locus-tag	class	description
OF401_00020	COG0187	DNA topoisomerase II activity
OF401_00030	COG0501	Belongs to the peptidase M48B family
OF401_00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OF401_00105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OF401_00110	COG0793	Belongs to the peptidase S41A family
OF401_00115	COG4942	peptidase
OF401_00125	COG2234	aminopeptidase activity
OF401_00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
OF401_00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
OF401_00150	COG3039	Transposase
OF401_00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
OF401_00160	COG1064	alcohol dehydrogenase
OF401_00175	COG0493	'glutamate synthase
OF401_00180	COG0070	glutamate synthase
OF401_00180	COG0069	glutamate synthase activity
OF401_00180	COG0067	glutamate synthase
OF401_00205	COG1741	Belongs to the pirin family
OF401_00210	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OF401_00230	COG0583	DNA-binding transcription factor activity
OF401_00290	COG1205	dead DEAH box helicase
OF401_00290	COG1111	helicase
OF401_00295	COG1272	protein, Hemolysin III
OF401_00315	COG2249	NAD(P)H dehydrogenase (quinone) activity
OF401_00325	COG1733	regulation of RNA biosynthetic process
OF401_00340	COG0457	Tetratricopeptide repeat
OF401_00375	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
OF401_00380	COG3237	CsbD-like
OF401_00440	COG0628	permease
OF401_00445	COG0657	acetylesterase activity
OF401_00455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OF401_00460	COG0477	Major facilitator Superfamily
OF401_00500	COG0714	Associated with various cellular activities
OF401_00540	COG4772	TonB-dependent receptor
OF401_00555	COG1012	belongs to the aldehyde dehydrogenase family
OF401_00620	COG3710	Transcriptional regulator
OF401_00640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OF401_00750	COG0366	Alpha amylase catalytic
OF401_00755	COG0366	Alpha amylase catalytic
OF401_00805	COG2755	lipolytic protein G-D-S-L family
OF401_00815	COG0657	acetylesterase activity
OF401_00815	COG2755	lipolytic protein G-D-S-L family
OF401_00825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OF401_00840	COG3507	Belongs to the glycosyl hydrolase 43 family
OF401_00845	COG1609	Transcriptional regulator
OF401_00855	COG1028	Short-chain dehydrogenase reductase Sdr
OF401_00865	COG2755	lipolytic protein G-D-S-L family
OF401_00875	COG3186	Phenylalanine-4-hydroxylase
OF401_00880	COG1522	sequence-specific DNA binding
OF401_00890	COG1752	Esterase of the alpha-beta hydrolase superfamily
OF401_00900	COG1119	ATPase activity
OF401_00915	COG0517	IMP dehydrogenase activity
OF401_00915	COG1125	glycine betaine transport
OF401_00930	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OF401_00935	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
OF401_00965	COG0489	protein tyrosine kinase activity
OF401_00970	COG0588	phosphoglycerate mutase activity
OF401_00980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OF401_01005	COG1881	PFAM PEBP family protein
OF401_01020	COG0174	glutamine synthetase
OF401_01025	COG0347	Belongs to the P(II) protein family
OF401_01030	COG0004	ammonium transporteR
OF401_01035	COG3852	Histidine kinase
OF401_01040	COG2204	response regulator
OF401_01045	COG2032	superoxide dismutase activity
OF401_01050	COG2032	superoxide dismutase activity
OF401_01055	COG0346	lactoylglutathione lyase activity
OF401_01065	COG0183	Belongs to the thiolase family
OF401_01105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OF401_01125	COG0028	Belongs to the TPP enzyme family
OF401_01140	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OF401_01155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OF401_01160	COG3177	Filamentation induced by cAMP protein fic
OF401_01165	COG0596	Alpha beta hydrolase
OF401_01170	COG0727	PFAM Uncharacterised protein family (UPF0153)
OF401_01180	COG0318	PFAM AMP-dependent synthetase and ligase
OF401_01185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OF401_01200	COG1181	Belongs to the D-alanine--D-alanine ligase family
OF401_01215	COG0564	pseudouridine synthase activity
OF401_01235	COG1446	asparaginase
OF401_01240	COG0339	signal peptide processing
OF401_01270	COG0583	DNA-binding transcription factor activity
OF401_01275	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OF401_01280	COG2224	Isocitrate lyase
OF401_01310	COG4770	biotin carboxylase activity
OF401_01315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OF401_01320	COG1960	acyl-CoA dehydrogenase activity
OF401_01385	COG0697	spore germination
OF401_01395	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
OF401_01405	COG1846	Transcriptional regulator
OF401_01410	COG1764	response to oxidative stress
OF401_01440	COG0656	L-ascorbic acid biosynthetic process
OF401_01445	COG2130	NADP-dependent
OF401_01460	COG1187	pseudouridine synthase activity
OF401_01470	COG1643	Atp-dependent helicase
OF401_01475	COG0840	transmembrane signaling receptor activity
OF401_01480	COG4807	Protein conserved in bacteria
OF401_01485	COG2351	hydroxyisourate hydrolase activity
OF401_01490	COG2072	flavoprotein involved in K transport
OF401_01510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OF401_01535	COG3568	Endonuclease Exonuclease Phosphatase
OF401_01540	COG3568	Endonuclease Exonuclease Phosphatase
OF401_01545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OF401_01560	COG1957	nucleoside hydrolase
OF401_01570	COG2252	PERMEase
OF401_01590	COG0084	hydrolase, TatD family'
OF401_01600	COG0583	DNA-binding transcription factor activity
OF401_01605	COG2814	Major facilitator Superfamily
OF401_01625	COG1902	pentaerythritol trinitrate reductase activity
OF401_01650	COG0300	oxidoreductase activity
OF401_01660	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OF401_01665	COG0583	DNA-binding transcription factor activity
OF401_01695	COG0702	epimerase
OF401_01700	COG1733	regulation of RNA biosynthetic process
OF401_01710	COG0840	transmembrane signaling receptor activity
OF401_01795	COG3039	Transposase
OF401_01850	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OF401_01910	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OF401_01935	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OF401_01940	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OF401_01950	COG3485	protocatechuate 3,4-dioxygenase
OF401_01955	COG3485	protocatechuate 3,4-dioxygenase
OF401_01965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OF401_01970	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OF401_01980	COG1414	Transcriptional regulator
OF401_01990	COG0657	acetylesterase activity
OF401_02010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OF401_02060	COG1040	competence protein
OF401_02075	COG0582	viral genome integration into host DNA
OF401_02085	COG4774	siderophore transport
OF401_02090	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OF401_02105	COG4206	TonB-dependent receptor
OF401_02125	COG1511	domain protein
OF401_02125	COG3264	Mechanosensitive ion channel
OF401_02140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OF401_02145	COG2354	Protein conserved in bacteria
OF401_02150	COG1649	PFAM Uncharacterised BCR, COG1649
OF401_02160	COG0297	glycogen (starch) synthase activity
OF401_02170	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OF401_02195	COG0702	epimerase
OF401_02230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OF401_02235	COG2085	NADP oxidoreductase coenzyme F420-dependent
OF401_02250	COG0513	Belongs to the DEAD box helicase family
OF401_02260	COG0508	dehydrogenase complex catalyzes the overall conversion of
OF401_02275	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OF401_02290	COG3104	oligopeptide transport
OF401_02310	COG2852	Protein conserved in bacteria
OF401_02335	COG1320	monovalent cation:proton antiporter activity
OF401_02340	COG2212	antiporter activity
OF401_02350	COG0651	ATP synthesis coupled electron transport
OF401_02355	COG1006	Multisubunit Na H antiporter MnhC subunit
OF401_02360	COG2111	Na H antiporter
OF401_02360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OF401_02435	COG0436	Aminotransferase
OF401_02450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OF401_02555	COG2816	NAD+ diphosphatase activity
OF401_02560	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
OF401_02590	COG2814	Major facilitator Superfamily
OF401_02600	COG1289	transmembrane transporter activity
OF401_02605	COG0151	Belongs to the GarS family
OF401_02620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OF401_02625	COG2267	carboxylic ester hydrolase activity
OF401_02630	COG0671	phosphoesterase, PA-phosphatase related
OF401_02630	COG2453	phosphatase
OF401_02655	COG4589	Belongs to the CDS family
OF401_02670	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
OF401_02705	COG0439	Biotin carboxylase
OF401_02715	COG0511	ligase activity, forming carbon-carbon bonds
OF401_02730	COG1324	tolerance protein
OF401_02735	COG2356	endonuclease I
OF401_02750	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
OF401_02760	COG1196	nuclear chromosome segregation
OF401_02805	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OF401_02830	COG3386	PFAM SMP-30 Gluconolaconase
OF401_02845	COG3712	iron ion homeostasis
