locus-tag	class	description
BHE83_00005	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BHE83_00010	COG0575	Belongs to the CDS family
BHE83_00015	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BHE83_00020	COG0233	cytoplasmic translational termination
BHE83_00025	COG0528	UMP kinase activity
BHE83_00030	COG0745	RESPONSE REGULATOR receiver
BHE83_00030	COG3706	GGDEF domain
BHE83_00035	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BHE83_00040	COG0052	Belongs to the universal ribosomal protein uS2 family
BHE83_00075	COG0024	Methionine aminopeptidase
BHE83_00080	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BHE83_00090	COG1393	Belongs to the ArsC family
BHE83_00095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BHE83_00100	COG0367	asparagine synthase
BHE83_00125	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BHE83_00150	COG1566	PFAM secretion protein HlyD family protein
BHE83_00155	COG2814	Major facilitator Superfamily
BHE83_00215	COG0339	signal peptide processing
BHE83_00220	COG0386	Belongs to the glutathione peroxidase family
BHE83_00280	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BHE83_00285	COG0084	hydrolase, TatD family'
BHE83_00300	COG1960	acyl-CoA dehydrogenase activity
BHE83_00315	COG0367	asparagine synthase
BHE83_00325	COG0305	Participates in initiation and elongation during chromosome replication
BHE83_00330	COG0415	Belongs to the DNA photolyase family
BHE83_00340	COG0583	DNA-binding transcription factor activity
BHE83_00375	COG3706	GGDEF domain
BHE83_00385	COG3706	GGDEF domain
BHE83_00400	COG2963	transposase activity
BHE83_00425	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BHE83_00440	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BHE83_00450	COG0497	DNA recombination
BHE83_00455	COG1420	regulation of RNA biosynthetic process
BHE83_00460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BHE83_00465	COG0443	Heat shock 70 kDa protein
BHE83_00470	COG0484	heat shock protein binding
BHE83_00475	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BHE83_00505	COG0583	DNA-binding transcription factor activity
BHE83_00510	COG1132	(ABC) transporter
BHE83_00545	COG2850	peptidyl-arginine hydroxylation
BHE83_00565	COG1253	flavin adenine dinucleotide binding
BHE83_00595	COG1131	(ABC) transporter
BHE83_00600	COG1725	Transcriptional regulator
BHE83_00605	COG0386	Belongs to the glutathione peroxidase family
BHE83_00620	COG2900	Belongs to the SlyX family
BHE83_00645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BHE83_00655	COG0646	methionine synthase
BHE83_00655	COG1410	methionine synthase
BHE83_00660	COG0646	methionine synthase
BHE83_00660	COG1410	methionine synthase
BHE83_00670	COG1960	acyl-CoA dehydrogenase activity
BHE83_00690	COG0557	exoribonuclease II activity
BHE83_00705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BHE83_00715	COG3706	GGDEF domain
BHE83_00720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BHE83_00730	COG0704	Plays a role in the regulation of phosphate uptake
BHE83_00735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BHE83_00740	COG0581	inorganic phosphate transmembrane transporter activity
BHE83_00745	COG0573	inorganic phosphate transmembrane transporter activity
BHE83_00750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BHE83_00775	COG0659	secondary active sulfate transmembrane transporter activity
BHE83_00780	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BHE83_00790	COG1024	Enoyl-CoA hydratase
BHE83_00800	COG0494	nUDIX hydrolase
BHE83_00845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BHE83_00845	COG0116	Belongs to the methyltransferase superfamily
BHE83_00850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BHE83_00870	COG2925	Exonuclease
BHE83_00880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BHE83_00885	COG3844	kynureninase activity
BHE83_00895	COG0662	Cupin 2, conserved barrel domain protein
BHE83_00900	COG0288	reversible hydration of carbon dioxide
BHE83_00955	COG2808	Putative FMN-binding domain
BHE83_00975	COG0017	Asparaginyl-tRNA synthetase
BHE83_00980	COG0316	Belongs to the HesB IscA family
BHE83_00985	COG0360	Binds together with S18 to 16S ribosomal RNA
BHE83_00990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BHE83_00995	COG0359	binds to the 23S rRNA
BHE83_01005	COG3115	cell septum assembly
BHE83_01015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BHE83_01020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BHE83_01025	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BHE83_01040	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BHE83_01050	COG4993	Dehydrogenase
BHE83_01060	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BHE83_01070	COG2986	histidine ammonia-lyase
BHE83_01075	COG1228	amidohydrolase
BHE83_01115	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BHE83_01120	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BHE83_01125	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BHE83_01130	COG1605	Chorismate mutase
BHE83_01130	COG0077	Prephenate dehydratase
BHE83_01135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BHE83_01150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BHE83_01155	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BHE83_01160	COG0583	DNA-binding transcription factor activity
BHE83_01180	COG2801	Transposase and inactivated derivatives
BHE83_01195	COG0840	transmembrane signaling receptor activity
BHE83_01225	COG0784	Response regulator, receiver
BHE83_01225	COG2205	protein histidine kinase activity
BHE83_01225	COG5002	protein histidine kinase activity
BHE83_01230	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BHE83_01235	COG0784	Response regulator, receiver
BHE83_01235	COG4191	Histidine kinase
BHE83_01250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BHE83_01260	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BHE83_01270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BHE83_01285	COG1595	DNA-templated transcription, initiation
BHE83_01325	COG2244	polysaccharide biosynthetic process
BHE83_01355	COG2264	protein methyltransferase activity
BHE83_01365	COG0438	transferase activity, transferring glycosyl groups
BHE83_01385	COG1136	(ABC) transporter
BHE83_01390	COG1132	(ABC) transporter
BHE83_01400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BHE83_01415	COG1253	flavin adenine dinucleotide binding
BHE83_01425	COG0306	phosphate transporter
BHE83_01450	COG0504	CTP synthase activity
BHE83_01455	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BHE83_01465	COG0148	phosphopyruvate hydratase activity
BHE83_01470	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BHE83_01475	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BHE83_01480	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BHE83_01485	COG0585	pseudouridine synthase activity
BHE83_01490	COG2840	Smr protein MutS2
BHE83_01495	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BHE83_01500	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BHE83_01505	COG1238	metal cluster binding
BHE83_01520	COG1534	Rna-binding protein
BHE83_01525	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BHE83_01530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BHE83_01535	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BHE83_01540	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BHE83_01545	COG1923	regulation of RNA biosynthetic process
BHE83_01550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BHE83_01555	COG1546	Belongs to the CinA family
BHE83_01565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BHE83_01570	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BHE83_01575	COG2137	regulation of response to DNA damage stimulus
BHE83_01580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BHE83_01585	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BHE83_01600	COG1741	Belongs to the pirin family
BHE83_01610	COG0583	DNA-binding transcription factor activity
BHE83_01635	COG0351	phosphomethylpyrimidine kinase
BHE83_01650	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BHE83_01655	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BHE83_01670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BHE83_01680	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BHE83_01685	COG3734	2-keto-3-deoxy-galactonokinase
BHE83_01695	COG4948	Mandelate Racemase Muconate Lactonizing
BHE83_01700	COG0800	Aldolase
BHE83_01740	COG1501	Belongs to the glycosyl hydrolase 31 family
BHE83_01750	COG1070	Carbohydrate kinase
BHE83_01755	COG2115	Belongs to the xylose isomerase family
BHE83_01760	COG0477	Major facilitator Superfamily
BHE83_01775	COG0860	N-Acetylmuramoyl-L-alanine amidase
BHE83_01780	COG1469	GTP cyclohydrolase I activity
BHE83_01800	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BHE83_01805	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BHE83_01810	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BHE83_01815	COG0166	Belongs to the GPI family
BHE83_01835	COG1472	Belongs to the glycosyl hydrolase 3 family
BHE83_01845	COG4251	negative regulation of phosphorylation
BHE83_01845	COG2203	Gaf domain
BHE83_01845	COG5001	Diguanylate cyclase
BHE83_01845	COG3706	GGDEF domain
BHE83_01850	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BHE83_01855	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BHE83_01865	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BHE83_01870	COG0671	phosphoesterase, PA-phosphatase related
BHE83_01880	COG1794	racemase activity, acting on amino acids and derivatives
BHE83_01885	COG0697	spore germination
BHE83_01890	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BHE83_01895	COG0167	dihydroorotate dehydrogenase activity
BHE83_01910	COG1012	belongs to the aldehyde dehydrogenase family
BHE83_01925	COG2963	transposase activity
BHE83_01940	COG2801	Transposase and inactivated derivatives
BHE83_01950	COG2801	Transposase and inactivated derivatives
BHE83_01955	COG2963	transposase activity
BHE83_01970	COG2801	Transposase and inactivated derivatives
BHE83_01975	COG2801	Transposase and inactivated derivatives
BHE83_01980	COG2963	transposase activity
BHE83_02020	COG3210	domain, Protein
BHE83_02030	COG2963	transposase activity
BHE83_02040	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BHE83_02045	COG0460	homoserine dehydrogenase
BHE83_02045	COG0527	aspartate kinase activity
BHE83_02060	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BHE83_02070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BHE83_02075	COG0124	histidyl-tRNA synthetase
BHE83_02085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BHE83_02090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BHE83_02095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BHE83_02100	COG0131	Imidazoleglycerol-phosphate dehydratase
BHE83_02100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BHE83_02105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BHE83_02110	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BHE83_02115	COG0107	imidazoleglycerol-phosphate synthase activity
BHE83_02120	COG0140	phosphoribosyl-ATP diphosphatase activity
BHE83_02120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BHE83_02135	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BHE83_02140	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BHE83_02145	COG0235	Class ii aldolase
BHE83_02150	COG0531	amino acid
BHE83_02155	COG0531	amino acid
BHE83_02165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BHE83_02170	COG0277	FAD linked oxidase domain protein
BHE83_02190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BHE83_02235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BHE83_02240	COG2258	MOSC domain
BHE83_02245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BHE83_02250	COG0505	Belongs to the CarA family
BHE83_02260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BHE83_02265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BHE83_02275	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BHE83_02285	COG3279	Response regulator of the LytR AlgR family
BHE83_02290	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BHE83_02295	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BHE83_02310	COG2205	protein histidine kinase activity
BHE83_02310	COG0784	Response regulator, receiver
BHE83_02310	COG2198	Histidine kinase
BHE83_02315	COG1024	Enoyl-CoA hydratase
BHE83_02320	COG0318	PFAM AMP-dependent synthetase and ligase
BHE83_02350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BHE83_02360	COG2201	protein-glutamate methylesterase activity
BHE83_02365	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BHE83_02375	COG0840	transmembrane signaling receptor activity
BHE83_02385	COG0835	chemotaxis
BHE83_02395	COG0840	transmembrane signaling receptor activity
BHE83_02400	COG0840	transmembrane signaling receptor activity
BHE83_02405	COG0840	transmembrane signaling receptor activity
BHE83_02410	COG0840	transmembrane signaling receptor activity
BHE83_02415	COG0840	transmembrane signaling receptor activity
BHE83_02425	COG0840	transmembrane signaling receptor activity
BHE83_02430	COG0840	transmembrane signaling receptor activity
BHE83_02435	COG0840	transmembrane signaling receptor activity
BHE83_02450	COG0840	transmembrane signaling receptor activity
BHE83_02455	COG0840	transmembrane signaling receptor activity
BHE83_02465	COG0840	transmembrane signaling receptor activity
