locus-tag	class	description
DGN02_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DGN02_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DGN02_00025	COG0187	DNA topoisomerase II activity
DGN02_00035	COG0501	Belongs to the peptidase M48B family
DGN02_00070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DGN02_00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN02_00130	COG0793	Belongs to the peptidase S41A family
DGN02_00135	COG4942	peptidase
DGN02_00145	COG2234	aminopeptidase activity
DGN02_00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN02_00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN02_00165	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN02_00175	COG1064	alcohol dehydrogenase
DGN02_00190	COG0493	'glutamate synthase
DGN02_00195	COG0070	glutamate synthase
DGN02_00195	COG0069	glutamate synthase activity
DGN02_00195	COG0067	glutamate synthase
DGN02_00290	COG1111	helicase
DGN02_00290	COG1205	dead DEAH box helicase
DGN02_00295	COG1272	protein, Hemolysin III
DGN02_00315	COG0300	oxidoreductase activity
DGN02_00320	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_00335	COG2249	NAD(P)H dehydrogenase (quinone) activity
DGN02_00370	COG3237	CsbD-like
DGN02_00420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGN02_00430	COG0477	Major facilitator Superfamily
DGN02_00480	COG0714	Associated with various cellular activities
DGN02_00515	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DGN02_00525	COG4772	TonB-dependent receptor
DGN02_00540	COG1012	belongs to the aldehyde dehydrogenase family
DGN02_00565	COG1304	FMN binding
DGN02_00580	COG4585	Histidine kinase
DGN02_00585	COG2197	response regulator
DGN02_00605	COG3710	Transcriptional regulator
DGN02_00610	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DGN02_00720	COG0366	Alpha amylase catalytic
DGN02_00725	COG0366	Alpha amylase catalytic
DGN02_00730	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGN02_00750	COG0657	acetylesterase activity
DGN02_00750	COG2755	lipolytic protein G-D-S-L family
DGN02_00760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DGN02_00775	COG3507	Belongs to the glycosyl hydrolase 43 family
DGN02_00780	COG1609	Transcriptional regulator
DGN02_00795	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DGN02_00800	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_00810	COG2755	lipolytic protein G-D-S-L family
DGN02_00820	COG3186	Phenylalanine-4-hydroxylase
DGN02_00825	COG1522	sequence-specific DNA binding
DGN02_00835	COG1752	Esterase of the alpha-beta hydrolase superfamily
DGN02_00845	COG1119	ATPase activity
DGN02_00860	COG1125	glycine betaine transport
DGN02_00875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DGN02_00905	COG0489	protein tyrosine kinase activity
DGN02_00910	COG2062	phosphohistidine phosphatase, SixA
DGN02_00920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN02_00965	COG1968	undecaprenyl-diphosphatase activity
DGN02_00975	COG0174	glutamine synthetase
DGN02_00980	COG0347	Belongs to the P(II) protein family
DGN02_00985	COG0004	ammonium transporteR
DGN02_00990	COG3852	Histidine kinase
DGN02_00995	COG2204	response regulator
DGN02_01000	COG2032	superoxide dismutase activity
DGN02_01005	COG2032	superoxide dismutase activity
DGN02_01010	COG0346	lactoylglutathione lyase activity
DGN02_01020	COG0183	Belongs to the thiolase family
DGN02_01055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DGN02_01060	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DGN02_01065	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DGN02_01080	COG0028	Belongs to the TPP enzyme family
DGN02_01085	COG2205	protein histidine kinase activity
DGN02_01110	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DGN02_01125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN02_01135	COG0596	Alpha beta hydrolase
DGN02_01140	COG0727	PFAM Uncharacterised protein family (UPF0153)
DGN02_01145	COG0318	PFAM AMP-dependent synthetase and ligase
DGN02_01150	COG0745	RESPONSE REGULATOR receiver
DGN02_01160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN02_01180	COG1181	Belongs to the D-alanine--D-alanine ligase family
DGN02_01195	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DGN02_01205	COG0564	pseudouridine synthase activity
DGN02_01225	COG1446	asparaginase
DGN02_01230	COG0339	signal peptide processing
DGN02_01270	COG0475	glutathione-regulated potassium exporter activity
DGN02_01275	COG0583	DNA-binding transcription factor activity
DGN02_01280	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DGN02_01285	COG2224	Isocitrate lyase
DGN02_01315	COG4770	biotin carboxylase activity
DGN02_01320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DGN02_01325	COG1960	acyl-CoA dehydrogenase activity
DGN02_01390	COG0697	spore germination
DGN02_01400	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DGN02_01405	COG1846	Transcriptional regulator
DGN02_01410	COG1764	response to oxidative stress
DGN02_01440	COG2130	NADP-dependent
DGN02_01455	COG1187	pseudouridine synthase activity
DGN02_01470	COG1643	Atp-dependent helicase
DGN02_01480	COG4807	Protein conserved in bacteria
DGN02_01485	COG2351	hydroxyisourate hydrolase activity
DGN02_01490	COG2072	flavoprotein involved in K transport
DGN02_01510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DGN02_01520	COG0583	DNA-binding transcription factor activity
DGN02_01555	COG2252	PERMEase
DGN02_01580	COG0084	hydrolase, TatD family'
DGN02_01590	COG0583	DNA-binding transcription factor activity
DGN02_01595	COG2814	Major facilitator Superfamily
DGN02_01605	COG2267	carboxylic ester hydrolase activity
DGN02_01610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DGN02_01615	COG1902	pentaerythritol trinitrate reductase activity
DGN02_01635	COG0745	RESPONSE REGULATOR receiver
DGN02_01640	COG2205	protein histidine kinase activity
DGN02_01645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN02_01670	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DGN02_01675	COG0583	DNA-binding transcription factor activity
DGN02_01705	COG0702	epimerase
DGN02_01710	COG1733	regulation of RNA biosynthetic process
DGN02_01740	COG0129	dihydroxy-acid dehydratase activity
DGN02_01755	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DGN02_01815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DGN02_01820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DGN02_01850	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DGN02_01855	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DGN02_01865	COG3485	protocatechuate 3,4-dioxygenase
DGN02_01870	COG3485	protocatechuate 3,4-dioxygenase
DGN02_01880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN02_01885	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DGN02_01895	COG1414	Transcriptional regulator
DGN02_01905	COG0657	acetylesterase activity
DGN02_01915	COG0445	tRNA wobble uridine modification
DGN02_01925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DGN02_01950	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_01955	COG2267	carboxylic ester hydrolase activity
DGN02_01965	COG0156	8-amino-7-oxononanoate synthase activity
DGN02_01970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DGN02_01975	COG1040	competence protein
DGN02_01985	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DGN02_02065	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DGN02_02145	COG1368	sulfuric ester hydrolase activity
DGN02_02155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DGN02_02160	COG2354	Protein conserved in bacteria
DGN02_02170	COG0297	glycogen (starch) synthase activity
DGN02_02175	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGN02_02180	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGN02_02205	COG0702	epimerase
DGN02_02210	COG1858	cytochrome C peroxidase
DGN02_02225	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_02260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN02_02265	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_02275	COG0513	Belongs to the DEAD box helicase family
DGN02_02280	COG0508	dehydrogenase complex catalyzes the overall conversion of
DGN02_02295	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DGN02_02310	COG3483	tryptophan 2,3-dioxygenase activity
DGN02_02315	COG3104	oligopeptide transport
DGN02_02335	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DGN02_02355	COG1320	monovalent cation:proton antiporter activity
DGN02_02360	COG2212	antiporter activity
DGN02_02370	COG0651	ATP synthesis coupled electron transport
DGN02_02375	COG1006	Multisubunit Na H antiporter MnhC subunit
DGN02_02380	COG2111	Na H antiporter
DGN02_02380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DGN02_02405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DGN02_02410	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DGN02_02425	COG0456	acetyltransferase
DGN02_02430	COG1597	lipid kinase activity
DGN02_02455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DGN02_02460	COG0134	indole-3-glycerol-phosphate synthase activity
DGN02_02470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGN02_02475	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DGN02_02485	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DGN02_02495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DGN02_02510	COG1051	belongs to the nudix hydrolase family
DGN02_02550	COG0316	Belongs to the HesB IscA family
DGN02_02565	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DGN02_02585	COG2814	Major facilitator Superfamily
DGN02_02595	COG2814	Major facilitator Superfamily
DGN02_02600	COG1289	transmembrane transporter activity
DGN02_02605	COG0151	Belongs to the GarS family
DGN02_02615	COG0138	bifunctional purine biosynthesis protein purh
DGN02_02620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DGN02_02625	COG2267	carboxylic ester hydrolase activity
DGN02_02630	COG2453	phosphatase
DGN02_02630	COG0671	phosphoesterase, PA-phosphatase related
DGN02_02655	COG4589	Belongs to the CDS family
DGN02_02660	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DGN02_02685	COG2264	protein methyltransferase activity
DGN02_02705	COG0439	Biotin carboxylase
DGN02_02715	COG0511	ligase activity, forming carbon-carbon bonds
DGN02_02720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DGN02_02730	COG1324	tolerance protein
DGN02_02740	COG2356	endonuclease I
DGN02_02750	COG0459	protein refolding
DGN02_02765	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DGN02_02780	COG3386	PFAM SMP-30 Gluconolaconase
DGN02_02790	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DGN02_02795	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DGN02_02820	COG0778	Nitroreductase
DGN02_02825	COG2353	YceI-like domain
DGN02_02855	COG3052	prosthetic group binding
DGN02_02880	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DGN02_02890	COG1802	Transcriptional regulator
DGN02_02975	COG3328	transposase activity
DGN02_03060	COG1082	Xylose isomerase domain protein TIM barrel
DGN02_03080	COG4221	oxidoreductase activity
DGN02_03095	COG4221	oxidoreductase activity
DGN02_03105	COG0435	Glutathione S-transferase
DGN02_03140	COG0823	Involved in the tonB-independent uptake of proteins
DGN02_03140	COG1506	peptidase
DGN02_03190	COG4305	rare lipoprotein A
DGN02_03195	COG5297	Belongs to the glycosyl hydrolase family 6
DGN02_03205	COG1113	amino acid transport
DGN02_03225	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DGN02_03280	COG0840	transmembrane signaling receptor activity
DGN02_03285	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN02_03285	COG5297	Belongs to the glycosyl hydrolase family 6
DGN02_03290	COG0659	secondary active sulfate transmembrane transporter activity
DGN02_03315	COG2943	transferase activity, transferring hexosyl groups
DGN02_03325	COG3275	phosphorelay sensor kinase activity
DGN02_03335	COG0181	hydroxymethylbilane synthase activity
DGN02_03365	COG1505	serine-type exopeptidase activity
DGN02_03370	COG0436	Aminotransferase
DGN02_03380	COG2832	Protein of unknown function (DUF454)
DGN02_03390	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DGN02_03400	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DGN02_03405	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DGN02_03410	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DGN02_03435	COG2226	methyltransferase
DGN02_03440	COG5001	Diguanylate cyclase
DGN02_03440	COG3300	MHYT domain
DGN02_03445	COG0308	aminopeptidase N
DGN02_03495	COG3284	Transcriptional regulator
DGN02_03500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGN02_03505	COG1077	Cell shape determining protein MreB Mrl
