locus-tag	class	description
DGM98_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DGM98_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DGM98_00025	COG0187	DNA topoisomerase II activity
DGM98_00035	COG0501	Belongs to the peptidase M48B family
DGM98_00070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DGM98_00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGM98_00130	COG0793	Belongs to the peptidase S41A family
DGM98_00135	COG4942	peptidase
DGM98_00145	COG2234	aminopeptidase activity
DGM98_00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGM98_00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGM98_00165	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGM98_00175	COG1064	alcohol dehydrogenase
DGM98_00190	COG0493	'glutamate synthase
DGM98_00195	COG0070	glutamate synthase
DGM98_00195	COG0069	glutamate synthase activity
DGM98_00195	COG0067	glutamate synthase
DGM98_00285	COG1111	helicase
DGM98_00285	COG1205	dead DEAH box helicase
DGM98_00290	COG1272	protein, Hemolysin III
DGM98_00310	COG0300	oxidoreductase activity
DGM98_00315	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_00340	COG2249	NAD(P)H dehydrogenase (quinone) activity
DGM98_00370	COG3237	CsbD-like
DGM98_00420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGM98_00430	COG0477	Major facilitator Superfamily
DGM98_00475	COG0714	Associated with various cellular activities
DGM98_00520	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DGM98_00530	COG4772	TonB-dependent receptor
DGM98_00545	COG1012	belongs to the aldehyde dehydrogenase family
DGM98_00570	COG1304	FMN binding
DGM98_00585	COG4585	Histidine kinase
DGM98_00590	COG2197	response regulator
DGM98_00610	COG3710	Transcriptional regulator
DGM98_00615	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DGM98_00710	COG3328	transposase activity
DGM98_00770	COG0366	Alpha amylase catalytic
DGM98_00775	COG0366	Alpha amylase catalytic
DGM98_00780	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGM98_00800	COG2755	lipolytic protein G-D-S-L family
DGM98_00800	COG0657	acetylesterase activity
DGM98_00810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DGM98_00825	COG3507	Belongs to the glycosyl hydrolase 43 family
DGM98_00830	COG1609	Transcriptional regulator
DGM98_00840	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DGM98_00845	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_00855	COG2755	lipolytic protein G-D-S-L family
DGM98_00865	COG3186	Phenylalanine-4-hydroxylase
DGM98_00870	COG1522	sequence-specific DNA binding
DGM98_00880	COG1752	Esterase of the alpha-beta hydrolase superfamily
DGM98_00890	COG1119	ATPase activity
DGM98_00905	COG1125	glycine betaine transport
DGM98_00920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DGM98_00950	COG0489	protein tyrosine kinase activity
DGM98_00955	COG2062	phosphohistidine phosphatase, SixA
DGM98_00965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGM98_01010	COG1968	undecaprenyl-diphosphatase activity
DGM98_01020	COG0174	glutamine synthetase
DGM98_01025	COG0347	Belongs to the P(II) protein family
DGM98_01030	COG0004	ammonium transporteR
DGM98_01035	COG3852	Histidine kinase
DGM98_01040	COG2204	response regulator
DGM98_01045	COG2032	superoxide dismutase activity
DGM98_01050	COG2032	superoxide dismutase activity
DGM98_01055	COG0346	lactoylglutathione lyase activity
DGM98_01065	COG0183	Belongs to the thiolase family
DGM98_01100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DGM98_01105	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DGM98_01110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DGM98_01125	COG0028	Belongs to the TPP enzyme family
DGM98_01130	COG2205	protein histidine kinase activity
DGM98_01155	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DGM98_01170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGM98_01180	COG0596	Alpha beta hydrolase
DGM98_01185	COG0727	PFAM Uncharacterised protein family (UPF0153)
DGM98_01190	COG0318	PFAM AMP-dependent synthetase and ligase
DGM98_01195	COG0745	RESPONSE REGULATOR receiver
DGM98_01205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGM98_01235	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DGM98_01245	COG0564	pseudouridine synthase activity
DGM98_01265	COG1446	asparaginase
DGM98_01270	COG0339	signal peptide processing
DGM98_01310	COG0475	glutathione-regulated potassium exporter activity
DGM98_01315	COG0583	DNA-binding transcription factor activity
DGM98_01320	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DGM98_01325	COG2224	Isocitrate lyase
DGM98_01355	COG4770	biotin carboxylase activity
DGM98_01360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DGM98_01365	COG1960	acyl-CoA dehydrogenase activity
DGM98_01435	COG0697	spore germination
DGM98_01445	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DGM98_01450	COG1846	Transcriptional regulator
DGM98_01455	COG1764	response to oxidative stress
DGM98_01485	COG2130	NADP-dependent
DGM98_01500	COG1187	pseudouridine synthase activity
DGM98_01515	COG1643	Atp-dependent helicase
DGM98_01525	COG4807	Protein conserved in bacteria
DGM98_01530	COG2351	hydroxyisourate hydrolase activity
DGM98_01535	COG2072	flavoprotein involved in K transport
DGM98_01555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DGM98_01565	COG0583	DNA-binding transcription factor activity
DGM98_01600	COG2252	PERMEase
DGM98_01625	COG0084	hydrolase, TatD family'
DGM98_01635	COG0583	DNA-binding transcription factor activity
DGM98_01640	COG2814	Major facilitator Superfamily
DGM98_01650	COG2267	carboxylic ester hydrolase activity
DGM98_01655	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DGM98_01660	COG1902	pentaerythritol trinitrate reductase activity
DGM98_01680	COG0745	RESPONSE REGULATOR receiver
DGM98_01685	COG2205	protein histidine kinase activity
DGM98_01690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGM98_01715	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DGM98_01720	COG0583	DNA-binding transcription factor activity
DGM98_01750	COG0702	epimerase
DGM98_01755	COG1733	regulation of RNA biosynthetic process
DGM98_01795	COG0129	dihydroxy-acid dehydratase activity
DGM98_01810	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DGM98_01865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DGM98_01870	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DGM98_01895	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DGM98_01900	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DGM98_01910	COG3485	protocatechuate 3,4-dioxygenase
DGM98_01915	COG3485	protocatechuate 3,4-dioxygenase
DGM98_01925	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGM98_01930	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DGM98_01940	COG1414	Transcriptional regulator
DGM98_01950	COG0657	acetylesterase activity
DGM98_01960	COG0445	tRNA wobble uridine modification
DGM98_01970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DGM98_01995	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_02000	COG2267	carboxylic ester hydrolase activity
DGM98_02010	COG0156	8-amino-7-oxononanoate synthase activity
DGM98_02015	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DGM98_02020	COG1040	competence protein
DGM98_02025	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DGM98_02070	COG5297	Belongs to the glycosyl hydrolase family 6
DGM98_02120	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DGM98_02195	COG1511	domain protein
DGM98_02195	COG3264	Mechanosensitive ion channel
DGM98_02200	COG1368	sulfuric ester hydrolase activity
DGM98_02210	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DGM98_02215	COG2354	Protein conserved in bacteria
DGM98_02225	COG0297	glycogen (starch) synthase activity
DGM98_02230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGM98_02235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGM98_02260	COG0702	epimerase
DGM98_02265	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_02300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGM98_02305	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_02315	COG0513	Belongs to the DEAD box helicase family
DGM98_02325	COG0508	dehydrogenase complex catalyzes the overall conversion of
DGM98_02340	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DGM98_02355	COG3483	tryptophan 2,3-dioxygenase activity
DGM98_02360	COG3104	oligopeptide transport
DGM98_02380	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DGM98_02400	COG1320	monovalent cation:proton antiporter activity
DGM98_02405	COG2212	antiporter activity
DGM98_02415	COG0651	ATP synthesis coupled electron transport
DGM98_02420	COG1006	Multisubunit Na H antiporter MnhC subunit
DGM98_02425	COG2111	Na H antiporter
DGM98_02425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DGM98_02450	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DGM98_02455	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DGM98_02470	COG0456	acetyltransferase
DGM98_02475	COG1597	lipid kinase activity
DGM98_02505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DGM98_02510	COG0134	indole-3-glycerol-phosphate synthase activity
DGM98_02520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGM98_02525	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DGM98_02535	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DGM98_02545	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DGM98_02560	COG1051	belongs to the nudix hydrolase family
DGM98_02600	COG0316	Belongs to the HesB IscA family
DGM98_02615	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DGM98_02635	COG2814	Major facilitator Superfamily
DGM98_02645	COG2814	Major facilitator Superfamily
DGM98_02650	COG1289	transmembrane transporter activity
DGM98_02655	COG0151	Belongs to the GarS family
DGM98_02665	COG0138	bifunctional purine biosynthesis protein purh
DGM98_02670	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DGM98_02675	COG2267	carboxylic ester hydrolase activity
DGM98_02680	COG2453	phosphatase
DGM98_02680	COG0671	phosphoesterase, PA-phosphatase related
DGM98_02705	COG4589	Belongs to the CDS family
DGM98_02710	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DGM98_02735	COG2264	protein methyltransferase activity
DGM98_02755	COG0439	Biotin carboxylase
DGM98_02765	COG0511	ligase activity, forming carbon-carbon bonds
DGM98_02770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DGM98_02780	COG1324	tolerance protein
DGM98_02790	COG2356	endonuclease I
DGM98_02800	COG0459	protein refolding
DGM98_02815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DGM98_02830	COG3386	PFAM SMP-30 Gluconolaconase
DGM98_02840	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DGM98_02845	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DGM98_02870	COG0778	Nitroreductase
DGM98_02875	COG2353	YceI-like domain
DGM98_02905	COG3052	prosthetic group binding
DGM98_02930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DGM98_02940	COG1802	Transcriptional regulator
DGM98_03110	COG1082	Xylose isomerase domain protein TIM barrel
DGM98_03135	COG4221	oxidoreductase activity
DGM98_03150	COG4221	oxidoreductase activity
DGM98_03160	COG0435	Glutathione S-transferase
DGM98_03195	COG1506	peptidase
DGM98_03195	COG0823	Involved in the tonB-independent uptake of proteins
DGM98_03235	COG0697	spore germination
DGM98_03255	COG1113	amino acid transport
DGM98_03275	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DGM98_03325	COG0840	transmembrane signaling receptor activity
DGM98_03330	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGM98_03330	COG5297	Belongs to the glycosyl hydrolase family 6
DGM98_03335	COG0659	secondary active sulfate transmembrane transporter activity
DGM98_03360	COG2943	transferase activity, transferring hexosyl groups
DGM98_03370	COG3275	phosphorelay sensor kinase activity
DGM98_03380	COG0181	hydroxymethylbilane synthase activity
DGM98_03410	COG1505	serine-type exopeptidase activity
DGM98_03415	COG0436	Aminotransferase
DGM98_03425	COG2832	Protein of unknown function (DUF454)
DGM98_03435	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DGM98_03445	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DGM98_03450	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DGM98_03455	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DGM98_03480	COG2226	methyltransferase
DGM98_03485	COG5001	Diguanylate cyclase
