locus-tag	class	description
JH290_00025	COG0726	polysaccharide deacetylase
JH290_00040	COG0671	phosphoesterase, PA-phosphatase related
JH290_00050	COG0584	glycerophosphoryl diester phosphodiesterase
JH290_00060	COG0861	Integral membrane protein TerC family
JH290_00065	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JH290_00090	COG2271	Major facilitator Superfamily
JH290_00095	COG1929	Belongs to the glycerate kinase type-1 family
JH290_00100	COG3835	regulator
JH290_00105	COG3706	GGDEF domain
JH290_00115	COG4206	TonB-dependent receptor
JH290_00125	COG0531	amino acid
JH290_00140	COG0583	DNA-binding transcription factor activity
JH290_00145	COG0604	alcohol dehydrogenase
JH290_00155	COG1322	Protein conserved in bacteria
JH290_00165	COG0386	Belongs to the glutathione peroxidase family
JH290_00175	COG2853	Lipoprotein
JH290_00190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JH290_00195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JH290_00200	COG1127	ABC transporter
JH290_00205	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JH290_00210	COG1074	ATP-dependent DNA helicase activity
JH290_00315	COG1487	ribonuclease activity
JH290_00335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JH290_00355	COG0477	Major facilitator Superfamily
JH290_00360	COG1289	transmembrane transporter activity
JH290_00370	COG1566	PFAM secretion protein HlyD family protein
JH290_00385	COG0302	gtp cyclohydrolase
JH290_00410	COG0730	response to heat
JH290_00430	COG0676	glucose-6-phosphate 1-epimerase activity
JH290_00455	COG3135	benzoate transporter
JH290_00520	COG0210	DNA helicase
JH290_00540	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
JH290_00575	COG2937	Belongs to the GPAT DAPAT family
JH290_00580	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_00580	COG3321	synthase
JH290_00580	COG0604	alcohol dehydrogenase
JH290_00635	COG2211	Major facilitator Superfamily
JH290_00650	COG3693	PFAM glycoside hydrolase, family 10
JH290_00660	COG3250	beta-galactosidase activity
JH290_00685	COG3386	PFAM SMP-30 Gluconolaconase
JH290_00725	COG0246	Mannitol dehydrogenase
JH290_00730	COG1472	Belongs to the glycosyl hydrolase 3 family
JH290_00740	COG4948	Mandelate Racemase Muconate Lactonizing
JH290_00750	COG3661	Belongs to the glycosyl hydrolase 67 family
JH290_00785	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JH290_00805	COG0805	protein transport
JH290_00815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JH290_00815	COG0519	Catalyzes the synthesis of GMP from XMP
JH290_00820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JH290_00835	COG0729	surface antigen
JH290_00840	COG2911	Protein conserved in bacteria
JH290_00860	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JH290_00865	COG3265	gluconokinase activity
JH290_00870	COG2211	Major facilitator Superfamily
JH290_00875	COG3459	Glycosyltransferase 36 associated
JH290_00880	COG2205	protein histidine kinase activity
JH290_00880	COG0784	Response regulator, receiver
JH290_00900	COG1414	Transcriptional regulator
JH290_00905	COG0738	Major facilitator superfamily
JH290_00910	COG3254	rhamnose metabolic process
JH290_00915	COG4948	Mandelate Racemase Muconate Lactonizing
JH290_00925	COG0179	Fumarylacetoacetate (FAA) hydrolase
JH290_00930	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_00945	COG3507	Belongs to the glycosyl hydrolase 43 family
JH290_00980	COG3162	membrane
JH290_00985	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JH290_00995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JH290_01065	COG2091	lysine biosynthetic process via aminoadipic acid
JH290_01125	COG2159	amidohydrolase
JH290_01135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JH290_01140	COG0583	DNA-binding transcription factor activity
JH290_01145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JH290_01155	COG0210	DNA helicase
JH290_01240	COG1121	(ABC) transporter
JH290_01295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JH290_01310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JH290_01340	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_01360	COG0463	Glycosyl transferase, family 2
JH290_01370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JH290_01390	COG3387	PFAM Glycoside hydrolase 15-related
JH290_01395	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JH290_01410	COG2239	Acts as a magnesium transporter
JH290_01420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JH290_01420	COG1042	CoA-binding domain protein
JH290_01420	COG0045	succinate-CoA ligase (ADP-forming) activity
JH290_01430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JH290_01435	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JH290_01460	COG1607	acyl-coa hydrolase
JH290_01475	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JH290_01485	COG0842	Transport permease protein
JH290_01490	COG1131	(ABC) transporter
JH290_01495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JH290_01520	COG1476	TRANSCRIPTIONal
JH290_01530	COG4555	ABC transporter
JH290_01570	COG0625	glutathione transferase activity
JH290_01630	COG1199	ATP-dependent helicase activity
JH290_01665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JH290_01695	COG3228	Belongs to the MtfA family
JH290_01705	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
JH290_01705	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
JH290_01780	COG3237	CsbD-like
JH290_01785	COG0180	Tryptophanyl-tRNA synthetase
JH290_01805	COG0697	spore germination
JH290_01830	COG1136	(ABC) transporter
JH290_01845	COG4585	Histidine kinase
JH290_01850	COG2197	response regulator
JH290_01880	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JH290_01885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JH290_01910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JH290_01930	COG0642	Histidine kinase
JH290_01945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JH290_01950	COG1090	epimerase
JH290_01995	COG1690	Belongs to the RtcB family
JH290_02030	COG4943	cyclic-guanylate-specific phosphodiesterase activity
JH290_02045	COG0606	chelatase, subunit chli
JH290_02050	COG2960	long-chain fatty acid transporting porin activity
JH290_02075	COG1166	arginine decarboxylase activity
JH290_02085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JH290_02095	COG2755	lipolytic protein G-D-S-L family
JH290_02095	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JH290_02100	COG4221	oxidoreductase activity
JH290_02125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JH290_02150	COG0463	Glycosyl transferase, family 2
JH290_02170	COG1475	DNA binding
JH290_02175	COG1192	Involved in chromosome partitioning
JH290_02190	COG0708	Exodeoxyribonuclease III
JH290_02195	COG2211	Major facilitator Superfamily
JH290_02210	COG0739	heme binding
JH290_02255	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JH290_02270	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
JH290_02320	COG0358	DNA primase activity
JH290_02325	COG1295	ribonuclease BN
JH290_02330	COG1610	YqeY-like protein
JH290_02345	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JH290_02355	COG2133	pyrroloquinoline quinone binding
JH290_02360	COG4682	membrane
JH290_02375	COG0531	amino acid
JH290_02385	COG4948	Mandelate Racemase Muconate Lactonizing
JH290_02395	COG3023	N-Acetylmuramoyl-L-alanine amidase
JH290_02410	COG3501	Rhs element vgr protein
JH290_02410	COG3409	Peptidoglycan-binding domain 1 protein
JH290_02415	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
JH290_02455	COG5383	Protein conserved in bacteria
JH290_02460	COG4941	Belongs to the sigma-70 factor family
JH290_02490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JH290_02495	COG1473	amidohydrolase
JH290_02540	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JH290_02545	COG3118	belongs to the thioredoxin family
JH290_02555	COG2884	Cell division ATP-binding protein ftsE
JH290_02560	COG2177	Part of the ABC transporter FtsEX involved in
JH290_02565	COG2201	protein-glutamate methylesterase activity
JH290_02575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JH290_02580	COG2860	membrane
JH290_02585	COG1252	NADH dehydrogenase
JH290_02600	COG0625	glutathione transferase activity
JH290_02605	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JH290_02620	COG0534	Mate efflux family protein
JH290_02625	COG0616	signal peptide processing
JH290_02635	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_02640	COG4251	negative regulation of phosphorylation
JH290_02640	COG5001	Diguanylate cyclase
JH290_02640	COG2203	Gaf domain
JH290_02640	COG3706	GGDEF domain
JH290_02660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JH290_02660	COG1754	DNA topoisomerase type I activity
JH290_02680	COG0758	DNA mediated transformation
JH290_02685	COG1652	LysM domain
JH290_02690	COG0242	peptide deformylase activity
