locus-tag	class	description
XC_0004	COG0187	DNA topoisomerase II activity
XC_0006	COG0501	Belongs to the peptidase M48B family
XC_0014	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XC_0020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XC_0021	COG0793	Belongs to the peptidase S41A family
XC_0022	COG4942	peptidase
XC_0024	COG2234	aminopeptidase activity
XC_0026	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XC_0027	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XC_0028	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XC_0029	COG1064	alcohol dehydrogenase
XC_0031	COG0493	'glutamate synthase
XC_0032	COG0067	glutamate synthase
XC_0032	COG0069	glutamate synthase activity
XC_0032	COG0070	glutamate synthase
XC_0035	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XC_0037	COG1741	Belongs to the pirin family
XC_0043	COG0583	DNA-binding transcription factor activity
XC_0054	COG1111	helicase
XC_0054	COG1205	dead DEAH box helicase
XC_0055	COG3177	Filamentation induced by cAMP protein fic
XC_0056	COG1272	protein, Hemolysin III
XC_0060	COG2249	NAD(P)H dehydrogenase (quinone) activity
XC_0062	COG1733	regulation of RNA biosynthetic process
XC_0070	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
XC_0071	COG3237	CsbD-like
XC_0080	COG0628	permease
XC_0083	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XC_0084	COG0477	Major facilitator Superfamily
XC_0092	COG0714	Associated with various cellular activities
XC_0101	COG4772	TonB-dependent receptor
XC_0104	COG1012	belongs to the aldehyde dehydrogenase family
XC_0112	COG1755	Isoprenylcysteine carboxyl methyltransferase
XC_0113	COG4585	Histidine kinase
XC_0114	COG2197	response regulator
XC_0118	COG3710	Transcriptional regulator
XC_0122	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XC_0133	COG3039	Transposase
XC_0141	COG0366	Alpha amylase catalytic
XC_0142	COG0366	Alpha amylase catalytic
XC_0151	COG2755	lipolytic protein G-D-S-L family
XC_0153	COG0657	acetylesterase activity
XC_0153	COG2755	lipolytic protein G-D-S-L family
XC_0155	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XC_0158	COG3507	Belongs to the glycosyl hydrolase 43 family
XC_0159	COG1609	Transcriptional regulator
XC_0161	COG1028	Short-chain dehydrogenase reductase Sdr
XC_0163	COG2755	lipolytic protein G-D-S-L family
XC_0165	COG3186	Phenylalanine-4-hydroxylase
XC_0166	COG1522	sequence-specific DNA binding
XC_0168	COG1752	Esterase of the alpha-beta hydrolase superfamily
XC_0170	COG1119	ATPase activity
XC_0173	COG1125	glycine betaine transport
XC_0173	COG0517	IMP dehydrogenase activity
XC_0176	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XC_0177	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
XC_0183	COG0489	protein tyrosine kinase activity
XC_0184	COG0588	phosphoglycerate mutase activity
XC_0186	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XC_0191	COG1881	PFAM PEBP family protein
XC_0194	COG0174	glutamine synthetase
XC_0195	COG0347	Belongs to the P(II) protein family
XC_0196	COG0004	ammonium transporteR
XC_0197	COG3852	Histidine kinase
XC_0198	COG2204	response regulator
XC_0200	COG2032	superoxide dismutase activity
XC_0201	COG2032	superoxide dismutase activity
XC_0202	COG0346	lactoylglutathione lyase activity
XC_0204	COG0183	Belongs to the thiolase family
XC_0212	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XC_0216	COG0028	Belongs to the TPP enzyme family
XC_0219	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XC_0222	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XC_0223	COG3177	Filamentation induced by cAMP protein fic
XC_0226	COG0596	Alpha beta hydrolase
XC_0228	COG0318	PFAM AMP-dependent synthetase and ligase
XC_0229	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XC_0232	COG1181	Belongs to the D-alanine--D-alanine ligase family
XC_0235	COG0564	pseudouridine synthase activity
XC_0239	COG1446	asparaginase
XC_0240	COG0339	signal peptide processing
XC_0246	COG0583	DNA-binding transcription factor activity
XC_0247	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XC_0248	COG2224	Isocitrate lyase
XC_0249	COG3706	GGDEF domain
XC_0255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XC_0256	COG1960	acyl-CoA dehydrogenase activity
XC_0269	COG0697	spore germination
XC_0271	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XC_0273	COG1846	Transcriptional regulator
XC_0274	COG1764	response to oxidative stress
XC_0279	COG0656	L-ascorbic acid biosynthetic process
XC_0280	COG2130	NADP-dependent
XC_0283	COG1187	pseudouridine synthase activity
XC_0285	COG1643	Atp-dependent helicase
XC_0286	COG0840	transmembrane signaling receptor activity
XC_0287	COG4807	Protein conserved in bacteria
XC_0288	COG2351	hydroxyisourate hydrolase activity
XC_0289	COG2072	flavoprotein involved in K transport
XC_0293	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XC_0299	COG3568	Endonuclease Exonuclease Phosphatase
XC_0300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XC_0303	COG1957	nucleoside hydrolase
XC_0305	COG2252	PERMEase
XC_0310	COG0084	hydrolase, TatD family'
XC_0312	COG0583	DNA-binding transcription factor activity
XC_0313	COG2814	Major facilitator Superfamily
XC_0319	COG1902	pentaerythritol trinitrate reductase activity
XC_0324	COG0300	oxidoreductase activity
XC_0326	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XC_0327	COG0583	DNA-binding transcription factor activity
XC_0330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
XC_0333	COG0702	epimerase
XC_0334	COG1733	regulation of RNA biosynthetic process
XC_0336	COG0840	transmembrane signaling receptor activity
XC_0360	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XC_0371	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XC_0376	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XC_0377	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XC_0379	COG3485	protocatechuate 3,4-dioxygenase
XC_0380	COG3485	protocatechuate 3,4-dioxygenase
XC_0382	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XC_0383	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XC_0385	COG1414	Transcriptional regulator
XC_0391	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
XC_0401	COG1040	competence protein
XC_0403	COG0582	viral genome integration into host DNA
XC_0405	COG4774	siderophore transport
XC_0407	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XC_0409	COG4206	TonB-dependent receptor
XC_0412	COG2963	transposase activity
XC_0413	COG2801	Transposase and inactivated derivatives
XC_0415	COG1511	domain protein
XC_0415	COG3264	Mechanosensitive ion channel
XC_0416	COG1368	sulfuric ester hydrolase activity
XC_0417	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XC_0418	COG2354	Protein conserved in bacteria
XC_0423	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XC_0428	COG0702	epimerase
XC_0435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XC_0436	COG1028	Short-chain dehydrogenase reductase Sdr
XC_0438	COG0513	Belongs to the DEAD box helicase family
XC_0439	COG3039	Transposase
XC_0440	COG3039	Transposase
XC_0441	COG0508	dehydrogenase complex catalyzes the overall conversion of
XC_0444	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
XC_0447	COG3104	oligopeptide transport
XC_0451	COG2852	Protein conserved in bacteria
XC_0455	COG1320	monovalent cation:proton antiporter activity
XC_0456	COG2212	antiporter activity
XC_0458	COG0651	ATP synthesis coupled electron transport
XC_0459	COG1006	Multisubunit Na H antiporter MnhC subunit
XC_0460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XC_0460	COG2111	Na H antiporter
XC_0474	COG0436	Aminotransferase
XC_0476	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XC_0482	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
XC_0488	COG2076	Multidrug Resistance protein
XC_0490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XC_0501	COG2816	NAD+ diphosphatase activity
XC_0502	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XC_0507	COG2814	Major facilitator Superfamily
XC_0508	COG1289	transmembrane transporter activity
XC_0509	COG0151	Belongs to the GarS family
XC_0511	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XC_0512	COG2267	carboxylic ester hydrolase activity
XC_0513	COG0671	phosphoesterase, PA-phosphatase related
XC_0513	COG2453	phosphatase
XC_0518	COG4589	Belongs to the CDS family
XC_0520	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XC_0527	COG0439	Biotin carboxylase
XC_0529	COG0511	ligase activity, forming carbon-carbon bonds
XC_0532	COG1324	tolerance protein
XC_0533	COG2356	endonuclease I
XC_0534	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
XC_0536	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
XC_0538	COG1196	nuclear chromosome segregation
XC_0545	COG2963	transposase activity
XC_0548	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XC_0553	COG3386	PFAM SMP-30 Gluconolaconase
XC_0557	COG3712	iron ion homeostasis
XC_0564	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XC_0568	COG0778	Nitroreductase
XC_0569	COG2353	YceI-like domain