BHE83_02470	COG0840	transmembrane signaling receptor activity
BHE83_02480	COG0745	RESPONSE REGULATOR receiver
BHE83_02490	COG0835	chemotaxis
BHE83_02495	COG1192	Involved in chromosome partitioning
BHE83_02500	COG1360	Flagellar Motor Protein
BHE83_02505	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BHE83_02535	COG2963	transposase activity
BHE83_02565	COG0643	Histidine kinase
BHE83_02565	COG2198	Histidine kinase
BHE83_02585	COG0455	bacterial-type flagellum organization
BHE83_02610	COG5001	Diguanylate cyclase
BHE83_02610	COG3300	MHYT domain
BHE83_02615	COG3300	MHYT domain
BHE83_02615	COG5001	Diguanylate cyclase
BHE83_02620	COG1684	flagellar biosynthetic protein fliR
BHE83_02625	COG1987	bacterial-type flagellum assembly
BHE83_02635	COG3190	flagellar
BHE83_02685	COG1677	Flagellar hook-basal body complex protein FliE
BHE83_02695	COG0275	rRNA processing
BHE83_02700	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BHE83_02735	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_02740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BHE83_02755	COG2204	response regulator
BHE83_02760	COG2201	protein-glutamate methylesterase activity
BHE83_02790	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BHE83_02795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BHE83_02800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BHE83_02810	COG3951	Flagellar rod assembly protein muramidase FlgJ
BHE83_02810	COG1705	Flagellar rod assembly protein muramidase FlgJ
BHE83_02815	COG1706	bacterial-type flagellum-dependent cell motility
BHE83_02820	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BHE83_02825	COG4786	Flagellar basal body rod
BHE83_02835	COG4787	bacterial-type flagellum-dependent cell motility
BHE83_02840	COG1749	Flagellar hook protein flgE
BHE83_02845	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BHE83_02850	COG1558	bacterial-type flagellum-dependent cell motility
BHE83_02860	COG0835	chemotaxis
BHE83_02860	COG0784	Response regulator, receiver
BHE83_02880	COG5002	protein histidine kinase activity
BHE83_02910	COG2915	High frequency lysogenization protein hflD homolog
BHE83_02915	COG0482	sulfurtransferase activity
BHE83_02925	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BHE83_02930	COG0542	response to heat
BHE83_02935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BHE83_02940	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BHE83_02955	COG0492	ferredoxin-NADP+ reductase activity
BHE83_02960	COG1674	ftsk spoiiie
BHE83_02970	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BHE83_02980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BHE83_02985	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BHE83_02990	COG0183	Belongs to the thiolase family
BHE83_02995	COG1250	3-hydroxyacyl-CoA dehydrogenase
BHE83_02995	COG1024	Enoyl-CoA hydratase
BHE83_03005	COG0105	UTP biosynthetic process
BHE83_03010	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BHE83_03020	COG1426	Protein conserved in bacteria
BHE83_03030	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BHE83_03035	COG1160	GTP binding
BHE83_03040	COG0303	'Molybdopterin
BHE83_03045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BHE83_03085	COG0708	Exodeoxyribonuclease III
BHE83_03095	COG0303	'Molybdopterin
BHE83_03100	COG0746	molybdenum cofactor guanylyltransferase activity
BHE83_03125	COG1648	precorrin-2 dehydrogenase activity
BHE83_03125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BHE83_03135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BHE83_03140	COG2223	nitrite transmembrane transporter activity
BHE83_03145	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BHE83_03155	COG0243	molybdopterin cofactor binding
BHE83_03170	COG3685	Protein conserved in bacteria
BHE83_03190	COG5001	Diguanylate cyclase
BHE83_03200	COG4566	intracellular signal transduction
BHE83_03220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHE83_03240	COG3279	Response regulator of the LytR AlgR family
BHE83_03345	COG3501	Rhs element vgr protein
BHE83_03380	COG0631	protein serine/threonine phosphatase activity
BHE83_03385	COG0515	serine threonine protein kinase
BHE83_03415	COG1858	cytochrome C peroxidase
BHE83_03445	COG4585	Histidine kinase
BHE83_03450	COG2197	response regulator
BHE83_03470	COG2801	Transposase and inactivated derivatives
BHE83_03510	COG1002	Type II restriction enzyme, methylase subunits
BHE83_03515	COG1061	Type III restriction enzyme res subunit
BHE83_03520	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BHE83_03525	COG1196	nuclear chromosome segregation
BHE83_03545	COG2818	Glycosylase
BHE83_03550	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_03560	COG0583	DNA-binding transcription factor activity
BHE83_03570	COG3002	Belongs to the UPF0753 family
BHE83_03575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BHE83_03580	COG0583	DNA-binding transcription factor activity
BHE83_03590	COG0633	Ferredoxin
BHE83_03610	COG0583	DNA-binding transcription factor activity
BHE83_03630	COG2197	response regulator
BHE83_03635	COG4585	Histidine kinase
BHE83_03645	COG1335	isochorismatase
BHE83_03660	COG2814	Major facilitator Superfamily
BHE83_03680	COG1914	H( )-stimulated, divalent metal cation uptake system
BHE83_03685	COG1321	iron dependent repressor
BHE83_03690	COG0590	tRNA wobble adenosine to inosine editing
BHE83_03695	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BHE83_03700	COG0668	transmembrane transport
BHE83_03710	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BHE83_03725	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_03730	COG1183	phosphatidylcholine synthase activity
BHE83_03740	COG3243	poly(R)-hydroxyalkanoic acid synthase
BHE83_03755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BHE83_03755	COG0723	plastoquinol--plastocyanin reductase activity
BHE83_03765	COG2183	response to ionizing radiation
BHE83_03770	COG2205	protein histidine kinase activity
BHE83_03770	COG0784	Response regulator, receiver
BHE83_03785	COG0582	viral genome integration into host DNA
BHE83_03860	COG0800	Aldolase
BHE83_03865	COG0129	dihydroxy-acid dehydratase activity
BHE83_03870	COG0363	glucosamine-6-phosphate deaminase activity
BHE83_03875	COG0837	glucose binding
BHE83_03880	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BHE83_03890	COG0354	folic acid binding
BHE83_03900	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BHE83_03915	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BHE83_03920	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BHE83_03930	COG4591	ABC-type transport system involved in lipoprotein release permease component
BHE83_03935	COG1136	(ABC) transporter
BHE83_03950	COG0811	peptide transport
BHE83_03960	COG1132	(ABC) transporter
BHE83_03965	COG1663	tetraacyldisaccharide 4'-kinase activity
BHE83_03970	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BHE83_03975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BHE83_03985	COG0322	excinuclease ABC activity
BHE83_03990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BHE83_04005	COG2801	Transposase and inactivated derivatives
BHE83_04050	COG2826	transposase and inactivated derivatives, IS30 family
BHE83_04060	COG4644	lycopene metabolic process
BHE83_04115	COG0270	DNA (cytosine-5-)-methyltransferase activity
BHE83_04125	COG0629	single-stranded DNA binding
BHE83_04165	COG2801	Transposase and inactivated derivatives
BHE83_04185	COG0582	viral genome integration into host DNA
BHE83_04195	COG1396	sequence-specific DNA binding
BHE83_04200	COG0583	DNA-binding transcription factor activity
BHE83_04230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BHE83_04235	COG4232	protein-disulfide reductase activity
BHE83_04240	COG0745	RESPONSE REGULATOR receiver
BHE83_04250	COG0492	ferredoxin-NADP+ reductase activity
BHE83_04270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BHE83_04275	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BHE83_04285	COG1275	C4-dicarboxylate transporter malic acid transport protein
BHE83_04295	COG3316	Transposase and inactivated derivatives
BHE83_04315	COG1573	uracil-dna glycosylase
BHE83_04330	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BHE83_04340	COG3316	Transposase and inactivated derivatives
BHE83_04355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BHE83_04365	COG2814	Major facilitator Superfamily
BHE83_04370	COG0789	Transcriptional regulator
BHE83_04380	COG0640	Transcriptional regulator
BHE83_04385	COG1230	cation diffusion facilitator family transporter
BHE83_04395	COG3316	Transposase and inactivated derivatives
BHE83_04455	COG2801	Transposase and inactivated derivatives
BHE83_04460	COG3316	Transposase and inactivated derivatives
BHE83_04465	COG0583	DNA-binding transcription factor activity
BHE83_04520	COG2003	Belongs to the UPF0758 family
BHE83_04720	COG0270	DNA (cytosine-5-)-methyltransferase activity
BHE83_04725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BHE83_04730	COG0629	single-stranded DNA binding
BHE83_04765	COG1192	Involved in chromosome partitioning
BHE83_04785	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BHE83_04815	COG1530	ribonuclease E activity
BHE83_04825	COG3064	Membrane
BHE83_04830	COG0428	transporter
BHE83_04840	COG2154	pterin-4-alpha-carbinolamine dehydratase
BHE83_04845	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BHE83_04845	COG0316	Belongs to the HesB IscA family
BHE83_04860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHE83_04865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BHE83_04895	COG4644	lycopene metabolic process
BHE83_04900	COG2951	lytic endotransglycosylase activity
BHE83_04930	COG0640	Transcriptional regulator
BHE83_05050	COG1484	DNA-dependent DNA replication
BHE83_05060	COG2801	Transposase and inactivated derivatives
BHE83_05090	COG0582	viral genome integration into host DNA
BHE83_05095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BHE83_05095	COG0519	Catalyzes the synthesis of GMP from XMP
BHE83_05105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BHE83_05115	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BHE83_05115	COG0475	glutathione-regulated potassium exporter activity
BHE83_05120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BHE83_05130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BHE83_05135	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BHE83_05145	COG0776	regulation of translation
BHE83_05150	COG0539	negative regulation of cytoplasmic translation
BHE83_05155	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BHE83_05160	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BHE83_05170	COG2957	Belongs to the agmatine deiminase family
BHE83_05175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BHE83_05200	COG0395	ABC-type sugar transport system, permease component
BHE83_05205	COG1175	transmembrane transport
BHE83_05235	COG2350	Protein conserved in bacteria
BHE83_05240	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BHE83_05245	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BHE83_05250	COG1187	pseudouridine synthase activity
BHE83_05270	COG0436	Aminotransferase
BHE83_05275	COG4133	protoheme IX ABC transporter activity
BHE83_05295	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BHE83_05300	COG1138	Cytochrome C-type biogenesis protein
BHE83_05320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BHE83_05325	COG1278	Cold shock
BHE83_05330	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BHE83_05335	COG4988	ABC transporter
BHE83_05345	COG1294	oxidase, subunit
BHE83_05375	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BHE83_05380	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BHE83_05390	COG0165	Argininosuccinate lyase
BHE83_05395	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BHE83_05405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BHE83_05420	COG0137	argininosuccinate synthase activity
BHE83_05425	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BHE83_05435	COG0215	cysteine-tRNA ligase activity
BHE83_05440	COG2166	iron-sulfur cluster assembly
BHE83_05450	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BHE83_05455	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BHE83_05460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BHE83_05480	COG4303	Ethanolamine ammonia lyase large subunit
BHE83_05530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BHE83_05535	COG0402	S-adenosylhomocysteine deaminase activity
BHE83_05545	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BHE83_05550	COG1509	lysine 2,3-aminomutase activity
BHE83_05555	COG3300	MHYT domain
BHE83_05555	COG5001	Diguanylate cyclase
BHE83_05570	COG0483	inositol monophosphate 1-phosphatase activity
BHE83_05595	COG0513	Belongs to the DEAD box helicase family
BHE83_05600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BHE83_05605	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BHE83_05615	COG0625	glutathione transferase activity
BHE83_05625	COG4681	YaeQ
BHE83_05630	COG2081	HI0933 family
BHE83_05640	COG0501	Belongs to the peptidase M48B family
BHE83_05645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BHE83_05650	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_05675	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BHE83_05680	COG0860	N-Acetylmuramoyl-L-alanine amidase
BHE83_05685	COG0802	atpase or kinase