JH290_02700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JH290_02700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JH290_02735	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JH290_02745	COG1560	Kdo2-lipid A biosynthetic process
JH290_02755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JH290_02775	COG3039	Transposase
JH290_02815	COG2963	transposase activity
JH290_02830	COG1192	Involved in chromosome partitioning
JH290_02900	COG3706	GGDEF domain
JH290_02900	COG2203	Gaf domain
JH290_02900	COG4251	negative regulation of phosphorylation
JH290_02900	COG5001	Diguanylate cyclase
JH290_02920	COG0583	DNA-binding transcription factor activity
JH290_02925	COG0667	Aldo Keto reductase
JH290_02945	COG0251	oxidation-reduction process
JH290_03005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JH290_03045	COG1063	alcohol dehydrogenase
JH290_03060	COG1132	(ABC) transporter
JH290_03080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JH290_03085	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_03100	COG1294	oxidase, subunit
JH290_03105	COG1271	oxidase subunit
JH290_03115	COG2204	response regulator
JH290_03145	COG3546	catalase activity
JH290_03150	COG3685	Protein conserved in bacteria
JH290_03155	COG3685	Protein conserved in bacteria
JH290_03160	COG1335	isochorismatase
JH290_03180	COG2972	Histidine kinase
JH290_03195	COG0531	amino acid
JH290_03210	COG3590	peptidase
JH290_03220	COG0667	Aldo Keto reductase
JH290_03230	COG0583	DNA-binding transcription factor activity
JH290_03235	COG3384	dioxygenase
JH290_03245	COG1573	uracil-dna glycosylase
JH290_03250	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
JH290_03255	COG3795	YCII-related domain
JH290_03260	COG0025	NhaP-type Na H and K H
JH290_03265	COG1131	(ABC) transporter
JH290_03270	COG0842	Transport permease protein
JH290_03350	COG5002	protein histidine kinase activity
JH290_03370	COG2813	Specifically methylates the guanine in position
JH290_03375	COG1187	pseudouridine synthase activity
JH290_03380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JH290_03410	COG0697	spore germination
JH290_03420	COG2011	ABC-type metal ion transport system permease component
JH290_03450	COG0508	dehydrogenase complex catalyzes the overall conversion of
JH290_03460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JH290_03465	COG1228	amidohydrolase
JH290_03480	COG0356	it plays a direct role in the translocation of protons across the membrane
JH290_03545	COG4191	Histidine kinase
JH290_03560	COG1136	(ABC) transporter
JH290_03560	COG0577	efflux transmembrane transporter activity
JH290_03570	COG1136	(ABC) transporter
JH290_03580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JH290_03630	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JH290_03635	COG0339	signal peptide processing
JH290_03665	COG1956	GAF domain-containing protein
JH290_03680	COG0720	synthase
JH290_03685	COG0513	Belongs to the DEAD box helicase family
JH290_03695	COG0625	glutathione transferase activity
JH290_03725	COG0626	cystathionine gamma-synthase activity
JH290_03750	COG0438	transferase activity, transferring glycosyl groups
JH290_03765	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
JH290_03790	COG0463	Glycosyl transferase, family 2
JH290_03795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JH290_03810	COG2086	electron transfer activity
JH290_03835	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
JH290_03835	COG0662	Cupin 2, conserved barrel domain protein
JH290_03840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JH290_03880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JH290_03880	COG3218	ABC-type transport auxiliary lipoprotein component
JH290_03885	COG1127	ABC transporter
JH290_03890	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JH290_03915	COG1183	phosphatidylcholine synthase activity
JH290_03970	COG0795	lipopolysaccharide-transporting ATPase activity
JH290_03985	COG4974	Belongs to the 'phage' integrase family
JH290_03990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JH290_03995	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JH290_03995	COG0047	phosphoribosylformylglycinamidine synthase activity
JH290_04010	COG1404	Belongs to the peptidase S8 family
JH290_04015	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JH290_04020	COG1459	type II secretion system
JH290_04025	COG2165	general secretion pathway protein
JH290_04030	COG4970	Tfp pilus assembly protein FimT
JH290_04035	COG2165	general secretion pathway protein
JH290_04040	COG4795	General secretion pathway protein
JH290_04045	COG3156	type II secretion system protein K
JH290_04050	COG3166	PFAM Fimbrial assembly family protein
JH290_04065	COG1450	Type ii and iii secretion system protein
JH290_04075	COG2188	Transcriptional regulator
JH290_04135	COG0457	Tetratricopeptide repeat
JH290_04150	COG1393	Belongs to the ArsC family
JH290_04155	COG0242	peptide deformylase activity
JH290_04160	COG0488	(ABC) transporter
JH290_04185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JH290_04185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JH290_04215	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JH290_04230	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
JH290_04235	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
JH290_04245	COG2205	protein histidine kinase activity
JH290_04250	COG0745	RESPONSE REGULATOR receiver
JH290_04255	COG0277	FAD linked oxidase domain protein
JH290_04260	COG1988	membrane-bound metal-dependent
JH290_04310	COG0275	rRNA processing
JH290_04315	COG3116	cell division
JH290_04330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JH290_04355	COG1181	Belongs to the D-alanine--D-alanine ligase family
JH290_04360	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JH290_04385	COG0739	heme binding
JH290_04400	COG0494	nUDIX hydrolase
JH290_04415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JH290_04430	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_04430	COG3321	synthase
JH290_04430	COG0604	alcohol dehydrogenase
JH290_04470	COG0366	Alpha amylase catalytic
JH290_04560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JH290_04570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JH290_04575	COG0667	Aldo Keto reductase
JH290_04585	COG4771	TonB-dependent receptor
JH290_04610	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
JH290_04620	COG2175	clavaminate synthase activity
JH290_04630	COG4181	ATPase activity
JH290_04645	COG0642	Histidine kinase
JH290_04655	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JH290_04690	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JH290_04720	COG0123	including yeast histone deacetylase and acetoin utilization protein
JH290_04725	COG2096	Adenosyltransferase
JH290_04735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JH290_04740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JH290_04770	COG3384	dioxygenase
JH290_04775	COG0583	DNA-binding transcription factor activity
JH290_04780	COG0318	PFAM AMP-dependent synthetase and ligase
JH290_04790	COG1024	Enoyl-CoA hydratase
JH290_04810	COG3386	PFAM SMP-30 Gluconolaconase
JH290_04840	COG0697	spore germination
JH290_04900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JH290_04905	COG0583	DNA-binding transcription factor activity
JH290_04910	COG3634	alkyl hydroperoxide reductase activity
JH290_04920	COG2890	protein-(glutamine-N5) methyltransferase activity
JH290_04940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JH290_04940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JH290_04945	COG0778	Nitroreductase
JH290_05010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JH290_05015	COG1404	Belongs to the peptidase S8 family
JH290_05020	COG1404	Belongs to the peptidase S8 family
JH290_05025	COG1404	Belongs to the peptidase S8 family
JH290_05030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JH290_05060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JH290_05080	COG0521	Mo-molybdopterin cofactor biosynthetic process
JH290_05120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JH290_05130	COG0193	aminoacyl-tRNA hydrolase activity
JH290_05135	COG0012	GTP binding
JH290_05170	COG0250	Participates in transcription elongation, termination and antitermination
JH290_05245	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JH290_05330	COG0201	protein transport
JH290_05370	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
JH290_05385	COG0154	amidase activity
JH290_05395	COG1217	gtp-binding protein TYPA
JH290_05400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JH290_05410	COG0625	glutathione transferase activity
JH290_05425	COG0446	pyridine nucleotide-disulphide oxidoreductase
JH290_05425	COG1902	pentaerythritol trinitrate reductase activity
JH290_05430	COG0604	alcohol dehydrogenase
JH290_05460	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
JH290_05465	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
JH290_05470	COG4208	sulfate ABC transporter