XC_0577	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
XC_0580	COG1802	Transcriptional regulator
XC_0597	COG0435	Glutathione S-transferase
XC_0609	COG2409	Drug exporters of the RND superfamily
XC_0611	COG0823	Involved in the tonB-independent uptake of proteins
XC_0611	COG1506	peptidase
XC_0613	COG3706	GGDEF domain
XC_0614	COG1959	2 iron, 2 sulfur cluster binding
XC_0622	COG0697	spore germination
XC_0625	COG4305	rare lipoprotein A
XC_0626	COG5297	Belongs to the glycosyl hydrolase family 6
XC_0627	COG1113	amino acid transport
XC_0628	COG0598	Magnesium transport protein CorA
XC_0637	COG3447	MASE1 domain protein
XC_0637	COG5001	Diguanylate cyclase
XC_0637	COG5002	protein histidine kinase activity
XC_0638	COG0840	transmembrane signaling receptor activity
XC_0639	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XC_0639	COG5297	Belongs to the glycosyl hydrolase family 6
XC_0640	COG0659	secondary active sulfate transmembrane transporter activity
XC_0641	COG3706	GGDEF domain
XC_0644	COG3273	potassium ion transport
XC_0644	COG0471	metal ion transport
XC_0647	COG3275	phosphorelay sensor kinase activity
XC_0654	COG1505	serine-type exopeptidase activity
XC_0660	COG2832	Protein of unknown function (DUF454)
XC_0666	COG2963	transposase activity
XC_0673	COG2226	methyltransferase
XC_0675	COG5001	Diguanylate cyclase
XC_0675	COG3300	MHYT domain
XC_0676	COG0308	aminopeptidase N
XC_0680	COG2963	transposase activity
XC_0686	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
XC_0689	COG3284	Transcriptional regulator
XC_0691	COG1077	Cell shape determining protein MreB Mrl
XC_0692	COG1792	Involved in formation and maintenance of cell shape
XC_0695	COG0772	Belongs to the SEDS family
XC_0697	COG2963	transposase activity
XC_0706	COG2951	lytic endotransglycosylase activity
XC_0707	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XC_0708	COG1686	Belongs to the peptidase S11 family
XC_0711	COG2921	Belongs to the UPF0250 family
XC_0718	COG1056	cytidyltransferase-related domain
XC_0718	COG1051	belongs to the nudix hydrolase family
XC_0725	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XC_0726	COG0673	inositol 2-dehydrogenase activity
XC_0727	COG2823	Periplasmic or secreted lipoprotein
XC_0728	COG4251	negative regulation of phosphorylation
XC_0729	COG0784	Response regulator, receiver
XC_0730	COG4191	Histidine kinase
XC_0731	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XC_0733	COG1028	Short-chain dehydrogenase reductase Sdr
XC_0741	COG1459	type II secretion system
XC_0745	COG4795	General secretion pathway protein
XC_0750	COG2188	Transcriptional regulator
XC_0752	COG1609	Transcriptional regulator
XC_0753	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XC_0754	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XC_0762	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XC_0764	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XC_0769	COG2205	protein histidine kinase activity
XC_0770	COG0745	RESPONSE REGULATOR receiver
XC_0773	COG0583	DNA-binding transcription factor activity
XC_0777	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
XC_0778	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XC_0780	COG0697	spore germination
XC_0782	COG1307	EDD domain protein, DegV family
XC_0792	COG0402	S-adenosylhomocysteine deaminase activity
XC_0796	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XC_0800	COG0436	Aminotransferase
XC_0807	COG2211	Major facilitator Superfamily
XC_0808	COG1609	Transcriptional regulator
XC_0809	COG1028	Short-chain dehydrogenase reductase Sdr
XC_0810	COG2851	Citrate transporter
XC_0813	COG0642	Histidine kinase
XC_0814	COG1840	ABC-type Fe3 transport system, periplasmic component
XC_0816	COG2197	response regulator
XC_0818	COG4191	Histidine kinase
XC_0826	COG1560	Kdo2-lipid A biosynthetic process
XC_0827	COG1519	Transferase
XC_0828	COG1538	Outer membrane efflux protein
XC_0829	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XC_0831	COG5001	Diguanylate cyclase
XC_0831	COG3300	MHYT domain
XC_0835	COG2226	methyltransferase
XC_0842	COG0405	Gamma-glutamyltransferase
XC_0843	COG0840	transmembrane signaling receptor activity
XC_0844	COG1506	peptidase
XC_0844	COG4946	Tricorn protease homolog
XC_0844	COG0823	Involved in the tonB-independent uptake of proteins
XC_0847	COG3710	Transcriptional regulator
XC_0851	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XC_0853	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XC_0859	COG2963	transposase activity
XC_0862	COG3039	Transposase
XC_0874	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XC_0876	COG3781	membrane
XC_0877	COG0671	phosphoesterase, PA-phosphatase related
XC_0879	COG1028	Short-chain dehydrogenase reductase Sdr
XC_0881	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XC_0882	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XC_0889	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XC_0896	COG1773	rubredoxin
XC_0897	COG2912	Transglutaminase-like superfamily
XC_0901	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XC_0904	COG3079	Belongs to the UPF0149 family
XC_0905	COG0006	proline dipeptidase activity
XC_0907	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XC_0907	COG3453	Protein conserved in bacteria
XC_0910	COG0725	ABC transporter, periplasmic molybdate-binding protein
XC_0911	COG4149	molybdate abc transporter
XC_0920	COG1376	ErfK ybiS ycfS ynhG family protein
XC_0921	COG0739	heme binding
XC_0922	COG1028	Short-chain dehydrogenase reductase Sdr
XC_0923	COG0583	DNA-binding transcription factor activity
XC_0924	COG4773	Receptor
XC_0925	COG4773	Receptor
XC_0926	COG2963	transposase activity
XC_0927	COG2801	Transposase and inactivated derivatives
XC_0928	COG0596	Alpha beta hydrolase
XC_0929	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XC_0930	COG1301	dicarboxylic acid transport
XC_0932	COG2304	oxidoreductase activity
XC_0936	COG0714	Associated with various cellular activities
XC_0942	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XC_0947	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XC_0949	COG2721	sulfolactate sulfo-lyase activity
XC_0952	COG2271	Major facilitator Superfamily
XC_0955	COG0583	DNA-binding transcription factor activity
XC_0956	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XC_0957	COG1758	RNA polymerase activity
XC_0959	COG1561	YicC-like family, N-terminal region
XC_0961	COG0346	lactoylglutathione lyase activity
XC_0963	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XC_0969	COG3047	cAMP biosynthetic process
XC_0972	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XC_0978	COG0469	pyruvate kinase activity
XC_0979	COG3588	fructose-bisphosphate aldolase
XC_0980	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
XC_0987	COG0784	Response regulator, receiver
XC_0987	COG2205	protein histidine kinase activity
XC_0987	COG2198	Histidine kinase
XC_0992	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XC_0994	COG2895	sulfate adenylyltransferase (ATP) activity
XC_0994	COG0529	Catalyzes the synthesis of activated sulfate
XC_0995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XC_0996	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XC_0997	COG0308	aminopeptidase N
XC_0999	COG1115	amino acid carrier protein
XC_1000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XC_1001	COG2272	Belongs to the type-B carboxylesterase lipase family
XC_1002	COG4948	Mandelate Racemase Muconate Lactonizing
XC_1003	COG3250	beta-galactosidase activity
XC_1005	COG5297	Belongs to the glycosyl hydrolase family 6
XC_1006	COG1609	Transcriptional regulator
XC_1013	COG3273	potassium ion transport
XC_1013	COG0471	metal ion transport
XC_1018	COG0582	viral genome integration into host DNA
XC_1021	COG1396	sequence-specific DNA binding
XC_1022	COG0583	DNA-binding transcription factor activity
XC_1025	COG2801	Transposase and inactivated derivatives
XC_1026	COG2963	transposase activity
XC_1032	COG2801	Transposase and inactivated derivatives
XC_1034	COG2963	transposase activity
XC_1036	COG5001	Diguanylate cyclase
XC_1049	COG0745	RESPONSE REGULATOR receiver
XC_1056	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XC_1057	COG1459	type II secretion system
XC_1067	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XC_1067	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XC_1069	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XC_1070	COG0564	pseudouridine synthase activity
XC_1074	COG0840	transmembrane signaling receptor activity
XC_1077	COG3387	PFAM Glycoside hydrolase 15-related
XC_1078	COG1877	trehalose-phosphatase activity
XC_1087	COG1116	anion transmembrane transporter activity
XC_1088	COG0542	response to heat
XC_1091	COG4206	TonB-dependent receptor
XC_1095	COG1797	cobyrinic acid a,c-diamide synthase activity
XC_1096	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XC_1101	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
XC_1103	COG0019	diaminopimelate decarboxylase activity
XC_1104	COG4264	IucA IucC family
XC_1105	COG2814	Major facilitator Superfamily
XC_1106	COG4264	IucA IucC family
XC_1108	COG4772	TonB-dependent receptor