OF401_02885	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
OF401_02910	COG2353	YceI-like domain
OF401_02965	COG1802	Transcriptional regulator
OF401_03030	COG3039	Transposase
OF401_03100	COG3039	Transposase
OF401_03135	COG0435	Glutathione S-transferase
OF401_03195	COG2409	Drug exporters of the RND superfamily
OF401_03205	COG0823	Involved in the tonB-independent uptake of proteins
OF401_03205	COG1506	peptidase
OF401_03250	COG0697	spore germination
OF401_03265	COG3039	Transposase
OF401_03270	COG4305	rare lipoprotein A
OF401_03275	COG5297	Belongs to the glycosyl hydrolase family 6
OF401_03285	COG1113	amino acid transport
OF401_03345	COG0840	transmembrane signaling receptor activity
OF401_03350	COG5297	Belongs to the glycosyl hydrolase family 6
OF401_03350	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
OF401_03355	COG0659	secondary active sulfate transmembrane transporter activity
OF401_03360	COG3706	GGDEF domain
OF401_03375	COG3273	potassium ion transport
OF401_03375	COG0471	metal ion transport
OF401_03390	COG3275	phosphorelay sensor kinase activity
OF401_03430	COG1505	serine-type exopeptidase activity
OF401_03445	COG0436	Aminotransferase
OF401_03455	COG2832	Protein of unknown function (DUF454)
OF401_03515	COG2226	methyltransferase
OF401_03520	COG5001	Diguanylate cyclase
OF401_03520	COG3300	MHYT domain
OF401_03525	COG0308	aminopeptidase N
OF401_03560	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
OF401_03570	COG3284	Transcriptional regulator
OF401_03575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OF401_03580	COG1077	Cell shape determining protein MreB Mrl
OF401_03590	COG1792	Involved in formation and maintenance of cell shape
OF401_03605	COG0772	Belongs to the SEDS family
OF401_03640	COG2951	lytic endotransglycosylase activity
OF401_03645	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OF401_03650	COG1686	Belongs to the peptidase S11 family
OF401_03700	COG1051	belongs to the nudix hydrolase family
OF401_03700	COG1056	cytidyltransferase-related domain
OF401_03735	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
OF401_03740	COG0673	inositol 2-dehydrogenase activity
OF401_03745	COG2823	Periplasmic or secreted lipoprotein
OF401_03755	COG4251	negative regulation of phosphorylation
OF401_03760	COG0784	Response regulator, receiver
OF401_03765	COG4191	Histidine kinase
OF401_03770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OF401_03775	COG1028	Short-chain dehydrogenase reductase Sdr
OF401_03820	COG1459	type II secretion system
OF401_03835	COG2165	general secretion pathway protein
OF401_03840	COG4795	General secretion pathway protein
OF401_03865	COG2188	Transcriptional regulator
OF401_03875	COG1609	Transcriptional regulator
OF401_03880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OF401_03885	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OF401_03930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OF401_03940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OF401_03965	COG2205	protein histidine kinase activity
OF401_03985	COG0583	DNA-binding transcription factor activity
OF401_04005	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
OF401_04015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OF401_04025	COG0697	spore germination
OF401_04035	COG1307	EDD domain protein, DegV family
OF401_04075	COG0402	S-adenosylhomocysteine deaminase activity
OF401_04095	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OF401_04115	COG0436	Aminotransferase
OF401_04150	COG2211	Major facilitator Superfamily
OF401_04155	COG1609	Transcriptional regulator
OF401_04160	COG1028	Short-chain dehydrogenase reductase Sdr
OF401_04165	COG2851	Citrate transporter
OF401_04180	COG0642	Histidine kinase
OF401_04190	COG2197	response regulator
OF401_04205	COG4191	Histidine kinase
OF401_04245	COG1560	Kdo2-lipid A biosynthetic process
OF401_04250	COG1519	Transferase
OF401_04255	COG1538	Outer membrane efflux protein
OF401_04260	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OF401_04280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
OF401_04290	COG2226	methyltransferase
OF401_04325	COG0405	Gamma-glutamyltransferase
OF401_04330	COG0840	transmembrane signaling receptor activity
OF401_04335	COG1506	peptidase
OF401_04335	COG4946	Tricorn protease homolog
OF401_04335	COG0823	Involved in the tonB-independent uptake of proteins
OF401_04345	COG3710	Transcriptional regulator
OF401_04365	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
OF401_04375	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
OF401_04410	COG3039	Transposase
OF401_04460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OF401_04470	COG3781	membrane
OF401_04475	COG0671	phosphoesterase, PA-phosphatase related
OF401_04485	COG1028	Short-chain dehydrogenase reductase Sdr
OF401_04495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OF401_04500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OF401_04530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OF401_04560	COG1773	rubredoxin
OF401_04565	COG2912	Transglutaminase-like superfamily
OF401_04585	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OF401_04610	COG0006	proline dipeptidase activity
OF401_04635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OF401_04645	COG0346	lactoylglutathione lyase activity
OF401_04655	COG1561	YicC-like family, N-terminal region
OF401_04670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OF401_04680	COG0583	DNA-binding transcription factor activity
OF401_04695	COG2271	Major facilitator Superfamily
OF401_04710	COG2721	sulfolactate sulfo-lyase activity
OF401_04720	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OF401_04750	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
OF401_04780	COG0714	Associated with various cellular activities
OF401_04800	COG2304	oxidoreductase activity
OF401_04810	COG1301	dicarboxylic acid transport
OF401_04815	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OF401_04820	COG0596	Alpha beta hydrolase
OF401_04830	COG0583	DNA-binding transcription factor activity
OF401_04835	COG1028	Short-chain dehydrogenase reductase Sdr
OF401_04840	COG0739	heme binding
OF401_04845	COG1376	ErfK ybiS ycfS ynhG family protein
OF401_04890	COG4149	molybdate abc transporter
OF401_04895	COG0725	ABC transporter, periplasmic molybdate-binding protein
OF401_04915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OF401_04915	COG3453	Protein conserved in bacteria
OF401_04925	COG3039	Transposase
OF401_04935	COG3047	cAMP biosynthetic process
OF401_04950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OF401_04980	COG0469	pyruvate kinase activity
OF401_04985	COG3588	fructose-bisphosphate aldolase
OF401_04990	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
OF401_05025	COG0784	Response regulator, receiver
OF401_05025	COG2198	Histidine kinase
OF401_05025	COG2205	protein histidine kinase activity
OF401_05055	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OF401_05065	COG2895	sulfate adenylyltransferase (ATP) activity
OF401_05065	COG0529	Catalyzes the synthesis of activated sulfate
OF401_05075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OF401_05080	COG0308	aminopeptidase N
OF401_05090	COG1115	amino acid carrier protein
OF401_05095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OF401_05105	COG4948	Mandelate Racemase Muconate Lactonizing
OF401_05125	COG1609	Transcriptional regulator
OF401_05155	COG3273	potassium ion transport
OF401_05155	COG0471	metal ion transport
OF401_05185	COG0582	viral genome integration into host DNA
OF401_05205	COG1396	sequence-specific DNA binding
OF401_05275	COG2003	Belongs to the UPF0758 family
OF401_05350	COG0745	RESPONSE REGULATOR receiver
OF401_05380	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
OF401_05390	COG4969	Belongs to the N-Me-Phe pilin family
OF401_05435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OF401_05435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OF401_05445	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OF401_05450	COG0564	pseudouridine synthase activity
OF401_05470	COG0840	transmembrane signaling receptor activity
OF401_05490	COG3387	PFAM Glycoside hydrolase 15-related
OF401_05495	COG1877	trehalose-phosphatase activity
OF401_05540	COG1116	anion transmembrane transporter activity
OF401_05545	COG0542	response to heat
OF401_05560	COG4206	TonB-dependent receptor
OF401_05580	COG1797	cobyrinic acid a,c-diamide synthase activity
OF401_05585	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
OF401_05625	COG0019	diaminopimelate decarboxylase activity
OF401_05630	COG4264	IucA IucC family
OF401_05635	COG2814	Major facilitator Superfamily
OF401_05640	COG4264	IucA IucC family
OF401_05650	COG4772	TonB-dependent receptor
OF401_05660	COG4651	solute:proton antiporter activity
OF401_05660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OF401_05690	COG0488	(ABC) transporter
OF401_05715	COG2755	lipolytic protein G-D-S-L family
OF401_05715	COG0657	acetylesterase activity
OF401_05735	COG0477	Major facilitator Superfamily
OF401_05800	COG2255	four-way junction helicase activity
OF401_05805	COG0824	Thioesterase
OF401_05815	COG0848	biopolymer transport protein
OF401_05830	COG2885	chlorophyll binding
OF401_05840	COG0602	queuosine metabolic process