JH290_05475	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JH290_05500	COG0406	alpha-ribazole phosphatase activity
JH290_05515	COG0285	dihydrofolate synthase activity
JH290_05535	COG2833	Protein of unknown function (DUF455)
JH290_05545	COG3291	Pkd domain containing protein
JH290_05555	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JH290_05560	COG0671	phosphoesterase, PA-phosphatase related
JH290_05565	COG0438	transferase activity, transferring glycosyl groups
JH290_05575	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JH290_05585	COG0745	RESPONSE REGULATOR receiver
JH290_05590	COG4783	chaperone-mediated protein folding
JH290_05605	COG0473	3-isopropylmalate dehydrogenase activity
JH290_05680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JH290_05705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JH290_05710	COG0631	protein serine/threonine phosphatase activity
JH290_05725	COG0859	PFAM glycosyl transferase family 9
JH290_05735	COG1234	tRNA 3'-trailer cleavage
JH290_05755	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
JH290_05760	COG0314	molybdopterin synthase activity
JH290_05790	COG0537	adenosine 5'-monophosphoramidase activity
JH290_05810	COG0714	Associated with various cellular activities
JH290_05845	COG1399	metal-binding, possibly nucleic acid-binding protein
JH290_05855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JH290_05860	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JH290_05865	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_05880	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JH290_05885	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JH290_05915	COG3829	transcription factor binding
JH290_05935	COG3609	addiction module antidote protein, CC2985 family
JH290_05960	COG2373	Large extracellular alpha-helical protein
JH290_05985	COG4953	penicillin-binding protein 1C
JH290_05995	COG0678	peroxiredoxin activity
JH290_06015	COG0330	HflC and HflK could
JH290_06020	COG0330	HflC and HflK could
JH290_06035	COG0308	aminopeptidase N
JH290_06080	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JH290_06095	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JH290_06130	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JH290_06145	COG3387	PFAM Glycoside hydrolase 15-related
JH290_06150	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_06165	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_06210	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JH290_06215	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
JH290_06220	COG2080	2 iron, 2 sulfur cluster binding
JH290_06250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JH290_06275	COG1297	OPT oligopeptide transporter protein
JH290_06285	COG0823	Involved in the tonB-independent uptake of proteins
JH290_06285	COG1506	peptidase
JH290_06305	COG2207	Transcriptional regulator
JH290_06305	COG1917	Cupin 2, conserved barrel domain protein
JH290_06320	COG0753	catalase activity
JH290_06325	COG0656	L-ascorbic acid biosynthetic process
JH290_06345	COG2814	Major facilitator Superfamily
JH290_06365	COG2194	sulfuric ester hydrolase activity
JH290_06380	COG0745	RESPONSE REGULATOR receiver
JH290_06385	COG5002	protein histidine kinase activity
JH290_06400	COG2894	cell division
JH290_06415	COG4585	Histidine kinase
JH290_06420	COG2197	response regulator
JH290_06450	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
JH290_06455	COG0277	FAD linked oxidase domain protein
JH290_06515	COG1595	DNA-templated transcription, initiation
JH290_06525	COG1946	Acyl-CoA thioesterase
JH290_06530	COG1024	Enoyl-CoA hydratase
JH290_06535	COG0824	Thioesterase
JH290_06540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JH290_06570	COG0196	riboflavin kinase activity
JH290_06600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JH290_06605	COG1845	cytochrome c oxidase, subunit III
JH290_06610	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JH290_06625	COG3152	Membrane
JH290_06635	COG2207	Transcriptional regulator
JH290_06640	COG0326	Molecular chaperone. Has ATPase activity
JH290_06650	COG1902	pentaerythritol trinitrate reductase activity
JH290_06655	COG1366	Belongs to the anti-sigma-factor antagonist family
JH290_06660	COG1366	Belongs to the anti-sigma-factor antagonist family
JH290_06665	COG2172	sigma factor antagonist activity
JH290_06675	COG2205	protein histidine kinase activity
JH290_06695	COG4771	TonB-dependent receptor
JH290_06705	COG5507	3-demethylubiquinone-9 3-methyltransferase
JH290_06710	COG2205	protein histidine kinase activity
JH290_06720	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JH290_06725	COG3437	response regulator, receiver
JH290_06725	COG3850	Histidine kinase
JH290_06725	COG2205	protein histidine kinase activity
JH290_06725	COG4999	Histidine kinase
JH290_06730	COG0784	Response regulator, receiver
JH290_06730	COG4191	Histidine kinase
JH290_06760	COG3534	alpha-L-arabinofuranosidase
JH290_06770	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JH290_06775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JH290_06790	COG2070	2-Nitropropane dioxygenase
JH290_06820	COG0534	Mate efflux family protein
JH290_06840	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JH290_06860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JH290_06865	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_06870	COG0436	Aminotransferase
JH290_06875	COG1309	transcriptional regulator
JH290_06905	COG5297	Belongs to the glycosyl hydrolase family 6
JH290_06960	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JH290_07035	COG2963	transposase activity
JH290_07065	COG3039	Transposase
JH290_07085	COG3039	Transposase
JH290_07090	COG3250	beta-galactosidase activity
JH290_07095	COG3867	Arabinogalactan endo-beta-1,4-galactanase
JH290_07105	COG1396	sequence-specific DNA binding
JH290_07105	COG3800	Transcriptional regulator
JH290_07115	COG1960	acyl-CoA dehydrogenase activity
JH290_07120	COG1024	Enoyl-CoA hydratase
JH290_07155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JH290_07205	COG2954	triphosphatase activity
JH290_07210	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JH290_07215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JH290_07215	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JH290_07220	COG3046	protein related to deoxyribodipyrimidine photolyase
JH290_07230	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
JH290_07235	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JH290_07240	COG1278	Cold shock
JH290_07245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JH290_07255	COG1201	RNA secondary structure unwinding
JH290_07260	COG1793	dna ligase
JH290_07270	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
JH290_07270	COG1793	dna ligase
JH290_07300	COG0183	Belongs to the thiolase family
JH290_07315	COG1451	nucleotide metabolic process
JH290_07320	COG5487	UPF0391 membrane protein
JH290_07330	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JH290_07375	COG1047	Peptidyl-prolyl cis-trans
JH290_07385	COG2824	Alkylphosphonate utilization operon protein PhnA
JH290_07405	COG1902	pentaerythritol trinitrate reductase activity
JH290_07410	COG2814	Major facilitator Superfamily
JH290_07445	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
JH290_07445	COG0392	lysyltransferase activity
JH290_07455	COG0251	oxidation-reduction process
JH290_07460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JH290_07475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JH290_07500	COG1595	DNA-templated transcription, initiation
JH290_07515	COG2878	Part of a membrane complex involved in electron transport
JH290_07535	COG0346	lactoylglutathione lyase activity
JH290_07540	COG0833	amino acid
JH290_07545	COG2040	homocysteine
JH290_07555	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JH290_07580	COG1695	Transcriptional regulator
JH290_07600	COG1981	membrane
JH290_07655	COG0750	zinc metalloprotease
JH290_07665	COG0575	Belongs to the CDS family
JH290_07670	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JH290_07680	COG0528	UMP kinase activity
JH290_07750	COG1393	Belongs to the ArsC family
JH290_07765	COG0367	asparagine synthase
JH290_07775	COG4774	siderophore transport
JH290_07815	COG1566	PFAM secretion protein HlyD family protein
JH290_07820	COG2814	Major facilitator Superfamily
JH290_07885	COG3104	oligopeptide transport
JH290_07920	COG0339	signal peptide processing
JH290_07925	COG0386	Belongs to the glutathione peroxidase family
JH290_07985	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JH290_07990	COG0084	hydrolase, TatD family'
JH290_08005	COG1960	acyl-CoA dehydrogenase activity
JH290_08020	COG0367	asparagine synthase
JH290_08030	COG0305	Participates in initiation and elongation during chromosome replication
JH290_08035	COG0415	Belongs to the DNA photolyase family
JH290_08045	COG0583	DNA-binding transcription factor activity