XC_1110	COG4651	solute:proton antiporter activity
XC_1110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XC_1116	COG0488	(ABC) transporter
XC_1120	COG2755	lipolytic protein G-D-S-L family
XC_1120	COG0657	acetylesterase activity
XC_1124	COG0477	Major facilitator Superfamily
XC_1137	COG0824	Thioesterase
XC_1139	COG0848	biopolymer transport protein
XC_1142	COG2885	chlorophyll binding
XC_1144	COG0602	queuosine metabolic process
XC_1152	COG0038	chloride channel
XC_1153	COG0583	DNA-binding transcription factor activity
XC_1158	COG1187	pseudouridine synthase activity
XC_1162	COG0514	ATP-dependent DNA helicase (RecQ)
XC_1163	COG0783	Belongs to the Dps family
XC_1164	COG1643	Atp-dependent helicase
XC_1173	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XC_1175	COG1215	transferase activity, transferring glycosyl groups
XC_1176	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XC_1178	COG1199	ATP-dependent helicase activity
XC_1180	COG1397	ADP-ribosylglycohydrolase
XC_1182	COG0189	ligase activity
XC_1185	COG0835	chemotaxis
XC_1186	COG0840	transmembrane signaling receptor activity
XC_1193	COG1595	DNA-templated transcription, initiation
XC_1194	COG2304	oxidoreductase activity
XC_1195	COG1446	asparaginase
XC_1204	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XC_1206	COG3645	SOS response
XC_1211	COG2963	transposase activity
XC_1215	COG3537	Alpha-1,2-mannosidase
XC_1217	COG1472	Belongs to the glycosyl hydrolase 3 family
XC_1219	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XC_1220	COG1388	LysM domain
XC_1220	COG3858	chitin binding
XC_1223	COG0837	glucose binding
XC_1224	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XC_1226	COG0494	nUDIX hydrolase
XC_1227	COG1218	3'(2'),5'-bisphosphate nucleotidase
XC_1228	COG3956	TIGRFAM MazG family protein
XC_1230	COG0330	HflC and HflK could
XC_1238	COG1960	acyl-CoA dehydrogenase activity
XC_1240	COG1309	transcriptional regulator
XC_1243	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XC_1245	COG0463	Glycosyl transferase, family 2
XC_1246	COG0516	GMP reductase activity
XC_1246	COG0517	IMP dehydrogenase activity
XC_1247	COG2982	Protein involved in outer membrane biogenesis
XC_1248	COG1272	protein, Hemolysin III
XC_1251	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XC_1252	COG0626	cystathionine gamma-synthase activity
XC_1253	COG0460	homoserine dehydrogenase
XC_1253	COG0527	aspartate kinase activity
XC_1255	COG1760	l-serine dehydratase
XC_1259	COG2353	YceI-like domain
XC_1263	COG0477	Major facilitator Superfamily
XC_1272	COG1842	Phage shock protein A
XC_1277	COG0754	glutathionylspermidine amidase activity
XC_1290	COG2201	protein-glutamate methylesterase activity
XC_1293	COG0531	amino acid
XC_1295	COG2197	response regulator
XC_1299	COG1113	amino acid transport
XC_1300	COG1271	oxidase subunit
XC_1301	COG1294	oxidase, subunit
XC_1303	COG2239	Acts as a magnesium transporter
XC_1304	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XC_1305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XC_1309	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XC_1312	COG1137	ATPase activity
XC_1315	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XC_1317	COG0271	Belongs to the BolA IbaG family
XC_1322	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XC_1326	COG0628	permease
XC_1328	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XC_1331	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XC_1332	COG1555	photosystem II stabilization
XC_1341	COG4774	siderophore transport
XC_1342	COG2146	nitrite reductase [NAD(P)H] activity
XC_1344	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XC_1345	COG0719	Fe-S assembly protein
XC_1346	COG0396	ATPase activity
XC_1347	COG0719	Fe-S assembly protein
XC_1350	COG0693	protein deglycase activity
XC_1357	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XC_1363	COG0519	Catalyzes the synthesis of GMP from XMP
XC_1364	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
XC_1368	COG1764	response to oxidative stress
XC_1370	COG0384	phenazine biosynthesis protein PhzF
XC_1371	COG0384	phenazine biosynthesis protein PhzF
XC_1372	COG0527	aspartate kinase activity
XC_1377	COG0142	geranyltranstransferase activity
XC_1378	COG0629	single-stranded DNA binding
XC_1380	COG1401	restriction endodeoxyribonuclease activity
XC_1383	COG2203	Gaf domain
XC_1383	COG3706	GGDEF domain
XC_1383	COG5001	Diguanylate cyclase
XC_1383	COG4251	negative regulation of phosphorylation
XC_1384	COG0604	alcohol dehydrogenase
XC_1385	COG2080	2 iron, 2 sulfur cluster binding
XC_1386	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XC_1387	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XC_1388	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
XC_1389	COG0746	molybdenum cofactor guanylyltransferase activity
XC_1397	COG2879	small protein
XC_1398	COG1966	Carbon starvation protein
XC_1399	COG1741	Belongs to the pirin family
XC_1402	COG1741	Belongs to the pirin family
XC_1406	COG3590	peptidase
XC_1407	COG3039	Transposase
XC_1408	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XC_1410	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XC_1411	COG2202	Pas domain
XC_1411	COG2200	EAL domain
XC_1411	COG2199	diguanylate cyclase activity
XC_1412	COG0835	chemotaxis
XC_1413	COG0840	transmembrane signaling receptor activity
XC_1414	COG2198	Histidine kinase
XC_1414	COG0643	Histidine kinase
XC_1416	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XC_1418	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XC_1419	COG0745	RESPONSE REGULATOR receiver
XC_1421	COG2205	protein histidine kinase activity
XC_1423	COG4452	Inner membrane protein CreD
XC_1430	COG0735	belongs to the Fur family
XC_1433	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XC_1434	COG1538	Outer membrane efflux protein
XC_1435	COG1309	transcriptional regulator
XC_1436	COG0667	Aldo Keto reductase
XC_1439	COG2207	Transcriptional regulator
XC_1443	COG0583	DNA-binding transcription factor activity
XC_1444	COG2814	Major facilitator Superfamily
XC_1445	COG0667	Aldo Keto reductase
XC_1450	COG1404	Belongs to the peptidase S8 family
XC_1452	COG3383	formate dehydrogenase (NAD+) activity
XC_1454	COG1271	oxidase subunit
XC_1455	COG1294	oxidase, subunit
XC_1470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XC_1476	COG5001	Diguanylate cyclase
XC_1476	COG5002	protein histidine kinase activity
XC_1477	COG1187	pseudouridine synthase activity
XC_1481	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
XC_1483	COG0475	glutathione-regulated potassium exporter activity
XC_1484	COG1132	(ABC) transporter
XC_1493	COG2155	Conserved Protein
XC_1495	COG3118	belongs to the thioredoxin family
XC_1500	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XC_1505	COG2968	Membrane
XC_1507	COG1530	ribonuclease E activity
XC_1508	COG3164	Protein of unknown function
XC_1510	COG0312	modulator of DNA gyrase
XC_1512	COG0312	modulator of DNA gyrase
XC_1514	COG4104	PAAR repeat-containing protein
XC_1516	COG0142	geranyltranstransferase activity
XC_1519	COG1785	Belongs to the alkaline phosphatase family
XC_1520	COG1301	dicarboxylic acid transport
XC_1521	COG4106	trans-aconitate 2-methyltransferase activity
XC_1526	COG4191	Histidine kinase
XC_1527	COG3284	Transcriptional regulator
XC_1534	COG0791	NLP P60 protein
XC_1535	COG0791	NLP P60 protein
XC_1536	COG1047	Peptidyl-prolyl cis-trans
XC_1537	COG2311	Membrane
XC_1538	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XC_1539	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XC_1543	COG3590	peptidase
XC_1544	COG3590	peptidase
XC_1547	COG0489	protein tyrosine kinase activity
XC_1552	COG0412	Dienelactone hydrolase
XC_1555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XC_1559	COG0494	nUDIX hydrolase
XC_1560	COG0433	COG0433 Predicted ATPase
XC_1565	COG2890	protein-(glutamine-N5) methyltransferase activity
XC_1568	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XC_1569	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XC_1586	COG4221	oxidoreductase activity
XC_1589	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XC_1593	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XC_1594	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XC_1598	COG0839	Belongs to the complex I subunit 6 family
XC_1599	COG0713	ATP synthesis coupled electron transport
XC_1602	COG1007	ATP synthesis coupled electron transport
XC_1604	COG0195	Participates in both transcription termination and antitermination
XC_1605	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XC_1616	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XC_1618	COG2095	MarC family integral membrane protein
XC_1620	COG1611	Belongs to the LOG family
XC_1621	COG4969	Belongs to the N-Me-Phe pilin family
XC_1627	COG4969	Belongs to the N-Me-Phe pilin family
XC_1630	COG3505	Type IV secretory pathway VirD4
XC_1634	COG2948	multi-organism process
XC_1638	COG3702	type iv secretory pathway
XC_1642	COG0366	Alpha amylase catalytic
XC_1643	COG3039	Transposase
XC_1645	COG1082	Xylose isomerase domain protein TIM barrel