OF401_05885	COG0583	DNA-binding transcription factor activity
OF401_05910	COG1187	pseudouridine synthase activity
OF401_05925	COG0514	ATP-dependent DNA helicase (RecQ)
OF401_05930	COG0783	Belongs to the Dps family
OF401_05935	COG1643	Atp-dependent helicase
OF401_05985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OF401_05995	COG1215	transferase activity, transferring glycosyl groups
OF401_06000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OF401_06010	COG1199	ATP-dependent helicase activity
OF401_06025	COG1397	ADP-ribosylglycohydrolase
OF401_06035	COG0189	ligase activity
OF401_06050	COG0835	chemotaxis
OF401_06055	COG0840	transmembrane signaling receptor activity
OF401_06060	COG2198	Histidine kinase
OF401_06060	COG0784	Response regulator, receiver
OF401_06060	COG0643	Histidine kinase
OF401_06085	COG1595	DNA-templated transcription, initiation
OF401_06095	COG2304	oxidoreductase activity
OF401_06100	COG1446	asparaginase
OF401_06145	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
OF401_06155	COG3645	SOS response
OF401_06200	COG3537	Alpha-1,2-mannosidase
OF401_06210	COG1472	Belongs to the glycosyl hydrolase 3 family
OF401_06220	COG3525	Glycosyl hydrolase, family 20, catalytic domain
OF401_06225	COG3858	chitin binding
OF401_06225	COG1388	LysM domain
OF401_06245	COG0837	glucose binding
OF401_06250	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OF401_06260	COG0494	nUDIX hydrolase
OF401_06265	COG1218	3'(2'),5'-bisphosphate nucleotidase
OF401_06270	COG3956	TIGRFAM MazG family protein
OF401_06280	COG0330	HflC and HflK could
OF401_06330	COG1960	acyl-CoA dehydrogenase activity
OF401_06340	COG1309	transcriptional regulator
OF401_06355	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
OF401_06365	COG0463	Glycosyl transferase, family 2
OF401_06370	COG0517	IMP dehydrogenase activity
OF401_06370	COG0516	GMP reductase activity
OF401_06375	COG2982	Protein involved in outer membrane biogenesis
OF401_06380	COG1272	protein, Hemolysin III
OF401_06395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OF401_06400	COG0626	cystathionine gamma-synthase activity
OF401_06405	COG0460	homoserine dehydrogenase
OF401_06405	COG0527	aspartate kinase activity
OF401_06420	COG1760	l-serine dehydratase
OF401_06440	COG2353	YceI-like domain
OF401_06460	COG0477	Major facilitator Superfamily
OF401_06500	COG1842	Phage shock protein A
OF401_06525	COG0754	glutathionylspermidine amidase activity
OF401_06530	COG2814	Major facilitator Superfamily
OF401_06595	COG0531	amino acid
OF401_06600	COG2197	response regulator
OF401_06620	COG1113	amino acid transport
OF401_06625	COG1271	oxidase subunit
OF401_06630	COG1294	oxidase, subunit
OF401_06640	COG2239	Acts as a magnesium transporter
OF401_06645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OF401_06650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OF401_06670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OF401_06685	COG1137	ATPase activity
OF401_06700	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
OF401_06710	COG0271	Belongs to the BolA IbaG family
OF401_06735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OF401_06755	COG0628	permease
OF401_06765	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
OF401_06780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OF401_06785	COG1555	photosystem II stabilization
OF401_06830	COG4774	siderophore transport
OF401_06835	COG2146	nitrite reductase [NAD(P)H] activity
OF401_06845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OF401_06850	COG0719	Fe-S assembly protein
OF401_06855	COG0396	ATPase activity
OF401_06860	COG0719	Fe-S assembly protein
OF401_06875	COG0693	protein deglycase activity
OF401_06910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
OF401_06940	COG0519	Catalyzes the synthesis of GMP from XMP
OF401_06945	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
OF401_06965	COG1764	response to oxidative stress
OF401_06975	COG0384	phenazine biosynthesis protein PhzF
OF401_06980	COG0384	phenazine biosynthesis protein PhzF
OF401_06985	COG0527	aspartate kinase activity
OF401_07010	COG0142	geranyltranstransferase activity
OF401_07015	COG0629	single-stranded DNA binding
OF401_07025	COG1401	restriction endodeoxyribonuclease activity
OF401_07040	COG2203	Gaf domain
OF401_07040	COG3706	GGDEF domain
OF401_07040	COG4251	negative regulation of phosphorylation
OF401_07040	COG5001	Diguanylate cyclase
OF401_07045	COG0604	alcohol dehydrogenase
OF401_07050	COG2080	2 iron, 2 sulfur cluster binding
OF401_07055	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
OF401_07060	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OF401_07065	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
OF401_07100	COG2879	small protein
OF401_07105	COG1966	Carbon starvation protein
OF401_07110	COG1741	Belongs to the pirin family
OF401_07130	COG1741	Belongs to the pirin family
OF401_07150	COG3590	peptidase
OF401_07155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OF401_07165	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OF401_07170	COG2202	Pas domain
OF401_07170	COG2200	EAL domain
OF401_07170	COG2199	diguanylate cyclase activity
OF401_07175	COG0835	chemotaxis
OF401_07180	COG0840	transmembrane signaling receptor activity
OF401_07185	COG2198	Histidine kinase
OF401_07185	COG0643	Histidine kinase
OF401_07195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OF401_07210	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
OF401_07215	COG0745	RESPONSE REGULATOR receiver
OF401_07225	COG2205	protein histidine kinase activity
OF401_07235	COG4452	Inner membrane protein CreD
OF401_07270	COG0735	belongs to the Fur family
OF401_07285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OF401_07295	COG1309	transcriptional regulator
OF401_07300	COG0667	Aldo Keto reductase
OF401_07315	COG2207	Transcriptional regulator
OF401_07335	COG0583	DNA-binding transcription factor activity
OF401_07340	COG2814	Major facilitator Superfamily
OF401_07360	COG1404	Belongs to the peptidase S8 family
OF401_07370	COG3383	formate dehydrogenase (NAD+) activity
OF401_07380	COG1271	oxidase subunit
OF401_07385	COG1294	oxidase, subunit
OF401_07485	COG5001	Diguanylate cyclase
OF401_07485	COG5002	protein histidine kinase activity
OF401_07490	COG1187	pseudouridine synthase activity
OF401_07515	COG0475	glutathione-regulated potassium exporter activity
OF401_07525	COG1132	(ABC) transporter
OF401_07580	COG2155	Conserved Protein
OF401_07590	COG3118	belongs to the thioredoxin family
OF401_07615	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OF401_07640	COG2968	Membrane
OF401_07655	COG3164	Protein of unknown function
OF401_07665	COG0312	modulator of DNA gyrase
OF401_07675	COG0312	modulator of DNA gyrase
OF401_07695	COG0142	geranyltranstransferase activity
OF401_07710	COG1785	Belongs to the alkaline phosphatase family
OF401_07715	COG1301	dicarboxylic acid transport
OF401_07720	COG4106	trans-aconitate 2-methyltransferase activity
OF401_07735	COG3852	Histidine kinase
OF401_07765	COG0791	NLP P60 protein
OF401_07770	COG0791	NLP P60 protein
OF401_07775	COG1047	Peptidyl-prolyl cis-trans
OF401_07780	COG2311	Membrane
OF401_07785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OF401_07790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OF401_07810	COG3590	peptidase
OF401_07815	COG3590	peptidase
OF401_07835	COG4206	TonB-dependent receptor
OF401_07840	COG0489	protein tyrosine kinase activity
OF401_07845	COG0717	Belongs to the dCTP deaminase family
OF401_07865	COG0412	Dienelactone hydrolase
OF401_07880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OF401_07895	COG0494	nUDIX hydrolase
OF401_07905	COG0433	COG0433 Predicted ATPase
OF401_07935	COG2890	protein-(glutamine-N5) methyltransferase activity
OF401_07950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OF401_07955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OF401_08040	COG4221	oxidoreductase activity
OF401_08060	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OF401_08080	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
OF401_08085	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
OF401_08105	COG0839	Belongs to the complex I subunit 6 family
OF401_08125	COG1007	ATP synthesis coupled electron transport
OF401_08140	COG0195	Participates in both transcription termination and antitermination
OF401_08200	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OF401_08210	COG2095	MarC family integral membrane protein
OF401_08220	COG1611	Belongs to the LOG family
OF401_08225	COG4969	Belongs to the N-Me-Phe pilin family
OF401_08280	COG3505	Type IV secretory pathway VirD4
OF401_08300	COG2948	multi-organism process
OF401_08320	COG3702	type iv secretory pathway
OF401_08340	COG0366	Alpha amylase catalytic
OF401_08350	COG3039	Transposase
OF401_08360	COG1082	Xylose isomerase domain protein TIM barrel
OF401_08390	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
OF401_08460	COG0438	transferase activity, transferring glycosyl groups
OF401_08470	COG2244	polysaccharide biosynthetic process
OF401_08475	COG0438	transferase activity, transferring glycosyl groups
OF401_08500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OF401_08510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OF401_08540	COG1960	acyl-CoA dehydrogenase activity