JH290_08055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JH290_08065	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_08085	COG3706	GGDEF domain
JH290_08105	COG1404	Belongs to the peptidase S8 family
JH290_08125	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JH290_08135	COG0497	DNA recombination
JH290_08140	COG1420	regulation of RNA biosynthetic process
JH290_08145	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JH290_08160	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
JH290_08185	COG2274	protein secretion by the type I secretion system
JH290_08190	COG0583	DNA-binding transcription factor activity
JH290_08195	COG1132	(ABC) transporter
JH290_08230	COG2850	peptidyl-arginine hydroxylation
JH290_08250	COG1253	flavin adenine dinucleotide binding
JH290_08280	COG1131	(ABC) transporter
JH290_08285	COG1725	Transcriptional regulator
JH290_08295	COG0386	Belongs to the glutathione peroxidase family
JH290_08325	COG1609	Transcriptional regulator
JH290_08335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JH290_08345	COG1410	methionine synthase
JH290_08345	COG0646	methionine synthase
JH290_08350	COG1410	methionine synthase
JH290_08350	COG0646	methionine synthase
JH290_08355	COG2226	methyltransferase
JH290_08360	COG1960	acyl-CoA dehydrogenase activity
JH290_08375	COG0557	exoribonuclease II activity
JH290_08385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JH290_08405	COG0704	Plays a role in the regulation of phosphate uptake
JH290_08415	COG0581	inorganic phosphate transmembrane transporter activity
JH290_08420	COG0573	inorganic phosphate transmembrane transporter activity
JH290_08425	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JH290_08450	COG0659	secondary active sulfate transmembrane transporter activity
JH290_08455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JH290_08465	COG1024	Enoyl-CoA hydratase
JH290_08475	COG0494	nUDIX hydrolase
JH290_08510	COG2264	protein methyltransferase activity
JH290_08515	COG0488	(ABC) transporter
JH290_08550	COG2925	Exonuclease
JH290_08575	COG0288	reversible hydration of carbon dioxide
JH290_08600	COG0017	Asparaginyl-tRNA synthetase
JH290_08605	COG0316	Belongs to the HesB IscA family
JH290_08640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JH290_08650	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
JH290_08670	COG4993	Dehydrogenase
JH290_08680	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JH290_08735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JH290_08745	COG0077	Prephenate dehydratase
JH290_08745	COG1605	Chorismate mutase
JH290_08755	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
JH290_08770	COG0583	DNA-binding transcription factor activity
JH290_08865	COG2003	Belongs to the UPF0758 family
JH290_08930	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JH290_08985	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
JH290_08990	COG4191	Histidine kinase
JH290_08990	COG0784	Response regulator, receiver
JH290_09005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JH290_09025	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JH290_09060	COG3038	cytochrome b561
JH290_09075	COG2244	polysaccharide biosynthetic process
JH290_09105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JH290_09110	COG0438	transferase activity, transferring glycosyl groups
JH290_09115	COG0438	transferase activity, transferring glycosyl groups
JH290_09135	COG1132	(ABC) transporter
JH290_09140	COG0477	Major facilitator Superfamily
JH290_09145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JH290_09160	COG1253	flavin adenine dinucleotide binding
JH290_09185	COG2134	cdp-diacylglycerol pyrophosphatase
JH290_09245	COG2840	Smr protein MutS2
JH290_09260	COG1238	metal cluster binding
JH290_09275	COG1534	Rna-binding protein
JH290_09285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JH290_09290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JH290_09305	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JH290_09310	COG1546	Belongs to the CinA family
JH290_09320	COG4771	TonB-dependent receptor
JH290_09330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JH290_09365	COG1741	Belongs to the pirin family
JH290_09370	COG0583	DNA-binding transcription factor activity
JH290_09395	COG0351	phosphomethylpyrimidine kinase
JH290_09395	COG0352	thiamine-phosphate diphosphorylase activity
JH290_09405	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JH290_09410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JH290_09425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JH290_09435	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JH290_09440	COG3734	2-keto-3-deoxy-galactonokinase
JH290_09455	COG0800	Aldolase
JH290_09495	COG1501	Belongs to the glycosyl hydrolase 31 family
JH290_09505	COG1070	Carbohydrate kinase
JH290_09515	COG0477	Major facilitator Superfamily
JH290_09535	COG0860	N-Acetylmuramoyl-L-alanine amidase
JH290_09590	COG1472	Belongs to the glycosyl hydrolase 3 family
JH290_09600	COG2203	Gaf domain
JH290_09600	COG3706	GGDEF domain
JH290_09600	COG4251	negative regulation of phosphorylation
JH290_09600	COG5001	Diguanylate cyclase
JH290_09605	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
JH290_09610	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
JH290_09625	COG0671	phosphoesterase, PA-phosphatase related
JH290_09635	COG1794	racemase activity, acting on amino acids and derivatives
JH290_09640	COG0697	spore germination
JH290_09665	COG1012	belongs to the aldehyde dehydrogenase family
JH290_09685	COG3039	Transposase
JH290_09745	COG3210	domain, Protein
JH290_09790	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JH290_09800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JH290_09830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JH290_09830	COG0131	Imidazoleglycerol-phosphate dehydratase
JH290_09850	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JH290_09850	COG0140	phosphoribosyl-ATP diphosphatase activity
JH290_09880	COG0531	amino acid
JH290_09885	COG0531	amino acid
JH290_09900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JH290_09905	COG0277	FAD linked oxidase domain protein
JH290_09940	COG1024	Enoyl-CoA hydratase
JH290_09965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JH290_09970	COG2258	MOSC domain
JH290_09980	COG0505	Belongs to the CarA family
JH290_09995	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JH290_10000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JH290_10010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JH290_10035	COG3279	Response regulator of the LytR AlgR family
JH290_10055	COG2205	protein histidine kinase activity
JH290_10055	COG0784	Response regulator, receiver
JH290_10055	COG2198	Histidine kinase
JH290_10060	COG0784	Response regulator, receiver
JH290_10060	COG2198	Histidine kinase
JH290_10060	COG2205	protein histidine kinase activity
JH290_10065	COG1024	Enoyl-CoA hydratase
JH290_10070	COG0318	PFAM AMP-dependent synthetase and ligase
JH290_10100	COG2267	carboxylic ester hydrolase activity
JH290_10125	COG0840	transmembrane signaling receptor activity
JH290_10135	COG0835	chemotaxis
JH290_10145	COG0840	transmembrane signaling receptor activity
JH290_10155	COG0840	transmembrane signaling receptor activity
JH290_10160	COG0840	transmembrane signaling receptor activity
JH290_10165	COG0840	transmembrane signaling receptor activity
JH290_10170	COG0840	transmembrane signaling receptor activity
JH290_10175	COG0840	transmembrane signaling receptor activity
JH290_10180	COG0840	transmembrane signaling receptor activity
JH290_10190	COG0840	transmembrane signaling receptor activity
JH290_10200	COG0745	RESPONSE REGULATOR receiver
JH290_10210	COG0835	chemotaxis
JH290_10215	COG1192	Involved in chromosome partitioning
JH290_10220	COG1360	Flagellar Motor Protein
JH290_10225	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JH290_10230	COG3039	Transposase
JH290_10300	COG0784	Response regulator, receiver
JH290_10300	COG2198	Histidine kinase
JH290_10300	COG0643	Histidine kinase
JH290_10330	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JH290_10355	COG1684	flagellar biosynthetic protein fliR
JH290_10420	COG1677	Flagellar hook-basal body complex protein FliE
JH290_10425	COG1216	Glycosyl transferase, family 2
JH290_10425	COG0438	transferase activity, transferring glycosyl groups
JH290_10455	COG2201	protein-glutamate methylesterase activity
JH290_10485	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
JH290_10495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JH290_10525	COG4787	bacterial-type flagellum-dependent cell motility
JH290_10535	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
JH290_10540	COG1558	bacterial-type flagellum-dependent cell motility
JH290_10550	COG0835	chemotaxis
JH290_10550	COG0784	Response regulator, receiver
JH290_10570	COG4191	Histidine kinase
JH290_10605	COG2915	High frequency lysogenization protein hflD homolog