XC_1651	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XC_1652	COG0291	Belongs to the bacterial ribosomal protein bL35 family
XC_1656	COG0776	regulation of translation
XC_1664	COG0438	transferase activity, transferring glycosyl groups
XC_1665	COG0438	transferase activity, transferring glycosyl groups
XC_1666	COG2244	polysaccharide biosynthetic process
XC_1672	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XC_1674	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XC_1680	COG1960	acyl-CoA dehydrogenase activity
XC_1684	COG0322	excinuclease ABC activity
XC_1689	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XC_1691	COG0784	Response regulator, receiver
XC_1691	COG4191	Histidine kinase
XC_1695	COG0552	protein localization to endoplasmic reticulum
XC_1697	COG3938	Belongs to the proline racemase family
XC_1701	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XC_1703	COG0006	proline dipeptidase activity
XC_1706	COG0531	amino acid
XC_1712	COG4206	TonB-dependent receptor
XC_1714	COG3507	Belongs to the glycosyl hydrolase 43 family
XC_1715	COG1506	peptidase
XC_1715	COG0823	Involved in the tonB-independent uptake of proteins
XC_1722	COG0742	ribosomal rna small subunit methyltransferase
XC_1725	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XC_1726	COG0405	Gamma-glutamyltransferase
XC_1727	COG3291	Pkd domain containing protein
XC_1733	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XC_1737	COG1862	Preprotein translocase
XC_1739	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XC_1742	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XC_1742	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XC_1743	COG1105	Belongs to the carbohydrate kinase PfkB family
XC_1744	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XC_1744	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XC_1745	COG1609	Transcriptional regulator
XC_1747	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XC_1748	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XC_1751	COG2902	Dehydrogenase
XC_1752	COG1609	Transcriptional regulator
XC_1752	COG2207	Transcriptional regulator
XC_1753	COG1335	isochorismatase
XC_1754	COG0477	Major facilitator Superfamily
XC_1756	COG2205	protein histidine kinase activity
XC_1756	COG0784	Response regulator, receiver
XC_1756	COG5002	protein histidine kinase activity
XC_1757	COG2733	membrane
XC_1762	COG0243	molybdopterin cofactor binding
XC_1764	COG0477	Major facilitator Superfamily
XC_1765	COG2703	oxygen carrier activity
XC_1766	COG0745	RESPONSE REGULATOR receiver
XC_1766	COG3706	GGDEF domain
XC_1767	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XC_1768	COG0174	glutamine synthetase
XC_1769	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XC_1776	COG3842	ATPase activity
XC_1777	COG1176	ABC-type spermidine putrescine transport system, permease component I
XC_1778	COG1177	transmembrane transport
XC_1780	COG1012	belongs to the aldehyde dehydrogenase family
XC_1783	COG4535	Mg2 and Co2 transporter CorC
XC_1787	COG1702	phosphate starvation-inducible protein PhoH
XC_1791	COG0741	lytic transglycosylase activity
XC_1792	COG0723	plastoquinol--plastocyanin reductase activity
XC_1793	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XC_1794	COG2857	Cytochrome c1
XC_1795	COG0625	glutathione transferase activity
XC_1796	COG2969	positive regulation of protein catabolic process
XC_1799	COG1201	RNA secondary structure unwinding
XC_1801	COG0840	transmembrane signaling receptor activity
XC_1802	COG0835	chemotaxis
XC_1810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XC_1813	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XC_1814	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XC_1814	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XC_1816	COG0860	N-Acetylmuramoyl-L-alanine amidase
XC_1821	COG1028	Short-chain dehydrogenase reductase Sdr
XC_1824	COG5001	Diguanylate cyclase
XC_1824	COG3300	MHYT domain
XC_1825	COG2081	HI0933 family
XC_1826	COG4681	YaeQ
XC_1833	COG0513	Belongs to the DEAD box helicase family
XC_1838	COG0483	inositol monophosphate 1-phosphatase activity
XC_1841	COG5001	Diguanylate cyclase
XC_1841	COG3300	MHYT domain
XC_1842	COG1509	lysine 2,3-aminomutase activity
XC_1845	COG0402	S-adenosylhomocysteine deaminase activity
XC_1850	COG4677	pectinesterase activity
XC_1858	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XC_1861	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XC_1866	COG2166	iron-sulfur cluster assembly
XC_1869	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XC_1871	COG0137	argininosuccinate synthase activity
XC_1873	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XC_1884	COG1294	oxidase, subunit
XC_1886	COG4988	ABC transporter
XC_1887	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XC_1899	COG0436	Aminotransferase
XC_1904	COG1187	pseudouridine synthase activity
XC_1905	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XC_1906	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XC_1907	COG2350	Protein conserved in bacteria
XC_1912	COG2182	Extracellular solute-binding protein
XC_1914	COG0395	ABC-type sugar transport system, permease component
XC_1919	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XC_1920	COG2957	Belongs to the agmatine deiminase family
XC_1922	COG0257	Belongs to the bacterial ribosomal protein bL36 family
XC_1924	COG0539	negative regulation of cytoplasmic translation
XC_1927	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XC_1930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XC_1931	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XC_1931	COG0475	glutathione-regulated potassium exporter activity
XC_1938	COG2197	response regulator
XC_1941	COG1335	isochorismatase
XC_1944	COG2814	Major facilitator Superfamily
XC_1947	COG1914	H( )-stimulated, divalent metal cation uptake system
XC_1948	COG1321	iron dependent repressor
XC_1949	COG0590	tRNA wobble adenosine to inosine editing
XC_1951	COG0668	transmembrane transport
XC_1956	COG1028	Short-chain dehydrogenase reductase Sdr
XC_1957	COG1183	phosphatidylcholine synthase activity
XC_1959	COG3243	poly(R)-hydroxyalkanoic acid synthase
XC_1962	COG0723	plastoquinol--plastocyanin reductase activity
XC_1962	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XC_1964	COG2183	response to ionizing radiation
XC_1965	COG5001	Diguanylate cyclase
XC_1973	COG0800	Aldolase
XC_1974	COG0129	dihydroxy-acid dehydratase activity
XC_1975	COG0363	glucosamine-6-phosphate deaminase activity
XC_1977	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XC_1980	COG0354	folic acid binding
XC_1982	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XC_1983	COG1053	succinate dehydrogenase
XC_1985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XC_1988	COG4591	ABC-type transport system involved in lipoprotein release permease component
XC_1993	COG0811	peptide transport
XC_1998	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XC_2001	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XC_2002	COG0582	viral genome integration into host DNA
XC_2010	COG2963	transposase activity
XC_2012	COG3039	Transposase
XC_2029	COG2003	Belongs to the UPF0758 family
XC_2063	COG0270	DNA (cytosine-5-)-methyltransferase activity
XC_2064	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XC_2065	COG0629	single-stranded DNA binding
XC_2071	COG1192	Involved in chromosome partitioning
XC_2078	COG1061	Type III restriction enzyme res subunit
XC_2079	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XC_2082	COG5599	Phosphatase
XC_2084	COG4644	lycopene metabolic process
XC_2091	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XC_2098	COG1530	ribonuclease E activity
XC_2100	COG0428	transporter
XC_2128	COG3459	Glycosyltransferase 36 associated
XC_2130	COG4191	Histidine kinase
XC_2130	COG0784	Response regulator, receiver
XC_2136	COG0840	transmembrane signaling receptor activity
XC_2138	COG1238	metal cluster binding
XC_2142	COG1733	regulation of RNA biosynthetic process
XC_2145	COG1999	signal sequence binding
XC_2148	COG3590	peptidase
XC_2161	COG5001	Diguanylate cyclase
XC_2163	COG2201	protein-glutamate methylesterase activity
XC_2164	COG3685	Protein conserved in bacteria
XC_2167	COG0579	oxidoreductase
XC_2169	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XC_2171	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
XC_2175	COG0243	molybdopterin cofactor binding
XC_2177	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XC_2178	COG2223	nitrite transmembrane transporter activity
XC_2179	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XC_2181	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XC_2181	COG1648	precorrin-2 dehydrogenase activity
XC_2183	COG0746	molybdenum cofactor guanylyltransferase activity
XC_2184	COG0303	'Molybdopterin
XC_2186	COG0708	Exodeoxyribonuclease III
XC_2191	COG2124	cytochrome p450
XC_2192	COG1028	Short-chain dehydrogenase reductase Sdr
XC_2195	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XC_2198	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XC_2203	COG0105	UTP biosynthetic process
