family
HG421_03115	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HG421_03135	COG1295	ribonuclease BN
HG421_03140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG421_03160	COG0521	Mo-molybdopterin cofactor biosynthetic process
HG421_03170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HG421_03175	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HG421_03185	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HG421_03190	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HG421_03200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG421_03205	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HG421_03210	COG0193	aminoacyl-tRNA hydrolase activity
HG421_03215	COG0012	GTP binding
HG421_03235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HG421_03245	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HG421_03250	COG0250	Participates in transcription elongation, termination and antitermination
HG421_03255	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HG421_03260	COG0081	regulation of translation
HG421_03265	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HG421_03270	COG0222	ribosome binding
HG421_03275	COG0085	RNA polymerase activity
HG421_03280	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HG421_03295	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG421_03300	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HG421_03305	COG0051	transcription antitermination factor activity, RNA binding
HG421_03315	COG0088	Forms part of the polypeptide exit tunnel
HG421_03325	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HG421_03330	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HG421_03340	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HG421_03345	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HG421_03350	COG0255	Belongs to the universal ribosomal protein uL29 family
HG421_03355	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HG421_03365	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HG421_03400	COG1841	ribosomal large subunit assembly
HG421_03405	COG0200	Binds to the 23S rRNA
HG421_03410	COG0201	protein transport
HG421_03435	COG0203	ribosomal protein L17
HG421_03440	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HG421_03445	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HG421_03455	COG0154	amidase activity
HG421_03470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG421_03475	COG0039	L-malate dehydrogenase activity
HG421_03480	COG0625	glutathione transferase activity
HG421_03495	COG0446	pyridine nucleotide-disulphide oxidoreductase
HG421_03495	COG1902	pentaerythritol trinitrate reductase activity
HG421_03500	COG0604	alcohol dehydrogenase
HG421_03505	COG2885	chlorophyll binding
HG421_03525	COG0156	8-amino-7-oxononanoate synthase activity
HG421_03530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HG421_03535	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HG421_03540	COG4208	sulfate ABC transporter
HG421_03545	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HG421_03575	COG0406	alpha-ribazole phosphatase activity
HG421_03585	COG0285	dihydrofolate synthase activity
HG421_03605	COG2833	Protein of unknown function (DUF455)
HG421_03610	COG3291	Pkd domain containing protein
HG421_03620	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG421_03625	COG0671	phosphoesterase, PA-phosphatase related
HG421_03630	COG0438	transferase activity, transferring glycosyl groups
HG421_03640	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HG421_03655	COG4783	chaperone-mediated protein folding
HG421_03670	COG0473	3-isopropylmalate dehydrogenase activity
HG421_03710	COG0544	peptidyl-prolyl cis-trans isomerase activity
HG421_03720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HG421_03750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HG421_03760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG421_03770	COG0328	RNA-DNA hybrid ribonuclease activity
HG421_03775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HG421_03780	COG0631	protein serine/threonine phosphatase activity
HG421_03795	COG0859	PFAM glycosyl transferase family 9
HG421_03805	COG1234	tRNA 3'-trailer cleavage
HG421_03810	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HG421_03820	COG0315	cyclic pyranopterin monophosphate synthase activity
HG421_03825	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HG421_03830	COG0314	molybdopterin synthase activity
HG421_03870	COG2003	Belongs to the UPF0758 family
HG421_03900	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HG421_03925	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HG421_03930	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HG421_03935	COG0537	adenosine 5'-monophosphoramidase activity
HG421_03955	COG0714	Associated with various cellular activities
HG421_03975	COG0424	maF-like protein
HG421_03980	COG1399	metal-binding, possibly nucleic acid-binding protein
HG421_03990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HG421_04020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG421_04025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HG421_04050	COG3829	transcription factor binding
HG421_04070	COG3609	addiction module antidote protein, CC2985 family
HG421_04085	COG4771	TonB-dependent receptor
HG421_04095	COG2373	Large extracellular alpha-helical protein
HG421_04115	COG4953	penicillin-binding protein 1C
HG421_04130	COG0678	peroxiredoxin activity
HG421_04150	COG0330	HflC and HflK could
HG421_04155	COG0330	HflC and HflK could
HG421_04220	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_04225	COG1309	transcriptional regulator
HG421_04255	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HG421_04260	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HG421_04265	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HG421_04280	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HG421_04300	COG1309	transcriptional regulator
HG421_04310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HG421_04320	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_04330	COG3537	Alpha-1,2-mannosidase
HG421_04365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HG421_04370	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HG421_04375	COG2080	2 iron, 2 sulfur cluster binding
HG421_04410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HG421_04425	COG0587	DNA-directed DNA polymerase activity
HG421_04435	COG1297	OPT oligopeptide transporter protein
HG421_04445	COG1506	peptidase
HG421_04445	COG0823	Involved in the tonB-independent uptake of proteins
HG421_04455	COG2207	Transcriptional regulator
HG421_04455	COG1917	Cupin 2, conserved barrel domain protein
HG421_04460	COG0753	catalase activity
HG421_04465	COG0656	L-ascorbic acid biosynthetic process
HG421_04470	COG2272	Belongs to the type-B carboxylesterase lipase family
HG421_04475	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG421_04475	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG421_04480	COG2814	Major facilitator Superfamily
HG421_04495	COG2194	sulfuric ester hydrolase activity
HG421_04510	COG0745	RESPONSE REGULATOR receiver
HG421_04515	COG0642	Histidine kinase
HG421_04525	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HG421_04530	COG2894	cell division
HG421_04535	COG0850	regulation of cytokinetic process
HG421_04545	COG4585	Histidine kinase
HG421_04550	COG2197	response regulator
HG421_04565	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HG421_04590	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HG421_04600	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HG421_04620	COG1946	Acyl-CoA thioesterase
HG421_04635	COG0824	Thioesterase
HG421_04640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HG421_04645	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HG421_04650	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HG421_04655	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG421_04660	COG0268	Binds directly to 16S ribosomal RNA
HG421_04665	COG0728	peptidoglycan biosynthetic process
HG421_04670	COG0196	riboflavin kinase activity
HG421_04685	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HG421_04700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HG421_04705	COG1845	cytochrome c oxidase, subunit III
HG421_04710	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HG421_04725	COG3152	Membrane
HG421_04735	COG2207	Transcriptional regulator
HG421_04745	COG0326	Molecular chaperone. Has ATPase activity
HG421_04755	COG1366	Belongs to the anti-sigma-factor antagonist family
HG421_04760	COG1366	Belongs to the anti-sigma-factor antagonist family
HG421_04765	COG2172	sigma factor antagonist activity
HG421_04785	COG4771	TonB-dependent receptor
HG421_04795	COG5507	3-demethylubiquinone-9 3-methyltransferase
HG421_04800	COG2205	protein histidine kinase activity
HG421_04810	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HG421_04815	COG3850	Histidine kinase
HG421_04815	COG3437	response regulator, receiver
HG421_04815	COG4999	Histidine kinase
HG421_04815	COG2205	protein histidine kinase activity
HG421_04820	COG4191	Histidine kinase
HG421_04820	COG0784	Response regulator, receiver
HG421_04840	COG3534	alpha-L-arabinofuranosidase
HG421_04850	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HG421_04855	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG421_04860	COG2070	2-Nitropropane dioxygenase
HG421_04870	COG0228	four-way junction DNA binding
HG421_04890	COG0534	Mate efflux family protein
HG421_04900	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HG421_04910	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HG421_04915	COG0840	transmembrane signaling receptor activity
HG421_04930	COG3250	beta-galactosidase activity
HG421_04935	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HG421_04955	COG1960	acyl-CoA dehydrogenase activity