JH290_10625	COG0542	response to heat
JH290_10645	COG0492	ferredoxin-NADP+ reductase activity
JH290_10650	COG1674	ftsk spoiiie
JH290_10660	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JH290_10675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JH290_10680	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JH290_10685	COG0183	Belongs to the thiolase family
JH290_10690	COG1024	Enoyl-CoA hydratase
JH290_10690	COG1250	3-hydroxyacyl-CoA dehydrogenase
JH290_10715	COG1426	Protein conserved in bacteria
JH290_10725	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JH290_10740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JH290_10755	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_10785	COG0708	Exodeoxyribonuclease III
JH290_10795	COG0303	'Molybdopterin
JH290_10800	COG0746	molybdenum cofactor guanylyltransferase activity
JH290_10810	COG1648	precorrin-2 dehydrogenase activity
JH290_10810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JH290_10825	COG2223	nitrite transmembrane transporter activity
JH290_10830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JH290_10840	COG0243	molybdopterin cofactor binding
JH290_10860	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
JH290_10870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JH290_10880	COG0579	oxidoreductase
JH290_10895	COG3685	Protein conserved in bacteria
JH290_10900	COG2201	protein-glutamate methylesterase activity
JH290_10915	COG5001	Diguanylate cyclase
JH290_10985	COG3590	peptidase
JH290_11000	COG1999	signal sequence binding
JH290_11020	COG1733	regulation of RNA biosynthetic process
JH290_11050	COG1238	metal cluster binding
JH290_11060	COG0840	transmembrane signaling receptor activity
JH290_11120	COG0784	Response regulator, receiver
JH290_11120	COG4191	Histidine kinase
JH290_11130	COG3459	Glycosyltransferase 36 associated
JH290_11170	COG0428	transporter
JH290_11180	COG1530	ribonuclease E activity
JH290_11210	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
JH290_11240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JH290_11255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JH290_11275	COG0848	biopolymer transport protein
JH290_11280	COG0811	peptide transport
JH290_11300	COG4591	ABC-type transport system involved in lipoprotein release permease component
JH290_11315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JH290_11325	COG1053	succinate dehydrogenase
JH290_11330	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
JH290_11355	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JH290_11365	COG0363	glucosamine-6-phosphate deaminase activity
JH290_11370	COG0129	dihydroxy-acid dehydratase activity
JH290_11375	COG0800	Aldolase
JH290_11460	COG0582	viral genome integration into host DNA
JH290_11475	COG5001	Diguanylate cyclase
JH290_11480	COG2183	response to ionizing radiation
JH290_11505	COG3243	poly(R)-hydroxyalkanoic acid synthase
JH290_11515	COG1183	phosphatidylcholine synthase activity
JH290_11520	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_11545	COG0668	transmembrane transport
JH290_11565	COG1914	H( )-stimulated, divalent metal cation uptake system
JH290_11575	COG2814	Major facilitator Superfamily
JH290_11590	COG1335	isochorismatase
JH290_11605	COG2197	response regulator
JH290_11645	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JH290_11660	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
JH290_11675	COG0539	negative regulation of cytoplasmic translation
JH290_11695	COG2957	Belongs to the agmatine deiminase family
JH290_11700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JH290_11725	COG0395	ABC-type sugar transport system, permease component
JH290_11735	COG2182	Extracellular solute-binding protein
JH290_11760	COG2350	Protein conserved in bacteria
JH290_11765	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JH290_11770	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JH290_11775	COG1187	pseudouridine synthase activity
JH290_11795	COG0436	Aminotransferase
JH290_11855	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JH290_11860	COG4988	ABC transporter
JH290_11870	COG1294	oxidase, subunit
JH290_11910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JH290_11940	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JH290_11945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JH290_11950	COG0137	argininosuccinate synthase activity
JH290_11960	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JH290_11975	COG2166	iron-sulfur cluster assembly
JH290_12000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JH290_12020	COG4302	ethanolamine ammonia-lyase activity
JH290_12070	COG0402	S-adenosylhomocysteine deaminase activity
JH290_12085	COG1509	lysine 2,3-aminomutase activity
JH290_12090	COG3300	MHYT domain
JH290_12090	COG5001	Diguanylate cyclase
JH290_12105	COG0483	inositol monophosphate 1-phosphatase activity
JH290_12110	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JH290_12125	COG0488	(ABC) transporter
JH290_12130	COG0513	Belongs to the DEAD box helicase family
JH290_12165	COG4681	YaeQ
JH290_12170	COG2081	HI0933 family
JH290_12175	COG3300	MHYT domain
JH290_12175	COG5001	Diguanylate cyclase
JH290_12190	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_12215	COG0860	N-Acetylmuramoyl-L-alanine amidase
JH290_12225	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JH290_12225	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JH290_12230	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JH290_12245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
JH290_12295	COG0835	chemotaxis
JH290_12300	COG0840	transmembrane signaling receptor activity
JH290_12310	COG1201	RNA secondary structure unwinding
JH290_12325	COG2969	positive regulation of protein catabolic process
JH290_12330	COG0625	glutathione transferase activity
JH290_12335	COG2857	Cytochrome c1
JH290_12340	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JH290_12345	COG0723	plastoquinol--plastocyanin reductase activity
JH290_12350	COG0741	lytic transglycosylase activity
JH290_12370	COG1702	phosphate starvation-inducible protein PhoH
JH290_12390	COG4535	Mg2 and Co2 transporter CorC
JH290_12405	COG1012	belongs to the aldehyde dehydrogenase family
JH290_12415	COG1177	transmembrane transport
JH290_12420	COG1176	ABC-type spermidine putrescine transport system, permease component I
JH290_12430	COG3842	ATPase activity
JH290_12465	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JH290_12470	COG0174	glutamine synthetase
JH290_12475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JH290_12485	COG2703	oxygen carrier activity
JH290_12490	COG0477	Major facilitator Superfamily
JH290_12500	COG0243	molybdopterin cofactor binding
JH290_12510	COG2223	nitrite transmembrane transporter activity
JH290_12515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JH290_12525	COG2733	membrane
JH290_12530	COG0784	Response regulator, receiver
JH290_12530	COG5002	protein histidine kinase activity
JH290_12530	COG2205	protein histidine kinase activity
JH290_12540	COG0477	Major facilitator Superfamily
JH290_12560	COG2902	Dehydrogenase
JH290_12570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JH290_12575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JH290_12580	COG1609	Transcriptional regulator
JH290_12585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JH290_12585	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JH290_12590	COG1105	Belongs to the carbohydrate kinase PfkB family
JH290_12595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JH290_12595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JH290_12655	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JH290_12665	COG1862	Preprotein translocase
JH290_12685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JH290_12715	COG3291	Pkd domain containing protein
JH290_12720	COG0405	Gamma-glutamyltransferase
JH290_12725	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JH290_12745	COG0742	ribosomal rna small subunit methyltransferase
JH290_12750	COG0326	Molecular chaperone. Has ATPase activity
JH290_12785	COG4206	TonB-dependent receptor
JH290_12825	COG0531	amino acid
JH290_12850	COG0006	proline dipeptidase activity
JH290_12860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JH290_12880	COG3938	Belongs to the proline racemase family
JH290_12890	COG0552	protein localization to endoplasmic reticulum
JH290_12910	COG0784	Response regulator, receiver
JH290_12910	COG4191	Histidine kinase
JH290_12920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JH290_12940	COG0322	excinuclease ABC activity
JH290_12965	COG1960	acyl-CoA dehydrogenase activity
JH290_12995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JH290_13005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JH290_13030	COG0438	transferase activity, transferring glycosyl groups