XC_2205	COG1250	3-hydroxyacyl-CoA dehydrogenase
XC_2205	COG1024	Enoyl-CoA hydratase
XC_2206	COG0183	Belongs to the thiolase family
XC_2208	COG0038	chloride channel
XC_2209	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XC_2213	COG1674	ftsk spoiiie
XC_2214	COG0492	ferredoxin-NADP+ reductase activity
XC_2218	COG0542	response to heat
XC_2222	COG2915	High frequency lysogenization protein hflD homolog
XC_2229	COG4191	Histidine kinase
XC_2233	COG0784	Response regulator, receiver
XC_2233	COG0835	chemotaxis
XC_2235	COG1558	bacterial-type flagellum-dependent cell motility
XC_2236	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XC_2237	COG1749	Flagellar hook protein flgE
XC_2238	COG4787	bacterial-type flagellum-dependent cell motility
XC_2239	COG4786	Flagellar basal body rod
XC_2242	COG3951	Flagellar rod assembly protein muramidase FlgJ
XC_2242	COG1705	Flagellar rod assembly protein muramidase FlgJ
XC_2244	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XC_2245	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XC_2246	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
XC_2252	COG2201	protein-glutamate methylesterase activity
XC_2253	COG2204	response regulator
XC_2258	COG0438	transferase activity, transferring glycosyl groups
XC_2258	COG1216	Glycosyl transferase, family 2
XC_2259	COG1677	Flagellar hook-basal body complex protein FliE
XC_2272	COG1987	bacterial-type flagellum assembly
XC_2273	COG1684	flagellar biosynthetic protein fliR
XC_2274	COG3300	MHYT domain
XC_2274	COG5001	Diguanylate cyclase
XC_2280	COG0455	bacterial-type flagellum organization
XC_2284	COG2198	Histidine kinase
XC_2284	COG0643	Histidine kinase
XC_2295	COG0672	)-iron permease
XC_2297	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XC_2298	COG1360	Flagellar Motor Protein
XC_2299	COG1192	Involved in chromosome partitioning
XC_2300	COG0835	chemotaxis
XC_2302	COG0745	RESPONSE REGULATOR receiver
XC_2304	COG0840	transmembrane signaling receptor activity
XC_2307	COG0840	transmembrane signaling receptor activity
XC_2308	COG0840	transmembrane signaling receptor activity
XC_2309	COG0840	transmembrane signaling receptor activity
XC_2311	COG0840	transmembrane signaling receptor activity
XC_2313	COG0840	transmembrane signaling receptor activity
XC_2314	COG0840	transmembrane signaling receptor activity
XC_2316	COG0840	transmembrane signaling receptor activity
XC_2318	COG0835	chemotaxis
XC_2320	COG0840	transmembrane signaling receptor activity
XC_2323	COG2201	protein-glutamate methylesterase activity
XC_2325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XC_2331	COG0318	PFAM AMP-dependent synthetase and ligase
XC_2332	COG1024	Enoyl-CoA hydratase
XC_2337	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XC_2338	COG3279	Response regulator of the LytR AlgR family
XC_2343	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XC_2345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XC_2346	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XC_2348	COG0505	Belongs to the CarA family
XC_2350	COG2258	MOSC domain
XC_2351	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XC_2356	COG1024	Enoyl-CoA hydratase
XC_2363	COG0277	FAD linked oxidase domain protein
XC_2364	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XC_2367	COG0531	amino acid
XC_2368	COG0531	amino acid
XC_2374	COG0140	phosphoribosyl-ATP diphosphatase activity
XC_2374	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XC_2384	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XC_2386	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
XC_2390	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
XC_2395	COG2963	transposase activity
XC_2400	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
XC_2400	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
XC_2405	COG2814	Major facilitator Superfamily
XC_2445	COG1012	belongs to the aldehyde dehydrogenase family
XC_2450	COG0697	spore germination
XC_2451	COG1794	racemase activity, acting on amino acids and derivatives
XC_2453	COG0477	Major facilitator Superfamily
XC_2454	COG0671	phosphoesterase, PA-phosphatase related
XC_2457	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XC_2458	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XC_2459	COG4251	negative regulation of phosphorylation
XC_2459	COG5001	Diguanylate cyclase
XC_2459	COG2203	Gaf domain
XC_2459	COG3706	GGDEF domain
XC_2461	COG1472	Belongs to the glycosyl hydrolase 3 family
XC_2472	COG0860	N-Acetylmuramoyl-L-alanine amidase
XC_2476	COG0477	Major facilitator Superfamily
XC_2478	COG1070	Carbohydrate kinase
XC_2480	COG1501	Belongs to the glycosyl hydrolase 31 family
XC_2487	COG0800	Aldolase
XC_2490	COG3734	2-keto-3-deoxy-galactonokinase
XC_2491	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XC_2493	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XC_2496	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XC_2497	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XC_2499	COG0351	phosphomethylpyrimidine kinase
XC_2499	COG0352	thiamine-phosphate diphosphorylase activity
XC_2502	COG0583	DNA-binding transcription factor activity
XC_2503	COG1741	Belongs to the pirin family
XC_2510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XC_2512	COG4771	TonB-dependent receptor
XC_2513	COG1546	Belongs to the CinA family
XC_2514	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XC_2517	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XC_2518	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XC_2520	COG1534	Rna-binding protein
XC_2523	COG1238	metal cluster binding
XC_2526	COG2840	Smr protein MutS2
XC_2537	COG2134	cdp-diacylglycerol pyrophosphatase
XC_2542	COG1253	flavin adenine dinucleotide binding
XC_2545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XC_2546	COG0477	Major facilitator Superfamily
XC_2547	COG1132	(ABC) transporter
XC_2551	COG0438	transferase activity, transferring glycosyl groups
XC_2552	COG0438	transferase activity, transferring glycosyl groups
XC_2559	COG2244	polysaccharide biosynthetic process
XC_2562	COG3038	cytochrome b561
XC_2566	COG1595	DNA-templated transcription, initiation
XC_2569	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XC_2573	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XC_2576	COG0784	Response regulator, receiver
XC_2576	COG4191	Histidine kinase
XC_2577	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XC_2586	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
XC_2593	COG2963	transposase activity
XC_2594	COG2801	Transposase and inactivated derivatives
XC_2597	COG2963	transposase activity
XC_2601	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XC_2604	COG2963	transposase activity
XC_2612	COG2003	Belongs to the UPF0758 family
XC_2622	COG3039	Transposase
XC_2624	COG2963	transposase activity
XC_2625	COG2963	transposase activity
XC_2626	COG2801	Transposase and inactivated derivatives
XC_2628	COG2801	Transposase and inactivated derivatives
XC_2629	COG2963	transposase activity
XC_2639	COG0583	DNA-binding transcription factor activity
XC_2642	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
XC_2644	COG1605	Chorismate mutase
XC_2644	COG0077	Prephenate dehydratase
XC_2646	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XC_2657	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XC_2659	COG4993	Dehydrogenase
XC_2663	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XC_2665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XC_2672	COG0316	Belongs to the HesB IscA family
XC_2678	COG0288	reversible hydration of carbon dioxide
XC_2683	COG2925	Exonuclease
XC_2698	COG0494	nUDIX hydrolase
XC_2700	COG1024	Enoyl-CoA hydratase
XC_2702	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XC_2703	COG0659	secondary active sulfate transmembrane transporter activity
XC_2708	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XC_2709	COG0573	inorganic phosphate transmembrane transporter activity
XC_2710	COG0581	inorganic phosphate transmembrane transporter activity
XC_2712	COG0704	Plays a role in the regulation of phosphate uptake
XC_2715	COG3706	GGDEF domain
XC_2716	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XC_2718	COG0557	exoribonuclease II activity
XC_2721	COG1960	acyl-CoA dehydrogenase activity
XC_2722	COG1960	acyl-CoA dehydrogenase activity
XC_2724	COG0646	methionine synthase
XC_2724	COG1410	methionine synthase
XC_2725	COG1410	methionine synthase
XC_2725	COG0646	methionine synthase
XC_2727	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XC_2729	COG1609	Transcriptional regulator
XC_2735	COG0386	Belongs to the glutathione peroxidase family
XC_2736	COG1725	Transcriptional regulator
XC_2737	COG1131	(ABC) transporter
XC_2743	COG1253	flavin adenine dinucleotide binding
XC_2747	COG2850	peptidyl-arginine hydroxylation
XC_2754	COG1132	(ABC) transporter
XC_2755	COG0583	DNA-binding transcription factor activity
XC_2756	COG2274	protein secretion by the type I secretion system