BHE83_05690	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BHE83_05690	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BHE83_05695	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BHE83_05700	COG1570	exodeoxyribonuclease VII activity
BHE83_05710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BHE83_05745	COG0582	viral genome integration into host DNA
BHE83_05755	COG2963	transposase activity
BHE83_05790	COG0835	chemotaxis
BHE83_05795	COG0840	transmembrane signaling receptor activity
BHE83_05800	COG2094	Belongs to the DNA glycosylase MPG family
BHE83_05805	COG1201	RNA secondary structure unwinding
BHE83_05825	COG2969	positive regulation of protein catabolic process
BHE83_05830	COG0625	glutathione transferase activity
BHE83_05835	COG2857	Cytochrome c1
BHE83_05840	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BHE83_05845	COG0723	plastoquinol--plastocyanin reductase activity
BHE83_05850	COG0741	lytic transglycosylase activity
BHE83_05865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BHE83_05870	COG1702	phosphate starvation-inducible protein PhoH
BHE83_05880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BHE83_05890	COG4535	Mg2 and Co2 transporter CorC
BHE83_05905	COG1012	belongs to the aldehyde dehydrogenase family
BHE83_05915	COG1177	transmembrane transport
BHE83_05920	COG1176	ABC-type spermidine putrescine transport system, permease component I
BHE83_05950	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BHE83_05965	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BHE83_05970	COG0174	glutamine synthetase
BHE83_05975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BHE83_05980	COG3706	GGDEF domain
BHE83_05980	COG0745	RESPONSE REGULATOR receiver
BHE83_05985	COG2703	oxygen carrier activity
BHE83_05990	COG0477	Major facilitator Superfamily
BHE83_06000	COG0243	molybdopterin cofactor binding
BHE83_06005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BHE83_06025	COG2733	membrane
BHE83_06030	COG2205	protein histidine kinase activity
BHE83_06030	COG0784	Response regulator, receiver
BHE83_06030	COG5002	protein histidine kinase activity
BHE83_06040	COG0477	Major facilitator Superfamily
BHE83_06045	COG2902	Dehydrogenase
BHE83_06055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHE83_06060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BHE83_06065	COG1609	Transcriptional regulator
BHE83_06070	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BHE83_06070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BHE83_06075	COG1105	Belongs to the carbohydrate kinase PfkB family
BHE83_06080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BHE83_06080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BHE83_06120	COG2801	Transposase and inactivated derivatives
BHE83_06130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BHE83_06140	COG1862	Preprotein translocase
BHE83_06145	COG0343	queuine tRNA-ribosyltransferase activity
BHE83_06150	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BHE83_06190	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BHE83_06195	COG3291	Pkd domain containing protein
BHE83_06205	COG0405	Gamma-glutamyltransferase
BHE83_06210	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BHE83_06225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BHE83_06230	COG0742	ribosomal rna small subunit methyltransferase
BHE83_06235	COG0326	Molecular chaperone. Has ATPase activity
BHE83_06270	COG2963	transposase activity
BHE83_06345	COG0531	amino acid
BHE83_06360	COG0006	proline dipeptidase activity
BHE83_06370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BHE83_06385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BHE83_06390	COG3938	Belongs to the proline racemase family
BHE83_06400	COG0552	protein localization to endoplasmic reticulum
BHE83_06405	COG1194	a g-specific adenine glycosylase
BHE83_06410	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BHE83_06415	COG4191	Histidine kinase
BHE83_06415	COG0784	Response regulator, receiver
BHE83_06445	COG3040	lipid binding
BHE83_06455	COG1960	acyl-CoA dehydrogenase activity
BHE83_06465	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BHE83_06485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BHE83_06490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BHE83_06495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BHE83_06510	COG2963	transposase activity
BHE83_06545	COG0438	transferase activity, transferring glycosyl groups
BHE83_06550	COG0438	transferase activity, transferring glycosyl groups
BHE83_06595	COG0776	regulation of translation
BHE83_06600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BHE83_06600	COG0072	phenylalanine-tRNA ligase activity
BHE83_06605	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BHE83_06610	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BHE83_06615	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BHE83_06620	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BHE83_06625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BHE83_06650	COG1082	Xylose isomerase domain protein TIM barrel
BHE83_06665	COG0366	Alpha amylase catalytic
BHE83_06675	COG2963	transposase activity
BHE83_06695	COG3505	Type IV secretory pathway VirD4
BHE83_06715	COG0556	nucleotide-excision repair
BHE83_06745	COG2963	transposase activity
BHE83_06760	COG1611	Belongs to the LOG family
BHE83_06770	COG2095	MarC family integral membrane protein
BHE83_06780	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BHE83_06785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BHE83_06815	COG1185	polyribonucleotide nucleotidyltransferase activity
BHE83_06820	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BHE83_06825	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BHE83_06830	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BHE83_06835	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BHE83_06840	COG0195	Participates in both transcription termination and antitermination
BHE83_06845	COG0779	Required for maturation of 30S ribosomal subunits
BHE83_06855	COG1007	ATP synthesis coupled electron transport
BHE83_06870	COG0713	ATP synthesis coupled electron transport
BHE83_06880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BHE83_06885	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BHE83_06890	COG1034	ATP synthesis coupled electron transport
BHE83_06895	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BHE83_06900	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BHE83_06905	COG0649	NAD binding
BHE83_06910	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BHE83_06915	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BHE83_06920	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BHE83_06935	COG0149	triose-phosphate isomerase activity
BHE83_06940	COG4221	oxidoreductase activity
BHE83_06980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BHE83_06985	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BHE83_06990	COG0159	tryptophan synthase activity
BHE83_07000	COG2801	Transposase and inactivated derivatives
BHE83_07015	COG0133	tryptophan synthase activity
BHE83_07025	COG0135	phosphoribosylanthranilate isomerase activity
BHE83_07030	COG0101	tRNA pseudouridine synthase activity
BHE83_07050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BHE83_07055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BHE83_07060	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BHE83_07065	COG2890	protein-(glutamine-N5) methyltransferase activity
BHE83_07075	COG0688	phosphatidylethanolamine metabolic process
BHE83_07085	COG0433	COG0433 Predicted ATPase
BHE83_07090	COG0494	nUDIX hydrolase
BHE83_07105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BHE83_07110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BHE83_07135	COG0717	Belongs to the dCTP deaminase family
BHE83_07140	COG0489	protein tyrosine kinase activity
BHE83_07160	COG3590	peptidase
BHE83_07165	COG3590	peptidase
BHE83_07185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BHE83_07190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BHE83_07195	COG2311	Membrane
BHE83_07200	COG1047	Peptidyl-prolyl cis-trans
BHE83_07205	COG0791	NLP P60 protein
BHE83_07210	COG0791	NLP P60 protein
BHE83_07225	COG1301	dicarboxylic acid transport
BHE83_07230	COG1785	Belongs to the alkaline phosphatase family
BHE83_07235	COG0037	tRNA processing
BHE83_07240	COG1722	exodeoxyribonuclease VII activity
BHE83_07245	COG0142	geranyltranstransferase activity
BHE83_07250	COG4104	PAAR repeat-containing protein
BHE83_07260	COG0312	modulator of DNA gyrase
BHE83_07265	COG3028	Belongs to the UPF0307 family
BHE83_07270	COG0312	modulator of DNA gyrase
BHE83_07280	COG3164	Protein of unknown function
BHE83_07285	COG1530	ribonuclease E activity
BHE83_07290	COG0424	maF-like protein
BHE83_07295	COG2968	Membrane
BHE83_07305	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BHE83_07320	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BHE83_07335	COG0495	leucyl-tRNA aminoacylation
BHE83_07345	COG3118	belongs to the thioredoxin family
BHE83_07375	COG2155	Conserved Protein
BHE83_07380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BHE83_07430	COG1132	(ABC) transporter
BHE83_07455	COG1538	Outer membrane efflux protein
BHE83_07460	COG0745	RESPONSE REGULATOR receiver
BHE83_07470	COG0475	glutathione-regulated potassium exporter activity
BHE83_07475	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BHE83_07480	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BHE83_07500	COG3706	GGDEF domain
BHE83_07505	COG1187	pseudouridine synthase activity
BHE83_07510	COG5001	Diguanylate cyclase
BHE83_07510	COG5002	protein histidine kinase activity
BHE83_07615	COG0667	Aldo Keto reductase
BHE83_07620	COG2814	Major facilitator Superfamily
BHE83_07625	COG0583	DNA-binding transcription factor activity
BHE83_07635	COG2207	Transcriptional regulator
BHE83_07650	COG1309	transcriptional regulator
BHE83_07655	COG1538	Outer membrane efflux protein
BHE83_07675	COG0735	belongs to the Fur family
BHE83_07680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BHE83_07705	COG4452	Inner membrane protein CreD
BHE83_07720	COG2205	protein histidine kinase activity
BHE83_07725	COG0745	RESPONSE REGULATOR receiver
BHE83_07730	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BHE83_07740	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BHE83_07750	COG2198	Histidine kinase
BHE83_07750	COG0643	Histidine kinase
BHE83_07755	COG0840	transmembrane signaling receptor activity
BHE83_07760	COG0835	chemotaxis
BHE83_07765	COG2200	EAL domain
BHE83_07765	COG2202	Pas domain
BHE83_07765	COG2199	diguanylate cyclase activity
BHE83_07770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BHE83_07775	COG2201	protein-glutamate methylesterase activity
BHE83_07780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BHE83_07785	COG3590	peptidase
BHE83_07795	COG0588	phosphoglycerate mutase activity
BHE83_07800	COG1515	deoxyribonuclease V activity
BHE83_07810	COG1741	Belongs to the pirin family
BHE83_07825	COG1741	Belongs to the pirin family
BHE83_07830	COG1966	Carbon starvation protein
BHE83_07835	COG2879	small protein
BHE83_07880	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BHE83_07885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BHE83_07890	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BHE83_07895	COG2080	2 iron, 2 sulfur cluster binding
BHE83_07900	COG3321	synthase
BHE83_07900	COG0604	alcohol dehydrogenase
BHE83_07900	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_07905	COG5001	Diguanylate cyclase
BHE83_07905	COG2203	Gaf domain
BHE83_07905	COG4251	negative regulation of phosphorylation
BHE83_07905	COG3706	GGDEF domain
BHE83_07910	COG0629	single-stranded DNA binding
BHE83_07915	COG0142	geranyltranstransferase activity
BHE83_07930	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BHE83_07945	COG0527	aspartate kinase activity
BHE83_07950	COG0384	phenazine biosynthesis protein PhzF
BHE83_07955	COG0384	phenazine biosynthesis protein PhzF
BHE83_07965	COG1764	response to oxidative stress
BHE83_07970	COG0540	Belongs to the ATCase OTCase family
BHE83_07975	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BHE83_07980	COG1678	Uncharacterized ACR, COG1678
BHE83_07990	COG0519	Catalyzes the synthesis of GMP from XMP
BHE83_08015	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BHE83_08030	COG0739	heme binding
BHE83_08050	COG0693	protein deglycase activity
BHE83_08060	COG1959	2 iron, 2 sulfur cluster binding
BHE83_08065	COG0719	Fe-S assembly protein
BHE83_08070	COG0396	ATPase activity
BHE83_08075	COG0719	Fe-S assembly protein
BHE83_08080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BHE83_08095	COG4774	siderophore transport
BHE83_08100	COG3128	pkhd-type hydroxylase
BHE83_08125	COG1477	protein flavinylation
BHE83_08130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BHE83_08145	COG1555	photosystem II stabilization
BHE83_08165	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BHE83_08175	COG0628	permease
BHE83_08185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BHE83_08195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BHE83_08215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BHE83_08220	COG0271	Belongs to the BolA IbaG family
BHE83_08230	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BHE83_08240	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BHE83_08245	COG1137	ATPase activity