OF401_08565	COG0322	excinuclease ABC activity
OF401_08585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OF401_08595	COG4191	Histidine kinase
OF401_08595	COG0784	Response regulator, receiver
OF401_08615	COG0552	protein localization to endoplasmic reticulum
OF401_08625	COG3938	Belongs to the proline racemase family
OF401_08645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OF401_08655	COG0006	proline dipeptidase activity
OF401_08675	COG0531	amino acid
OF401_08705	COG1506	peptidase
OF401_08705	COG0823	Involved in the tonB-independent uptake of proteins
OF401_08715	COG4206	TonB-dependent receptor
OF401_08760	COG3039	Transposase
OF401_08770	COG0742	ribosomal rna small subunit methyltransferase
OF401_08790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OF401_08795	COG0405	Gamma-glutamyltransferase
OF401_08800	COG3291	Pkd domain containing protein
OF401_08830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OF401_08850	COG1862	Preprotein translocase
OF401_08860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OF401_08890	COG1105	Belongs to the carbohydrate kinase PfkB family
OF401_08895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OF401_08895	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OF401_08900	COG1609	Transcriptional regulator
OF401_08910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OF401_08915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OF401_08925	COG2902	Dehydrogenase
OF401_08930	COG1609	Transcriptional regulator
OF401_08930	COG2207	Transcriptional regulator
OF401_08935	COG1335	isochorismatase
OF401_08940	COG0477	Major facilitator Superfamily
OF401_08950	COG2205	protein histidine kinase activity
OF401_08950	COG5002	protein histidine kinase activity
OF401_08950	COG0784	Response regulator, receiver
OF401_08955	COG2733	membrane
OF401_08965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OF401_08970	COG2223	nitrite transmembrane transporter activity
OF401_08980	COG0243	molybdopterin cofactor binding
OF401_08990	COG0477	Major facilitator Superfamily
OF401_08995	COG2703	oxygen carrier activity
OF401_09005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OF401_09010	COG0174	glutamine synthetase
OF401_09015	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
OF401_09050	COG3842	ATPase activity
OF401_09060	COG1176	ABC-type spermidine putrescine transport system, permease component I
OF401_09065	COG1177	transmembrane transport
OF401_09075	COG1012	belongs to the aldehyde dehydrogenase family
OF401_09090	COG4535	Mg2 and Co2 transporter CorC
OF401_09110	COG1702	phosphate starvation-inducible protein PhoH
OF401_09130	COG0741	lytic transglycosylase activity
OF401_09135	COG0723	plastoquinol--plastocyanin reductase activity
OF401_09140	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
OF401_09145	COG2857	Cytochrome c1
OF401_09150	COG0625	glutathione transferase activity
OF401_09155	COG2969	positive regulation of protein catabolic process
OF401_09170	COG1201	RNA secondary structure unwinding
OF401_09180	COG0840	transmembrane signaling receptor activity
OF401_09185	COG0835	chemotaxis
OF401_09235	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OF401_09250	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
OF401_09255	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OF401_09255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OF401_09265	COG0860	N-Acetylmuramoyl-L-alanine amidase
OF401_09290	COG1028	Short-chain dehydrogenase reductase Sdr
OF401_09305	COG3300	MHYT domain
OF401_09305	COG5001	Diguanylate cyclase
OF401_09310	COG2081	HI0933 family
OF401_09315	COG4681	YaeQ
OF401_09350	COG0513	Belongs to the DEAD box helicase family
OF401_09355	COG0488	(ABC) transporter
OF401_09370	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OF401_09375	COG0483	inositol monophosphate 1-phosphatase activity
OF401_09390	COG3300	MHYT domain
OF401_09390	COG5001	Diguanylate cyclase
OF401_09395	COG1509	lysine 2,3-aminomutase activity
OF401_09410	COG0402	S-adenosylhomocysteine deaminase activity
OF401_09480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OF401_09510	COG2166	iron-sulfur cluster assembly
OF401_09525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
OF401_09535	COG0137	argininosuccinate synthase activity
OF401_09540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OF401_09545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OF401_09555	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
OF401_09575	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OF401_09610	COG1294	oxidase, subunit
OF401_09620	COG4988	ABC transporter
OF401_09625	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
OF401_09690	COG0436	Aminotransferase
OF401_09715	COG1187	pseudouridine synthase activity
OF401_09720	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
OF401_09725	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
OF401_09730	COG2350	Protein conserved in bacteria
OF401_09755	COG2182	Extracellular solute-binding protein
OF401_09765	COG0395	ABC-type sugar transport system, permease component
OF401_09790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OF401_09795	COG2957	Belongs to the agmatine deiminase family
OF401_09815	COG0539	negative regulation of cytoplasmic translation
OF401_09830	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
OF401_09845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OF401_09850	COG0475	glutathione-regulated potassium exporter activity
OF401_09850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OF401_09890	COG2197	response regulator
OF401_09905	COG1335	isochorismatase
OF401_09920	COG2814	Major facilitator Superfamily
OF401_09930	COG1914	H( )-stimulated, divalent metal cation uptake system
OF401_09950	COG0668	transmembrane transport
OF401_09975	COG1028	Short-chain dehydrogenase reductase Sdr
OF401_09980	COG1183	phosphatidylcholine synthase activity
OF401_09990	COG3243	poly(R)-hydroxyalkanoic acid synthase
OF401_10005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OF401_10005	COG0723	plastoquinol--plastocyanin reductase activity
OF401_10015	COG2183	response to ionizing radiation
OF401_10020	COG5001	Diguanylate cyclase
OF401_10035	COG0582	viral genome integration into host DNA
OF401_10125	COG0800	Aldolase
OF401_10130	COG0129	dihydroxy-acid dehydratase activity
OF401_10135	COG0363	glucosamine-6-phosphate deaminase activity
OF401_10145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OF401_10155	COG0354	folic acid binding
OF401_10170	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
OF401_10175	COG1053	succinate dehydrogenase
OF401_10185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OF401_10200	COG4591	ABC-type transport system involved in lipoprotein release permease component
OF401_10220	COG0811	peptide transport
OF401_10245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OF401_10260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OF401_10290	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
OF401_10325	COG1530	ribonuclease E activity
OF401_10335	COG0428	transporter
OF401_10525	COG3279	Response regulator of the LytR AlgR family
OF401_10535	COG3459	Glycosyltransferase 36 associated
OF401_10545	COG4191	Histidine kinase
OF401_10545	COG0784	Response regulator, receiver
OF401_10550	COG0840	transmembrane signaling receptor activity
OF401_10580	COG0840	transmembrane signaling receptor activity
OF401_10620	COG1733	regulation of RNA biosynthetic process
OF401_10635	COG1999	signal sequence binding
OF401_10650	COG3590	peptidase
OF401_10715	COG5001	Diguanylate cyclase
OF401_10725	COG2201	protein-glutamate methylesterase activity
OF401_10730	COG3685	Protein conserved in bacteria
OF401_10745	COG0579	oxidoreductase
OF401_10755	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
OF401_10765	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
OF401_10785	COG0243	molybdopterin cofactor binding
OF401_10795	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OF401_10800	COG2223	nitrite transmembrane transporter activity
OF401_10805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OF401_10815	COG1648	precorrin-2 dehydrogenase activity
OF401_10815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OF401_10825	COG0746	molybdenum cofactor guanylyltransferase activity
OF401_10830	COG0303	'Molybdopterin
OF401_10840	COG0708	Exodeoxyribonuclease III
OF401_10865	COG2124	cytochrome p450
OF401_10870	COG1028	Short-chain dehydrogenase reductase Sdr
OF401_10885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OF401_10900	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OF401_10935	COG1024	Enoyl-CoA hydratase
OF401_10935	COG1250	3-hydroxyacyl-CoA dehydrogenase
OF401_10940	COG0183	Belongs to the thiolase family
OF401_10945	COG0038	chloride channel
OF401_10950	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OF401_10970	COG1674	ftsk spoiiie
OF401_10975	COG0492	ferredoxin-NADP+ reductase activity
OF401_10995	COG0542	response to heat
OF401_11015	COG2915	High frequency lysogenization protein hflD homolog
OF401_11030	COG3039	Transposase
OF401_11050	COG4191	Histidine kinase
OF401_11070	COG0784	Response regulator, receiver
OF401_11070	COG0835	chemotaxis
OF401_11080	COG1558	bacterial-type flagellum-dependent cell motility