XC_2761	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XC_2764	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XC_2765	COG1420	regulation of RNA biosynthetic process
XC_2766	COG0497	DNA recombination
XC_2768	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XC_2772	COG1404	Belongs to the peptidase S8 family
XC_2785	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
XC_2793	COG3706	GGDEF domain
XC_2795	COG3706	GGDEF domain
XC_2797	COG1028	Short-chain dehydrogenase reductase Sdr
XC_2799	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XC_2801	COG0583	DNA-binding transcription factor activity
XC_2803	COG0415	Belongs to the DNA photolyase family
XC_2804	COG0305	Participates in initiation and elongation during chromosome replication
XC_2806	COG0367	asparagine synthase
XC_2809	COG1960	acyl-CoA dehydrogenase activity
XC_2812	COG0084	hydrolase, TatD family'
XC_2813	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XC_2825	COG0386	Belongs to the glutathione peroxidase family
XC_2826	COG0339	signal peptide processing
XC_2837	COG2814	Major facilitator Superfamily
XC_2838	COG1566	PFAM secretion protein HlyD family protein
XC_2846	COG4774	siderophore transport
XC_2848	COG0367	asparagine synthase
XC_2852	COG1393	Belongs to the ArsC family
XC_2856	COG0024	Methionine aminopeptidase
XC_2866	COG0745	RESPONSE REGULATOR receiver
XC_2866	COG3706	GGDEF domain
XC_2869	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XC_2870	COG0575	Belongs to the CDS family
XC_2872	COG0750	zinc metalloprotease
XC_2887	COG1695	Transcriptional regulator
XC_2892	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XC_2894	COG2040	homocysteine
XC_2895	COG0833	amino acid
XC_2897	COG0346	lactoylglutathione lyase activity
XC_2902	COG2878	Part of a membrane complex involved in electron transport
XC_2905	COG1595	DNA-templated transcription, initiation
XC_2910	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XC_2913	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XC_2914	COG0251	oxidation-reduction process
XC_2916	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XC_2916	COG0392	lysyltransferase activity
XC_2923	COG2814	Major facilitator Superfamily
XC_2924	COG1902	pentaerythritol trinitrate reductase activity
XC_2927	COG2824	Alkylphosphonate utilization operon protein PhnA
XC_2929	COG1047	Peptidyl-prolyl cis-trans
XC_2936	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XC_2938	COG5487	UPF0391 membrane protein
XC_2939	COG1451	nucleotide metabolic process
XC_2943	COG0183	Belongs to the thiolase family
XC_2946	COG3706	GGDEF domain
XC_2946	COG0745	RESPONSE REGULATOR receiver
XC_2949	COG1793	dna ligase
XC_2949	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XC_2951	COG1793	dna ligase
XC_2952	COG1201	RNA secondary structure unwinding
XC_2954	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XC_2955	COG1278	Cold shock
XC_2956	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XC_2959	COG3046	protein related to deoxyribodipyrimidine photolyase
XC_2960	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
XC_2960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XC_2961	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XC_2972	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XC_2978	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
XC_2979	COG1024	Enoyl-CoA hydratase
XC_2980	COG1960	acyl-CoA dehydrogenase activity
XC_2982	COG1396	sequence-specific DNA binding
XC_2982	COG3800	Transcriptional regulator
XC_2984	COG3867	Arabinogalactan endo-beta-1,4-galactanase
XC_2985	COG3250	beta-galactosidase activity
XC_2993	COG3039	Transposase
XC_3012	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XC_3023	COG5297	Belongs to the glycosyl hydrolase family 6
XC_3027	COG1309	transcriptional regulator
XC_3028	COG0436	Aminotransferase
XC_3035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XC_3039	COG0534	Mate efflux family protein
XC_3045	COG2070	2-Nitropropane dioxygenase
XC_3048	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XC_3051	COG3534	alpha-L-arabinofuranosidase
XC_3056	COG0784	Response regulator, receiver
XC_3056	COG4191	Histidine kinase
XC_3057	COG2205	protein histidine kinase activity
XC_3057	COG4999	Histidine kinase
XC_3057	COG3850	Histidine kinase
XC_3057	COG3437	response regulator, receiver
XC_3058	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XC_3060	COG2205	protein histidine kinase activity
XC_3061	COG5507	3-demethylubiquinone-9 3-methyltransferase
XC_3063	COG4771	TonB-dependent receptor
XC_3070	COG2172	sigma factor antagonist activity
XC_3071	COG1366	Belongs to the anti-sigma-factor antagonist family
XC_3072	COG1366	Belongs to the anti-sigma-factor antagonist family
XC_3073	COG1902	pentaerythritol trinitrate reductase activity
XC_3075	COG0326	Molecular chaperone. Has ATPase activity
XC_3076	COG2207	Transcriptional regulator
XC_3078	COG3152	Membrane
XC_3081	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XC_3082	COG1845	cytochrome c oxidase, subunit III
XC_3083	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XC_3088	COG0196	riboflavin kinase activity
XC_3094	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XC_3095	COG0824	Thioesterase
XC_3096	COG1024	Enoyl-CoA hydratase
XC_3097	COG1946	Acyl-CoA thioesterase
XC_3099	COG1595	DNA-templated transcription, initiation
XC_3112	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XC_3117	COG2197	response regulator
XC_3118	COG4585	Histidine kinase
XC_3122	COG2894	cell division
XC_3125	COG5002	protein histidine kinase activity
XC_3126	COG0745	RESPONSE REGULATOR receiver
XC_3134	COG2814	Major facilitator Superfamily
XC_3138	COG0656	L-ascorbic acid biosynthetic process
XC_3139	COG0753	catalase activity
XC_3141	COG2207	Transcriptional regulator
XC_3141	COG1917	Cupin 2, conserved barrel domain protein
XC_3144	COG1506	peptidase
XC_3144	COG0823	Involved in the tonB-independent uptake of proteins
XC_3146	COG1297	OPT oligopeptide transporter protein
XC_3151	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XC_3156	COG2080	2 iron, 2 sulfur cluster binding
XC_3157	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XC_3158	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XC_3167	COG1028	Short-chain dehydrogenase reductase Sdr
XC_3168	COG3537	Alpha-1,2-mannosidase
XC_3170	COG1028	Short-chain dehydrogenase reductase Sdr
XC_3171	COG3387	PFAM Glycoside hydrolase 15-related
XC_3173	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XC_3174	COG0328	RNA-DNA hybrid ribonuclease activity
XC_3174	COG0406	alpha-ribazole phosphatase activity
XC_3180	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XC_3183	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
XC_3192	COG0308	aminopeptidase N
XC_3195	COG0330	HflC and HflK could
XC_3196	COG0330	HflC and HflK could
XC_3200	COG0678	peroxiredoxin activity
XC_3202	COG4953	penicillin-binding protein 1C
XC_3207	COG2373	Large extracellular alpha-helical protein
XC_3212	COG3609	addiction module antidote protein, CC2985 family
XC_3216	COG3829	transcription factor binding
XC_3223	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XC_3224	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XC_3226	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XC_3227	COG1028	Short-chain dehydrogenase reductase Sdr
XC_3228	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XC_3231	COG1399	metal-binding, possibly nucleic acid-binding protein
XC_3237	COG0714	Associated with various cellular activities
XC_3241	COG0537	adenosine 5'-monophosphoramidase activity
XC_3243	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XC_3245	COG0314	molybdopterin synthase activity
XC_3246	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XC_3250	COG1234	tRNA 3'-trailer cleavage
XC_3252	COG0859	PFAM glycosyl transferase family 9
XC_3254	COG0631	protein serine/threonine phosphatase activity
XC_3255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XC_3261	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XC_3268	COG0473	3-isopropylmalate dehydrogenase activity
XC_3271	COG4783	chaperone-mediated protein folding
XC_3272	COG0745	RESPONSE REGULATOR receiver
XC_3274	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XC_3276	COG0438	transferase activity, transferring glycosyl groups
XC_3277	COG0671	phosphoesterase, PA-phosphatase related
XC_3280	COG3291	Pkd domain containing protein
XC_3281	COG2833	Protein of unknown function (DUF455)
XC_3285	COG0285	dihydrofolate synthase activity
XC_3287	COG0406	alpha-ribazole phosphatase activity
XC_3292	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XC_3293	COG4208	sulfate ABC transporter
XC_3294	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XC_3295	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XC_3302	COG0446	pyridine nucleotide-disulphide oxidoreductase
XC_3302	COG1902	pentaerythritol trinitrate reductase activity
XC_3306	COG0625	glutathione transferase activity
XC_3308	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XC_3311	COG0154	amidase activity
XC_3313	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XC_3316	COG0202	RNA polymerase activity
