locus-tag	class	description
KWO_000010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KWO_000025	COG0187	DNA topoisomerase II activity
KWO_000035	COG0501	Belongs to the peptidase M48B family
KWO_000065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KWO_000075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KWO_000110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KWO_000115	COG0793	Belongs to the peptidase S41A family
KWO_000120	COG4942	peptidase
KWO_000130	COG2234	aminopeptidase activity
KWO_000145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KWO_000155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KWO_000165	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KWO_000175	COG1064	alcohol dehydrogenase
KWO_000195	COG0493	'glutamate synthase
KWO_000200	COG0069	glutamate synthase activity
KWO_000200	COG0067	glutamate synthase
KWO_000200	COG0070	glutamate synthase
KWO_000285	COG1205	dead DEAH box helicase
KWO_000285	COG1111	helicase
KWO_000290	COG1272	protein, Hemolysin III
KWO_000320	COG2249	NAD(P)H dehydrogenase (quinone) activity
KWO_000350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KWO_000405	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
KWO_000415	COG4772	TonB-dependent receptor
KWO_000440	COG1304	FMN binding
KWO_000470	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KWO_000505	COG2831	hemolysin activation secretion protein
KWO_000515	COG0366	Alpha amylase catalytic
KWO_000520	COG0366	Alpha amylase catalytic
KWO_000545	COG0657	acetylesterase activity
KWO_000545	COG2755	lipolytic protein G-D-S-L family
KWO_000555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KWO_000570	COG3507	Belongs to the glycosyl hydrolase 43 family
KWO_000575	COG1609	Transcriptional regulator
KWO_000580	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
KWO_000585	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_000595	COG2755	lipolytic protein G-D-S-L family
KWO_000605	COG3186	Phenylalanine-4-hydroxylase
KWO_000610	COG1522	sequence-specific DNA binding
KWO_000625	COG2951	lytic endotransglycosylase activity
KWO_000630	COG1752	Esterase of the alpha-beta hydrolase superfamily
KWO_000635	COG1473	amidohydrolase
KWO_000645	COG1119	ATPase activity
KWO_000660	COG0517	IMP dehydrogenase activity
KWO_000660	COG1125	glycine betaine transport
KWO_000675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KWO_000715	COG0489	protein tyrosine kinase activity
KWO_000720	COG2062	phosphohistidine phosphatase, SixA
KWO_000730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KWO_000790	COG0174	glutamine synthetase
KWO_000795	COG0347	Belongs to the P(II) protein family
KWO_000800	COG0004	ammonium transporteR
KWO_000805	COG3852	Histidine kinase
KWO_000810	COG2204	response regulator
KWO_000815	COG2032	superoxide dismutase activity
KWO_000830	COG0346	lactoylglutathione lyase activity
KWO_000840	COG0183	Belongs to the thiolase family
KWO_000880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KWO_000885	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KWO_000890	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KWO_000900	COG0028	Belongs to the TPP enzyme family
KWO_000905	COG2205	protein histidine kinase activity
KWO_000930	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KWO_000945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KWO_000950	COG3177	Filamentation induced by cAMP protein fic
KWO_000965	COG0596	Alpha beta hydrolase
KWO_000975	COG0318	PFAM AMP-dependent synthetase and ligase
KWO_000980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KWO_001000	COG1181	Belongs to the D-alanine--D-alanine ligase family
KWO_001020	COG0564	pseudouridine synthase activity
KWO_001040	COG1446	asparaginase
KWO_001045	COG0339	signal peptide processing
KWO_001075	COG0475	glutathione-regulated potassium exporter activity
KWO_001085	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KWO_001090	COG2224	Isocitrate lyase
KWO_001095	COG3706	GGDEF domain
KWO_001125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KWO_001130	COG1960	acyl-CoA dehydrogenase activity
KWO_001195	COG0697	spore germination
KWO_001205	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KWO_001215	COG1846	Transcriptional regulator
KWO_001220	COG1764	response to oxidative stress
KWO_001260	COG1187	pseudouridine synthase activity
KWO_001270	COG1643	Atp-dependent helicase
KWO_001275	COG4807	Protein conserved in bacteria
KWO_001280	COG2351	hydroxyisourate hydrolase activity
KWO_001285	COG2072	flavoprotein involved in K transport
KWO_001305	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KWO_001350	COG2252	PERMEase
KWO_001370	COG0084	hydrolase, TatD family'
KWO_001405	COG2814	Major facilitator Superfamily
KWO_001410	COG4221	oxidoreductase activity
KWO_001420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KWO_001425	COG1902	pentaerythritol trinitrate reductase activity
KWO_001450	COG0745	RESPONSE REGULATOR receiver
KWO_001470	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KWO_001475	COG0583	DNA-binding transcription factor activity
KWO_001510	COG0702	epimerase
KWO_001515	COG1733	regulation of RNA biosynthetic process
KWO_001560	COG0129	dihydroxy-acid dehydratase activity
KWO_001575	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KWO_001640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KWO_001670	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KWO_001675	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KWO_001685	COG3485	protocatechuate 3,4-dioxygenase
KWO_001690	COG3485	protocatechuate 3,4-dioxygenase
KWO_001705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KWO_001710	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KWO_001715	COG1414	Transcriptional regulator
KWO_001730	COG0445	tRNA wobble uridine modification
KWO_001785	COG0156	8-amino-7-oxononanoate synthase activity
KWO_001795	COG1040	competence protein
KWO_001830	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KWO_001925	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KWO_002000	COG3264	Mechanosensitive ion channel
KWO_002000	COG1511	domain protein
KWO_002015	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KWO_002020	COG2354	Protein conserved in bacteria
KWO_002030	COG3706	GGDEF domain
KWO_002030	COG0745	RESPONSE REGULATOR receiver
KWO_002035	COG0297	glycogen (starch) synthase activity
KWO_002040	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KWO_002045	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KWO_002070	COG0702	epimerase
KWO_002100	COG0513	Belongs to the DEAD box helicase family
KWO_002115	COG0508	dehydrogenase complex catalyzes the overall conversion of
KWO_002130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KWO_002150	COG3104	oligopeptide transport
KWO_002170	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
KWO_002230	COG1320	monovalent cation:proton antiporter activity
KWO_002235	COG2212	antiporter activity
KWO_002245	COG0651	ATP synthesis coupled electron transport
KWO_002250	COG1006	Multisubunit Na H antiporter MnhC subunit
KWO_002255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KWO_002255	COG2111	Na H antiporter
KWO_002310	COG3039	Transposase
KWO_002325	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KWO_002330	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KWO_002340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KWO_002345	COG0456	acetyltransferase
KWO_002350	COG1597	lipid kinase activity
KWO_002380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KWO_002385	COG0134	indole-3-glycerol-phosphate synthase activity
KWO_002395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KWO_002415	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KWO_002455	COG0745	RESPONSE REGULATOR receiver
KWO_002475	COG0316	Belongs to the HesB IscA family
KWO_002500	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
KWO_002520	COG2814	Major facilitator Superfamily
KWO_002530	COG2814	Major facilitator Superfamily
KWO_002535	COG1289	transmembrane transporter activity
KWO_002540	COG0151	Belongs to the GarS family
KWO_002550	COG0419	ATPase involved in DNA repair
KWO_002555	COG0138	bifunctional purine biosynthesis protein purh
KWO_002580	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KWO_002630	COG0439	Biotin carboxylase
KWO_002640	COG0511	ligase activity, forming carbon-carbon bonds
KWO_002645	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KWO_002655	COG1324	tolerance protein
KWO_002665	COG2356	endonuclease I
KWO_002675	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KWO_002700	COG4771	TonB-dependent receptor
KWO_002705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KWO_002725	COG3386	PFAM SMP-30 Gluconolaconase
KWO_002735	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KWO_002785	COG0778	Nitroreductase
KWO_002790	COG2353	YceI-like domain
KWO_002830	COG3052	prosthetic group binding
KWO_002855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KWO_002855	COG3321	synthase
KWO_002865	COG1802	Transcriptional regulator
KWO_002870	COG0546	phosphoglycolate phosphatase activity
KWO_003020	COG4221	oxidoreductase activity
KWO_003025	COG0435	Glutathione S-transferase
KWO_003095	COG0697	spore germination
KWO_003115	COG4305	rare lipoprotein A
KWO_003125	COG1113	amino acid transport
KWO_003135	COG0598	Magnesium transport protein CorA
KWO_003210	COG5297	Belongs to the glycosyl hydrolase family 6
KWO_003210	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KWO_003215	COG0659	secondary active sulfate transmembrane transporter activity
KWO_003240	COG2943	transferase activity, transferring hexosyl groups
KWO_003250	COG3275	phosphorelay sensor kinase activity
KWO_003290	COG1505	serine-type exopeptidase activity
KWO_003315	COG2832	Protein of unknown function (DUF454)
KWO_003325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KWO_003335	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KWO_003350	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KWO_003375	COG2226	methyltransferase
KWO_003385	COG5001	Diguanylate cyclase
KWO_003385	COG3300	MHYT domain
KWO_003390	COG0308	aminopeptidase N
KWO_003420	COG3293	Transposase
KWO_003430	COG0730	response to heat
KWO_003435	COG1012	belongs to the aldehyde dehydrogenase family
KWO_003440	COG0367	asparagine synthase
KWO_003455	COG0028	Belongs to the TPP enzyme family
KWO_003455	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
KWO_003480	COG1077	Cell shape determining protein MreB Mrl
KWO_003485	COG1792	Involved in formation and maintenance of cell shape
KWO_003500	COG0772	Belongs to the SEDS family
KWO_003515	COG5297	Belongs to the glycosyl hydrolase family 6
KWO_003560	COG2951	lytic endotransglycosylase activity
KWO_003565	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KWO_003570	COG1686	Belongs to the peptidase S11 family