BHE83_08260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BHE83_08265	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BHE83_08270	COG1660	Displays ATPase and GTPase activities
BHE83_08280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BHE83_08285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BHE83_08290	COG2239	Acts as a magnesium transporter
BHE83_08300	COG1294	oxidase, subunit
BHE83_08305	COG1271	oxidase subunit
BHE83_08315	COG1113	amino acid transport
BHE83_08335	COG2197	response regulator
BHE83_08340	COG0531	amino acid
BHE83_08410	COG2814	Major facilitator Superfamily
BHE83_08415	COG0754	glutathionylspermidine amidase activity
BHE83_08440	COG1842	Phage shock protein A
BHE83_08450	COG0259	pyridoxamine-phosphate oxidase activity
BHE83_08455	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BHE83_08460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BHE83_08470	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BHE83_08475	COG2814	Major facilitator Superfamily
BHE83_08505	COG2353	YceI-like domain
BHE83_08525	COG1760	l-serine dehydratase
BHE83_08535	COG0460	homoserine dehydrogenase
BHE83_08535	COG0527	aspartate kinase activity
BHE83_08540	COG0626	cystathionine gamma-synthase activity
BHE83_08545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BHE83_08550	COG0739	heme binding
BHE83_08555	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BHE83_08560	COG1272	protein, Hemolysin III
BHE83_08565	COG2982	Protein involved in outer membrane biogenesis
BHE83_08570	COG0516	GMP reductase activity
BHE83_08570	COG0517	IMP dehydrogenase activity
BHE83_08575	COG0463	Glycosyl transferase, family 2
BHE83_08580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BHE83_08585	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BHE83_08600	COG1309	transcriptional regulator
BHE83_08605	COG2267	carboxylic ester hydrolase activity
BHE83_08610	COG1960	acyl-CoA dehydrogenase activity
BHE83_08635	COG0509	glycine decarboxylation via glycine cleavage system
BHE83_08640	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BHE83_08650	COG1742	UPF0060 membrane protein
BHE83_08655	COG3956	TIGRFAM MazG family protein
BHE83_08665	COG0494	nUDIX hydrolase
BHE83_08675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BHE83_08680	COG0837	glucose binding
BHE83_08695	COG1388	LysM domain
BHE83_08695	COG3858	chitin binding
BHE83_08700	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BHE83_08710	COG1472	Belongs to the glycosyl hydrolase 3 family
BHE83_08720	COG3537	Alpha-1,2-mannosidase
BHE83_08755	COG3142	Participates in the control of copper homeostasis
BHE83_08760	COG1446	asparaginase
BHE83_08765	COG2304	oxidoreductase activity
BHE83_08770	COG1595	DNA-templated transcription, initiation
BHE83_08805	COG0840	transmembrane signaling receptor activity
BHE83_08810	COG0835	chemotaxis
BHE83_08825	COG0189	ligase activity
BHE83_08855	COG1199	ATP-dependent helicase activity
BHE83_08865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BHE83_08870	COG1215	transferase activity, transferring glycosyl groups
BHE83_08880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BHE83_08885	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BHE83_08890	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
BHE83_08895	COG0535	radical SAM domain protein
BHE83_08900	COG0535	radical SAM domain protein
BHE83_08920	COG0837	glucose binding
BHE83_08930	COG1643	Atp-dependent helicase
BHE83_08935	COG0783	Belongs to the Dps family
BHE83_08940	COG0514	ATP-dependent DNA helicase (RecQ)
BHE83_08970	COG1187	pseudouridine synthase activity
BHE83_08980	COG0840	transmembrane signaling receptor activity
BHE83_09000	COG3920	Histidine kinase
BHE83_09005	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BHE83_09015	COG0602	queuosine metabolic process
BHE83_09025	COG2885	chlorophyll binding
BHE83_09030	COG0823	Involved in the tonB-independent uptake of proteins
BHE83_09040	COG0848	biopolymer transport protein
BHE83_09050	COG0824	Thioesterase
BHE83_09055	COG2255	four-way junction helicase activity
BHE83_09065	COG3158	transport of potassium into the cell
BHE83_09070	COG0632	four-way junction helicase activity
BHE83_09075	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BHE83_09080	COG0217	transcriptional regulatory protein
BHE83_09095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BHE83_09110	COG0477	Major facilitator Superfamily
BHE83_09125	COG0657	acetylesterase activity
BHE83_09125	COG2755	lipolytic protein G-D-S-L family
BHE83_09145	COG0488	(ABC) transporter
BHE83_09185	COG4772	TonB-dependent receptor
BHE83_09195	COG4264	IucA IucC family
BHE83_09200	COG2814	Major facilitator Superfamily
BHE83_09210	COG0019	diaminopimelate decarboxylase activity
BHE83_09230	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BHE83_09240	COG1492	cobalamin metabolic process
BHE83_09250	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BHE83_09270	COG4206	TonB-dependent receptor
BHE83_09275	COG0542	response to heat
BHE83_09315	COG4771	TonB-dependent receptor
BHE83_09320	COG1877	trehalose-phosphatase activity
BHE83_09325	COG3387	PFAM Glycoside hydrolase 15-related
BHE83_09340	COG0840	transmembrane signaling receptor activity
BHE83_09345	COG3011	Protein conserved in bacteria
BHE83_09360	COG0564	pseudouridine synthase activity
BHE83_09365	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BHE83_09375	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BHE83_09375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BHE83_09390	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BHE83_09395	COG0045	succinate-CoA ligase (ADP-forming) activity
BHE83_09420	COG4969	Belongs to the N-Me-Phe pilin family
BHE83_09430	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BHE83_09435	COG0237	dephospho-CoA kinase activity
BHE83_09445	COG2963	transposase activity
BHE83_09455	COG2963	transposase activity
BHE83_09460	COG2801	Transposase and inactivated derivatives
BHE83_09470	COG0745	RESPONSE REGULATOR receiver
BHE83_09480	COG0189	ligase activity
BHE83_09540	COG2801	Transposase and inactivated derivatives
BHE83_09550	COG2963	transposase activity
BHE83_09585	COG3039	Transposase
BHE83_09600	COG2801	Transposase and inactivated derivatives
BHE83_09615	COG3220	belongs to the UPF0276 family
BHE83_09630	COG2003	Belongs to the UPF0758 family
BHE83_09650	COG2801	Transposase and inactivated derivatives
BHE83_09690	COG2022	thiamine diphosphate biosynthetic process
BHE83_09700	COG0471	metal ion transport
BHE83_09700	COG3273	potassium ion transport
BHE83_09720	COG1970	mechanosensitive ion channel activity
BHE83_09735	COG1609	Transcriptional regulator
BHE83_09745	COG3250	beta-galactosidase activity
BHE83_09750	COG4948	Mandelate Racemase Muconate Lactonizing
BHE83_09765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BHE83_09780	COG0308	aminopeptidase N
BHE83_09810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BHE83_09825	COG0529	Catalyzes the synthesis of activated sulfate
BHE83_09825	COG2895	sulfate adenylyltransferase (ATP) activity
BHE83_09830	COG0175	sulfate reduction
BHE83_09835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BHE83_09840	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BHE83_09845	COG0175	sulfate reduction
BHE83_09885	COG1648	precorrin-2 dehydrogenase activity
BHE83_09885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BHE83_09900	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BHE83_09905	COG3588	fructose-bisphosphate aldolase
BHE83_09910	COG0469	pyruvate kinase activity
BHE83_09920	COG0126	phosphoglycerate kinase activity
BHE83_09940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BHE83_09950	COG3047	cAMP biosynthetic process
BHE83_09955	COG3047	cAMP biosynthetic process
BHE83_09965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BHE83_09965	COG3453	Protein conserved in bacteria
BHE83_09970	COG0725	ABC transporter, periplasmic molybdate-binding protein
BHE83_09975	COG4149	molybdate abc transporter
BHE83_09980	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BHE83_10015	COG1376	ErfK ybiS ycfS ynhG family protein
BHE83_10020	COG0739	heme binding
BHE83_10025	COG4773	Receptor
BHE83_10030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BHE83_10035	COG1301	dicarboxylic acid transport
BHE83_10045	COG2304	oxidoreductase activity
BHE83_10065	COG0714	Associated with various cellular activities
BHE83_10095	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BHE83_10110	COG0254	rRNA binding
BHE83_10115	COG1957	nucleoside hydrolase
BHE83_10120	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BHE83_10130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BHE83_10135	COG1758	RNA polymerase activity
BHE83_10140	COG0194	GDP metabolic process
BHE83_10145	COG1561	YicC-like family, N-terminal region
BHE83_10150	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BHE83_10160	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BHE83_10165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BHE83_10180	COG0006	proline dipeptidase activity
BHE83_10190	COG0006	proline dipeptidase activity
BHE83_10195	COG3079	Belongs to the UPF0149 family
BHE83_10215	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BHE83_10225	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BHE83_10235	COG2912	Transglutaminase-like superfamily
BHE83_10240	COG1773	rubredoxin
BHE83_10245	COG0352	thiamine-phosphate diphosphorylase activity
BHE83_10255	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BHE83_10270	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BHE83_10275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BHE83_10305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BHE83_10310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BHE83_10315	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_10325	COG0671	phosphoesterase, PA-phosphatase related
BHE83_10330	COG3781	membrane
BHE83_10340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BHE83_10345	COG0563	adenylate kinase activity
BHE83_10410	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BHE83_10420	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BHE83_10440	COG3710	Transcriptional regulator
BHE83_10445	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BHE83_10455	COG0840	transmembrane signaling receptor activity
BHE83_10460	COG0405	Gamma-glutamyltransferase
BHE83_10465	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BHE83_10485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BHE83_10490	COG0473	3-isopropylmalate dehydrogenase activity
BHE83_10495	COG0066	3-isopropylmalate dehydratase activity
BHE83_10500	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BHE83_10520	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BHE83_10525	COG1538	Outer membrane efflux protein
BHE83_10530	COG1519	Transferase
BHE83_10535	COG1560	Kdo2-lipid A biosynthetic process
BHE83_10560	COG0281	malic enzyme
BHE83_10560	COG0280	phosphate acetyltransferase
BHE83_10565	COG1301	dicarboxylic acid transport
BHE83_10595	COG0583	DNA-binding transcription factor activity
BHE83_10605	COG0667	Aldo Keto reductase
BHE83_10620	COG2197	response regulator
BHE83_10625	COG1840	ABC-type Fe3 transport system, periplasmic component
BHE83_10630	COG0642	Histidine kinase
BHE83_10645	COG2851	Citrate transporter
BHE83_10650	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_10655	COG1609	Transcriptional regulator
BHE83_10660	COG2211	Major facilitator Superfamily
BHE83_10685	COG1162	GTPase activity
BHE83_10705	COG0726	polysaccharide deacetylase
BHE83_10710	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BHE83_10725	COG3964	amidohydrolase
BHE83_10730	COG0402	S-adenosylhomocysteine deaminase activity
BHE83_10750	COG1307	EDD domain protein, DegV family
BHE83_10755	COG0242	peptide deformylase activity
BHE83_10775	COG0457	Tetratricopeptide repeat
BHE83_10780	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BHE83_10785	COG1215	transferase activity, transferring glycosyl groups
BHE83_10805	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BHE83_10860	COG1450	Type ii and iii secretion system protein
BHE83_10875	COG3166	PFAM Fimbrial assembly family protein
BHE83_10880	COG3156	type II secretion system protein K
BHE83_10885	COG4795	General secretion pathway protein
BHE83_10890	COG2165	general secretion pathway protein
BHE83_10895	COG4970	Tfp pilus assembly protein FimT
BHE83_10900	COG2165	general secretion pathway protein
BHE83_10905	COG1459	type II secretion system
BHE83_10910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BHE83_10915	COG1404	Belongs to the peptidase S8 family
BHE83_10920	COG5295	Hep Hag repeat protein
BHE83_10925	COG1404	Belongs to the peptidase S8 family
BHE83_10930	COG5295	Hep Hag repeat protein
BHE83_10935	COG0047	phosphoribosylformylglycinamidine synthase activity
BHE83_10935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BHE83_10940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BHE83_10945	COG4974	Belongs to the 'phage' integrase family
BHE83_10960	COG0795	lipopolysaccharide-transporting ATPase activity
BHE83_10970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BHE83_10985	COG0525	valine-tRNA ligase activity
BHE83_11020	COG1183	phosphatidylcholine synthase activity
BHE83_11030	COG0442	prolyl-tRNA aminoacylation
BHE83_11045	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BHE83_11050	COG1127	ABC transporter