DGM98_03485	COG3300	MHYT domain
DGM98_03490	COG0308	aminopeptidase N
DGM98_03540	COG3284	Transcriptional regulator
DGM98_03545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGM98_03550	COG1077	Cell shape determining protein MreB Mrl
DGM98_03555	COG1792	Involved in formation and maintenance of cell shape
DGM98_03570	COG0772	Belongs to the SEDS family
DGM98_03580	COG2951	lytic endotransglycosylase activity
DGM98_03585	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DGM98_03595	COG1686	Belongs to the peptidase S11 family
DGM98_03605	COG2921	Belongs to the UPF0250 family
DGM98_03610	COG0321	lipoyl(octanoyl) transferase activity
DGM98_03615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DGM98_03630	COG0583	DNA-binding transcription factor activity
DGM98_03640	COG1056	cytidyltransferase-related domain
DGM98_03640	COG1051	belongs to the nudix hydrolase family
DGM98_03675	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DGM98_03680	COG0673	inositol 2-dehydrogenase activity
DGM98_03685	COG2823	Periplasmic or secreted lipoprotein
DGM98_03690	COG4251	negative regulation of phosphorylation
DGM98_03695	COG0784	Response regulator, receiver
DGM98_03700	COG4191	Histidine kinase
DGM98_03705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DGM98_03765	COG1459	type II secretion system
DGM98_03770	COG2165	general secretion pathway protein
DGM98_03785	COG4795	General secretion pathway protein
DGM98_03815	COG3250	beta-galactosidase activity
DGM98_03830	COG2188	Transcriptional regulator
DGM98_03840	COG1609	Transcriptional regulator
DGM98_03845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DGM98_03850	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DGM98_03865	COG0617	tRNA 3'-terminal CCA addition
DGM98_03870	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DGM98_03875	COG1012	belongs to the aldehyde dehydrogenase family
DGM98_03880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DGM98_03895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DGM98_03910	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DGM98_03915	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DGM98_03935	COG2205	protein histidine kinase activity
DGM98_03965	COG3791	Glutathione-dependent formaldehyde-activating
DGM98_03980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DGM98_03990	COG0697	spore germination
DGM98_04000	COG0488	(ABC) transporter
DGM98_04010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DGM98_04015	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DGM98_04025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DGM98_04025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DGM98_04045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DGM98_04050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DGM98_04055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DGM98_04085	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DGM98_04090	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DGM98_04095	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DGM98_04100	COG2205	protein histidine kinase activity
DGM98_04105	COG0745	RESPONSE REGULATOR receiver
DGM98_04120	COG0277	FAD linked oxidase domain protein
DGM98_04125	COG1988	membrane-bound metal-dependent
DGM98_04130	COG0792	nuclease activity
DGM98_04165	COG0275	rRNA processing
DGM98_04170	COG3116	cell division
DGM98_04185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DGM98_04190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DGM98_04195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DGM98_04205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DGM98_04210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DGM98_04215	COG1181	Belongs to the D-alanine--D-alanine ligase family
DGM98_04220	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DGM98_04235	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DGM98_04245	COG0739	heme binding
DGM98_04250	COG0653	protein targeting
DGM98_04255	COG0494	nUDIX hydrolase
DGM98_04265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DGM98_04280	COG0604	alcohol dehydrogenase
DGM98_04280	COG3321	synthase
DGM98_04280	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_04300	COG0366	Alpha amylase catalytic
DGM98_04335	COG2226	methyltransferase
DGM98_04340	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DGM98_04350	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DGM98_04390	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DGM98_04400	COG4106	trans-aconitate 2-methyltransferase activity
DGM98_04405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DGM98_04415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGM98_04420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DGM98_04430	COG0667	Aldo Keto reductase
DGM98_04440	COG4771	TonB-dependent receptor
DGM98_04460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DGM98_04465	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DGM98_04475	COG2175	clavaminate synthase activity
DGM98_04485	COG4181	ATPase activity
DGM98_04500	COG0642	Histidine kinase
DGM98_04510	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DGM98_04530	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DGM98_04535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DGM98_04550	COG3829	transcription factor binding
DGM98_04560	COG1116	anion transmembrane transporter activity
DGM98_04565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DGM98_04575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DGM98_04580	COG0431	NADPH-dependent FMN reductase
DGM98_04600	COG0747	negative chemotaxis
DGM98_04610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DGM98_04620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DGM98_04625	COG2967	ApaG domain
DGM98_04630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DGM98_04635	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DGM98_04640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGM98_04645	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DGM98_04660	COG0123	including yeast histone deacetylase and acetoin utilization protein
DGM98_04665	COG2096	Adenosyltransferase
DGM98_04680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGM98_04685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGM98_04715	COG3384	dioxygenase
DGM98_04720	COG0583	DNA-binding transcription factor activity
DGM98_04735	COG1024	Enoyl-CoA hydratase
DGM98_04765	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DGM98_04790	COG0697	spore germination
DGM98_04800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGM98_04830	COG2197	response regulator
DGM98_04840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DGM98_04850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DGM98_04855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGM98_04865	COG0583	DNA-binding transcription factor activity
DGM98_04870	COG3634	alkyl hydroperoxide reductase activity
DGM98_04880	COG2890	protein-(glutamine-N5) methyltransferase activity
DGM98_04905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DGM98_04905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DGM98_04935	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DGM98_04980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DGM98_04990	COG1404	Belongs to the peptidase S8 family
DGM98_04995	COG1404	Belongs to the peptidase S8 family
DGM98_05000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DGM98_05025	COG1295	ribonuclease BN
DGM98_05030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGM98_05035	COG1254	Belongs to the acylphosphatase family
DGM98_05050	COG0521	Mo-molybdopterin cofactor biosynthetic process
DGM98_05060	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DGM98_05065	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DGM98_05075	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DGM98_05080	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DGM98_05090	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DGM98_05095	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DGM98_05100	COG0193	aminoacyl-tRNA hydrolase activity
DGM98_05105	COG0012	GTP binding
DGM98_05125	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DGM98_05140	COG0250	Participates in transcription elongation, termination and antitermination
DGM98_05145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DGM98_05150	COG0081	regulation of translation
DGM98_05155	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DGM98_05160	COG0222	ribosome binding
DGM98_05165	COG0085	RNA polymerase activity
DGM98_05170	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DGM98_05175	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DGM98_05180	COG0049	tRNA binding
DGM98_05185	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DGM98_05190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DGM98_05195	COG0051	transcription antitermination factor activity, RNA binding
DGM98_05200	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DGM98_05205	COG0088	Forms part of the polypeptide exit tunnel
DGM98_05210	COG0089	rRNA binding
DGM98_05215	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DGM98_05220	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DGM98_05230	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DGM98_05235	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DGM98_05240	COG0255	Belongs to the universal ribosomal protein uL29 family
DGM98_05245	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DGM98_05255	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DGM98_05260	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DGM98_05265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DGM98_05270	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DGM98_05275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DGM98_05280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DGM98_05290	COG1841	ribosomal large subunit assembly
DGM98_05295	COG0200	Binds to the 23S rRNA
DGM98_05300	COG0201	protein transport
DGM98_05325	COG0203	ribosomal protein L17
DGM98_05330	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DGM98_05350	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DGM98_05365	COG0154	amidase activity
DGM98_05375	COG1217	gtp-binding protein TYPA
DGM98_05380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DGM98_05385	COG0039	L-malate dehydrogenase activity
DGM98_05390	COG0625	glutathione transferase activity
DGM98_05405	COG0446	pyridine nucleotide-disulphide oxidoreductase
DGM98_05405	COG1902	pentaerythritol trinitrate reductase activity
DGM98_05410	COG0604	alcohol dehydrogenase
DGM98_05440	COG0156	8-amino-7-oxononanoate synthase activity
DGM98_05445	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DGM98_05450	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DGM98_05455	COG4208	sulfate ABC transporter
DGM98_05460	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DGM98_05490	COG0406	alpha-ribazole phosphatase activity
DGM98_05495	COG0285	dihydrofolate synthase activity
DGM98_05515	COG2833	Protein of unknown function (DUF455)
DGM98_05525	COG3291	Pkd domain containing protein
DGM98_05535	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGM98_05540	COG0671	phosphoesterase, PA-phosphatase related
DGM98_05545	COG0438	transferase activity, transferring glycosyl groups
DGM98_05555	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DGM98_05570	COG4783	chaperone-mediated protein folding
DGM98_05585	COG0473	3-isopropylmalate dehydrogenase activity
DGM98_05795	COG3179	chitinase
DGM98_05840	COG4695	Portal protein
DGM98_05880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DGM98_05905	COG3852	Histidine kinase
DGM98_05915	COG0544	peptidyl-prolyl cis-trans isomerase activity
DGM98_05925	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DGM98_05955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGM98_05970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGM98_05980	COG0328	RNA-DNA hybrid ribonuclease activity
DGM98_05985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DGM98_05990	COG0631	protein serine/threonine phosphatase activity
DGM98_06005	COG0859	PFAM glycosyl transferase family 9
DGM98_06010	COG3642	lipopolysaccharide core region biosynthetic process
DGM98_06015	COG1234	tRNA 3'-trailer cleavage