KWO_003580	COG2921	Belongs to the UPF0250 family
KWO_003585	COG0321	lipoyl(octanoyl) transferase activity
KWO_003590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KWO_003605	COG1051	belongs to the nudix hydrolase family
KWO_003605	COG1056	cytidyltransferase-related domain
KWO_003640	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KWO_003645	COG0673	inositol 2-dehydrogenase activity
KWO_003650	COG2823	Periplasmic or secreted lipoprotein
KWO_003655	COG4251	negative regulation of phosphorylation
KWO_003660	COG0784	Response regulator, receiver
KWO_003665	COG4191	Histidine kinase
KWO_003670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KWO_003675	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_003705	COG3250	beta-galactosidase activity
KWO_003730	COG1609	Transcriptional regulator
KWO_003735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KWO_003740	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KWO_003755	COG1215	transferase activity, transferring glycosyl groups
KWO_003760	COG0726	polysaccharide deacetylase
KWO_003760	COG1649	PFAM Uncharacterised BCR, COG1649
KWO_003810	COG0525	valine-tRNA ligase activity
KWO_003825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KWO_003835	COG0795	lipopolysaccharide-transporting ATPase activity
KWO_003845	COG4974	Belongs to the 'phage' integrase family
KWO_003850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KWO_003865	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KWO_003865	COG0047	phosphoribosylformylglycinamidine synthase activity
KWO_003875	COG5295	Hep Hag repeat protein
KWO_003885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KWO_003895	COG1459	type II secretion system
KWO_003900	COG2165	general secretion pathway protein
KWO_003905	COG4970	Tfp pilus assembly protein FimT
KWO_003910	COG2165	general secretion pathway protein
KWO_003915	COG4795	General secretion pathway protein
KWO_003920	COG3156	type II secretion system protein K
KWO_003925	COG3166	PFAM Fimbrial assembly family protein
KWO_003940	COG1450	Type ii and iii secretion system protein
KWO_003950	COG2188	Transcriptional regulator
KWO_004010	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KWO_004040	COG0242	peptide deformylase activity
KWO_004045	COG0488	(ABC) transporter
KWO_004070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KWO_004075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KWO_004085	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KWO_004085	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KWO_004105	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KWO_004115	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KWO_004160	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KWO_004165	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KWO_004175	COG2205	protein histidine kinase activity
KWO_004180	COG0745	RESPONSE REGULATOR receiver
KWO_004185	COG0277	FAD linked oxidase domain protein
KWO_004190	COG1988	membrane-bound metal-dependent
KWO_004240	COG0275	rRNA processing
KWO_004245	COG3116	cell division
KWO_004260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KWO_004265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KWO_004275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KWO_004280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KWO_004285	COG1181	Belongs to the D-alanine--D-alanine ligase family
KWO_004290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KWO_004305	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KWO_004315	COG0739	heme binding
KWO_004320	COG0653	protein targeting
KWO_004325	COG0494	nUDIX hydrolase
KWO_004340	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KWO_004350	COG3321	synthase
KWO_004350	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_004350	COG0604	alcohol dehydrogenase
KWO_004400	COG2226	methyltransferase
KWO_004415	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KWO_004445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KWO_004455	COG4106	trans-aconitate 2-methyltransferase activity
KWO_004460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KWO_004475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KWO_004480	COG0667	Aldo Keto reductase
KWO_004495	COG4771	TonB-dependent receptor
KWO_004515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KWO_004520	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
KWO_004530	COG2175	clavaminate synthase activity
KWO_004540	COG4181	ATPase activity
KWO_004555	COG0642	Histidine kinase
KWO_004570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KWO_004590	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KWO_004605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KWO_004610	COG2967	ApaG domain
KWO_004615	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KWO_004625	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KWO_004635	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KWO_004640	COG0123	including yeast histone deacetylase and acetoin utilization protein
KWO_004645	COG2096	Adenosyltransferase
KWO_004660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KWO_004665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KWO_004690	COG3384	dioxygenase
KWO_004695	COG0583	DNA-binding transcription factor activity
KWO_004700	COG0318	PFAM AMP-dependent synthetase and ligase
KWO_004710	COG1024	Enoyl-CoA hydratase
KWO_004730	COG3386	PFAM SMP-30 Gluconolaconase
KWO_004755	COG0697	spore germination
KWO_004765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KWO_004780	COG5002	protein histidine kinase activity
KWO_004780	COG2205	protein histidine kinase activity
KWO_004780	COG0784	Response regulator, receiver
KWO_004785	COG2197	response regulator
KWO_004795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KWO_004805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KWO_004810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KWO_004815	COG0583	DNA-binding transcription factor activity
KWO_004820	COG3634	alkyl hydroperoxide reductase activity
KWO_004830	COG2890	protein-(glutamine-N5) methyltransferase activity
KWO_004865	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWO_004865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KWO_004885	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
KWO_004930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KWO_004935	COG1404	Belongs to the peptidase S8 family
KWO_004940	COG1404	Belongs to the peptidase S8 family
KWO_004945	COG1404	Belongs to the peptidase S8 family
KWO_004950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KWO_004975	COG1295	ribonuclease BN
KWO_004980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KWO_005000	COG0521	Mo-molybdopterin cofactor biosynthetic process
KWO_005015	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KWO_005025	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KWO_005030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KWO_005040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KWO_005045	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KWO_005050	COG0193	aminoacyl-tRNA hydrolase activity
KWO_005055	COG0012	GTP binding
KWO_005075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KWO_005085	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KWO_005090	COG0250	Participates in transcription elongation, termination and antitermination
KWO_005095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KWO_005100	COG0081	regulation of translation
KWO_005105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KWO_005115	COG0085	RNA polymerase activity
KWO_005125	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KWO_005130	COG0049	tRNA binding
KWO_005135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KWO_005140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KWO_005155	COG0051	transcription antitermination factor activity, RNA binding
KWO_005165	COG0088	Forms part of the polypeptide exit tunnel
KWO_005175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KWO_005195	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KWO_005200	COG0255	Belongs to the universal ribosomal protein uL29 family
KWO_005205	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KWO_005210	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KWO_005215	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KWO_005225	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KWO_005245	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KWO_005250	COG1841	ribosomal large subunit assembly
KWO_005255	COG0200	Binds to the 23S rRNA
KWO_005260	COG0201	protein transport
KWO_005265	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KWO_005270	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KWO_005275	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KWO_005280	COG0202	RNA polymerase activity
KWO_005285	COG0203	ribosomal protein L17
KWO_005290	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KWO_005305	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KWO_005320	COG0154	amidase activity
KWO_005335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KWO_005345	COG0625	glutathione transferase activity
KWO_005365	COG1902	pentaerythritol trinitrate reductase activity
KWO_005365	COG0446	pyridine nucleotide-disulphide oxidoreductase
KWO_005370	COG0604	alcohol dehydrogenase
KWO_005375	COG2885	chlorophyll binding
KWO_005395	COG0156	8-amino-7-oxononanoate synthase activity
KWO_005400	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KWO_005405	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KWO_005410	COG4208	sulfate ABC transporter
KWO_005415	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KWO_005445	COG0406	alpha-ribazole phosphatase activity
KWO_005455	COG0285	dihydrofolate synthase activity
KWO_005475	COG2833	Protein of unknown function (DUF455)
KWO_005480	COG3291	Pkd domain containing protein
KWO_005490	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KWO_005495	COG0671	phosphoesterase, PA-phosphatase related
KWO_005500	COG0438	transferase activity, transferring glycosyl groups
KWO_005510	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KWO_005525	COG4783	chaperone-mediated protein folding
KWO_005545	COG0473	3-isopropylmalate dehydrogenase activity
KWO_005590	COG0544	peptidyl-prolyl cis-trans isomerase activity
KWO_005595	COG0740	serine-type endopeptidase activity
KWO_005600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KWO_005630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KWO_005645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KWO_005660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KWO_005670	COG0631	protein serine/threonine phosphatase activity
KWO_005690	COG0859	PFAM glycosyl transferase family 9
KWO_005695	COG3642	lipopolysaccharide core region biosynthetic process
KWO_005700	COG1234	tRNA 3'-trailer cleavage
KWO_005705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KWO_005720	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KWO_005725	COG0314	molybdopterin synthase activity
KWO_005780	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KWO_005790	COG0537	adenosine 5'-monophosphoramidase activity
KWO_005810	COG0714	Associated with various cellular activities
KWO_005830	COG1399	metal-binding, possibly nucleic acid-binding protein
KWO_005840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KWO_005855	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_005870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KWO_005875	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KWO_005895	COG4115	mRNA cleavage
KWO_005910	COG3829	transcription factor binding
KWO_005930	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KWO_005995	COG4221	oxidoreductase activity
KWO_006010	COG3039	Transposase
KWO_006065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KWO_006070	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
KWO_006075	COG2080	2 iron, 2 sulfur cluster binding
KWO_006125	COG0587	DNA-directed DNA polymerase activity
KWO_006145	COG1297	OPT oligopeptide transporter protein
KWO_006160	COG1120	ATPase activity
KWO_006175	COG0824	Thioesterase
KWO_006185	COG0848	biopolymer transport protein
KWO_006195	COG0823	Involved in the tonB-independent uptake of proteins
KWO_006200	COG2885	chlorophyll binding
KWO_006210	COG0602	queuosine metabolic process
KWO_006240	COG0840	transmembrane signaling receptor activity
KWO_006260	COG1187	pseudouridine synthase activity
KWO_006295	COG0514	ATP-dependent DNA helicase (RecQ)
KWO_006305	COG0783	Belongs to the Dps family
KWO_006310	COG1643	Atp-dependent helicase
KWO_006325	COG0837	glucose binding
KWO_006355	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
KWO_006360	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KWO_006370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KWO_006380	COG1215	transferase activity, transferring glycosyl groups
KWO_006390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KWO_006400	COG1199	ATP-dependent helicase activity
KWO_006410	COG1397	ADP-ribosylglycohydrolase
KWO_006420	COG0189	ligase activity
KWO_006435	COG0835	chemotaxis
KWO_006440	COG0840	transmembrane signaling receptor activity
KWO_006450	COG2201	protein-glutamate methylesterase activity
KWO_006480	COG1446	asparaginase
KWO_006485	COG3142	Participates in the control of copper homeostasis
KWO_006525	COG3537	Alpha-1,2-mannosidase
KWO_006585	COG1472	Belongs to the glycosyl hydrolase 3 family
KWO_006625	COG1388	LysM domain
KWO_006625	COG3858	chitin binding
KWO_006650	COG0837	glucose binding
KWO_006655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KWO_006665	COG0494	nUDIX hydrolase
KWO_006675	COG3956	TIGRFAM MazG family protein
KWO_006680	COG1742	UPF0060 membrane protein
KWO_006685	COG0330	HflC and HflK could
KWO_006695	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KWO_006700	COG0509	glycine decarboxylation via glycine cleavage system
KWO_006740	COG1960	acyl-CoA dehydrogenase activity
KWO_006745	COG2267	carboxylic ester hydrolase activity
KWO_006750	COG1309	transcriptional regulator
KWO_006765	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KWO_006775	COG0463	Glycosyl transferase, family 2
KWO_006785	COG2982	Protein involved in outer membrane biogenesis
KWO_006790	COG1272	protein, Hemolysin III
KWO_006795	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KWO_006800	COG0739	heme binding
KWO_006805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KWO_006810	COG0626	cystathionine gamma-synthase activity
KWO_006815	COG0527	aspartate kinase activity
KWO_006815	COG0460	homoserine dehydrogenase
KWO_006825	COG1760	l-serine dehydratase
KWO_006855	COG2353	YceI-like domain
KWO_006860	COG2205	protein histidine kinase activity
KWO_006860	COG2198	Histidine kinase
KWO_006860	COG0784	Response regulator, receiver
KWO_006885	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KWO_006900	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KWO_006905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KWO_006910	COG0259	pyridoxamine-phosphate oxidase activity
KWO_006920	COG1842	Phage shock protein A
KWO_006945	COG0754	glutathionylspermidine amidase activity
KWO_006955	COG2814	Major facilitator Superfamily
KWO_006960	COG0789	Transcriptional regulator
KWO_007045	COG0531	amino acid
KWO_007050	COG2197	response regulator
KWO_007065	COG3866	Pectate lyase
KWO_007070	COG1113	amino acid transport
KWO_007080	COG1271	oxidase subunit
KWO_007085	COG1294	oxidase, subunit
KWO_007100	COG2239	Acts as a magnesium transporter
KWO_007110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KWO_007115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWO_007125	COG1660	Displays ATPase and GTPase activities
KWO_007135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWO_007150	COG1137	ATPase activity
KWO_007155	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KWO_007165	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KWO_007175	COG0271	Belongs to the BolA IbaG family
KWO_007180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KWO_007205	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KWO_007215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KWO_007225	COG0628	permease
KWO_007235	COG3293	Transposase
KWO_007245	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KWO_007250	COG3178	'Phosphotransferase
KWO_007260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KWO_007265	COG1555	photosystem II stabilization
KWO_007275	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KWO_007280	COG1477	protein flavinylation
KWO_007305	COG3128	pkhd-type hydroxylase
KWO_007310	COG4774	siderophore transport
KWO_007330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KWO_007335	COG0719	Fe-S assembly protein
KWO_007340	COG0396	ATPase activity
KWO_007345	COG0719	Fe-S assembly protein
KWO_007350	COG1959	2 iron, 2 sulfur cluster binding
KWO_007360	COG0693	protein deglycase activity
KWO_007385	COG4942	peptidase
KWO_007400	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KWO_007425	COG0519	Catalyzes the synthesis of GMP from XMP
KWO_007430	COG1678	Uncharacterized ACR, COG1678
KWO_007435	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KWO_007440	COG0540	Belongs to the ATCase OTCase family
KWO_007455	COG3039	Transposase
KWO_007465	COG1764	response to oxidative stress
KWO_007475	COG0384	phenazine biosynthesis protein PhzF
KWO_007480	COG0384	phenazine biosynthesis protein PhzF
KWO_007485	COG0527	aspartate kinase activity
KWO_007510	COG0142	geranyltranstransferase activity
KWO_007515	COG0629	single-stranded DNA binding
KWO_007520	COG2203	Gaf domain
KWO_007520	COG3706	GGDEF domain
KWO_007520	COG5001	Diguanylate cyclase
KWO_007520	COG4251	negative regulation of phosphorylation
KWO_007525	COG3321	synthase
KWO_007525	COG0604	alcohol dehydrogenase
KWO_007525	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_007530	COG2080	2 iron, 2 sulfur cluster binding
KWO_007535	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
KWO_007540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KWO_007545	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KWO_007575	COG2879	small protein
KWO_007580	COG1966	Carbon starvation protein
KWO_007585	COG1741	Belongs to the pirin family
KWO_007605	COG1741	Belongs to the pirin family
KWO_007610	COG1515	deoxyribonuclease V activity
KWO_007615	COG0588	phosphoglycerate mutase activity
KWO_007635	COG1566	PFAM secretion protein HlyD family protein
KWO_007640	COG1136	(ABC) transporter
KWO_007645	COG1136	(ABC) transporter
KWO_007645	COG0577	efflux transmembrane transporter activity
KWO_007670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KWO_007680	COG0835	chemotaxis
KWO_007685	COG0840	transmembrane signaling receptor activity
KWO_007690	COG2198	Histidine kinase
KWO_007690	COG0643	Histidine kinase
KWO_007700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KWO_007710	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KWO_007715	COG0745	RESPONSE REGULATOR receiver
KWO_007725	COG2205	protein histidine kinase activity
KWO_007735	COG4452	Inner membrane protein CreD
KWO_007760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KWO_007765	COG0735	belongs to the Fur family
KWO_007785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KWO_007825	COG2207	Transcriptional regulator
KWO_007835	COG0583	DNA-binding transcription factor activity
KWO_007840	COG2814	Major facilitator Superfamily
KWO_007845	COG0667	Aldo Keto reductase
KWO_007955	COG5001	Diguanylate cyclase
KWO_007955	COG5002	protein histidine kinase activity
KWO_007960	COG1187	pseudouridine synthase activity
KWO_007965	COG3706	GGDEF domain
KWO_007985	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KWO_007990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KWO_007995	COG0475	glutathione-regulated potassium exporter activity
KWO_008000	COG5000	phosphorelay sensor kinase activity
KWO_008000	COG5002	protein histidine kinase activity
KWO_008005	COG0745	RESPONSE REGULATOR receiver
KWO_008010	COG1538	Outer membrane efflux protein
KWO_008035	COG1132	(ABC) transporter
KWO_008085	COG2155	Conserved Protein
KWO_008100	COG3118	belongs to the thioredoxin family
KWO_008125	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KWO_008145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KWO_008160	COG2968	Membrane
KWO_008170	COG1530	ribonuclease E activity
KWO_008175	COG3164	Protein of unknown function
KWO_008185	COG0312	modulator of DNA gyrase
KWO_008195	COG0312	modulator of DNA gyrase
KWO_008210	COG0142	geranyltranstransferase activity
KWO_008215	COG1722	exodeoxyribonuclease VII activity
KWO_008220	COG0037	tRNA processing
KWO_008225	COG1785	Belongs to the alkaline phosphatase family
KWO_008230	COG1301	dicarboxylic acid transport
KWO_008245	COG0791	NLP P60 protein
KWO_008250	COG0791	NLP P60 protein
KWO_008255	COG1047	Peptidyl-prolyl cis-trans
KWO_008260	COG2311	Membrane
KWO_008265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KWO_008270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KWO_008290	COG3590	peptidase
KWO_008295	COG3590	peptidase
KWO_008325	COG0489	protein tyrosine kinase activity
KWO_008335	COG0717	Belongs to the dCTP deaminase family
KWO_008370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KWO_008380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KWO_008410	COG0433	COG0433 Predicted ATPase
KWO_008420	COG0688	phosphatidylethanolamine metabolic process
KWO_008425	COG0688	phosphatidylethanolamine metabolic process