BHE83_11055	COG3218	ABC-type transport auxiliary lipoprotein component
BHE83_11055	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BHE83_11080	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BHE83_11085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BHE83_11090	COG0662	Cupin 2, conserved barrel domain protein
BHE83_11090	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BHE83_11120	COG2086	electron transfer activity
BHE83_11135	COG0463	Glycosyl transferase, family 2
BHE83_11160	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BHE83_11165	COG0438	transferase activity, transferring glycosyl groups
BHE83_11185	COG0438	transferase activity, transferring glycosyl groups
BHE83_11190	COG0626	cystathionine gamma-synthase activity
BHE83_11220	COG0625	glutathione transferase activity
BHE83_11230	COG0513	Belongs to the DEAD box helicase family
BHE83_11235	COG0720	synthase
BHE83_11245	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BHE83_11250	COG1956	GAF domain-containing protein
BHE83_11265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BHE83_11270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BHE83_11285	COG0339	signal peptide processing
BHE83_11335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BHE83_11340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHE83_11345	COG1136	(ABC) transporter
BHE83_11350	COG0577	efflux transmembrane transporter activity
BHE83_11365	COG2204	response regulator
BHE83_11370	COG4191	Histidine kinase
BHE83_11375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BHE83_11390	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BHE83_11395	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BHE83_11400	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BHE83_11405	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BHE83_11410	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BHE83_11415	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BHE83_11425	COG0356	it plays a direct role in the translocation of protons across the membrane
BHE83_11445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BHE83_11455	COG0508	dehydrogenase complex catalyzes the overall conversion of
BHE83_11500	COG2011	ABC-type metal ion transport system permease component
BHE83_11505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BHE83_11510	COG0697	spore germination
BHE83_11515	COG1666	GTP binding
BHE83_11525	COG2198	Histidine kinase
BHE83_11525	COG5002	protein histidine kinase activity
BHE83_11525	COG0784	Response regulator, receiver
BHE83_11550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BHE83_11555	COG1187	pseudouridine synthase activity
BHE83_11560	COG2813	Specifically methylates the guanine in position
BHE83_11580	COG2205	protein histidine kinase activity
BHE83_11580	COG2202	Pas domain
BHE83_11600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BHE83_11605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BHE83_11610	COG1522	sequence-specific DNA binding
BHE83_11660	COG0842	Transport permease protein
BHE83_11665	COG1131	(ABC) transporter
BHE83_11670	COG0025	NhaP-type Na H and K H
BHE83_11675	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BHE83_11680	COG1573	uracil-dna glycosylase
BHE83_11690	COG3384	dioxygenase
BHE83_11695	COG0583	DNA-binding transcription factor activity
BHE83_11720	COG3590	peptidase
BHE83_11735	COG0531	amino acid
BHE83_11750	COG2972	Histidine kinase
BHE83_11765	COG3685	Protein conserved in bacteria
BHE83_11770	COG3546	catalase activity
BHE83_11810	COG1271	oxidase subunit
BHE83_11815	COG1294	oxidase, subunit
BHE83_11830	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_11835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BHE83_11855	COG1132	(ABC) transporter
BHE83_11870	COG1063	alcohol dehydrogenase
BHE83_11945	COG0251	oxidation-reduction process
BHE83_11965	COG0583	DNA-binding transcription factor activity
BHE83_11970	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BHE83_12000	COG0659	secondary active sulfate transmembrane transporter activity
BHE83_12005	COG0038	chloride channel
BHE83_12015	COG0024	Methionine aminopeptidase
BHE83_12030	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_12085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BHE83_12090	COG1490	D-aminoacyl-tRNA deacylase activity
BHE83_12095	COG1560	Kdo2-lipid A biosynthetic process
BHE83_12150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BHE83_12150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BHE83_12155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BHE83_12160	COG0242	peptide deformylase activity
BHE83_12165	COG1652	LysM domain
BHE83_12170	COG0758	DNA mediated transformation
BHE83_12175	COG2922	Belongs to the Smg family
BHE83_12190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BHE83_12190	COG1754	DNA topoisomerase type I activity
BHE83_12195	COG0009	L-threonylcarbamoyladenylate synthase
BHE83_12210	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_12220	COG0616	signal peptide processing
BHE83_12225	COG0534	Mate efflux family protein
BHE83_12245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BHE83_12265	COG1252	NADH dehydrogenase
BHE83_12270	COG2860	membrane
BHE83_12275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BHE83_12280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BHE83_12285	COG2201	protein-glutamate methylesterase activity
BHE83_12290	COG2177	Part of the ABC transporter FtsEX involved in
BHE83_12295	COG2884	Cell division ATP-binding protein ftsE
BHE83_12300	COG0513	Belongs to the DEAD box helicase family
BHE83_12305	COG3118	belongs to the thioredoxin family
BHE83_12310	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BHE83_12320	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BHE83_12325	COG0583	DNA-binding transcription factor activity
BHE83_12345	COG1652	LysM domain
BHE83_12350	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BHE83_12350	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BHE83_12355	COG1473	amidohydrolase
BHE83_12360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHE83_12365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BHE83_12375	COG5383	Protein conserved in bacteria
BHE83_12415	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BHE83_12420	COG3023	N-Acetylmuramoyl-L-alanine amidase
BHE83_12430	COG4948	Mandelate Racemase Muconate Lactonizing
BHE83_12440	COG0531	amino acid
BHE83_12455	COG4682	membrane
BHE83_12460	COG2133	pyrroloquinoline quinone binding
BHE83_12470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BHE83_12475	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BHE83_12480	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BHE83_12485	COG1610	YqeY-like protein
BHE83_12490	COG1295	ribonuclease BN
BHE83_12495	COG0358	DNA primase activity
BHE83_12510	COG0109	protoheme IX farnesyltransferase activity
BHE83_12540	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BHE83_12550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BHE83_12590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BHE83_12595	COG0739	heme binding
BHE83_12600	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BHE83_12610	COG2223	nitrite transmembrane transporter activity
BHE83_12615	COG0708	Exodeoxyribonuclease III
BHE83_12620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BHE83_12630	COG1192	Involved in chromosome partitioning
BHE83_12635	COG1475	DNA binding
BHE83_12650	COG0463	Glycosyl transferase, family 2
BHE83_12670	COG0756	dUTP diphosphatase activity
BHE83_12675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BHE83_12680	COG2003	Belongs to the UPF0758 family
BHE83_12685	COG0018	arginyl-trna synthetase
BHE83_12700	COG4221	oxidoreductase activity
BHE83_12725	COG1166	arginine decarboxylase activity
BHE83_12730	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BHE83_12755	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BHE83_12755	COG3291	Pkd domain containing protein
BHE83_12770	COG0606	chelatase, subunit chli
BHE83_12785	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BHE83_12825	COG1690	Belongs to the RtcB family
BHE83_12865	COG1090	epimerase
BHE83_12870	COG0745	RESPONSE REGULATOR receiver
BHE83_12875	COG0642	Histidine kinase
BHE83_12895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BHE83_12915	COG0628	permease
BHE83_12920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BHE83_12925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BHE83_12940	COG0753	catalase activity
BHE83_12955	COG2197	response regulator
BHE83_12960	COG4585	Histidine kinase
BHE83_12965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHE83_12970	COG1136	(ABC) transporter
BHE83_12995	COG0697	spore germination
BHE83_13010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BHE83_13015	COG0180	Tryptophanyl-tRNA synthetase
BHE83_13020	COG3237	CsbD-like
BHE83_13060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BHE83_13080	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BHE83_13085	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BHE83_13085	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BHE83_13110	COG2205	protein histidine kinase activity
BHE83_13115	COG0745	RESPONSE REGULATOR receiver
BHE83_13125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BHE83_13150	COG1199	ATP-dependent helicase activity
BHE83_13165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BHE83_13215	COG0625	glutathione transferase activity
BHE83_13250	COG4555	ABC transporter
BHE83_13260	COG1476	TRANSCRIPTIONal
BHE83_13285	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BHE83_13290	COG1131	(ABC) transporter
BHE83_13295	COG0842	Transport permease protein
BHE83_13300	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BHE83_13325	COG0716	FMN binding
BHE83_13330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BHE83_13335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BHE83_13345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BHE83_13345	COG1042	CoA-binding domain protein
BHE83_13345	COG0045	succinate-CoA ligase (ADP-forming) activity
BHE83_13350	COG2239	Acts as a magnesium transporter
BHE83_13375	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BHE83_13380	COG3387	PFAM Glycoside hydrolase 15-related
BHE83_13390	COG3100	YcgL domain-containing protein
BHE83_13395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BHE83_13405	COG0463	Glycosyl transferase, family 2
BHE83_13415	COG3039	Transposase
BHE83_13430	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_13470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BHE83_13485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BHE83_13520	COG0408	coproporphyrinogen oxidase activity
BHE83_13560	COG0515	serine threonine protein kinase
BHE83_13565	COG0631	protein serine/threonine phosphatase activity
BHE83_13590	COG0667	Aldo Keto reductase
BHE83_13595	COG0583	DNA-binding transcription factor activity
BHE83_13610	COG3501	Rhs element vgr protein
BHE83_13690	COG2963	transposase activity
BHE83_13760	COG0210	DNA helicase
BHE83_13775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BHE83_13780	COG0583	DNA-binding transcription factor activity
BHE83_13785	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BHE83_13795	COG2159	amidohydrolase
BHE83_13800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BHE83_13805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BHE83_13820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHE83_13840	COG0357	Ribosomal RNA small subunit methyltransferase G
BHE83_13845	COG3540	Alkaline phosphatase
BHE83_13855	COG2091	lysine biosynthetic process via aminoadipic acid
BHE83_13875	COG0708	Exodeoxyribonuclease III
BHE83_13885	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BHE83_13890	COG3162	membrane
BHE83_13900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BHE83_13930	COG3507	Belongs to the glycosyl hydrolase 43 family
BHE83_13950	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_13955	COG0179	Fumarylacetoacetate (FAA) hydrolase
BHE83_13960	COG4948	Mandelate Racemase Muconate Lactonizing
BHE83_13965	COG3254	rhamnose metabolic process
BHE83_13970	COG0738	Major facilitator superfamily
BHE83_13975	COG1414	Transcriptional regulator
BHE83_13980	COG1971	Probably functions as a manganese efflux pump
BHE83_13985	COG2205	protein histidine kinase activity
BHE83_13995	COG3459	Glycosyltransferase 36 associated
BHE83_14000	COG2211	Major facilitator Superfamily
BHE83_14005	COG3265	gluconokinase activity
BHE83_14030	COG2911	Protein conserved in bacteria
BHE83_14035	COG0729	surface antigen
BHE83_14050	COG0457	Tetratricopeptide repeat
BHE83_14060	COG0752	glycyl-tRNA synthetase alpha subunit
BHE83_14065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BHE83_14075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BHE83_14075	COG0519	Catalyzes the synthesis of GMP from XMP
BHE83_14085	COG0805	protein transport
BHE83_14090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BHE83_14095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BHE83_14105	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BHE83_14125	COG2974	May be involved in recombination
BHE83_14130	COG0037	tRNA processing
BHE83_14135	COG2115	Belongs to the xylose isomerase family
BHE83_14145	COG3661	Belongs to the glycosyl hydrolase 67 family
BHE83_14155	COG4948	Mandelate Racemase Muconate Lactonizing