OF401_11085	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
OF401_11095	COG4787	bacterial-type flagellum-dependent cell motility
OF401_11120	COG3951	Flagellar rod assembly protein muramidase FlgJ
OF401_11120	COG1705	Flagellar rod assembly protein muramidase FlgJ
OF401_11130	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OF401_11135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OF401_11140	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
OF401_11170	COG2201	protein-glutamate methylesterase activity
OF401_11200	COG0438	transferase activity, transferring glycosyl groups
OF401_11200	COG1216	Glycosyl transferase, family 2
OF401_11205	COG1677	Flagellar hook-basal body complex protein FliE
OF401_11275	COG1684	flagellar biosynthetic protein fliR
OF401_11330	COG0643	Histidine kinase
OF401_11330	COG2198	Histidine kinase
OF401_11330	COG0784	Response regulator, receiver
OF401_11420	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
OF401_11425	COG1360	Flagellar Motor Protein
OF401_11435	COG0835	chemotaxis
OF401_11445	COG0745	RESPONSE REGULATOR receiver
OF401_11455	COG0840	transmembrane signaling receptor activity
OF401_11465	COG0840	transmembrane signaling receptor activity
OF401_11470	COG0840	transmembrane signaling receptor activity
OF401_11475	COG0840	transmembrane signaling receptor activity
OF401_11480	COG1196	nuclear chromosome segregation
OF401_11480	COG3264	Mechanosensitive ion channel
OF401_11485	COG0840	transmembrane signaling receptor activity
OF401_11490	COG0840	transmembrane signaling receptor activity
OF401_11495	COG0840	transmembrane signaling receptor activity
OF401_11505	COG0840	transmembrane signaling receptor activity
OF401_11515	COG0835	chemotaxis
OF401_11525	COG0840	transmembrane signaling receptor activity
OF401_11550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OF401_11580	COG0318	PFAM AMP-dependent synthetase and ligase
OF401_11585	COG1024	Enoyl-CoA hydratase
OF401_11590	COG0784	Response regulator, receiver
OF401_11590	COG2205	protein histidine kinase activity
OF401_11590	COG2198	Histidine kinase
OF401_11595	COG0784	Response regulator, receiver
OF401_11595	COG2205	protein histidine kinase activity
OF401_11595	COG2198	Histidine kinase
OF401_11615	COG3279	Response regulator of the LytR AlgR family
OF401_11635	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OF401_11645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OF401_11650	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
OF401_11660	COG0505	Belongs to the CarA family
OF401_11670	COG2258	MOSC domain
OF401_11675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OF401_11700	COG1024	Enoyl-CoA hydratase
OF401_11735	COG0277	FAD linked oxidase domain protein
OF401_11740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OF401_11755	COG0531	amino acid
OF401_11760	COG0531	amino acid
OF401_11790	COG0140	phosphoribosyl-ATP diphosphatase activity
OF401_11790	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OF401_11810	COG0131	Imidazoleglycerol-phosphate dehydratase
OF401_11810	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
OF401_11820	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OF401_11835	COG0124	histidyl-tRNA synthetase
OF401_11840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OF401_11850	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
OF401_11860	COG0083	homoserine kinase activity
OF401_11915	COG1012	belongs to the aldehyde dehydrogenase family
OF401_11940	COG0697	spore germination
OF401_11945	COG1794	racemase activity, acting on amino acids and derivatives
OF401_11955	COG0671	phosphoesterase, PA-phosphatase related
OF401_11970	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
OF401_11975	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
OF401_11980	COG5001	Diguanylate cyclase
OF401_11980	COG4251	negative regulation of phosphorylation
OF401_11980	COG2203	Gaf domain
OF401_11980	COG3706	GGDEF domain
OF401_11990	COG1472	Belongs to the glycosyl hydrolase 3 family
OF401_12045	COG0860	N-Acetylmuramoyl-L-alanine amidase
OF401_12065	COG0477	Major facilitator Superfamily
OF401_12075	COG1070	Carbohydrate kinase
OF401_12085	COG1501	Belongs to the glycosyl hydrolase 31 family
OF401_12125	COG0800	Aldolase
OF401_12140	COG3734	2-keto-3-deoxy-galactonokinase
OF401_12145	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
OF401_12155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OF401_12170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
OF401_12175	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
OF401_12185	COG0351	phosphomethylpyrimidine kinase
OF401_12185	COG0352	thiamine-phosphate diphosphorylase activity
OF401_12210	COG0583	DNA-binding transcription factor activity
OF401_12215	COG1741	Belongs to the pirin family
OF401_12220	COG1741	Belongs to the pirin family
OF401_12240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OF401_12255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OF401_12265	COG4771	TonB-dependent receptor
OF401_12275	COG1546	Belongs to the CinA family
OF401_12280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OF401_12295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OF401_12300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OF401_12310	COG1534	Rna-binding protein
OF401_12325	COG1238	metal cluster binding
OF401_12340	COG2840	Smr protein MutS2
OF401_12400	COG2134	cdp-diacylglycerol pyrophosphatase
OF401_12425	COG1253	flavin adenine dinucleotide binding
OF401_12440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OF401_12445	COG0477	Major facilitator Superfamily
OF401_12450	COG1132	(ABC) transporter
OF401_12470	COG0438	transferase activity, transferring glycosyl groups
OF401_12475	COG0438	transferase activity, transferring glycosyl groups
OF401_12480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OF401_12510	COG2244	polysaccharide biosynthetic process
OF401_12525	COG3038	cytochrome b561
OF401_12545	COG1595	DNA-templated transcription, initiation
OF401_12560	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OF401_12580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OF401_12595	COG0784	Response regulator, receiver
OF401_12595	COG4191	Histidine kinase
OF401_12600	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
OF401_12655	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
OF401_12705	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
OF401_12740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OF401_12875	COG2003	Belongs to the UPF0758 family
OF401_12905	COG0497	DNA recombination
OF401_12940	COG0583	DNA-binding transcription factor activity
OF401_12955	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
OF401_12965	COG1605	Chorismate mutase
OF401_12965	COG0077	Prephenate dehydratase
OF401_12975	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
OF401_13030	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
OF401_13040	COG4993	Dehydrogenase
OF401_13060	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
OF401_13070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OF401_13110	COG0316	Belongs to the HesB IscA family
OF401_13140	COG0288	reversible hydration of carbon dioxide
OF401_13165	COG2925	Exonuclease
OF401_13180	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
OF401_13200	COG0488	(ABC) transporter
OF401_13240	COG0494	nUDIX hydrolase
OF401_13250	COG1024	Enoyl-CoA hydratase
OF401_13260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OF401_13265	COG0659	secondary active sulfate transmembrane transporter activity
OF401_13290	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OF401_13295	COG0573	inorganic phosphate transmembrane transporter activity
OF401_13300	COG0581	inorganic phosphate transmembrane transporter activity
OF401_13310	COG0704	Plays a role in the regulation of phosphate uptake
OF401_13330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OF401_13340	COG0557	exoribonuclease II activity
OF401_13355	COG1960	acyl-CoA dehydrogenase activity
OF401_13360	COG1960	acyl-CoA dehydrogenase activity
OF401_13365	COG2226	methyltransferase
OF401_13370	COG0646	methionine synthase
OF401_13370	COG1410	methionine synthase
OF401_13375	COG0646	methionine synthase
OF401_13375	COG1410	methionine synthase
OF401_13385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OF401_13395	COG1609	Transcriptional regulator
OF401_13435	COG0386	Belongs to the glutathione peroxidase family
OF401_13445	COG1725	Transcriptional regulator
OF401_13450	COG1131	(ABC) transporter
OF401_13495	COG2850	peptidyl-arginine hydroxylation
OF401_13530	COG1132	(ABC) transporter
OF401_13535	COG0583	DNA-binding transcription factor activity
OF401_13540	COG2274	protein secretion by the type I secretion system
OF401_13565	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
OF401_13585	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OF401_13590	COG1420	regulation of RNA biosynthetic process
OF401_13595	COG0497	DNA recombination
OF401_13605	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OF401_13625	COG1404	Belongs to the peptidase S8 family
OF401_13670	COG3081	Nucleoid-associated protein
OF401_13745	COG1401	restriction endodeoxyribonuclease activity
OF401_13765	COG2944	sequence-specific DNA binding