DGM98_06020	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DGM98_06030	COG0315	cyclic pyranopterin monophosphate synthase activity
DGM98_06035	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DGM98_06040	COG0314	molybdopterin synthase activity
DGM98_06060	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DGM98_06065	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DGM98_06070	COG0537	adenosine 5'-monophosphoramidase activity
DGM98_06090	COG0714	Associated with various cellular activities
DGM98_06115	COG0424	maF-like protein
DGM98_06120	COG1399	metal-binding, possibly nucleic acid-binding protein
DGM98_06130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGM98_06140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DGM98_06160	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DGM98_06165	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DGM98_06190	COG3829	transcription factor binding
DGM98_06235	COG2373	Large extracellular alpha-helical protein
DGM98_06255	COG4953	penicillin-binding protein 1C
DGM98_06265	COG0678	peroxiredoxin activity
DGM98_06285	COG0330	HflC and HflK could
DGM98_06290	COG0330	HflC and HflK could
DGM98_06305	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DGM98_06310	COG0308	aminopeptidase N
DGM98_06315	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_06320	COG1309	transcriptional regulator
DGM98_06415	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DGM98_06425	COG3387	PFAM Glycoside hydrolase 15-related
DGM98_06430	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_06440	COG3537	Alpha-1,2-mannosidase
DGM98_06445	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_06460	COG0492	ferredoxin-NADP+ reductase activity
DGM98_06490	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DGM98_06495	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DGM98_06500	COG2080	2 iron, 2 sulfur cluster binding
DGM98_06535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DGM98_06550	COG0587	DNA-directed DNA polymerase activity
DGM98_06565	COG1297	OPT oligopeptide transporter protein
DGM98_06585	COG0823	Involved in the tonB-independent uptake of proteins
DGM98_06585	COG1506	peptidase
DGM98_06600	COG1917	Cupin 2, conserved barrel domain protein
DGM98_06600	COG2207	Transcriptional regulator
DGM98_06625	COG0753	catalase activity
DGM98_06630	COG0656	L-ascorbic acid biosynthetic process
DGM98_06640	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DGM98_06640	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DGM98_06645	COG2814	Major facilitator Superfamily
DGM98_06660	COG2194	sulfuric ester hydrolase activity
DGM98_06675	COG0745	RESPONSE REGULATOR receiver
DGM98_06680	COG0642	Histidine kinase
DGM98_06690	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DGM98_06695	COG2894	cell division
DGM98_06700	COG0850	regulation of cytokinetic process
DGM98_06715	COG4585	Histidine kinase
DGM98_06720	COG2197	response regulator
DGM98_06735	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DGM98_06760	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DGM98_06770	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DGM98_06790	COG1946	Acyl-CoA thioesterase
DGM98_06805	COG0824	Thioesterase
DGM98_06810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DGM98_06815	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DGM98_06820	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DGM98_06825	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DGM98_06830	COG0268	Binds directly to 16S ribosomal RNA
DGM98_06840	COG0196	riboflavin kinase activity
DGM98_06845	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DGM98_06850	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DGM98_06855	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DGM98_06870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DGM98_06875	COG1845	cytochrome c oxidase, subunit III
DGM98_06880	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DGM98_06895	COG3152	Membrane
DGM98_06905	COG2207	Transcriptional regulator
DGM98_06910	COG0326	Molecular chaperone. Has ATPase activity
DGM98_06920	COG1366	Belongs to the anti-sigma-factor antagonist family
DGM98_06925	COG1366	Belongs to the anti-sigma-factor antagonist family
DGM98_06930	COG2172	sigma factor antagonist activity
DGM98_06955	COG4771	TonB-dependent receptor
DGM98_06965	COG5507	3-demethylubiquinone-9 3-methyltransferase
DGM98_06970	COG2205	protein histidine kinase activity
DGM98_06980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DGM98_06985	COG2205	protein histidine kinase activity
DGM98_06985	COG3437	response regulator, receiver
DGM98_06985	COG3850	Histidine kinase
DGM98_06985	COG4999	Histidine kinase
DGM98_06990	COG0784	Response regulator, receiver
DGM98_06990	COG4191	Histidine kinase
DGM98_07015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DGM98_07020	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DGM98_07030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DGM98_07035	COG0228	four-way junction DNA binding
DGM98_07040	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DGM98_07045	COG0336	Belongs to the RNA methyltransferase TrmD family
DGM98_07050	COG0335	large ribosomal subunit rRNA binding
DGM98_07055	COG0534	Mate efflux family protein
DGM98_07080	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DGM98_07090	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DGM98_07125	COG3250	beta-galactosidase activity
DGM98_07130	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DGM98_07150	COG1960	acyl-CoA dehydrogenase activity
DGM98_07155	COG1024	Enoyl-CoA hydratase
DGM98_07190	COG1024	Enoyl-CoA hydratase
DGM98_07190	COG1250	3-hydroxyacyl-CoA dehydrogenase
DGM98_07205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DGM98_07210	COG0481	GTPase activity
DGM98_07225	COG0571	ribonuclease III activity
DGM98_07230	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DGM98_07235	COG1381	Involved in DNA repair and RecF pathway recombination
DGM98_07245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DGM98_07250	COG2954	triphosphatase activity
DGM98_07255	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DGM98_07260	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
DGM98_07265	COG3046	protein related to deoxyribodipyrimidine photolyase
DGM98_07270	COG1472	Belongs to the glycosyl hydrolase 3 family
DGM98_07275	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DGM98_07280	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DGM98_07285	COG1278	Cold shock
DGM98_07290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGM98_07300	COG1201	RNA secondary structure unwinding
DGM98_07305	COG1793	dna ligase
DGM98_07315	COG1793	dna ligase
DGM98_07315	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DGM98_07350	COG0183	Belongs to the thiolase family
DGM98_07375	COG1451	nucleotide metabolic process
DGM98_07380	COG5487	UPF0391 membrane protein
DGM98_07390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DGM98_07405	COG1077	Cell shape determining protein MreB Mrl
DGM98_07410	COG1047	Peptidyl-prolyl cis-trans
DGM98_07420	COG2824	Alkylphosphonate utilization operon protein PhnA
DGM98_07430	COG1902	pentaerythritol trinitrate reductase activity
DGM98_07435	COG2814	Major facilitator Superfamily
DGM98_07470	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DGM98_07470	COG0392	lysyltransferase activity
DGM98_07480	COG0251	oxidation-reduction process
DGM98_07485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DGM98_07500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DGM98_07525	COG1595	DNA-templated transcription, initiation
DGM98_07545	COG2878	Part of a membrane complex involved in electron transport
DGM98_07555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGM98_07555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGM98_07570	COG1131	(ABC) transporter
DGM98_07575	COG0346	lactoylglutathione lyase activity
DGM98_07580	COG0833	amino acid
DGM98_07585	COG2040	homocysteine
DGM98_07595	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DGM98_07615	COG1695	Transcriptional regulator
DGM98_07635	COG1981	membrane
DGM98_07650	COG0825	malonyl-CoA metabolic process
DGM98_07665	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGM98_07670	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGM98_07675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DGM98_07680	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGM98_07695	COG0750	zinc metalloprotease
DGM98_07700	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DGM98_07705	COG0575	Belongs to the CDS family
DGM98_07710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DGM98_07715	COG0233	cytoplasmic translational termination
DGM98_07720	COG0528	UMP kinase activity
DGM98_07730	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DGM98_07735	COG0052	Belongs to the universal ribosomal protein uS2 family
DGM98_07775	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DGM98_07785	COG1393	Belongs to the ArsC family
DGM98_07790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DGM98_07795	COG0367	asparagine synthase
DGM98_07805	COG4774	siderophore transport
DGM98_07890	COG4397	Mu-like prophage major head subunit gpT
DGM98_07910	COG2369	cell adhesion
DGM98_07915	COG4383	Mu-like prophage protein gp29
DGM98_07920	COG4373	Mu-like prophage FluMu protein gp28
DGM98_07940	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DGM98_07965	COG5566	PFAM Mor transcription activator
DGM98_08030	COG2842	Transposition protein
DGM98_08035	COG2801	Transposase and inactivated derivatives
DGM98_08075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DGM98_08105	COG1566	PFAM secretion protein HlyD family protein
DGM98_08110	COG2814	Major facilitator Superfamily
DGM98_08160	COG0339	signal peptide processing
DGM98_08170	COG0386	Belongs to the glutathione peroxidase family
DGM98_08225	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DGM98_08230	COG0084	hydrolase, TatD family'
DGM98_08245	COG1960	acyl-CoA dehydrogenase activity
DGM98_08265	COG0367	asparagine synthase
DGM98_08275	COG0305	Participates in initiation and elongation during chromosome replication
DGM98_08280	COG0415	Belongs to the DNA photolyase family
DGM98_08290	COG0583	DNA-binding transcription factor activity
DGM98_08335	COG3706	GGDEF domain
DGM98_08535	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DGM98_08550	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGM98_08560	COG0497	DNA recombination
DGM98_08565	COG1420	regulation of RNA biosynthetic process
DGM98_08570	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DGM98_08575	COG0443	Heat shock 70 kDa protein
DGM98_08580	COG0484	heat shock protein binding
DGM98_08590	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DGM98_08620	COG0583	DNA-binding transcription factor activity
DGM98_08630	COG1132	(ABC) transporter
DGM98_08655	COG0567	Dehydrogenase, E1 component
DGM98_08665	COG2850	peptidyl-arginine hydroxylation
DGM98_08690	COG1253	flavin adenine dinucleotide binding
DGM98_08725	COG1131	(ABC) transporter
DGM98_08730	COG1725	Transcriptional regulator
DGM98_08740	COG0386	Belongs to the glutathione peroxidase family
DGM98_08755	COG2900	Belongs to the SlyX family
DGM98_08780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGM98_08790	COG0646	methionine synthase
DGM98_08790	COG1410	methionine synthase
DGM98_08795	COG0646	methionine synthase
DGM98_08795	COG1410	methionine synthase
DGM98_08800	COG2226	methyltransferase
DGM98_08805	COG1960	acyl-CoA dehydrogenase activity
DGM98_08815	COG1960	acyl-CoA dehydrogenase activity
DGM98_08845	COG0557	exoribonuclease II activity
DGM98_08855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DGM98_08865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DGM98_08875	COG0704	Plays a role in the regulation of phosphate uptake
DGM98_08880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DGM98_08885	COG0581	inorganic phosphate transmembrane transporter activity
DGM98_08890	COG0573	inorganic phosphate transmembrane transporter activity
DGM98_08895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DGM98_08920	COG0659	secondary active sulfate transmembrane transporter activity
DGM98_08925	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DGM98_08935	COG1024	Enoyl-CoA hydratase
DGM98_08945	COG0494	nUDIX hydrolase
DGM98_08990	COG0116	Belongs to the methyltransferase superfamily