DGN02_03510	COG1792	Involved in formation and maintenance of cell shape
DGN02_03525	COG0772	Belongs to the SEDS family
DGN02_03535	COG2951	lytic endotransglycosylase activity
DGN02_03540	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DGN02_03550	COG1686	Belongs to the peptidase S11 family
DGN02_03560	COG2921	Belongs to the UPF0250 family
DGN02_03565	COG0321	lipoyl(octanoyl) transferase activity
DGN02_03570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DGN02_03585	COG0583	DNA-binding transcription factor activity
DGN02_03595	COG1056	cytidyltransferase-related domain
DGN02_03595	COG1051	belongs to the nudix hydrolase family
DGN02_03630	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DGN02_03635	COG0673	inositol 2-dehydrogenase activity
DGN02_03640	COG2823	Periplasmic or secreted lipoprotein
DGN02_03645	COG4251	negative regulation of phosphorylation
DGN02_03650	COG0784	Response regulator, receiver
DGN02_03655	COG4191	Histidine kinase
DGN02_03660	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DGN02_03715	COG1459	type II secretion system
DGN02_03735	COG4795	General secretion pathway protein
DGN02_03765	COG3250	beta-galactosidase activity
DGN02_03780	COG2188	Transcriptional regulator
DGN02_03790	COG1609	Transcriptional regulator
DGN02_03795	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DGN02_03800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DGN02_03815	COG0617	tRNA 3'-terminal CCA addition
DGN02_03820	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DGN02_03825	COG1012	belongs to the aldehyde dehydrogenase family
DGN02_03830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DGN02_03845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DGN02_03860	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DGN02_03865	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DGN02_03885	COG2205	protein histidine kinase activity
DGN02_03915	COG3791	Glutathione-dependent formaldehyde-activating
DGN02_03930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DGN02_03940	COG0697	spore germination
DGN02_03950	COG0488	(ABC) transporter
DGN02_03960	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DGN02_03965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DGN02_03975	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DGN02_03975	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DGN02_03995	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DGN02_04000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DGN02_04005	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DGN02_04030	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DGN02_04035	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DGN02_04040	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DGN02_04045	COG2205	protein histidine kinase activity
DGN02_04050	COG0745	RESPONSE REGULATOR receiver
DGN02_04055	COG0277	FAD linked oxidase domain protein
DGN02_04060	COG1988	membrane-bound metal-dependent
DGN02_04065	COG0792	nuclease activity
DGN02_04100	COG0275	rRNA processing
DGN02_04105	COG3116	cell division
DGN02_04120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DGN02_04125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DGN02_04130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DGN02_04140	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DGN02_04145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DGN02_04150	COG1181	Belongs to the D-alanine--D-alanine ligase family
DGN02_04155	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DGN02_04170	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DGN02_04180	COG0739	heme binding
DGN02_04185	COG0653	protein targeting
DGN02_04190	COG0494	nUDIX hydrolase
DGN02_04200	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DGN02_04215	COG3321	synthase
DGN02_04215	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_04215	COG0604	alcohol dehydrogenase
DGN02_04240	COG0366	Alpha amylase catalytic
DGN02_04275	COG2226	methyltransferase
DGN02_04280	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DGN02_04290	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DGN02_04330	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DGN02_04340	COG4106	trans-aconitate 2-methyltransferase activity
DGN02_04345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DGN02_04355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGN02_04360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DGN02_04370	COG0667	Aldo Keto reductase
DGN02_04400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DGN02_04405	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DGN02_04415	COG2175	clavaminate synthase activity
DGN02_04425	COG4181	ATPase activity
DGN02_04440	COG0642	Histidine kinase
DGN02_04450	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DGN02_04470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DGN02_04475	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DGN02_04490	COG3829	transcription factor binding
DGN02_04500	COG1116	anion transmembrane transporter activity
DGN02_04505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DGN02_04515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DGN02_04520	COG0431	NADPH-dependent FMN reductase
DGN02_04540	COG0747	negative chemotaxis
DGN02_04550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DGN02_04560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DGN02_04565	COG2967	ApaG domain
DGN02_04570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DGN02_04575	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DGN02_04580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGN02_04585	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DGN02_04590	COG0123	including yeast histone deacetylase and acetoin utilization protein
DGN02_04595	COG2096	Adenosyltransferase
DGN02_04610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN02_04615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN02_04645	COG3384	dioxygenase
DGN02_04650	COG0583	DNA-binding transcription factor activity
DGN02_04665	COG1024	Enoyl-CoA hydratase
DGN02_04695	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DGN02_04720	COG0697	spore germination
DGN02_04730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGN02_04755	COG2197	response regulator
DGN02_04765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DGN02_04775	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DGN02_04780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGN02_04790	COG0583	DNA-binding transcription factor activity
DGN02_04795	COG3634	alkyl hydroperoxide reductase activity
DGN02_04805	COG2890	protein-(glutamine-N5) methyltransferase activity
DGN02_04825	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DGN02_04825	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DGN02_04855	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DGN02_04880	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DGN02_04900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DGN02_04905	COG1404	Belongs to the peptidase S8 family
DGN02_04910	COG1404	Belongs to the peptidase S8 family
DGN02_04915	COG1404	Belongs to the peptidase S8 family
DGN02_04920	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DGN02_04945	COG1295	ribonuclease BN
DGN02_04950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGN02_04970	COG0521	Mo-molybdopterin cofactor biosynthetic process
DGN02_04980	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DGN02_04985	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DGN02_04995	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DGN02_05000	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DGN02_05010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DGN02_05015	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DGN02_05020	COG0193	aminoacyl-tRNA hydrolase activity
DGN02_05025	COG0012	GTP binding
DGN02_05045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DGN02_05060	COG0250	Participates in transcription elongation, termination and antitermination
DGN02_05065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DGN02_05070	COG0081	regulation of translation
DGN02_05075	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DGN02_05080	COG0222	ribosome binding
DGN02_05085	COG0085	RNA polymerase activity
DGN02_05090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DGN02_05095	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DGN02_05100	COG0049	tRNA binding
DGN02_05105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DGN02_05110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DGN02_05115	COG0051	transcription antitermination factor activity, RNA binding
DGN02_05120	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DGN02_05125	COG0088	Forms part of the polypeptide exit tunnel
DGN02_05130	COG0089	rRNA binding
DGN02_05135	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DGN02_05140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DGN02_05150	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DGN02_05155	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DGN02_05160	COG0255	Belongs to the universal ribosomal protein uL29 family
DGN02_05165	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DGN02_05175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DGN02_05180	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DGN02_05190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DGN02_05195	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DGN02_05200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DGN02_05210	COG1841	ribosomal large subunit assembly
DGN02_05215	COG0200	Binds to the 23S rRNA
DGN02_05220	COG0201	protein transport
DGN02_05245	COG0203	ribosomal protein L17
DGN02_05250	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DGN02_05270	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DGN02_05285	COG0154	amidase activity
DGN02_05295	COG1217	gtp-binding protein TYPA
DGN02_05300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DGN02_05305	COG0039	L-malate dehydrogenase activity
DGN02_05310	COG0625	glutathione transferase activity
DGN02_05325	COG0446	pyridine nucleotide-disulphide oxidoreductase
DGN02_05325	COG1902	pentaerythritol trinitrate reductase activity
DGN02_05360	COG0156	8-amino-7-oxononanoate synthase activity
DGN02_05365	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DGN02_05370	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DGN02_05375	COG4208	sulfate ABC transporter
DGN02_05380	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DGN02_05410	COG0406	alpha-ribazole phosphatase activity
DGN02_05415	COG0285	dihydrofolate synthase activity
DGN02_05435	COG2833	Protein of unknown function (DUF455)
DGN02_05455	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN02_05460	COG0671	phosphoesterase, PA-phosphatase related
DGN02_05465	COG0438	transferase activity, transferring glycosyl groups
DGN02_05475	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DGN02_05490	COG4783	chaperone-mediated protein folding
DGN02_05505	COG0473	3-isopropylmalate dehydrogenase activity
DGN02_05545	COG3328	transposase activity
DGN02_05705	COG3328	transposase activity
DGN02_05780	COG4695	Portal protein
DGN02_05835	COG2201	protein-glutamate methylesterase activity
DGN02_05840	COG3852	Histidine kinase
DGN02_05850	COG0544	peptidyl-prolyl cis-trans isomerase activity
DGN02_05860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DGN02_05890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGN02_05905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGN02_05915	COG0328	RNA-DNA hybrid ribonuclease activity
DGN02_05920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DGN02_05925	COG0631	protein serine/threonine phosphatase activity
DGN02_05940	COG0859	PFAM glycosyl transferase family 9
DGN02_05945	COG3642	lipopolysaccharide core region biosynthetic process
DGN02_05950	COG1234	tRNA 3'-trailer cleavage
DGN02_05955	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DGN02_05965	COG0315	cyclic pyranopterin monophosphate synthase activity
DGN02_05970	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DGN02_05975	COG0314	molybdopterin synthase activity
DGN02_05995	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DGN02_06000	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DGN02_06005	COG0537	adenosine 5'-monophosphoramidase activity
DGN02_06025	COG0714	Associated with various cellular activities
DGN02_06050	COG0424	maF-like protein
DGN02_06055	COG1399	metal-binding, possibly nucleic acid-binding protein