HG421_04960	COG1024	Enoyl-CoA hydratase
HG421_04995	COG0457	Tetratricopeptide repeat
HG421_05005	COG1250	3-hydroxyacyl-CoA dehydrogenase
HG421_05005	COG1024	Enoyl-CoA hydratase
HG421_05020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG421_05025	COG0481	GTPase activity
HG421_05050	COG1381	Involved in DNA repair and RecF pathway recombination
HG421_05060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HG421_05065	COG2954	triphosphatase activity
HG421_05070	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HG421_05075	COG0493	'glutamate synthase
HG421_05075	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HG421_05080	COG3046	protein related to deoxyribodipyrimidine photolyase
HG421_05085	COG1472	Belongs to the glycosyl hydrolase 3 family
HG421_05100	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HG421_05105	COG1278	Cold shock
HG421_05110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HG421_05120	COG1201	RNA secondary structure unwinding
HG421_05125	COG1793	dna ligase
HG421_05135	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HG421_05135	COG1793	dna ligase
HG421_05165	COG0183	Belongs to the thiolase family
HG421_05185	COG1451	nucleotide metabolic process
HG421_05190	COG5487	UPF0391 membrane protein
HG421_05200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HG421_05230	COG1047	Peptidyl-prolyl cis-trans
HG421_05240	COG2824	Alkylphosphonate utilization operon protein PhnA
HG421_05255	COG1902	pentaerythritol trinitrate reductase activity
HG421_05260	COG2814	Major facilitator Superfamily
HG421_05290	COG0392	lysyltransferase activity
HG421_05290	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HG421_05300	COG0251	oxidation-reduction process
HG421_05305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HG421_05320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HG421_05345	COG1595	DNA-templated transcription, initiation
HG421_05360	COG2878	Part of a membrane complex involved in electron transport
HG421_05370	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG421_05370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG421_05390	COG0346	lactoylglutathione lyase activity
HG421_05395	COG0833	amino acid
HG421_05400	COG2040	homocysteine
HG421_05410	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HG421_05430	COG1695	Transcriptional regulator
HG421_05460	COG0825	malonyl-CoA metabolic process
HG421_05470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HG421_05475	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG421_05480	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG421_05490	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG421_05500	COG0750	zinc metalloprotease
HG421_05505	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HG421_05510	COG0575	Belongs to the CDS family
HG421_05520	COG0233	cytoplasmic translational termination
HG421_05525	COG0528	UMP kinase activity
HG421_05535	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HG421_05540	COG0052	Belongs to the universal ribosomal protein uS2 family
HG421_05580	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HG421_05590	COG1393	Belongs to the ArsC family
HG421_05595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HG421_05605	COG0367	asparagine synthase
HG421_05615	COG4774	siderophore transport
HG421_05655	COG1566	PFAM secretion protein HlyD family protein
HG421_05660	COG2814	Major facilitator Superfamily
HG421_05695	COG3104	oligopeptide transport
HG421_05725	COG0339	signal peptide processing
HG421_05730	COG0386	Belongs to the glutathione peroxidase family
HG421_05755	COG0288	reversible hydration of carbon dioxide
HG421_05785	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HG421_05790	COG0084	hydrolase, TatD family'
HG421_05825	COG1960	acyl-CoA dehydrogenase activity
HG421_05840	COG0367	asparagine synthase
HG421_05850	COG0305	Participates in initiation and elongation during chromosome replication
HG421_05855	COG0415	Belongs to the DNA photolyase family
HG421_05865	COG0583	DNA-binding transcription factor activity
HG421_05880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG421_05900	COG3706	GGDEF domain
HG421_05910	COG3706	GGDEF domain
HG421_05935	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HG421_05950	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG421_05960	COG0497	DNA recombination
HG421_05965	COG1420	regulation of RNA biosynthetic process
HG421_05970	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HG421_05975	COG0443	Heat shock 70 kDa protein
HG421_05980	COG0484	heat shock protein binding
HG421_05985	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HG421_05990	COG1605	Chorismate mutase
HG421_05990	COG0287	Prephenate dehydrogenase
HG421_06015	COG0583	DNA-binding transcription factor activity
HG421_06020	COG1132	(ABC) transporter
HG421_06055	COG2850	peptidyl-arginine hydroxylation
HG421_06070	COG1253	flavin adenine dinucleotide binding
HG421_06100	COG1131	(ABC) transporter
HG421_06105	COG1725	Transcriptional regulator
HG421_06115	COG0386	Belongs to the glutathione peroxidase family
HG421_06125	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HG421_06135	COG2900	Belongs to the SlyX family
HG421_06160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HG421_06170	COG1410	methionine synthase
HG421_06170	COG0646	methionine synthase
HG421_06175	COG0646	methionine synthase
HG421_06175	COG1410	methionine synthase
HG421_06180	COG2226	methyltransferase
HG421_06185	COG1960	acyl-CoA dehydrogenase activity
HG421_06200	COG0557	exoribonuclease II activity
HG421_06210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HG421_06220	COG3447	MASE1 domain protein
HG421_06220	COG5001	Diguanylate cyclase
HG421_06220	COG5002	protein histidine kinase activity
HG421_06225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HG421_06230	COG0704	Plays a role in the regulation of phosphate uptake
HG421_06240	COG0581	inorganic phosphate transmembrane transporter activity
HG421_06245	COG0573	inorganic phosphate transmembrane transporter activity
HG421_06250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HG421_06290	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HG421_06300	COG1024	Enoyl-CoA hydratase
HG421_06310	COG0494	nUDIX hydrolase
HG421_06375	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HG421_06390	COG2925	Exonuclease
HG421_06395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HG421_06400	COG3844	kynureninase activity
HG421_06415	COG0288	reversible hydration of carbon dioxide
HG421_06445	COG0017	Asparaginyl-tRNA synthetase
HG421_06450	COG0316	Belongs to the HesB IscA family
HG421_06455	COG0360	Binds together with S18 to 16S ribosomal RNA
HG421_06460	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HG421_06475	COG3115	cell septum assembly
HG421_06480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HG421_06485	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HG421_06490	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HG421_06500	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HG421_06510	COG4993	Dehydrogenase
HG421_06525	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HG421_06535	COG2986	histidine ammonia-lyase
HG421_06540	COG1228	amidohydrolase
HG421_06580	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HG421_06585	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HG421_06590	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HG421_06595	COG0077	Prephenate dehydratase
HG421_06595	COG1605	Chorismate mutase
HG421_06600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HG421_06615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HG421_06620	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HG421_06625	COG0583	DNA-binding transcription factor activity
HG421_06640	COG0840	transmembrane signaling receptor activity
HG421_06645	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HG421_06650	COG4191	Histidine kinase
HG421_06650	COG0784	Response regulator, receiver
HG421_06665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG421_06675	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HG421_06685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HG421_06700	COG1595	DNA-templated transcription, initiation
HG421_06735	COG2244	polysaccharide biosynthetic process
HG421_06740	COG1215	transferase activity, transferring glycosyl groups
HG421_06765	COG2264	protein methyltransferase activity
HG421_06770	COG0438	transferase activity, transferring glycosyl groups
HG421_06775	COG0438	transferase activity, transferring glycosyl groups
HG421_06790	COG1136	(ABC) transporter
HG421_06795	COG1132	(ABC) transporter
HG421_06800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HG421_06815	COG1253	flavin adenine dinucleotide binding
HG421_06830	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HG421_06845	COG0504	CTP synthase activity
HG421_06860	COG0148	phosphopyruvate hydratase activity
HG421_06865	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HG421_06870	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HG421_06875	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HG421_06880	COG0585	pseudouridine synthase activity
HG421_06885	COG2840	Smr protein MutS2
HG421_06890	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HG421_06895	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HG421_06900	COG1238	metal cluster binding
HG421_06910	COG3737	Protein of unknown function (DUF498/DUF598)
HG421_06915	COG1534	Rna-binding protein
HG421_06920	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HG421_06930	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HG421_06935	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HG421_06945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HG421_06950	COG1546	Belongs to the CinA family