OF401_13800	COG2003	Belongs to the UPF0758 family
OF401_13815	COG3279	Response regulator of the LytR AlgR family
OF401_13820	COG3275	phosphorelay sensor kinase activity
OF401_13825	COG3039	Transposase
OF401_13835	COG2814	Major facilitator Superfamily
OF401_13855	COG0840	transmembrane signaling receptor activity
OF401_13860	COG1858	cytochrome C peroxidase
OF401_13870	COG3712	iron ion homeostasis
OF401_13875	COG1595	DNA-templated transcription, initiation
OF401_13880	COG3039	Transposase
OF401_13930	COG3706	GGDEF domain
OF401_13950	COG1028	Short-chain dehydrogenase reductase Sdr
OF401_13960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OF401_13970	COG0583	DNA-binding transcription factor activity
OF401_13980	COG0415	Belongs to the DNA photolyase family
OF401_13985	COG0305	Participates in initiation and elongation during chromosome replication
OF401_13995	COG0367	asparagine synthase
OF401_14010	COG1960	acyl-CoA dehydrogenase activity
OF401_14025	COG0084	hydrolase, TatD family'
OF401_14030	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OF401_14090	COG0386	Belongs to the glutathione peroxidase family
OF401_14095	COG0339	signal peptide processing
OF401_14130	COG3104	oligopeptide transport
OF401_14160	COG2814	Major facilitator Superfamily
OF401_14165	COG1566	PFAM secretion protein HlyD family protein
OF401_14205	COG4774	siderophore transport
OF401_14215	COG0367	asparagine synthase
OF401_14230	COG1393	Belongs to the ArsC family
OF401_14300	COG0528	UMP kinase activity
OF401_14310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OF401_14315	COG0575	Belongs to the CDS family
OF401_14325	COG0750	zinc metalloprotease
OF401_14380	COG1981	membrane
OF401_14405	COG1695	Transcriptional regulator
OF401_14430	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
OF401_14440	COG2040	homocysteine
OF401_14445	COG0833	amino acid
OF401_14450	COG0346	lactoylglutathione lyase activity
OF401_14475	COG2878	Part of a membrane complex involved in electron transport
OF401_14490	COG1595	DNA-templated transcription, initiation
OF401_14515	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OF401_14530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OF401_14535	COG0251	oxidation-reduction process
OF401_14545	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
OF401_14545	COG0392	lysyltransferase activity
OF401_14580	COG2814	Major facilitator Superfamily
OF401_14585	COG1902	pentaerythritol trinitrate reductase activity
OF401_14605	COG2824	Alkylphosphonate utilization operon protein PhnA
OF401_14615	COG1047	Peptidyl-prolyl cis-trans
OF401_14665	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OF401_14675	COG5487	UPF0391 membrane protein
OF401_14680	COG1451	nucleotide metabolic process
OF401_14700	COG0183	Belongs to the thiolase family
OF401_14735	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
OF401_14735	COG1793	dna ligase
OF401_14745	COG1793	dna ligase
OF401_14750	COG1201	RNA secondary structure unwinding
OF401_14760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OF401_14765	COG1278	Cold shock
OF401_14770	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
OF401_14775	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
OF401_14785	COG3046	protein related to deoxyribodipyrimidine photolyase
OF401_14790	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
OF401_14790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OF401_14795	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OF401_14800	COG2954	triphosphatase activity
OF401_14845	COG0481	GTPase activity
OF401_14850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OF401_14880	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
OF401_14885	COG1024	Enoyl-CoA hydratase
OF401_14890	COG1960	acyl-CoA dehydrogenase activity
OF401_14900	COG1396	sequence-specific DNA binding
OF401_14900	COG3800	Transcriptional regulator
OF401_14910	COG3867	Arabinogalactan endo-beta-1,4-galactanase
OF401_14915	COG3250	beta-galactosidase activity
OF401_14920	COG3039	Transposase
OF401_14960	COG3039	Transposase
OF401_15050	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OF401_15105	COG5297	Belongs to the glycosyl hydrolase family 6
OF401_15125	COG1309	transcriptional regulator
OF401_15130	COG0436	Aminotransferase
OF401_15140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OF401_15155	COG3483	tryptophan 2,3-dioxygenase activity
OF401_15165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
OF401_15185	COG0534	Mate efflux family protein
OF401_15215	COG2070	2-Nitropropane dioxygenase
OF401_15230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OF401_15235	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OF401_15245	COG3534	alpha-L-arabinofuranosidase
OF401_15275	COG0784	Response regulator, receiver
OF401_15275	COG4191	Histidine kinase
OF401_15280	COG3850	Histidine kinase
OF401_15280	COG3437	response regulator, receiver
OF401_15280	COG2205	protein histidine kinase activity
OF401_15280	COG4999	Histidine kinase
OF401_15285	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OF401_15295	COG2205	protein histidine kinase activity
OF401_15300	COG5507	3-demethylubiquinone-9 3-methyltransferase
OF401_15310	COG4771	TonB-dependent receptor
OF401_15340	COG2172	sigma factor antagonist activity
OF401_15345	COG1366	Belongs to the anti-sigma-factor antagonist family
OF401_15350	COG1366	Belongs to the anti-sigma-factor antagonist family
OF401_15355	COG1902	pentaerythritol trinitrate reductase activity
OF401_15365	COG0326	Molecular chaperone. Has ATPase activity
OF401_15370	COG2207	Transcriptional regulator
OF401_15385	COG3152	Membrane
OF401_15400	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OF401_15405	COG1845	cytochrome c oxidase, subunit III
OF401_15410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OF401_15440	COG0196	riboflavin kinase activity
OF401_15445	COG0728	peptidoglycan biosynthetic process
OF401_15470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OF401_15475	COG0824	Thioesterase
OF401_15480	COG1024	Enoyl-CoA hydratase
OF401_15485	COG1946	Acyl-CoA thioesterase
OF401_15500	COG1595	DNA-templated transcription, initiation
OF401_15560	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
OF401_15590	COG2197	response regulator
OF401_15595	COG4585	Histidine kinase
OF401_15605	COG0850	regulation of cytokinetic process
OF401_15610	COG2894	cell division
OF401_15625	COG5002	protein histidine kinase activity
OF401_15630	COG0745	RESPONSE REGULATOR receiver
OF401_15665	COG2814	Major facilitator Superfamily
OF401_15685	COG0656	L-ascorbic acid biosynthetic process
OF401_15690	COG0753	catalase activity
OF401_15705	COG1917	Cupin 2, conserved barrel domain protein
OF401_15705	COG2207	Transcriptional regulator
OF401_15725	COG1506	peptidase
OF401_15725	COG0823	Involved in the tonB-independent uptake of proteins
OF401_15735	COG1297	OPT oligopeptide transporter protein
OF401_15760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OF401_15790	COG2080	2 iron, 2 sulfur cluster binding
OF401_15795	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
OF401_15800	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OF401_15845	COG1028	Short-chain dehydrogenase reductase Sdr
OF401_15850	COG3537	Alpha-1,2-mannosidase
OF401_15860	COG1028	Short-chain dehydrogenase reductase Sdr
OF401_15865	COG3387	PFAM Glycoside hydrolase 15-related
OF401_15875	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OF401_15920	COG3039	Transposase
OF401_15970	COG1309	transcriptional regulator
OF401_15975	COG1028	Short-chain dehydrogenase reductase Sdr
OF401_16005	COG0308	aminopeptidase N
OF401_16020	COG0330	HflC and HflK could
OF401_16025	COG0330	HflC and HflK could
OF401_16045	COG0678	peroxiredoxin activity
OF401_16055	COG4953	penicillin-binding protein 1C
OF401_16080	COG2373	Large extracellular alpha-helical protein
OF401_16110	COG3609	addiction module antidote protein, CC2985 family
OF401_16130	COG3829	transcription factor binding
OF401_16175	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OF401_16180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
OF401_16195	COG1028	Short-chain dehydrogenase reductase Sdr
OF401_16200	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OF401_16215	COG1399	metal-binding, possibly nucleic acid-binding protein
OF401_16250	COG0714	Associated with various cellular activities
OF401_16270	COG0537	adenosine 5'-monophosphoramidase activity
OF401_16300	COG0314	molybdopterin synthase activity
OF401_16305	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
OF401_16325	COG1234	tRNA 3'-trailer cleavage
OF401_16335	COG0859	PFAM glycosyl transferase family 9
OF401_16400	COG0631	protein serine/threonine phosphatase activity
OF401_16405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OF401_16430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OF401_16505	COG0473	3-isopropylmalate dehydrogenase activity
OF401_16520	COG4783	chaperone-mediated protein folding
OF401_16525	COG0745	RESPONSE REGULATOR receiver
OF401_16535	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
OF401_16545	COG0438	transferase activity, transferring glycosyl groups
OF401_16550	COG0671	phosphoesterase, PA-phosphatase related