DGN02_06065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN02_06075	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DGN02_06095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DGN02_06100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DGN02_06125	COG3829	transcription factor binding
DGN02_06140	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DGN02_06170	COG2373	Large extracellular alpha-helical protein
DGN02_06190	COG4953	penicillin-binding protein 1C
DGN02_06200	COG0678	peroxiredoxin activity
DGN02_06220	COG0330	HflC and HflK could
DGN02_06225	COG0330	HflC and HflK could
DGN02_06235	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DGN02_06240	COG0308	aminopeptidase N
DGN02_06250	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_06255	COG1309	transcriptional regulator
DGN02_06325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DGN02_06335	COG3387	PFAM Glycoside hydrolase 15-related
DGN02_06340	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_06350	COG3537	Alpha-1,2-mannosidase
DGN02_06360	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_06405	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DGN02_06410	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DGN02_06415	COG2080	2 iron, 2 sulfur cluster binding
DGN02_06450	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DGN02_06465	COG0587	DNA-directed DNA polymerase activity
DGN02_06480	COG1297	OPT oligopeptide transporter protein
DGN02_06495	COG0823	Involved in the tonB-independent uptake of proteins
DGN02_06495	COG1506	peptidase
DGN02_06515	COG2207	Transcriptional regulator
DGN02_06515	COG1917	Cupin 2, conserved barrel domain protein
DGN02_06545	COG0753	catalase activity
DGN02_06550	COG0656	L-ascorbic acid biosynthetic process
DGN02_06560	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DGN02_06560	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DGN02_06565	COG2814	Major facilitator Superfamily
DGN02_06580	COG2194	sulfuric ester hydrolase activity
DGN02_06595	COG0745	RESPONSE REGULATOR receiver
DGN02_06600	COG0642	Histidine kinase
DGN02_06610	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DGN02_06615	COG2894	cell division
DGN02_06620	COG0850	regulation of cytokinetic process
DGN02_06635	COG4585	Histidine kinase
DGN02_06640	COG2197	response regulator
DGN02_06655	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DGN02_06685	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DGN02_06695	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DGN02_06715	COG1946	Acyl-CoA thioesterase
DGN02_06730	COG0824	Thioesterase
DGN02_06735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DGN02_06740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DGN02_06745	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DGN02_06750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DGN02_06755	COG0268	Binds directly to 16S ribosomal RNA
DGN02_06765	COG0196	riboflavin kinase activity
DGN02_06770	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DGN02_06775	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DGN02_06780	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DGN02_06795	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DGN02_06800	COG1845	cytochrome c oxidase, subunit III
DGN02_06805	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DGN02_06820	COG3152	Membrane
DGN02_06830	COG2207	Transcriptional regulator
DGN02_06835	COG0326	Molecular chaperone. Has ATPase activity
DGN02_06845	COG1366	Belongs to the anti-sigma-factor antagonist family
DGN02_06850	COG1366	Belongs to the anti-sigma-factor antagonist family
DGN02_06855	COG2172	sigma factor antagonist activity
DGN02_06880	COG4771	TonB-dependent receptor
DGN02_06890	COG5507	3-demethylubiquinone-9 3-methyltransferase
DGN02_06895	COG2205	protein histidine kinase activity
DGN02_06905	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DGN02_06910	COG4999	Histidine kinase
DGN02_06910	COG2205	protein histidine kinase activity
DGN02_06910	COG3850	Histidine kinase
DGN02_06910	COG3437	response regulator, receiver
DGN02_06915	COG0784	Response regulator, receiver
DGN02_06915	COG4191	Histidine kinase
DGN02_06940	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DGN02_06950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DGN02_06960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DGN02_06965	COG0228	four-way junction DNA binding
DGN02_06970	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DGN02_06975	COG0336	Belongs to the RNA methyltransferase TrmD family
DGN02_06980	COG0335	large ribosomal subunit rRNA binding
DGN02_06985	COG0534	Mate efflux family protein
DGN02_07010	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DGN02_07020	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DGN02_07030	COG3209	COG3209 Rhs family protein
DGN02_07065	COG2963	transposase activity
DGN02_07085	COG3250	beta-galactosidase activity
DGN02_07090	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DGN02_07110	COG1960	acyl-CoA dehydrogenase activity
DGN02_07115	COG1024	Enoyl-CoA hydratase
DGN02_07120	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DGN02_07150	COG0457	Tetratricopeptide repeat
DGN02_07160	COG1024	Enoyl-CoA hydratase
DGN02_07160	COG1250	3-hydroxyacyl-CoA dehydrogenase
DGN02_07175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DGN02_07180	COG0481	GTPase activity
DGN02_07195	COG0571	ribonuclease III activity
DGN02_07200	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DGN02_07205	COG1381	Involved in DNA repair and RecF pathway recombination
DGN02_07215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DGN02_07220	COG2954	triphosphatase activity
DGN02_07225	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DGN02_07230	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
DGN02_07235	COG3046	protein related to deoxyribodipyrimidine photolyase
DGN02_07240	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN02_07245	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DGN02_07250	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DGN02_07255	COG1278	Cold shock
DGN02_07260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN02_07270	COG1201	RNA secondary structure unwinding
DGN02_07275	COG1793	dna ligase
DGN02_07285	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DGN02_07285	COG1793	dna ligase
DGN02_07315	COG0183	Belongs to the thiolase family
DGN02_07340	COG1451	nucleotide metabolic process
DGN02_07360	COG5487	UPF0391 membrane protein
DGN02_07370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DGN02_07390	COG1077	Cell shape determining protein MreB Mrl
DGN02_07395	COG1047	Peptidyl-prolyl cis-trans
DGN02_07405	COG2824	Alkylphosphonate utilization operon protein PhnA
DGN02_07415	COG1902	pentaerythritol trinitrate reductase activity
DGN02_07420	COG2814	Major facilitator Superfamily
DGN02_07455	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DGN02_07455	COG0392	lysyltransferase activity
DGN02_07465	COG0251	oxidation-reduction process
DGN02_07470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DGN02_07485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DGN02_07510	COG1595	DNA-templated transcription, initiation
DGN02_07535	COG2878	Part of a membrane complex involved in electron transport
DGN02_07545	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGN02_07545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGN02_07560	COG1131	(ABC) transporter
DGN02_07565	COG0346	lactoylglutathione lyase activity
DGN02_07570	COG0833	amino acid
DGN02_07575	COG2040	homocysteine
DGN02_07585	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DGN02_07615	COG1695	Transcriptional regulator
DGN02_07635	COG1981	membrane
DGN02_07650	COG0825	malonyl-CoA metabolic process
DGN02_07665	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN02_07670	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN02_07675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DGN02_07680	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN02_07695	COG0750	zinc metalloprotease
DGN02_07700	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DGN02_07705	COG0575	Belongs to the CDS family
DGN02_07710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DGN02_07715	COG0233	cytoplasmic translational termination
DGN02_07720	COG0528	UMP kinase activity
DGN02_07730	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DGN02_07735	COG0052	Belongs to the universal ribosomal protein uS2 family
DGN02_07775	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DGN02_07785	COG1393	Belongs to the ArsC family
DGN02_07790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DGN02_07795	COG0367	asparagine synthase
DGN02_07805	COG4774	siderophore transport
DGN02_07820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DGN02_07850	COG1566	PFAM secretion protein HlyD family protein
DGN02_07855	COG2814	Major facilitator Superfamily
DGN02_07905	COG0339	signal peptide processing
DGN02_07915	COG0386	Belongs to the glutathione peroxidase family
DGN02_07970	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DGN02_07975	COG0084	hydrolase, TatD family'
DGN02_07990	COG1960	acyl-CoA dehydrogenase activity
DGN02_08010	COG0367	asparagine synthase
DGN02_08020	COG0305	Participates in initiation and elongation during chromosome replication
DGN02_08025	COG0415	Belongs to the DNA photolyase family
DGN02_08035	COG0583	DNA-binding transcription factor activity
DGN02_08080	COG3706	GGDEF domain
DGN02_08110	COG2003	Belongs to the UPF0758 family
DGN02_08155	COG3328	transposase activity
DGN02_08190	COG3328	transposase activity
DGN02_08220	COG2814	Major facilitator Superfamily
DGN02_08290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DGN02_08305	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN02_08320	COG0497	DNA recombination
DGN02_08325	COG1420	regulation of RNA biosynthetic process
DGN02_08330	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DGN02_08335	COG0443	Heat shock 70 kDa protein
DGN02_08340	COG0484	heat shock protein binding
DGN02_08350	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DGN02_08385	COG0583	DNA-binding transcription factor activity
DGN02_08395	COG1132	(ABC) transporter
DGN02_08420	COG0567	Dehydrogenase, E1 component
DGN02_08430	COG2850	peptidyl-arginine hydroxylation
DGN02_08450	COG1253	flavin adenine dinucleotide binding
DGN02_08485	COG1131	(ABC) transporter
DGN02_08490	COG1725	Transcriptional regulator
DGN02_08500	COG0386	Belongs to the glutathione peroxidase family
DGN02_08515	COG2900	Belongs to the SlyX family
DGN02_08540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGN02_08550	COG1410	methionine synthase
DGN02_08550	COG0646	methionine synthase
DGN02_08555	COG1410	methionine synthase
DGN02_08555	COG0646	methionine synthase
DGN02_08560	COG2226	methyltransferase
DGN02_08565	COG1960	acyl-CoA dehydrogenase activity
DGN02_08580	COG1960	acyl-CoA dehydrogenase activity
DGN02_08605	COG0557	exoribonuclease II activity
DGN02_08615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DGN02_08625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DGN02_08635	COG0704	Plays a role in the regulation of phosphate uptake
DGN02_08640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DGN02_08645	COG0581	inorganic phosphate transmembrane transporter activity
DGN02_08650	COG0573	inorganic phosphate transmembrane transporter activity
DGN02_08655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DGN02_08680	COG0659	secondary active sulfate transmembrane transporter activity
DGN02_08685	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DGN02_08695	COG1024	Enoyl-CoA hydratase
DGN02_08705	COG0494	nUDIX hydrolase
DGN02_08740	COG0488	(ABC) transporter
DGN02_08750	COG0116	Belongs to the methyltransferase superfamily
DGN02_08750	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DGN02_08755	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DGN02_08780	COG2925	Exonuclease
DGN02_08785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN02_08790	COG3844	kynureninase activity
DGN02_08800	COG0662	Cupin 2, conserved barrel domain protein
DGN02_08805	COG0288	reversible hydration of carbon dioxide
DGN02_08835	COG3328	transposase activity
DGN02_08900	COG0017	Asparaginyl-tRNA synthetase
DGN02_08910	COG0316	Belongs to the HesB IscA family
DGN02_08915	COG0360	Binds together with S18 to 16S ribosomal RNA
DGN02_08920	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DGN02_08925	COG0359	binds to the 23S rRNA
DGN02_08940	COG3115	cell septum assembly
DGN02_08950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGN02_08960	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DGN02_08975	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DGN02_08985	COG4993	Dehydrogenase
DGN02_08995	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DGN02_09005	COG2986	histidine ammonia-lyase
DGN02_09010	COG1228	amidohydrolase
DGN02_09050	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DGN02_09055	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DGN02_09060	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DGN02_09065	COG0077	Prephenate dehydratase
DGN02_09065	COG1605	Chorismate mutase
DGN02_09070	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DGN02_09090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DGN02_09095	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DGN02_09100	COG0583	DNA-binding transcription factor activity
DGN02_09170	COG0840	transmembrane signaling receptor activity
DGN02_09205	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DGN02_09210	COG0784	Response regulator, receiver
DGN02_09210	COG4191	Histidine kinase
DGN02_09225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGN02_09235	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DGN02_09245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DGN02_09260	COG1595	DNA-templated transcription, initiation
DGN02_09315	COG2244	polysaccharide biosynthetic process
DGN02_09345	COG2264	protein methyltransferase activity
DGN02_09370	COG1136	(ABC) transporter
DGN02_09380	COG0477	Major facilitator Superfamily
DGN02_09385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DGN02_09400	COG1253	flavin adenine dinucleotide binding
DGN02_09415	COG0306	phosphate transporter
DGN02_09440	COG0504	CTP synthase activity
DGN02_09455	COG0148	phosphopyruvate hydratase activity
DGN02_09460	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DGN02_09465	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DGN02_09470	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DGN02_09480	COG2840	Smr protein MutS2
DGN02_09485	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DGN02_09490	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DGN02_09495	COG1238	metal cluster binding
DGN02_09510	COG1534	Rna-binding protein
DGN02_09515	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DGN02_09525	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DGN02_09530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DGN02_09540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DGN02_09545	COG1546	Belongs to the CinA family
DGN02_09555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DGN02_09560	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DGN02_09570	COG2137	regulation of response to DNA damage stimulus
DGN02_09575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DGN02_09580	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DGN02_09600	COG1741	Belongs to the pirin family
DGN02_09605	COG0583	DNA-binding transcription factor activity
DGN02_09630	COG0351	phosphomethylpyrimidine kinase
DGN02_09645	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DGN02_09650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DGN02_09665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DGN02_09675	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DGN02_09680	COG3734	2-keto-3-deoxy-galactonokinase
DGN02_09690	COG4948	Mandelate Racemase Muconate Lactonizing
DGN02_09695	COG0800	Aldolase
DGN02_09735	COG1501	Belongs to the glycosyl hydrolase 31 family
DGN02_09745	COG1070	Carbohydrate kinase
DGN02_09750	COG2115	Belongs to the xylose isomerase family
DGN02_09755	COG0477	Major facilitator Superfamily
DGN02_09770	COG0860	N-Acetylmuramoyl-L-alanine amidase
DGN02_09775	COG1469	GTP cyclohydrolase I activity
DGN02_09795	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DGN02_09800	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DGN02_09805	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DGN02_09830	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN02_09845	COG4251	negative regulation of phosphorylation
DGN02_09845	COG5001	Diguanylate cyclase
DGN02_09845	COG2203	Gaf domain
DGN02_09845	COG3706	GGDEF domain
DGN02_09850	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN02_09855	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DGN02_09865	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DGN02_09870	COG0671	phosphoesterase, PA-phosphatase related
DGN02_09880	COG1794	racemase activity, acting on amino acids and derivatives
DGN02_09890	COG0697	spore germination
DGN02_09895	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DGN02_09900	COG0167	dihydroorotate dehydrogenase activity
DGN02_09915	COG1012	belongs to the aldehyde dehydrogenase family
DGN02_09935	COG1215	transferase activity, transferring glycosyl groups
DGN02_09940	COG0726	polysaccharide deacetylase
DGN02_09940	COG1649	PFAM Uncharacterised BCR, COG1649
DGN02_10030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGN02_10035	COG0124	histidyl-tRNA synthetase
DGN02_10045	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DGN02_10050	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DGN02_10055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGN02_10060	COG0131	Imidazoleglycerol-phosphate dehydratase
DGN02_10060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DGN02_10065	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DGN02_10070	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DGN02_10075	COG0107	imidazoleglycerol-phosphate synthase activity
DGN02_10080	COG0140	phosphoribosyl-ATP diphosphatase activity
DGN02_10080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DGN02_10095	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
DGN02_10100	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DGN02_10105	COG0235	Class ii aldolase
DGN02_10110	COG0531	amino acid
DGN02_10115	COG0531	amino acid
DGN02_10125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DGN02_10130	COG0277	FAD linked oxidase domain protein
DGN02_10150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DGN02_10195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DGN02_10200	COG2258	MOSC domain
DGN02_10205	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DGN02_10210	COG0505	Belongs to the CarA family
DGN02_10220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DGN02_10225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGN02_10235	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DGN02_10245	COG3279	Response regulator of the LytR AlgR family
DGN02_10255	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DGN02_10265	COG0784	Response regulator, receiver
DGN02_10265	COG2205	protein histidine kinase activity
DGN02_10265	COG2198	Histidine kinase
DGN02_10270	COG0784	Response regulator, receiver
DGN02_10270	COG2205	protein histidine kinase activity
DGN02_10270	COG2198	Histidine kinase
DGN02_10275	COG1024	Enoyl-CoA hydratase
DGN02_10280	COG0318	PFAM AMP-dependent synthetase and ligase
DGN02_10310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN02_10320	COG2201	protein-glutamate methylesterase activity
DGN02_10325	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DGN02_10335	COG0840	transmembrane signaling receptor activity
DGN02_10345	COG0835	chemotaxis
DGN02_10375	COG0840	transmembrane signaling receptor activity
DGN02_10380	COG0840	transmembrane signaling receptor activity
DGN02_10390	COG0840	transmembrane signaling receptor activity
DGN02_10400	COG0840	transmembrane signaling receptor activity
DGN02_10405	COG0840	transmembrane signaling receptor activity
DGN02_10410	COG0840	transmembrane signaling receptor activity
DGN02_10415	COG0840	transmembrane signaling receptor activity
DGN02_10430	COG0840	transmembrane signaling receptor activity
DGN02_10455	COG0745	RESPONSE REGULATOR receiver
DGN02_10465	COG0835	chemotaxis
DGN02_10475	COG1360	Flagellar Motor Protein
DGN02_10480	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DGN02_10505	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DGN02_10565	COG3328	transposase activity
DGN02_10580	COG2198	Histidine kinase
DGN02_10580	COG0643	Histidine kinase
DGN02_10580	COG0784	Response regulator, receiver
DGN02_10640	COG1684	flagellar biosynthetic protein fliR
DGN02_10665	COG3190	flagellar
DGN02_10715	COG1677	Flagellar hook-basal body complex protein FliE
DGN02_10750	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_10755	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_10760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN02_10780	COG2201	protein-glutamate methylesterase activity
DGN02_10810	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DGN02_10820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DGN02_10830	COG1705	Flagellar rod assembly protein muramidase FlgJ
DGN02_10830	COG3951	Flagellar rod assembly protein muramidase FlgJ
DGN02_10835	COG1706	bacterial-type flagellum-dependent cell motility
DGN02_10840	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DGN02_10850	COG4787	bacterial-type flagellum-dependent cell motility
DGN02_10860	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DGN02_10865	COG1558	bacterial-type flagellum-dependent cell motility
DGN02_10875	COG0835	chemotaxis
DGN02_10875	COG0784	Response regulator, receiver
DGN02_10895	COG5002	protein histidine kinase activity
DGN02_10925	COG2915	High frequency lysogenization protein hflD homolog
DGN02_10930	COG0482	sulfurtransferase activity
DGN02_10945	COG0542	response to heat
DGN02_10955	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DGN02_10965	COG0492	ferredoxin-NADP+ reductase activity
DGN02_10970	COG1674	ftsk spoiiie
DGN02_10980	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DGN02_10990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DGN02_10995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DGN02_11005	COG0183	Belongs to the thiolase family
DGN02_11010	COG1024	Enoyl-CoA hydratase
DGN02_11010	COG1250	3-hydroxyacyl-CoA dehydrogenase
DGN02_11025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DGN02_11035	COG1426	Protein conserved in bacteria
DGN02_11045	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN02_11050	COG1160	GTP binding
DGN02_11055	COG0303	'Molybdopterin
DGN02_11060	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DGN02_11100	COG0708	Exodeoxyribonuclease III
DGN02_11110	COG0303	'Molybdopterin
DGN02_11115	COG0746	molybdenum cofactor guanylyltransferase activity
DGN02_11145	COG1914	H( )-stimulated, divalent metal cation uptake system
DGN02_11165	COG0668	transmembrane transport
DGN02_11175	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DGN02_11190	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_11195	COG1183	phosphatidylcholine synthase activity
DGN02_11205	COG3243	poly(R)-hydroxyalkanoic acid synthase
DGN02_11220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN02_11220	COG0723	plastoquinol--plastocyanin reductase activity
DGN02_11230	COG2183	response to ionizing radiation
DGN02_11235	COG2205	protein histidine kinase activity
DGN02_11235	COG0784	Response regulator, receiver
DGN02_11300	COG0800	Aldolase
DGN02_11305	COG0129	dihydroxy-acid dehydratase activity
DGN02_11310	COG0363	glucosamine-6-phosphate deaminase activity
DGN02_11315	COG0837	glucose binding
DGN02_11320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DGN02_11330	COG0354	folic acid binding
DGN02_11345	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DGN02_11360	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DGN02_11365	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DGN02_11375	COG4591	ABC-type transport system involved in lipoprotein release permease component
DGN02_11380	COG1136	(ABC) transporter
DGN02_11395	COG0811	peptide transport
DGN02_11400	COG0848	biopolymer transport protein
DGN02_11405	COG1132	(ABC) transporter
DGN02_11410	COG1663	tetraacyldisaccharide 4'-kinase activity
DGN02_11415	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DGN02_11420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DGN02_11430	COG0322	excinuclease ABC activity
DGN02_11435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DGN02_11445	COG0582	viral genome integration into host DNA
DGN02_11460	COG0583	DNA-binding transcription factor activity
DGN02_11690	COG3328	transposase activity
DGN02_11740	COG2814	Major facilitator Superfamily
DGN02_11750	COG2816	NAD+ diphosphatase activity
DGN02_11760	COG1960	acyl-CoA dehydrogenase activity
DGN02_11775	COG0477	Major facilitator Superfamily
DGN02_11780	COG0583	DNA-binding transcription factor activity
DGN02_11990	COG3039	Transposase