HG421_06955	COG4771	TonB-dependent receptor
HG421_06970	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HG421_06975	COG2137	regulation of response to DNA damage stimulus
HG421_06980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HG421_06985	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG421_07000	COG1741	Belongs to the pirin family
HG421_07005	COG0583	DNA-binding transcription factor activity
HG421_07030	COG0352	thiamine-phosphate diphosphorylase activity
HG421_07030	COG0351	phosphomethylpyrimidine kinase
HG421_07045	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HG421_07050	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG421_07065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG421_07075	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HG421_07080	COG3734	2-keto-3-deoxy-galactonokinase
HG421_07090	COG4948	Mandelate Racemase Muconate Lactonizing
HG421_07095	COG0800	Aldolase
HG421_07135	COG1501	Belongs to the glycosyl hydrolase 31 family
HG421_07145	COG1070	Carbohydrate kinase
HG421_07155	COG0477	Major facilitator Superfamily
HG421_07185	COG0617	tRNA 3'-terminal CCA addition
HG421_07200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HG421_07205	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HG421_07230	COG1472	Belongs to the glycosyl hydrolase 3 family
HG421_07265	COG5001	Diguanylate cyclase
HG421_07265	COG4251	negative regulation of phosphorylation
HG421_07265	COG3706	GGDEF domain
HG421_07265	COG2203	Gaf domain
HG421_07270	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HG421_07275	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HG421_07285	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HG421_07290	COG0671	phosphoesterase, PA-phosphatase related
HG421_07300	COG1794	racemase activity, acting on amino acids and derivatives
HG421_07305	COG0697	spore germination
HG421_07310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HG421_07330	COG1012	belongs to the aldehyde dehydrogenase family
HG421_07380	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HG421_07410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG421_07415	COG0124	histidyl-tRNA synthetase
HG421_07430	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HG421_07435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HG421_07440	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HG421_07440	COG0131	Imidazoleglycerol-phosphate dehydratase
HG421_07445	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HG421_07455	COG0107	imidazoleglycerol-phosphate synthase activity
HG421_07460	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HG421_07460	COG0140	phosphoribosyl-ATP diphosphatase activity
HG421_07475	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HG421_07480	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HG421_07490	COG0531	amino acid
HG421_07495	COG0531	amino acid
HG421_07510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HG421_07515	COG0277	FAD linked oxidase domain protein
HG421_07530	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HG421_07570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HG421_07575	COG2258	MOSC domain
HG421_07580	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HG421_07585	COG0505	Belongs to the CarA family
HG421_07600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HG421_07605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HG421_07615	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HG421_07630	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HG421_07640	COG2205	protein histidine kinase activity
HG421_07640	COG2198	Histidine kinase
HG421_07640	COG0784	Response regulator, receiver
HG421_07645	COG0784	Response regulator, receiver
HG421_07645	COG2198	Histidine kinase
HG421_07645	COG2205	protein histidine kinase activity
HG421_07650	COG1024	Enoyl-CoA hydratase
HG421_07655	COG0318	PFAM AMP-dependent synthetase and ligase
HG421_07690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HG421_07715	COG0840	transmembrane signaling receptor activity
HG421_07725	COG0835	chemotaxis
HG421_07735	COG0840	transmembrane signaling receptor activity
HG421_07740	COG0840	transmembrane signaling receptor activity
HG421_07745	COG0840	transmembrane signaling receptor activity
HG421_07750	COG0840	transmembrane signaling receptor activity
HG421_07755	COG0840	transmembrane signaling receptor activity
HG421_07760	COG0840	transmembrane signaling receptor activity
HG421_07765	COG0840	transmembrane signaling receptor activity
HG421_07780	COG0840	transmembrane signaling receptor activity
HG421_07795	COG0745	RESPONSE REGULATOR receiver
HG421_07805	COG0835	chemotaxis
HG421_07810	COG1192	Involved in chromosome partitioning
HG421_07815	COG1360	Flagellar Motor Protein
HG421_07820	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HG421_07955	COG0784	Response regulator, receiver
HG421_07955	COG2198	Histidine kinase
HG421_07955	COG0643	Histidine kinase
HG421_08020	COG5001	Diguanylate cyclase
HG421_08020	COG3300	MHYT domain
HG421_08025	COG3300	MHYT domain
HG421_08025	COG5001	Diguanylate cyclase
HG421_08030	COG1684	flagellar biosynthetic protein fliR
HG421_08095	COG1677	Flagellar hook-basal body complex protein FliE
HG421_08140	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_08145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HG421_08165	COG2201	protein-glutamate methylesterase activity
HG421_08170	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HG421_08195	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HG421_08200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HG421_08220	COG1706	bacterial-type flagellum-dependent cell motility
HG421_08225	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HG421_08235	COG4787	bacterial-type flagellum-dependent cell motility
HG421_08245	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HG421_08250	COG1558	bacterial-type flagellum-dependent cell motility
HG421_08260	COG0835	chemotaxis
HG421_08260	COG0784	Response regulator, receiver
HG421_08280	COG4191	Histidine kinase
HG421_08310	COG2915	High frequency lysogenization protein hflD homolog
HG421_08315	COG0482	sulfurtransferase activity
HG421_08330	COG0542	response to heat
HG421_08340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HG421_08350	COG0492	ferredoxin-NADP+ reductase activity
HG421_08355	COG1674	ftsk spoiiie
HG421_08375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG421_08380	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HG421_08385	COG0183	Belongs to the thiolase family
HG421_08390	COG1250	3-hydroxyacyl-CoA dehydrogenase
HG421_08390	COG1024	Enoyl-CoA hydratase
HG421_08425	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG421_08430	COG1160	GTP binding
HG421_08440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HG421_08470	COG0303	'Molybdopterin
HG421_08475	COG0746	molybdenum cofactor guanylyltransferase activity
HG421_08485	COG1648	precorrin-2 dehydrogenase activity
HG421_08485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HG421_08495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG421_08500	COG2223	nitrite transmembrane transporter activity
HG421_08505	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HG421_08515	COG0243	molybdopterin cofactor binding
HG421_08540	COG5001	Diguanylate cyclase
HG421_08575	COG1238	metal cluster binding
HG421_08585	COG0363	glucosamine-6-phosphate deaminase activity
HG421_08610	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_08620	COG0688	phosphatidylethanolamine metabolic process
HG421_08635	COG3220	belongs to the UPF0276 family
HG421_08670	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HG421_08670	COG0316	Belongs to the HesB IscA family
HG421_08675	COG2154	pterin-4-alpha-carbinolamine dehydratase
HG421_08685	COG0428	transporter
HG421_08690	COG3064	Membrane
HG421_08700	COG1530	ribonuclease E activity
HG421_08735	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HG421_08760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG421_08765	COG0322	excinuclease ABC activity
HG421_08775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HG421_08780	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HG421_08790	COG1663	tetraacyldisaccharide 4'-kinase activity
HG421_08795	COG1132	(ABC) transporter
HG421_08805	COG0811	peptide transport
HG421_08820	COG1136	(ABC) transporter
HG421_08825	COG4591	ABC-type transport system involved in lipoprotein release permease component
HG421_08840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HG421_08855	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HG421_08870	COG0354	folic acid binding
HG421_08880	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HG421_08885	COG0837	glucose binding
HG421_08890	COG0363	glucosamine-6-phosphate deaminase activity
HG421_08895	COG0129	dihydroxy-acid dehydratase activity
HG421_08900	COG0800	Aldolase
HG421_08965	COG5002	protein histidine kinase activity
HG421_08965	COG0784	Response regulator, receiver
HG421_08965	COG2205	protein histidine kinase activity
HG421_08970	COG2183	response to ionizing radiation
HG421_08990	COG3243	poly(R)-hydroxyalkanoic acid synthase
HG421_09000	COG1183	phosphatidylcholine synthase activity
HG421_09005	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_09030	COG0668	transmembrane transport
HG421_09035	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HG421_09050	COG1914	H( )-stimulated, divalent metal cation uptake system
HG421_09060	COG2814	Major facilitator Superfamily
HG421_09075	COG1335	isochorismatase
HG421_09085	COG4585	Histidine kinase
HG421_09090	COG2197	response regulator
HG421_09110	COG0519	Catalyzes the synthesis of GMP from XMP
HG421_09110	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HG421_09120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HG421_09130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HG421_09130	COG0475	glutathione-regulated potassium exporter activity
HG421_09135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HG421_09150	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HG421_09165	COG0539	negative regulation of cytoplasmic translation
HG421_09170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HG421_09185	COG2957	Belongs to the agmatine deiminase family
HG421_09190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG421_09215	COG0395	ABC-type sugar transport system, permease component
HG421_09220	COG1175	transmembrane transport
HG421_09225	COG1653	transport
HG421_09250	COG2350	Protein conserved in bacteria
HG421_09255	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HG421_09260	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HG421_09265	COG1187	pseudouridine synthase activity
HG421_09285	COG0436	Aminotransferase
HG421_09335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HG421_09350	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HG421_09355	COG4988	ABC transporter
HG421_09365	COG1294	oxidase, subunit
HG421_09390	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HG421_09405	COG0165	Argininosuccinate lyase
HG421_09420	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HG421_09425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HG421_09430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HG421_09435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HG421_09440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HG421_09445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HG421_09450	COG0137	argininosuccinate synthase activity
HG421_09455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HG421_09465	COG0215	cysteine-tRNA ligase activity
HG421_09470	COG2166	iron-sulfur cluster assembly
HG421_09490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG421_09505	COG4303	Ethanolamine ammonia lyase large subunit
HG421_09510	COG4302	ethanolamine ammonia-lyase activity
HG421_09545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HG421_09550	COG0402	S-adenosylhomocysteine deaminase activity
HG421_09565	COG1509	lysine 2,3-aminomutase activity
HG421_09570	COG3300	MHYT domain
HG421_09570	COG5001	Diguanylate cyclase
HG421_09585	COG0483	inositol monophosphate 1-phosphatase activity
HG421_09590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HG421_09610	COG0513	Belongs to the DEAD box helicase family
HG421_09615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HG421_09620	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HG421_09645	COG4681	YaeQ
HG421_09650	COG2081	HI0933 family
HG421_09660	COG0501	Belongs to the peptidase M48B family
HG421_09665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG421_09670	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_09690	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HG421_09695	COG0860	N-Acetylmuramoyl-L-alanine amidase
HG421_09705	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HG421_09705	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HG421_09710	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HG421_09725	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HG421_09750	COG0582	viral genome integration into host DNA
HG421_09790	COG0835	chemotaxis
HG421_09795	COG0840	transmembrane signaling receptor activity
HG421_09800	COG2094	Belongs to the DNA glycosylase MPG family
HG421_09805	COG1201	RNA secondary structure unwinding
HG421_09820	COG2969	positive regulation of protein catabolic process
HG421_09825	COG0625	glutathione transferase activity
HG421_09830	COG2857	Cytochrome c1
HG421_09835	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HG421_09840	COG0723	plastoquinol--plastocyanin reductase activity
HG421_09845	COG0741	lytic transglycosylase activity
HG421_09865	COG1702	phosphate starvation-inducible protein PhoH
HG421_09875	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HG421_09885	COG4535	Mg2 and Co2 transporter CorC
HG421_09900	COG1012	belongs to the aldehyde dehydrogenase family
HG421_09905	COG1177	transmembrane transport
HG421_09910	COG1176	ABC-type spermidine putrescine transport system, permease component I
HG421_09920	COG3842	ATPase activity
HG421_09955	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HG421_09960	COG0174	glutamine synthetase
HG421_09965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG421_09975	COG0477	Major facilitator Superfamily
HG421_09985	COG0243	molybdopterin cofactor binding
HG421_09990	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HG421_09995	COG2223	nitrite transmembrane transporter activity
HG421_10010	COG2733	membrane
HG421_10015	COG2205	protein histidine kinase activity
HG421_10015	COG0784	Response regulator, receiver
HG421_10015	COG5002	protein histidine kinase activity
HG421_10025	COG0477	Major facilitator Superfamily
HG421_10080	COG2902	Dehydrogenase
HG421_10090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG421_10095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG421_10100	COG1609	Transcriptional regulator
HG421_10105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HG421_10105	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HG421_10110	COG1105	Belongs to the carbohydrate kinase PfkB family
HG421_10115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HG421_10115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HG421_10130	COG3385	transposase activity
HG421_10175	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HG421_10185	COG1862	Preprotein translocase
HG421_10195	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HG421_10245	COG0405	Gamma-glutamyltransferase
HG421_10250	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HG421_10265	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HG421_10270	COG0742	ribosomal rna small subunit methyltransferase
HG421_10275	COG0326	Molecular chaperone. Has ATPase activity
HG421_10340	COG3039	Transposase
HG421_10365	COG0531	amino acid
HG421_10380	COG0006	proline dipeptidase activity
HG421_10390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG421_10405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG421_10410	COG3938	Belongs to the proline racemase family
HG421_10420	COG0552	protein localization to endoplasmic reticulum
HG421_10435	COG4191	Histidine kinase
HG421_10435	COG0784	Response regulator, receiver
HG421_10450	COG3040	lipid binding
HG421_10465	COG1960	acyl-CoA dehydrogenase activity
HG421_10475	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HG421_10495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG421_10505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HG421_10530	COG0438	transferase activity, transferring glycosyl groups
HG421_10540	COG0438	transferase activity, transferring glycosyl groups
HG421_10545	COG0438	transferase activity, transferring glycosyl groups
HG421_10595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG421_10595	COG0072	phenylalanine-tRNA ligase activity
HG421_10600	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HG421_10615	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HG421_10620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HG421_10645	COG1082	Xylose isomerase domain protein TIM barrel
HG421_10660	COG0366	Alpha amylase catalytic
HG421_10735	COG3702	type iv secretory pathway
HG421_10755	COG2948	multi-organism process
HG421_10785	COG0556	nucleotide-excision repair
HG421_10830	COG1611	Belongs to the LOG family
HG421_10840	COG2095	MarC family integral membrane protein
HG421_10850	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HG421_10885	COG1185	polyribonucleotide nucleotidyltransferase activity
HG421_10890	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HG421_10895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HG421_10900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HG421_10905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HG421_10910	COG0195	Participates in both transcription termination and antitermination
HG421_10915	COG0779	Required for maturation of 30S ribosomal subunits
HG421_10925	COG1007	ATP synthesis coupled electron transport
HG421_10955	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HG421_10965	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HG421_10970	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HG421_10975	COG0649	NAD binding
HG421_10980	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG421_10990	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG421_11005	COG0149	triose-phosphate isomerase activity
HG421_11010	COG4221	oxidoreductase activity
HG421_11045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG421_11050	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HG421_11065	COG0133	tryptophan synthase activity
HG421_11075	COG0135	phosphoribosylanthranilate isomerase activity
HG421_11080	COG0101	tRNA pseudouridine synthase activity
HG421_11095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HG421_11100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG421_11105	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HG421_11110	COG2890	protein-(glutamine-N5) methyltransferase activity
HG421_11120	COG0688	phosphatidylethanolamine metabolic process
HG421_11125	COG0741	lytic transglycosylase activity
HG421_11130	COG0433	COG0433 Predicted ATPase
HG421_11145	COG0494	nUDIX hydrolase
HG421_11160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HG421_11190	COG0717	Belongs to the dCTP deaminase family
HG421_11195	COG0489	protein tyrosine kinase activity
HG421_11215	COG3590	peptidase
HG421_11235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG421_11240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG421_11245	COG2311	Membrane
HG421_11250	COG1047	Peptidyl-prolyl cis-trans
HG421_11255	COG0791	NLP P60 protein
HG421_11260	COG0791	NLP P60 protein
HG421_11275	COG1301	dicarboxylic acid transport
HG421_11280	COG1785	Belongs to the alkaline phosphatase family
HG421_11285	COG0037	tRNA processing
HG421_11290	COG1722	exodeoxyribonuclease VII activity
HG421_11295	COG0142	geranyltranstransferase activity
HG421_11300	COG4104	PAAR repeat-containing protein
HG421_11310	COG0312	modulator of DNA gyrase
HG421_11320	COG0312	modulator of DNA gyrase
HG421_11330	COG3164	Protein of unknown function
HG421_11335	COG1530	ribonuclease E activity
HG421_11345	COG2968	Membrane
HG421_11385	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HG421_11400	COG0495	leucyl-tRNA aminoacylation
HG421_11410	COG3118	belongs to the thioredoxin family
HG421_11420	COG2155	Conserved Protein
HG421_11465	COG1132	(ABC) transporter
HG421_11470	COG0475	glutathione-regulated potassium exporter activity
HG421_11480	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HG421_11505	COG1187	pseudouridine synthase activity
HG421_11510	COG5002	protein histidine kinase activity
HG421_11510	COG5001	Diguanylate cyclase
HG421_11620	COG2207	Transcriptional regulator
HG421_11625	COG0735	belongs to the Fur family
HG421_11655	COG4452	Inner membrane protein CreD
HG421_11665	COG2205	protein histidine kinase activity
HG421_11670	COG0745	RESPONSE REGULATOR receiver
HG421_11675	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HG421_11700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HG421_11735	COG0643	Histidine kinase
HG421_11735	COG2198	Histidine kinase
HG421_11740	COG0840	transmembrane signaling receptor activity
HG421_11745	COG0835	chemotaxis
HG421_11755	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HG421_11765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HG421_11770	COG3590	peptidase
HG421_11780	COG0588	phosphoglycerate mutase activity
HG421_11785	COG1515	deoxyribonuclease V activity
HG421_11790	COG1741	Belongs to the pirin family
HG421_11805	COG1741	Belongs to the pirin family
HG421_11815	COG1966	Carbon starvation protein
HG421_11820	COG2879	small protein
HG421_11855	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HG421_11860	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HG421_11865	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HG421_11870	COG2080	2 iron, 2 sulfur cluster binding
HG421_11885	COG1609	Transcriptional regulator
HG421_11895	COG2211	Major facilitator Superfamily
HG421_11900	COG0673	inositol 2-dehydrogenase activity
HG421_11935	COG1196	nuclear chromosome segregation
HG421_11935	COG3264	Mechanosensitive ion channel
HG421_11955	COG0629	single-stranded DNA binding
HG421_11960	COG0142	geranyltranstransferase activity
HG421_11970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HG421_11985	COG0527	aspartate kinase activity
HG421_11990	COG0384	phenazine biosynthesis protein PhzF
HG421_11995	COG0384	phenazine biosynthesis protein PhzF
HG421_12005	COG1764	response to oxidative stress
HG421_12015	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HG421_12020	COG1678	Uncharacterized ACR, COG1678
HG421_12030	COG0519	Catalyzes the synthesis of GMP from XMP
HG421_12055	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HG421_12075	COG4942	peptidase
HG421_12095	COG0693	protein deglycase activity
HG421_12105	COG1959	2 iron, 2 sulfur cluster binding
HG421_12110	COG0719	Fe-S assembly protein
HG421_12115	COG0396	ATPase activity
HG421_12120	COG0719	Fe-S assembly protein
HG421_12125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HG421_12130	COG0456	acetyltransferase
HG421_12135	COG2146	nitrite reductase [NAD(P)H] activity
HG421_12140	COG4774	siderophore transport
HG421_12145	COG3128	pkhd-type hydroxylase
HG421_12170	COG1477	protein flavinylation
HG421_12185	COG1555	photosystem II stabilization
HG421_12200	COG3178	'Phosphotransferase
HG421_12205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HG421_12215	COG0628	permease
HG421_12225	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HG421_12240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HG421_12265	COG0271	Belongs to the BolA IbaG family
HG421_12275	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HG421_12285	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HG421_12290	COG1137	ATPase activity
HG421_12305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HG421_12315	COG1660	Displays ATPase and GTPase activities
HG421_12325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HG421_12330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HG421_12335	COG2239	Acts as a magnesium transporter
HG421_12345	COG1294	oxidase, subunit
HG421_12350	COG1271	oxidase subunit
HG421_12355	COG1113	amino acid transport
HG421_12400	COG2197	response regulator
HG421_12405	COG0531	amino acid
HG421_12420	COG1234	tRNA 3'-trailer cleavage
HG421_12455	COG2814	Major facilitator Superfamily
HG421_12465	COG0754	glutathionylspermidine amidase activity
HG421_12490	COG1842	Phage shock protein A
HG421_12505	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HG421_12510	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HG421_12520	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HG421_12590	COG2814	Major facilitator Superfamily
HG421_12610	COG2205	protein histidine kinase activity
HG421_12610	COG0784	Response regulator, receiver
HG421_12610	COG2198	Histidine kinase
HG421_12615	COG2353	YceI-like domain
HG421_12630	COG1278	Cold shock
HG421_12640	COG1760	l-serine dehydratase
HG421_12650	COG0527	aspartate kinase activity
HG421_12650	COG0460	homoserine dehydrogenase
HG421_12655	COG0626	cystathionine gamma-synthase activity
HG421_12660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HG421_12675	COG1272	protein, Hemolysin III
HG421_12680	COG2982	Protein involved in outer membrane biogenesis
HG421_12685	COG0516	GMP reductase activity
HG421_12685	COG0517	IMP dehydrogenase activity
HG421_12690	COG0463	Glycosyl transferase, family 2
HG421_12695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HG421_12700	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HG421_12715	COG1309	transcriptional regulator
HG421_12725	COG1960	acyl-CoA dehydrogenase activity
HG421_12755	COG0509	glycine decarboxylation via glycine cleavage system
HG421_12760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HG421_12790	COG0494	nUDIX hydrolase
HG421_12800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HG421_12805	COG0837	glucose binding
HG421_12820	COG3858	chitin binding
HG421_12820	COG1388	LysM domain
HG421_12825	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HG421_12835	COG1472	Belongs to the glycosyl hydrolase 3 family
HG421_12845	COG3537	Alpha-1,2-mannosidase
HG421_12895	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HG421_12920	COG3142	Participates in the control of copper homeostasis
HG421_12925	COG1446	asparaginase
HG421_12930	COG2304	oxidoreductase activity
HG421_12950	COG2198	Histidine kinase
HG421_12950	COG0784	Response regulator, receiver
HG421_12950	COG0643	Histidine kinase
HG421_12955	COG0840	transmembrane signaling receptor activity
HG421_12960	COG0835	chemotaxis
HG421_12975	COG0189	ligase activity
HG421_12985	COG1397	ADP-ribosylglycohydrolase
HG421_12995	COG1199	ATP-dependent helicase activity
HG421_13005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HG421_13020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HG421_13030	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HG421_13035	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HG421_13045	COG0535	radical SAM domain protein
HG421_13065	COG0837	glucose binding
HG421_13075	COG1643	Atp-dependent helicase
HG421_13080	COG0783	Belongs to the Dps family
HG421_13085	COG0514	ATP-dependent DNA helicase (RecQ)
HG421_13100	COG1187	pseudouridine synthase activity
HG421_13130	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HG421_13135	COG0602	queuosine metabolic process
HG421_13145	COG2885	chlorophyll binding
HG421_13150	COG0823	Involved in the tonB-independent uptake of proteins
HG421_13160	COG0848	biopolymer transport protein
HG421_13170	COG0824	Thioesterase
HG421_13175	COG2255	four-way junction helicase activity
HG421_13190	COG0632	four-way junction helicase activity
HG421_13195	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HG421_13200	COG0217	transcriptional regulatory protein
HG421_13215	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HG421_13230	COG0477	Major facilitator Superfamily
HG421_13260	COG0488	(ABC) transporter
HG421_13290	COG4651	solute:proton antiporter activity
HG421_13290	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HG421_13315	COG4772	TonB-dependent receptor
HG421_13320	COG1181	Belongs to the D-alanine--D-alanine ligase family
HG421_13325	COG4264	IucA IucC family
HG421_13330	COG2814	Major facilitator Superfamily
HG421_13340	COG0019	diaminopimelate decarboxylase activity
HG421_13360	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HG421_13395	COG4206	TonB-dependent receptor
HG421_13405	COG0542	response to heat
HG421_13410	COG1116	anion transmembrane transporter activity
HG421_13415	COG2827	Endonuclease containing a URI domain
HG421_13475	COG3387	PFAM Glycoside hydrolase 15-related
HG421_13490	COG0840	transmembrane signaling receptor activity
HG421_13495	COG3011	Protein conserved in bacteria
HG421_13510	COG0564	pseudouridine synthase activity
HG421_13515	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG421_13520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG421_13520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HG421_13525	COG2852	Protein conserved in bacteria
HG421_13535	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HG421_13540	COG0045	succinate-CoA ligase (ADP-forming) activity
HG421_13575	COG4969	Belongs to the N-Me-Phe pilin family
HG421_13590	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HG421_13595	COG0237	dephospho-CoA kinase activity
HG421_13640	COG0745	RESPONSE REGULATOR receiver
HG421_13650	COG0189	ligase activity
HG421_13690	COG2022	thiamine diphosphate biosynthetic process
HG421_13700	COG3273	potassium ion transport
HG421_13700	COG0471	metal ion transport
HG421_13720	COG1970	mechanosensitive ion channel activity
HG421_13730	COG1609	Transcriptional regulator
HG421_13735	COG5297	Belongs to the glycosyl hydrolase family 6
HG421_13745	COG3250	beta-galactosidase activity
HG421_13750	COG4948	Mandelate Racemase Muconate Lactonizing
HG421_13760	COG2272	Belongs to the type-B carboxylesterase lipase family
HG421_13765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HG421_13770	COG1115	amino acid carrier protein
HG421_13775	COG0308	aminopeptidase N
HG421_13780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG421_13785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG421_13790	COG2895	sulfate adenylyltransferase (ATP) activity
HG421_13790	COG0529	Catalyzes the synthesis of activated sulfate
HG421_13800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HG421_13805	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HG421_13810	COG0175	sulfate reduction
HG421_13830	COG0784	Response regulator, receiver
HG421_13830	COG2198	Histidine kinase
HG421_13830	COG2205	protein histidine kinase activity
HG421_13835	COG0583	DNA-binding transcription factor activity
HG421_13855	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HG421_13860	COG3588	fructose-bisphosphate aldolase
HG421_13865	COG0469	pyruvate kinase activity
HG421_13905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG421_13930	COG3453	Protein conserved in bacteria
HG421_13930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG421_13935	COG0725	ABC transporter, periplasmic molybdate-binding protein
HG421_13940	COG4149	molybdate abc transporter
HG421_13945	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HG421_13965	COG0642	Histidine kinase
HG421_13970	COG0745	RESPONSE REGULATOR receiver
HG421_13980	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_13990	COG1022	Amp-dependent synthetase and ligase
HG421_14015	COG1376	ErfK ybiS ycfS ynhG family protein
HG421_14020	COG0739	heme binding
HG421_14030	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_14035	COG0583	DNA-binding transcription factor activity
HG421_14040	COG4773	Receptor
HG421_14045	COG3385	transposase activity
HG421_14055	COG1301	dicarboxylic acid transport
HG421_14070	COG2304	oxidoreductase activity
HG421_14090	COG0714	Associated with various cellular activities
HG421_14120	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HG421_14150	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HG421_14175	COG3039	Transposase
HG421_14180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HG421_14195	COG1561	YicC-like family, N-terminal region
HG421_14200	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HG421_14205	COG0346	lactoylglutathione lyase activity
HG421_14215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG421_14240	COG0006	proline dipeptidase activity
HG421_14245	COG0006	proline dipeptidase activity
HG421_14250	COG3079	Belongs to the UPF0149 family
HG421_14270	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HG421_14290	COG2912	Transglutaminase-like superfamily
HG421_14295	COG1773	rubredoxin
HG421_14300	COG0352	thiamine-phosphate diphosphorylase activity
HG421_14310	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HG421_14325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HG421_14360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HG421_14375	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_14385	COG0671	phosphoesterase, PA-phosphatase related
HG421_14390	COG3781	membrane
HG421_14400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HG421_14405	COG0563	adenylate kinase activity
HG421_14430	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HG421_14440	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HG421_14460	COG3710	Transcriptional regulator
HG421_14465	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HG421_14470	COG1506	peptidase
HG421_14470	COG4946	Tricorn protease homolog
HG421_14470	COG0823	Involved in the tonB-independent uptake of proteins
HG421_14475	COG0840	transmembrane signaling receptor activity
HG421_14480	COG0405	Gamma-glutamyltransferase
HG421_14485	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HG421_14505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG421_14515	COG0473	3-isopropylmalate dehydrogenase activity
HG421_14520	COG0066	3-isopropylmalate dehydratase activity
HG421_14525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HG421_14545	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HG421_14550	COG1538	Outer membrane efflux protein
HG421_14555	COG1519	Transferase
HG421_14560	COG1560	Kdo2-lipid A biosynthetic process
HG421_14600	COG0281	malic enzyme
HG421_14600	COG0280	phosphate acetyltransferase
HG421_14620	COG4191	Histidine kinase
HG421_14630	COG0667	Aldo Keto reductase
HG421_14640	COG2197	response regulator
HG421_14650	COG0642	Histidine kinase
HG421_14665	COG2851	Citrate transporter
HG421_14670	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_14675	COG1609	Transcriptional regulator
HG421_14680	COG2211	Major facilitator Superfamily
HG421_14705	COG1162	GTPase activity
HG421_14710	COG0436	Aminotransferase
HG421_14730	COG0726	polysaccharide deacetylase
HG421_14735	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HG421_14745	COG3964	amidohydrolase
HG421_14750	COG0402	S-adenosylhomocysteine deaminase activity
HG421_14775	COG1307	EDD domain protein, DegV family
HG421_14785	COG0697	spore germination
HG421_14795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HG421_14805	COG3791	Glutathione-dependent formaldehyde-activating
HG421_14820	COG0583	DNA-binding transcription factor activity
HG421_14835	COG0745	RESPONSE REGULATOR receiver
HG421_14840	COG2205	protein histidine kinase activity
HG421_14855	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HG421_14870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HG421_14880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HG421_14885	COG1012	belongs to the aldehyde dehydrogenase family
HG421_14890	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HG421_14920	COG1183	phosphatidylcholine synthase activity
HG421_14930	COG0442	prolyl-tRNA aminoacylation
HG421_14945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HG421_14950	COG1127	ABC transporter
HG421_14955	COG3218	ABC-type transport auxiliary lipoprotein component
HG421_14955	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HG421_14985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG421_15020	COG2086	electron transfer activity
HG421_15035	COG0463	Glycosyl transferase, family 2
HG421_15060	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HG421_15065	COG0438	transferase activity, transferring glycosyl groups
HG421_15085	COG0438	transferase activity, transferring glycosyl groups
HG421_15090	COG0626	cystathionine gamma-synthase activity
HG421_15120	COG0625	glutathione transferase activity
HG421_15135	COG0513	Belongs to the DEAD box helicase family
HG421_15140	COG0720	synthase
HG421_15150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HG421_15155	COG1956	GAF domain-containing protein
HG421_15165	COG0546	phosphoglycolate phosphatase activity
HG421_15170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HG421_15175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HG421_15220	COG0339	signal peptide processing
HG421_15225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HG421_15260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HG421_15270	COG1136	(ABC) transporter
HG421_15280	COG0577	efflux transmembrane transporter activity
HG421_15280	COG1136	(ABC) transporter
HG421_15295	COG4191	Histidine kinase
HG421_15300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HG421_15315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HG421_15320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HG421_15325	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HG421_15335	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HG421_15340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HG421_15350	COG0356	it plays a direct role in the translocation of protons across the membrane
HG421_15365	COG1228	amidohydrolase
HG421_15370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG421_15380	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG421_15405	COG1464	Belongs to the NlpA lipoprotein family
HG421_15410	COG2011	ABC-type metal ion transport system permease component
HG421_15415	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HG421_15420	COG0697	spore germination
HG421_15425	COG1666	GTP binding
HG421_15455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HG421_15460	COG1187	pseudouridine synthase activity
HG421_15465	COG2813	Specifically methylates the guanine in position
HG421_15485	COG2205	protein histidine kinase activity
HG421_15485	COG2202	Pas domain
HG421_15510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG421_15555	COG4191	Histidine kinase
HG421_15555	COG0784	Response regulator, receiver
HG421_15565	COG1404	Belongs to the peptidase S8 family
HG421_15580	COG0842	Transport permease protein
HG421_15585	COG1131	(ABC) transporter
HG421_15590	COG0025	NhaP-type Na H and K H
HG421_15595	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HG421_15600	COG1573	uracil-dna glycosylase
HG421_15610	COG3384	dioxygenase
HG421_15625	COG0667	Aldo Keto reductase
HG421_15635	COG3590	peptidase
HG421_15650	COG0531	amino acid
HG421_15665	COG2972	Histidine kinase
HG421_15680	COG3685	Protein conserved in bacteria
HG421_15685	COG3546	catalase activity
HG421_15710	COG2204	response regulator
HG421_15720	COG1271	oxidase subunit
HG421_15725	COG1294	oxidase, subunit
HG421_15740	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_15750	COG1063	alcohol dehydrogenase
HG421_15825	COG0038	chloride channel
HG421_15830	COG0583	DNA-binding transcription factor activity
HG421_15835	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_15840	COG1335	isochorismatase
HG421_15885	COG4251	negative regulation of phosphorylation
HG421_15890	COG0784	Response regulator, receiver
HG421_16055	COG0582	viral genome integration into host DNA
HG421_16070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG421_16075	COG1490	D-aminoacyl-tRNA deacylase activity
HG421_16085	COG1247	-acetyltransferase
HG421_16090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG421_16125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HG421_16125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HG421_16130	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HG421_16135	COG0242	peptide deformylase activity
HG421_16140	COG1652	LysM domain
HG421_16145	COG0758	DNA mediated transformation
HG421_16165	COG1754	DNA topoisomerase type I activity
HG421_16165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG421_16170	COG0009	L-threonylcarbamoyladenylate synthase
HG421_16185	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_16195	COG0616	signal peptide processing
HG421_16200	COG0534	Mate efflux family protein
HG421_16220	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HG421_16225	COG0625	glutathione transferase activity
HG421_16240	COG1252	NADH dehydrogenase
HG421_16245	COG2860	membrane
HG421_16250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG421_16255	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HG421_16260	COG2201	protein-glutamate methylesterase activity
HG421_16265	COG2177	Part of the ABC transporter FtsEX involved in
HG421_16270	COG2884	Cell division ATP-binding protein ftsE
HG421_16280	COG3118	belongs to the thioredoxin family
HG421_16285	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HG421_16290	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HG421_16295	COG0583	DNA-binding transcription factor activity
HG421_16340	COG1518	maintenance of DNA repeat elements
HG421_16345	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HG421_16360	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HG421_16360	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HG421_16365	COG1473	amidohydrolase
HG421_16370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG421_16375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG421_16385	COG5383	Protein conserved in bacteria
HG421_16425	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HG421_16430	COG3023	N-Acetylmuramoyl-L-alanine amidase
HG421_16440	COG4948	Mandelate Racemase Muconate Lactonizing
HG421_16450	COG0531	amino acid
HG421_16465	COG4682	membrane
HG421_16470	COG2133	pyrroloquinoline quinone binding
HG421_16480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HG421_16485	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HG421_16495	COG1610	YqeY-like protein
HG421_16500	COG1295	ribonuclease BN
HG421_16505	COG0358	DNA primase activity
HG421_16525	COG0109	protoheme IX farnesyltransferase activity
HG421_16555	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HG421_16565	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HG421_16610	COG0739	heme binding
HG421_16625	COG2211	Major facilitator Superfamily
HG421_16630	COG0708	Exodeoxyribonuclease III
HG421_16645	COG1192	Involved in chromosome partitioning
HG421_16650	COG1475	DNA binding
HG421_16665	COG0463	Glycosyl transferase, family 2
HG421_16685	COG0756	dUTP diphosphatase activity
HG421_16690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HG421_16700	COG0018	arginyl-trna synthetase
HG421_16715	COG4221	oxidoreductase activity
HG421_16720	COG2755	lipolytic protein G-D-S-L family
HG421_16720	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HG421_16730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HG421_16740	COG1166	arginine decarboxylase activity
HG421_16745	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HG421_16760	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HG421_16760	COG3291	Pkd domain containing protein
HG421_16770	COG2960	long-chain fatty acid transporting porin activity
HG421_16775	COG0606	chelatase, subunit chli
HG421_16815	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HG421_16865	COG1090	epimerase
HG421_16880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG421_16910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HG421_16915	COG0753	catalase activity
HG421_16930	COG2197	response regulator
HG421_16935	COG4585	Histidine kinase
HG421_16940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG421_16945	COG1136	(ABC) transporter
HG421_16970	COG0697	spore germination
HG421_16990	COG0180	Tryptophanyl-tRNA synthetase
HG421_16995	COG3237	CsbD-like
HG421_17035	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HG421_17050	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HG421_17055	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HG421_17055	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HG421_17080	COG2205	protein histidine kinase activity
HG421_17085	COG0745	RESPONSE REGULATOR receiver
HG421_17095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG421_17170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG421_17200	COG1199	ATP-dependent helicase activity
HG421_17210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HG421_17260	COG0625	glutathione transferase activity
HG421_17305	COG4555	ABC transporter
HG421_17315	COG1476	TRANSCRIPTIONal
HG421_17360	COG0633	Ferredoxin
HG421_17360	COG0543	2 iron, 2 sulfur cluster binding
HG421_17365	COG1131	(ABC) transporter
HG421_17370	COG0842	Transport permease protein
HG421_17375	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HG421_17395	COG1607	acyl-coa hydrolase
HG421_17415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG421_17420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG421_17430	COG0045	succinate-CoA ligase (ADP-forming) activity
HG421_17430	COG1042	CoA-binding domain protein
HG421_17430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HG421_17435	COG2239	Acts as a magnesium transporter
HG421_17445	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HG421_17450	COG3387	PFAM Glycoside hydrolase 15-related
HG421_17465	COG3100	YcgL domain-containing protein
HG421_17470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG421_17480	COG0463	Glycosyl transferase, family 2
HG421_17495	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_17520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HG421_17535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HG421_17540	COG0644	oxidoreductase
HG421_17560	COG3385	transposase activity
HG421_17595	COG1121	(ABC) transporter
HG421_17630	COG0408	coproporphyrinogen oxidase activity
HG421_17635	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG421_17635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG421_17660	COG0515	serine threonine protein kinase
HG421_17665	COG0631	protein serine/threonine phosphatase activity
HG421_17710	COG3501	Rhs element vgr protein
HG421_17725	COG2815	serine threonine protein kinase
HG421_17725	COG0515	serine threonine protein kinase
HG421_17835	COG0210	DNA helicase
HG421_17845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HG421_17855	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HG421_17865	COG2159	amidohydrolase
HG421_17910	COG0357	Ribosomal RNA small subunit methyltransferase G
HG421_17920	COG2091	lysine biosynthetic process via aminoadipic acid
HG421_17945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG421_18010	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_18015	COG0179	Fumarylacetoacetate (FAA) hydrolase
HG421_18020	COG4948	Mandelate Racemase Muconate Lactonizing
HG421_18025	COG3254	rhamnose metabolic process
HG421_18030	COG0738	Major facilitator superfamily
HG421_18035	COG1414	Transcriptional regulator
HG421_18040	COG1971	Probably functions as a manganese efflux pump
HG421_18045	COG2205	protein histidine kinase activity
HG421_18045	COG0784	Response regulator, receiver
HG421_18050	COG3459	Glycosyltransferase 36 associated
HG421_18055	COG2211	Major facilitator Superfamily
HG421_18060	COG3265	gluconokinase activity
HG421_18065	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG421_18090	COG0443	Heat shock 70 kDa protein
HG421_18100	COG2911	Protein conserved in bacteria
HG421_18105	COG0729	surface antigen
HG421_18110	COG4771	TonB-dependent receptor
HG421_18115	COG0457	Tetratricopeptide repeat
HG421_18125	COG0752	glycyl-tRNA synthetase alpha subunit
HG421_18130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HG421_18135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HG421_18135	COG0519	Catalyzes the synthesis of GMP from XMP
HG421_18145	COG0805	protein transport
HG421_18150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HG421_18155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HG421_18170	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HG421_18175	COG0596	Alpha beta hydrolase
HG421_18185	COG2974	May be involved in recombination
HG421_18190	COG0037	tRNA processing
HG421_18195	COG2115	Belongs to the xylose isomerase family
HG421_18205	COG3661	Belongs to the glycosyl hydrolase 67 family
HG421_18215	COG4948	Mandelate Racemase Muconate Lactonizing
HG421_18225	COG1472	Belongs to the glycosyl hydrolase 3 family
HG421_18230	COG0246	Mannitol dehydrogenase
HG421_18270	COG3386	PFAM SMP-30 Gluconolaconase