KWO_008435	COG2890	protein-(glutamine-N5) methyltransferase activity
KWO_008445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KWO_008450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KWO_008470	COG0101	tRNA pseudouridine synthase activity
KWO_008475	COG0135	phosphoribosylanthranilate isomerase activity
KWO_008485	COG0133	tryptophan synthase activity
KWO_008510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KWO_008550	COG3293	Transposase
KWO_008560	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_008565	COG0149	triose-phosphate isomerase activity
KWO_008580	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KWO_008590	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KWO_008600	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KWO_008605	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KWO_008610	COG1034	ATP synthesis coupled electron transport
KWO_008615	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KWO_008620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KWO_008630	COG0713	ATP synthesis coupled electron transport
KWO_008645	COG1007	ATP synthesis coupled electron transport
KWO_008655	COG0779	Required for maturation of 30S ribosomal subunits
KWO_008660	COG0195	Participates in both transcription termination and antitermination
KWO_008665	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KWO_008670	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KWO_008680	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KWO_008715	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KWO_008720	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KWO_008730	COG2095	MarC family integral membrane protein
KWO_008740	COG1611	Belongs to the LOG family
KWO_008745	COG3275	phosphorelay sensor kinase activity
KWO_008795	COG0556	nucleotide-excision repair
KWO_008810	COG3505	Type IV secretory pathway VirD4
KWO_008830	COG2948	multi-organism process
KWO_008850	COG3702	type iv secretory pathway
KWO_008930	COG0504	CTP synthase activity
KWO_008950	COG0148	phosphopyruvate hydratase activity
KWO_008975	COG2840	Smr protein MutS2
KWO_008980	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KWO_008985	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KWO_008990	COG1238	metal cluster binding
KWO_009005	COG1534	Rna-binding protein
KWO_009010	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KWO_009015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KWO_009020	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KWO_009025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KWO_009030	COG1923	regulation of RNA biosynthetic process
KWO_009035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KWO_009040	COG1546	Belongs to the CinA family
KWO_009060	COG2137	regulation of response to DNA damage stimulus
KWO_009070	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KWO_009090	COG1741	Belongs to the pirin family
KWO_009095	COG0583	DNA-binding transcription factor activity
KWO_009120	COG0351	phosphomethylpyrimidine kinase
KWO_009120	COG0352	thiamine-phosphate diphosphorylase activity
KWO_009135	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KWO_009140	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KWO_009155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KWO_009165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KWO_009170	COG3734	2-keto-3-deoxy-galactonokinase
KWO_009180	COG4948	Mandelate Racemase Muconate Lactonizing
KWO_009185	COG0800	Aldolase
KWO_009255	COG1501	Belongs to the glycosyl hydrolase 31 family
KWO_009265	COG1070	Carbohydrate kinase
KWO_009275	COG0477	Major facilitator Superfamily
KWO_009295	COG1469	GTP cyclohydrolase I activity
KWO_009310	COG0617	tRNA 3'-terminal CCA addition
KWO_009320	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KWO_009325	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KWO_009330	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KWO_009355	COG1472	Belongs to the glycosyl hydrolase 3 family
KWO_009385	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KWO_009390	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
KWO_009400	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KWO_009405	COG0671	phosphoesterase, PA-phosphatase related
KWO_009420	COG1794	racemase activity, acting on amino acids and derivatives
KWO_009430	COG0697	spore germination
KWO_009435	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KWO_009455	COG1012	belongs to the aldehyde dehydrogenase family
KWO_009495	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KWO_009505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KWO_009510	COG0124	histidyl-tRNA synthetase
KWO_009520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KWO_009525	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KWO_009530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KWO_009540	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KWO_009545	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KWO_009550	COG0107	imidazoleglycerol-phosphate synthase activity
KWO_009555	COG0140	phosphoribosyl-ATP diphosphatase activity
KWO_009555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KWO_009590	COG0235	Class ii aldolase
KWO_009595	COG0531	amino acid
KWO_009600	COG0531	amino acid
KWO_009610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KWO_009615	COG0277	FAD linked oxidase domain protein
KWO_009635	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KWO_009680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KWO_009685	COG2258	MOSC domain
KWO_009690	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KWO_009695	COG0505	Belongs to the CarA family
KWO_009705	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KWO_009710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KWO_009720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KWO_009750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KWO_009760	COG0784	Response regulator, receiver
KWO_009760	COG2198	Histidine kinase
KWO_009760	COG2205	protein histidine kinase activity
KWO_009770	COG1024	Enoyl-CoA hydratase
KWO_009785	COG3039	Transposase
KWO_009795	COG0318	PFAM AMP-dependent synthetase and ligase
KWO_009825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KWO_009835	COG2201	protein-glutamate methylesterase activity
KWO_009840	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
KWO_009850	COG0840	transmembrane signaling receptor activity
KWO_009860	COG0835	chemotaxis
KWO_009870	COG0840	transmembrane signaling receptor activity
KWO_009875	COG0840	transmembrane signaling receptor activity
KWO_009880	COG0840	transmembrane signaling receptor activity
KWO_009885	COG0840	transmembrane signaling receptor activity
KWO_009890	COG0840	transmembrane signaling receptor activity
KWO_009895	COG0840	transmembrane signaling receptor activity
KWO_009900	COG0840	transmembrane signaling receptor activity
KWO_009905	COG0840	transmembrane signaling receptor activity
KWO_009910	COG0840	transmembrane signaling receptor activity
KWO_009920	COG0840	transmembrane signaling receptor activity
KWO_009940	COG0840	transmembrane signaling receptor activity
KWO_009950	COG0745	RESPONSE REGULATOR receiver
KWO_009960	COG0835	chemotaxis
KWO_009965	COG1192	Involved in chromosome partitioning
KWO_009970	COG1360	Flagellar Motor Protein
KWO_009975	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KWO_010095	COG0643	Histidine kinase
KWO_010095	COG2198	Histidine kinase
KWO_010115	COG0455	bacterial-type flagellum organization
KWO_010150	COG5001	Diguanylate cyclase
KWO_010150	COG3300	MHYT domain
KWO_010155	COG1684	flagellar biosynthetic protein fliR
KWO_010160	COG1987	bacterial-type flagellum assembly
KWO_010175	COG3190	flagellar
KWO_010225	COG1677	Flagellar hook-basal body complex protein FliE
KWO_010255	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_010260	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_010265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KWO_010280	COG2204	response regulator
KWO_010285	COG2201	protein-glutamate methylesterase activity
KWO_010315	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KWO_010320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KWO_010340	COG1706	bacterial-type flagellum-dependent cell motility
KWO_010345	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KWO_010350	COG4786	Flagellar basal body rod
KWO_010360	COG4787	bacterial-type flagellum-dependent cell motility
KWO_010365	COG1749	Flagellar hook protein flgE
KWO_010370	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KWO_010375	COG1558	bacterial-type flagellum-dependent cell motility
KWO_010385	COG0835	chemotaxis
KWO_010385	COG0784	Response regulator, receiver
KWO_010410	COG5002	protein histidine kinase activity
KWO_010420	COG4585	Histidine kinase
KWO_010450	COG0482	sulfurtransferase activity
KWO_010460	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KWO_010465	COG0542	response to heat
KWO_010470	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KWO_010475	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KWO_010485	COG0492	ferredoxin-NADP+ reductase activity
KWO_010490	COG1674	ftsk spoiiie
KWO_010510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KWO_010515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KWO_010520	COG0183	Belongs to the thiolase family
KWO_010525	COG1024	Enoyl-CoA hydratase
KWO_010525	COG1250	3-hydroxyacyl-CoA dehydrogenase
KWO_010535	COG0105	UTP biosynthetic process
KWO_010560	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KWO_010565	COG1160	GTP binding
KWO_010575	COG0303	'Molybdopterin
KWO_010580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KWO_010595	COG2124	cytochrome p450
KWO_010620	COG0708	Exodeoxyribonuclease III
KWO_010625	COG0303	'Molybdopterin
KWO_010630	COG0746	molybdenum cofactor guanylyltransferase activity
KWO_010640	COG1648	precorrin-2 dehydrogenase activity
KWO_010640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KWO_010665	COG3685	Protein conserved in bacteria
KWO_010680	COG5001	Diguanylate cyclase
KWO_010700	COG4566	intracellular signal transduction
KWO_010765	COG2801	Transposase and inactivated derivatives
KWO_010825	COG3501	Rhs element vgr protein
KWO_010860	COG0631	protein serine/threonine phosphatase activity
KWO_010895	COG1858	cytochrome C peroxidase
KWO_011030	COG2154	pterin-4-alpha-carbinolamine dehydratase
KWO_011045	COG0428	transporter
KWO_011050	COG3064	Membrane
KWO_011060	COG1530	ribonuclease E activity
KWO_011095	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KWO_011125	COG0322	excinuclease ABC activity
KWO_011135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KWO_011140	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KWO_011145	COG1663	tetraacyldisaccharide 4'-kinase activity
KWO_011150	COG1132	(ABC) transporter
KWO_011160	COG0811	peptide transport
KWO_011180	COG4591	ABC-type transport system involved in lipoprotein release permease component
KWO_011190	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KWO_011195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KWO_011210	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KWO_011240	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KWO_011245	COG0837	glucose binding
KWO_011250	COG0363	glucosamine-6-phosphate deaminase activity
KWO_011255	COG0129	dihydroxy-acid dehydratase activity
KWO_011260	COG0800	Aldolase
KWO_011335	COG2205	protein histidine kinase activity
KWO_011335	COG0784	Response regulator, receiver
KWO_011345	COG2183	response to ionizing radiation
KWO_011355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KWO_011355	COG0723	plastoquinol--plastocyanin reductase activity
KWO_011370	COG3243	poly(R)-hydroxyalkanoic acid synthase
KWO_011380	COG1183	phosphatidylcholine synthase activity
KWO_011385	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_011400	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KWO_011410	COG0668	transmembrane transport
KWO_011415	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KWO_011420	COG0590	tRNA wobble adenosine to inosine editing
KWO_011425	COG1321	iron dependent repressor
KWO_011430	COG1914	H( )-stimulated, divalent metal cation uptake system
KWO_011445	COG2814	Major facilitator Superfamily
KWO_011475	COG2197	response regulator
KWO_011490	COG0583	DNA-binding transcription factor activity
KWO_011500	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_011515	COG0583	DNA-binding transcription factor activity
KWO_011520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KWO_011540	COG1196	nuclear chromosome segregation
KWO_011545	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KWO_011555	COG1002	Type II restriction enzyme, methylase subunits
KWO_011600	COG1487	ribonuclease activity
KWO_011605	COG4691	Plasmid stability protein
KWO_011635	COG0582	viral genome integration into host DNA
KWO_011655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KWO_011670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KWO_011685	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KWO_011700	COG0539	negative regulation of cytoplasmic translation
KWO_011705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KWO_011710	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KWO_011725	COG2957	Belongs to the agmatine deiminase family
KWO_011735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KWO_011760	COG0395	ABC-type sugar transport system, permease component
KWO_011765	COG1175	transmembrane transport
KWO_011795	COG2350	Protein conserved in bacteria
KWO_011800	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KWO_011805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KWO_011810	COG1187	pseudouridine synthase activity
KWO_011835	COG0436	Aminotransferase
KWO_011840	COG4133	protoheme IX ABC transporter activity
KWO_011860	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KWO_011885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KWO_011890	COG1278	Cold shock
KWO_011900	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KWO_011905	COG4988	ABC transporter
KWO_011965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KWO_011975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KWO_011980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KWO_011990	COG0137	argininosuccinate synthase activity
KWO_011995	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KWO_012010	COG2166	iron-sulfur cluster assembly
KWO_012020	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KWO_012030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KWO_012035	COG0739	heme binding
KWO_012045	COG4302	ethanolamine ammonia-lyase activity
KWO_012080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KWO_012085	COG0402	S-adenosylhomocysteine deaminase activity
KWO_012100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KWO_012105	COG1509	lysine 2,3-aminomutase activity
KWO_012115	COG3300	MHYT domain
KWO_012115	COG5001	Diguanylate cyclase
KWO_012130	COG0483	inositol monophosphate 1-phosphatase activity
KWO_012160	COG0513	Belongs to the DEAD box helicase family
KWO_012170	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KWO_012180	COG0625	glutathione transferase activity
KWO_012195	COG4681	YaeQ
KWO_012210	COG0501	Belongs to the peptidase M48B family
KWO_012220	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_012245	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KWO_012250	COG0860	N-Acetylmuramoyl-L-alanine amidase
KWO_012255	COG0802	atpase or kinase
KWO_012260	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KWO_012260	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KWO_012265	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KWO_012280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KWO_012330	COG0835	chemotaxis
KWO_012335	COG0840	transmembrane signaling receptor activity
KWO_012340	COG2094	Belongs to the DNA glycosylase MPG family
KWO_012345	COG1201	RNA secondary structure unwinding
KWO_012350	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
KWO_012370	COG2969	positive regulation of protein catabolic process
KWO_012375	COG0625	glutathione transferase activity
KWO_012380	COG2857	Cytochrome c1
KWO_012385	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KWO_012390	COG0723	plastoquinol--plastocyanin reductase activity
KWO_012395	COG0741	lytic transglycosylase activity
KWO_012425	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KWO_012440	COG4535	Mg2 and Co2 transporter CorC
KWO_012455	COG1012	belongs to the aldehyde dehydrogenase family
KWO_012460	COG1177	transmembrane transport
KWO_012465	COG1176	ABC-type spermidine putrescine transport system, permease component I
KWO_012475	COG3842	ATPase activity
KWO_012495	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KWO_012515	COG0174	glutamine synthetase
KWO_012520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KWO_012525	COG0745	RESPONSE REGULATOR receiver
KWO_012525	COG3706	GGDEF domain
KWO_012530	COG0477	Major facilitator Superfamily
KWO_012550	COG0243	molybdopterin cofactor binding
KWO_012555	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KWO_012575	COG1121	(ABC) transporter
KWO_012585	COG2733	membrane
KWO_012605	COG0477	Major facilitator Superfamily
KWO_012610	COG2902	Dehydrogenase
KWO_012620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KWO_012625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KWO_012660	COG3039	Transposase
KWO_012675	COG1609	Transcriptional regulator
KWO_012680	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KWO_012680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KWO_012685	COG1105	Belongs to the carbohydrate kinase PfkB family
KWO_012690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KWO_012690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KWO_012730	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KWO_012740	COG1862	Preprotein translocase
KWO_012745	COG0343	queuine tRNA-ribosyltransferase activity
KWO_012750	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KWO_012795	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KWO_012800	COG3291	Pkd domain containing protein
KWO_012815	COG0405	Gamma-glutamyltransferase
KWO_012820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KWO_012835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KWO_012840	COG0742	ribosomal rna small subunit methyltransferase
KWO_012845	COG0326	Molecular chaperone. Has ATPase activity
KWO_012880	COG4206	TonB-dependent receptor
KWO_012950	COG0531	amino acid
KWO_012965	COG0006	proline dipeptidase activity
KWO_012975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KWO_012990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KWO_012995	COG3938	Belongs to the proline racemase family
KWO_013005	COG0552	protein localization to endoplasmic reticulum
KWO_013025	COG0784	Response regulator, receiver
KWO_013025	COG4191	Histidine kinase
KWO_013035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KWO_013060	COG3040	lipid binding
KWO_013070	COG1960	acyl-CoA dehydrogenase activity
KWO_013080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KWO_013100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KWO_013105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KWO_013110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KWO_013145	COG0438	transferase activity, transferring glycosyl groups
KWO_013150	COG0438	transferase activity, transferring glycosyl groups
KWO_013195	COG0776	regulation of translation
KWO_013205	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KWO_013210	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KWO_013215	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KWO_013220	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KWO_013225	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KWO_013235	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KWO_013240	COG0306	phosphate transporter
KWO_013255	COG1253	flavin adenine dinucleotide binding
KWO_013270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KWO_013280	COG0477	Major facilitator Superfamily
KWO_013285	COG1132	(ABC) transporter
KWO_013290	COG1136	(ABC) transporter
KWO_013305	COG0438	transferase activity, transferring glycosyl groups
KWO_013320	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KWO_013345	COG2244	polysaccharide biosynthetic process
KWO_013415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KWO_013425	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KWO_013435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KWO_013450	COG4191	Histidine kinase
KWO_013450	COG0784	Response regulator, receiver
KWO_013455	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KWO_013460	COG5002	protein histidine kinase activity
KWO_013460	COG2205	protein histidine kinase activity
KWO_013460	COG0784	Response regulator, receiver
KWO_013490	COG0840	transmembrane signaling receptor activity
KWO_013530	COG0583	DNA-binding transcription factor activity
KWO_013535	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KWO_013540	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KWO_013555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KWO_013560	COG0077	Prephenate dehydratase
KWO_013560	COG1605	Chorismate mutase
KWO_013565	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KWO_013570	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KWO_013575	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
KWO_013615	COG2986	histidine ammonia-lyase
KWO_013625	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KWO_013650	COG4993	Dehydrogenase
KWO_013660	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KWO_013675	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KWO_013680	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KWO_013685	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KWO_013695	COG3115	cell septum assembly
KWO_013720	COG0316	Belongs to the HesB IscA family
KWO_013730	COG0017	Asparaginyl-tRNA synthetase
KWO_013750	COG2808	Putative FMN-binding domain
KWO_013755	COG0288	reversible hydration of carbon dioxide
KWO_013770	COG3844	kynureninase activity
KWO_013775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KWO_013780	COG2925	Exonuclease
KWO_013790	COG0667	Aldo Keto reductase
KWO_013810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KWO_013815	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KWO_013815	COG0116	Belongs to the methyltransferase superfamily
KWO_013860	COG0494	nUDIX hydrolase
KWO_013870	COG1024	Enoyl-CoA hydratase
KWO_013880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KWO_013890	COG0659	secondary active sulfate transmembrane transporter activity
KWO_013920	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KWO_013925	COG0573	inorganic phosphate transmembrane transporter activity
KWO_013930	COG0581	inorganic phosphate transmembrane transporter activity
KWO_013935	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KWO_013940	COG0704	Plays a role in the regulation of phosphate uptake
KWO_013950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KWO_013955	COG3706	GGDEF domain
KWO_013960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KWO_013970	COG0557	exoribonuclease II activity
KWO_013985	COG1960	acyl-CoA dehydrogenase activity
KWO_013995	COG0646	methionine synthase
KWO_013995	COG1410	methionine synthase
KWO_014010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KWO_014050	COG0386	Belongs to the glutathione peroxidase family
KWO_014060	COG1725	Transcriptional regulator
KWO_014065	COG1131	(ABC) transporter
KWO_014095	COG1253	flavin adenine dinucleotide binding
KWO_014130	COG2850	peptidyl-arginine hydroxylation
KWO_014165	COG1132	(ABC) transporter
KWO_014175	COG0583	DNA-binding transcription factor activity
KWO_014210	COG0484	heat shock protein binding
KWO_014215	COG0443	Heat shock 70 kDa protein
KWO_014220	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KWO_014225	COG1420	regulation of RNA biosynthetic process
KWO_014230	COG0497	DNA recombination
KWO_014240	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KWO_014250	COG2914	Belongs to the UPF0125 (RnfH) family
KWO_014260	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KWO_014295	COG3706	GGDEF domain
KWO_014305	COG3706	GGDEF domain
KWO_014340	COG0583	DNA-binding transcription factor activity
KWO_014355	COG0415	Belongs to the DNA photolyase family
KWO_014360	COG0305	Participates in initiation and elongation during chromosome replication
KWO_014370	COG0367	asparagine synthase
KWO_014390	COG1960	acyl-CoA dehydrogenase activity
KWO_014410	COG0084	hydrolase, TatD family'
KWO_014415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KWO_014475	COG0386	Belongs to the glutathione peroxidase family
KWO_014485	COG0339	signal peptide processing
KWO_014560	COG2814	Major facilitator Superfamily
KWO_014565	COG1566	PFAM secretion protein HlyD family protein
KWO_014580	COG2207	Transcriptional regulator
KWO_014595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KWO_014615	COG4774	siderophore transport
KWO_014625	COG0367	asparagine synthase
KWO_014630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KWO_014640	COG1393	Belongs to the ArsC family
KWO_014655	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KWO_014660	COG0024	Methionine aminopeptidase
KWO_014700	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KWO_014705	COG3706	GGDEF domain
KWO_014710	COG0528	UMP kinase activity
KWO_014730	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KWO_014735	COG0750	zinc metalloprotease
KWO_014750	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KWO_014755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KWO_014760	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KWO_014765	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KWO_014770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KWO_014785	COG0825	malonyl-CoA metabolic process
KWO_014845	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KWO_014855	COG2040	homocysteine
KWO_014860	COG0833	amino acid
KWO_014865	COG0346	lactoylglutathione lyase activity
KWO_014875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KWO_014875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KWO_014885	COG2878	Part of a membrane complex involved in electron transport
KWO_014905	COG1595	DNA-templated transcription, initiation
KWO_014930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KWO_014945	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KWO_014950	COG0251	oxidation-reduction process
KWO_014960	COG0392	lysyltransferase activity
KWO_014960	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KWO_014995	COG2814	Major facilitator Superfamily
KWO_015000	COG1902	pentaerythritol trinitrate reductase activity
KWO_015015	COG2824	Alkylphosphonate utilization operon protein PhnA
KWO_015030	COG1047	Peptidyl-prolyl cis-trans
KWO_015065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KWO_015075	COG5487	UPF0391 membrane protein
KWO_015085	COG1451	nucleotide metabolic process
KWO_015105	COG0183	Belongs to the thiolase family
KWO_015120	COG5001	Diguanylate cyclase
KWO_015135	COG1793	dna ligase
KWO_015135	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KWO_015145	COG1793	dna ligase
KWO_015165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KWO_015170	COG1278	Cold shock
KWO_015175	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KWO_015185	COG1472	Belongs to the glycosyl hydrolase 3 family
KWO_015190	COG3046	protein related to deoxyribodipyrimidine photolyase
KWO_015195	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
KWO_015200	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KWO_015225	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KWO_015230	COG0571	ribonuclease III activity
KWO_015250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KWO_015265	COG1250	3-hydroxyacyl-CoA dehydrogenase
KWO_015265	COG1024	Enoyl-CoA hydratase
KWO_015290	COG1024	Enoyl-CoA hydratase
KWO_015295	COG1960	acyl-CoA dehydrogenase activity
KWO_015315	COG3867	Arabinogalactan endo-beta-1,4-galactanase
KWO_015320	COG3250	beta-galactosidase activity
KWO_015335	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KWO_015350	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_015355	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_015360	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_015370	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KWO_015380	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KWO_015390	COG0534	Mate efflux family protein
KWO_015400	COG0336	Belongs to the RNA methyltransferase TrmD family
KWO_015405	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KWO_015410	COG0228	four-way junction DNA binding
KWO_015415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KWO_015420	COG2070	2-Nitropropane dioxygenase
KWO_015430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KWO_015435	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KWO_015455	COG0784	Response regulator, receiver
KWO_015455	COG4191	Histidine kinase
KWO_015460	COG2205	protein histidine kinase activity
KWO_015460	COG3437	response regulator, receiver
KWO_015460	COG4999	Histidine kinase
KWO_015460	COG3850	Histidine kinase
KWO_015465	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KWO_015475	COG2205	protein histidine kinase activity
KWO_015480	COG5507	3-demethylubiquinone-9 3-methyltransferase
KWO_015515	COG2172	sigma factor antagonist activity
KWO_015520	COG1366	Belongs to the anti-sigma-factor antagonist family
KWO_015525	COG1366	Belongs to the anti-sigma-factor antagonist family
KWO_015535	COG0326	Molecular chaperone. Has ATPase activity
KWO_015540	COG2207	Transcriptional regulator
KWO_015555	COG3152	Membrane
KWO_015570	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KWO_015575	COG1845	cytochrome c oxidase, subunit III
KWO_015580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KWO_015595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KWO_015600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KWO_015605	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KWO_015610	COG0196	riboflavin kinase activity
KWO_015615	COG0728	peptidoglycan biosynthetic process
KWO_015620	COG0268	Binds directly to 16S ribosomal RNA
KWO_015635	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KWO_015640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KWO_015645	COG0824	Thioesterase
KWO_015660	COG1946	Acyl-CoA thioesterase
KWO_015690	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
KWO_015705	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
KWO_015735	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KWO_015750	COG2197	response regulator
KWO_015755	COG4585	Histidine kinase
KWO_015770	COG0850	regulation of cytokinetic process
KWO_015775	COG2894	cell division
KWO_015780	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KWO_015790	COG0642	Histidine kinase
KWO_015795	COG0745	RESPONSE REGULATOR receiver
KWO_015810	COG2194	sulfuric ester hydrolase activity
KWO_015825	COG2814	Major facilitator Superfamily
KWO_015850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KWO_015850	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KWO_015860	COG0656	L-ascorbic acid biosynthetic process
KWO_015865	COG0753	catalase activity
KWO_015940	COG1917	Cupin 2, conserved barrel domain protein
KWO_015940	COG2207	Transcriptional regulator
KWO_015950	COG0823	Involved in the tonB-independent uptake of proteins
KWO_015950	COG1506	peptidase
KWO_016000	COG0477	Major facilitator Superfamily
KWO_016020	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KWO_016040	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KWO_016050	COG3158	transport of potassium into the cell
KWO_016080	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KWO_016085	COG0328	RNA-DNA hybrid ribonuclease activity
KWO_016085	COG0406	alpha-ribazole phosphatase activity
KWO_016125	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
KWO_016170	COG0308	aminopeptidase N
KWO_016180	COG0330	HflC and HflK could
KWO_016185	COG0330	HflC and HflK could
KWO_016205	COG0678	peroxiredoxin activity
KWO_016215	COG4953	penicillin-binding protein 1C
KWO_016235	COG2373	Large extracellular alpha-helical protein
KWO_016290	COG0488	(ABC) transporter