BHE83_14165	COG1472	Belongs to the glycosyl hydrolase 3 family
BHE83_14170	COG0246	Mannitol dehydrogenase
BHE83_14215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BHE83_14240	COG3386	PFAM SMP-30 Gluconolaconase
BHE83_14250	COG3250	beta-galactosidase activity
BHE83_14255	COG1904	glucuronate isomerase
BHE83_14260	COG3693	PFAM glycoside hydrolase, family 10
BHE83_14270	COG3693	PFAM glycoside hydrolase, family 10
BHE83_14285	COG2211	Major facilitator Superfamily
BHE83_14320	COG0604	alcohol dehydrogenase
BHE83_14320	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_14320	COG3321	synthase
BHE83_14330	COG2937	Belongs to the GPAT DAPAT family
BHE83_14365	COG0284	orotidine-5'-phosphate decarboxylase activity
BHE83_14370	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BHE83_14375	COG3132	Protein of unknown function, DUF480
BHE83_14390	COG0210	DNA helicase
BHE83_14395	COG1435	thymidine kinase activity
BHE83_14405	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BHE83_14415	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BHE83_14445	COG3135	benzoate transporter
BHE83_14465	COG0676	glucose-6-phosphate 1-epimerase activity
BHE83_14475	COG3012	SEC-C Motif Domain Protein
BHE83_14480	COG0730	response to heat
BHE83_14500	COG0302	gtp cyclohydrolase
BHE83_14515	COG1566	PFAM secretion protein HlyD family protein
BHE83_14525	COG1289	transmembrane transporter activity
BHE83_14530	COG0477	Major facilitator Superfamily
BHE83_14550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BHE83_14620	COG0564	pseudouridine synthase activity
BHE83_14655	COG1309	transcriptional regulator
BHE83_14665	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_14705	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BHE83_14710	COG1074	ATP-dependent DNA helicase activity
BHE83_14715	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BHE83_14750	COG1127	ABC transporter
BHE83_14755	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BHE83_14760	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BHE83_14775	COG2853	Lipoprotein
BHE83_14785	COG0386	Belongs to the glutathione peroxidase family
BHE83_14795	COG1322	Protein conserved in bacteria
BHE83_14800	COG0604	alcohol dehydrogenase
BHE83_14805	COG0583	DNA-binding transcription factor activity
BHE83_14825	COG0531	amino acid
BHE83_14830	COG3537	Alpha-1,2-mannosidase
BHE83_14835	COG4206	TonB-dependent receptor
BHE83_14845	COG3706	GGDEF domain
BHE83_14850	COG3835	regulator
BHE83_14855	COG1929	Belongs to the glycerate kinase type-1 family
BHE83_14860	COG2271	Major facilitator Superfamily
BHE83_14875	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BHE83_14880	COG0861	Integral membrane protein TerC family
BHE83_14890	COG0584	glycerophosphoryl diester phosphodiesterase
BHE83_14910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BHE83_14915	COG0726	polysaccharide deacetylase
BHE83_14920	COG0706	membrane insertase activity
BHE83_14925	COG0594	ribonuclease P activity
BHE83_14930	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BHE83_14935	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BHE83_14945	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BHE83_14950	COG0187	DNA topoisomerase II activity
BHE83_14960	COG0501	Belongs to the peptidase M48B family
BHE83_15000	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BHE83_15010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BHE83_15050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BHE83_15055	COG0793	Belongs to the peptidase S41A family
BHE83_15060	COG4942	peptidase
BHE83_15070	COG2234	aminopeptidase activity
BHE83_15080	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BHE83_15085	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BHE83_15095	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BHE83_15100	COG1064	alcohol dehydrogenase
BHE83_15105	COG0493	'glutamate synthase
BHE83_15110	COG0070	glutamate synthase
BHE83_15110	COG0069	glutamate synthase activity
BHE83_15110	COG0067	glutamate synthase
BHE83_15195	COG1205	dead DEAH box helicase
BHE83_15195	COG1111	helicase
BHE83_15200	COG1272	protein, Hemolysin III
BHE83_15220	COG0300	oxidoreductase activity
BHE83_15225	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_15230	COG0515	serine threonine protein kinase
BHE83_15230	COG2815	serine threonine protein kinase
BHE83_15240	COG2963	transposase activity
BHE83_15265	COG3237	CsbD-like
BHE83_15315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BHE83_15320	COG0477	Major facilitator Superfamily
BHE83_15360	COG0714	Associated with various cellular activities
BHE83_15405	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BHE83_15425	COG4772	TonB-dependent receptor
BHE83_15445	COG1012	belongs to the aldehyde dehydrogenase family
BHE83_15470	COG1304	FMN binding
BHE83_15485	COG1755	Isoprenylcysteine carboxyl methyltransferase
BHE83_15490	COG4585	Histidine kinase
BHE83_15495	COG2197	response regulator
BHE83_15515	COG3710	Transcriptional regulator
BHE83_15520	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BHE83_15530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BHE83_15550	COG2963	transposase activity
BHE83_15560	COG3039	Transposase
BHE83_15600	COG0366	Alpha amylase catalytic
BHE83_15605	COG0366	Alpha amylase catalytic
BHE83_15610	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BHE83_15625	COG2272	Belongs to the type-B carboxylesterase lipase family
BHE83_15630	COG2755	lipolytic protein G-D-S-L family
BHE83_15630	COG0657	acetylesterase activity
BHE83_15640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BHE83_15655	COG3507	Belongs to the glycosyl hydrolase 43 family
BHE83_15660	COG1609	Transcriptional regulator
BHE83_15665	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BHE83_15670	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_15680	COG2755	lipolytic protein G-D-S-L family
BHE83_15690	COG3186	Phenylalanine-4-hydroxylase
BHE83_15695	COG1522	sequence-specific DNA binding
BHE83_15705	COG1752	Esterase of the alpha-beta hydrolase superfamily
BHE83_15710	COG1473	amidohydrolase
BHE83_15720	COG1119	ATPase activity
BHE83_15735	COG1125	glycine betaine transport
BHE83_15750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BHE83_15780	COG0489	protein tyrosine kinase activity
BHE83_15785	COG2062	phosphohistidine phosphatase, SixA
BHE83_15795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BHE83_15840	COG1968	undecaprenyl-diphosphatase activity
BHE83_15845	COG0174	glutamine synthetase
BHE83_15850	COG0347	Belongs to the P(II) protein family
BHE83_15855	COG0004	ammonium transporteR
BHE83_15860	COG3852	Histidine kinase
BHE83_15865	COG2204	response regulator
BHE83_15870	COG2032	superoxide dismutase activity
BHE83_15875	COG2032	superoxide dismutase activity
BHE83_15880	COG0346	lactoylglutathione lyase activity
BHE83_15890	COG0183	Belongs to the thiolase family
BHE83_15925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BHE83_15930	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BHE83_15935	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BHE83_16030	COG2963	transposase activity
BHE83_16070	COG0028	Belongs to the TPP enzyme family
BHE83_16075	COG4191	Histidine kinase
BHE83_16100	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BHE83_16115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BHE83_16120	COG3177	Filamentation induced by cAMP protein fic
BHE83_16125	COG0596	Alpha beta hydrolase
BHE83_16135	COG0318	PFAM AMP-dependent synthetase and ligase
BHE83_16140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BHE83_16150	COG1181	Belongs to the D-alanine--D-alanine ligase family
BHE83_16165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BHE83_16175	COG0564	pseudouridine synthase activity
BHE83_16195	COG1446	asparaginase
BHE83_16200	COG0339	signal peptide processing
BHE83_16235	COG0475	glutathione-regulated potassium exporter activity
BHE83_16240	COG0583	DNA-binding transcription factor activity
BHE83_16245	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BHE83_16250	COG2224	Isocitrate lyase
BHE83_16255	COG3706	GGDEF domain
BHE83_16285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BHE83_16290	COG1960	acyl-CoA dehydrogenase activity
BHE83_16350	COG0523	cobalamin synthesis protein
BHE83_16365	COG0697	spore germination
BHE83_16375	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BHE83_16380	COG1846	Transcriptional regulator
BHE83_16385	COG1764	response to oxidative stress
BHE83_16405	COG2130	NADP-dependent
BHE83_16420	COG1187	pseudouridine synthase activity
BHE83_16430	COG1643	Atp-dependent helicase
BHE83_16440	COG4807	Protein conserved in bacteria
BHE83_16445	COG2351	hydroxyisourate hydrolase activity
BHE83_16450	COG2072	flavoprotein involved in K transport
BHE83_16470	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BHE83_16485	COG0583	DNA-binding transcription factor activity
BHE83_16525	COG2252	PERMEase
BHE83_16545	COG0084	hydrolase, TatD family'
BHE83_16560	COG0583	DNA-binding transcription factor activity
BHE83_16565	COG2814	Major facilitator Superfamily
BHE83_16575	COG2267	carboxylic ester hydrolase activity
BHE83_16580	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BHE83_16585	COG1902	pentaerythritol trinitrate reductase activity
BHE83_16605	COG0745	RESPONSE REGULATOR receiver
BHE83_16610	COG2205	protein histidine kinase activity
BHE83_16615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHE83_16625	COG1538	Outer membrane efflux protein
BHE83_16640	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BHE83_16645	COG0583	DNA-binding transcription factor activity
BHE83_16660	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BHE83_16680	COG0702	epimerase
BHE83_16685	COG1733	regulation of RNA biosynthetic process
BHE83_16710	COG2801	Transposase and inactivated derivatives
BHE83_16730	COG0129	dihydroxy-acid dehydratase activity
BHE83_16750	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BHE83_16805	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BHE83_16810	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BHE83_16835	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BHE83_16840	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BHE83_16850	COG3485	protocatechuate 3,4-dioxygenase
BHE83_16855	COG3485	protocatechuate 3,4-dioxygenase
BHE83_16865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BHE83_16870	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BHE83_16885	COG1414	Transcriptional regulator
BHE83_16905	COG0445	tRNA wobble uridine modification
BHE83_16915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BHE83_16940	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_16945	COG2267	carboxylic ester hydrolase activity
BHE83_16955	COG0156	8-amino-7-oxononanoate synthase activity
BHE83_16960	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BHE83_16965	COG1040	competence protein
BHE83_16970	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BHE83_17070	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BHE83_17130	COG2963	transposase activity
BHE83_17160	COG3264	Mechanosensitive ion channel
BHE83_17160	COG1511	domain protein
BHE83_17165	COG1368	sulfuric ester hydrolase activity
BHE83_17170	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BHE83_17175	COG2354	Protein conserved in bacteria
BHE83_17180	COG0745	RESPONSE REGULATOR receiver
BHE83_17180	COG3706	GGDEF domain
BHE83_17185	COG0297	glycogen (starch) synthase activity
BHE83_17190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BHE83_17195	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BHE83_17220	COG0702	epimerase
BHE83_17225	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_17255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BHE83_17260	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_17270	COG0513	Belongs to the DEAD box helicase family
BHE83_17280	COG0508	dehydrogenase complex catalyzes the overall conversion of
BHE83_17295	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BHE83_17305	COG3483	tryptophan 2,3-dioxygenase activity
BHE83_17310	COG3104	oligopeptide transport
BHE83_17330	COG2852	Protein conserved in bacteria
BHE83_17335	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BHE83_17355	COG1320	monovalent cation:proton antiporter activity
BHE83_17360	COG2212	antiporter activity
BHE83_17365	COG1863	multisubunit Na H antiporter MnhE subunit
BHE83_17370	COG0651	ATP synthesis coupled electron transport
BHE83_17375	COG1006	Multisubunit Na H antiporter MnhC subunit
BHE83_17380	COG2111	Na H antiporter
BHE83_17380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BHE83_17400	COG3179	chitinase
BHE83_17420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BHE83_17425	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BHE83_17435	COG0456	acetyltransferase
BHE83_17440	COG1597	lipid kinase activity
BHE83_17460	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BHE83_17495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BHE83_17500	COG0134	indole-3-glycerol-phosphate synthase activity
BHE83_17510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BHE83_17515	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BHE83_17525	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BHE83_17530	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BHE83_17535	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BHE83_17550	COG1051	belongs to the nudix hydrolase family