DGN02_12000	COG2951	lytic endotransglycosylase activity
DGN02_12015	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DGN02_12030	COG0270	DNA (cytosine-5-)-methyltransferase activity
DGN02_12040	COG0629	single-stranded DNA binding
DGN02_12105	COG1002	Type II restriction enzyme, methylase subunits
DGN02_12110	COG1061	Type III restriction enzyme res subunit
DGN02_12115	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DGN02_12145	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DGN02_12165	COG1054	Belongs to the UPF0176 family
DGN02_12175	COG1530	ribonuclease E activity
DGN02_12185	COG3064	Membrane
DGN02_12190	COG0428	transporter
DGN02_12200	COG2154	pterin-4-alpha-carbinolamine dehydratase
DGN02_12205	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DGN02_12205	COG0316	Belongs to the HesB IscA family
DGN02_12255	COG2226	methyltransferase
DGN02_12255	COG1073	alpha beta
DGN02_12260	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DGN02_12265	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_12285	COG1136	(ABC) transporter
DGN02_12290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DGN02_12295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN02_12295	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_12295	COG3321	synthase
DGN02_12295	COG4221	oxidoreductase activity
DGN02_12300	COG3321	synthase
DGN02_12300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN02_12300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN02_12300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGN02_12300	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_12305	COG4221	oxidoreductase activity
DGN02_12305	COG3321	synthase
DGN02_12305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN02_12305	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_12305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN02_12305	COG3321	synthase
DGN02_12305	COG4221	oxidoreductase activity
DGN02_12305	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_12310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGN02_12310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN02_12310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN02_12310	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_12310	COG3321	synthase
DGN02_12315	COG3321	synthase
DGN02_12315	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_12315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGN02_12315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN02_12315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN02_12325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN02_12370	COG0583	DNA-binding transcription factor activity
DGN02_12410	COG3220	belongs to the UPF0276 family
DGN02_12435	COG3920	Histidine kinase
DGN02_12445	COG1238	metal cluster binding
DGN02_12475	COG3279	Response regulator of the LytR AlgR family
DGN02_12480	COG3275	phosphorelay sensor kinase activity
DGN02_12520	COG4566	intracellular signal transduction
DGN02_12530	COG5001	Diguanylate cyclase
DGN02_12550	COG3685	Protein conserved in bacteria
DGN02_12570	COG1648	precorrin-2 dehydrogenase activity
DGN02_12570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DGN02_12585	COG2814	Major facilitator Superfamily
DGN02_12600	COG1335	isochorismatase
DGN02_12615	COG2197	response regulator
DGN02_12630	COG0583	DNA-binding transcription factor activity
DGN02_12635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DGN02_12640	COG3002	Belongs to the UPF0753 family
DGN02_12645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DGN02_12645	COG0519	Catalyzes the synthesis of GMP from XMP
DGN02_12655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DGN02_12670	COG0475	glutathione-regulated potassium exporter activity
DGN02_12670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DGN02_12675	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DGN02_12685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DGN02_12690	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DGN02_12700	COG0776	regulation of translation
DGN02_12705	COG0539	negative regulation of cytoplasmic translation
DGN02_12710	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DGN02_12730	COG2957	Belongs to the agmatine deiminase family
DGN02_12735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGN02_12760	COG0395	ABC-type sugar transport system, permease component
DGN02_12765	COG1175	transmembrane transport
DGN02_12795	COG2350	Protein conserved in bacteria
DGN02_12800	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DGN02_12805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DGN02_12810	COG1187	pseudouridine synthase activity
DGN02_12835	COG0436	Aminotransferase
DGN02_12840	COG4133	protoheme IX ABC transporter activity
DGN02_12860	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DGN02_12865	COG1138	Cytochrome C-type biogenesis protein
DGN02_12885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN02_12890	COG1278	Cold shock
DGN02_12895	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DGN02_12900	COG4988	ABC transporter
DGN02_12910	COG1294	oxidase, subunit
DGN02_12940	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DGN02_12945	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DGN02_12955	COG0165	Argininosuccinate lyase
DGN02_12960	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DGN02_12970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DGN02_12975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DGN02_12985	COG0137	argininosuccinate synthase activity
DGN02_12990	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DGN02_13000	COG0215	cysteine-tRNA ligase activity
DGN02_13005	COG2166	iron-sulfur cluster assembly
DGN02_13020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DGN02_13025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DGN02_13045	COG4302	ethanolamine ammonia-lyase activity
DGN02_13095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DGN02_13100	COG0402	S-adenosylhomocysteine deaminase activity
DGN02_13110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DGN02_13115	COG1509	lysine 2,3-aminomutase activity
DGN02_13120	COG3300	MHYT domain
DGN02_13120	COG5001	Diguanylate cyclase
DGN02_13135	COG0483	inositol monophosphate 1-phosphatase activity
DGN02_13140	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DGN02_13160	COG0488	(ABC) transporter
DGN02_13165	COG0513	Belongs to the DEAD box helicase family
DGN02_13170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DGN02_13175	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DGN02_13185	COG0625	glutathione transferase activity
DGN02_13195	COG4681	YaeQ
DGN02_13200	COG2081	HI0933 family
DGN02_13210	COG0501	Belongs to the peptidase M48B family
DGN02_13215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGN02_13220	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_13245	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DGN02_13250	COG0860	N-Acetylmuramoyl-L-alanine amidase
DGN02_13255	COG0802	atpase or kinase
DGN02_13260	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DGN02_13260	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DGN02_13265	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DGN02_13270	COG1570	exodeoxyribonuclease VII activity
DGN02_13285	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DGN02_13330	COG0835	chemotaxis
DGN02_13335	COG0840	transmembrane signaling receptor activity
DGN02_13340	COG2094	Belongs to the DNA glycosylase MPG family
DGN02_13345	COG1201	RNA secondary structure unwinding
DGN02_13365	COG2969	positive regulation of protein catabolic process
DGN02_13370	COG0625	glutathione transferase activity
DGN02_13375	COG2857	Cytochrome c1
DGN02_13380	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DGN02_13385	COG0723	plastoquinol--plastocyanin reductase activity
DGN02_13395	COG0741	lytic transglycosylase activity
DGN02_13410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DGN02_13415	COG1702	phosphate starvation-inducible protein PhoH
DGN02_13425	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DGN02_13435	COG4535	Mg2 and Co2 transporter CorC
DGN02_13450	COG1012	belongs to the aldehyde dehydrogenase family
DGN02_13455	COG1177	transmembrane transport
DGN02_13460	COG1176	ABC-type spermidine putrescine transport system, permease component I
DGN02_13470	COG3842	ATPase activity
DGN02_13490	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DGN02_13505	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DGN02_13510	COG0174	glutamine synthetase
DGN02_13515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN02_13525	COG2703	oxygen carrier activity
DGN02_13530	COG0477	Major facilitator Superfamily
DGN02_13540	COG0243	molybdopterin cofactor binding
DGN02_13545	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DGN02_13550	COG2223	nitrite transmembrane transporter activity
DGN02_13565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DGN02_13575	COG2733	membrane
DGN02_13580	COG5002	protein histidine kinase activity
DGN02_13580	COG0784	Response regulator, receiver
DGN02_13580	COG2205	protein histidine kinase activity
DGN02_13595	COG0477	Major facilitator Superfamily
DGN02_13630	COG2902	Dehydrogenase
DGN02_13640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN02_13645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN02_13650	COG1609	Transcriptional regulator
DGN02_13655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DGN02_13655	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGN02_13660	COG1105	Belongs to the carbohydrate kinase PfkB family
DGN02_13665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DGN02_13665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DGN02_13710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DGN02_13720	COG1862	Preprotein translocase
DGN02_13725	COG0343	queuine tRNA-ribosyltransferase activity
DGN02_13730	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DGN02_13765	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DGN02_13770	COG3291	Pkd domain containing protein
DGN02_13775	COG0405	Gamma-glutamyltransferase
DGN02_13780	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DGN02_13795	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DGN02_13800	COG0742	ribosomal rna small subunit methyltransferase
DGN02_13805	COG0326	Molecular chaperone. Has ATPase activity
DGN02_13895	COG0531	amino acid
DGN02_13910	COG0006	proline dipeptidase activity
DGN02_13920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DGN02_13935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN02_13940	COG3938	Belongs to the proline racemase family
DGN02_13950	COG0552	protein localization to endoplasmic reticulum
DGN02_13955	COG1194	a g-specific adenine glycosylase
DGN02_13960	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
DGN02_13965	COG0784	Response regulator, receiver
DGN02_13965	COG4191	Histidine kinase
DGN02_13980	COG0322	excinuclease ABC activity
DGN02_13995	COG3040	lipid binding
DGN02_14005	COG1960	acyl-CoA dehydrogenase activity
DGN02_14015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DGN02_14035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN02_14040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGN02_14045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN02_14070	COG0438	transferase activity, transferring glycosyl groups
DGN02_14080	COG0438	transferase activity, transferring glycosyl groups
DGN02_14085	COG0438	transferase activity, transferring glycosyl groups
DGN02_14135	COG0072	phenylalanine-tRNA ligase activity
DGN02_14135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGN02_14140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DGN02_14155	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DGN02_14160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DGN02_14175	COG2190	(PTS) system
DGN02_14175	COG2211	Major facilitator Superfamily
DGN02_14185	COG1082	Xylose isomerase domain protein TIM barrel
DGN02_14200	COG0366	Alpha amylase catalytic
DGN02_14305	COG3702	type iv secretory pathway
DGN02_14325	COG2948	multi-organism process
DGN02_14345	COG3505	Type IV secretory pathway VirD4
DGN02_14360	COG0556	nucleotide-excision repair
DGN02_14365	COG4969	Belongs to the N-Me-Phe pilin family
DGN02_14400	COG4969	Belongs to the N-Me-Phe pilin family
DGN02_14405	COG1611	Belongs to the LOG family
DGN02_14420	COG2095	MarC family integral membrane protein
DGN02_14430	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DGN02_14465	COG1185	polyribonucleotide nucleotidyltransferase activity