DGM98_08990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DGM98_08995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DGM98_09020	COG2925	Exonuclease
DGM98_09025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGM98_09030	COG3844	kynureninase activity
DGM98_09040	COG0662	Cupin 2, conserved barrel domain protein
DGM98_09045	COG0288	reversible hydration of carbon dioxide
DGM98_09125	COG0017	Asparaginyl-tRNA synthetase
DGM98_09135	COG0316	Belongs to the HesB IscA family
DGM98_09140	COG0360	Binds together with S18 to 16S ribosomal RNA
DGM98_09145	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DGM98_09150	COG0359	binds to the 23S rRNA
DGM98_09165	COG3115	cell septum assembly
DGM98_09175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGM98_09180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DGM98_09185	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DGM98_09200	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DGM98_09210	COG4993	Dehydrogenase
DGM98_09220	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DGM98_09230	COG2986	histidine ammonia-lyase
DGM98_09235	COG1228	amidohydrolase
DGM98_09275	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DGM98_09280	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DGM98_09285	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DGM98_09290	COG0077	Prephenate dehydratase
DGM98_09290	COG1605	Chorismate mutase
DGM98_09295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DGM98_09315	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DGM98_09320	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DGM98_09325	COG0583	DNA-binding transcription factor activity
DGM98_09340	COG0840	transmembrane signaling receptor activity
DGM98_09375	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DGM98_09380	COG0784	Response regulator, receiver
DGM98_09380	COG4191	Histidine kinase
DGM98_09395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGM98_09405	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DGM98_09415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DGM98_09430	COG1595	DNA-templated transcription, initiation
DGM98_09485	COG2244	polysaccharide biosynthetic process
DGM98_09515	COG2264	protein methyltransferase activity
DGM98_09540	COG1136	(ABC) transporter
DGM98_09550	COG0477	Major facilitator Superfamily
DGM98_09555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DGM98_09570	COG1253	flavin adenine dinucleotide binding
DGM98_09585	COG0306	phosphate transporter
DGM98_09615	COG0504	CTP synthase activity
DGM98_09630	COG0148	phosphopyruvate hydratase activity
DGM98_09635	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DGM98_09640	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DGM98_09645	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DGM98_09650	COG0585	pseudouridine synthase activity
DGM98_09655	COG2840	Smr protein MutS2
DGM98_09660	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DGM98_09665	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DGM98_09670	COG1238	metal cluster binding
DGM98_09685	COG1534	Rna-binding protein
DGM98_09690	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DGM98_09700	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DGM98_09705	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DGM98_09715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DGM98_09720	COG1546	Belongs to the CinA family
DGM98_09730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DGM98_09735	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DGM98_09745	COG2137	regulation of response to DNA damage stimulus
DGM98_09750	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DGM98_09755	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DGM98_09780	COG1741	Belongs to the pirin family
DGM98_09785	COG0583	DNA-binding transcription factor activity
DGM98_09810	COG0351	phosphomethylpyrimidine kinase
DGM98_09825	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DGM98_09830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DGM98_09845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DGM98_09855	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DGM98_09860	COG3734	2-keto-3-deoxy-galactonokinase
DGM98_09870	COG4948	Mandelate Racemase Muconate Lactonizing
DGM98_09875	COG0800	Aldolase
DGM98_09915	COG1501	Belongs to the glycosyl hydrolase 31 family
DGM98_09925	COG1070	Carbohydrate kinase
DGM98_09930	COG2115	Belongs to the xylose isomerase family
DGM98_09935	COG0477	Major facilitator Superfamily
DGM98_09950	COG0860	N-Acetylmuramoyl-L-alanine amidase
DGM98_09955	COG1469	GTP cyclohydrolase I activity
DGM98_09975	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DGM98_09980	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DGM98_09985	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DGM98_10010	COG1472	Belongs to the glycosyl hydrolase 3 family
DGM98_10025	COG2203	Gaf domain
DGM98_10025	COG3706	GGDEF domain
DGM98_10025	COG4251	negative regulation of phosphorylation
DGM98_10025	COG5001	Diguanylate cyclase
DGM98_10030	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGM98_10035	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DGM98_10045	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DGM98_10050	COG0671	phosphoesterase, PA-phosphatase related
DGM98_10065	COG1794	racemase activity, acting on amino acids and derivatives
DGM98_10075	COG0697	spore germination
DGM98_10080	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DGM98_10085	COG0167	dihydroorotate dehydrogenase activity
DGM98_10105	COG1012	belongs to the aldehyde dehydrogenase family
DGM98_10145	COG1215	transferase activity, transferring glycosyl groups
DGM98_10150	COG1649	PFAM Uncharacterised BCR, COG1649
DGM98_10150	COG0726	polysaccharide deacetylase
DGM98_10205	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DGM98_10215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGM98_10220	COG0124	histidyl-tRNA synthetase
DGM98_10230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DGM98_10235	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DGM98_10240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGM98_10245	COG0131	Imidazoleglycerol-phosphate dehydratase
DGM98_10245	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DGM98_10250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DGM98_10255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DGM98_10260	COG0107	imidazoleglycerol-phosphate synthase activity
DGM98_10265	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DGM98_10265	COG0140	phosphoribosyl-ATP diphosphatase activity
DGM98_10280	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
DGM98_10285	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DGM98_10290	COG0235	Class ii aldolase
DGM98_10295	COG0531	amino acid
DGM98_10300	COG0531	amino acid
DGM98_10310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DGM98_10315	COG0277	FAD linked oxidase domain protein
DGM98_10335	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DGM98_10380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DGM98_10390	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DGM98_10395	COG0505	Belongs to the CarA family
DGM98_10405	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DGM98_10410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGM98_10420	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DGM98_10430	COG3279	Response regulator of the LytR AlgR family
DGM98_10440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DGM98_10450	COG2205	protein histidine kinase activity
DGM98_10450	COG0784	Response regulator, receiver
DGM98_10450	COG2198	Histidine kinase
DGM98_10455	COG2205	protein histidine kinase activity
DGM98_10455	COG2198	Histidine kinase
DGM98_10455	COG0784	Response regulator, receiver
DGM98_10460	COG1024	Enoyl-CoA hydratase
DGM98_10465	COG0318	PFAM AMP-dependent synthetase and ligase
DGM98_10500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGM98_10510	COG2201	protein-glutamate methylesterase activity
DGM98_10515	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DGM98_10525	COG0840	transmembrane signaling receptor activity
DGM98_10540	COG0835	chemotaxis
DGM98_10570	COG0840	transmembrane signaling receptor activity
DGM98_10575	COG0840	transmembrane signaling receptor activity
DGM98_10585	COG0840	transmembrane signaling receptor activity
DGM98_10595	COG0840	transmembrane signaling receptor activity
DGM98_10605	COG0840	transmembrane signaling receptor activity
DGM98_10610	COG0840	transmembrane signaling receptor activity
DGM98_10615	COG0840	transmembrane signaling receptor activity
DGM98_10630	COG0840	transmembrane signaling receptor activity
DGM98_10655	COG0745	RESPONSE REGULATOR receiver
DGM98_10665	COG0835	chemotaxis
DGM98_10675	COG1360	Flagellar Motor Protein
DGM98_10680	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DGM98_10700	COG1192	Involved in chromosome partitioning
DGM98_10765	COG2198	Histidine kinase
DGM98_10765	COG0784	Response regulator, receiver
DGM98_10765	COG0643	Histidine kinase
DGM98_10830	COG1684	flagellar biosynthetic protein fliR
DGM98_10850	COG3190	flagellar
DGM98_10900	COG1677	Flagellar hook-basal body complex protein FliE
DGM98_10935	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_10940	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_10945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGM98_10965	COG2201	protein-glutamate methylesterase activity
DGM98_10995	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DGM98_11005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DGM98_11015	COG1705	Flagellar rod assembly protein muramidase FlgJ
DGM98_11015	COG3951	Flagellar rod assembly protein muramidase FlgJ
DGM98_11020	COG1706	bacterial-type flagellum-dependent cell motility
DGM98_11025	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DGM98_11035	COG4787	bacterial-type flagellum-dependent cell motility
DGM98_11045	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DGM98_11050	COG1558	bacterial-type flagellum-dependent cell motility
DGM98_11060	COG0784	Response regulator, receiver
DGM98_11060	COG0835	chemotaxis
DGM98_11080	COG5002	protein histidine kinase activity
DGM98_11110	COG2915	High frequency lysogenization protein hflD homolog
DGM98_11115	COG0482	sulfurtransferase activity
DGM98_11130	COG0542	response to heat
DGM98_11140	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DGM98_11150	COG0492	ferredoxin-NADP+ reductase activity
DGM98_11155	COG1674	ftsk spoiiie
DGM98_11165	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DGM98_11175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DGM98_11180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DGM98_11190	COG0183	Belongs to the thiolase family
DGM98_11195	COG1250	3-hydroxyacyl-CoA dehydrogenase
DGM98_11195	COG1024	Enoyl-CoA hydratase
DGM98_11210	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DGM98_11220	COG1426	Protein conserved in bacteria
DGM98_11230	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGM98_11235	COG1160	GTP binding
DGM98_11240	COG0303	'Molybdopterin
DGM98_11245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DGM98_11285	COG0708	Exodeoxyribonuclease III
DGM98_11295	COG0303	'Molybdopterin
DGM98_11300	COG0746	molybdenum cofactor guanylyltransferase activity
DGM98_11330	COG1914	H( )-stimulated, divalent metal cation uptake system
DGM98_11345	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DGM98_11350	COG0668	transmembrane transport
DGM98_11360	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DGM98_11375	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_11380	COG1183	phosphatidylcholine synthase activity
DGM98_11390	COG3243	poly(R)-hydroxyalkanoic acid synthase
DGM98_11405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGM98_11405	COG0723	plastoquinol--plastocyanin reductase activity
DGM98_11415	COG2183	response to ionizing radiation
DGM98_11420	COG0784	Response regulator, receiver
DGM98_11420	COG2205	protein histidine kinase activity
DGM98_11480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGM98_11490	COG0800	Aldolase
DGM98_11495	COG0129	dihydroxy-acid dehydratase activity
DGM98_11500	COG0363	glucosamine-6-phosphate deaminase activity
DGM98_11505	COG0837	glucose binding
DGM98_11510	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DGM98_11520	COG0354	folic acid binding