BHE83_17590	COG0316	Belongs to the HesB IscA family
BHE83_17605	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BHE83_17630	COG2814	Major facilitator Superfamily
BHE83_17635	COG1289	transmembrane transporter activity
BHE83_17640	COG0151	Belongs to the GarS family
BHE83_17650	COG0138	bifunctional purine biosynthesis protein purh
BHE83_17655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BHE83_17660	COG2267	carboxylic ester hydrolase activity
BHE83_17665	COG0671	phosphoesterase, PA-phosphatase related
BHE83_17665	COG2453	phosphatase
BHE83_17690	COG4589	Belongs to the CDS family
BHE83_17695	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BHE83_17720	COG2264	protein methyltransferase activity
BHE83_17740	COG0439	Biotin carboxylase
BHE83_17750	COG0511	ligase activity, forming carbon-carbon bonds
BHE83_17755	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BHE83_17765	COG1324	tolerance protein
BHE83_17775	COG2356	endonuclease I
BHE83_17785	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BHE83_17790	COG0459	protein refolding
BHE83_17805	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BHE83_17830	COG3386	PFAM SMP-30 Gluconolaconase
BHE83_17840	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BHE83_17880	COG0778	Nitroreductase
BHE83_17885	COG2353	YceI-like domain
BHE83_17920	COG3052	prosthetic group binding
BHE83_17940	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
BHE83_17945	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BHE83_17955	COG1802	Transcriptional regulator
BHE83_17960	COG0546	phosphoglycolate phosphatase activity
BHE83_18000	COG0464	growth
BHE83_18030	COG2963	transposase activity
BHE83_18045	COG3039	Transposase
BHE83_18060	COG4221	oxidoreductase activity
BHE83_18070	COG2963	transposase activity
BHE83_18115	COG4221	oxidoreductase activity
BHE83_18125	COG0435	Glutathione S-transferase
BHE83_18170	COG3706	GGDEF domain
BHE83_18175	COG1959	2 iron, 2 sulfur cluster binding
BHE83_18200	COG0697	spore germination
BHE83_18215	COG1113	amino acid transport
BHE83_18225	COG0598	Magnesium transport protein CorA
BHE83_18235	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
BHE83_18270	COG0840	transmembrane signaling receptor activity
BHE83_18275	COG5297	Belongs to the glycosyl hydrolase family 6
BHE83_18275	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BHE83_18280	COG0659	secondary active sulfate transmembrane transporter activity
BHE83_18285	COG3706	GGDEF domain
BHE83_18295	COG2943	transferase activity, transferring hexosyl groups
BHE83_18305	COG3275	phosphorelay sensor kinase activity
BHE83_18315	COG0181	hydroxymethylbilane synthase activity
BHE83_18350	COG1505	serine-type exopeptidase activity
BHE83_18365	COG2832	Protein of unknown function (DUF454)
BHE83_18375	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BHE83_18385	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BHE83_18390	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BHE83_18395	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BHE83_18425	COG5001	Diguanylate cyclase
BHE83_18425	COG3300	MHYT domain
BHE83_18430	COG0308	aminopeptidase N
BHE83_18455	COG2801	Transposase and inactivated derivatives
BHE83_18490	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BHE83_18500	COG3284	Transcriptional regulator
BHE83_18510	COG1077	Cell shape determining protein MreB Mrl
BHE83_18515	COG1792	Involved in formation and maintenance of cell shape
BHE83_18530	COG0772	Belongs to the SEDS family
BHE83_18540	COG2951	lytic endotransglycosylase activity
BHE83_18545	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BHE83_18550	COG1686	Belongs to the peptidase S11 family
BHE83_18560	COG2921	Belongs to the UPF0250 family
BHE83_18565	COG0321	lipoyl(octanoyl) transferase activity
BHE83_18570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BHE83_18585	COG0583	DNA-binding transcription factor activity
BHE83_18595	COG1051	belongs to the nudix hydrolase family
BHE83_18595	COG1056	cytidyltransferase-related domain
BHE83_18630	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BHE83_18635	COG0673	inositol 2-dehydrogenase activity
BHE83_18640	COG2823	Periplasmic or secreted lipoprotein
BHE83_18645	COG4251	negative regulation of phosphorylation
BHE83_18650	COG0784	Response regulator, receiver
BHE83_18655	COG4191	Histidine kinase
BHE83_18660	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BHE83_18715	COG1459	type II secretion system
BHE83_18735	COG4795	General secretion pathway protein
BHE83_18770	COG1609	Transcriptional regulator
BHE83_18775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BHE83_18780	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BHE83_18795	COG0617	tRNA 3'-terminal CCA addition
BHE83_18800	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BHE83_18805	COG1012	belongs to the aldehyde dehydrogenase family
BHE83_18810	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BHE83_18840	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BHE83_18850	COG2205	protein histidine kinase activity
BHE83_18855	COG0745	RESPONSE REGULATOR receiver
BHE83_18880	COG3791	Glutathione-dependent formaldehyde-activating
BHE83_18885	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BHE83_18895	COG0488	(ABC) transporter
BHE83_18905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BHE83_18915	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BHE83_18925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BHE83_18925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BHE83_18945	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BHE83_18950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BHE83_18955	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BHE83_18975	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BHE83_18980	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BHE83_18990	COG2205	protein histidine kinase activity
BHE83_18995	COG0745	RESPONSE REGULATOR receiver
BHE83_19005	COG0277	FAD linked oxidase domain protein
BHE83_19010	COG1988	membrane-bound metal-dependent
BHE83_19015	COG0792	nuclease activity
BHE83_19050	COG2001	Belongs to the MraZ family
BHE83_19055	COG0275	rRNA processing
BHE83_19060	COG3116	cell division
BHE83_19075	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BHE83_19080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BHE83_19085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BHE83_19095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BHE83_19100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BHE83_19105	COG1181	Belongs to the D-alanine--D-alanine ligase family
BHE83_19110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BHE83_19125	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BHE83_19135	COG0739	heme binding
BHE83_19140	COG0653	protein targeting
BHE83_19145	COG0494	nUDIX hydrolase
BHE83_19155	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BHE83_19165	COG0604	alcohol dehydrogenase
BHE83_19165	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_19165	COG3321	synthase
BHE83_19220	COG2226	methyltransferase
BHE83_19225	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BHE83_19235	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BHE83_19275	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BHE83_19285	COG4106	trans-aconitate 2-methyltransferase activity
BHE83_19290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BHE83_19300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BHE83_19305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BHE83_19310	COG0667	Aldo Keto reductase
BHE83_19320	COG4771	TonB-dependent receptor
BHE83_19340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BHE83_19345	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BHE83_19355	COG2175	clavaminate synthase activity
BHE83_19365	COG4181	ATPase activity
BHE83_19380	COG0642	Histidine kinase
BHE83_19390	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BHE83_19410	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BHE83_19415	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BHE83_19430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BHE83_19435	COG2967	ApaG domain
BHE83_19440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BHE83_19445	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BHE83_19450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BHE83_19455	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BHE83_19460	COG0123	including yeast histone deacetylase and acetoin utilization protein
BHE83_19465	COG2096	Adenosyltransferase
BHE83_19475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BHE83_19480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BHE83_19510	COG3384	dioxygenase
BHE83_19515	COG0583	DNA-binding transcription factor activity
BHE83_19520	COG0318	PFAM AMP-dependent synthetase and ligase
BHE83_19530	COG1024	Enoyl-CoA hydratase
BHE83_19550	COG3386	PFAM SMP-30 Gluconolaconase
BHE83_19560	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BHE83_19590	COG0697	spore germination
BHE83_19600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BHE83_19615	COG3706	GGDEF domain
BHE83_19615	COG0745	RESPONSE REGULATOR receiver
BHE83_19625	COG2197	response regulator
BHE83_19635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BHE83_19645	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BHE83_19650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BHE83_19655	COG0583	DNA-binding transcription factor activity
BHE83_19660	COG3634	alkyl hydroperoxide reductase activity
BHE83_19670	COG2890	protein-(glutamine-N5) methyltransferase activity
BHE83_19690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BHE83_19690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BHE83_19705	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BHE83_19725	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BHE83_19730	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BHE83_19745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BHE83_19750	COG1404	Belongs to the peptidase S8 family
BHE83_19755	COG1404	Belongs to the peptidase S8 family
BHE83_19760	COG1404	Belongs to the peptidase S8 family
BHE83_19765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BHE83_19790	COG1295	ribonuclease BN
BHE83_19795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BHE83_19800	COG1254	Belongs to the acylphosphatase family
BHE83_19815	COG0521	Mo-molybdopterin cofactor biosynthetic process
BHE83_19825	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BHE83_19830	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BHE83_19840	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BHE83_19845	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BHE83_19855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BHE83_19860	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BHE83_19865	COG0193	aminoacyl-tRNA hydrolase activity
BHE83_19870	COG0012	GTP binding
BHE83_19890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BHE83_19900	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BHE83_19905	COG0250	Participates in transcription elongation, termination and antitermination
BHE83_19910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BHE83_19915	COG0081	regulation of translation
BHE83_19920	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BHE83_19925	COG0222	ribosome binding
BHE83_19930	COG0085	RNA polymerase activity
BHE83_19935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BHE83_19940	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BHE83_19945	COG0049	tRNA binding
BHE83_19950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BHE83_19955	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BHE83_19965	COG0051	transcription antitermination factor activity, RNA binding
BHE83_19970	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BHE83_19975	COG0088	Forms part of the polypeptide exit tunnel
BHE83_19980	COG0089	rRNA binding
BHE83_19985	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BHE83_19990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BHE83_19995	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BHE83_20000	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BHE83_20005	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BHE83_20010	COG0255	Belongs to the universal ribosomal protein uL29 family
BHE83_20015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BHE83_20020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BHE83_20025	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BHE83_20030	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BHE83_20035	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BHE83_20040	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BHE83_20045	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BHE83_20050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BHE83_20055	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BHE83_20060	COG1841	ribosomal large subunit assembly
BHE83_20065	COG0200	Binds to the 23S rRNA
BHE83_20070	COG0201	protein transport
BHE83_20075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BHE83_20080	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BHE83_20085	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BHE83_20090	COG0202	RNA polymerase activity
BHE83_20095	COG0203	ribosomal protein L17
BHE83_20100	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BHE83_20115	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BHE83_20125	COG0154	amidase activity
BHE83_20140	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BHE83_20145	COG0039	L-malate dehydrogenase activity
BHE83_20150	COG0625	glutathione transferase activity
BHE83_20160	COG1902	pentaerythritol trinitrate reductase activity
BHE83_20160	COG0446	pyridine nucleotide-disulphide oxidoreductase
BHE83_20170	COG2885	chlorophyll binding
BHE83_20190	COG0156	8-amino-7-oxononanoate synthase activity
BHE83_20195	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BHE83_20200	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BHE83_20205	COG4208	sulfate ABC transporter
BHE83_20210	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BHE83_20220	COG1063	alcohol dehydrogenase
BHE83_20240	COG0406	alpha-ribazole phosphatase activity
BHE83_20245	COG0285	dihydrofolate synthase activity
BHE83_20265	COG2833	Protein of unknown function (DUF455)
BHE83_20270	COG3291	Pkd domain containing protein
BHE83_20280	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BHE83_20285	COG0671	phosphoesterase, PA-phosphatase related
BHE83_20290	COG0438	transferase activity, transferring glycosyl groups
BHE83_20300	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BHE83_20315	COG4783	chaperone-mediated protein folding
BHE83_20330	COG0473	3-isopropylmalate dehydrogenase activity
BHE83_20360	COG3852	Histidine kinase
BHE83_20370	COG0544	peptidyl-prolyl cis-trans isomerase activity
BHE83_20375	COG0740	serine-type endopeptidase activity
BHE83_20380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BHE83_20410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BHE83_20420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BHE83_20430	COG0328	RNA-DNA hybrid ribonuclease activity
BHE83_20435	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BHE83_20440	COG0631	protein serine/threonine phosphatase activity
BHE83_20470	COG2963	transposase activity
BHE83_20495	COG0859	PFAM glycosyl transferase family 9
BHE83_20500	COG3642	lipopolysaccharide core region biosynthetic process
BHE83_20505	COG1234	tRNA 3'-trailer cleavage
BHE83_20510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BHE83_20520	COG0315	cyclic pyranopterin monophosphate synthase activity
BHE83_20525	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BHE83_20530	COG0314	molybdopterin synthase activity
BHE83_20560	COG2963	transposase activity
BHE83_20565	COG2801	Transposase and inactivated derivatives
BHE83_20590	COG2801	Transposase and inactivated derivatives
BHE83_20600	COG0322	excinuclease ABC activity
BHE83_20640	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BHE83_20645	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BHE83_20650	COG0537	adenosine 5'-monophosphoramidase activity
BHE83_20670	COG0714	Associated with various cellular activities
BHE83_20685	COG2963	transposase activity
BHE83_20690	COG2801	Transposase and inactivated derivatives
BHE83_20705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BHE83_20710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BHE83_20730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BHE83_20740	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BHE83_20745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BHE83_20775	COG3829	transcription factor binding
BHE83_20800	COG2828	Protein conserved in bacteria
BHE83_20815	COG2373	Large extracellular alpha-helical protein
BHE83_20830	COG4953	penicillin-binding protein 1C
BHE83_20860	COG0330	HflC and HflK could
BHE83_20865	COG0330	HflC and HflK could
BHE83_20875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BHE83_20880	COG0308	aminopeptidase N
BHE83_20890	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_20895	COG1309	transcriptional regulator
BHE83_20940	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BHE83_20950	COG0732	type I restriction modification DNA specificity domain
BHE83_20955	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BHE83_20980	COG0406	alpha-ribazole phosphatase activity
BHE83_20980	COG0328	RNA-DNA hybrid ribonuclease activity
BHE83_20985	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BHE83_20995	COG3387	PFAM Glycoside hydrolase 15-related
BHE83_21000	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_21005	COG3537	Alpha-1,2-mannosidase
BHE83_21015	COG1028	Short-chain dehydrogenase reductase Sdr
BHE83_21025	COG0492	ferredoxin-NADP+ reductase activity
BHE83_21050	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BHE83_21055	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BHE83_21060	COG2080	2 iron, 2 sulfur cluster binding
BHE83_21095	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BHE83_21115	COG0587	DNA-directed DNA polymerase activity
BHE83_21130	COG1297	OPT oligopeptide transporter protein
BHE83_21145	COG0823	Involved in the tonB-independent uptake of proteins
BHE83_21145	COG1506	peptidase
BHE83_21160	COG1917	Cupin 2, conserved barrel domain protein
BHE83_21160	COG2207	Transcriptional regulator
BHE83_21180	COG0753	catalase activity
BHE83_21185	COG0656	L-ascorbic acid biosynthetic process
BHE83_21190	COG2272	Belongs to the type-B carboxylesterase lipase family
BHE83_21195	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BHE83_21195	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BHE83_21220	COG2814	Major facilitator Superfamily
BHE83_21240	COG2194	sulfuric ester hydrolase activity
BHE83_21255	COG0745	RESPONSE REGULATOR receiver
BHE83_21260	COG0642	Histidine kinase
BHE83_21270	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BHE83_21275	COG2894	cell division
BHE83_21280	COG0850	regulation of cytokinetic process
BHE83_21290	COG4585	Histidine kinase
BHE83_21295	COG2197	response regulator
BHE83_21310	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BHE83_21335	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BHE83_21350	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BHE83_21365	COG1595	DNA-templated transcription, initiation
BHE83_21380	COG1024	Enoyl-CoA hydratase
BHE83_21390	COG0824	Thioesterase
BHE83_21395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BHE83_21400	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BHE83_21405	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BHE83_21410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BHE83_21415	COG0268	Binds directly to 16S ribosomal RNA
BHE83_21425	COG0196	riboflavin kinase activity
BHE83_21430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BHE83_21435	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BHE83_21440	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BHE83_21455	COG3039	Transposase
BHE83_21490	COG2963	transposase activity
BHE83_21530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BHE83_21535	COG1845	cytochrome c oxidase, subunit III
BHE83_21540	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BHE83_21555	COG3152	Membrane
BHE83_21565	COG2207	Transcriptional regulator
BHE83_21570	COG0326	Molecular chaperone. Has ATPase activity
BHE83_21580	COG1366	Belongs to the anti-sigma-factor antagonist family
BHE83_21585	COG1366	Belongs to the anti-sigma-factor antagonist family
BHE83_21590	COG2172	sigma factor antagonist activity
BHE83_21615	COG4771	TonB-dependent receptor
BHE83_21625	COG5507	3-demethylubiquinone-9 3-methyltransferase
BHE83_21630	COG2205	protein histidine kinase activity
BHE83_21640	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BHE83_21645	COG2205	protein histidine kinase activity
BHE83_21645	COG3437	response regulator, receiver
BHE83_21645	COG4999	Histidine kinase
BHE83_21645	COG3850	Histidine kinase
BHE83_21650	COG0784	Response regulator, receiver
BHE83_21650	COG4191	Histidine kinase
BHE83_21675	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BHE83_21680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BHE83_21690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BHE83_21695	COG0228	four-way junction DNA binding
BHE83_21700	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BHE83_21705	COG0336	Belongs to the RNA methyltransferase TrmD family
BHE83_21710	COG0335	large ribosomal subunit rRNA binding
BHE83_21740	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BHE83_21750	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BHE83_21765	COG2801	Transposase and inactivated derivatives
BHE83_21770	COG2963	transposase activity
BHE83_21785	COG3250	beta-galactosidase activity
BHE83_21790	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BHE83_21810	COG1960	acyl-CoA dehydrogenase activity
BHE83_21815	COG1024	Enoyl-CoA hydratase
BHE83_21835	COG1024	Enoyl-CoA hydratase
BHE83_21835	COG1250	3-hydroxyacyl-CoA dehydrogenase
BHE83_21850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BHE83_21855	COG0481	GTPase activity
BHE83_21870	COG0571	ribonuclease III activity
BHE83_21875	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BHE83_21885	COG1381	Involved in DNA repair and RecF pathway recombination
BHE83_21900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BHE83_21910	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BHE83_21915	COG1233	COG1233 Phytoene dehydrogenase and related
BHE83_21920	COG3046	protein related to deoxyribodipyrimidine photolyase
BHE83_21925	COG1472	Belongs to the glycosyl hydrolase 3 family
BHE83_21935	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BHE83_21940	COG1278	Cold shock
BHE83_21955	COG1201	RNA secondary structure unwinding
BHE83_21960	COG1793	dna ligase
BHE83_21970	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BHE83_21970	COG1793	dna ligase
BHE83_21990	COG3706	GGDEF domain
BHE83_21990	COG0745	RESPONSE REGULATOR receiver
BHE83_22005	COG0183	Belongs to the thiolase family
BHE83_22030	COG1451	nucleotide metabolic process
BHE83_22035	COG5487	UPF0391 membrane protein
BHE83_22045	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BHE83_22065	COG1077	Cell shape determining protein MreB Mrl
BHE83_22080	COG2824	Alkylphosphonate utilization operon protein PhnA
BHE83_22085	COG1902	pentaerythritol trinitrate reductase activity
BHE83_22090	COG2814	Major facilitator Superfamily
BHE83_22125	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BHE83_22125	COG0392	lysyltransferase activity
BHE83_22135	COG0251	oxidation-reduction process
BHE83_22140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BHE83_22155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BHE83_22180	COG1595	DNA-templated transcription, initiation
BHE83_22200	COG2878	Part of a membrane complex involved in electron transport
BHE83_22210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BHE83_22210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BHE83_22230	COG0346	lactoylglutathione lyase activity
BHE83_22245	COG0833	amino acid
BHE83_22250	COG2040	homocysteine
BHE83_22260	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BHE83_22280	COG1695	Transcriptional regulator
BHE83_22315	COG0825	malonyl-CoA metabolic process
BHE83_22320	COG0587	DNA-directed DNA polymerase activity
BHE83_22330	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BHE83_22335	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BHE83_22340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BHE83_22345	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BHE83_22360	COG0750	zinc metalloprotease
BHE83_22395	COG0305	Participates in initiation and elongation during chromosome replication
BHE83_22465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BHE83_22465	COG1754	DNA topoisomerase type I activity
BHE83_22525	COG3039	Transposase
BHE83_22530	COG2963	transposase activity
BHE83_22545	COG2963	transposase activity
BHE83_22550	COG2801	Transposase and inactivated derivatives
BHE83_22555	COG3039	Transposase
BHE83_22590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BHE83_22650	COG1475	DNA binding
BHE83_22655	COG1192	Involved in chromosome partitioning
BHE83_22765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BHE83_22770	COG3287	FIST C domain
BHE83_22770	COG2200	EAL domain
BHE83_22770	COG2199	diguanylate cyclase activity
BHE83_22840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BHE83_22850	COG2974	May be involved in recombination
BHE83_22880	COG0776	regulation of translation
BHE83_22885	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BHE83_22950	COG3318	Belongs to the UPF0149 family
BHE83_22950	COG3012	SEC-C Motif Domain Protein
BHE83_22970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BHE83_22990	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BHE83_22995	COG4456	Virulence-associated protein
BHE83_23055	COG2963	transposase activity
BHE83_23105	COG0210	DNA helicase
BHE83_23130	COG0464	growth
BHE83_23145	COG0653	protein targeting
BHE83_23265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BHE83_23355	COG3328	transposase activity
BHE83_23395	COG2337	Toxic component of a toxin-antitoxin (TA) module
BHE83_23430	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BHE83_23450	COG3012	SEC-C Motif Domain Protein
BHE83_23450	COG3318	Belongs to the UPF0149 family
BHE83_23470	COG3704	protein secretion by the type IV secretion system
BHE83_23480	COG3504	Conjugal transfer protein
BHE83_23545	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BHE83_23570	COG2963	transposase activity
BHE83_23585	COG2801	Transposase and inactivated derivatives