HG421_18290	COG1904	glucuronate isomerase
HG421_18295	COG3693	PFAM glycoside hydrolase, family 10
HG421_18310	COG2211	Major facilitator Superfamily
HG421_18350	COG2937	Belongs to the GPAT DAPAT family
HG421_18385	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HG421_18390	COG3132	Protein of unknown function, DUF480
HG421_18395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HG421_18400	COG0210	DNA helicase
HG421_18405	COG1435	thymidine kinase activity
HG421_18415	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HG421_18425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HG421_18455	COG3135	benzoate transporter
HG421_18475	COG0676	glucose-6-phosphate 1-epimerase activity
HG421_18490	COG0730	response to heat
HG421_18520	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HG421_18525	COG0302	gtp cyclohydrolase
HG421_18540	COG1566	PFAM secretion protein HlyD family protein
HG421_18550	COG1289	transmembrane transporter activity
HG421_18555	COG0477	Major facilitator Superfamily
HG421_18560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HG421_18580	COG3550	peptidyl-serine autophosphorylation
HG421_18620	COG0564	pseudouridine synthase activity
HG421_18690	COG3549	Plasmid maintenance system killer
HG421_18700	COG1074	ATP-dependent DNA helicase activity
HG421_18705	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HG421_18740	COG1127	ABC transporter
HG421_18745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HG421_18750	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HG421_18765	COG2853	Lipoprotein
HG421_18775	COG0386	Belongs to the glutathione peroxidase family
HG421_18810	COG0531	amino acid
HG421_18815	COG3537	Alpha-1,2-mannosidase
HG421_18825	COG3706	GGDEF domain
HG421_18830	COG1929	Belongs to the glycerate kinase type-1 family
HG421_18855	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HG421_18860	COG0861	Integral membrane protein TerC family
HG421_18870	COG0584	glycerophosphoryl diester phosphodiesterase
HG421_18890	COG0706	membrane insertase activity
HG421_18915	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HG421_18930	COG0501	Belongs to the peptidase M48B family
HG421_18965	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HG421_18975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HG421_19010	COG0793	Belongs to the peptidase S41A family
HG421_19015	COG4942	peptidase
HG421_19025	COG2234	aminopeptidase activity
HG421_19035	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HG421_19040	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HG421_19045	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HG421_19050	COG1064	alcohol dehydrogenase
HG421_19055	COG0493	'glutamate synthase
HG421_19060	COG0067	glutamate synthase
HG421_19060	COG0070	glutamate synthase
HG421_19060	COG0069	glutamate synthase activity
HG421_19120	COG1205	dead DEAH box helicase
HG421_19120	COG1111	helicase
HG421_19125	COG1272	protein, Hemolysin III
HG421_19150	COG0625	glutathione transferase activity
HG421_19160	COG0583	DNA-binding transcription factor activity
HG421_19165	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_19255	COG0628	permease
HG421_19265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG421_19270	COG0477	Major facilitator Superfamily
HG421_19315	COG0714	Associated with various cellular activities
HG421_19370	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HG421_19380	COG4772	TonB-dependent receptor
HG421_19385	COG1012	belongs to the aldehyde dehydrogenase family
HG421_19435	COG1755	Isoprenylcysteine carboxyl methyltransferase
HG421_19440	COG4585	Histidine kinase
HG421_19445	COG2197	response regulator
HG421_19460	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HG421_19575	COG0366	Alpha amylase catalytic
HG421_19580	COG0366	Alpha amylase catalytic
HG421_19615	COG2755	lipolytic protein G-D-S-L family
HG421_19625	COG2755	lipolytic protein G-D-S-L family
HG421_19625	COG0657	acetylesterase activity
HG421_19635	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HG421_19650	COG3507	Belongs to the glycosyl hydrolase 43 family
HG421_19655	COG1609	Transcriptional regulator
HG421_19660	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HG421_19665	COG1028	Short-chain dehydrogenase reductase Sdr
HG421_19675	COG2755	lipolytic protein G-D-S-L family
HG421_19685	COG3186	Phenylalanine-4-hydroxylase
HG421_19690	COG1522	sequence-specific DNA binding
HG421_19695	COG1752	Esterase of the alpha-beta hydrolase superfamily
HG421_19705	COG1119	ATPase activity
HG421_19715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HG421_19720	COG1125	glycine betaine transport
HG421_19735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HG421_19740	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HG421_19750	COG3550	peptidyl-serine autophosphorylation
HG421_19755	COG1396	sequence-specific DNA binding
HG421_19790	COG0489	protein tyrosine kinase activity
HG421_19795	COG2062	phosphohistidine phosphatase, SixA
HG421_19805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HG421_19850	COG0174	glutamine synthetase
HG421_19855	COG0347	Belongs to the P(II) protein family
HG421_19860	COG0004	ammonium transporteR
HG421_19865	COG3852	Histidine kinase
HG421_19870	COG2204	response regulator
HG421_19875	COG2032	superoxide dismutase activity
HG421_19880	COG2032	superoxide dismutase activity
HG421_19885	COG0346	lactoylglutathione lyase activity
HG421_19895	COG0183	Belongs to the thiolase family
HG421_19935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HG421_19940	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HG421_19945	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HG421_20005	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG421_20010	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG421_20015	COG4786	Flagellar basal body rod
HG421_20020	COG4786	Flagellar basal body rod
HG421_20035	COG1706	bacterial-type flagellum-dependent cell motility
HG421_20050	COG1677	Flagellar hook-basal body complex protein FliE
HG421_20055	COG1766	The M ring may be actively involved in energy transduction
HG421_20070	COG1157	protein secretion by the type III secretion system
HG421_20085	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HG421_20090	COG1749	Flagellar hook protein flgE
HG421_20120	COG0028	Belongs to the TPP enzyme family
HG421_20125	COG2205	protein histidine kinase activity
HG421_20150	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HG421_20165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HG421_20170	COG3177	Filamentation induced by cAMP protein fic
HG421_20175	COG0596	Alpha beta hydrolase
HG421_20180	COG0727	PFAM Uncharacterised protein family (UPF0153)
HG421_20185	COG0318	PFAM AMP-dependent synthetase and ligase
HG421_20190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG421_20205	COG1181	Belongs to the D-alanine--D-alanine ligase family
HG421_20215	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HG421_20220	COG0564	pseudouridine synthase activity
HG421_20245	COG1446	asparaginase
HG421_20250	COG0339	signal peptide processing
HG421_20310	COG0583	DNA-binding transcription factor activity
HG421_20315	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HG421_20320	COG2224	Isocitrate lyase
HG421_20325	COG3706	GGDEF domain
HG421_20350	COG4770	biotin carboxylase activity
HG421_20355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HG421_20360	COG1960	acyl-CoA dehydrogenase activity
HG421_20430	COG0697	spore germination
HG421_20440	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HG421_20445	COG1846	Transcriptional regulator
HG421_20450	COG1764	response to oxidative stress
HG421_20465	COG0656	L-ascorbic acid biosynthetic process
HG421_20470	COG2130	NADP-dependent
HG421_20475	COG0667	Aldo Keto reductase
HG421_20485	COG1187	pseudouridine synthase activity
HG421_20495	COG1643	Atp-dependent helicase
HG421_20500	COG4807	Protein conserved in bacteria
HG421_20505	COG2351	hydroxyisourate hydrolase activity
HG421_20510	COG2072	flavoprotein involved in K transport
HG421_20530	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HG421_20570	COG2252	PERMEase
HG421_20605	COG0084	hydrolase, TatD family'
HG421_20620	COG0583	DNA-binding transcription factor activity
HG421_20625	COG2814	Major facilitator Superfamily
HG421_20635	COG1902	pentaerythritol trinitrate reductase activity
HG421_20660	COG1472	Belongs to the glycosyl hydrolase 3 family
HG421_20675	COG0583	DNA-binding transcription factor activity
HG421_20700	COG0702	epimerase
HG421_20705	COG1733	regulation of RNA biosynthetic process
HG421_20760	COG0129	dihydroxy-acid dehydratase activity
HG421_20775	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HG421_20825	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HG421_20830	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HG421_20860	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HG421_20865	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HG421_20875	COG3485	protocatechuate 3,4-dioxygenase
HG421_20880	COG3485	protocatechuate 3,4-dioxygenase
HG421_20885	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HG421_20890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HG421_20895	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HG421_20905	COG1414	Transcriptional regulator
HG421_20935	COG0445	tRNA wobble uridine modification
HG421_20940	COG3385	transposase activity
HG421_20950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HG421_20990	COG0156	8-amino-7-oxononanoate synthase activity
HG421_20995	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HG421_21000	COG1040	competence protein
HG421_21005	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HG421_21020	COG3264	Mechanosensitive ion channel
HG421_21020	COG1511	domain protein