DGM98_11535	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DGM98_11550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DGM98_11555	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DGM98_11565	COG4591	ABC-type transport system involved in lipoprotein release permease component
DGM98_11570	COG1136	(ABC) transporter
DGM98_11585	COG0811	peptide transport
DGM98_11590	COG0848	biopolymer transport protein
DGM98_11595	COG1132	(ABC) transporter
DGM98_11600	COG1663	tetraacyldisaccharide 4'-kinase activity
DGM98_11605	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DGM98_11610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DGM98_11620	COG0322	excinuclease ABC activity
DGM98_11625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DGM98_11650	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DGM98_11670	COG1054	Belongs to the UPF0176 family
DGM98_11680	COG1530	ribonuclease E activity
DGM98_11690	COG3064	Membrane
DGM98_11695	COG0428	transporter
DGM98_11705	COG2154	pterin-4-alpha-carbinolamine dehydratase
DGM98_11710	COG0316	Belongs to the HesB IscA family
DGM98_11710	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DGM98_11760	COG1073	alpha beta
DGM98_11760	COG2226	methyltransferase
DGM98_11765	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DGM98_11770	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_11780	COG5599	Phosphatase
DGM98_11825	COG2951	lytic endotransglycosylase activity
DGM98_11855	COG3220	belongs to the UPF0276 family
DGM98_11880	COG3920	Histidine kinase
DGM98_11890	COG1238	metal cluster binding
DGM98_11920	COG3279	Response regulator of the LytR AlgR family
DGM98_11965	COG4566	intracellular signal transduction
DGM98_11975	COG5001	Diguanylate cyclase
DGM98_11995	COG3685	Protein conserved in bacteria
DGM98_12015	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DGM98_12015	COG1648	precorrin-2 dehydrogenase activity
DGM98_12030	COG2814	Major facilitator Superfamily
DGM98_12045	COG1335	isochorismatase
DGM98_12060	COG2197	response regulator
DGM98_12075	COG0583	DNA-binding transcription factor activity
DGM98_12080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DGM98_12085	COG3002	Belongs to the UPF0753 family
DGM98_12090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DGM98_12090	COG0519	Catalyzes the synthesis of GMP from XMP
DGM98_12100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DGM98_12115	COG0475	glutathione-regulated potassium exporter activity
DGM98_12115	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DGM98_12125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DGM98_12135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DGM98_12140	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DGM98_12150	COG0776	regulation of translation
DGM98_12155	COG0539	negative regulation of cytoplasmic translation
DGM98_12160	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DGM98_12180	COG2957	Belongs to the agmatine deiminase family
DGM98_12185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGM98_12210	COG0395	ABC-type sugar transport system, permease component
DGM98_12215	COG1175	transmembrane transport
DGM98_12245	COG2350	Protein conserved in bacteria
DGM98_12250	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DGM98_12255	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DGM98_12260	COG1187	pseudouridine synthase activity
DGM98_12285	COG0436	Aminotransferase
DGM98_12290	COG4133	protoheme IX ABC transporter activity
DGM98_12310	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DGM98_12315	COG1138	Cytochrome C-type biogenesis protein
DGM98_12335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGM98_12340	COG1278	Cold shock
DGM98_12345	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DGM98_12350	COG4988	ABC transporter
DGM98_12360	COG1294	oxidase, subunit
DGM98_12390	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DGM98_12395	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DGM98_12405	COG0165	Argininosuccinate lyase
DGM98_12410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DGM98_12420	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DGM98_12425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DGM98_12435	COG0137	argininosuccinate synthase activity
DGM98_12440	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DGM98_12450	COG0215	cysteine-tRNA ligase activity
DGM98_12455	COG2166	iron-sulfur cluster assembly
DGM98_12470	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DGM98_12475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DGM98_12495	COG4302	ethanolamine ammonia-lyase activity
DGM98_12545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DGM98_12550	COG0402	S-adenosylhomocysteine deaminase activity
DGM98_12560	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DGM98_12570	COG3300	MHYT domain
DGM98_12570	COG5001	Diguanylate cyclase
DGM98_12585	COG0483	inositol monophosphate 1-phosphatase activity
DGM98_12590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DGM98_12610	COG0488	(ABC) transporter
DGM98_12615	COG0513	Belongs to the DEAD box helicase family
DGM98_12620	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DGM98_12625	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DGM98_12635	COG0625	glutathione transferase activity
DGM98_12645	COG4681	YaeQ
DGM98_12650	COG2081	HI0933 family
DGM98_12660	COG0501	Belongs to the peptidase M48B family
DGM98_12665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGM98_12670	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_12695	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DGM98_12700	COG0860	N-Acetylmuramoyl-L-alanine amidase
DGM98_12705	COG0802	atpase or kinase
DGM98_12710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DGM98_12710	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DGM98_12715	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DGM98_12720	COG1570	exodeoxyribonuclease VII activity
DGM98_12735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DGM98_12775	COG0582	viral genome integration into host DNA
DGM98_12975	COG0305	Participates in initiation and elongation during chromosome replication
DGM98_13060	COG3723	Recombinational DNA repair protein, rece pathway
DGM98_13095	COG0835	chemotaxis
DGM98_13100	COG0840	transmembrane signaling receptor activity
DGM98_13105	COG2094	Belongs to the DNA glycosylase MPG family
DGM98_13110	COG1201	RNA secondary structure unwinding
DGM98_13130	COG2969	positive regulation of protein catabolic process
DGM98_13135	COG0625	glutathione transferase activity
DGM98_13140	COG2857	Cytochrome c1
DGM98_13145	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DGM98_13150	COG0723	plastoquinol--plastocyanin reductase activity
DGM98_13160	COG0741	lytic transglycosylase activity
DGM98_13175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DGM98_13180	COG1702	phosphate starvation-inducible protein PhoH
DGM98_13190	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DGM98_13200	COG4535	Mg2 and Co2 transporter CorC
DGM98_13215	COG1012	belongs to the aldehyde dehydrogenase family
DGM98_13220	COG1177	transmembrane transport
DGM98_13225	COG1176	ABC-type spermidine putrescine transport system, permease component I
DGM98_13235	COG3842	ATPase activity
DGM98_13255	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DGM98_13275	COG0174	glutamine synthetase
DGM98_13280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGM98_13290	COG2703	oxygen carrier activity
DGM98_13295	COG0477	Major facilitator Superfamily
DGM98_13310	COG0243	molybdopterin cofactor binding
DGM98_13315	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DGM98_13320	COG2223	nitrite transmembrane transporter activity
DGM98_13330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DGM98_13340	COG2733	membrane
DGM98_13345	COG0784	Response regulator, receiver
DGM98_13345	COG2205	protein histidine kinase activity
DGM98_13345	COG5002	protein histidine kinase activity
DGM98_13365	COG0477	Major facilitator Superfamily
DGM98_13370	COG2902	Dehydrogenase
DGM98_13380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGM98_13385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGM98_13390	COG1609	Transcriptional regulator
DGM98_13395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DGM98_13395	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGM98_13400	COG1105	Belongs to the carbohydrate kinase PfkB family
DGM98_13405	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DGM98_13405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DGM98_13440	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DGM98_13450	COG1862	Preprotein translocase
DGM98_13455	COG0343	queuine tRNA-ribosyltransferase activity
DGM98_13460	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DGM98_13495	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DGM98_13500	COG3291	Pkd domain containing protein
DGM98_13505	COG0405	Gamma-glutamyltransferase
DGM98_13510	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DGM98_13520	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DGM98_13525	COG0742	ribosomal rna small subunit methyltransferase
DGM98_13530	COG0326	Molecular chaperone. Has ATPase activity
DGM98_13635	COG0531	amino acid
DGM98_13650	COG0006	proline dipeptidase activity
DGM98_13660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DGM98_13675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGM98_13680	COG3938	Belongs to the proline racemase family
DGM98_13690	COG0552	protein localization to endoplasmic reticulum
DGM98_13700	COG1194	a g-specific adenine glycosylase
DGM98_13705	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
DGM98_13710	COG4191	Histidine kinase
DGM98_13710	COG0784	Response regulator, receiver
DGM98_13725	COG0322	excinuclease ABC activity
DGM98_13740	COG3040	lipid binding
DGM98_13750	COG1960	acyl-CoA dehydrogenase activity
DGM98_13760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DGM98_13780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGM98_13785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGM98_13790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGM98_13815	COG0438	transferase activity, transferring glycosyl groups
DGM98_13825	COG0438	transferase activity, transferring glycosyl groups
DGM98_13830	COG0438	transferase activity, transferring glycosyl groups
DGM98_13880	COG0072	phenylalanine-tRNA ligase activity
DGM98_13880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGM98_13885	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DGM98_13900	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DGM98_13905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DGM98_13920	COG2190	(PTS) system
DGM98_13920	COG2211	Major facilitator Superfamily
DGM98_13930	COG1082	Xylose isomerase domain protein TIM barrel
DGM98_13945	COG0366	Alpha amylase catalytic
DGM98_13980	COG3702	type iv secretory pathway
DGM98_14000	COG2948	multi-organism process
DGM98_14020	COG3505	Type IV secretory pathway VirD4
DGM98_14030	COG0582	viral genome integration into host DNA
DGM98_14040	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
DGM98_14160	COG0556	nucleotide-excision repair
DGM98_14165	COG4969	Belongs to the N-Me-Phe pilin family
DGM98_14200	COG4969	Belongs to the N-Me-Phe pilin family
DGM98_14205	COG1611	Belongs to the LOG family
DGM98_14220	COG2095	MarC family integral membrane protein
DGM98_14230	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DGM98_14265	COG1185	polyribonucleotide nucleotidyltransferase activity
DGM98_14270	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DGM98_14275	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DGM98_14280	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DGM98_14285	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DGM98_14290	COG0195	Participates in both transcription termination and antitermination
DGM98_14295	COG0779	Required for maturation of 30S ribosomal subunits
DGM98_14305	COG1007	ATP synthesis coupled electron transport
DGM98_14330	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGM98_14335	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DGM98_14345	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DGM98_14350	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DGM98_14355	COG0649	NAD binding
DGM98_14360	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGM98_14365	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGM98_14370	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGM98_14385	COG0149	triose-phosphate isomerase activity
DGM98_14390	COG0300	oxidoreductase activity
DGM98_14420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DGM98_14425	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DGM98_14430	COG0159	tryptophan synthase activity
DGM98_14440	COG0133	tryptophan synthase activity
DGM98_14450	COG0135	phosphoribosylanthranilate isomerase activity
DGM98_14455	COG0101	tRNA pseudouridine synthase activity
DGM98_14470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DGM98_14475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DGM98_14480	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DGM98_14485	COG2890	protein-(glutamine-N5) methyltransferase activity
DGM98_14495	COG0688	phosphatidylethanolamine metabolic process
DGM98_14510	COG0433	COG0433 Predicted ATPase
DGM98_14515	COG0494	nUDIX hydrolase
DGM98_14530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGM98_14535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DGM98_14560	COG0717	Belongs to the dCTP deaminase family
DGM98_14570	COG0489	protein tyrosine kinase activity
DGM98_14590	COG3590	peptidase
DGM98_14595	COG3590	peptidase
DGM98_14615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DGM98_14620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGM98_14625	COG2311	Membrane
DGM98_14630	COG1047	Peptidyl-prolyl cis-trans
DGM98_14635	COG0791	NLP P60 protein
DGM98_14640	COG0791	NLP P60 protein
DGM98_14650	COG4106	trans-aconitate 2-methyltransferase activity
DGM98_14655	COG1301	dicarboxylic acid transport
DGM98_14660	COG1785	Belongs to the alkaline phosphatase family
DGM98_14670	COG0037	tRNA processing
DGM98_14675	COG1722	exodeoxyribonuclease VII activity
DGM98_14680	COG0142	geranyltranstransferase activity
DGM98_14685	COG4104	PAAR repeat-containing protein
DGM98_14695	COG0312	modulator of DNA gyrase
DGM98_14700	COG3028	Belongs to the UPF0307 family
DGM98_14705	COG0312	modulator of DNA gyrase
DGM98_14715	COG3164	Protein of unknown function
DGM98_14725	COG0424	maF-like protein
DGM98_14730	COG2968	Membrane
DGM98_14745	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DGM98_14760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DGM98_14775	COG0495	leucyl-tRNA aminoacylation
DGM98_14785	COG3118	belongs to the thioredoxin family
DGM98_14820	COG2155	Conserved Protein
DGM98_14865	COG1132	(ABC) transporter
DGM98_14890	COG1538	Outer membrane efflux protein
DGM98_14895	COG0745	RESPONSE REGULATOR receiver
DGM98_14900	COG5002	protein histidine kinase activity
DGM98_14900	COG5000	phosphorelay sensor kinase activity
DGM98_14905	COG0475	glutathione-regulated potassium exporter activity
DGM98_14915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DGM98_14935	COG1187	pseudouridine synthase activity
DGM98_14940	COG5002	protein histidine kinase activity
DGM98_14940	COG5001	Diguanylate cyclase
DGM98_14950	COG1595	DNA-templated transcription, initiation
DGM98_15060	COG2951	lytic endotransglycosylase activity
DGM98_15115	COG0667	Aldo Keto reductase
DGM98_15120	COG2814	Major facilitator Superfamily
DGM98_15125	COG0583	DNA-binding transcription factor activity
DGM98_15135	COG2207	Transcriptional regulator
DGM98_15145	COG1309	transcriptional regulator
DGM98_15155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGM98_15170	COG0735	belongs to the Fur family
DGM98_15175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGM98_15200	COG4452	Inner membrane protein CreD
DGM98_15210	COG2205	protein histidine kinase activity
DGM98_15215	COG0745	RESPONSE REGULATOR receiver
DGM98_15220	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DGM98_15230	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DGM98_15240	COG0643	Histidine kinase
DGM98_15240	COG2198	Histidine kinase
DGM98_15245	COG0840	transmembrane signaling receptor activity
DGM98_15250	COG0835	chemotaxis
DGM98_15255	COG2200	EAL domain
DGM98_15255	COG2199	diguanylate cyclase activity
DGM98_15255	COG2202	Pas domain
DGM98_15260	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DGM98_15270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGM98_15275	COG3590	peptidase
DGM98_15285	COG0588	phosphoglycerate mutase activity
DGM98_15290	COG1515	deoxyribonuclease V activity
DGM98_15300	COG1741	Belongs to the pirin family
DGM98_15315	COG1741	Belongs to the pirin family
DGM98_15320	COG1966	Carbon starvation protein
DGM98_15325	COG2879	small protein
DGM98_15375	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DGM98_15380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DGM98_15385	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DGM98_15390	COG2080	2 iron, 2 sulfur cluster binding
DGM98_15395	COG0604	alcohol dehydrogenase
DGM98_15395	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_15395	COG3321	synthase
DGM98_15405	COG0629	single-stranded DNA binding
DGM98_15410	COG0142	geranyltranstransferase activity
DGM98_15425	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DGM98_15440	COG0527	aspartate kinase activity
DGM98_15445	COG0384	phenazine biosynthesis protein PhzF
DGM98_15450	COG0384	phenazine biosynthesis protein PhzF
DGM98_15460	COG1764	response to oxidative stress
DGM98_15465	COG0540	Belongs to the ATCase OTCase family
DGM98_15470	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DGM98_15475	COG1678	Uncharacterized ACR, COG1678
DGM98_15485	COG0519	Catalyzes the synthesis of GMP from XMP
DGM98_15515	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DGM98_15530	COG0739	heme binding
DGM98_15550	COG0693	protein deglycase activity
DGM98_15560	COG1959	2 iron, 2 sulfur cluster binding
DGM98_15565	COG0719	Fe-S assembly protein
DGM98_15570	COG0396	ATPase activity
DGM98_15575	COG0719	Fe-S assembly protein
DGM98_15580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DGM98_15590	COG2146	nitrite reductase [NAD(P)H] activity
DGM98_15600	COG3128	pkhd-type hydroxylase
DGM98_15625	COG1477	protein flavinylation
DGM98_15630	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGM98_15640	COG1555	photosystem II stabilization
DGM98_15655	COG3178	'Phosphotransferase
DGM98_15660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DGM98_15680	COG0628	permease
DGM98_15690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DGM98_15700	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DGM98_15720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DGM98_15725	COG0271	Belongs to the BolA IbaG family
DGM98_15735	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DGM98_15745	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DGM98_15750	COG1137	ATPase activity
DGM98_15765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGM98_15770	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DGM98_15775	COG1660	Displays ATPase and GTPase activities
DGM98_15785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGM98_15790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DGM98_15800	COG2239	Acts as a magnesium transporter
DGM98_15810	COG1294	oxidase, subunit
DGM98_15815	COG1271	oxidase subunit
DGM98_15825	COG1113	amino acid transport
DGM98_15840	COG3328	transposase activity
DGM98_15865	COG2197	response regulator
DGM98_15870	COG0531	amino acid
DGM98_15980	COG2814	Major facilitator Superfamily
DGM98_15990	COG0754	glutathionylspermidine amidase activity
DGM98_16015	COG1842	Phage shock protein A
DGM98_16025	COG0259	pyridoxamine-phosphate oxidase activity
DGM98_16030	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DGM98_16035	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DGM98_16045	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DGM98_16050	COG2814	Major facilitator Superfamily
DGM98_16070	COG0784	Response regulator, receiver
DGM98_16070	COG2198	Histidine kinase
DGM98_16070	COG2205	protein histidine kinase activity
DGM98_16075	COG2353	YceI-like domain
DGM98_16095	COG1760	l-serine dehydratase
DGM98_16110	COG0527	aspartate kinase activity
DGM98_16110	COG0460	homoserine dehydrogenase
DGM98_16115	COG0626	cystathionine gamma-synthase activity
DGM98_16120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGM98_16125	COG0739	heme binding
DGM98_16130	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DGM98_16135	COG1272	protein, Hemolysin III
DGM98_16140	COG2982	Protein involved in outer membrane biogenesis
DGM98_16145	COG0516	GMP reductase activity
DGM98_16145	COG0517	IMP dehydrogenase activity
DGM98_16150	COG0463	Glycosyl transferase, family 2
DGM98_16155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DGM98_16160	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DGM98_16170	COG4771	TonB-dependent receptor
DGM98_16180	COG1309	transcriptional regulator
DGM98_16190	COG1960	acyl-CoA dehydrogenase activity
DGM98_16220	COG0509	glycine decarboxylation via glycine cleavage system
DGM98_16225	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DGM98_16240	COG1742	UPF0060 membrane protein
DGM98_16245	COG3956	TIGRFAM MazG family protein
DGM98_16250	COG1218	3'(2'),5'-bisphosphate nucleotidase
DGM98_16255	COG0494	nUDIX hydrolase
DGM98_16265	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DGM98_16270	COG0837	glucose binding
DGM98_16285	COG1388	LysM domain
DGM98_16285	COG3858	chitin binding
DGM98_16300	COG1472	Belongs to the glycosyl hydrolase 3 family
DGM98_16315	COG0531	amino acid
DGM98_16325	COG1486	melibiose metabolic process
DGM98_16335	COG3537	Alpha-1,2-mannosidase
DGM98_16380	COG3142	Participates in the control of copper homeostasis
DGM98_16385	COG1446	asparaginase
DGM98_16410	COG0784	Response regulator, receiver
DGM98_16410	COG0643	Histidine kinase
DGM98_16410	COG2198	Histidine kinase
DGM98_16415	COG0840	transmembrane signaling receptor activity
DGM98_16420	COG0835	chemotaxis
DGM98_16435	COG0189	ligase activity
DGM98_16445	COG1397	ADP-ribosylglycohydrolase
DGM98_16455	COG1199	ATP-dependent helicase activity
DGM98_16465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DGM98_16470	COG1216	Glycosyl transferase, family 2
DGM98_16470	COG1442	glycosyl transferase family 8
DGM98_16490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DGM98_16500	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DGM98_16505	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DGM98_16510	COG0535	radical SAM domain protein
DGM98_16515	COG0535	radical SAM domain protein
DGM98_16530	COG0837	glucose binding
DGM98_16545	COG1643	Atp-dependent helicase
DGM98_16550	COG0783	Belongs to the Dps family
DGM98_16555	COG0514	ATP-dependent DNA helicase (RecQ)
DGM98_16595	COG0840	transmembrane signaling receptor activity
DGM98_16615	COG3920	Histidine kinase
DGM98_16620	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DGM98_16630	COG0602	queuosine metabolic process
DGM98_16640	COG2885	chlorophyll binding
DGM98_16645	COG0823	Involved in the tonB-independent uptake of proteins
DGM98_16655	COG0848	biopolymer transport protein
DGM98_16665	COG0824	Thioesterase
DGM98_16670	COG2255	four-way junction helicase activity
DGM98_16680	COG3158	transport of potassium into the cell
DGM98_16685	COG0632	four-way junction helicase activity
DGM98_16690	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DGM98_16695	COG0217	transcriptional regulatory protein
DGM98_16710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DGM98_16725	COG0477	Major facilitator Superfamily
DGM98_16765	COG0488	(ABC) transporter
DGM98_16805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DGM98_16805	COG4651	solute:proton antiporter activity
DGM98_16815	COG4772	TonB-dependent receptor
DGM98_16825	COG4264	IucA IucC family
DGM98_16840	COG0019	diaminopimelate decarboxylase activity
DGM98_16865	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DGM98_16875	COG1492	cobalamin metabolic process
DGM98_16885	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DGM98_16910	COG4206	TonB-dependent receptor
DGM98_16915	COG0542	response to heat
DGM98_16920	COG1116	anion transmembrane transporter activity
DGM98_16925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DGM98_16930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DGM98_16935	COG0667	Aldo Keto reductase
DGM98_16940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DGM98_16945	COG4771	TonB-dependent receptor