XC_3317	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XC_3318	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
XC_3319	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XC_3320	COG0201	protein transport
XC_3323	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XC_3327	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XC_3329	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XC_3330	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
XC_3335	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XC_3352	COG0250	Participates in transcription elongation, termination and antitermination
XC_3353	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XC_3354	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XC_3355	COG0012	GTP binding
XC_3358	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XC_3365	COG0521	Mo-molybdopterin cofactor biosynthetic process
XC_3369	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XC_3375	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XC_3376	COG1404	Belongs to the peptidase S8 family
XC_3377	COG1404	Belongs to the peptidase S8 family
XC_3378	COG1404	Belongs to the peptidase S8 family
XC_3379	COG1404	Belongs to the peptidase S8 family
XC_3380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XC_3390	COG0778	Nitroreductase
XC_3391	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XC_3391	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XC_3395	COG2890	protein-(glutamine-N5) methyltransferase activity
XC_3397	COG3634	alkyl hydroperoxide reductase activity
XC_3398	COG0583	DNA-binding transcription factor activity
XC_3399	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XC_3404	COG2197	response regulator
XC_3405	COG5002	protein histidine kinase activity
XC_3405	COG0784	Response regulator, receiver
XC_3405	COG2205	protein histidine kinase activity
XC_3406	COG0745	RESPONSE REGULATOR receiver
XC_3406	COG3706	GGDEF domain
XC_3411	COG0697	spore germination
XC_3416	COG3386	PFAM SMP-30 Gluconolaconase
XC_3420	COG1024	Enoyl-CoA hydratase
XC_3424	COG0318	PFAM AMP-dependent synthetase and ligase
XC_3425	COG0583	DNA-binding transcription factor activity
XC_3426	COG3384	dioxygenase
XC_3432	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XC_3433	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XC_3435	COG2096	Adenosyltransferase
XC_3436	COG0123	including yeast histone deacetylase and acetoin utilization protein
XC_3442	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XC_3449	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XC_3451	COG0642	Histidine kinase
XC_3454	COG4181	ATPase activity
XC_3456	COG2175	clavaminate synthase activity
XC_3458	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XC_3459	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XC_3463	COG4771	TonB-dependent receptor
XC_3466	COG0667	Aldo Keto reductase
XC_3467	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XC_3469	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XC_3487	COG0366	Alpha amylase catalytic
XC_3493	COG1028	Short-chain dehydrogenase reductase Sdr
XC_3493	COG0604	alcohol dehydrogenase
XC_3493	COG3321	synthase
XC_3496	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XC_3499	COG0494	nUDIX hydrolase
XC_3502	COG0739	heme binding
XC_3507	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XC_3508	COG1181	Belongs to the D-alanine--D-alanine ligase family
XC_3513	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XC_3516	COG3116	cell division
XC_3518	COG2001	Belongs to the MraZ family
XC_3525	COG1988	membrane-bound metal-dependent
XC_3526	COG0277	FAD linked oxidase domain protein
XC_3528	COG0745	RESPONSE REGULATOR receiver
XC_3529	COG2205	protein histidine kinase activity
XC_3531	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XC_3532	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XC_3535	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XC_3541	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XC_3541	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XC_3546	COG0488	(ABC) transporter
XC_3547	COG0242	peptide deformylase activity
XC_3548	COG1393	Belongs to the ArsC family
XC_3551	COG0457	Tetratricopeptide repeat
XC_3561	COG2188	Transcriptional regulator
XC_3563	COG1450	Type ii and iii secretion system protein
XC_3566	COG3166	PFAM Fimbrial assembly family protein
XC_3567	COG3156	type II secretion system protein K
XC_3568	COG4795	General secretion pathway protein
XC_3569	COG2165	general secretion pathway protein
XC_3570	COG4970	Tfp pilus assembly protein FimT
XC_3571	COG2165	general secretion pathway protein
XC_3572	COG1459	type II secretion system
XC_3573	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XC_3575	COG1404	Belongs to the peptidase S8 family
XC_3578	COG0047	phosphoribosylformylglycinamidine synthase activity
XC_3578	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XC_3579	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XC_3580	COG4974	Belongs to the 'phage' integrase family
XC_3583	COG0795	lipopolysaccharide-transporting ATPase activity
XC_3594	COG1183	phosphatidylcholine synthase activity
XC_3599	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XC_3600	COG1127	ABC transporter
XC_3601	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XC_3601	COG3218	ABC-type transport auxiliary lipoprotein component
XC_3605	COG3754	Rhamnan synthesis protein F
XC_3606	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XC_3607	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XC_3608	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XC_3609	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XC_3609	COG0662	Cupin 2, conserved barrel domain protein
XC_3614	COG2086	electron transfer activity
XC_3616	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XC_3616	COG0662	Cupin 2, conserved barrel domain protein
XC_3617	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
XC_3618	COG0463	Glycosyl transferase, family 2
XC_3623	COG2963	transposase activity
XC_3624	COG2801	Transposase and inactivated derivatives
XC_3625	COG3039	Transposase
XC_3627	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
XC_3630	COG0438	transferase activity, transferring glycosyl groups
XC_3635	COG0626	cystathionine gamma-synthase activity
XC_3641	COG0625	glutathione transferase activity
XC_3643	COG0513	Belongs to the DEAD box helicase family
XC_3644	COG0720	synthase
XC_3647	COG1956	GAF domain-containing protein
XC_3653	COG0339	signal peptide processing
XC_3655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XC_3663	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XC_3665	COG1136	(ABC) transporter
XC_3667	COG0577	efflux transmembrane transporter activity
XC_3667	COG1136	(ABC) transporter
XC_3669	COG2204	response regulator
XC_3671	COG2963	transposase activity
XC_3672	COG2801	Transposase and inactivated derivatives
XC_3684	COG0356	it plays a direct role in the translocation of protons across the membrane
XC_3687	COG1228	amidohydrolase
XC_3689	COG0508	dehydrogenase complex catalyzes the overall conversion of
XC_3691	COG0508	dehydrogenase complex catalyzes the overall conversion of
XC_3700	COG2011	ABC-type metal ion transport system permease component
XC_3702	COG0697	spore germination
XC_3703	COG1666	GTP binding
XC_3708	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XC_3709	COG1187	pseudouridine synthase activity
XC_3710	COG2813	Specifically methylates the guanine in position
XC_3714	COG5002	protein histidine kinase activity
XC_3720	COG1522	sequence-specific DNA binding
XC_3730	COG0842	Transport permease protein
XC_3731	COG1131	(ABC) transporter
XC_3732	COG0025	NhaP-type Na H and K H
XC_3733	COG3795	YCII-related domain
XC_3734	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XC_3735	COG1573	uracil-dna glycosylase
XC_3737	COG3384	dioxygenase
XC_3738	COG0583	DNA-binding transcription factor activity
XC_3740	COG0667	Aldo Keto reductase
XC_3742	COG3590	peptidase
XC_3745	COG0531	amino acid
XC_3748	COG2972	Histidine kinase
XC_3751	COG1335	isochorismatase
XC_3752	COG3685	Protein conserved in bacteria
XC_3753	COG3685	Protein conserved in bacteria
XC_3754	COG3546	catalase activity
XC_3760	COG2204	response regulator
XC_3762	COG1271	oxidase subunit
XC_3763	COG1294	oxidase, subunit
XC_3766	COG1028	Short-chain dehydrogenase reductase Sdr
XC_3767	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XC_3771	COG1132	(ABC) transporter
XC_3774	COG1063	alcohol dehydrogenase
XC_3780	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XC_3791	COG0251	oxidation-reduction process
XC_3795	COG0667	Aldo Keto reductase
XC_3796	COG0583	DNA-binding transcription factor activity
XC_3800	COG3706	GGDEF domain
XC_3800	COG4251	negative regulation of phosphorylation
XC_3800	COG5001	Diguanylate cyclase
XC_3800	COG2203	Gaf domain
XC_3803	COG2963	transposase activity
XC_3806	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XC_3808	COG1560	Kdo2-lipid A biosynthetic process