KWO_016330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KWO_016330	COG4651	solute:proton antiporter activity
KWO_016340	COG4772	TonB-dependent receptor
KWO_016350	COG4264	IucA IucC family
KWO_016355	COG2814	Major facilitator Superfamily
KWO_016365	COG0019	diaminopimelate decarboxylase activity
KWO_016405	COG0542	response to heat
KWO_016410	COG1116	anion transmembrane transporter activity
KWO_016415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KWO_016420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KWO_016425	COG0667	Aldo Keto reductase
KWO_016435	COG4771	TonB-dependent receptor
KWO_016440	COG2827	Endonuclease containing a URI domain
KWO_016490	COG1877	trehalose-phosphatase activity
KWO_016495	COG3387	PFAM Glycoside hydrolase 15-related
KWO_016510	COG0840	transmembrane signaling receptor activity
KWO_016515	COG3011	Protein conserved in bacteria
KWO_016530	COG0564	pseudouridine synthase activity
KWO_016535	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KWO_016540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KWO_016540	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KWO_016555	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KWO_016560	COG0045	succinate-CoA ligase (ADP-forming) activity
KWO_016595	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KWO_016600	COG0237	dephospho-CoA kinase activity
KWO_016640	COG0745	RESPONSE REGULATOR receiver
KWO_016700	COG0519	Catalyzes the synthesis of GMP from XMP
KWO_016700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KWO_016710	COG0805	protein transport
KWO_016715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KWO_016720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KWO_016730	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KWO_016750	COG2974	May be involved in recombination
KWO_016755	COG0037	tRNA processing
KWO_016775	COG3661	Belongs to the glycosyl hydrolase 67 family
KWO_016785	COG4948	Mandelate Racemase Muconate Lactonizing
KWO_016795	COG1472	Belongs to the glycosyl hydrolase 3 family
KWO_016800	COG0246	Mannitol dehydrogenase
KWO_016870	COG3386	PFAM SMP-30 Gluconolaconase
KWO_016910	COG1904	glucuronate isomerase
KWO_016915	COG3693	PFAM glycoside hydrolase, family 10
KWO_016935	COG2211	Major facilitator Superfamily
KWO_016975	COG2937	Belongs to the GPAT DAPAT family
KWO_017005	COG0284	orotidine-5'-phosphate decarboxylase activity
KWO_017010	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
KWO_017030	COG0210	DNA helicase
KWO_017035	COG1435	thymidine kinase activity
KWO_017045	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
KWO_017055	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KWO_017090	COG0739	heme binding
KWO_017105	COG2211	Major facilitator Superfamily
KWO_017110	COG0708	Exodeoxyribonuclease III
KWO_017125	COG1192	Involved in chromosome partitioning
KWO_017130	COG1475	DNA binding
KWO_017150	COG0463	Glycosyl transferase, family 2
KWO_017175	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KWO_017185	COG0018	arginyl-trna synthetase
KWO_017200	COG4221	oxidoreductase activity
KWO_017215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KWO_017220	COG1166	arginine decarboxylase activity
KWO_017225	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KWO_017255	COG3291	Pkd domain containing protein
KWO_017255	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KWO_017270	COG0606	chelatase, subunit chli
KWO_017285	COG4943	cyclic-guanylate-specific phosphodiesterase activity
KWO_017320	COG1690	Belongs to the RtcB family
KWO_017355	COG1090	epimerase
KWO_017365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KWO_017385	COG0628	permease
KWO_017390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KWO_017395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KWO_017405	COG1595	DNA-templated transcription, initiation
KWO_017410	COG0753	catalase activity
KWO_017425	COG2197	response regulator
KWO_017430	COG4585	Histidine kinase
KWO_017435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KWO_017440	COG1136	(ABC) transporter
KWO_017465	COG0697	spore germination
KWO_017490	COG0180	Tryptophanyl-tRNA synthetase
KWO_017495	COG3237	CsbD-like
KWO_017540	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KWO_017560	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KWO_017560	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KWO_017575	COG3228	Belongs to the MtfA family
KWO_017590	COG2205	protein histidine kinase activity
KWO_017595	COG0745	RESPONSE REGULATOR receiver
KWO_017605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KWO_017640	COG1199	ATP-dependent helicase activity
KWO_017655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KWO_017670	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KWO_017735	COG0625	glutathione transferase activity
KWO_017770	COG4555	ABC transporter
KWO_017785	COG1476	TRANSCRIPTIONal
KWO_017805	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KWO_017810	COG1131	(ABC) transporter
KWO_017815	COG0842	Transport permease protein
KWO_017825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KWO_017860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KWO_017875	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KWO_017885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KWO_017900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KWO_017900	COG1042	CoA-binding domain protein
KWO_017900	COG0045	succinate-CoA ligase (ADP-forming) activity
KWO_017910	COG2239	Acts as a magnesium transporter
KWO_017925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KWO_017930	COG3387	PFAM Glycoside hydrolase 15-related
KWO_017945	COG3100	YcgL domain-containing protein
KWO_017950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KWO_017960	COG0463	Glycosyl transferase, family 2
KWO_017975	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_018000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KWO_018015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KWO_018080	COG1121	(ABC) transporter
KWO_018095	COG3220	belongs to the UPF0276 family
KWO_018230	COG0210	DNA helicase
KWO_018245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KWO_018255	COG2159	amidohydrolase
KWO_018265	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KWO_018270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KWO_018280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KWO_018305	COG0357	Ribosomal RNA small subunit methyltransferase G
KWO_018320	COG2091	lysine biosynthetic process via aminoadipic acid
KWO_018335	COG0708	Exodeoxyribonuclease III
KWO_018340	COG1940	carbohydrate kinase activity
KWO_018350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KWO_018360	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KWO_018365	COG3162	membrane
KWO_018425	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_018430	COG0179	Fumarylacetoacetate (FAA) hydrolase
KWO_018435	COG4948	Mandelate Racemase Muconate Lactonizing
KWO_018440	COG3254	rhamnose metabolic process
KWO_018445	COG0738	Major facilitator superfamily
KWO_018450	COG1414	Transcriptional regulator
KWO_018465	COG2205	protein histidine kinase activity
KWO_018475	COG3459	Glycosyltransferase 36 associated
KWO_018480	COG2211	Major facilitator Superfamily
KWO_018485	COG3265	gluconokinase activity
KWO_018525	COG2911	Protein conserved in bacteria
KWO_018530	COG0729	surface antigen
KWO_018545	COG3293	Transposase
KWO_018555	COG4771	TonB-dependent receptor
KWO_018560	COG0457	Tetratricopeptide repeat
KWO_018570	COG0752	glycyl-tRNA synthetase alpha subunit
KWO_018575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KWO_018610	COG2022	thiamine diphosphate biosynthetic process
KWO_018615	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KWO_018620	COG3273	potassium ion transport
KWO_018620	COG0471	metal ion transport
KWO_018640	COG1970	mechanosensitive ion channel activity
KWO_018650	COG1609	Transcriptional regulator
KWO_018675	COG3250	beta-galactosidase activity
KWO_018680	COG4948	Mandelate Racemase Muconate Lactonizing
KWO_018700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KWO_018715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KWO_018725	COG0529	Catalyzes the synthesis of activated sulfate
KWO_018725	COG2895	sulfate adenylyltransferase (ATP) activity
KWO_018735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KWO_018740	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KWO_018765	COG2205	protein histidine kinase activity
KWO_018765	COG2198	Histidine kinase
KWO_018765	COG0784	Response regulator, receiver
KWO_018780	COG0583	DNA-binding transcription factor activity
KWO_018800	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KWO_018805	COG3588	fructose-bisphosphate aldolase
KWO_018815	COG0469	pyruvate kinase activity
KWO_018850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KWO_018870	COG3047	cAMP biosynthetic process
KWO_018880	COG3453	Protein conserved in bacteria
KWO_018880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KWO_018885	COG0725	ABC transporter, periplasmic molybdate-binding protein
KWO_018890	COG4149	molybdate abc transporter
KWO_018915	COG1376	ErfK ybiS ycfS ynhG family protein
KWO_018920	COG0739	heme binding
KWO_018925	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_018930	COG0583	DNA-binding transcription factor activity
KWO_018945	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KWO_018950	COG1301	dicarboxylic acid transport
KWO_018965	COG2304	oxidoreductase activity
KWO_018985	COG0714	Associated with various cellular activities
KWO_019015	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KWO_019030	COG0254	rRNA binding
KWO_019040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KWO_019050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KWO_019055	COG1758	RNA polymerase activity
KWO_019065	COG1561	YicC-like family, N-terminal region
KWO_019070	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KWO_019085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KWO_019100	COG0006	proline dipeptidase activity
KWO_019110	COG0006	proline dipeptidase activity
KWO_019135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KWO_019155	COG2912	Transglutaminase-like superfamily
KWO_019160	COG1773	rubredoxin
KWO_019165	COG0352	thiamine-phosphate diphosphorylase activity
KWO_019180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KWO_019190	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
KWO_019195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KWO_019225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KWO_019230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KWO_019240	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_019250	COG0671	phosphoesterase, PA-phosphatase related
KWO_019255	COG3781	membrane