DGM98_16950	COG2827	Endonuclease containing a URI domain
DGM98_16990	COG1877	trehalose-phosphatase activity
DGM98_16995	COG3387	PFAM Glycoside hydrolase 15-related
DGM98_17015	COG0840	transmembrane signaling receptor activity
DGM98_17020	COG3011	Protein conserved in bacteria
DGM98_17035	COG0564	pseudouridine synthase activity
DGM98_17040	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGM98_17050	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DGM98_17050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGM98_17065	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DGM98_17070	COG0045	succinate-CoA ligase (ADP-forming) activity
DGM98_17095	COG4969	Belongs to the N-Me-Phe pilin family
DGM98_17110	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DGM98_17115	COG0237	dephospho-CoA kinase activity
DGM98_17145	COG0745	RESPONSE REGULATOR receiver
DGM98_17155	COG0189	ligase activity
DGM98_17200	COG2022	thiamine diphosphate biosynthetic process
DGM98_17205	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DGM98_17210	COG0471	metal ion transport
DGM98_17210	COG3273	potassium ion transport
DGM98_17235	COG1970	mechanosensitive ion channel activity
DGM98_17245	COG1609	Transcriptional regulator
DGM98_17255	COG3250	beta-galactosidase activity
DGM98_17260	COG4948	Mandelate Racemase Muconate Lactonizing
DGM98_17270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DGM98_17280	COG0308	aminopeptidase N
DGM98_17285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGM98_17295	COG0529	Catalyzes the synthesis of activated sulfate
DGM98_17295	COG2895	sulfate adenylyltransferase (ATP) activity
DGM98_17300	COG0175	sulfate reduction
DGM98_17305	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGM98_17310	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DGM98_17315	COG0175	sulfate reduction
DGM98_17335	COG2205	protein histidine kinase activity
DGM98_17335	COG0784	Response regulator, receiver
DGM98_17335	COG2198	Histidine kinase
DGM98_17355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DGM98_17355	COG1648	precorrin-2 dehydrogenase activity
DGM98_17370	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DGM98_17375	COG3588	fructose-bisphosphate aldolase
DGM98_17390	COG0469	pyruvate kinase activity
DGM98_17400	COG0126	phosphoglycerate kinase activity
DGM98_17425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DGM98_17435	COG3047	cAMP biosynthetic process
DGM98_17440	COG3047	cAMP biosynthetic process
DGM98_17450	COG3453	Protein conserved in bacteria
DGM98_17450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGM98_17455	COG0725	ABC transporter, periplasmic molybdate-binding protein
DGM98_17460	COG4149	molybdate abc transporter
DGM98_17465	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DGM98_17500	COG1376	ErfK ybiS ycfS ynhG family protein
DGM98_17505	COG0739	heme binding
DGM98_17510	COG4773	Receptor
DGM98_17515	COG0596	Alpha beta hydrolase
DGM98_17520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DGM98_17525	COG1301	dicarboxylic acid transport
DGM98_17540	COG2304	oxidoreductase activity
DGM98_17560	COG0714	Associated with various cellular activities
DGM98_17590	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DGM98_17615	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DGM98_17625	COG2721	sulfolactate sulfo-lyase activity
DGM98_17640	COG2271	Major facilitator Superfamily
DGM98_17655	COG0583	DNA-binding transcription factor activity
DGM98_17660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DGM98_17675	COG1561	YicC-like family, N-terminal region
DGM98_17680	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DGM98_17690	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DGM98_17695	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DGM98_17710	COG0006	proline dipeptidase activity
DGM98_17720	COG0006	proline dipeptidase activity
DGM98_17725	COG3079	Belongs to the UPF0149 family
DGM98_17745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DGM98_17755	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DGM98_17765	COG2912	Transglutaminase-like superfamily
DGM98_17770	COG1773	rubredoxin
DGM98_17775	COG0352	thiamine-phosphate diphosphorylase activity
DGM98_17790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DGM98_17805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGM98_17835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DGM98_17840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGM98_17845	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_17855	COG0671	phosphoesterase, PA-phosphatase related
DGM98_17870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DGM98_17875	COG0563	adenylate kinase activity
DGM98_17890	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DGM98_17900	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DGM98_17920	COG3710	Transcriptional regulator
DGM98_17925	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DGM98_17940	COG0840	transmembrane signaling receptor activity
DGM98_17945	COG0405	Gamma-glutamyltransferase
DGM98_17950	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DGM98_17970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DGM98_17975	COG0473	3-isopropylmalate dehydrogenase activity
DGM98_17980	COG0066	3-isopropylmalate dehydratase activity
DGM98_17990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DGM98_18010	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DGM98_18015	COG1538	Outer membrane efflux protein
DGM98_18020	COG1519	Transferase
DGM98_18025	COG1560	Kdo2-lipid A biosynthetic process
DGM98_18075	COG0280	phosphate acetyltransferase
DGM98_18075	COG0281	malic enzyme
DGM98_18080	COG1301	dicarboxylic acid transport
DGM98_18105	COG0583	DNA-binding transcription factor activity
DGM98_18110	COG0667	Aldo Keto reductase
DGM98_18125	COG2197	response regulator
DGM98_18135	COG0642	Histidine kinase
DGM98_18155	COG2851	Citrate transporter
DGM98_18160	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_18165	COG1609	Transcriptional regulator
DGM98_18170	COG2211	Major facilitator Superfamily
DGM98_18200	COG1162	GTPase activity
DGM98_18235	COG0436	Aminotransferase
DGM98_18250	COG0726	polysaccharide deacetylase
DGM98_18255	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DGM98_18270	COG3964	amidohydrolase
DGM98_18275	COG0402	S-adenosylhomocysteine deaminase activity
DGM98_18295	COG1307	EDD domain protein, DegV family
DGM98_18300	COG0242	peptide deformylase activity
DGM98_18325	COG0457	Tetratricopeptide repeat
DGM98_18330	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DGM98_18335	COG1215	transferase activity, transferring glycosyl groups
DGM98_18340	COG1215	transferase activity, transferring glycosyl groups
DGM98_18355	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DGM98_18410	COG2188	Transcriptional regulator
DGM98_18420	COG1450	Type ii and iii secretion system protein
DGM98_18435	COG3166	PFAM Fimbrial assembly family protein
DGM98_18440	COG3156	type II secretion system protein K
DGM98_18445	COG4795	General secretion pathway protein
DGM98_18450	COG2165	general secretion pathway protein
DGM98_18455	COG4970	Tfp pilus assembly protein FimT
DGM98_18460	COG2165	general secretion pathway protein
DGM98_18465	COG1459	type II secretion system
DGM98_18475	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DGM98_18480	COG1404	Belongs to the peptidase S8 family
DGM98_18485	COG5295	Hep Hag repeat protein
DGM98_18490	COG1404	Belongs to the peptidase S8 family
DGM98_18495	COG5295	Hep Hag repeat protein
DGM98_18500	COG0047	phosphoribosylformylglycinamidine synthase activity
DGM98_18500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DGM98_18515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DGM98_18530	COG4974	Belongs to the 'phage' integrase family
DGM98_18545	COG0795	lipopolysaccharide-transporting ATPase activity
DGM98_18555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DGM98_18570	COG0525	valine-tRNA ligase activity
DGM98_18605	COG1183	phosphatidylcholine synthase activity
DGM98_18615	COG0442	prolyl-tRNA aminoacylation
DGM98_18630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DGM98_18635	COG1127	ABC transporter
DGM98_18640	COG3218	ABC-type transport auxiliary lipoprotein component
DGM98_18640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DGM98_18675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DGM98_18680	COG0662	Cupin 2, conserved barrel domain protein
DGM98_18680	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DGM98_18710	COG2086	electron transfer activity
DGM98_18730	COG3328	transposase activity
DGM98_18740	COG0277	FAD linked oxidase domain protein
DGM98_18755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGM98_18785	COG0438	transferase activity, transferring glycosyl groups
DGM98_18785	COG1216	Glycosyl transferase, family 2
DGM98_18805	COG0626	cystathionine gamma-synthase activity
DGM98_18835	COG0625	glutathione transferase activity
DGM98_18850	COG0513	Belongs to the DEAD box helicase family
DGM98_18860	COG4771	TonB-dependent receptor
DGM98_18870	COG0720	synthase
DGM98_18895	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DGM98_18900	COG1956	GAF domain-containing protein
DGM98_18910	COG2819	hydrolase of the alpha beta superfamily
DGM98_18920	COG0546	phosphoglycolate phosphatase activity
DGM98_18925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DGM98_18930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DGM98_18945	COG0339	signal peptide processing
DGM98_18995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DGM98_19000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGM98_19005	COG1136	(ABC) transporter
DGM98_19010	COG0577	efflux transmembrane transporter activity
DGM98_19015	COG0577	efflux transmembrane transporter activity
DGM98_19015	COG1136	(ABC) transporter
DGM98_19030	COG4191	Histidine kinase
DGM98_19035	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DGM98_19055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DGM98_19060	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DGM98_19065	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DGM98_19070	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DGM98_19075	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DGM98_19080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DGM98_19090	COG0356	it plays a direct role in the translocation of protons across the membrane
DGM98_19110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DGM98_19120	COG0508	dehydrogenase complex catalyzes the overall conversion of
DGM98_19160	COG2011	ABC-type metal ion transport system permease component
DGM98_19165	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DGM98_19170	COG0697	spore germination
DGM98_19175	COG1666	GTP binding
DGM98_19185	COG0784	Response regulator, receiver
DGM98_19185	COG5002	protein histidine kinase activity
DGM98_19185	COG2198	Histidine kinase
DGM98_19215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DGM98_19220	COG1187	pseudouridine synthase activity
DGM98_19225	COG2813	Specifically methylates the guanine in position
DGM98_19245	COG2202	Pas domain
DGM98_19245	COG2205	protein histidine kinase activity
DGM98_19265	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DGM98_19270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGM98_19330	COG0842	Transport permease protein
DGM98_19340	COG0025	NhaP-type Na H and K H
DGM98_19350	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DGM98_19355	COG1573	uracil-dna glycosylase
DGM98_19365	COG3384	dioxygenase
DGM98_19375	COG0583	DNA-binding transcription factor activity
DGM98_19385	COG0667	Aldo Keto reductase
DGM98_19400	COG3590	peptidase
DGM98_19415	COG0531	amino acid
DGM98_19430	COG2972	Histidine kinase
DGM98_19450	COG3685	Protein conserved in bacteria
DGM98_19455	COG3546	catalase activity
DGM98_19490	COG2204	response regulator
DGM98_19505	COG1271	oxidase subunit
DGM98_19510	COG1294	oxidase, subunit
DGM98_19525	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_19530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DGM98_19550	COG1132	(ABC) transporter
DGM98_19565	COG1063	alcohol dehydrogenase
DGM98_19655	COG0840	transmembrane signaling receptor activity
DGM98_19670	COG0583	DNA-binding transcription factor activity