XC_3810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XC_3817	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XC_3817	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XC_3819	COG0242	peptide deformylase activity
XC_3820	COG1652	LysM domain
XC_3821	COG0758	DNA mediated transformation
XC_3825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XC_3825	COG1754	DNA topoisomerase type I activity
XC_3829	COG4251	negative regulation of phosphorylation
XC_3829	COG3706	GGDEF domain
XC_3829	COG2203	Gaf domain
XC_3829	COG5001	Diguanylate cyclase
XC_3830	COG1028	Short-chain dehydrogenase reductase Sdr
XC_3832	COG0616	signal peptide processing
XC_3833	COG0534	Mate efflux family protein
XC_3836	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XC_3837	COG0625	glutathione transferase activity
XC_3838	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XC_3841	COG1252	NADH dehydrogenase
XC_3842	COG2860	membrane
XC_3843	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XC_3845	COG3437	response regulator, receiver
XC_3846	COG2177	Part of the ABC transporter FtsEX involved in
XC_3847	COG2884	Cell division ATP-binding protein ftsE
XC_3849	COG3118	belongs to the thioredoxin family
XC_3850	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XC_3859	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XC_3864	COG4941	Belongs to the sigma-70 factor family
XC_3865	COG5383	Protein conserved in bacteria
XC_3873	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
XC_3874	COG3409	Peptidoglycan-binding domain 1 protein
XC_3877	COG3023	N-Acetylmuramoyl-L-alanine amidase
XC_3879	COG4948	Mandelate Racemase Muconate Lactonizing
XC_3881	COG0531	amino acid
XC_3884	COG4682	membrane
XC_3885	COG2133	pyrroloquinoline quinone binding
XC_3887	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XC_3889	COG0828	Belongs to the bacterial ribosomal protein bS21 family
XC_3890	COG1610	YqeY-like protein
XC_3891	COG1295	ribonuclease BN
XC_3892	COG0358	DNA primase activity
XC_3902	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XC_3905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XC_3915	COG2963	transposase activity
XC_3917	COG2801	Transposase and inactivated derivatives
XC_3918	COG2963	transposase activity
XC_3921	COG2963	transposase activity
XC_3923	COG3039	Transposase
XC_3926	COG0739	heme binding
XC_3930	COG0708	Exodeoxyribonuclease III
XC_3933	COG1192	Involved in chromosome partitioning
XC_3934	COG1475	DNA binding
XC_3938	COG0463	Glycosyl transferase, family 2
XC_3943	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XC_3944	COG2003	Belongs to the UPF0758 family
XC_3948	COG4221	oxidoreductase activity
XC_3949	COG2755	lipolytic protein G-D-S-L family
XC_3949	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XC_3952	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XC_3953	COG1166	arginine decarboxylase activity
XC_3958	COG2960	long-chain fatty acid transporting porin activity
XC_3959	COG0606	chelatase, subunit chli
XC_3962	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XC_3970	COG1690	Belongs to the RtcB family
XC_3978	COG1090	epimerase
XC_3979	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XC_3981	COG0745	RESPONSE REGULATOR receiver
XC_3982	COG0642	Histidine kinase
XC_3986	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XC_3991	COG1011	Hydrolase
XC_3992	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XC_3997	COG2197	response regulator
XC_3998	COG4585	Histidine kinase
XC_4000	COG1136	(ABC) transporter
XC_4005	COG0697	spore germination
XC_4011	COG0180	Tryptophanyl-tRNA synthetase
XC_4012	COG3237	CsbD-like
XC_4026	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XC_4026	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XC_4027	COG3228	Belongs to the MtfA family
XC_4030	COG2205	protein histidine kinase activity
XC_4031	COG0745	RESPONSE REGULATOR receiver
XC_4033	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XC_4038	COG1199	ATP-dependent helicase activity
XC_4052	COG0625	glutathione transferase activity
XC_4059	COG4555	ABC transporter
XC_4061	COG1476	TRANSCRIPTIONal
XC_4064	COG1230	cation diffusion facilitator family transporter
XC_4066	COG1131	(ABC) transporter
XC_4067	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XC_4068	COG0842	Transport permease protein
XC_4070	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XC_4072	COG1607	acyl-coa hydrolase
XC_4075	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XC_4076	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XC_4078	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XC_4078	COG1042	CoA-binding domain protein
XC_4078	COG0045	succinate-CoA ligase (ADP-forming) activity
XC_4079	COG2239	Acts as a magnesium transporter
XC_4082	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XC_4083	COG3387	PFAM Glycoside hydrolase 15-related
XC_4087	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XC_4089	COG0463	Glycosyl transferase, family 2
XC_4092	COG1028	Short-chain dehydrogenase reductase Sdr
XC_4098	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XC_4101	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XC_4115	COG0210	DNA helicase
XC_4117	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XC_4119	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XC_4121	COG2159	amidohydrolase
XC_4122	COG0267	Belongs to the bacterial ribosomal protein bL33 family
XC_4123	COG0227	Belongs to the bacterial ribosomal protein bL28 family
XC_4132	COG2091	lysine biosynthetic process via aminoadipic acid
XC_4144	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XC_4146	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XC_4147	COG3162	membrane
XC_4154	COG3507	Belongs to the glycosyl hydrolase 43 family
XC_4157	COG1028	Short-chain dehydrogenase reductase Sdr
XC_4158	COG0179	Fumarylacetoacetate (FAA) hydrolase
XC_4159	COG4948	Mandelate Racemase Muconate Lactonizing
XC_4160	COG3254	rhamnose metabolic process
XC_4161	COG0738	Major facilitator superfamily
XC_4162	COG1414	Transcriptional regulator
XC_4167	COG2205	protein histidine kinase activity
XC_4167	COG0784	Response regulator, receiver
XC_4168	COG3459	Glycosyltransferase 36 associated
XC_4169	COG2211	Major facilitator Superfamily
XC_4170	COG3265	gluconokinase activity
XC_4171	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XC_4175	COG2911	Protein conserved in bacteria
XC_4176	COG0729	surface antigen
XC_4180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XC_4180	COG0519	Catalyzes the synthesis of GMP from XMP
XC_4182	COG0805	protein transport
XC_4186	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XC_4193	COG3661	Belongs to the glycosyl hydrolase 67 family
XC_4195	COG4948	Mandelate Racemase Muconate Lactonizing
XC_4197	COG1472	Belongs to the glycosyl hydrolase 3 family
XC_4198	COG0246	Mannitol dehydrogenase
XC_4205	COG3386	PFAM SMP-30 Gluconolaconase
XC_4208	COG3250	beta-galactosidase activity
XC_4210	COG3693	PFAM glycoside hydrolase, family 10
XC_4213	COG2211	Major facilitator Superfamily
XC_4220	COG2937	Belongs to the GPAT DAPAT family
XC_4227	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
XC_4228	COG3132	Protein of unknown function, DUF480
XC_4231	COG0210	DNA helicase
XC_4232	COG2963	transposase activity
XC_4233	COG2801	Transposase and inactivated derivatives
XC_4234	COG3002	Belongs to the UPF0753 family
XC_4240	COG3135	benzoate transporter
XC_4244	COG0676	glucose-6-phosphate 1-epimerase activity
XC_4246	COG3012	SEC-C Motif Domain Protein
XC_4248	COG0730	response to heat
XC_4253	COG0302	gtp cyclohydrolase
XC_4256	COG1566	PFAM secretion protein HlyD family protein
XC_4258	COG1289	transmembrane transporter activity
XC_4259	COG0477	Major facilitator Superfamily
XC_4261	COG0583	DNA-binding transcription factor activity
XC_4262	COG4221	oxidoreductase activity
XC_4263	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XC_4271	COG3039	Transposase
XC_4278	COG0564	pseudouridine synthase activity
XC_4281	COG1192	Involved in chromosome partitioning
XC_4288	COG1074	ATP-dependent DNA helicase activity
XC_4289	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XC_4296	COG1127	ABC transporter
XC_4297	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XC_4298	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XC_4301	COG2853	Lipoprotein
XC_4302	COG0386	Belongs to the glutathione peroxidase family
XC_4304	COG1322	Protein conserved in bacteria
XC_4305	COG0604	alcohol dehydrogenase
XC_4306	COG0583	DNA-binding transcription factor activity
XC_4309	COG0531	amino acid
XC_4311	COG4206	TonB-dependent receptor
XC_4313	COG2199	diguanylate cyclase activity
XC_4313	COG2203	Gaf domain
XC_4314	COG3835	regulator
XC_4315	COG1929	Belongs to the glycerate kinase type-1 family
XC_4316	COG2271	Major facilitator Superfamily
XC_4320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XC_4321	COG0861	Integral membrane protein TerC family
XC_4324	COG0584	glycerophosphoryl diester phosphodiesterase
XC_4326	COG0671	phosphoesterase, PA-phosphatase related
XC_4329	COG0726	polysaccharide deacetylase
XC_4332	COG0230	Belongs to the bacterial ribosomal protein bL34 family