JH290_13035	COG2244	polysaccharide biosynthetic process
JH290_13045	COG0438	transferase activity, transferring glycosyl groups
JH290_13115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JH290_13130	COG3039	Transposase
JH290_13150	COG1082	Xylose isomerase domain protein TIM barrel
JH290_13165	COG0366	Alpha amylase catalytic
JH290_13225	COG3702	type iv secretory pathway
JH290_13245	COG2948	multi-organism process
JH290_13255	COG3736	Type IV secretory pathway, component VirB8
JH290_13265	COG3505	Type IV secretory pathway VirD4
JH290_13325	COG1611	Belongs to the LOG family
JH290_13335	COG2095	MarC family integral membrane protein
JH290_13345	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JH290_13405	COG0195	Participates in both transcription termination and antitermination
JH290_13420	COG1007	ATP synthesis coupled electron transport
JH290_13440	COG0839	Belongs to the complex I subunit 6 family
JH290_13460	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
JH290_13465	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
JH290_13485	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JH290_13505	COG4221	oxidoreductase activity
JH290_13590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JH290_13595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JH290_13610	COG2890	protein-(glutamine-N5) methyltransferase activity
JH290_13635	COG0433	COG0433 Predicted ATPase
JH290_13645	COG0494	nUDIX hydrolase
JH290_13660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JH290_13690	COG0717	Belongs to the dCTP deaminase family
JH290_13695	COG0489	protein tyrosine kinase activity
JH290_13700	COG4206	TonB-dependent receptor
JH290_13720	COG3590	peptidase
JH290_13740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JH290_13745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JH290_13750	COG2311	Membrane
JH290_13755	COG1047	Peptidyl-prolyl cis-trans
JH290_13760	COG0791	NLP P60 protein
JH290_13765	COG0791	NLP P60 protein
JH290_13795	COG4191	Histidine kinase
JH290_13810	COG4106	trans-aconitate 2-methyltransferase activity
JH290_13815	COG1301	dicarboxylic acid transport
JH290_13820	COG1785	Belongs to the alkaline phosphatase family
JH290_13835	COG0142	geranyltranstransferase activity
JH290_13840	COG4104	PAAR repeat-containing protein
JH290_13850	COG0312	modulator of DNA gyrase
JH290_13860	COG0312	modulator of DNA gyrase
JH290_13870	COG3164	Protein of unknown function
JH290_13885	COG2968	Membrane
JH290_13915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JH290_13940	COG3118	belongs to the thioredoxin family
JH290_13950	COG2155	Conserved Protein
JH290_14005	COG1132	(ABC) transporter
JH290_14010	COG0475	glutathione-regulated potassium exporter activity
JH290_14035	COG1187	pseudouridine synthase activity
JH290_14040	COG5001	Diguanylate cyclase
JH290_14040	COG5002	protein histidine kinase activity
JH290_14140	COG1294	oxidase, subunit
JH290_14145	COG1271	oxidase subunit
JH290_14155	COG3383	formate dehydrogenase (NAD+) activity
JH290_14165	COG1404	Belongs to the peptidase S8 family
JH290_14185	COG2814	Major facilitator Superfamily
JH290_14190	COG0583	DNA-binding transcription factor activity
JH290_14210	COG2207	Transcriptional regulator
JH290_14225	COG0667	Aldo Keto reductase
JH290_14230	COG1309	transcriptional regulator
JH290_14240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JH290_14255	COG0735	belongs to the Fur family
JH290_14290	COG4452	Inner membrane protein CreD
JH290_14300	COG2205	protein histidine kinase activity
JH290_14305	COG0745	RESPONSE REGULATOR receiver
JH290_14310	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
JH290_14325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JH290_14345	COG2198	Histidine kinase
JH290_14345	COG0643	Histidine kinase
JH290_14350	COG0840	transmembrane signaling receptor activity
JH290_14355	COG0835	chemotaxis
JH290_14365	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JH290_14380	COG3590	peptidase
JH290_14400	COG1741	Belongs to the pirin family
JH290_14420	COG1741	Belongs to the pirin family
JH290_14425	COG1966	Carbon starvation protein
JH290_14430	COG2879	small protein
JH290_14465	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
JH290_14470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JH290_14475	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
JH290_14480	COG2080	2 iron, 2 sulfur cluster binding
JH290_14485	COG0604	alcohol dehydrogenase
JH290_14490	COG2203	Gaf domain
JH290_14490	COG3706	GGDEF domain
JH290_14490	COG4251	negative regulation of phosphorylation
JH290_14490	COG5001	Diguanylate cyclase
JH290_14500	COG3039	Transposase
JH290_14510	COG1401	restriction endodeoxyribonuclease activity
JH290_14520	COG0629	single-stranded DNA binding
JH290_14525	COG0142	geranyltranstransferase activity
JH290_14550	COG0527	aspartate kinase activity
JH290_14555	COG0384	phenazine biosynthesis protein PhzF
JH290_14560	COG0384	phenazine biosynthesis protein PhzF
JH290_14570	COG1764	response to oxidative stress
JH290_14590	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
JH290_14595	COG0519	Catalyzes the synthesis of GMP from XMP
JH290_14625	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JH290_14660	COG0693	protein deglycase activity
JH290_14675	COG0719	Fe-S assembly protein
JH290_14685	COG0396	ATPase activity
JH290_14690	COG0719	Fe-S assembly protein
JH290_14695	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JH290_14705	COG2146	nitrite reductase [NAD(P)H] activity
JH290_14710	COG4774	siderophore transport
JH290_14755	COG1555	photosystem II stabilization
JH290_14760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JH290_14775	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JH290_14785	COG0628	permease
JH290_14805	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JH290_14830	COG0271	Belongs to the BolA IbaG family
JH290_14840	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
JH290_14855	COG1137	ATPase activity
JH290_14870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JH290_14890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JH290_14895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JH290_14900	COG2239	Acts as a magnesium transporter
JH290_14910	COG1294	oxidase, subunit
JH290_14915	COG1271	oxidase subunit
JH290_14920	COG1113	amino acid transport
JH290_14940	COG2197	response regulator
JH290_14945	COG0531	amino acid
JH290_15015	COG2814	Major facilitator Superfamily
JH290_15025	COG0754	glutathionylspermidine amidase activity
JH290_15050	COG1842	Phage shock protein A
JH290_15085	COG0477	Major facilitator Superfamily
JH290_15105	COG2353	YceI-like domain
JH290_15125	COG1760	l-serine dehydratase
JH290_15140	COG0460	homoserine dehydrogenase
JH290_15140	COG0527	aspartate kinase activity
JH290_15145	COG0626	cystathionine gamma-synthase activity
JH290_15150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JH290_15165	COG1272	protein, Hemolysin III
JH290_15170	COG2982	Protein involved in outer membrane biogenesis
JH290_15175	COG0517	IMP dehydrogenase activity
JH290_15175	COG0516	GMP reductase activity
JH290_15180	COG0463	Glycosyl transferase, family 2
JH290_15190	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JH290_15200	COG4206	TonB-dependent receptor
JH290_15205	COG1309	transcriptional regulator
JH290_15215	COG1960	acyl-CoA dehydrogenase activity
JH290_15265	COG0330	HflC and HflK could
JH290_15275	COG3956	TIGRFAM MazG family protein
JH290_15280	COG1218	3'(2'),5'-bisphosphate nucleotidase
JH290_15285	COG0494	nUDIX hydrolase
JH290_15295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JH290_15300	COG0837	glucose binding
JH290_15315	COG1388	LysM domain
JH290_15315	COG3858	chitin binding
JH290_15320	COG3525	Glycosyl hydrolase, family 20, catalytic domain
JH290_15330	COG1472	Belongs to the glycosyl hydrolase 3 family
JH290_15340	COG3537	Alpha-1,2-mannosidase
JH290_15365	COG3039	Transposase
JH290_15375	COG3039	Transposase
JH290_15405	COG3645	SOS response
JH290_15420	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JH290_15460	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JH290_15475	COG1446	asparaginase
JH290_15480	COG2304	oxidoreductase activity
JH290_15485	COG1595	DNA-templated transcription, initiation
JH290_15510	COG2198	Histidine kinase
JH290_15510	COG0784	Response regulator, receiver
JH290_15510	COG0643	Histidine kinase
JH290_15515	COG0840	transmembrane signaling receptor activity
JH290_15520	COG0835	chemotaxis
JH290_15535	COG0189	ligase activity
JH290_15545	COG1397	ADP-ribosylglycohydrolase
JH290_15560	COG1199	ATP-dependent helicase activity
JH290_15570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JH290_15575	COG1215	transferase activity, transferring glycosyl groups
JH290_15585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JH290_15635	COG1643	Atp-dependent helicase
JH290_15640	COG0783	Belongs to the Dps family
JH290_15645	COG0514	ATP-dependent DNA helicase (RecQ)
JH290_15660	COG1187	pseudouridine synthase activity
JH290_15730	COG0602	queuosine metabolic process
JH290_15740	COG2885	chlorophyll binding
JH290_15755	COG0848	biopolymer transport protein
JH290_15765	COG0824	Thioesterase
JH290_15835	COG0477	Major facilitator Superfamily
JH290_15855	COG0657	acetylesterase activity
JH290_15855	COG2755	lipolytic protein G-D-S-L family
JH290_15880	COG0488	(ABC) transporter
JH290_15910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JH290_15910	COG4651	solute:proton antiporter activity
JH290_15940	COG4772	TonB-dependent receptor
JH290_15950	COG4264	IucA IucC family
JH290_15955	COG2814	Major facilitator Superfamily
JH290_15960	COG4264	IucA IucC family
JH290_15965	COG0019	diaminopimelate decarboxylase activity
JH290_15975	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
JH290_16005	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
JH290_16010	COG1797	cobyrinic acid a,c-diamide synthase activity
JH290_16030	COG4206	TonB-dependent receptor
JH290_16045	COG0542	response to heat
JH290_16050	COG1116	anion transmembrane transporter activity
JH290_16095	COG1877	trehalose-phosphatase activity
JH290_16100	COG3387	PFAM Glycoside hydrolase 15-related
JH290_16115	COG0840	transmembrane signaling receptor activity
JH290_16135	COG0564	pseudouridine synthase activity
JH290_16140	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JH290_16150	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JH290_16150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JH290_16215	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
JH290_16245	COG0745	RESPONSE REGULATOR receiver
JH290_16335	COG2003	Belongs to the UPF0758 family
JH290_16455	COG0471	metal ion transport
JH290_16455	COG3273	potassium ion transport
JH290_16485	COG1609	Transcriptional regulator
JH290_16495	COG5297	Belongs to the glycosyl hydrolase family 6
JH290_16505	COG3250	beta-galactosidase activity
JH290_16510	COG4948	Mandelate Racemase Muconate Lactonizing
JH290_16525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JH290_16530	COG1115	amino acid carrier protein
JH290_16540	COG0308	aminopeptidase N
JH290_16545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JH290_16550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JH290_16555	COG2895	sulfate adenylyltransferase (ATP) activity
JH290_16555	COG0529	Catalyzes the synthesis of activated sulfate
JH290_16565	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JH290_16595	COG2205	protein histidine kinase activity
JH290_16595	COG2198	Histidine kinase
JH290_16595	COG0784	Response regulator, receiver
JH290_16625	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
JH290_16630	COG3588	fructose-bisphosphate aldolase
JH290_16635	COG0469	pyruvate kinase activity
JH290_16665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JH290_16680	COG3047	cAMP biosynthetic process
JH290_16695	COG3453	Protein conserved in bacteria
JH290_16695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JH290_16700	COG0725	ABC transporter, periplasmic molybdate-binding protein
JH290_16705	COG4149	molybdate abc transporter
JH290_16750	COG1376	ErfK ybiS ycfS ynhG family protein
JH290_16755	COG0739	heme binding
JH290_16760	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_16765	COG0583	DNA-binding transcription factor activity
JH290_16775	COG0596	Alpha beta hydrolase
JH290_16780	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JH290_16785	COG1301	dicarboxylic acid transport
JH290_16815	COG0714	Associated with various cellular activities
JH290_16845	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JH290_16870	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JH290_16880	COG2721	sulfolactate sulfo-lyase activity
JH290_16895	COG2271	Major facilitator Superfamily
JH290_16910	COG0583	DNA-binding transcription factor activity
JH290_16920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JH290_16935	COG1561	YicC-like family, N-terminal region
JH290_16945	COG0346	lactoylglutathione lyase activity
JH290_16955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JH290_16980	COG0006	proline dipeptidase activity
JH290_17005	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JH290_17025	COG2912	Transglutaminase-like superfamily
JH290_17030	COG1773	rubredoxin
JH290_17060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JH290_17090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JH290_17095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JH290_17105	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_17115	COG0671	phosphoesterase, PA-phosphatase related
JH290_17120	COG3781	membrane
JH290_17130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JH290_17155	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
JH290_17165	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JH290_17185	COG3710	Transcriptional regulator
JH290_17195	COG0823	Involved in the tonB-independent uptake of proteins
JH290_17195	COG1506	peptidase
JH290_17195	COG4946	Tricorn protease homolog
JH290_17200	COG0840	transmembrane signaling receptor activity
JH290_17205	COG0405	Gamma-glutamyltransferase
JH290_17240	COG2226	methyltransferase
JH290_17250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JH290_17260	COG5001	Diguanylate cyclase
JH290_17260	COG3300	MHYT domain
JH290_17270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JH290_17275	COG1538	Outer membrane efflux protein
JH290_17280	COG1519	Transferase
JH290_17285	COG1560	Kdo2-lipid A biosynthetic process
JH290_17325	COG4191	Histidine kinase
JH290_17335	COG2197	response regulator
JH290_17345	COG0642	Histidine kinase
JH290_17360	COG2851	Citrate transporter
JH290_17365	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_17370	COG1609	Transcriptional regulator
JH290_17375	COG2211	Major facilitator Superfamily
JH290_17405	COG0436	Aminotransferase
JH290_17425	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JH290_17445	COG0402	S-adenosylhomocysteine deaminase activity
JH290_17480	COG1307	EDD domain protein, DegV family
JH290_17490	COG0697	spore germination
JH290_17530	COG0583	DNA-binding transcription factor activity
JH290_17550	COG2205	protein histidine kinase activity
JH290_17585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JH290_17625	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JH290_17630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JH290_17635	COG1609	Transcriptional regulator
JH290_17645	COG2188	Transcriptional regulator
JH290_17670	COG4795	General secretion pathway protein
JH290_17675	COG2165	general secretion pathway protein
JH290_17690	COG1459	type II secretion system
JH290_17735	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_17740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JH290_17745	COG4191	Histidine kinase
JH290_17750	COG0784	Response regulator, receiver
JH290_17755	COG4251	negative regulation of phosphorylation
JH290_17760	COG2823	Periplasmic or secreted lipoprotein
JH290_17765	COG0673	inositol 2-dehydrogenase activity
JH290_17770	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
JH290_17805	COG1051	belongs to the nudix hydrolase family
JH290_17805	COG1056	cytidyltransferase-related domain
JH290_17850	COG1686	Belongs to the peptidase S11 family
JH290_17855	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JH290_17860	COG2951	lytic endotransglycosylase activity
JH290_17890	COG0772	Belongs to the SEDS family
JH290_17905	COG1792	Involved in formation and maintenance of cell shape
JH290_17910	COG1077	Cell shape determining protein MreB Mrl
JH290_17915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JH290_17920	COG3284	Transcriptional regulator
JH290_17930	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
JH290_17965	COG0308	aminopeptidase N
JH290_17970	COG5001	Diguanylate cyclase
JH290_17970	COG3300	MHYT domain
JH290_17975	COG2226	methyltransferase
JH290_18010	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JH290_18040	COG2832	Protein of unknown function (DUF454)
JH290_18050	COG0436	Aminotransferase
JH290_18065	COG1505	serine-type exopeptidase activity
JH290_18105	COG3275	phosphorelay sensor kinase activity
JH290_18120	COG3273	potassium ion transport
JH290_18120	COG0471	metal ion transport
JH290_18135	COG3706	GGDEF domain
JH290_18140	COG0659	secondary active sulfate transmembrane transporter activity
JH290_18145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
JH290_18145	COG5297	Belongs to the glycosyl hydrolase family 6
JH290_18150	COG0840	transmembrane signaling receptor activity
JH290_18155	COG3039	Transposase
JH290_18160	COG3447	MASE1 domain protein
JH290_18160	COG5002	protein histidine kinase activity
JH290_18160	COG5001	Diguanylate cyclase
JH290_18220	COG1113	amino acid transport
JH290_18230	COG5297	Belongs to the glycosyl hydrolase family 6
JH290_18235	COG4305	rare lipoprotein A
JH290_18250	COG0697	spore germination