DGM98_19675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DGM98_19705	COG0659	secondary active sulfate transmembrane transporter activity
DGM98_19720	COG0024	Methionine aminopeptidase
DGM98_19750	COG1487	ribonuclease activity
DGM98_19825	COG4974	Belongs to the 'phage' integrase family
DGM98_19890	COG1196	nuclear chromosome segregation
DGM98_19920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DGM98_19925	COG1490	D-aminoacyl-tRNA deacylase activity
DGM98_19930	COG1560	Kdo2-lipid A biosynthetic process
DGM98_19985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DGM98_19985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DGM98_19990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DGM98_19995	COG0242	peptide deformylase activity
DGM98_20000	COG1652	LysM domain
DGM98_20005	COG0758	DNA mediated transformation
DGM98_20025	COG1754	DNA topoisomerase type I activity
DGM98_20025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DGM98_20030	COG0009	L-threonylcarbamoyladenylate synthase
DGM98_20045	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_20060	COG0616	signal peptide processing
DGM98_20065	COG0534	Mate efflux family protein
DGM98_20085	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DGM98_20090	COG0625	glutathione transferase activity
DGM98_20105	COG1252	NADH dehydrogenase
DGM98_20110	COG2860	membrane
DGM98_20115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DGM98_20120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DGM98_20125	COG3437	response regulator, receiver
DGM98_20130	COG2177	Part of the ABC transporter FtsEX involved in
DGM98_20135	COG2884	Cell division ATP-binding protein ftsE
DGM98_20140	COG0513	Belongs to the DEAD box helicase family
DGM98_20145	COG3118	belongs to the thioredoxin family
DGM98_20150	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DGM98_20155	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
DGM98_20160	COG0583	DNA-binding transcription factor activity
DGM98_20180	COG1652	LysM domain
DGM98_20185	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DGM98_20185	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DGM98_20190	COG1473	amidohydrolase
DGM98_20195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGM98_20200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGM98_20220	COG5383	Protein conserved in bacteria
DGM98_20275	COG4948	Mandelate Racemase Muconate Lactonizing
DGM98_20285	COG0531	amino acid
DGM98_20300	COG4682	membrane
DGM98_20305	COG2133	pyrroloquinoline quinone binding
DGM98_20315	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DGM98_20320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DGM98_20330	COG1610	YqeY-like protein
DGM98_20340	COG1295	ribonuclease BN
DGM98_20345	COG0358	DNA primase activity
DGM98_20360	COG0109	protoheme IX farnesyltransferase activity
DGM98_20390	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DGM98_20405	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DGM98_20450	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DGM98_20455	COG0739	heme binding
DGM98_20460	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DGM98_20470	COG2223	nitrite transmembrane transporter activity
DGM98_20475	COG0708	Exodeoxyribonuclease III
DGM98_20480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DGM98_20490	COG1192	Involved in chromosome partitioning
DGM98_20495	COG1475	DNA binding
DGM98_20515	COG0463	Glycosyl transferase, family 2
DGM98_20535	COG0756	dUTP diphosphatase activity
DGM98_20540	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DGM98_20545	COG2003	Belongs to the UPF0758 family
DGM98_20550	COG0018	arginyl-trna synthetase
DGM98_20565	COG4221	oxidoreductase activity
DGM98_20570	COG2755	lipolytic protein G-D-S-L family
DGM98_20570	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DGM98_20580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGM98_20590	COG1166	arginine decarboxylase activity
DGM98_20595	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DGM98_20620	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DGM98_20620	COG3291	Pkd domain containing protein
DGM98_20640	COG0606	chelatase, subunit chli
DGM98_20655	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DGM98_20690	COG1690	Belongs to the RtcB family
DGM98_20725	COG1090	epimerase
DGM98_20735	COG0642	Histidine kinase
DGM98_20760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DGM98_20790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DGM98_20800	COG3328	transposase activity
DGM98_20810	COG0753	catalase activity
DGM98_20825	COG2197	response regulator
DGM98_20830	COG4585	Histidine kinase
DGM98_20835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGM98_20840	COG1136	(ABC) transporter
DGM98_20865	COG0697	spore germination
DGM98_20885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGM98_20890	COG0180	Tryptophanyl-tRNA synthetase
DGM98_20895	COG3237	CsbD-like
DGM98_20935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DGM98_20950	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DGM98_21000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DGM98_21030	COG1199	ATP-dependent helicase activity
DGM98_21045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DGM98_21120	COG0625	glutathione transferase activity
DGM98_21155	COG4555	ABC transporter
DGM98_21165	COG1476	TRANSCRIPTIONal
DGM98_21185	COG1230	cation diffusion facilitator family transporter
DGM98_21195	COG4774	siderophore transport
DGM98_21210	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGM98_21215	COG1131	(ABC) transporter
DGM98_21220	COG0842	Transport permease protein
DGM98_21225	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DGM98_21245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGM98_21255	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DGM98_21265	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DGM98_21280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DGM98_21280	COG1042	CoA-binding domain protein
DGM98_21280	COG0045	succinate-CoA ligase (ADP-forming) activity
DGM98_21285	COG2239	Acts as a magnesium transporter
DGM98_21305	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DGM98_21310	COG3387	PFAM Glycoside hydrolase 15-related
DGM98_21325	COG3100	YcgL domain-containing protein
DGM98_21330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DGM98_21340	COG0463	Glycosyl transferase, family 2
DGM98_21360	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_21400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DGM98_21415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGM98_21445	COG4946	Tricorn protease homolog
DGM98_21445	COG1506	peptidase
DGM98_21445	COG0823	Involved in the tonB-independent uptake of proteins
DGM98_21465	COG0408	coproporphyrinogen oxidase activity
DGM98_21500	COG0515	serine threonine protein kinase
DGM98_21505	COG0631	protein serine/threonine phosphatase activity
DGM98_21680	COG0210	DNA helicase
DGM98_21690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGM98_21695	COG0583	DNA-binding transcription factor activity
DGM98_21700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DGM98_21715	COG2159	amidohydrolase
DGM98_21745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGM98_21765	COG0357	Ribosomal RNA small subunit methyltransferase G
DGM98_21770	COG3540	Alkaline phosphatase
DGM98_21780	COG2091	lysine biosynthetic process via aminoadipic acid
DGM98_21795	COG0708	Exodeoxyribonuclease III
DGM98_21800	COG1940	carbohydrate kinase activity
DGM98_21800	COG1846	Transcriptional regulator
DGM98_21810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGM98_21825	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DGM98_21830	COG3162	membrane
DGM98_21840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DGM98_21870	COG3507	Belongs to the glycosyl hydrolase 43 family
DGM98_21890	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_21895	COG0179	Fumarylacetoacetate (FAA) hydrolase
DGM98_21900	COG4948	Mandelate Racemase Muconate Lactonizing
DGM98_21905	COG3254	rhamnose metabolic process
DGM98_21910	COG0738	Major facilitator superfamily
DGM98_21915	COG1414	Transcriptional regulator
DGM98_21920	COG1971	Probably functions as a manganese efflux pump
DGM98_21925	COG2205	protein histidine kinase activity
DGM98_21940	COG3459	Glycosyltransferase 36 associated
DGM98_21945	COG2211	Major facilitator Superfamily
DGM98_21950	COG3265	gluconokinase activity
DGM98_21960	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGM98_21980	COG2911	Protein conserved in bacteria
DGM98_21985	COG0729	surface antigen
DGM98_22015	COG0752	glycyl-tRNA synthetase alpha subunit
DGM98_22020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DGM98_22040	COG0519	Catalyzes the synthesis of GMP from XMP
DGM98_22040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DGM98_22050	COG0805	protein transport
DGM98_22055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DGM98_22060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DGM98_22070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DGM98_22090	COG2974	May be involved in recombination
DGM98_22095	COG0037	tRNA processing
DGM98_22100	COG2115	Belongs to the xylose isomerase family
DGM98_22110	COG3661	Belongs to the glycosyl hydrolase 67 family
DGM98_22120	COG4948	Mandelate Racemase Muconate Lactonizing
DGM98_22130	COG1472	Belongs to the glycosyl hydrolase 3 family
DGM98_22135	COG0246	Mannitol dehydrogenase
DGM98_22185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DGM98_22215	COG3386	PFAM SMP-30 Gluconolaconase
DGM98_22225	COG3250	beta-galactosidase activity
DGM98_22230	COG1904	glucuronate isomerase
DGM98_22245	COG3693	PFAM glycoside hydrolase, family 10
DGM98_22260	COG2211	Major facilitator Superfamily
DGM98_22315	COG0604	alcohol dehydrogenase
DGM98_22315	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_22315	COG3321	synthase
DGM98_22320	COG2937	Belongs to the GPAT DAPAT family
DGM98_22355	COG0284	orotidine-5'-phosphate decarboxylase activity
DGM98_22360	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DGM98_22370	COG3132	Protein of unknown function, DUF480
DGM98_22385	COG0210	DNA helicase
DGM98_22390	COG1435	thymidine kinase activity
DGM98_22400	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DGM98_22410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DGM98_22440	COG3135	benzoate transporter
DGM98_22465	COG0676	glucose-6-phosphate 1-epimerase activity
DGM98_22475	COG3012	SEC-C Motif Domain Protein
DGM98_22480	COG0730	response to heat
DGM98_22500	COG0302	gtp cyclohydrolase
DGM98_22515	COG1566	PFAM secretion protein HlyD family protein
DGM98_22525	COG1289	transmembrane transporter activity
DGM98_22530	COG0477	Major facilitator Superfamily
DGM98_22540	COG0583	DNA-binding transcription factor activity
DGM98_22545	COG4221	oxidoreductase activity
DGM98_22555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGM98_22615	COG0564	pseudouridine synthase activity
DGM98_22655	COG1028	Short-chain dehydrogenase reductase Sdr
DGM98_22700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DGM98_22705	COG1074	ATP-dependent DNA helicase activity
DGM98_22710	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DGM98_22745	COG1127	ABC transporter
DGM98_22750	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DGM98_22755	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DGM98_22770	COG2853	Lipoprotein
DGM98_22780	COG0386	Belongs to the glutathione peroxidase family
DGM98_22790	COG1322	Protein conserved in bacteria
DGM98_22805	COG0625	glutathione transferase activity
DGM98_22815	COG0531	amino acid
DGM98_22820	COG3537	Alpha-1,2-mannosidase
DGM98_22835	COG3706	GGDEF domain
DGM98_22840	COG3835	regulator
DGM98_22865	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DGM98_22875	COG0861	Integral membrane protein TerC family
DGM98_22885	COG0584	glycerophosphoryl diester phosphodiesterase
DGM98_22900	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DGM98_22915	COG0706	membrane insertase activity
DGM98_22920	COG0594	ribonuclease P activity
DGM98_23030	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DGM98_23035	COG4691	Plasmid stability protein
DGM98_23040	COG1487	ribonuclease activity
DGM98_23110	COG3846	protein secretion by the type IV secretion system
DGM98_23120	COG3451	type IV secretory pathway VirB4
DGM98_23135	COG4962	Type ii secretion system protein e
DGM98_23160	COG3328	transposase activity