DGN02_14470	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DGN02_14475	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DGN02_14480	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DGN02_14485	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DGN02_14490	COG0195	Participates in both transcription termination and antitermination
DGN02_14495	COG0779	Required for maturation of 30S ribosomal subunits
DGN02_14505	COG1007	ATP synthesis coupled electron transport
DGN02_14530	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGN02_14535	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DGN02_14545	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DGN02_14550	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DGN02_14555	COG0649	NAD binding
DGN02_14560	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGN02_14565	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGN02_14570	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGN02_14585	COG0149	triose-phosphate isomerase activity
DGN02_14590	COG4221	oxidoreductase activity
DGN02_14620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DGN02_14625	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DGN02_14630	COG0159	tryptophan synthase activity
DGN02_14640	COG0133	tryptophan synthase activity
DGN02_14650	COG0135	phosphoribosylanthranilate isomerase activity
DGN02_14655	COG0101	tRNA pseudouridine synthase activity
DGN02_14670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DGN02_14675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DGN02_14680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DGN02_14685	COG2890	protein-(glutamine-N5) methyltransferase activity
DGN02_14695	COG0688	phosphatidylethanolamine metabolic process
DGN02_14710	COG0433	COG0433 Predicted ATPase
DGN02_14715	COG0494	nUDIX hydrolase
DGN02_14730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGN02_14735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DGN02_14760	COG0717	Belongs to the dCTP deaminase family
DGN02_14770	COG0489	protein tyrosine kinase activity
DGN02_14795	COG3590	peptidase
DGN02_14800	COG3590	peptidase
DGN02_14820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DGN02_14825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN02_14830	COG2311	Membrane
DGN02_14835	COG1047	Peptidyl-prolyl cis-trans
DGN02_14840	COG0791	NLP P60 protein
DGN02_14845	COG0791	NLP P60 protein
DGN02_14855	COG4106	trans-aconitate 2-methyltransferase activity
DGN02_14860	COG1301	dicarboxylic acid transport
DGN02_14865	COG1785	Belongs to the alkaline phosphatase family
DGN02_14875	COG0037	tRNA processing
DGN02_14880	COG1722	exodeoxyribonuclease VII activity
DGN02_14885	COG0142	geranyltranstransferase activity
DGN02_14890	COG4104	PAAR repeat-containing protein
DGN02_14900	COG0312	modulator of DNA gyrase
DGN02_14905	COG3028	Belongs to the UPF0307 family
DGN02_14910	COG0312	modulator of DNA gyrase
DGN02_14920	COG3164	Protein of unknown function
DGN02_14930	COG0424	maF-like protein
DGN02_14935	COG2968	Membrane
DGN02_14950	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DGN02_14965	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DGN02_14980	COG0495	leucyl-tRNA aminoacylation
DGN02_14990	COG3118	belongs to the thioredoxin family
DGN02_15025	COG2155	Conserved Protein
DGN02_15070	COG1132	(ABC) transporter
DGN02_15095	COG1538	Outer membrane efflux protein
DGN02_15100	COG0745	RESPONSE REGULATOR receiver
DGN02_15105	COG5000	phosphorelay sensor kinase activity
DGN02_15105	COG5002	protein histidine kinase activity
DGN02_15110	COG0475	glutathione-regulated potassium exporter activity
DGN02_15120	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DGN02_15140	COG1187	pseudouridine synthase activity
DGN02_15145	COG5001	Diguanylate cyclase
DGN02_15145	COG5002	protein histidine kinase activity
DGN02_15155	COG1595	DNA-templated transcription, initiation
DGN02_15260	COG0667	Aldo Keto reductase
DGN02_15265	COG2814	Major facilitator Superfamily
DGN02_15270	COG0583	DNA-binding transcription factor activity
DGN02_15280	COG2207	Transcriptional regulator
DGN02_15290	COG1309	transcriptional regulator
DGN02_15300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN02_15315	COG0735	belongs to the Fur family
DGN02_15320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGN02_15345	COG4452	Inner membrane protein CreD
DGN02_15360	COG0745	RESPONSE REGULATOR receiver
DGN02_15365	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DGN02_15375	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DGN02_15385	COG0643	Histidine kinase
DGN02_15385	COG2198	Histidine kinase
DGN02_15390	COG0840	transmembrane signaling receptor activity
DGN02_15395	COG0835	chemotaxis
DGN02_15405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DGN02_15415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN02_15420	COG3590	peptidase
DGN02_15430	COG0588	phosphoglycerate mutase activity
DGN02_15435	COG1515	deoxyribonuclease V activity
DGN02_15445	COG1741	Belongs to the pirin family
DGN02_15460	COG1741	Belongs to the pirin family
DGN02_15465	COG1966	Carbon starvation protein
DGN02_15470	COG2879	small protein
DGN02_15520	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DGN02_15525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DGN02_15530	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DGN02_15535	COG2080	2 iron, 2 sulfur cluster binding
DGN02_15540	COG0604	alcohol dehydrogenase
DGN02_15540	COG3321	synthase
DGN02_15540	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_15545	COG5001	Diguanylate cyclase
DGN02_15545	COG2203	Gaf domain
DGN02_15545	COG3706	GGDEF domain
DGN02_15545	COG4251	negative regulation of phosphorylation
DGN02_15550	COG0629	single-stranded DNA binding
DGN02_15555	COG0142	geranyltranstransferase activity
DGN02_15570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DGN02_15585	COG0527	aspartate kinase activity
DGN02_15595	COG0384	phenazine biosynthesis protein PhzF
DGN02_15605	COG1764	response to oxidative stress
DGN02_15610	COG0540	Belongs to the ATCase OTCase family
DGN02_15615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DGN02_15620	COG1678	Uncharacterized ACR, COG1678
DGN02_15630	COG0519	Catalyzes the synthesis of GMP from XMP
DGN02_15660	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DGN02_15675	COG0739	heme binding
DGN02_15695	COG0693	protein deglycase activity
DGN02_15705	COG1959	2 iron, 2 sulfur cluster binding
DGN02_15710	COG0719	Fe-S assembly protein
DGN02_15715	COG0396	ATPase activity
DGN02_15720	COG0719	Fe-S assembly protein
DGN02_15725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DGN02_15735	COG2146	nitrite reductase [NAD(P)H] activity
DGN02_15745	COG3128	pkhd-type hydroxylase
DGN02_15770	COG1477	protein flavinylation
DGN02_15775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGN02_15785	COG1555	photosystem II stabilization
DGN02_15800	COG3178	'Phosphotransferase
DGN02_15805	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DGN02_15825	COG0628	permease
DGN02_15835	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DGN02_15845	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DGN02_15865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DGN02_15870	COG0271	Belongs to the BolA IbaG family
DGN02_15880	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DGN02_15890	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DGN02_15895	COG1137	ATPase activity
DGN02_15910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGN02_15915	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DGN02_15920	COG1660	Displays ATPase and GTPase activities
DGN02_15930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGN02_15935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DGN02_15940	COG2239	Acts as a magnesium transporter
DGN02_15950	COG1294	oxidase, subunit
DGN02_15955	COG1271	oxidase subunit
DGN02_15965	COG1113	amino acid transport
DGN02_15995	COG2197	response regulator
DGN02_16000	COG0531	amino acid
DGN02_16105	COG2814	Major facilitator Superfamily
DGN02_16115	COG0754	glutathionylspermidine amidase activity
DGN02_16140	COG1842	Phage shock protein A
DGN02_16150	COG0259	pyridoxamine-phosphate oxidase activity
DGN02_16155	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DGN02_16160	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DGN02_16170	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DGN02_16175	COG2814	Major facilitator Superfamily
DGN02_16195	COG0784	Response regulator, receiver
DGN02_16195	COG2205	protein histidine kinase activity
DGN02_16195	COG2198	Histidine kinase
DGN02_16200	COG2353	YceI-like domain
DGN02_16220	COG1760	l-serine dehydratase
DGN02_16235	COG0460	homoserine dehydrogenase
DGN02_16235	COG0527	aspartate kinase activity
DGN02_16240	COG0626	cystathionine gamma-synthase activity
DGN02_16245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN02_16250	COG0739	heme binding
DGN02_16255	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DGN02_16260	COG1272	protein, Hemolysin III
DGN02_16265	COG2982	Protein involved in outer membrane biogenesis
DGN02_16270	COG0516	GMP reductase activity
DGN02_16270	COG0517	IMP dehydrogenase activity
DGN02_16275	COG0463	Glycosyl transferase, family 2
DGN02_16280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DGN02_16285	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DGN02_16295	COG4771	TonB-dependent receptor
DGN02_16300	COG1309	transcriptional regulator
DGN02_16310	COG1960	acyl-CoA dehydrogenase activity
DGN02_16335	COG0509	glycine decarboxylation via glycine cleavage system
DGN02_16340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DGN02_16350	COG1742	UPF0060 membrane protein
DGN02_16355	COG3956	TIGRFAM MazG family protein
DGN02_16360	COG1218	3'(2'),5'-bisphosphate nucleotidase
DGN02_16365	COG0494	nUDIX hydrolase
DGN02_16375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DGN02_16380	COG0837	glucose binding
DGN02_16395	COG1388	LysM domain
DGN02_16395	COG3858	chitin binding
DGN02_16410	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN02_16425	COG0531	amino acid
DGN02_16435	COG1486	melibiose metabolic process
DGN02_16445	COG3537	Alpha-1,2-mannosidase
DGN02_16485	COG3142	Participates in the control of copper homeostasis
DGN02_16490	COG1446	asparaginase
DGN02_16515	COG0643	Histidine kinase
DGN02_16515	COG0784	Response regulator, receiver
DGN02_16515	COG2198	Histidine kinase
DGN02_16520	COG0840	transmembrane signaling receptor activity
DGN02_16525	COG0835	chemotaxis
DGN02_16540	COG0189	ligase activity
DGN02_16550	COG1397	ADP-ribosylglycohydrolase
DGN02_16560	COG1199	ATP-dependent helicase activity
DGN02_16570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DGN02_16575	COG1216	Glycosyl transferase, family 2
DGN02_16590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DGN02_16600	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DGN02_16605	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DGN02_16610	COG0535	radical SAM domain protein
DGN02_16615	COG0535	radical SAM domain protein
DGN02_16630	COG0837	glucose binding
DGN02_16640	COG1643	Atp-dependent helicase
DGN02_16645	COG0783	Belongs to the Dps family
DGN02_16650	COG0514	ATP-dependent DNA helicase (RecQ)
DGN02_16690	COG0840	transmembrane signaling receptor activity
DGN02_16710	COG3920	Histidine kinase
DGN02_16715	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DGN02_16725	COG0602	queuosine metabolic process
DGN02_16735	COG2885	chlorophyll binding
DGN02_16740	COG0823	Involved in the tonB-independent uptake of proteins
DGN02_16750	COG0848	biopolymer transport protein
DGN02_16760	COG0824	Thioesterase
DGN02_16765	COG2255	four-way junction helicase activity
DGN02_16770	COG3158	transport of potassium into the cell
DGN02_16775	COG0632	four-way junction helicase activity
DGN02_16780	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DGN02_16785	COG0217	transcriptional regulatory protein
DGN02_16800	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DGN02_16815	COG0477	Major facilitator Superfamily
DGN02_16855	COG0488	(ABC) transporter
DGN02_16895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DGN02_16895	COG4651	solute:proton antiporter activity
DGN02_16905	COG4772	TonB-dependent receptor
DGN02_16915	COG4264	IucA IucC family
DGN02_16930	COG0019	diaminopimelate decarboxylase activity
DGN02_16960	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DGN02_16970	COG1492	cobalamin metabolic process
DGN02_16980	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DGN02_17005	COG4206	TonB-dependent receptor
DGN02_17010	COG0542	response to heat
DGN02_17015	COG1116	anion transmembrane transporter activity
DGN02_17020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DGN02_17025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DGN02_17030	COG0667	Aldo Keto reductase
DGN02_17035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DGN02_17040	COG4771	TonB-dependent receptor
DGN02_17045	COG2827	Endonuclease containing a URI domain
DGN02_17085	COG1877	trehalose-phosphatase activity
DGN02_17090	COG3387	PFAM Glycoside hydrolase 15-related
DGN02_17110	COG0840	transmembrane signaling receptor activity
DGN02_17115	COG3011	Protein conserved in bacteria
DGN02_17130	COG0564	pseudouridine synthase activity
DGN02_17135	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN02_17145	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DGN02_17145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGN02_17160	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DGN02_17165	COG0045	succinate-CoA ligase (ADP-forming) activity
DGN02_17225	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DGN02_17230	COG0237	dephospho-CoA kinase activity
DGN02_17280	COG0745	RESPONSE REGULATOR receiver
DGN02_17290	COG0189	ligase activity
DGN02_17325	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DGN02_17340	COG3328	transposase activity
DGN02_17440	COG0210	DNA helicase
DGN02_17530	COG2022	thiamine diphosphate biosynthetic process
DGN02_17535	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DGN02_17540	COG0471	metal ion transport
DGN02_17540	COG3273	potassium ion transport
DGN02_17565	COG1970	mechanosensitive ion channel activity
DGN02_17575	COG1609	Transcriptional regulator
DGN02_17585	COG3250	beta-galactosidase activity
DGN02_17590	COG4948	Mandelate Racemase Muconate Lactonizing
DGN02_17600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DGN02_17610	COG0308	aminopeptidase N
DGN02_17615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN02_17625	COG0529	Catalyzes the synthesis of activated sulfate
DGN02_17625	COG2895	sulfate adenylyltransferase (ATP) activity
DGN02_17630	COG0175	sulfate reduction
DGN02_17635	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGN02_17640	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DGN02_17645	COG0175	sulfate reduction
DGN02_17665	COG0784	Response regulator, receiver
DGN02_17665	COG2198	Histidine kinase
DGN02_17665	COG2205	protein histidine kinase activity
DGN02_17685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DGN02_17685	COG1648	precorrin-2 dehydrogenase activity
DGN02_17700	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DGN02_17705	COG3588	fructose-bisphosphate aldolase
DGN02_17720	COG0469	pyruvate kinase activity
DGN02_17730	COG0126	phosphoglycerate kinase activity
DGN02_17755	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DGN02_17765	COG3047	cAMP biosynthetic process
DGN02_17770	COG3047	cAMP biosynthetic process
DGN02_17780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGN02_17780	COG3453	Protein conserved in bacteria
DGN02_17785	COG0725	ABC transporter, periplasmic molybdate-binding protein
DGN02_17790	COG4149	molybdate abc transporter
DGN02_17795	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DGN02_17830	COG1376	ErfK ybiS ycfS ynhG family protein
DGN02_17835	COG0739	heme binding
DGN02_17840	COG4773	Receptor
DGN02_17850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DGN02_17855	COG1301	dicarboxylic acid transport
DGN02_17865	COG2304	oxidoreductase activity
DGN02_17885	COG0714	Associated with various cellular activities
DGN02_17915	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DGN02_17940	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DGN02_17950	COG2721	sulfolactate sulfo-lyase activity
DGN02_17965	COG2271	Major facilitator Superfamily
DGN02_17980	COG0583	DNA-binding transcription factor activity
DGN02_17985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DGN02_18000	COG1561	YicC-like family, N-terminal region
DGN02_18005	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DGN02_18015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DGN02_18020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DGN02_18035	COG0006	proline dipeptidase activity
DGN02_18045	COG0006	proline dipeptidase activity
DGN02_18050	COG3079	Belongs to the UPF0149 family
DGN02_18070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DGN02_18080	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DGN02_18090	COG2912	Transglutaminase-like superfamily
DGN02_18095	COG1773	rubredoxin
DGN02_18100	COG0352	thiamine-phosphate diphosphorylase activity
DGN02_18120	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DGN02_18135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGN02_18165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DGN02_18170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGN02_18175	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_18185	COG0671	phosphoesterase, PA-phosphatase related
DGN02_18190	COG3781	membrane
DGN02_18200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DGN02_18205	COG0563	adenylate kinase activity
DGN02_18220	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DGN02_18230	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DGN02_18250	COG3710	Transcriptional regulator
DGN02_18255	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DGN02_18270	COG0840	transmembrane signaling receptor activity
DGN02_18275	COG0405	Gamma-glutamyltransferase
DGN02_18280	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DGN02_18300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DGN02_18305	COG0473	3-isopropylmalate dehydrogenase activity
DGN02_18310	COG0066	3-isopropylmalate dehydratase activity
DGN02_18320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DGN02_18340	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DGN02_18345	COG1538	Outer membrane efflux protein
DGN02_18350	COG1519	Transferase
DGN02_18355	COG1560	Kdo2-lipid A biosynthetic process
DGN02_18380	COG0280	phosphate acetyltransferase
DGN02_18380	COG0281	malic enzyme
DGN02_18385	COG1301	dicarboxylic acid transport
DGN02_18410	COG0583	DNA-binding transcription factor activity
DGN02_18415	COG0667	Aldo Keto reductase
DGN02_18430	COG2197	response regulator
DGN02_18440	COG0642	Histidine kinase
DGN02_18460	COG2851	Citrate transporter
DGN02_18465	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_18470	COG1609	Transcriptional regulator
DGN02_18475	COG2211	Major facilitator Superfamily
DGN02_18505	COG1162	GTPase activity
DGN02_18510	COG0436	Aminotransferase
DGN02_18525	COG0726	polysaccharide deacetylase
DGN02_18530	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DGN02_18545	COG3964	amidohydrolase
DGN02_18550	COG0402	S-adenosylhomocysteine deaminase activity
DGN02_18570	COG1307	EDD domain protein, DegV family
DGN02_18575	COG0242	peptide deformylase activity
DGN02_18605	COG0457	Tetratricopeptide repeat
DGN02_18610	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DGN02_18615	COG1215	transferase activity, transferring glycosyl groups
DGN02_18620	COG1215	transferase activity, transferring glycosyl groups
DGN02_18635	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DGN02_18690	COG2188	Transcriptional regulator
DGN02_18700	COG1450	Type ii and iii secretion system protein
DGN02_18715	COG3166	PFAM Fimbrial assembly family protein
DGN02_18720	COG3156	type II secretion system protein K
DGN02_18725	COG4795	General secretion pathway protein
DGN02_18730	COG2165	general secretion pathway protein
DGN02_18735	COG4970	Tfp pilus assembly protein FimT
DGN02_18740	COG2165	general secretion pathway protein
DGN02_18745	COG1459	type II secretion system
DGN02_18755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DGN02_18760	COG1404	Belongs to the peptidase S8 family
DGN02_18765	COG5295	Hep Hag repeat protein
DGN02_18770	COG1404	Belongs to the peptidase S8 family
DGN02_18775	COG5295	Hep Hag repeat protein
DGN02_18780	COG0047	phosphoribosylformylglycinamidine synthase activity
DGN02_18780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DGN02_18795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DGN02_18810	COG4974	Belongs to the 'phage' integrase family
DGN02_18825	COG0795	lipopolysaccharide-transporting ATPase activity
DGN02_18835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DGN02_18850	COG0525	valine-tRNA ligase activity
DGN02_18885	COG1183	phosphatidylcholine synthase activity
DGN02_18895	COG0442	prolyl-tRNA aminoacylation
DGN02_18910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DGN02_18915	COG1127	ABC transporter
DGN02_18920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DGN02_18920	COG3218	ABC-type transport auxiliary lipoprotein component
DGN02_18950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DGN02_18955	COG0662	Cupin 2, conserved barrel domain protein
DGN02_18955	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DGN02_18985	COG2086	electron transfer activity
DGN02_19000	COG2226	methyltransferase
DGN02_19005	COG0463	Glycosyl transferase, family 2
DGN02_19025	COG0463	Glycosyl transferase, family 2
DGN02_19040	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DGN02_19065	COG0626	cystathionine gamma-synthase activity
DGN02_19095	COG0625	glutathione transferase activity
DGN02_19110	COG0513	Belongs to the DEAD box helicase family
DGN02_19120	COG4206	TonB-dependent receptor
DGN02_19130	COG0720	synthase
DGN02_19140	COG2015	COG2015, Alkyl sulfatase and related hydrolases
DGN02_19150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DGN02_19155	COG1956	GAF domain-containing protein
DGN02_19165	COG2819	hydrolase of the alpha beta superfamily
DGN02_19175	COG0546	phosphoglycolate phosphatase activity
DGN02_19180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DGN02_19185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DGN02_19200	COG0339	signal peptide processing
DGN02_19215	COG2132	Multicopper oxidase
DGN02_19250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DGN02_19255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN02_19260	COG1136	(ABC) transporter
DGN02_19265	COG0577	efflux transmembrane transporter activity
DGN02_19285	COG4191	Histidine kinase
DGN02_19290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DGN02_19305	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DGN02_19310	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DGN02_19315	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DGN02_19320	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DGN02_19325	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DGN02_19330	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DGN02_19340	COG0356	it plays a direct role in the translocation of protons across the membrane
DGN02_19360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DGN02_19370	COG0508	dehydrogenase complex catalyzes the overall conversion of
DGN02_19405	COG2011	ABC-type metal ion transport system permease component
DGN02_19410	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DGN02_19415	COG0697	spore germination
DGN02_19420	COG1666	GTP binding
DGN02_19430	COG5002	protein histidine kinase activity
DGN02_19430	COG2198	Histidine kinase
DGN02_19430	COG0784	Response regulator, receiver
DGN02_19450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DGN02_19455	COG1187	pseudouridine synthase activity
DGN02_19460	COG2813	Specifically methylates the guanine in position
DGN02_19480	COG2202	Pas domain
DGN02_19480	COG2205	protein histidine kinase activity
DGN02_19500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DGN02_19505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN02_19565	COG0842	Transport permease protein
DGN02_19570	COG1131	(ABC) transporter
DGN02_19575	COG0025	NhaP-type Na H and K H
DGN02_19585	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DGN02_19590	COG1573	uracil-dna glycosylase
DGN02_19600	COG3384	dioxygenase
DGN02_19610	COG0583	DNA-binding transcription factor activity
DGN02_19620	COG0667	Aldo Keto reductase
DGN02_19635	COG3590	peptidase
DGN02_19650	COG0531	amino acid
DGN02_19665	COG2972	Histidine kinase
DGN02_19690	COG3685	Protein conserved in bacteria
DGN02_19695	COG3546	catalase activity
DGN02_19730	COG2204	response regulator
DGN02_19745	COG1271	oxidase subunit
DGN02_19750	COG1294	oxidase, subunit
DGN02_19765	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_19770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DGN02_19790	COG1132	(ABC) transporter
DGN02_19805	COG1063	alcohol dehydrogenase
DGN02_19880	COG0251	oxidation-reduction process
DGN02_19895	COG0840	transmembrane signaling receptor activity
DGN02_19910	COG0583	DNA-binding transcription factor activity
DGN02_19915	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DGN02_19945	COG0659	secondary active sulfate transmembrane transporter activity
DGN02_19955	COG0024	Methionine aminopeptidase
DGN02_19985	COG1487	ribonuclease activity
DGN02_19995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN02_19995	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
DGN02_20000	COG3328	transposase activity
DGN02_20005	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
DGN02_20005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN02_20075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DGN02_20080	COG1490	D-aminoacyl-tRNA deacylase activity
DGN02_20085	COG1560	Kdo2-lipid A biosynthetic process
DGN02_20140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DGN02_20140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DGN02_20145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DGN02_20150	COG0242	peptide deformylase activity
DGN02_20155	COG1652	LysM domain
DGN02_20160	COG0758	DNA mediated transformation
DGN02_20180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DGN02_20180	COG1754	DNA topoisomerase type I activity
DGN02_20185	COG0009	L-threonylcarbamoyladenylate synthase
DGN02_20200	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_20215	COG0616	signal peptide processing
DGN02_20220	COG0534	Mate efflux family protein
DGN02_20240	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DGN02_20245	COG0625	glutathione transferase activity
DGN02_20260	COG1252	NADH dehydrogenase
DGN02_20265	COG2860	membrane
DGN02_20270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DGN02_20275	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DGN02_20280	COG3437	response regulator, receiver
DGN02_20285	COG2177	Part of the ABC transporter FtsEX involved in
DGN02_20290	COG2884	Cell division ATP-binding protein ftsE
DGN02_20295	COG0513	Belongs to the DEAD box helicase family
DGN02_20300	COG3118	belongs to the thioredoxin family
DGN02_20305	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DGN02_20310	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
DGN02_20315	COG0583	DNA-binding transcription factor activity
DGN02_20335	COG1652	LysM domain
DGN02_20340	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DGN02_20340	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DGN02_20345	COG1473	amidohydrolase
DGN02_20350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN02_20355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN02_20375	COG5383	Protein conserved in bacteria
DGN02_20430	COG4948	Mandelate Racemase Muconate Lactonizing
DGN02_20440	COG0531	amino acid
DGN02_20455	COG4682	membrane
DGN02_20460	COG2133	pyrroloquinoline quinone binding
DGN02_20470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DGN02_20475	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DGN02_20485	COG1610	YqeY-like protein
DGN02_20495	COG1295	ribonuclease BN
DGN02_20500	COG0358	DNA primase activity
DGN02_20515	COG0109	protoheme IX farnesyltransferase activity
DGN02_20545	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DGN02_20560	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DGN02_20605	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DGN02_20610	COG0739	heme binding
DGN02_20615	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DGN02_20625	COG2211	Major facilitator Superfamily
DGN02_20630	COG0708	Exodeoxyribonuclease III
DGN02_20635	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DGN02_20645	COG1192	Involved in chromosome partitioning
DGN02_20650	COG1475	DNA binding
DGN02_20670	COG0463	Glycosyl transferase, family 2
DGN02_20690	COG0756	dUTP diphosphatase activity
DGN02_20695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DGN02_20700	COG2003	Belongs to the UPF0758 family
DGN02_20705	COG0018	arginyl-trna synthetase
DGN02_20720	COG4221	oxidoreductase activity
DGN02_20725	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DGN02_20725	COG2755	lipolytic protein G-D-S-L family
DGN02_20745	COG1166	arginine decarboxylase activity
DGN02_20750	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DGN02_20775	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DGN02_20775	COG3291	Pkd domain containing protein
DGN02_20795	COG0606	chelatase, subunit chli
DGN02_20810	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DGN02_20845	COG1690	Belongs to the RtcB family
DGN02_20880	COG1090	epimerase
DGN02_20890	COG0642	Histidine kinase
DGN02_20915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DGN02_20940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DGN02_20945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DGN02_20975	COG2197	response regulator
DGN02_20980	COG4585	Histidine kinase
DGN02_20985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN02_20990	COG1136	(ABC) transporter
DGN02_21015	COG0697	spore germination
DGN02_21035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGN02_21040	COG0180	Tryptophanyl-tRNA synthetase
DGN02_21045	COG3237	CsbD-like
DGN02_21085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DGN02_21105	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DGN02_21155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DGN02_21185	COG1199	ATP-dependent helicase activity
DGN02_21200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DGN02_21280	COG0625	glutathione transferase activity
DGN02_21315	COG4555	ABC transporter
DGN02_21325	COG1476	TRANSCRIPTIONal
DGN02_21345	COG1230	cation diffusion facilitator family transporter
DGN02_21370	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGN02_21375	COG1131	(ABC) transporter
DGN02_21380	COG0842	Transport permease protein
DGN02_21385	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DGN02_21415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DGN02_21425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DGN02_21440	COG1042	CoA-binding domain protein
DGN02_21440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DGN02_21440	COG0045	succinate-CoA ligase (ADP-forming) activity
DGN02_21445	COG2239	Acts as a magnesium transporter
DGN02_21470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DGN02_21475	COG3387	PFAM Glycoside hydrolase 15-related
DGN02_21490	COG3100	YcgL domain-containing protein
DGN02_21495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DGN02_21505	COG0463	Glycosyl transferase, family 2
DGN02_21525	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_21565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DGN02_21580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGN02_21610	COG1506	peptidase
DGN02_21610	COG4946	Tricorn protease homolog
DGN02_21610	COG0823	Involved in the tonB-independent uptake of proteins
DGN02_21630	COG0408	coproporphyrinogen oxidase activity
DGN02_21670	COG0515	serine threonine protein kinase
DGN02_21675	COG0631	protein serine/threonine phosphatase activity
DGN02_21865	COG0210	DNA helicase
DGN02_21875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN02_21880	COG0583	DNA-binding transcription factor activity
DGN02_21885	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DGN02_21900	COG2159	amidohydrolase
DGN02_21930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN02_21950	COG0357	Ribosomal RNA small subunit methyltransferase G
DGN02_21955	COG3540	Alkaline phosphatase
DGN02_21965	COG2091	lysine biosynthetic process via aminoadipic acid
DGN02_21980	COG0708	Exodeoxyribonuclease III
DGN02_21985	COG1846	Transcriptional regulator
DGN02_21985	COG1940	carbohydrate kinase activity
DGN02_21995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGN02_22010	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DGN02_22015	COG3162	membrane
DGN02_22025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DGN02_22055	COG3507	Belongs to the glycosyl hydrolase 43 family
DGN02_22075	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_22080	COG0179	Fumarylacetoacetate (FAA) hydrolase
DGN02_22085	COG4948	Mandelate Racemase Muconate Lactonizing
DGN02_22090	COG3254	rhamnose metabolic process
DGN02_22095	COG0738	Major facilitator superfamily
DGN02_22100	COG1414	Transcriptional regulator
DGN02_22105	COG1971	Probably functions as a manganese efflux pump
DGN02_22110	COG2205	protein histidine kinase activity
DGN02_22125	COG3459	Glycosyltransferase 36 associated
DGN02_22130	COG2211	Major facilitator Superfamily
DGN02_22135	COG3265	gluconokinase activity
DGN02_22145	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN02_22170	COG2911	Protein conserved in bacteria
DGN02_22175	COG0729	surface antigen
DGN02_22205	COG0752	glycyl-tRNA synthetase alpha subunit
DGN02_22210	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DGN02_22225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DGN02_22225	COG0519	Catalyzes the synthesis of GMP from XMP
DGN02_22235	COG0805	protein transport
DGN02_22240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DGN02_22245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DGN02_22255	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DGN02_22275	COG2974	May be involved in recombination
DGN02_22280	COG0037	tRNA processing
DGN02_22285	COG2115	Belongs to the xylose isomerase family
DGN02_22295	COG3661	Belongs to the glycosyl hydrolase 67 family
DGN02_22305	COG4948	Mandelate Racemase Muconate Lactonizing
DGN02_22315	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN02_22320	COG0246	Mannitol dehydrogenase
DGN02_22370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DGN02_22400	COG3386	PFAM SMP-30 Gluconolaconase
DGN02_22410	COG3250	beta-galactosidase activity
DGN02_22415	COG1904	glucuronate isomerase
DGN02_22420	COG3693	PFAM glycoside hydrolase, family 10
DGN02_22430	COG3693	PFAM glycoside hydrolase, family 10
DGN02_22445	COG2211	Major facilitator Superfamily
DGN02_22480	COG0604	alcohol dehydrogenase
DGN02_22480	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_22480	COG3321	synthase
DGN02_22485	COG2937	Belongs to the GPAT DAPAT family
DGN02_22520	COG0284	orotidine-5'-phosphate decarboxylase activity
DGN02_22525	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DGN02_22535	COG3132	Protein of unknown function, DUF480
DGN02_22550	COG0210	DNA helicase
DGN02_22555	COG1435	thymidine kinase activity
DGN02_22565	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DGN02_22575	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DGN02_22605	COG3135	benzoate transporter
DGN02_22630	COG0676	glucose-6-phosphate 1-epimerase activity
DGN02_22640	COG3012	SEC-C Motif Domain Protein
DGN02_22645	COG0730	response to heat
DGN02_22675	COG0302	gtp cyclohydrolase
DGN02_22690	COG1566	PFAM secretion protein HlyD family protein
DGN02_22700	COG1289	transmembrane transporter activity
DGN02_22705	COG0477	Major facilitator Superfamily
DGN02_22715	COG0583	DNA-binding transcription factor activity
DGN02_22730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN02_22805	COG0564	pseudouridine synthase activity
DGN02_22845	COG1028	Short-chain dehydrogenase reductase Sdr
DGN02_22890	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DGN02_22895	COG1074	ATP-dependent DNA helicase activity
DGN02_22900	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DGN02_22940	COG1127	ABC transporter
DGN02_22945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DGN02_22950	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DGN02_22965	COG2853	Lipoprotein
DGN02_22975	COG0386	Belongs to the glutathione peroxidase family
DGN02_22985	COG1322	Protein conserved in bacteria
DGN02_23000	COG0625	glutathione transferase activity
DGN02_23010	COG0531	amino acid
DGN02_23015	COG3537	Alpha-1,2-mannosidase
DGN02_23030	COG3706	GGDEF domain
DGN02_23035	COG3835	regulator
DGN02_23040	COG1929	Belongs to the glycerate kinase type-1 family
DGN02_23045	COG2271	Major facilitator Superfamily
DGN02_23060	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DGN02_23070	COG0861	Integral membrane protein TerC family
DGN02_23080	COG0584	glycerophosphoryl diester phosphodiesterase
DGN02_23095	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DGN02_23110	COG0706	membrane insertase activity
DGN02_23115	COG0594	ribonuclease P activity
DGN02_23225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DGN02_23230	COG4691	Plasmid stability protein
DGN02_23235	COG1487	ribonuclease activity
DGN02_23305	COG3846	protein secretion by the type IV secretion system
DGN02_23315	COG3451	type IV secretory pathway VirB4
DGN02_23330	COG4962	Type ii secretion system protein e
DGN02_23355	COG3328	transposase activity