JH290_18280	COG1959	2 iron, 2 sulfur cluster binding
JH290_18295	COG0823	Involved in the tonB-independent uptake of proteins
JH290_18295	COG1506	peptidase
JH290_18305	COG2409	Drug exporters of the RND superfamily
JH290_18470	COG1802	Transcriptional regulator
JH290_18525	COG2353	YceI-like domain
JH290_18595	COG3712	iron ion homeostasis
JH290_18610	COG3386	PFAM SMP-30 Gluconolaconase
JH290_18635	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JH290_18650	COG3039	Transposase
JH290_18690	COG2356	endonuclease I
JH290_18695	COG1324	tolerance protein
JH290_18725	COG0511	ligase activity, forming carbon-carbon bonds
JH290_18735	COG0439	Biotin carboxylase
JH290_18770	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
JH290_18775	COG4589	Belongs to the CDS family
JH290_18805	COG2267	carboxylic ester hydrolase activity
JH290_18810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JH290_18825	COG0151	Belongs to the GarS family
JH290_18830	COG1289	transmembrane transporter activity
JH290_18840	COG2814	Major facilitator Superfamily
JH290_18875	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
JH290_18880	COG2816	NAD+ diphosphatase activity
JH290_18985	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JH290_19000	COG0436	Aminotransferase
JH290_19075	COG2111	Na H antiporter
JH290_19075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JH290_19080	COG1006	Multisubunit Na H antiporter MnhC subunit
JH290_19085	COG0651	ATP synthesis coupled electron transport
JH290_19095	COG2212	antiporter activity
JH290_19100	COG1320	monovalent cation:proton antiporter activity
JH290_19125	COG2852	Protein conserved in bacteria
JH290_19145	COG3104	oligopeptide transport
JH290_19160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JH290_19175	COG0508	dehydrogenase complex catalyzes the overall conversion of
JH290_19185	COG0513	Belongs to the DEAD box helicase family
JH290_19230	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_19235	COG0702	epimerase
JH290_19260	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JH290_19270	COG0297	glycogen (starch) synthase activity
JH290_19280	COG1649	PFAM Uncharacterised BCR, COG1649
JH290_19285	COG2354	Protein conserved in bacteria
JH290_19290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JH290_19300	COG3264	Mechanosensitive ion channel
JH290_19300	COG1511	domain protein
JH290_19330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JH290_19335	COG4774	siderophore transport
JH290_19360	COG1040	competence protein
JH290_19410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JH290_19430	COG0657	acetylesterase activity
JH290_19440	COG1414	Transcriptional regulator
JH290_19450	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JH290_19455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JH290_19465	COG3485	protocatechuate 3,4-dioxygenase
JH290_19470	COG3485	protocatechuate 3,4-dioxygenase
JH290_19480	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
JH290_19485	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
JH290_19510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JH290_19570	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JH290_19670	COG0840	transmembrane signaling receptor activity
JH290_19680	COG1733	regulation of RNA biosynthetic process
JH290_19685	COG0702	epimerase
JH290_19715	COG0583	DNA-binding transcription factor activity
JH290_19720	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JH290_19745	COG1902	pentaerythritol trinitrate reductase activity
JH290_19765	COG2814	Major facilitator Superfamily
JH290_19770	COG0583	DNA-binding transcription factor activity
JH290_19780	COG0084	hydrolase, TatD family'
JH290_19800	COG2252	PERMEase
JH290_19810	COG1957	nucleoside hydrolase
JH290_19825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JH290_19850	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JH290_19870	COG2072	flavoprotein involved in K transport
JH290_19875	COG2351	hydroxyisourate hydrolase activity
JH290_19880	COG4807	Protein conserved in bacteria
JH290_19885	COG0840	transmembrane signaling receptor activity
JH290_19890	COG1643	Atp-dependent helicase
JH290_19900	COG1187	pseudouridine synthase activity
JH290_19915	COG2130	NADP-dependent
JH290_19920	COG0656	L-ascorbic acid biosynthetic process
JH290_19950	COG1764	response to oxidative stress
JH290_19955	COG1846	Transcriptional regulator
JH290_19965	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
JH290_19975	COG0697	spore germination
JH290_20040	COG1960	acyl-CoA dehydrogenase activity
JH290_20045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JH290_20050	COG4770	biotin carboxylase activity
JH290_20080	COG2224	Isocitrate lyase
JH290_20085	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
JH290_20090	COG0583	DNA-binding transcription factor activity
JH290_20110	COG0339	signal peptide processing
JH290_20115	COG1446	asparaginase
JH290_20135	COG0564	pseudouridine synthase activity
JH290_20150	COG1181	Belongs to the D-alanine--D-alanine ligase family
JH290_20165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JH290_20170	COG0318	PFAM AMP-dependent synthetase and ligase
JH290_20175	COG0727	PFAM Uncharacterised protein family (UPF0153)
JH290_20180	COG0596	Alpha beta hydrolase
JH290_20195	COG3177	Filamentation induced by cAMP protein fic
JH290_20200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JH290_20215	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JH290_20230	COG0028	Belongs to the TPP enzyme family
JH290_20250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JH290_20290	COG0183	Belongs to the thiolase family
JH290_20300	COG0346	lactoylglutathione lyase activity
JH290_20305	COG2032	superoxide dismutase activity
JH290_20310	COG2032	superoxide dismutase activity
JH290_20320	COG2204	response regulator
JH290_20325	COG3852	Histidine kinase
JH290_20330	COG0004	ammonium transporteR
JH290_20335	COG0347	Belongs to the P(II) protein family
JH290_20340	COG0174	glutamine synthetase
JH290_20380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JH290_20390	COG0588	phosphoglycerate mutase activity
JH290_20395	COG0489	protein tyrosine kinase activity
JH290_20425	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
JH290_20430	COG1262	PFAM Formylglycine-generating sulfatase enzyme
JH290_20445	COG1125	glycine betaine transport
JH290_20445	COG0517	IMP dehydrogenase activity
JH290_20460	COG1119	ATPase activity
JH290_20470	COG1752	Esterase of the alpha-beta hydrolase superfamily
JH290_20485	COG1522	sequence-specific DNA binding
JH290_20490	COG3186	Phenylalanine-4-hydroxylase
JH290_20500	COG2755	lipolytic protein G-D-S-L family
JH290_20510	COG1028	Short-chain dehydrogenase reductase Sdr
JH290_20520	COG1609	Transcriptional regulator
JH290_20525	COG3507	Belongs to the glycosyl hydrolase 43 family
JH290_20540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
JH290_20550	COG0657	acetylesterase activity
JH290_20550	COG2755	lipolytic protein G-D-S-L family
JH290_20560	COG2755	lipolytic protein G-D-S-L family
JH290_20605	COG0366	Alpha amylase catalytic
JH290_20610	COG0366	Alpha amylase catalytic
JH290_20715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JH290_20735	COG3710	Transcriptional regulator
JH290_20790	COG1012	belongs to the aldehyde dehydrogenase family
JH290_20800	COG4772	TonB-dependent receptor
JH290_20840	COG0714	Associated with various cellular activities
JH290_20880	COG0477	Major facilitator Superfamily
JH290_20885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JH290_20895	COG0657	acetylesterase activity
JH290_20900	COG0628	permease
JH290_20955	COG3237	CsbD-like
JH290_20960	COG3039	Transposase
JH290_21050	COG1272	protein, Hemolysin III
JH290_21055	COG3177	Filamentation induced by cAMP protein fic
JH290_21060	COG1111	helicase
JH290_21060	COG1205	dead DEAH box helicase
JH290_21115	COG0583	DNA-binding transcription factor activity
JH290_21135	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JH290_21255	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JH290_21315	COG3846	protein secretion by the type IV secretion system
JH290_21355	COG4962	Type ii secretion system protein e
JH290_21435	COG0067	glutamate synthase
JH290_21435	COG0069	glutamate synthase activity
JH290_21435	COG0070	glutamate synthase
JH290_21440	COG0493	'glutamate synthase
JH290_21450	COG1064	alcohol dehydrogenase
JH290_21455	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
JH290_21460	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
JH290_21465	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
JH290_21480	COG2234	aminopeptidase activity
JH290_21490	COG4942	peptidase
JH290_21500	COG0793	Belongs to the peptidase S41A family
JH290_21505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JH290_21535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JH290_21575	COG0501	Belongs to the peptidase M48B family
JH290_21585	COG0187	DNA topoisomerase II activity