KWO_019265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KWO_019285	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KWO_019295	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KWO_019315	COG3710	Transcriptional regulator
KWO_019335	COG0840	transmembrane signaling receptor activity
KWO_019365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KWO_019370	COG0473	3-isopropylmalate dehydrogenase activity
KWO_019375	COG2226	methyltransferase
KWO_019380	COG0066	3-isopropylmalate dehydratase activity
KWO_019385	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KWO_019415	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KWO_019420	COG1538	Outer membrane efflux protein
KWO_019425	COG1519	Transferase
KWO_019430	COG1560	Kdo2-lipid A biosynthetic process
KWO_019525	COG0280	phosphate acetyltransferase
KWO_019525	COG0281	malic enzyme
KWO_019530	COG1301	dicarboxylic acid transport
KWO_019540	COG4191	Histidine kinase
KWO_019555	COG0583	DNA-binding transcription factor activity
KWO_019560	COG0667	Aldo Keto reductase
KWO_019575	COG2197	response regulator
KWO_019585	COG0642	Histidine kinase
KWO_019610	COG2851	Citrate transporter
KWO_019615	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_019620	COG1609	Transcriptional regulator
KWO_019630	COG2211	Major facilitator Superfamily
KWO_019655	COG1162	GTPase activity
KWO_019660	COG0436	Aminotransferase
KWO_019680	COG0726	polysaccharide deacetylase
KWO_019685	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KWO_019700	COG3964	amidohydrolase
KWO_019760	COG3791	Glutathione-dependent formaldehyde-activating
KWO_019780	COG0745	RESPONSE REGULATOR receiver
KWO_019785	COG2205	protein histidine kinase activity
KWO_019810	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KWO_019825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KWO_019845	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
KWO_019850	COG0456	acetyltransferase
KWO_019860	COG1183	phosphatidylcholine synthase activity
KWO_019870	COG0442	prolyl-tRNA aminoacylation
KWO_019885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KWO_019890	COG1127	ABC transporter
KWO_019895	COG3218	ABC-type transport auxiliary lipoprotein component
KWO_019895	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KWO_019935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KWO_019940	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
KWO_019940	COG0662	Cupin 2, conserved barrel domain protein
KWO_019965	COG2086	electron transfer activity
KWO_019980	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KWO_019980	COG0546	phosphoglycolate phosphatase activity
KWO_019985	COG0277	FAD linked oxidase domain protein
KWO_020000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KWO_020030	COG0438	transferase activity, transferring glycosyl groups
KWO_020030	COG1216	Glycosyl transferase, family 2
KWO_020050	COG0626	cystathionine gamma-synthase activity
KWO_020080	COG0625	glutathione transferase activity
KWO_020095	COG0513	Belongs to the DEAD box helicase family
KWO_020105	COG0720	synthase
KWO_020115	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KWO_020120	COG1956	GAF domain-containing protein
KWO_020130	COG0546	phosphoglycolate phosphatase activity
KWO_020135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KWO_020160	COG0339	signal peptide processing
KWO_020210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KWO_020215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KWO_020220	COG1136	(ABC) transporter
KWO_020225	COG0577	efflux transmembrane transporter activity
KWO_020230	COG0577	efflux transmembrane transporter activity
KWO_020235	COG2204	response regulator
KWO_020245	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KWO_020280	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KWO_020285	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KWO_020290	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KWO_020305	COG0356	it plays a direct role in the translocation of protons across the membrane
KWO_020325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KWO_020335	COG0508	dehydrogenase complex catalyzes the overall conversion of
KWO_020380	COG2011	ABC-type metal ion transport system permease component
KWO_020385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KWO_020390	COG0697	spore germination
KWO_020395	COG1666	GTP binding
KWO_020405	COG0784	Response regulator, receiver
KWO_020405	COG5002	protein histidine kinase activity
KWO_020405	COG2198	Histidine kinase
KWO_020425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KWO_020430	COG1187	pseudouridine synthase activity
KWO_020435	COG2813	Specifically methylates the guanine in position
KWO_020465	COG2205	protein histidine kinase activity
KWO_020465	COG2202	Pas domain
KWO_020485	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KWO_020490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KWO_020495	COG1522	sequence-specific DNA binding
KWO_020535	COG0745	RESPONSE REGULATOR receiver
KWO_020550	COG1404	Belongs to the peptidase S8 family
KWO_020575	COG0842	Transport permease protein
KWO_020580	COG1131	(ABC) transporter
KWO_020585	COG0025	NhaP-type Na H and K H
KWO_020595	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
KWO_020600	COG1573	uracil-dna glycosylase
KWO_020615	COG3384	dioxygenase
KWO_020625	COG0583	DNA-binding transcription factor activity
KWO_020635	COG0667	Aldo Keto reductase
KWO_020645	COG3590	peptidase
KWO_020660	COG0531	amino acid
KWO_020675	COG2972	Histidine kinase
KWO_020700	COG3685	Protein conserved in bacteria
KWO_020705	COG3546	catalase activity
KWO_020750	COG1271	oxidase subunit
KWO_020755	COG1294	oxidase, subunit
KWO_020770	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_020780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KWO_020800	COG1132	(ABC) transporter
KWO_020815	COG1063	alcohol dehydrogenase
KWO_020900	COG0038	chloride channel
KWO_020910	COG0024	Methionine aminopeptidase
KWO_020940	COG3179	chitinase
KWO_021020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KWO_021025	COG1490	D-aminoacyl-tRNA deacylase activity
KWO_021030	COG1560	Kdo2-lipid A biosynthetic process
KWO_021075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KWO_021075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KWO_021080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KWO_021085	COG0242	peptide deformylase activity
KWO_021090	COG1652	LysM domain
KWO_021095	COG0758	DNA mediated transformation
KWO_021115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KWO_021115	COG1754	DNA topoisomerase type I activity
KWO_021120	COG0009	L-threonylcarbamoyladenylate synthase
KWO_021135	COG1028	Short-chain dehydrogenase reductase Sdr
KWO_021145	COG0616	signal peptide processing
KWO_021150	COG0534	Mate efflux family protein
KWO_021175	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KWO_021180	COG0625	glutathione transferase activity
KWO_021195	COG1252	NADH dehydrogenase
KWO_021200	COG2860	membrane
KWO_021205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KWO_021215	COG3437	response regulator, receiver
KWO_021220	COG2177	Part of the ABC transporter FtsEX involved in
KWO_021225	COG2884	Cell division ATP-binding protein ftsE
KWO_021235	COG3118	belongs to the thioredoxin family
KWO_021240	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KWO_021250	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
KWO_021300	COG1518	maintenance of DNA repeat elements
KWO_021305	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KWO_021315	COG1652	LysM domain
KWO_021320	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KWO_021320	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KWO_021335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KWO_021360	COG5383	Protein conserved in bacteria
KWO_021400	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
KWO_021405	COG3023	N-Acetylmuramoyl-L-alanine amidase
KWO_021415	COG4948	Mandelate Racemase Muconate Lactonizing
KWO_021425	COG0531	amino acid
KWO_021440	COG4682	membrane
KWO_021445	COG2133	pyrroloquinoline quinone binding
KWO_021455	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KWO_021465	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KWO_021470	COG1610	YqeY-like protein
KWO_021475	COG1295	ribonuclease BN
KWO_021480	COG0358	DNA primase activity
KWO_021495	COG0109	protoheme IX farnesyltransferase activity
KWO_021525	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
KWO_021540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KWO_021610	COG0676	glucose-6-phosphate 1-epimerase activity
KWO_021620	COG3012	SEC-C Motif Domain Protein
KWO_021625	COG0730	response to heat
KWO_021655	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KWO_021660	COG0302	gtp cyclohydrolase
KWO_021675	COG1566	PFAM secretion protein HlyD family protein
KWO_021685	COG1289	transmembrane transporter activity
KWO_021690	COG0477	Major facilitator Superfamily
KWO_021700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KWO_021750	COG0564	pseudouridine synthase activity
KWO_021770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KWO_021820	COG3549	Plasmid maintenance system killer
KWO_021825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KWO_021830	COG1074	ATP-dependent DNA helicase activity
KWO_021835	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KWO_021870	COG1127	ABC transporter
KWO_021875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KWO_021880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KWO_021895	COG2853	Lipoprotein
KWO_021905	COG0386	Belongs to the glutathione peroxidase family
KWO_021915	COG1322	Protein conserved in bacteria
KWO_021920	COG0604	alcohol dehydrogenase
KWO_021925	COG0583	DNA-binding transcription factor activity
KWO_021950	COG0531	amino acid
KWO_021975	COG2203	Gaf domain
KWO_021975	COG2199	diguanylate cyclase activity
KWO_021980	COG3835	regulator
KWO_021985	COG1929	Belongs to the glycerate kinase type-1 family
KWO_021990	COG2271	Major facilitator Superfamily
KWO_022010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KWO_022020	COG0861	Integral membrane protein TerC family
KWO_022030	COG0584	glycerophosphoryl diester phosphodiesterase
KWO_022045	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KWO_022055	COG0706	membrane insertase activity
KWO_022065	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KWO_022090	COG3451	type IV secretory pathway VirB4
KWO_022105	COG3846	protein secretion by the type IV secretion system
KWO_022140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KWO_022270	COG0489	protein tyrosine kinase activity
KWO_022335	COG4962	Type ii secretion system protein e
KWO_022350	COG3451	type IV secretory pathway VirB4
KWO_022365	COG3846	protein secretion by the type IV secretion system