OF401_16555	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OF401_16565	COG3291	Pkd domain containing protein
OF401_16570	COG2833	Protein of unknown function (DUF455)
OF401_16590	COG0285	dihydrofolate synthase activity
OF401_16605	COG0406	alpha-ribazole phosphatase activity
OF401_16630	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
OF401_16635	COG4208	sulfate ABC transporter
OF401_16640	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
OF401_16645	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
OF401_16680	COG1902	pentaerythritol trinitrate reductase activity
OF401_16680	COG0446	pyridine nucleotide-disulphide oxidoreductase
OF401_16685	COG3039	Transposase
OF401_16705	COG0625	glutathione transferase activity
OF401_16715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OF401_16720	COG1217	gtp-binding protein TYPA
OF401_16730	COG0154	amidase activity
OF401_16745	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
OF401_16780	COG0201	protein transport
OF401_16940	COG0250	Participates in transcription elongation, termination and antitermination
OF401_16975	COG0012	GTP binding
OF401_16980	COG0193	aminoacyl-tRNA hydrolase activity
OF401_16990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OF401_17030	COG0521	Mo-molybdopterin cofactor biosynthetic process
OF401_17050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OF401_17080	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OF401_17085	COG1404	Belongs to the peptidase S8 family
OF401_17095	COG1404	Belongs to the peptidase S8 family
OF401_17100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OF401_17165	COG0778	Nitroreductase
OF401_17170	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OF401_17170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OF401_17190	COG2890	protein-(glutamine-N5) methyltransferase activity
OF401_17200	COG3634	alkyl hydroperoxide reductase activity
OF401_17205	COG0583	DNA-binding transcription factor activity
OF401_17210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OF401_17235	COG2197	response regulator
OF401_17240	COG0784	Response regulator, receiver
OF401_17240	COG5002	protein histidine kinase activity
OF401_17240	COG2205	protein histidine kinase activity
OF401_17270	COG0697	spore germination
OF401_17300	COG3386	PFAM SMP-30 Gluconolaconase
OF401_17320	COG1024	Enoyl-CoA hydratase
OF401_17330	COG0318	PFAM AMP-dependent synthetase and ligase
OF401_17335	COG0583	DNA-binding transcription factor activity
OF401_17340	COG3384	dioxygenase
OF401_17370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OF401_17375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OF401_17385	COG2096	Adenosyltransferase
OF401_17390	COG0123	including yeast histone deacetylase and acetoin utilization protein
OF401_17420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OF401_17455	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
OF401_17465	COG0642	Histidine kinase
OF401_17480	COG4181	ATPase activity
OF401_17490	COG2175	clavaminate synthase activity
OF401_17500	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
OF401_17525	COG4771	TonB-dependent receptor
OF401_17535	COG0667	Aldo Keto reductase
OF401_17540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OF401_17550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OF401_17605	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
OF401_17645	COG0366	Alpha amylase catalytic
OF401_17680	COG0604	alcohol dehydrogenase
OF401_17680	COG1028	Short-chain dehydrogenase reductase Sdr
OF401_17680	COG3321	synthase
OF401_17695	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OF401_17710	COG0494	nUDIX hydrolase
OF401_17725	COG0739	heme binding
OF401_17755	COG1181	Belongs to the D-alanine--D-alanine ligase family
OF401_17780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OF401_17795	COG3116	cell division
OF401_17845	COG1988	membrane-bound metal-dependent
OF401_17850	COG0277	FAD linked oxidase domain protein
OF401_17860	COG0745	RESPONSE REGULATOR receiver
OF401_17865	COG2205	protein histidine kinase activity
OF401_17875	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
OF401_17880	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
OF401_17895	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OF401_17925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OF401_17925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OF401_17950	COG0488	(ABC) transporter
OF401_17955	COG0242	peptide deformylase activity
OF401_17960	COG1393	Belongs to the ArsC family
OF401_17975	COG0457	Tetratricopeptide repeat
OF401_17980	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
OF401_17985	COG1215	transferase activity, transferring glycosyl groups
OF401_17990	COG1215	transferase activity, transferring glycosyl groups
OF401_18055	COG2188	Transcriptional regulator
OF401_18065	COG1450	Type ii and iii secretion system protein
OF401_18080	COG3166	PFAM Fimbrial assembly family protein
OF401_18085	COG3156	type II secretion system protein K
OF401_18090	COG4795	General secretion pathway protein
OF401_18095	COG2165	general secretion pathway protein
OF401_18100	COG4970	Tfp pilus assembly protein FimT
OF401_18105	COG2165	general secretion pathway protein
OF401_18110	COG1459	type II secretion system
OF401_18115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OF401_18120	COG1404	Belongs to the peptidase S8 family
OF401_18135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OF401_18135	COG0047	phosphoribosylformylglycinamidine synthase activity
OF401_18140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OF401_18145	COG4974	Belongs to the 'phage' integrase family
OF401_18160	COG0795	lipopolysaccharide-transporting ATPase activity
OF401_18225	COG1183	phosphatidylcholine synthase activity
OF401_18250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OF401_18255	COG1127	ABC transporter
OF401_18260	COG3218	ABC-type transport auxiliary lipoprotein component
OF401_18260	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OF401_18300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OF401_18305	COG0662	Cupin 2, conserved barrel domain protein
OF401_18305	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
OF401_18330	COG2086	electron transfer activity
OF401_18340	COG0662	Cupin 2, conserved barrel domain protein
OF401_18340	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
OF401_18345	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
OF401_18350	COG0463	Glycosyl transferase, family 2
OF401_18390	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
OF401_18405	COG0438	transferase activity, transferring glycosyl groups
OF401_18430	COG0626	cystathionine gamma-synthase activity
OF401_18460	COG0625	glutathione transferase activity
OF401_18470	COG0513	Belongs to the DEAD box helicase family
OF401_18475	COG0720	synthase
OF401_18490	COG1956	GAF domain-containing protein
OF401_18520	COG0339	signal peptide processing
OF401_18525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OF401_18575	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OF401_18585	COG1136	(ABC) transporter
OF401_18595	COG0577	efflux transmembrane transporter activity
OF401_18595	COG1136	(ABC) transporter
OF401_18610	COG4191	Histidine kinase
OF401_18675	COG0356	it plays a direct role in the translocation of protons across the membrane
OF401_18690	COG1228	amidohydrolase
OF401_18695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OF401_18705	COG0508	dehydrogenase complex catalyzes the overall conversion of
OF401_18745	COG2011	ABC-type metal ion transport system permease component
OF401_18755	COG0697	spore germination
OF401_18785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OF401_18790	COG1187	pseudouridine synthase activity
OF401_18795	COG2813	Specifically methylates the guanine in position
OF401_18815	COG5002	protein histidine kinase activity
OF401_18895	COG0842	Transport permease protein
OF401_18900	COG1131	(ABC) transporter
OF401_18905	COG0025	NhaP-type Na H and K H
OF401_18910	COG3795	YCII-related domain
OF401_18915	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
OF401_18920	COG1573	uracil-dna glycosylase
OF401_18930	COG3384	dioxygenase
OF401_18935	COG0583	DNA-binding transcription factor activity
OF401_18945	COG0667	Aldo Keto reductase
OF401_18955	COG3590	peptidase
OF401_18970	COG0531	amino acid
OF401_18985	COG2972	Histidine kinase
OF401_19005	COG1335	isochorismatase
OF401_19010	COG3685	Protein conserved in bacteria
OF401_19015	COG3685	Protein conserved in bacteria
OF401_19020	COG3546	catalase activity
OF401_19050	COG2204	response regulator
OF401_19060	COG1271	oxidase subunit
OF401_19065	COG1294	oxidase, subunit
OF401_19080	COG1028	Short-chain dehydrogenase reductase Sdr
OF401_19085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OF401_19105	COG1132	(ABC) transporter
OF401_19120	COG1063	alcohol dehydrogenase
OF401_19160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OF401_19220	COG0251	oxidation-reduction process
OF401_19240	COG0667	Aldo Keto reductase
OF401_19245	COG0583	DNA-binding transcription factor activity
OF401_19270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OF401_19280	COG1560	Kdo2-lipid A biosynthetic process
OF401_19290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OF401_19325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OF401_19325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OF401_19335	COG0242	peptide deformylase activity
OF401_19340	COG1652	LysM domain
OF401_19345	COG0758	DNA mediated transformation
OF401_19365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OF401_19365	COG1754	DNA topoisomerase type I activity
OF401_19385	COG5001	Diguanylate cyclase
OF401_19385	COG4251	negative regulation of phosphorylation
OF401_19385	COG2203	Gaf domain
OF401_19385	COG3706	GGDEF domain
OF401_19390	COG1028	Short-chain dehydrogenase reductase Sdr
OF401_19400	COG0616	signal peptide processing
OF401_19405	COG0534	Mate efflux family protein
OF401_19420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OF401_19425	COG0625	glutathione transferase activity
OF401_19440	COG1252	NADH dehydrogenase
OF401_19445	COG2860	membrane
OF401_19450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OF401_19460	COG2201	protein-glutamate methylesterase activity
OF401_19465	COG2177	Part of the ABC transporter FtsEX involved in
OF401_19470	COG2884	Cell division ATP-binding protein ftsE
OF401_19480	COG3118	belongs to the thioredoxin family
OF401_19485	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
OF401_19530	COG1473	amidohydrolase
OF401_19535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OF401_19540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OF401_19560	COG4941	Belongs to the sigma-70 factor family
OF401_19565	COG5383	Protein conserved in bacteria
OF401_19605	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
OF401_19610	COG3501	Rhs element vgr protein
OF401_19610	COG3409	Peptidoglycan-binding domain 1 protein
OF401_19625	COG3023	N-Acetylmuramoyl-L-alanine amidase
OF401_19635	COG4948	Mandelate Racemase Muconate Lactonizing
OF401_19645	COG0531	amino acid
OF401_19660	COG4682	membrane
OF401_19665	COG2133	pyrroloquinoline quinone binding
OF401_19675	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OF401_19690	COG1610	YqeY-like protein
OF401_19695	COG1295	ribonuclease BN
OF401_19700	COG0358	DNA primase activity
OF401_19750	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
OF401_19765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OF401_19820	COG0739	heme binding
OF401_19835	COG2223	nitrite transmembrane transporter activity
OF401_19840	COG0708	Exodeoxyribonuclease III
OF401_19855	COG1192	Involved in chromosome partitioning
OF401_19860	COG1475	DNA binding
OF401_19880	COG0463	Glycosyl transferase, family 2
OF401_19905	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OF401_19930	COG4221	oxidoreductase activity
OF401_19935	COG2755	lipolytic protein G-D-S-L family
OF401_19935	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
OF401_19955	COG1166	arginine decarboxylase activity
OF401_19980	COG2960	long-chain fatty acid transporting porin activity
OF401_19985	COG0606	chelatase, subunit chli
OF401_20000	COG4943	cyclic-guanylate-specific phosphodiesterase activity
OF401_20040	COG1690	Belongs to the RtcB family
OF401_20085	COG1090	epimerase
OF401_20105	COG0642	Histidine kinase
OF401_20125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OF401_20150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OF401_20155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OF401_20175	COG2197	response regulator
OF401_20180	COG4585	Histidine kinase
OF401_20195	COG1136	(ABC) transporter
OF401_20220	COG0697	spore germination
OF401_20255	COG0180	Tryptophanyl-tRNA synthetase
OF401_20260	COG3237	CsbD-like
OF401_20335	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
OF401_20335	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
OF401_20375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OF401_20400	COG1199	ATP-dependent helicase activity
OF401_20460	COG0625	glutathione transferase activity
OF401_20500	COG4555	ABC transporter
OF401_20510	COG1476	TRANSCRIPTIONal
OF401_20525	COG1230	cation diffusion facilitator family transporter
OF401_20535	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OF401_20540	COG1131	(ABC) transporter
OF401_20545	COG0842	Transport permease protein
OF401_20555	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OF401_20570	COG1607	acyl-coa hydrolase
OF401_20580	COG0716	FMN binding
OF401_20585	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OF401_20590	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OF401_20600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OF401_20600	COG0045	succinate-CoA ligase (ADP-forming) activity
OF401_20600	COG1042	CoA-binding domain protein
OF401_20610	COG2239	Acts as a magnesium transporter
OF401_20625	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OF401_20630	COG3387	PFAM Glycoside hydrolase 15-related
OF401_20650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OF401_20660	COG0463	Glycosyl transferase, family 2
OF401_20680	COG1028	Short-chain dehydrogenase reductase Sdr
OF401_20725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OF401_20795	COG0210	DNA helicase
OF401_20805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OF401_20815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OF401_20825	COG2159	amidohydrolase
OF401_20885	COG2091	lysine biosynthetic process via aminoadipic acid
OF401_20940	COG1940	carbohydrate kinase activity
OF401_20950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OF401_20960	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OF401_20965	COG3162	membrane
OF401_21000	COG3507	Belongs to the glycosyl hydrolase 43 family
OF401_21015	COG1028	Short-chain dehydrogenase reductase Sdr
OF401_21020	COG0179	Fumarylacetoacetate (FAA) hydrolase
OF401_21025	COG4948	Mandelate Racemase Muconate Lactonizing
OF401_21035	COG3254	rhamnose metabolic process
OF401_21040	COG0738	Major facilitator superfamily
OF401_21045	COG1414	Transcriptional regulator
OF401_21065	COG2205	protein histidine kinase activity
OF401_21065	COG0784	Response regulator, receiver
OF401_21070	COG3039	Transposase
OF401_21075	COG3459	Glycosyltransferase 36 associated
OF401_21080	COG2211	Major facilitator Superfamily
OF401_21085	COG3265	gluconokinase activity
OF401_21090	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OF401_21110	COG2911	Protein conserved in bacteria
OF401_21115	COG0729	surface antigen
OF401_21130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OF401_21135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OF401_21135	COG0519	Catalyzes the synthesis of GMP from XMP
OF401_21145	COG0805	protein transport
OF401_21165	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OF401_21205	COG3661	Belongs to the glycosyl hydrolase 67 family
OF401_21215	COG4948	Mandelate Racemase Muconate Lactonizing
OF401_21225	COG1472	Belongs to the glycosyl hydrolase 3 family
OF401_21230	COG0246	Mannitol dehydrogenase
OF401_21270	COG3386	PFAM SMP-30 Gluconolaconase
OF401_21285	COG3250	beta-galactosidase activity
OF401_21295	COG3693	PFAM glycoside hydrolase, family 10
OF401_21310	COG2211	Major facilitator Superfamily
OF401_21350	COG2937	Belongs to the GPAT DAPAT family
OF401_21385	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
OF401_21405	COG0210	DNA helicase
OF401_21415	COG3002	Belongs to the UPF0753 family
OF401_21475	COG3135	benzoate transporter
OF401_21500	COG0676	glucose-6-phosphate 1-epimerase activity
OF401_21520	COG0730	response to heat
OF401_21545	COG0302	gtp cyclohydrolase
OF401_21560	COG1566	PFAM secretion protein HlyD family protein
OF401_21570	COG1289	transmembrane transporter activity
OF401_21575	COG0477	Major facilitator Superfamily
OF401_21585	COG0583	DNA-binding transcription factor activity
OF401_21590	COG4221	oxidoreductase activity
OF401_21595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OF401_21665	COG0564	pseudouridine synthase activity
OF401_21715	COG1074	ATP-dependent DNA helicase activity
OF401_21720	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
OF401_21765	COG1127	ABC transporter
OF401_21770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OF401_21775	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OF401_21790	COG2853	Lipoprotein
OF401_21800	COG0386	Belongs to the glutathione peroxidase family
OF401_21810	COG1322	Protein conserved in bacteria
OF401_21820	COG0604	alcohol dehydrogenase
OF401_21825	COG0583	DNA-binding transcription factor activity
OF401_21840	COG0531	amino acid
OF401_21850	COG4206	TonB-dependent receptor
OF401_21860	COG3706	GGDEF domain
OF401_21865	COG3835	regulator
OF401_21870	COG1929	Belongs to the glycerate kinase type-1 family
OF401_21875	COG2271	Major facilitator Superfamily
OF401_21895	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OF401_21900	COG0861	Integral membrane protein TerC family
OF401_21915	COG0584	glycerophosphoryl diester phosphodiesterase
OF401_21935	COG0671	phosphoesterase, PA-phosphatase related
OF401_21950	COG0726	polysaccharide deacetylase
OF401_21955	COG0706	membrane insertase activity
OF401_22020	COG4962	Type ii secretion system protein e
OF401_22035	COG3451	type IV secretory pathway VirB4
OF401_22050	COG3846	protein secretion by the type IV secretion system
OF401_22085	COG0551	DNA topoisomerase type I activity
OF401_22085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OF401_22135	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs