locus-tag	class	description
XCV0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XCV0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XCV0004	COG0187	DNA topoisomerase II activity
XCV0006	COG0501	Belongs to the peptidase M48B family
XCV0013	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XCV0015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCV0023	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XCV0024	COG0793	Belongs to the peptidase S41A family
XCV0025	COG4942	peptidase
XCV0027	COG2234	aminopeptidase activity
XCV0029	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCV0031	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCV0033	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCV0034	COG1064	alcohol dehydrogenase
XCV0036	COG0493	'glutamate synthase
XCV0037	COG0069	glutamate synthase activity
XCV0037	COG0070	glutamate synthase
XCV0037	COG0067	glutamate synthase
XCV0042	COG2366	antibiotic biosynthetic process
XCV0055	COG1111	helicase
XCV0055	COG1205	dead DEAH box helicase
XCV0056	COG1272	protein, Hemolysin III
XCV0059	COG0300	oxidoreductase activity
XCV0060	COG1028	Short-chain dehydrogenase reductase Sdr
XCV0063	COG2815	serine threonine protein kinase
XCV0063	COG0515	serine threonine protein kinase
XCV0065	COG2963	transposase activity
XCV0071	COG3237	CsbD-like
XCV0080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XCV0081	COG0477	Major facilitator Superfamily
XCV0089	COG0714	Associated with various cellular activities
XCV0098	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XCV0102	COG4772	TonB-dependent receptor
XCV0105	COG1012	belongs to the aldehyde dehydrogenase family
XCV0110	COG1304	FMN binding
XCV0113	COG1755	Isoprenylcysteine carboxyl methyltransferase
XCV0114	COG4585	Histidine kinase
XCV0115	COG2197	response regulator
XCV0119	COG3710	Transcriptional regulator
XCV0120	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XCV0122	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XCV0126	COG2963	transposase activity
XCV0129	COG3039	Transposase
XCV0139	COG0366	Alpha amylase catalytic
XCV0140	COG0366	Alpha amylase catalytic
XCV0141	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XCV0144	COG2272	Belongs to the type-B carboxylesterase lipase family
XCV0145	COG2755	lipolytic protein G-D-S-L family
XCV0145	COG0657	acetylesterase activity
XCV0147	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XCV0150	COG3507	Belongs to the glycosyl hydrolase 43 family
XCV0151	COG1609	Transcriptional regulator
XCV0152	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
XCV0153	COG1028	Short-chain dehydrogenase reductase Sdr
XCV0155	COG2755	lipolytic protein G-D-S-L family
XCV0157	COG3186	Phenylalanine-4-hydroxylase
XCV0158	COG1522	sequence-specific DNA binding
XCV0160	COG1752	Esterase of the alpha-beta hydrolase superfamily
XCV0161	COG1473	amidohydrolase
XCV0163	COG1119	ATPase activity
XCV0166	COG1125	glycine betaine transport
XCV0169	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XCV0175	COG0489	protein tyrosine kinase activity
XCV0176	COG2062	phosphohistidine phosphatase, SixA
XCV0178	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCV0187	COG1968	undecaprenyl-diphosphatase activity
XCV0188	COG0174	glutamine synthetase
XCV0189	COG0347	Belongs to the P(II) protein family
XCV0190	COG0004	ammonium transporteR
XCV0191	COG3852	Histidine kinase
XCV0192	COG2204	response regulator
XCV0193	COG2032	superoxide dismutase activity
XCV0194	COG2032	superoxide dismutase activity
XCV0196	COG0346	lactoylglutathione lyase activity
XCV0198	COG0183	Belongs to the thiolase family
XCV0205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XCV0206	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XCV0207	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XCV0223	COG2963	transposase activity
XCV0230	COG0028	Belongs to the TPP enzyme family
XCV0231	COG4191	Histidine kinase
XCV0236	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XCV0239	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XCV0240	COG3177	Filamentation induced by cAMP protein fic
XCV0241	COG0596	Alpha beta hydrolase
XCV0243	COG0318	PFAM AMP-dependent synthetase and ligase
XCV0244	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XCV0246	COG1181	Belongs to the D-alanine--D-alanine ligase family
XCV0248	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XCV0250	COG0564	pseudouridine synthase activity
XCV0254	COG1446	asparaginase
XCV0255	COG0339	signal peptide processing
XCV0261	COG0475	glutathione-regulated potassium exporter activity
XCV0263	COG0583	DNA-binding transcription factor activity
XCV0264	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XCV0265	COG2224	Isocitrate lyase
XCV0266	COG3706	GGDEF domain
XCV0272	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XCV0273	COG1960	acyl-CoA dehydrogenase activity
XCV0284	COG0523	cobalamin synthesis protein
XCV0286	COG0697	spore germination
XCV0288	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XCV0289	COG1846	Transcriptional regulator
XCV0290	COG1764	response to oxidative stress
XCV0295	COG2130	NADP-dependent
XCV0298	COG1187	pseudouridine synthase activity
XCV0300	COG1643	Atp-dependent helicase
XCV0302	COG4807	Protein conserved in bacteria
XCV0303	COG2351	hydroxyisourate hydrolase activity
XCV0304	COG2072	flavoprotein involved in K transport
XCV0308	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XCV0311	COG0583	DNA-binding transcription factor activity
XCV0318	COG2252	PERMEase
XCV0322	COG0084	hydrolase, TatD family'
XCV0325	COG0583	DNA-binding transcription factor activity
XCV0326	COG2814	Major facilitator Superfamily
XCV0328	COG2267	carboxylic ester hydrolase activity
XCV0329	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XCV0330	COG1902	pentaerythritol trinitrate reductase activity
XCV0334	COG0745	RESPONSE REGULATOR receiver
XCV0335	COG2205	protein histidine kinase activity
XCV0336	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCV0338	COG1538	Outer membrane efflux protein
XCV0341	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XCV0342	COG0583	DNA-binding transcription factor activity
XCV0345	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
XCV0349	COG0702	epimerase
XCV0350	COG1733	regulation of RNA biosynthetic process
XCV0354	COG2801	Transposase and inactivated derivatives
XCV0357	COG0129	dihydroxy-acid dehydratase activity
XCV0360	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XCV0372	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XCV0373	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XCV0378	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XCV0379	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XCV0381	COG3485	protocatechuate 3,4-dioxygenase
XCV0382	COG3485	protocatechuate 3,4-dioxygenase
XCV0384	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XCV0385	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XCV0387	COG1414	Transcriptional regulator
XCV0391	COG0445	tRNA wobble uridine modification
XCV0394	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
XCV0399	COG1028	Short-chain dehydrogenase reductase Sdr
XCV0400	COG2267	carboxylic ester hydrolase activity
XCV0402	COG0156	8-amino-7-oxononanoate synthase activity
XCV0403	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XCV0404	COG1040	competence protein
XCV0405	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XCV0426	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XCV0438	COG2963	transposase activity
XCV0439	COG2801	Transposase and inactivated derivatives
XCV0445	COG3264	Mechanosensitive ion channel
XCV0445	COG1511	domain protein
XCV0446	COG1368	sulfuric ester hydrolase activity
XCV0448	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XCV0449	COG2354	Protein conserved in bacteria
XCV0450	COG3706	GGDEF domain
XCV0450	COG0745	RESPONSE REGULATOR receiver
XCV0451	COG0297	glycogen (starch) synthase activity
XCV0452	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XCV0453	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XCV0458	COG0702	epimerase
XCV0459	COG1028	Short-chain dehydrogenase reductase Sdr
XCV0466	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCV0467	COG1028	Short-chain dehydrogenase reductase Sdr
XCV0470	COG0513	Belongs to the DEAD box helicase family
XCV0473	COG0508	dehydrogenase complex catalyzes the overall conversion of
XCV0476	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
XCV0478	COG3483	tryptophan 2,3-dioxygenase activity
XCV0479	COG3104	oligopeptide transport
XCV0483	COG2852	Protein conserved in bacteria
XCV0484	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
XCV0487	COG1320	monovalent cation:proton antiporter activity
XCV0488	COG2212	antiporter activity
XCV0489	COG1863	multisubunit Na H antiporter MnhE subunit
XCV0490	COG0651	ATP synthesis coupled electron transport
XCV0491	COG1006	Multisubunit Na H antiporter MnhC subunit
XCV0492	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XCV0492	COG2111	Na H antiporter
XCV0496	COG3179	chitinase
XCV0500	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XCV0501	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XCV0502	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
XCV0503	COG0456	acetyltransferase
XCV0504	COG1597	lipid kinase activity
XCV0509	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XCV0516	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XCV0517	COG0134	indole-3-glycerol-phosphate synthase activity
XCV0519	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XCV0520	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XCV0522	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XCV0523	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XCV0524	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XCV0525	COG1051	belongs to the nudix hydrolase family
XCV0534	COG0316	Belongs to the HesB IscA family
XCV0538	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XCV0543	COG2814	Major facilitator Superfamily
XCV0544	COG1289	transmembrane transporter activity
XCV0545	COG0151	Belongs to the GarS family
XCV0547	COG0138	bifunctional purine biosynthesis protein purh
XCV0548	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XCV0549	COG2267	carboxylic ester hydrolase activity
XCV0550	COG2453	phosphatase
XCV0550	COG0671	phosphoesterase, PA-phosphatase related
XCV0555	COG4589	Belongs to the CDS family
XCV0556	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XCV0560	COG2264	protein methyltransferase activity
XCV0563	COG0439	Biotin carboxylase
XCV0565	COG0511	ligase activity, forming carbon-carbon bonds
XCV0566	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XCV0568	COG1324	tolerance protein
XCV0569	COG2356	endonuclease I
XCV0570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
XCV0571	COG0459	protein refolding
XCV0574	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XCV0577	COG3386	PFAM SMP-30 Gluconolaconase
XCV0579	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XCV0580	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XCV0587	COG0778	Nitroreductase
XCV0588	COG2353	YceI-like domain
XCV0595	COG3052	prosthetic group binding
XCV0599	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
XCV0600	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XCV0602	COG1802	Transcriptional regulator
XCV0603	COG0546	phosphoglycolate phosphatase activity
XCV0612	COG0464	growth
XCV0619	COG2963	transposase activity
XCV0622	COG3039	Transposase
XCV0624	COG4221	oxidoreductase activity
XCV0626	COG2963	transposase activity
XCV0627	COG4221	oxidoreductase activity
XCV0635	COG4221	oxidoreductase activity
XCV0637	COG0435	Glutathione S-transferase
XCV0645	COG3706	GGDEF domain
XCV0646	COG1959	2 iron, 2 sulfur cluster binding
XCV0652	COG0697	spore germination
XCV0656	COG1113	amino acid transport
XCV0658	COG0598	Magnesium transport protein CorA
XCV0660	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
XCV0669	COG0840	transmembrane signaling receptor activity
XCV0670	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCV0670	COG5297	Belongs to the glycosyl hydrolase family 6
XCV0671	COG0659	secondary active sulfate transmembrane transporter activity
XCV0672	COG3706	GGDEF domain
XCV0675	COG2943	transferase activity, transferring hexosyl groups
XCV0677	COG3275	phosphorelay sensor kinase activity
XCV0679	COG0181	hydroxymethylbilane synthase activity
XCV0685	COG1505	serine-type exopeptidase activity
XCV0688	COG2832	Protein of unknown function (DUF454)
XCV0689	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XCV0691	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XCV0692	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XCV0693	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XCV0699	COG3300	MHYT domain
XCV0699	COG5001	Diguanylate cyclase
XCV0700	COG0308	aminopeptidase N
XCV0705	COG2801	Transposase and inactivated derivatives
XCV0709	COG4993	Dehydrogenase
XCV0713	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
XCV0715	COG3284	Transcriptional regulator
XCV0717	COG1077	Cell shape determining protein MreB Mrl
XCV0718	COG1792	Involved in formation and maintenance of cell shape
XCV0721	COG0772	Belongs to the SEDS family
XCV0723	COG2951	lytic endotransglycosylase activity
XCV0724	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XCV0725	COG1686	Belongs to the peptidase S11 family
XCV0727	COG2921	Belongs to the UPF0250 family
XCV0728	COG0321	lipoyl(octanoyl) transferase activity
XCV0729	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XCV0732	COG0583	DNA-binding transcription factor activity
XCV0734	COG1051	belongs to the nudix hydrolase family
XCV0734	COG1056	cytidyltransferase-related domain
XCV0741	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XCV0742	COG0673	inositol 2-dehydrogenase activity
XCV0743	COG2823	Periplasmic or secreted lipoprotein
XCV0744	COG4251	negative regulation of phosphorylation
XCV0745	COG0784	Response regulator, receiver
XCV0746	COG4191	Histidine kinase
XCV0747	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XCV0758	COG1459	type II secretion system
XCV0762	COG4795	General secretion pathway protein
XCV0769	COG1609	Transcriptional regulator
XCV0770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XCV0771	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XCV0773	COG0617	tRNA 3'-terminal CCA addition
XCV0774	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XCV0775	COG1012	belongs to the aldehyde dehydrogenase family
XCV0776	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XCV0781	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XCV0783	COG2205	protein histidine kinase activity
XCV0784	COG0745	RESPONSE REGULATOR receiver
XCV0789	COG3791	Glutathione-dependent formaldehyde-activating
XCV0790	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
XCV0792	COG0488	(ABC) transporter
XCV0794	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XCV0796	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XCV0798	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XCV0798	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XCV0802	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XCV0803	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XCV0804	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XCV0808	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XCV0809	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XCV0811	COG2205	protein histidine kinase activity
XCV0812	COG0745	RESPONSE REGULATOR receiver
XCV0814	COG0277	FAD linked oxidase domain protein
XCV0815	COG1988	membrane-bound metal-dependent
XCV0816	COG0792	nuclease activity
XCV0822	COG2001	Belongs to the MraZ family
XCV0823	COG0275	rRNA processing
XCV0824	COG3116	cell division
XCV0826	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XCV0827	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XCV0828	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XCV0830	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XCV0831	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XCV0832	COG1181	Belongs to the D-alanine--D-alanine ligase family
XCV0833	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XCV0836	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XCV0838	COG0739	heme binding
XCV0839	COG0653	protein targeting
XCV0840	COG0494	nUDIX hydrolase
XCV0842	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XCV0844	COG3321	synthase
XCV0844	COG1028	Short-chain dehydrogenase reductase Sdr
XCV0844	COG0604	alcohol dehydrogenase
XCV0849	COG0366	Alpha amylase catalytic
XCV0850	COG0366	Alpha amylase catalytic
XCV0855	COG2226	methyltransferase
XCV0856	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XCV0858	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XCV0865	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XCV0867	COG4106	trans-aconitate 2-methyltransferase activity
XCV0868	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XCV0870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XCV0871	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XCV0873	COG0667	Aldo Keto reductase
XCV0875	COG4771	TonB-dependent receptor
XCV0880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XCV0881	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XCV0883	COG2175	clavaminate synthase activity
XCV0885	COG4181	ATPase activity
XCV0888	COG0642	Histidine kinase
XCV0890	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XCV0894	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XCV0895	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XCV0898	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XCV0899	COG2967	ApaG domain
XCV0900	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XCV0901	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XCV0902	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XCV0903	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XCV0904	COG0123	including yeast histone deacetylase and acetoin utilization protein
XCV0905	COG2096	Adenosyltransferase
XCV0907	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XCV0908	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XCV0914	COG3384	dioxygenase
XCV0915	COG0583	DNA-binding transcription factor activity
XCV0916	COG0318	PFAM AMP-dependent synthetase and ligase
XCV0918	COG1024	Enoyl-CoA hydratase
XCV0922	COG3386	PFAM SMP-30 Gluconolaconase
XCV0924	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XCV0928	COG0697	spore germination
XCV0930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XCV0933	COG0745	RESPONSE REGULATOR receiver
XCV0933	COG3706	GGDEF domain
XCV0935	COG2197	response regulator
XCV0937	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XCV0939	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XCV0940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XCV0941	COG0583	DNA-binding transcription factor activity
XCV0942	COG3634	alkyl hydroperoxide reductase activity
XCV0944	COG2890	protein-(glutamine-N5) methyltransferase activity
XCV0948	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XCV0948	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XCV0951	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XCV0955	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
XCV0958	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XCV0959	COG1404	Belongs to the peptidase S8 family
XCV0960	COG1404	Belongs to the peptidase S8 family
XCV0961	COG1404	Belongs to the peptidase S8 family
XCV0962	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XCV0968	COG1295	ribonuclease BN
XCV0969	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XCV0970	COG1254	Belongs to the acylphosphatase family
XCV0973	COG0521	Mo-molybdopterin cofactor biosynthetic process
XCV0975	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XCV0976	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XCV0978	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XCV0979	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XCV0980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XCV0981	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XCV0982	COG0193	aminoacyl-tRNA hydrolase activity
XCV0983	COG0012	GTP binding
XCV0984	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XCV0985	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XCV0986	COG0250	Participates in transcription elongation, termination and antitermination
XCV0987	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XCV0988	COG0081	regulation of translation
XCV0989	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XCV0990	COG0222	ribosome binding
XCV0991	COG0085	RNA polymerase activity
XCV0992	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XCV0993	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XCV0994	COG0049	tRNA binding
XCV0995	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XCV0996	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XCV0998	COG0051	transcription antitermination factor activity, RNA binding
XCV0999	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XCV1000	COG0088	Forms part of the polypeptide exit tunnel
XCV1001	COG0089	rRNA binding
XCV1002	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XCV1003	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XCV1004	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XCV1005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XCV1006	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XCV1007	COG0255	Belongs to the universal ribosomal protein uL29 family
XCV1008	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XCV1009	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
XCV1010	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XCV1011	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XCV1012	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XCV1013	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XCV1014	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XCV1015	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XCV1016	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XCV1017	COG1841	ribosomal large subunit assembly
XCV1018	COG0200	Binds to the 23S rRNA
XCV1019	COG0201	protein transport
XCV1020	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XCV1021	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
XCV1022	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XCV1023	COG0202	RNA polymerase activity
XCV1024	COG0203	ribosomal protein L17
XCV1026	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XCV1028	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XCV1030	COG0154	amidase activity
XCV1033	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XCV1034	COG0039	L-malate dehydrogenase activity
XCV1035	COG0625	glutathione transferase activity
XCV1039	COG1902	pentaerythritol trinitrate reductase activity
XCV1039	COG0446	pyridine nucleotide-disulphide oxidoreductase
XCV1041	COG0604	alcohol dehydrogenase
XCV1042	COG2885	chlorophyll binding
XCV1046	COG0156	8-amino-7-oxononanoate synthase activity
XCV1047	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XCV1048	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XCV1049	COG4208	sulfate ABC transporter
XCV1050	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XCV1052	COG1063	alcohol dehydrogenase
XCV1057	COG0406	alpha-ribazole phosphatase activity
XCV1058	COG0285	dihydrofolate synthase activity
XCV1062	COG2833	Protein of unknown function (DUF455)
XCV1064	COG3291	Pkd domain containing protein
XCV1066	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XCV1067	COG0671	phosphoesterase, PA-phosphatase related
XCV1068	COG0438	transferase activity, transferring glycosyl groups
XCV1070	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XCV1073	COG4783	chaperone-mediated protein folding
XCV1076	COG0473	3-isopropylmalate dehydrogenase activity
XCV1079	COG3852	Histidine kinase
XCV1080	COG0544	peptidyl-prolyl cis-trans isomerase activity
XCV1081	COG0740	serine-type endopeptidase activity
XCV1082	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XCV1085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XCV1087	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XCV1089	COG0328	RNA-DNA hybrid ribonuclease activity
XCV1090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XCV1091	COG0631	protein serine/threonine phosphatase activity
XCV1097	COG2963	transposase activity
XCV1102	COG0859	PFAM glycosyl transferase family 9
XCV1103	COG3642	lipopolysaccharide core region biosynthetic process
XCV1104	COG1234	tRNA 3'-trailer cleavage
XCV1105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XCV1107	COG0315	cyclic pyranopterin monophosphate synthase activity
XCV1108	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XCV1109	COG0314	molybdopterin synthase activity
XCV1113	COG2963	transposase activity
XCV1114	COG2801	Transposase and inactivated derivatives
XCV1115	COG2003	Belongs to the UPF0758 family
XCV1119	COG2801	Transposase and inactivated derivatives
XCV1121	COG0322	excinuclease ABC activity
XCV1128	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XCV1129	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XCV1130	COG0537	adenosine 5'-monophosphoramidase activity
XCV1134	COG0714	Associated with various cellular activities
XCV1137	COG0424	maF-like protein
XCV1138	COG2963	transposase activity
XCV1139	COG2801	Transposase and inactivated derivatives
XCV1140	COG0424	maF-like protein
XCV1142	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XCV1143	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XCV1147	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XCV1149	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XCV1150	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XCV1155	COG3829	transcription factor binding
XCV1160	COG2828	Protein conserved in bacteria
XCV1164	COG2373	Large extracellular alpha-helical protein
XCV1168	COG4953	penicillin-binding protein 1C
XCV1170	COG0678	peroxiredoxin activity
XCV1175	COG0330	HflC and HflK could
XCV1176	COG0330	HflC and HflK could
XCV1178	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XCV1179	COG0308	aminopeptidase N
XCV1181	COG1028	Short-chain dehydrogenase reductase Sdr
XCV1182	COG1309	transcriptional regulator
XCV1191	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
XCV1193	COG0732	type I restriction modification DNA specificity domain
XCV1194	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XCV1200	COG0328	RNA-DNA hybrid ribonuclease activity
XCV1200	COG0406	alpha-ribazole phosphatase activity
XCV1201	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XCV1203	COG3387	PFAM Glycoside hydrolase 15-related
XCV1204	COG1028	Short-chain dehydrogenase reductase Sdr
XCV1205	COG3537	Alpha-1,2-mannosidase
XCV1206	COG1028	Short-chain dehydrogenase reductase Sdr
XCV1208	COG0492	ferredoxin-NADP+ reductase activity
XCV1214	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XCV1215	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XCV1216	COG2080	2 iron, 2 sulfur cluster binding
XCV1223	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XCV1226	COG0587	DNA-directed DNA polymerase activity
XCV1230	COG1297	OPT oligopeptide transporter protein
XCV1232	COG0823	Involved in the tonB-independent uptake of proteins
XCV1232	COG1506	peptidase
XCV1235	COG1917	Cupin 2, conserved barrel domain protein
XCV1235	COG2207	Transcriptional regulator
XCV1240	COG0753	catalase activity
XCV1241	COG0656	L-ascorbic acid biosynthetic process
XCV1242	COG2272	Belongs to the type-B carboxylesterase lipase family
XCV1243	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XCV1243	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XCV1247	COG2814	Major facilitator Superfamily
XCV1250	COG2194	sulfuric ester hydrolase activity
XCV1253	COG0745	RESPONSE REGULATOR receiver
XCV1254	COG0642	Histidine kinase
XCV1256	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XCV1257	COG2894	cell division
XCV1258	COG0850	regulation of cytokinetic process
XCV1260	COG4585	Histidine kinase
XCV1261	COG2197	response regulator
XCV1264	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XCV1269	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
XCV1273	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XCV1276	COG1595	DNA-templated transcription, initiation
XCV1278	COG1946	Acyl-CoA thioesterase
XCV1280	COG1024	Enoyl-CoA hydratase
XCV1282	COG0824	Thioesterase
XCV1283	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XCV1284	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XCV1285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XCV1286	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XCV1287	COG0268	Binds directly to 16S ribosomal RNA
XCV1288	COG0728	peptidoglycan biosynthetic process
XCV1289	COG0196	riboflavin kinase activity
XCV1290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XCV1291	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XCV1292	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XCV1294	COG3039	Transposase
XCV1301	COG2963	transposase activity
XCV1308	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XCV1309	COG1845	cytochrome c oxidase, subunit III
XCV1310	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XCV1313	COG3152	Membrane
XCV1315	COG2207	Transcriptional regulator
XCV1316	COG0326	Molecular chaperone. Has ATPase activity
XCV1319	COG1366	Belongs to the anti-sigma-factor antagonist family
XCV1320	COG1366	Belongs to the anti-sigma-factor antagonist family
XCV1321	COG2172	sigma factor antagonist activity
XCV1326	COG4771	TonB-dependent receptor
XCV1328	COG5507	3-demethylubiquinone-9 3-methyltransferase
XCV1329	COG2205	protein histidine kinase activity
XCV1331	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XCV1332	COG4999	Histidine kinase
XCV1332	COG3850	Histidine kinase
XCV1332	COG3437	response regulator, receiver
XCV1332	COG2205	protein histidine kinase activity
XCV1333	COG0784	Response regulator, receiver
XCV1333	COG4191	Histidine kinase
XCV1337	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XCV1338	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XCV1341	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XCV1342	COG0228	four-way junction DNA binding
XCV1343	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XCV1344	COG0336	Belongs to the RNA methyltransferase TrmD family
XCV1345	COG0335	large ribosomal subunit rRNA binding
XCV1346	COG0534	Mate efflux family protein
XCV1350	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XCV1352	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XCV1355	COG2801	Transposase and inactivated derivatives
XCV1356	COG2963	transposase activity
XCV1359	COG3250	beta-galactosidase activity
XCV1360	COG3867	Arabinogalactan endo-beta-1,4-galactanase
XCV1364	COG1960	acyl-CoA dehydrogenase activity
XCV1365	COG1024	Enoyl-CoA hydratase
XCV1369	COG1250	3-hydroxyacyl-CoA dehydrogenase
XCV1369	COG1024	Enoyl-CoA hydratase
XCV1372	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XCV1373	COG0481	GTPase activity
XCV1376	COG0571	ribonuclease III activity
XCV1377	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XCV1379	COG1381	Involved in DNA repair and RecF pathway recombination
XCV1381	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XCV1383	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XCV1384	COG1233	COG1233 Phytoene dehydrogenase and related
XCV1385	COG3046	protein related to deoxyribodipyrimidine photolyase
XCV1386	COG1472	Belongs to the glycosyl hydrolase 3 family
XCV1388	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XCV1389	COG1278	Cold shock
XCV1390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XCV1393	COG1201	RNA secondary structure unwinding
XCV1394	COG1793	dna ligase
XCV1395	COG1793	dna ligase
XCV1395	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XCV1398	COG0745	RESPONSE REGULATOR receiver
XCV1398	COG3706	GGDEF domain
XCV1401	COG0183	Belongs to the thiolase family
XCV1405	COG1451	nucleotide metabolic process
XCV1406	COG5487	UPF0391 membrane protein
XCV1408	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XCV1411	COG1077	Cell shape determining protein MreB Mrl
XCV1412	COG1047	Peptidyl-prolyl cis-trans
XCV1413	COG1047	Peptidyl-prolyl cis-trans
XCV1415	COG2824	Alkylphosphonate utilization operon protein PhnA
XCV1417	COG1902	pentaerythritol trinitrate reductase activity
XCV1418	COG2814	Major facilitator Superfamily
XCV1425	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XCV1425	COG0392	lysyltransferase activity
XCV1427	COG0251	oxidation-reduction process
XCV1428	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XCV1431	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XCV1436	COG1595	DNA-templated transcription, initiation
XCV1439	COG2878	Part of a membrane complex involved in electron transport
XCV1441	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XCV1441	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XCV1445	COG0346	lactoylglutathione lyase activity
XCV1448	COG0833	amino acid
XCV1449	COG2040	homocysteine
XCV1451	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XCV1455	COG1695	Transcriptional regulator
XCV1462	COG0825	malonyl-CoA metabolic process
XCV1463	COG0587	DNA-directed DNA polymerase activity
XCV1464	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XCV1465	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XCV1466	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XCV1467	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XCV1468	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XCV1471	COG0750	zinc metalloprotease
XCV1472	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XCV1473	COG0575	Belongs to the CDS family
XCV1474	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XCV1475	COG0233	cytoplasmic translational termination
XCV1476	COG0528	UMP kinase activity
XCV1477	COG3706	GGDEF domain
XCV1477	COG0745	RESPONSE REGULATOR receiver
XCV1478	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XCV1479	COG0052	Belongs to the universal ribosomal protein uS2 family
XCV1485	COG0024	Methionine aminopeptidase
XCV1486	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XCV1488	COG1393	Belongs to the ArsC family
XCV1489	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XCV1490	COG0367	asparagine synthase
XCV1496	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XCV1501	COG1566	PFAM secretion protein HlyD family protein
XCV1502	COG2814	Major facilitator Superfamily
XCV1513	COG0339	signal peptide processing
XCV1514	COG0386	Belongs to the glutathione peroxidase family
XCV1525	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XCV1526	COG0084	hydrolase, TatD family'
XCV1529	COG1960	acyl-CoA dehydrogenase activity
XCV1533	COG0367	asparagine synthase
XCV1535	COG0305	Participates in initiation and elongation during chromosome replication
XCV1536	COG0415	Belongs to the DNA photolyase family
XCV1538	COG0583	DNA-binding transcription factor activity
XCV1544	COG3706	GGDEF domain
XCV1546	COG3706	GGDEF domain
XCV1550	COG2963	transposase activity
XCV1556	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XCV1559	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XCV1561	COG0497	DNA recombination
XCV1562	COG1420	regulation of RNA biosynthetic process
XCV1563	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XCV1564	COG0443	Heat shock 70 kDa protein
XCV1565	COG0484	heat shock protein binding
XCV1566	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XCV1572	COG0583	DNA-binding transcription factor activity
XCV1573	COG1132	(ABC) transporter
XCV1580	COG2850	peptidyl-arginine hydroxylation
XCV1584	COG1253	flavin adenine dinucleotide binding
XCV1590	COG1131	(ABC) transporter
XCV1591	COG1725	Transcriptional regulator
XCV1592	COG0386	Belongs to the glutathione peroxidase family
XCV1595	COG2900	Belongs to the SlyX family
XCV1600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XCV1602	COG0646	methionine synthase
XCV1602	COG1410	methionine synthase
XCV1603	COG0646	methionine synthase
XCV1603	COG1410	methionine synthase
XCV1605	COG1960	acyl-CoA dehydrogenase activity
XCV1607	COG0557	exoribonuclease II activity
XCV1609	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XCV1610	COG3706	GGDEF domain
XCV1611	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XCV1613	COG0704	Plays a role in the regulation of phosphate uptake
XCV1614	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XCV1615	COG0581	inorganic phosphate transmembrane transporter activity
XCV1616	COG0573	inorganic phosphate transmembrane transporter activity
XCV1617	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XCV1622	COG0659	secondary active sulfate transmembrane transporter activity
XCV1623	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XCV1625	COG1024	Enoyl-CoA hydratase
XCV1627	COG0494	nUDIX hydrolase
XCV1635	COG0116	Belongs to the methyltransferase superfamily
XCV1635	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XCV1636	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XCV1640	COG2925	Exonuclease
XCV1641	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XCV1642	COG3844	kynureninase activity
XCV1645	COG0662	Cupin 2, conserved barrel domain protein
XCV1646	COG0288	reversible hydration of carbon dioxide
XCV1656	COG2808	Putative FMN-binding domain
XCV1659	COG0017	Asparaginyl-tRNA synthetase
XCV1660	COG0316	Belongs to the HesB IscA family
XCV1661	COG0360	Binds together with S18 to 16S ribosomal RNA
XCV1662	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XCV1663	COG0359	binds to the 23S rRNA
XCV1665	COG3115	cell septum assembly
XCV1667	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XCV1668	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XCV1669	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XCV1671	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XCV1673	COG4993	Dehydrogenase
XCV1676	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XCV1678	COG2986	histidine ammonia-lyase
XCV1679	COG1228	amidohydrolase
XCV1687	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
XCV1688	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XCV1689	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XCV1690	COG0077	Prephenate dehydratase
XCV1690	COG1605	Chorismate mutase
XCV1691	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XCV1694	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XCV1695	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XCV1696	COG0583	DNA-binding transcription factor activity
XCV1699	COG2801	Transposase and inactivated derivatives
XCV1702	COG0840	transmembrane signaling receptor activity
XCV1706	COG0745	RESPONSE REGULATOR receiver
XCV1707	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XCV1708	COG0784	Response regulator, receiver
XCV1708	COG4191	Histidine kinase
XCV1711	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XCV1713	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XCV1715	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XCV1718	COG1595	DNA-templated transcription, initiation
XCV1725	COG2244	polysaccharide biosynthetic process
XCV1731	COG2264	protein methyltransferase activity
XCV1733	COG0438	transferase activity, transferring glycosyl groups
XCV1736	COG1136	(ABC) transporter
XCV1737	COG1132	(ABC) transporter
XCV1740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XCV1743	COG1253	flavin adenine dinucleotide binding
XCV1745	COG0306	phosphate transporter
XCV1749	COG0504	CTP synthase activity
XCV1750	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XCV1752	COG0148	phosphopyruvate hydratase activity
XCV1753	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XCV1754	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XCV1755	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XCV1756	COG0585	pseudouridine synthase activity
XCV1757	COG2840	Smr protein MutS2
XCV1758	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XCV1759	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XCV1760	COG1238	metal cluster binding
XCV1763	COG1534	Rna-binding protein
XCV1764	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XCV1765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XCV1766	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XCV1767	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XCV1768	COG1923	regulation of RNA biosynthetic process
XCV1769	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XCV1770	COG1546	Belongs to the CinA family
XCV1772	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XCV1773	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XCV1774	COG2137	regulation of response to DNA damage stimulus
XCV1775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XCV1776	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XCV1780	COG1741	Belongs to the pirin family
XCV1781	COG0583	DNA-binding transcription factor activity
XCV1784	COG0351	phosphomethylpyrimidine kinase
XCV1787	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XCV1788	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XCV1791	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XCV1793	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XCV1794	COG3734	2-keto-3-deoxy-galactonokinase
XCV1796	COG4948	Mandelate Racemase Muconate Lactonizing
XCV1797	COG0800	Aldolase
XCV1805	COG1501	Belongs to the glycosyl hydrolase 31 family
XCV1807	COG1070	Carbohydrate kinase
XCV1808	COG2115	Belongs to the xylose isomerase family
XCV1809	COG0477	Major facilitator Superfamily
XCV1812	COG0860	N-Acetylmuramoyl-L-alanine amidase
XCV1813	COG1469	GTP cyclohydrolase I activity
XCV1816	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XCV1817	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XCV1818	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XCV1819	COG0166	Belongs to the GPI family
XCV1823	COG1472	Belongs to the glycosyl hydrolase 3 family
XCV1825	COG3706	GGDEF domain
XCV1825	COG4251	negative regulation of phosphorylation
XCV1825	COG2203	Gaf domain
XCV1825	COG5001	Diguanylate cyclase
XCV1826	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCV1827	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XCV1829	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XCV1830	COG0671	phosphoesterase, PA-phosphatase related
XCV1832	COG1794	racemase activity, acting on amino acids and derivatives
XCV1833	COG0697	spore germination
XCV1834	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XCV1835	COG0167	dihydroorotate dehydrogenase activity
XCV1838	COG1012	belongs to the aldehyde dehydrogenase family
XCV1841	COG2963	transposase activity
XCV1844	COG2801	Transposase and inactivated derivatives
XCV1846	COG2801	Transposase and inactivated derivatives
XCV1847	COG2963	transposase activity
XCV1849	COG2801	Transposase and inactivated derivatives
XCV1850	COG2801	Transposase and inactivated derivatives
XCV1851	COG2963	transposase activity
XCV1860	COG3210	domain, Protein
XCV1862	COG2963	transposase activity
XCV1865	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
XCV1866	COG0527	aspartate kinase activity
XCV1866	COG0460	homoserine dehydrogenase
XCV1869	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
XCV1871	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XCV1872	COG0124	histidyl-tRNA synthetase
XCV1874	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XCV1875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XCV1876	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XCV1877	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XCV1877	COG0131	Imidazoleglycerol-phosphate dehydratase
XCV1878	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XCV1879	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XCV1880	COG0107	imidazoleglycerol-phosphate synthase activity
XCV1881	COG0140	phosphoribosyl-ATP diphosphatase activity
XCV1881	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XCV1884	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XCV1885	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XCV1886	COG0235	Class ii aldolase
XCV1887	COG0531	amino acid
XCV1888	COG0531	amino acid
XCV1890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XCV1891	COG0277	FAD linked oxidase domain protein
XCV1895	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XCV1904	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XCV1905	COG2258	MOSC domain
XCV1906	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XCV1907	COG0505	Belongs to the CarA family
XCV1909	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XCV1910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XCV1912	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XCV1914	COG3279	Response regulator of the LytR AlgR family
XCV1915	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XCV1916	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XCV1919	COG2205	protein histidine kinase activity
XCV1919	COG2198	Histidine kinase
XCV1919	COG0784	Response regulator, receiver
XCV1920	COG1024	Enoyl-CoA hydratase
XCV1921	COG0318	PFAM AMP-dependent synthetase and ligase
XCV1928	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XCV1930	COG2201	protein-glutamate methylesterase activity
XCV1931	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
XCV1933	COG0840	transmembrane signaling receptor activity
XCV1935	COG0835	chemotaxis
XCV1938	COG0840	transmembrane signaling receptor activity
XCV1939	COG0840	transmembrane signaling receptor activity
XCV1940	COG0840	transmembrane signaling receptor activity
XCV1941	COG0840	transmembrane signaling receptor activity
XCV1942	COG0840	transmembrane signaling receptor activity
XCV1944	COG0840	transmembrane signaling receptor activity
XCV1945	COG0840	transmembrane signaling receptor activity
XCV1947	COG0840	transmembrane signaling receptor activity
XCV1948	COG0840	transmembrane signaling receptor activity
XCV1951	COG0840	transmembrane signaling receptor activity
XCV1952	COG0840	transmembrane signaling receptor activity
XCV1954	COG0840	transmembrane signaling receptor activity
XCV1955	COG0840	transmembrane signaling receptor activity
XCV1957	COG0745	RESPONSE REGULATOR receiver
XCV1959	COG0835	chemotaxis
XCV1960	COG1192	Involved in chromosome partitioning
XCV1961	COG1360	Flagellar Motor Protein
XCV1962	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XCV1968	COG2963	transposase activity
XCV1974	COG2198	Histidine kinase
XCV1974	COG0643	Histidine kinase
XCV1978	COG0455	bacterial-type flagellum organization
XCV1983	COG5001	Diguanylate cyclase
XCV1983	COG3300	MHYT domain
XCV1985	COG3300	MHYT domain
XCV1985	COG5001	Diguanylate cyclase
XCV1986	COG1684	flagellar biosynthetic protein fliR
XCV1987	COG1987	bacterial-type flagellum assembly
XCV1989	COG3190	flagellar
XCV1999	COG1677	Flagellar hook-basal body complex protein FliE
XCV2002	COG0275	rRNA processing
XCV2003	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XCV2010	COG1028	Short-chain dehydrogenase reductase Sdr
XCV2011	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XCV2014	COG2204	response regulator
XCV2015	COG2201	protein-glutamate methylesterase activity
XCV2021	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
XCV2022	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XCV2023	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XCV2025	COG1705	Flagellar rod assembly protein muramidase FlgJ
XCV2025	COG3951	Flagellar rod assembly protein muramidase FlgJ
XCV2026	COG1706	bacterial-type flagellum-dependent cell motility
XCV2027	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XCV2028	COG4786	Flagellar basal body rod
XCV2029	COG4787	bacterial-type flagellum-dependent cell motility
XCV2030	COG1749	Flagellar hook protein flgE
XCV2031	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XCV2032	COG1558	bacterial-type flagellum-dependent cell motility
XCV2034	COG0835	chemotaxis
XCV2034	COG0784	Response regulator, receiver
XCV2038	COG5002	protein histidine kinase activity
XCV2045	COG2915	High frequency lysogenization protein hflD homolog
XCV2046	COG0482	sulfurtransferase activity
XCV2048	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XCV2049	COG0542	response to heat
XCV2051	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
XCV2052	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XCV2055	COG0492	ferredoxin-NADP+ reductase activity
XCV2056	COG1674	ftsk spoiiie
XCV2058	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XCV2060	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XCV2061	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XCV2063	COG0183	Belongs to the thiolase family
XCV2064	COG1024	Enoyl-CoA hydratase
XCV2064	COG1250	3-hydroxyacyl-CoA dehydrogenase
XCV2066	COG0105	UTP biosynthetic process
XCV2067	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XCV2069	COG1426	Protein conserved in bacteria
XCV2071	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XCV2072	COG1160	GTP binding
XCV2073	COG0303	'Molybdopterin
XCV2074	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XCV2081	COG0708	Exodeoxyribonuclease III
XCV2083	COG0303	'Molybdopterin
XCV2084	COG0746	molybdenum cofactor guanylyltransferase activity
XCV2089	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XCV2089	COG1648	precorrin-2 dehydrogenase activity
XCV2091	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XCV2092	COG2223	nitrite transmembrane transporter activity
XCV2093	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XCV2095	COG0243	molybdopterin cofactor binding
XCV2099	COG3685	Protein conserved in bacteria
XCV2102	COG5001	Diguanylate cyclase
XCV2104	COG4566	intracellular signal transduction
XCV2108	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCV2112	COG3279	Response regulator of the LytR AlgR family
XCV2133	COG3501	Rhs element vgr protein
XCV2140	COG0631	protein serine/threonine phosphatase activity
XCV2141	COG0515	serine threonine protein kinase
XCV2144	COG0583	DNA-binding transcription factor activity
XCV2146	COG1858	cytochrome C peroxidase
XCV2152	COG4585	Histidine kinase
XCV2153	COG2197	response regulator
XCV2157	COG2801	Transposase and inactivated derivatives
XCV2165	COG1002	Type II restriction enzyme, methylase subunits
XCV2166	COG1061	Type III restriction enzyme res subunit
XCV2167	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XCV2168	COG1196	nuclear chromosome segregation
XCV2171	COG2818	Glycosylase
XCV2172	COG1028	Short-chain dehydrogenase reductase Sdr
XCV2174	COG0583	DNA-binding transcription factor activity
XCV2175	COG0667	Aldo Keto reductase
XCV2176	COG3002	Belongs to the UPF0753 family
XCV2177	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XCV2178	COG0583	DNA-binding transcription factor activity
XCV2180	COG0633	Ferredoxin
XCV2184	COG0583	DNA-binding transcription factor activity
XCV2187	COG2197	response regulator
XCV2188	COG4585	Histidine kinase
XCV2190	COG1335	isochorismatase
XCV2193	COG2814	Major facilitator Superfamily
XCV2197	COG1914	H( )-stimulated, divalent metal cation uptake system
XCV2198	COG1321	iron dependent repressor
XCV2199	COG0590	tRNA wobble adenosine to inosine editing
XCV2200	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XCV2201	COG0668	transmembrane transport
XCV2203	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XCV2206	COG1028	Short-chain dehydrogenase reductase Sdr
XCV2207	COG1183	phosphatidylcholine synthase activity
XCV2209	COG3243	poly(R)-hydroxyalkanoic acid synthase
XCV2212	COG0723	plastoquinol--plastocyanin reductase activity
XCV2212	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCV2214	COG2183	response to ionizing radiation
XCV2215	COG2205	protein histidine kinase activity
XCV2215	COG0784	Response regulator, receiver
XCV2217	COG0582	viral genome integration into host DNA
XCV2233	COG0800	Aldolase
XCV2234	COG0129	dihydroxy-acid dehydratase activity
XCV2235	COG0363	glucosamine-6-phosphate deaminase activity
XCV2236	COG0837	glucose binding
XCV2237	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XCV2239	COG0354	folic acid binding
XCV2242	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XCV2245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XCV2246	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XCV2248	COG4591	ABC-type transport system involved in lipoprotein release permease component
XCV2249	COG1136	(ABC) transporter
XCV2252	COG0811	peptide transport
XCV2254	COG1132	(ABC) transporter
XCV2255	COG1663	tetraacyldisaccharide 4'-kinase activity
XCV2256	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XCV2257	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XCV2259	COG0322	excinuclease ABC activity
XCV2260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XCV2261	COG0582	viral genome integration into host DNA
XCV2262	COG2801	Transposase and inactivated derivatives
XCV2273	COG4644	lycopene metabolic process
XCV2286	COG0270	DNA (cytosine-5-)-methyltransferase activity
XCV2288	COG0629	single-stranded DNA binding
XCV2296	COG2801	Transposase and inactivated derivatives
XCV2298	COG0582	viral genome integration into host DNA
XCV2300	COG1396	sequence-specific DNA binding
XCV2301	COG0583	DNA-binding transcription factor activity
XCV2307	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XCV2308	COG4232	protein-disulfide reductase activity
XCV2309	COG0745	RESPONSE REGULATOR receiver
XCV2311	COG0492	ferredoxin-NADP+ reductase activity
XCV2315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XCV2316	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
XCV2318	COG1275	C4-dicarboxylate transporter malic acid transport protein
XCV2320	COG3316	Transposase and inactivated derivatives
XCV2324	COG1573	uracil-dna glycosylase
XCV2327	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XCV2329	COG3316	Transposase and inactivated derivatives
XCV2332	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
XCV2334	COG2814	Major facilitator Superfamily
XCV2335	COG0789	Transcriptional regulator
XCV2337	COG0640	Transcriptional regulator
XCV2338	COG1230	cation diffusion facilitator family transporter
XCV2340	COG3316	Transposase and inactivated derivatives
XCV2350	COG2814	Major facilitator Superfamily
XCV2353	COG3316	Transposase and inactivated derivatives
XCV2354	COG0583	DNA-binding transcription factor activity
XCV2365	COG2003	Belongs to the UPF0758 family
XCV2405	COG0270	DNA (cytosine-5-)-methyltransferase activity
XCV2406	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XCV2407	COG0629	single-stranded DNA binding
XCV2414	COG1192	Involved in chromosome partitioning
XCV2417	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XCV2423	COG1530	ribonuclease E activity
XCV2425	COG3064	Membrane
XCV2426	COG0428	transporter
XCV2428	COG2154	pterin-4-alpha-carbinolamine dehydratase
XCV2429	COG0316	Belongs to the HesB IscA family
XCV2429	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XCV2432	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCV2433	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCV2435	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XCV2439	COG4644	lycopene metabolic process
XCV2440	COG2951	lytic endotransglycosylase activity
XCV2441	COG0730	response to heat
XCV2446	COG0640	Transcriptional regulator
XCV2476	COG1484	DNA-dependent DNA replication
XCV2478	COG2801	Transposase and inactivated derivatives
XCV2484	COG0582	viral genome integration into host DNA
XCV2485	COG0519	Catalyzes the synthesis of GMP from XMP
XCV2485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XCV2487	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XCV2489	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XCV2489	COG0475	glutathione-regulated potassium exporter activity
XCV2490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XCV2492	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XCV2493	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XCV2495	COG0776	regulation of translation
XCV2496	COG0539	negative regulation of cytoplasmic translation
XCV2497	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XCV2498	COG0257	Belongs to the bacterial ribosomal protein bL36 family
XCV2500	COG2957	Belongs to the agmatine deiminase family
XCV2501	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XCV2506	COG0395	ABC-type sugar transport system, permease component
XCV2507	COG1175	transmembrane transport
XCV2514	COG2350	Protein conserved in bacteria
XCV2515	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XCV2516	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XCV2517	COG1187	pseudouridine synthase activity
XCV2521	COG0436	Aminotransferase
XCV2522	COG4133	protoheme IX ABC transporter activity
XCV2526	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XCV2527	COG1138	Cytochrome C-type biogenesis protein
XCV2531	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XCV2532	COG1278	Cold shock
XCV2533	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XCV2534	COG4988	ABC transporter
XCV2536	COG1294	oxidase, subunit
XCV2541	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XCV2542	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XCV2544	COG0165	Argininosuccinate lyase
XCV2545	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XCV2547	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XCV2550	COG0137	argininosuccinate synthase activity
XCV2551	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XCV2553	COG0215	cysteine-tRNA ligase activity
XCV2554	COG2166	iron-sulfur cluster assembly
XCV2556	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XCV2558	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XCV2559	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XCV2563	COG4303	Ethanolamine ammonia lyase large subunit
XCV2564	COG4302	ethanolamine ammonia-lyase activity
XCV2574	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XCV2575	COG0402	S-adenosylhomocysteine deaminase activity
XCV2577	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XCV2578	COG1509	lysine 2,3-aminomutase activity
XCV2579	COG3300	MHYT domain
XCV2579	COG5001	Diguanylate cyclase
XCV2582	COG0483	inositol monophosphate 1-phosphatase activity
XCV2587	COG0513	Belongs to the DEAD box helicase family
XCV2588	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XCV2589	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XCV2591	COG0625	glutathione transferase activity
XCV2593	COG4681	YaeQ
XCV2594	COG2081	HI0933 family
XCV2596	COG0501	Belongs to the peptidase M48B family
XCV2597	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XCV2598	COG1028	Short-chain dehydrogenase reductase Sdr
XCV2602	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XCV2603	COG0860	N-Acetylmuramoyl-L-alanine amidase
XCV2604	COG0802	atpase or kinase
XCV2605	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XCV2605	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XCV2606	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XCV2607	COG1570	exodeoxyribonuclease VII activity
XCV2610	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XCV2615	COG0582	viral genome integration into host DNA
XCV2617	COG2963	transposase activity
XCV2624	COG0835	chemotaxis
XCV2625	COG0840	transmembrane signaling receptor activity
XCV2626	COG2094	Belongs to the DNA glycosylase MPG family
XCV2627	COG1201	RNA secondary structure unwinding
XCV2630	COG2969	positive regulation of protein catabolic process
XCV2631	COG0625	glutathione transferase activity
XCV2632	COG2857	Cytochrome c1
XCV2633	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XCV2634	COG0723	plastoquinol--plastocyanin reductase activity
XCV2635	COG0741	lytic transglycosylase activity
XCV2638	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XCV2640	COG1702	phosphate starvation-inducible protein PhoH
XCV2642	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XCV2644	COG4535	Mg2 and Co2 transporter CorC
XCV2647	COG1012	belongs to the aldehyde dehydrogenase family
XCV2648	COG1177	transmembrane transport
XCV2649	COG1176	ABC-type spermidine putrescine transport system, permease component I
XCV2650	COG3842	ATPase activity
XCV2654	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XCV2657	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XCV2658	COG0174	glutamine synthetase
XCV2659	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCV2660	COG0745	RESPONSE REGULATOR receiver
XCV2660	COG3706	GGDEF domain
XCV2661	COG2703	oxygen carrier activity
XCV2662	COG0477	Major facilitator Superfamily
XCV2664	COG0243	molybdopterin cofactor binding
XCV2665	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XCV2670	COG2733	membrane
XCV2671	COG2205	protein histidine kinase activity
XCV2671	COG5002	protein histidine kinase activity
XCV2671	COG0784	Response regulator, receiver
XCV2673	COG0477	Major facilitator Superfamily
XCV2674	COG2902	Dehydrogenase
XCV2676	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCV2677	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCV2678	COG1609	Transcriptional regulator
XCV2679	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XCV2679	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XCV2680	COG1105	Belongs to the carbohydrate kinase PfkB family
XCV2681	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XCV2681	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XCV2689	COG2801	Transposase and inactivated derivatives
XCV2692	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XCV2694	COG1862	Preprotein translocase
XCV2695	COG0343	queuine tRNA-ribosyltransferase activity
XCV2696	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XCV2703	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XCV2704	COG3291	Pkd domain containing protein
XCV2706	COG0405	Gamma-glutamyltransferase
XCV2707	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XCV2709	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XCV2710	COG0742	ribosomal rna small subunit methyltransferase
XCV2711	COG0326	Molecular chaperone. Has ATPase activity
XCV2714	COG3039	Transposase
XCV2722	COG2963	transposase activity
XCV2739	COG0531	amino acid
XCV2742	COG0006	proline dipeptidase activity
XCV2744	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XCV2747	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCV2748	COG3938	Belongs to the proline racemase family
XCV2750	COG0552	protein localization to endoplasmic reticulum
XCV2752	COG1194	a g-specific adenine glycosylase
XCV2753	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XCV2754	COG4191	Histidine kinase
XCV2754	COG0784	Response regulator, receiver
XCV2757	COG0322	excinuclease ABC activity
XCV2758	COG0322	excinuclease ABC activity
XCV2760	COG3040	lipid binding
XCV2762	COG1960	acyl-CoA dehydrogenase activity
XCV2764	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XCV2768	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XCV2769	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XCV2770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XCV2773	COG2963	transposase activity
XCV2780	COG0438	transferase activity, transferring glycosyl groups
XCV2781	COG0438	transferase activity, transferring glycosyl groups
XCV2789	COG0776	regulation of translation
XCV2790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XCV2790	COG0072	phenylalanine-tRNA ligase activity
XCV2791	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XCV2792	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
XCV2793	COG0291	Belongs to the bacterial ribosomal protein bL35 family
XCV2794	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XCV2795	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XCV2800	COG1082	Xylose isomerase domain protein TIM barrel
XCV2803	COG0366	Alpha amylase catalytic
XCV2805	COG2963	transposase activity
XCV2810	COG3505	Type IV secretory pathway VirD4
XCV2812	COG0556	nucleotide-excision repair
XCV2817	COG2963	transposase activity
XCV2822	COG1611	Belongs to the LOG family
XCV2824	COG2095	MarC family integral membrane protein
XCV2826	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XCV2827	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XCV2833	COG1185	polyribonucleotide nucleotidyltransferase activity
XCV2834	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XCV2835	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XCV2836	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XCV2837	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XCV2838	COG0195	Participates in both transcription termination and antitermination
XCV2839	COG0779	Required for maturation of 30S ribosomal subunits
XCV2840	COG1007	ATP synthesis coupled electron transport
XCV2843	COG0713	ATP synthesis coupled electron transport
XCV2845	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XCV2846	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XCV2847	COG1034	ATP synthesis coupled electron transport
XCV2848	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XCV2849	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XCV2850	COG0649	NAD binding
XCV2851	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XCV2852	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XCV2853	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XCV2855	COG0149	triose-phosphate isomerase activity
XCV2856	COG4221	oxidoreductase activity
XCV2863	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XCV2864	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XCV2865	COG0159	tryptophan synthase activity
XCV2866	COG2801	Transposase and inactivated derivatives
XCV2869	COG0133	tryptophan synthase activity
XCV2871	COG0135	phosphoribosylanthranilate isomerase activity
XCV2872	COG0101	tRNA pseudouridine synthase activity
XCV2875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XCV2876	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XCV2877	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XCV2878	COG2890	protein-(glutamine-N5) methyltransferase activity
XCV2880	COG0688	phosphatidylethanolamine metabolic process
XCV2882	COG0433	COG0433 Predicted ATPase
XCV2883	COG0494	nUDIX hydrolase
XCV2886	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XCV2887	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XCV2892	COG0717	Belongs to the dCTP deaminase family
XCV2893	COG0489	protein tyrosine kinase activity
XCV2898	COG3590	peptidase
XCV2899	COG3590	peptidase
XCV2903	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XCV2904	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCV2905	COG2311	Membrane
XCV2906	COG1047	Peptidyl-prolyl cis-trans
XCV2907	COG0791	NLP P60 protein
XCV2908	COG0791	NLP P60 protein
XCV2912	COG1301	dicarboxylic acid transport
XCV2913	COG1785	Belongs to the alkaline phosphatase family
XCV2914	COG0037	tRNA processing
XCV2915	COG1722	exodeoxyribonuclease VII activity
XCV2916	COG0142	geranyltranstransferase activity
XCV2918	COG4104	PAAR repeat-containing protein
XCV2920	COG0312	modulator of DNA gyrase
XCV2921	COG3028	Belongs to the UPF0307 family
XCV2923	COG0312	modulator of DNA gyrase
XCV2926	COG3164	Protein of unknown function
XCV2927	COG1530	ribonuclease E activity
XCV2928	COG0424	maF-like protein
XCV2929	COG2968	Membrane
XCV2931	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XCV2934	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XCV2938	COG0495	leucyl-tRNA aminoacylation
XCV2940	COG3118	belongs to the thioredoxin family
XCV2945	COG2155	Conserved Protein
XCV2946	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XCV2956	COG1132	(ABC) transporter
XCV2963	COG1538	Outer membrane efflux protein
XCV2964	COG0745	RESPONSE REGULATOR receiver
XCV2965	COG5002	protein histidine kinase activity
XCV2965	COG5000	phosphorelay sensor kinase activity
XCV2966	COG0475	glutathione-regulated potassium exporter activity
XCV2967	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
XCV2968	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XCV2971	COG3706	GGDEF domain
XCV2972	COG1187	pseudouridine synthase activity
XCV2973	COG5002	protein histidine kinase activity
XCV2973	COG5001	Diguanylate cyclase
XCV2995	COG0667	Aldo Keto reductase
XCV2996	COG2814	Major facilitator Superfamily
XCV2997	COG0583	DNA-binding transcription factor activity
XCV2998	COG2207	Transcriptional regulator
XCV3001	COG1309	transcriptional regulator
XCV3002	COG1538	Outer membrane efflux protein
XCV3006	COG0735	belongs to the Fur family
XCV3007	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XCV3012	COG4452	Inner membrane protein CreD
XCV3014	COG2205	protein histidine kinase activity
XCV3015	COG0745	RESPONSE REGULATOR receiver
XCV3016	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XCV3018	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XCV3020	COG2198	Histidine kinase
XCV3020	COG0643	Histidine kinase
XCV3021	COG0840	transmembrane signaling receptor activity
XCV3022	COG0835	chemotaxis
XCV3023	COG2199	diguanylate cyclase activity
XCV3023	COG2200	EAL domain
XCV3023	COG2202	Pas domain
XCV3024	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XCV3025	COG2201	protein-glutamate methylesterase activity
XCV3026	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCV3027	COG3590	peptidase
XCV3029	COG0588	phosphoglycerate mutase activity
XCV3030	COG1515	deoxyribonuclease V activity
XCV3032	COG1741	Belongs to the pirin family
XCV3035	COG1741	Belongs to the pirin family
XCV3036	COG1966	Carbon starvation protein
XCV3043	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
XCV3044	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XCV3045	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XCV3046	COG2080	2 iron, 2 sulfur cluster binding
XCV3047	COG0604	alcohol dehydrogenase
XCV3047	COG3321	synthase
XCV3047	COG1028	Short-chain dehydrogenase reductase Sdr
XCV3048	COG2203	Gaf domain
XCV3048	COG5001	Diguanylate cyclase
XCV3048	COG4251	negative regulation of phosphorylation
XCV3048	COG3706	GGDEF domain
XCV3049	COG0629	single-stranded DNA binding
XCV3050	COG0142	geranyltranstransferase activity
XCV3053	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XCV3056	COG0527	aspartate kinase activity
XCV3057	COG0384	phenazine biosynthesis protein PhzF
XCV3058	COG0384	phenazine biosynthesis protein PhzF
XCV3060	COG1764	response to oxidative stress
XCV3061	COG0540	Belongs to the ATCase OTCase family
XCV3062	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XCV3063	COG1678	Uncharacterized ACR, COG1678
XCV3064	COG0519	Catalyzes the synthesis of GMP from XMP
XCV3069	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XCV3072	COG0739	heme binding
XCV3076	COG0693	protein deglycase activity
XCV3078	COG1959	2 iron, 2 sulfur cluster binding
XCV3079	COG0719	Fe-S assembly protein
XCV3080	COG0396	ATPase activity
XCV3081	COG0719	Fe-S assembly protein
XCV3082	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XCV3085	COG4774	siderophore transport
XCV3086	COG3128	pkhd-type hydroxylase
XCV3091	COG1477	protein flavinylation
XCV3092	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XCV3096	COG1555	photosystem II stabilization
XCV3100	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XCV3102	COG0628	permease
XCV3104	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XCV3106	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XCV3110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XCV3112	COG0271	Belongs to the BolA IbaG family
XCV3114	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XCV3116	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XCV3117	COG1137	ATPase activity
XCV3120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XCV3121	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XCV3122	COG1660	Displays ATPase and GTPase activities
XCV3124	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XCV3125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XCV3126	COG2239	Acts as a magnesium transporter
XCV3128	COG1294	oxidase, subunit
XCV3129	COG1271	oxidase subunit
XCV3131	COG1113	amino acid transport
XCV3135	COG2197	response regulator
XCV3136	COG0531	amino acid
XCV3150	COG2814	Major facilitator Superfamily
XCV3152	COG0754	glutathionylspermidine amidase activity
XCV3157	COG1842	Phage shock protein A
XCV3159	COG0259	pyridoxamine-phosphate oxidase activity
XCV3160	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XCV3161	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XCV3163	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XCV3164	COG2814	Major facilitator Superfamily
XCV3169	COG2353	YceI-like domain
XCV3173	COG1760	l-serine dehydratase
XCV3175	COG0527	aspartate kinase activity
XCV3175	COG0460	homoserine dehydrogenase
XCV3176	COG0626	cystathionine gamma-synthase activity
XCV3177	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XCV3178	COG0739	heme binding
XCV3179	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XCV3180	COG1272	protein, Hemolysin III
XCV3181	COG2982	Protein involved in outer membrane biogenesis
XCV3182	COG0517	IMP dehydrogenase activity
XCV3182	COG0516	GMP reductase activity
XCV3183	COG0463	Glycosyl transferase, family 2
XCV3184	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XCV3185	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XCV3188	COG1309	transcriptional regulator
XCV3189	COG2267	carboxylic ester hydrolase activity
XCV3190	COG1960	acyl-CoA dehydrogenase activity
XCV3195	COG0509	glycine decarboxylation via glycine cleavage system
XCV3196	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XCV3197	COG0330	HflC and HflK could
XCV3198	COG1742	UPF0060 membrane protein
XCV3199	COG3956	TIGRFAM MazG family protein
XCV3201	COG0494	nUDIX hydrolase
XCV3203	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XCV3204	COG0837	glucose binding
XCV3208	COG1388	LysM domain
XCV3208	COG3858	chitin binding
XCV3209	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XCV3211	COG1472	Belongs to the glycosyl hydrolase 3 family
XCV3213	COG3537	Alpha-1,2-mannosidase
XCV3221	COG3142	Participates in the control of copper homeostasis
XCV3222	COG1446	asparaginase
XCV3223	COG2304	oxidoreductase activity
XCV3224	COG1595	DNA-templated transcription, initiation
XCV3230	COG0840	transmembrane signaling receptor activity
XCV3231	COG0835	chemotaxis
XCV3234	COG0189	ligase activity
XCV3237	COG1397	ADP-ribosylglycohydrolase
XCV3239	COG1199	ATP-dependent helicase activity
XCV3241	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XCV3242	COG1215	transferase activity, transferring glycosyl groups
XCV3244	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XCV3245	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
XCV3246	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
XCV3247	COG0535	radical SAM domain protein
XCV3248	COG0535	radical SAM domain protein
XCV3251	COG0837	glucose binding
XCV3253	COG1643	Atp-dependent helicase
XCV3254	COG0783	Belongs to the Dps family
XCV3255	COG0514	ATP-dependent DNA helicase (RecQ)
XCV3259	COG1187	pseudouridine synthase activity
XCV3261	COG0840	transmembrane signaling receptor activity
XCV3267	COG3920	Histidine kinase
XCV3268	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XCV3269	COG0602	queuosine metabolic process
XCV3271	COG2885	chlorophyll binding
XCV3272	COG0823	Involved in the tonB-independent uptake of proteins
XCV3274	COG0848	biopolymer transport protein
XCV3276	COG0824	Thioesterase
XCV3277	COG2255	four-way junction helicase activity
XCV3279	COG3158	transport of potassium into the cell
XCV3280	COG0632	four-way junction helicase activity
XCV3281	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XCV3282	COG0217	transcriptional regulatory protein
XCV3286	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XCV3289	COG0477	Major facilitator Superfamily
XCV3292	COG0657	acetylesterase activity
XCV3292	COG2755	lipolytic protein G-D-S-L family
XCV3296	COG0488	(ABC) transporter
XCV3303	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XCV3303	COG4651	solute:proton antiporter activity
XCV3304	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XCV3304	COG4651	solute:proton antiporter activity
XCV3306	COG4772	TonB-dependent receptor
XCV3308	COG4264	IucA IucC family
XCV3309	COG2814	Major facilitator Superfamily
XCV3311	COG0019	diaminopimelate decarboxylase activity
XCV3315	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XCV3317	COG1492	cobalamin metabolic process
XCV3319	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XCV3323	COG4206	TonB-dependent receptor
XCV3324	COG0542	response to heat
XCV3325	COG1116	anion transmembrane transporter activity
XCV3333	COG4771	TonB-dependent receptor
XCV3334	COG1877	trehalose-phosphatase activity
XCV3335	COG3387	PFAM Glycoside hydrolase 15-related
XCV3338	COG0840	transmembrane signaling receptor activity
XCV3339	COG3011	Protein conserved in bacteria
XCV3342	COG0564	pseudouridine synthase activity
XCV3343	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XCV3345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XCV3345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XCV3348	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XCV3349	COG0045	succinate-CoA ligase (ADP-forming) activity
XCV3353	COG4969	Belongs to the N-Me-Phe pilin family
XCV3355	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XCV3356	COG0237	dephospho-CoA kinase activity
XCV3359	COG2963	transposase activity
XCV3362	COG2963	transposase activity
XCV3363	COG2801	Transposase and inactivated derivatives
XCV3365	COG0745	RESPONSE REGULATOR receiver
XCV3367	COG0189	ligase activity
XCV3383	COG2801	Transposase and inactivated derivatives
XCV3386	COG2963	transposase activity
XCV3395	COG3039	Transposase
XCV3398	COG2801	Transposase and inactivated derivatives
XCV3400	COG3220	belongs to the UPF0276 family
XCV3402	COG0688	phosphatidylethanolamine metabolic process
XCV3403	COG0688	phosphatidylethanolamine metabolic process
XCV3404	COG2003	Belongs to the UPF0758 family
XCV3409	COG2801	Transposase and inactivated derivatives
XCV3417	COG2022	thiamine diphosphate biosynthetic process
XCV3418	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XCV3419	COG0471	metal ion transport
XCV3419	COG3273	potassium ion transport
XCV3424	COG1970	mechanosensitive ion channel activity
XCV3427	COG1609	Transcriptional regulator
XCV3430	COG3250	beta-galactosidase activity
XCV3431	COG4948	Mandelate Racemase Muconate Lactonizing
XCV3434	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XCV3437	COG0308	aminopeptidase N
XCV3443	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCV3445	COG0529	Catalyzes the synthesis of activated sulfate
XCV3445	COG2895	sulfate adenylyltransferase (ATP) activity
XCV3446	COG0175	sulfate reduction
XCV3447	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XCV3448	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XCV3449	COG0175	sulfate reduction
XCV3458	COG1648	precorrin-2 dehydrogenase activity
XCV3458	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XCV3461	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
XCV3462	COG3588	fructose-bisphosphate aldolase
XCV3463	COG0469	pyruvate kinase activity
XCV3465	COG0126	phosphoglycerate kinase activity
XCV3469	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XCV3471	COG3047	cAMP biosynthetic process
XCV3472	COG3047	cAMP biosynthetic process
XCV3474	COG3453	Protein conserved in bacteria
XCV3474	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XCV3475	COG0725	ABC transporter, periplasmic molybdate-binding protein
XCV3476	COG4149	molybdate abc transporter
XCV3477	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XCV3486	COG1376	ErfK ybiS ycfS ynhG family protein
XCV3487	COG0739	heme binding
XCV3489	COG4773	Receptor
XCV3490	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XCV3491	COG1301	dicarboxylic acid transport
XCV3493	COG2304	oxidoreductase activity
XCV3496	COG0714	Associated with various cellular activities
XCV3502	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XCV3506	COG0254	rRNA binding
XCV3507	COG1957	nucleoside hydrolase
XCV3508	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XCV3510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XCV3511	COG1758	RNA polymerase activity
XCV3512	COG0194	GDP metabolic process
XCV3513	COG1561	YicC-like family, N-terminal region
XCV3514	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XCV3516	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XCV3517	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XCV3520	COG0006	proline dipeptidase activity
XCV3522	COG0006	proline dipeptidase activity
XCV3523	COG3079	Belongs to the UPF0149 family
XCV3526	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XCV3528	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XCV3530	COG2912	Transglutaminase-like superfamily
XCV3531	COG1773	rubredoxin
XCV3532	COG0352	thiamine-phosphate diphosphorylase activity
XCV3535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XCV3537	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
XCV3538	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XCV3544	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XCV3545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XCV3546	COG1028	Short-chain dehydrogenase reductase Sdr
XCV3548	COG0671	phosphoesterase, PA-phosphatase related
XCV3549	COG3781	membrane
XCV3552	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XCV3553	COG0563	adenylate kinase activity
XCV3568	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XCV3570	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XCV3574	COG3710	Transcriptional regulator
XCV3575	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XCV3577	COG0840	transmembrane signaling receptor activity
XCV3578	COG0405	Gamma-glutamyltransferase
XCV3579	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XCV3583	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XCV3584	COG0473	3-isopropylmalate dehydrogenase activity
XCV3585	COG0066	3-isopropylmalate dehydratase activity
XCV3586	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XCV3590	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XCV3591	COG1538	Outer membrane efflux protein
XCV3592	COG1519	Transferase
XCV3593	COG1560	Kdo2-lipid A biosynthetic process
XCV3598	COG0281	malic enzyme
XCV3598	COG0280	phosphate acetyltransferase
XCV3599	COG1301	dicarboxylic acid transport
XCV3604	COG0583	DNA-binding transcription factor activity
XCV3605	COG0667	Aldo Keto reductase
XCV3608	COG2197	response regulator
XCV3609	COG1840	ABC-type Fe3 transport system, periplasmic component
XCV3610	COG0642	Histidine kinase
XCV3613	COG2851	Citrate transporter
XCV3614	COG1028	Short-chain dehydrogenase reductase Sdr
XCV3615	COG1609	Transcriptional regulator
XCV3616	COG2211	Major facilitator Superfamily
XCV3621	COG1162	GTPase activity
XCV3625	COG0726	polysaccharide deacetylase
XCV3626	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XCV3629	COG3964	amidohydrolase
XCV3630	COG0402	S-adenosylhomocysteine deaminase activity
XCV3635	COG1307	EDD domain protein, DegV family
XCV3636	COG0242	peptide deformylase activity
XCV3640	COG0457	Tetratricopeptide repeat
XCV3641	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
XCV3642	COG1215	transferase activity, transferring glycosyl groups
XCV3643	COG1215	transferase activity, transferring glycosyl groups
XCV3644	COG1215	transferase activity, transferring glycosyl groups
XCV3647	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XCV3658	COG1450	Type ii and iii secretion system protein
XCV3661	COG3166	PFAM Fimbrial assembly family protein
XCV3662	COG3156	type II secretion system protein K
XCV3663	COG4795	General secretion pathway protein
XCV3664	COG2165	general secretion pathway protein
XCV3665	COG4970	Tfp pilus assembly protein FimT
XCV3666	COG2165	general secretion pathway protein
XCV3667	COG1459	type II secretion system
XCV3668	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XCV3669	COG1404	Belongs to the peptidase S8 family
XCV3670	COG5295	Hep Hag repeat protein
XCV3671	COG1404	Belongs to the peptidase S8 family
XCV3672	COG5295	Hep Hag repeat protein
XCV3674	COG0047	phosphoribosylformylglycinamidine synthase activity
XCV3674	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XCV3675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XCV3676	COG4974	Belongs to the 'phage' integrase family
XCV3679	COG0795	lipopolysaccharide-transporting ATPase activity
XCV3681	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XCV3684	COG0525	valine-tRNA ligase activity
XCV3690	COG1183	phosphatidylcholine synthase activity
XCV3692	COG0442	prolyl-tRNA aminoacylation
XCV3695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XCV3696	COG1127	ABC transporter
XCV3697	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XCV3697	COG3218	ABC-type transport auxiliary lipoprotein component
XCV3702	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XCV3703	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XCV3704	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XCV3704	COG0662	Cupin 2, conserved barrel domain protein
XCV3710	COG2086	electron transfer activity
XCV3713	COG0463	Glycosyl transferase, family 2
XCV3718	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
XCV3719	COG0438	transferase activity, transferring glycosyl groups
XCV3723	COG0438	transferase activity, transferring glycosyl groups
XCV3725	COG0626	cystathionine gamma-synthase activity
XCV3731	COG0625	glutathione transferase activity
XCV3733	COG0513	Belongs to the DEAD box helicase family
XCV3734	COG0720	synthase
XCV3736	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XCV3737	COG1956	GAF domain-containing protein
XCV3740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XCV3741	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XCV3744	COG0339	signal peptide processing
XCV3754	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XCV3755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCV3756	COG1136	(ABC) transporter
XCV3757	COG0577	efflux transmembrane transporter activity
XCV3760	COG2204	response regulator
XCV3761	COG4191	Histidine kinase
XCV3762	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XCV3766	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XCV3767	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XCV3768	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XCV3769	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XCV3770	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XCV3771	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XCV3773	COG0356	it plays a direct role in the translocation of protons across the membrane
XCV3777	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XCV3779	COG0508	dehydrogenase complex catalyzes the overall conversion of
XCV3788	COG2011	ABC-type metal ion transport system permease component
XCV3789	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XCV3790	COG0697	spore germination
XCV3791	COG1666	GTP binding
XCV3793	COG2198	Histidine kinase
XCV3793	COG0784	Response regulator, receiver
XCV3793	COG5002	protein histidine kinase activity
XCV3798	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XCV3799	COG1187	pseudouridine synthase activity
XCV3800	COG2813	Specifically methylates the guanine in position
XCV3804	COG2205	protein histidine kinase activity
XCV3804	COG2202	Pas domain
XCV3808	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XCV3809	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCV3810	COG1522	sequence-specific DNA binding
XCV3821	COG0842	Transport permease protein
XCV3822	COG1131	(ABC) transporter
XCV3823	COG0025	NhaP-type Na H and K H
XCV3824	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XCV3825	COG1573	uracil-dna glycosylase
XCV3827	COG3384	dioxygenase
XCV3828	COG0583	DNA-binding transcription factor activity
XCV3830	COG0667	Aldo Keto reductase
XCV3834	COG3590	peptidase
XCV3837	COG0531	amino acid
XCV3840	COG2972	Histidine kinase
XCV3844	COG3685	Protein conserved in bacteria
XCV3845	COG3546	catalase activity
XCV3854	COG1271	oxidase subunit
XCV3855	COG1294	oxidase, subunit
XCV3858	COG1028	Short-chain dehydrogenase reductase Sdr
XCV3859	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XCV3863	COG1132	(ABC) transporter
XCV3866	COG1063	alcohol dehydrogenase
XCV3881	COG0251	oxidation-reduction process
XCV3884	COG0583	DNA-binding transcription factor activity
XCV3885	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XCV3891	COG0659	secondary active sulfate transmembrane transporter activity
XCV3892	COG0038	chloride channel
XCV3894	COG0024	Methionine aminopeptidase
XCV3897	COG1028	Short-chain dehydrogenase reductase Sdr
XCV3906	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XCV3912	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XCV3913	COG1490	D-aminoacyl-tRNA deacylase activity
XCV3914	COG1560	Kdo2-lipid A biosynthetic process
XCV3924	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XCV3924	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XCV3925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XCV3926	COG0242	peptide deformylase activity
XCV3927	COG1652	LysM domain
XCV3928	COG0758	DNA mediated transformation
XCV3929	COG2922	Belongs to the Smg family
XCV3932	COG1754	DNA topoisomerase type I activity
XCV3932	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XCV3933	COG0009	L-threonylcarbamoyladenylate synthase
XCV3936	COG1028	Short-chain dehydrogenase reductase Sdr
XCV3938	COG0616	signal peptide processing
XCV3939	COG0534	Mate efflux family protein
XCV3943	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XCV3947	COG1252	NADH dehydrogenase
XCV3948	COG2860	membrane
XCV3949	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XCV3950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XCV3951	COG2201	protein-glutamate methylesterase activity
XCV3952	COG2177	Part of the ABC transporter FtsEX involved in
XCV3953	COG2884	Cell division ATP-binding protein ftsE
XCV3954	COG0513	Belongs to the DEAD box helicase family
XCV3955	COG3118	belongs to the thioredoxin family
XCV3956	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XCV3958	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XCV3959	COG0583	DNA-binding transcription factor activity
XCV3962	COG1652	LysM domain
XCV3963	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XCV3963	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XCV3964	COG1473	amidohydrolase
XCV3965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCV3966	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCV3968	COG5383	Protein conserved in bacteria
XCV3977	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
XCV3978	COG3023	N-Acetylmuramoyl-L-alanine amidase
XCV3980	COG4948	Mandelate Racemase Muconate Lactonizing
XCV3982	COG0531	amino acid
XCV3986	COG4682	membrane
XCV3987	COG2133	pyrroloquinoline quinone binding
XCV3989	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XCV3990	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XCV3991	COG0828	Belongs to the bacterial ribosomal protein bS21 family
XCV3992	COG1610	YqeY-like protein
XCV3993	COG1295	ribonuclease BN
XCV3994	COG0358	DNA primase activity
XCV3997	COG0109	protoheme IX farnesyltransferase activity
XCV4003	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XCV4006	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XCV4010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XCV4011	COG0739	heme binding
XCV4012	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XCV4014	COG2223	nitrite transmembrane transporter activity
XCV4015	COG0708	Exodeoxyribonuclease III
XCV4016	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XCV4018	COG1192	Involved in chromosome partitioning
XCV4019	COG1475	DNA binding
XCV4022	COG0463	Glycosyl transferase, family 2
XCV4026	COG0756	dUTP diphosphatase activity
XCV4027	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XCV4028	COG2003	Belongs to the UPF0758 family
XCV4029	COG0018	arginyl-trna synthetase
XCV4032	COG4221	oxidoreductase activity
XCV4035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XCV4036	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XCV4038	COG1166	arginine decarboxylase activity
XCV4039	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XCV4043	COG3291	Pkd domain containing protein
XCV4043	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XCV4047	COG0606	chelatase, subunit chli
XCV4051	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XCV4058	COG1690	Belongs to the RtcB family
XCV4067	COG1090	epimerase
XCV4068	COG0745	RESPONSE REGULATOR receiver
XCV4069	COG0642	Histidine kinase
XCV4074	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XCV4078	COG0628	permease
XCV4079	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XCV4080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XCV4083	COG0753	catalase activity
XCV4086	COG2197	response regulator
XCV4087	COG4585	Histidine kinase
XCV4088	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCV4089	COG1136	(ABC) transporter
XCV4094	COG0697	spore germination
XCV4097	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XCV4098	COG0180	Tryptophanyl-tRNA synthetase
XCV4099	COG3237	CsbD-like
XCV4107	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XCV4109	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XCV4110	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XCV4110	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XCV4115	COG2205	protein histidine kinase activity
XCV4116	COG0745	RESPONSE REGULATOR receiver
XCV4118	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XCV4123	COG1199	ATP-dependent helicase activity
XCV4126	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XCV4137	COG0625	glutathione transferase activity
XCV4144	COG4555	ABC transporter
XCV4146	COG1476	TRANSCRIPTIONal
XCV4151	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XCV4152	COG1131	(ABC) transporter
XCV4153	COG0842	Transport permease protein
XCV4154	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XCV4159	COG0716	FMN binding
XCV4160	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XCV4161	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XCV4163	COG1042	CoA-binding domain protein
XCV4163	COG0045	succinate-CoA ligase (ADP-forming) activity
XCV4163	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XCV4164	COG2239	Acts as a magnesium transporter
XCV4168	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XCV4169	COG3387	PFAM Glycoside hydrolase 15-related
XCV4171	COG3100	YcgL domain-containing protein
XCV4172	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XCV4174	COG0463	Glycosyl transferase, family 2
XCV4176	COG3039	Transposase
XCV4178	COG1028	Short-chain dehydrogenase reductase Sdr
XCV4186	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XCV4189	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XCV4198	COG0408	coproporphyrinogen oxidase activity
XCV4206	COG0515	serine threonine protein kinase
XCV4207	COG0631	protein serine/threonine phosphatase activity
XCV4212	COG0667	Aldo Keto reductase
XCV4213	COG0583	DNA-binding transcription factor activity
XCV4217	COG3501	Rhs element vgr protein
XCV4234	COG2963	transposase activity
XCV4248	COG0210	DNA helicase
XCV4251	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCV4252	COG0583	DNA-binding transcription factor activity
XCV4253	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XCV4255	COG2159	amidohydrolase
XCV4256	COG0267	Belongs to the bacterial ribosomal protein bL33 family
XCV4257	COG0227	Belongs to the bacterial ribosomal protein bL28 family
XCV4260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCV4264	COG0357	Ribosomal RNA small subunit methyltransferase G
XCV4265	COG3540	Alkaline phosphatase
XCV4267	COG2091	lysine biosynthetic process via aminoadipic acid
XCV4270	COG0708	Exodeoxyribonuclease III
XCV4272	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XCV4273	COG3162	membrane
XCV4275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XCV4281	COG3507	Belongs to the glycosyl hydrolase 43 family
XCV4284	COG1028	Short-chain dehydrogenase reductase Sdr
XCV4285	COG0179	Fumarylacetoacetate (FAA) hydrolase
XCV4287	COG4948	Mandelate Racemase Muconate Lactonizing
XCV4288	COG3254	rhamnose metabolic process
XCV4289	COG0738	Major facilitator superfamily
XCV4290	COG1414	Transcriptional regulator
XCV4291	COG1971	Probably functions as a manganese efflux pump
XCV4292	COG2205	protein histidine kinase activity
XCV4295	COG3459	Glycosyltransferase 36 associated
XCV4296	COG2211	Major facilitator Superfamily
XCV4297	COG3265	gluconokinase activity
XCV4300	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XCV4305	COG2911	Protein conserved in bacteria
XCV4306	COG0729	surface antigen
XCV4307	COG4771	TonB-dependent receptor
XCV4309	COG0457	Tetratricopeptide repeat
XCV4311	COG0752	glycyl-tRNA synthetase alpha subunit
XCV4312	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XCV4317	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XCV4317	COG0519	Catalyzes the synthesis of GMP from XMP
XCV4319	COG0805	protein transport
XCV4320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XCV4321	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XCV4323	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XCV4327	COG2974	May be involved in recombination
XCV4328	COG0037	tRNA processing
XCV4330	COG2115	Belongs to the xylose isomerase family
XCV4333	COG3661	Belongs to the glycosyl hydrolase 67 family
XCV4335	COG4948	Mandelate Racemase Muconate Lactonizing
XCV4337	COG1472	Belongs to the glycosyl hydrolase 3 family
XCV4338	COG0246	Mannitol dehydrogenase
XCV4348	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XCV4353	COG3386	PFAM SMP-30 Gluconolaconase
XCV4356	COG3250	beta-galactosidase activity
XCV4357	COG1904	glucuronate isomerase
XCV4358	COG3693	PFAM glycoside hydrolase, family 10
XCV4360	COG3693	PFAM glycoside hydrolase, family 10
XCV4363	COG2211	Major facilitator Superfamily
XCV4370	COG3321	synthase
XCV4370	COG1028	Short-chain dehydrogenase reductase Sdr
XCV4370	COG0604	alcohol dehydrogenase
XCV4371	COG2937	Belongs to the GPAT DAPAT family
XCV4378	COG0284	orotidine-5'-phosphate decarboxylase activity
XCV4379	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
XCV4380	COG3132	Protein of unknown function, DUF480
XCV4383	COG0210	DNA helicase
XCV4384	COG1435	thymidine kinase activity
XCV4387	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XCV4390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XCV4391	COG3135	benzoate transporter
XCV4395	COG0676	glucose-6-phosphate 1-epimerase activity
XCV4397	COG3012	SEC-C Motif Domain Protein
XCV4398	COG0730	response to heat
XCV4402	COG0302	gtp cyclohydrolase
XCV4405	COG1566	PFAM secretion protein HlyD family protein
XCV4407	COG1289	transmembrane transporter activity
XCV4408	COG0477	Major facilitator Superfamily
XCV4412	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCV4422	COG0564	pseudouridine synthase activity
XCV4432	COG1309	transcriptional regulator
XCV4434	COG1028	Short-chain dehydrogenase reductase Sdr
XCV4441	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XCV4442	COG1074	ATP-dependent DNA helicase activity
XCV4443	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XCV4450	COG1127	ABC transporter
XCV4451	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XCV4452	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XCV4455	COG2853	Lipoprotein
XCV4457	COG0386	Belongs to the glutathione peroxidase family
XCV4459	COG1322	Protein conserved in bacteria
XCV4460	COG0604	alcohol dehydrogenase
XCV4461	COG0583	DNA-binding transcription factor activity
XCV4466	COG0531	amino acid
XCV4467	COG3537	Alpha-1,2-mannosidase
XCV4468	COG4206	TonB-dependent receptor
XCV4470	COG3706	GGDEF domain
XCV4471	COG3835	regulator
XCV4472	COG1929	Belongs to the glycerate kinase type-1 family
XCV4473	COG2271	Major facilitator Superfamily
XCV4476	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XCV4477	COG0861	Integral membrane protein TerC family
XCV4479	COG0584	glycerophosphoryl diester phosphodiesterase
XCV4483	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XCV4484	COG0726	polysaccharide deacetylase
XCV4485	COG0706	membrane insertase activity
XCV4486	COG0594	ribonuclease P activity
XCV4487	COG0230	Belongs to the bacterial ribosomal protein bL34 family
XCVb0011	COG2801	Transposase and inactivated derivatives
XCVb0013	COG3318	Belongs to the UPF0149 family
XCVb0013	COG3012	SEC-C Motif Domain Protein
XCVb0018	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XCVc0002	COG2337	Toxic component of a toxin-antitoxin (TA) module
XCVc0009	COG3328	transposase activity
XCVc0026	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCVc0030	COG2948	multi-organism process
XCVc0031	COG3504	Conjugal transfer protein
XCVc0033	COG3704	protein secretion by the type IV secretion system
XCVc0036	COG3012	SEC-C Motif Domain Protein
XCVc0036	COG3318	Belongs to the UPF0149 family
XCVc0040	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XCVd0001	COG1192	Involved in chromosome partitioning
XCVd0002	COG1475	DNA binding
XCVd0014	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XCVd0021	COG3039	Transposase
XCVd0025	COG2963	transposase activity
XCVd0026	COG3039	Transposase
XCVd0036	COG1754	DNA topoisomerase type I activity
XCVd0036	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XCVd0049	COG0305	Participates in initiation and elongation during chromosome replication
XCVd0072	COG0653	protein targeting
XCVd0074	COG0464	growth
XCVd0079	COG0210	DNA helicase
XCVd0090	COG2963	transposase activity
XCVd0102	COG4456	Virulence-associated protein
XCVd0103	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XCVd0105	COG5599	Phosphatase
XCVd0109	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XCVd0113	COG3012	SEC-C Motif Domain Protein
XCVd0113	COG3318	Belongs to the UPF0149 family
XCVd0128	COG0776	regulation of translation
XCVd0134	COG2974	May be involved in recombination
XCVd0137	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XCVd0150	COG3287	FIST C domain
XCVd0150	COG2200	EAL domain
XCVd0150	COG2199	diguanylate cyclase activity
XCVd0152	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone