locus-tag	class	description
HZS93_00002	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HZS93_00004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZS93_00005	COG0187	DNA topoisomerase II activity
HZS93_00007	COG0501	Belongs to the peptidase M48B family
HZS93_00013	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HZS93_00015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZS93_00024	COG0793	Belongs to the peptidase S41A family
HZS93_00025	COG4942	peptidase
HZS93_00027	COG2234	aminopeptidase activity
HZS93_00029	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZS93_00031	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZS93_00033	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZS93_00035	COG1064	alcohol dehydrogenase
HZS93_00037	COG0493	'glutamate synthase
HZS93_00038	COG0070	glutamate synthase
HZS93_00038	COG0069	glutamate synthase activity
HZS93_00038	COG0067	glutamate synthase
HZS93_00042	COG2366	antibiotic biosynthetic process
HZS93_00048	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HZS93_00051	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HZS93_00052	COG0297	glycogen (starch) synthase activity
HZS93_00052	COG0438	transferase activity, transferring glycosyl groups
HZS93_00056	COG0367	asparagine synthase
HZS93_00062	COG1132	(ABC) transporter
HZS93_00068	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HZS93_00087	COG1111	helicase
HZS93_00087	COG1205	dead DEAH box helicase
HZS93_00088	COG1272	protein, Hemolysin III
HZS93_00092	COG0300	oxidoreductase activity
HZS93_00093	COG1028	Short-chain dehydrogenase reductase Sdr
HZS93_00098	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZS93_00100	COG2963	transposase activity
HZS93_00111	COG3237	CsbD-like
HZS93_00120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZS93_00122	COG0477	Major facilitator Superfamily
HZS93_00130	COG0714	Associated with various cellular activities
HZS93_00136	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HZS93_00138	COG4772	TonB-dependent receptor
HZS93_00140	COG0662	Cupin 2, conserved barrel domain protein
HZS93_00141	COG1012	belongs to the aldehyde dehydrogenase family
HZS93_00146	COG1304	FMN binding
HZS93_00149	COG4585	Histidine kinase
HZS93_00150	COG2197	response regulator
HZS93_00154	COG3710	Transcriptional regulator
HZS93_00155	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HZS93_00170	COG0366	Alpha amylase catalytic
HZS93_00171	COG0366	Alpha amylase catalytic
HZS93_00172	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HZS93_00177	COG2755	lipolytic protein G-D-S-L family
HZS93_00177	COG0657	acetylesterase activity
HZS93_00179	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HZS93_00182	COG3507	Belongs to the glycosyl hydrolase 43 family
HZS93_00183	COG1609	Transcriptional regulator
HZS93_00185	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HZS93_00186	COG1028	Short-chain dehydrogenase reductase Sdr
HZS93_00188	COG2755	lipolytic protein G-D-S-L family
HZS93_00191	COG3186	Phenylalanine-4-hydroxylase
HZS93_00192	COG1522	sequence-specific DNA binding
HZS93_00194	COG1752	Esterase of the alpha-beta hydrolase superfamily
HZS93_00196	COG1119	ATPase activity
HZS93_00199	COG1125	glycine betaine transport
HZS93_00202	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HZS93_00206	COG1396	sequence-specific DNA binding
HZS93_00211	COG0489	protein tyrosine kinase activity
HZS93_00212	COG2062	phosphohistidine phosphatase, SixA
HZS93_00214	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZS93_00224	COG1968	undecaprenyl-diphosphatase activity
HZS93_00226	COG0174	glutamine synthetase
HZS93_00227	COG0347	Belongs to the P(II) protein family
HZS93_00228	COG0004	ammonium transporteR
HZS93_00229	COG3852	Histidine kinase
HZS93_00230	COG2204	response regulator
HZS93_00231	COG2032	superoxide dismutase activity
HZS93_00232	COG2032	superoxide dismutase activity
HZS93_00234	COG0346	lactoylglutathione lyase activity
HZS93_00236	COG0183	Belongs to the thiolase family
HZS93_00243	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZS93_00244	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HZS93_00245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HZS93_00248	COG0028	Belongs to the TPP enzyme family
HZS93_00249	COG2205	protein histidine kinase activity
HZS93_00254	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HZS93_00257	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZS93_00259	COG0596	Alpha beta hydrolase
HZS93_00260	COG0727	PFAM Uncharacterised protein family (UPF0153)
HZS93_00261	COG0318	PFAM AMP-dependent synthetase and ligase
HZS93_00262	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZS93_00265	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZS93_00268	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HZS93_00270	COG0564	pseudouridine synthase activity
HZS93_00275	COG0339	signal peptide processing
HZS93_00281	COG0475	glutathione-regulated potassium exporter activity
HZS93_00282	COG0583	DNA-binding transcription factor activity
HZS93_00283	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HZS93_00284	COG2224	Isocitrate lyase
HZS93_00290	COG4770	biotin carboxylase activity
HZS93_00291	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZS93_00292	COG1960	acyl-CoA dehydrogenase activity
HZS93_00304	COG0523	cobalamin synthesis protein
HZS93_00306	COG0697	spore germination
HZS93_00308	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HZS93_00309	COG1846	Transcriptional regulator
HZS93_00310	COG1764	response to oxidative stress
HZS93_00316	COG2130	NADP-dependent
HZS93_00319	COG1187	pseudouridine synthase activity
HZS93_00322	COG1643	Atp-dependent helicase
HZS93_00324	COG4807	Protein conserved in bacteria
HZS93_00325	COG2351	hydroxyisourate hydrolase activity
HZS93_00326	COG2072	flavoprotein involved in K transport
HZS93_00330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HZS93_00337	COG1957	nucleoside hydrolase
HZS93_00339	COG2252	PERMEase
HZS93_00344	COG0084	hydrolase, TatD family'
HZS93_00347	COG0583	DNA-binding transcription factor activity
HZS93_00348	COG2814	Major facilitator Superfamily
HZS93_00351	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HZS93_00352	COG1902	pentaerythritol trinitrate reductase activity
HZS93_00356	COG0745	RESPONSE REGULATOR receiver
HZS93_00357	COG2205	protein histidine kinase activity
HZS93_00358	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS93_00362	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HZS93_00363	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HZS93_00364	COG0583	DNA-binding transcription factor activity
HZS93_00371	COG0702	epimerase
HZS93_00372	COG1733	regulation of RNA biosynthetic process
HZS93_00379	COG0129	dihydroxy-acid dehydratase activity
HZS93_00382	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HZS93_00394	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HZS93_00395	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HZS93_00400	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HZS93_00401	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HZS93_00403	COG3485	protocatechuate 3,4-dioxygenase
HZS93_00404	COG3485	protocatechuate 3,4-dioxygenase
HZS93_00406	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZS93_00407	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZS93_00410	COG1414	Transcriptional regulator
HZS93_00412	COG0657	acetylesterase activity
HZS93_00414	COG0445	tRNA wobble uridine modification
HZS93_00416	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZS93_00422	COG2267	carboxylic ester hydrolase activity
HZS93_00424	COG0156	8-amino-7-oxononanoate synthase activity
HZS93_00425	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZS93_00426	COG1040	competence protein
HZS93_00427	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HZS93_00445	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZS93_00459	COG3264	Mechanosensitive ion channel
HZS93_00459	COG1511	domain protein
HZS93_00460	COG1368	sulfuric ester hydrolase activity
HZS93_00462	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HZS93_00463	COG2354	Protein conserved in bacteria
HZS93_00465	COG0297	glycogen (starch) synthase activity
HZS93_00466	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HZS93_00467	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HZS93_00472	COG0702	epimerase
HZS93_00473	COG1028	Short-chain dehydrogenase reductase Sdr
HZS93_00480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZS93_00481	COG1028	Short-chain dehydrogenase reductase Sdr
HZS93_00484	COG0513	Belongs to the DEAD box helicase family
HZS93_00488	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HZS93_00490	COG3483	tryptophan 2,3-dioxygenase activity
HZS93_00491	COG3104	oligopeptide transport
HZS93_00495	COG2852	Protein conserved in bacteria
HZS93_00496	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HZS93_00500	COG1320	monovalent cation:proton antiporter activity
HZS93_00501	COG2212	antiporter activity
HZS93_00503	COG0651	ATP synthesis coupled electron transport
HZS93_00504	COG1006	Multisubunit Na H antiporter MnhC subunit
HZS93_00505	COG2111	Na H antiporter
HZS93_00505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HZS93_00511	COG3179	chitinase
HZS93_00515	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HZS93_00516	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HZS93_00519	COG0456	acetyltransferase
HZS93_00520	COG1597	lipid kinase activity
HZS93_00527	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZS93_00528	COG0134	indole-3-glycerol-phosphate synthase activity
HZS93_00530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZS93_00531	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HZS93_00533	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HZS93_00535	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HZS93_00538	COG1051	belongs to the nudix hydrolase family
HZS93_00546	COG0316	Belongs to the HesB IscA family
HZS93_00552	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HZS93_00555	COG2814	Major facilitator Superfamily
HZS93_00556	COG0583	DNA-binding transcription factor activity
HZS93_00557	COG2814	Major facilitator Superfamily
HZS93_00558	COG1289	transmembrane transporter activity
HZS93_00560	COG0151	Belongs to the GarS family
HZS93_00562	COG0138	bifunctional purine biosynthesis protein purh
HZS93_00563	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZS93_00564	COG2267	carboxylic ester hydrolase activity
HZS93_00565	COG2453	phosphatase
HZS93_00565	COG0671	phosphoesterase, PA-phosphatase related
HZS93_00570	COG4589	Belongs to the CDS family
HZS93_00571	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HZS93_00575	COG2264	protein methyltransferase activity
HZS93_00580	COG0439	Biotin carboxylase
HZS93_00582	COG0511	ligase activity, forming carbon-carbon bonds
HZS93_00583	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HZS93_00585	COG1324	tolerance protein
HZS93_00591	COG0300	oxidoreductase activity
HZS93_00592	COG2356	endonuclease I
HZS93_00595	COG0459	protein refolding
HZS93_00598	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HZS93_00601	COG3386	PFAM SMP-30 Gluconolaconase
HZS93_00603	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HZS93_00604	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HZS93_00608	COG0778	Nitroreductase
HZS93_00609	COG2353	YceI-like domain
HZS93_00615	COG3052	prosthetic group binding
HZS93_00620	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HZS93_00622	COG1802	Transcriptional regulator
HZS93_00634	COG4221	oxidoreductase activity
HZS93_00637	COG4221	oxidoreductase activity
HZS93_00639	COG0435	Glutathione S-transferase
HZS93_00644	COG2409	Drug exporters of the RND superfamily
HZS93_00646	COG0823	Involved in the tonB-independent uptake of proteins
HZS93_00646	COG1506	peptidase
HZS93_00654	COG0697	spore germination
HZS93_00657	COG1113	amino acid transport
HZS93_00661	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HZS93_00670	COG5001	Diguanylate cyclase
HZS93_00671	COG0840	transmembrane signaling receptor activity
HZS93_00672	COG5297	Belongs to the glycosyl hydrolase family 6
HZS93_00672	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZS93_00673	COG0659	secondary active sulfate transmembrane transporter activity
HZS93_00678	COG2943	transferase activity, transferring hexosyl groups
HZS93_00680	COG3275	phosphorelay sensor kinase activity
HZS93_00682	COG0181	hydroxymethylbilane synthase activity
HZS93_00688	COG1505	serine-type exopeptidase activity
HZS93_00689	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HZS93_00690	COG0436	Aminotransferase
HZS93_00693	COG2832	Protein of unknown function (DUF454)
HZS93_00695	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HZS93_00697	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HZS93_00698	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HZS93_00699	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HZS93_00704	COG2226	methyltransferase
HZS93_00705	COG3300	MHYT domain
HZS93_00705	COG5001	Diguanylate cyclase
HZS93_00706	COG0308	aminopeptidase N
HZS93_00716	COG3284	Transcriptional regulator
HZS93_00717	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZS93_00718	COG1077	Cell shape determining protein MreB Mrl
HZS93_00719	COG1792	Involved in formation and maintenance of cell shape
HZS93_00722	COG0772	Belongs to the SEDS family
HZS93_00724	COG2951	lytic endotransglycosylase activity
HZS93_00725	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HZS93_00727	COG1686	Belongs to the peptidase S11 family
HZS93_00729	COG2921	Belongs to the UPF0250 family
HZS93_00730	COG0321	lipoyl(octanoyl) transferase activity
HZS93_00731	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HZS93_00734	COG0583	DNA-binding transcription factor activity
HZS93_00736	COG1051	belongs to the nudix hydrolase family
HZS93_00736	COG1056	cytidyltransferase-related domain
HZS93_00743	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HZS93_00744	COG0673	inositol 2-dehydrogenase activity
HZS93_00745	COG2823	Periplasmic or secreted lipoprotein
HZS93_00746	COG4251	negative regulation of phosphorylation
HZS93_00747	COG0784	Response regulator, receiver
HZS93_00748	COG4191	Histidine kinase
HZS93_00749	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HZS93_00761	COG1459	type II secretion system
HZS93_00774	COG2188	Transcriptional regulator
HZS93_00776	COG1609	Transcriptional regulator
HZS93_00777	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZS93_00778	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HZS93_00780	COG0617	tRNA 3'-terminal CCA addition
HZS93_00781	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HZS93_00782	COG1012	belongs to the aldehyde dehydrogenase family
HZS93_00783	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HZS93_00786	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HZS93_00789	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HZS93_00790	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HZS93_00794	COG2205	protein histidine kinase activity
HZS93_00800	COG3791	Glutathione-dependent formaldehyde-activating
HZS93_00803	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZS93_00805	COG0697	spore germination
HZS93_00807	COG0488	(ABC) transporter
HZS93_00809	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZS93_00810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HZS93_00812	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZS93_00812	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZS93_00816	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HZS93_00817	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZS93_00818	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HZS93_00823	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HZS93_00824	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HZS93_00825	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HZS93_00826	COG2205	protein histidine kinase activity
HZS93_00827	COG0745	RESPONSE REGULATOR receiver
HZS93_00830	COG0277	FAD linked oxidase domain protein
HZS93_00831	COG1988	membrane-bound metal-dependent
HZS93_00832	COG0792	nuclease activity
HZS93_00839	COG0275	rRNA processing
HZS93_00840	COG3116	cell division
HZS93_00842	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZS93_00843	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HZS93_00844	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZS93_00846	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZS93_00847	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZS93_00848	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZS93_00849	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HZS93_00852	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HZS93_00854	COG0739	heme binding
HZS93_00855	COG0653	protein targeting
HZS93_00856	COG0494	nUDIX hydrolase
HZS93_00858	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HZS93_00861	COG0604	alcohol dehydrogenase
HZS93_00861	COG1028	Short-chain dehydrogenase reductase Sdr
HZS93_00861	COG3321	synthase
HZS93_00867	COG0366	Alpha amylase catalytic
HZS93_00873	COG2226	methyltransferase
HZS93_00874	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HZS93_00877	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HZS93_00887	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HZS93_00889	COG4106	trans-aconitate 2-methyltransferase activity
HZS93_00890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZS93_00892	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZS93_00893	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HZS93_00895	COG0667	Aldo Keto reductase
HZS93_00897	COG4771	TonB-dependent receptor
HZS93_00901	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZS93_00902	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HZS93_00904	COG2175	clavaminate synthase activity
HZS93_00906	COG4181	ATPase activity
HZS93_00909	COG0642	Histidine kinase
HZS93_00912	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HZS93_00916	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HZS93_00917	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HZS93_00920	COG3829	transcription factor binding
HZS93_00922	COG1116	anion transmembrane transporter activity
HZS93_00923	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZS93_00925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZS93_00926	COG0431	NADPH-dependent FMN reductase
HZS93_00931	COG0747	negative chemotaxis
HZS93_00933	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZS93_00935	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HZS93_00936	COG2967	ApaG domain
HZS93_00937	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HZS93_00938	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HZS93_00939	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZS93_00940	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HZS93_00943	COG0123	including yeast histone deacetylase and acetoin utilization protein
HZS93_00944	COG2096	Adenosyltransferase
HZS93_00947	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZS93_00948	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZS93_00954	COG3384	dioxygenase
HZS93_00955	COG0583	DNA-binding transcription factor activity
HZS93_00958	COG1024	Enoyl-CoA hydratase
HZS93_00962	COG3386	PFAM SMP-30 Gluconolaconase
HZS93_00965	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HZS93_00969	COG0697	spore germination
HZS93_00971	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZS93_00975	COG0784	Response regulator, receiver
HZS93_00975	COG5002	protein histidine kinase activity
HZS93_00975	COG2205	protein histidine kinase activity
HZS93_00976	COG2197	response regulator
HZS93_00978	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZS93_00980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZS93_00981	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZS93_00983	COG0583	DNA-binding transcription factor activity
HZS93_00984	COG3634	alkyl hydroperoxide reductase activity
HZS93_00986	COG2890	protein-(glutamine-N5) methyltransferase activity
HZS93_00990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZS93_00990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZS93_00996	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HZS93_01002	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HZS93_01005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZS93_01006	COG1404	Belongs to the peptidase S8 family
HZS93_01007	COG1404	Belongs to the peptidase S8 family
HZS93_01008	COG1404	Belongs to the peptidase S8 family
HZS93_01009	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HZS93_01011	COG5520	Belongs to the glycosyl hydrolase 30 family
HZS93_01014	COG1295	ribonuclease BN
HZS93_01015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZS93_01016	COG1254	Belongs to the acylphosphatase family
HZS93_01019	COG0521	Mo-molybdopterin cofactor biosynthetic process
HZS93_01021	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HZS93_01022	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HZS93_01024	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HZS93_01025	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HZS93_01027	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HZS93_01028	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HZS93_01029	COG0193	aminoacyl-tRNA hydrolase activity
HZS93_01030	COG0012	GTP binding
HZS93_01034	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZS93_01037	COG0250	Participates in transcription elongation, termination and antitermination
HZS93_01038	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HZS93_01039	COG0081	regulation of translation
HZS93_01040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HZS93_01041	COG0222	ribosome binding
HZS93_01042	COG0085	RNA polymerase activity
HZS93_01043	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HZS93_01044	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HZS93_01045	COG0049	tRNA binding
HZS93_01046	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HZS93_01047	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZS93_01048	COG0051	transcription antitermination factor activity, RNA binding
HZS93_01049	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HZS93_01050	COG0088	Forms part of the polypeptide exit tunnel
HZS93_01051	COG0089	rRNA binding
HZS93_01052	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HZS93_01053	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HZS93_01055	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HZS93_01056	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HZS93_01057	COG0255	Belongs to the universal ribosomal protein uL29 family
HZS93_01058	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HZS93_01060	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HZS93_01061	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HZS93_01063	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HZS93_01064	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HZS93_01065	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HZS93_01067	COG1841	ribosomal large subunit assembly
HZS93_01068	COG0200	Binds to the 23S rRNA
HZS93_01069	COG0201	protein transport
HZS93_01074	COG0203	ribosomal protein L17
HZS93_01075	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HZS93_01079	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HZS93_01081	COG0154	amidase activity
HZS93_01083	COG1217	gtp-binding protein TYPA
HZS93_01084	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZS93_01085	COG0039	L-malate dehydrogenase activity
HZS93_01086	COG0625	glutathione transferase activity
HZS93_01090	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZS93_01090	COG1902	pentaerythritol trinitrate reductase activity
HZS93_01091	COG0604	alcohol dehydrogenase
HZS93_01097	COG0156	8-amino-7-oxononanoate synthase activity
HZS93_01098	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HZS93_01099	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HZS93_01100	COG4208	sulfate ABC transporter
HZS93_01101	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HZS93_01103	COG1063	alcohol dehydrogenase
HZS93_01109	COG0406	alpha-ribazole phosphatase activity
HZS93_01110	COG0285	dihydrofolate synthase activity
HZS93_01114	COG2833	Protein of unknown function (DUF455)
HZS93_01116	COG3291	Pkd domain containing protein
HZS93_01118	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZS93_01119	COG0671	phosphoesterase, PA-phosphatase related
HZS93_01120	COG0438	transferase activity, transferring glycosyl groups
HZS93_01122	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HZS93_01125	COG4783	chaperone-mediated protein folding
HZS93_01128	COG0473	3-isopropylmalate dehydrogenase activity
HZS93_01136	COG2963	transposase activity
HZS93_01157	COG3852	Histidine kinase
HZS93_01159	COG0544	peptidyl-prolyl cis-trans isomerase activity
HZS93_01161	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HZS93_01167	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZS93_01169	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZS93_01171	COG0328	RNA-DNA hybrid ribonuclease activity
HZS93_01172	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HZS93_01173	COG0631	protein serine/threonine phosphatase activity
HZS93_01176	COG0859	PFAM glycosyl transferase family 9
HZS93_01177	COG3642	lipopolysaccharide core region biosynthetic process
HZS93_01178	COG1234	tRNA 3'-trailer cleavage
HZS93_01179	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HZS93_01181	COG0315	cyclic pyranopterin monophosphate synthase activity
HZS93_01182	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HZS93_01183	COG0314	molybdopterin synthase activity
HZS93_01194	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HZS93_01195	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HZS93_01196	COG0537	adenosine 5'-monophosphoramidase activity
HZS93_01200	COG0714	Associated with various cellular activities
HZS93_01205	COG0424	maF-like protein
HZS93_01206	COG1399	metal-binding, possibly nucleic acid-binding protein
HZS93_01207	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HZS93_01208	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZS93_01211	COG1028	Short-chain dehydrogenase reductase Sdr
HZS93_01214	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HZS93_01215	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HZS93_01220	COG3829	transcription factor binding
HZS93_01224	COG3609	addiction module antidote protein, CC2985 family
HZS93_01231	COG2373	Large extracellular alpha-helical protein
HZS93_01235	COG4953	penicillin-binding protein 1C
HZS93_01237	COG0678	peroxiredoxin activity
HZS93_01241	COG0330	HflC and HflK could
HZS93_01242	COG0330	HflC and HflK could
HZS93_01244	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HZS93_01245	COG0308	aminopeptidase N
HZS93_01246	COG1028	Short-chain dehydrogenase reductase Sdr
HZS93_01247	COG1309	transcriptional regulator
HZS93_01256	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HZS93_01263	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HZS93_01265	COG3387	PFAM Glycoside hydrolase 15-related
HZS93_01266	COG1028	Short-chain dehydrogenase reductase Sdr
HZS93_01268	COG3537	Alpha-1,2-mannosidase
HZS93_01272	COG0492	ferredoxin-NADP+ reductase activity
HZS93_01277	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZS93_01278	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HZS93_01279	COG2080	2 iron, 2 sulfur cluster binding
HZS93_01286	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HZS93_01289	COG0587	DNA-directed DNA polymerase activity
HZS93_01293	COG1297	OPT oligopeptide transporter protein
HZS93_01296	COG0823	Involved in the tonB-independent uptake of proteins
HZS93_01296	COG1506	peptidase
HZS93_01299	COG1917	Cupin 2, conserved barrel domain protein
HZS93_01299	COG2207	Transcriptional regulator
HZS93_01303	COG0753	catalase activity
HZS93_01304	COG0656	L-ascorbic acid biosynthetic process
HZS93_01306	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZS93_01306	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZS93_01307	COG2814	Major facilitator Superfamily
HZS93_01310	COG2194	sulfuric ester hydrolase activity
HZS93_01313	COG0745	RESPONSE REGULATOR receiver
HZS93_01314	COG0642	Histidine kinase
HZS93_01316	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HZS93_01317	COG2894	cell division
HZS93_01318	COG0850	regulation of cytokinetic process
HZS93_01321	COG4585	Histidine kinase
HZS93_01322	COG2197	response regulator
HZS93_01325	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HZS93_01331	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HZS93_01333	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HZS93_01337	COG1946	Acyl-CoA thioesterase
HZS93_01340	COG0824	Thioesterase
HZS93_01341	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZS93_01342	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HZS93_01343	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HZS93_01344	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HZS93_01345	COG0268	Binds directly to 16S ribosomal RNA
HZS93_01347	COG0196	riboflavin kinase activity
HZS93_01348	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HZS93_01349	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HZS93_01350	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HZS93_01353	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZS93_01354	COG1845	cytochrome c oxidase, subunit III
HZS93_01355	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HZS93_01358	COG3152	Membrane
HZS93_01360	COG2207	Transcriptional regulator
HZS93_01361	COG0326	Molecular chaperone. Has ATPase activity
HZS93_01363	COG1366	Belongs to the anti-sigma-factor antagonist family
HZS93_01364	COG1366	Belongs to the anti-sigma-factor antagonist family
HZS93_01365	COG2172	sigma factor antagonist activity
HZS93_01370	COG4771	TonB-dependent receptor
HZS93_01372	COG5507	3-demethylubiquinone-9 3-methyltransferase
HZS93_01373	COG2205	protein histidine kinase activity
HZS93_01375	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HZS93_01376	COG2205	protein histidine kinase activity
HZS93_01376	COG3437	response regulator, receiver
HZS93_01376	COG3850	Histidine kinase
HZS93_01376	COG4999	Histidine kinase
HZS93_01377	COG0784	Response regulator, receiver
HZS93_01377	COG4191	Histidine kinase
HZS93_01382	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZS93_01384	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HZS93_01387	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZS93_01388	COG0228	four-way junction DNA binding
HZS93_01389	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HZS93_01390	COG0336	Belongs to the RNA methyltransferase TrmD family
HZS93_01391	COG0335	large ribosomal subunit rRNA binding
HZS93_01392	COG0534	Mate efflux family protein
HZS93_01396	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HZS93_01398	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HZS93_01400	COG3209	COG3209 Rhs family protein
HZS93_01405	COG3250	beta-galactosidase activity
HZS93_01406	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HZS93_01410	COG1960	acyl-CoA dehydrogenase activity
HZS93_01411	COG1024	Enoyl-CoA hydratase
HZS93_01415	COG1024	Enoyl-CoA hydratase
HZS93_01415	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZS93_01418	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZS93_01419	COG0481	GTPase activity
HZS93_01422	COG0571	ribonuclease III activity
HZS93_01423	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HZS93_01424	COG1381	Involved in DNA repair and RecF pathway recombination
HZS93_01426	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZS93_01427	COG2954	triphosphatase activity
HZS93_01428	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HZS93_01429	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HZS93_01430	COG3046	protein related to deoxyribodipyrimidine photolyase
HZS93_01431	COG1472	Belongs to the glycosyl hydrolase 3 family
HZS93_01432	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HZS93_01433	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HZS93_01434	COG1278	Cold shock
HZS93_01435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZS93_01437	COG1201	RNA secondary structure unwinding
HZS93_01438	COG1793	dna ligase
HZS93_01440	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HZS93_01440	COG1793	dna ligase
HZS93_01446	COG0183	Belongs to the thiolase family
HZS93_01451	COG1451	nucleotide metabolic process
HZS93_01452	COG5487	UPF0391 membrane protein
HZS93_01454	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HZS93_01457	COG1077	Cell shape determining protein MreB Mrl
HZS93_01458	COG1047	Peptidyl-prolyl cis-trans
HZS93_01460	COG2824	Alkylphosphonate utilization operon protein PhnA
HZS93_01462	COG1902	pentaerythritol trinitrate reductase activity
HZS93_01463	COG2814	Major facilitator Superfamily
HZS93_01469	COG0392	lysyltransferase activity
HZS93_01469	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HZS93_01471	COG0251	oxidation-reduction process
HZS93_01472	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZS93_01475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZS93_01480	COG1595	DNA-templated transcription, initiation
HZS93_01484	COG2878	Part of a membrane complex involved in electron transport
HZS93_01486	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZS93_01486	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZS93_01489	COG1131	(ABC) transporter
HZS93_01490	COG0346	lactoylglutathione lyase activity
HZS93_01491	COG0833	amino acid
HZS93_01492	COG2040	homocysteine
HZS93_01494	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HZS93_01498	COG1695	Transcriptional regulator
HZS93_01502	COG1981	membrane
HZS93_01505	COG0825	malonyl-CoA metabolic process
HZS93_01507	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HZS93_01508	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZS93_01509	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZS93_01510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZS93_01511	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZS93_01514	COG0750	zinc metalloprotease
HZS93_01515	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HZS93_01516	COG0575	Belongs to the CDS family
HZS93_01517	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HZS93_01518	COG0233	cytoplasmic translational termination
HZS93_01519	COG0528	UMP kinase activity
HZS93_01521	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HZS93_01522	COG0052	Belongs to the universal ribosomal protein uS2 family
HZS93_01530	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HZS93_01532	COG1393	Belongs to the ArsC family
HZS93_01533	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZS93_01534	COG0367	asparagine synthase
HZS93_01536	COG4774	siderophore transport
HZS93_01539	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZS93_01547	COG1566	PFAM secretion protein HlyD family protein
HZS93_01548	COG2814	Major facilitator Superfamily
HZS93_01558	COG0339	signal peptide processing
HZS93_01560	COG0386	Belongs to the glutathione peroxidase family
HZS93_01571	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HZS93_01572	COG0084	hydrolase, TatD family'
HZS93_01575	COG1960	acyl-CoA dehydrogenase activity
HZS93_01579	COG0367	asparagine synthase
HZS93_01581	COG0305	Participates in initiation and elongation during chromosome replication
HZS93_01582	COG0415	Belongs to the DNA photolyase family
HZS93_01586	COG0583	DNA-binding transcription factor activity
HZS93_01595	COG3706	GGDEF domain
HZS93_01623	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HZS93_01626	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZS93_01628	COG0497	DNA recombination
HZS93_01629	COG1420	regulation of RNA biosynthetic process
HZS93_01630	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HZS93_01631	COG0443	Heat shock 70 kDa protein
HZS93_01632	COG0484	heat shock protein binding
HZS93_01634	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HZS93_01640	COG0583	DNA-binding transcription factor activity
HZS93_01641	COG1132	(ABC) transporter
HZS93_01648	COG2850	peptidyl-arginine hydroxylation
HZS93_01652	COG1253	flavin adenine dinucleotide binding
HZS93_01658	COG1131	(ABC) transporter
HZS93_01659	COG1725	Transcriptional regulator
HZS93_01661	COG0386	Belongs to the glutathione peroxidase family
HZS93_01664	COG2900	Belongs to the SlyX family
HZS93_01669	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZS93_01671	COG1410	methionine synthase
HZS93_01671	COG0646	methionine synthase
HZS93_01672	COG0646	methionine synthase
HZS93_01672	COG1410	methionine synthase
HZS93_01673	COG2226	methyltransferase
HZS93_01674	COG1960	acyl-CoA dehydrogenase activity
HZS93_01675	COG1960	acyl-CoA dehydrogenase activity
HZS93_01676	COG1960	acyl-CoA dehydrogenase activity
HZS93_01677	COG1960	acyl-CoA dehydrogenase activity
HZS93_01681	COG0557	exoribonuclease II activity
HZS93_01683	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZS93_01685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HZS93_01687	COG0704	Plays a role in the regulation of phosphate uptake
HZS93_01688	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZS93_01689	COG0581	inorganic phosphate transmembrane transporter activity
HZS93_01690	COG0573	inorganic phosphate transmembrane transporter activity
HZS93_01691	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HZS93_01696	COG0659	secondary active sulfate transmembrane transporter activity
HZS93_01697	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HZS93_01699	COG1024	Enoyl-CoA hydratase
HZS93_01701	COG0494	nUDIX hydrolase
HZS93_01708	COG0488	(ABC) transporter
HZS93_01710	COG0116	Belongs to the methyltransferase superfamily
HZS93_01710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HZS93_01711	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZS93_01716	COG2925	Exonuclease
HZS93_01718	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZS93_01719	COG3844	kynureninase activity
HZS93_01721	COG0662	Cupin 2, conserved barrel domain protein
HZS93_01722	COG0288	reversible hydration of carbon dioxide
HZS93_01735	COG2808	Putative FMN-binding domain
HZS93_01739	COG0017	Asparaginyl-tRNA synthetase
HZS93_01741	COG0316	Belongs to the HesB IscA family
HZS93_01742	COG0360	Binds together with S18 to 16S ribosomal RNA
HZS93_01743	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HZS93_01744	COG0359	binds to the 23S rRNA
HZS93_01746	COG3115	cell septum assembly
HZS93_01748	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZS93_01749	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HZS93_01750	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HZS93_01753	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HZS93_01757	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HZS93_01759	COG2986	histidine ammonia-lyase
HZS93_01760	COG1228	amidohydrolase
HZS93_01770	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HZS93_01771	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HZS93_01772	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HZS93_01773	COG1605	Chorismate mutase
HZS93_01773	COG0077	Prephenate dehydratase
HZS93_01774	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HZS93_01777	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HZS93_01778	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HZS93_01779	COG0583	DNA-binding transcription factor activity
HZS93_01793	COG0840	transmembrane signaling receptor activity
HZS93_01800	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HZS93_01801	COG4191	Histidine kinase
HZS93_01801	COG0784	Response regulator, receiver
HZS93_01804	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZS93_01806	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HZS93_01808	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZS93_01811	COG1595	DNA-templated transcription, initiation
HZS93_01822	COG2244	polysaccharide biosynthetic process
HZS93_01829	COG2264	protein methyltransferase activity
HZS93_01831	COG0438	transferase activity, transferring glycosyl groups
HZS93_01834	COG1136	(ABC) transporter
HZS93_01836	COG0477	Major facilitator Superfamily
HZS93_01837	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZS93_01840	COG1253	flavin adenine dinucleotide binding
HZS93_01843	COG0306	phosphate transporter
HZS93_01849	COG0504	CTP synthase activity
HZS93_01850	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HZS93_01852	COG0148	phosphopyruvate hydratase activity
HZS93_01853	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HZS93_01854	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HZS93_01855	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HZS93_01856	COG0585	pseudouridine synthase activity
HZS93_01857	COG2840	Smr protein MutS2
HZS93_01858	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HZS93_01859	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HZS93_01860	COG1238	metal cluster binding
HZS93_01863	COG1534	Rna-binding protein
HZS93_01864	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HZS93_01866	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HZS93_01867	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HZS93_01869	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HZS93_01870	COG1546	Belongs to the CinA family
HZS93_01872	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HZS93_01873	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HZS93_01875	COG2137	regulation of response to DNA damage stimulus
HZS93_01876	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HZS93_01877	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HZS93_01881	COG1741	Belongs to the pirin family
HZS93_01882	COG0583	DNA-binding transcription factor activity
HZS93_01887	COG0351	phosphomethylpyrimidine kinase
HZS93_01887	COG0352	thiamine-phosphate diphosphorylase activity
HZS93_01890	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HZS93_01891	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HZS93_01894	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZS93_01896	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HZS93_01897	COG3734	2-keto-3-deoxy-galactonokinase
HZS93_01899	COG4948	Mandelate Racemase Muconate Lactonizing
HZS93_01900	COG0800	Aldolase
HZS93_01908	COG1501	Belongs to the glycosyl hydrolase 31 family
HZS93_01910	COG1070	Carbohydrate kinase
HZS93_01911	COG2115	Belongs to the xylose isomerase family
HZS93_01912	COG0477	Major facilitator Superfamily
HZS93_01916	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZS93_01917	COG1469	GTP cyclohydrolase I activity
HZS93_01921	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HZS93_01922	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HZS93_01923	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HZS93_01924	COG0166	Belongs to the GPI family
HZS93_01929	COG1472	Belongs to the glycosyl hydrolase 3 family
HZS93_01932	COG2203	Gaf domain
HZS93_01932	COG3706	GGDEF domain
HZS93_01932	COG4251	negative regulation of phosphorylation
HZS93_01932	COG5001	Diguanylate cyclase
HZS93_01933	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZS93_01934	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HZS93_01936	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HZS93_01937	COG0671	phosphoesterase, PA-phosphatase related
HZS93_01940	COG1794	racemase activity, acting on amino acids and derivatives
HZS93_01942	COG0697	spore germination
HZS93_01943	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HZS93_01944	COG0167	dihydroorotate dehydrogenase activity
HZS93_01948	COG1012	belongs to the aldehyde dehydrogenase family
HZS93_01951	COG1215	transferase activity, transferring glycosyl groups
HZS93_01952	COG0726	polysaccharide deacetylase
HZS93_01952	COG1649	PFAM Uncharacterised BCR, COG1649
HZS93_01955	COG3210	domain, Protein
HZS93_01957	COG3210	domain, Protein
HZS93_01968	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZS93_01969	COG0124	histidyl-tRNA synthetase
HZS93_01971	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HZS93_01972	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HZS93_01973	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZS93_01974	COG0131	Imidazoleglycerol-phosphate dehydratase
HZS93_01974	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HZS93_01975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HZS93_01976	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HZS93_01977	COG0107	imidazoleglycerol-phosphate synthase activity
HZS93_01978	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HZS93_01978	COG0140	phosphoribosyl-ATP diphosphatase activity
HZS93_01981	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HZS93_01982	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HZS93_01983	COG0235	Class ii aldolase
HZS93_01984	COG0531	amino acid
HZS93_01985	COG0531	amino acid
HZS93_01987	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZS93_01988	COG0277	FAD linked oxidase domain protein
HZS93_01992	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HZS93_02001	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZS93_02002	COG2258	MOSC domain
HZS93_02003	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HZS93_02004	COG0505	Belongs to the CarA family
HZS93_02006	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HZS93_02007	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZS93_02009	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HZS93_02017	COG3279	Response regulator of the LytR AlgR family
HZS93_02018	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HZS93_02019	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HZS93_02021	COG0784	Response regulator, receiver
HZS93_02021	COG2198	Histidine kinase
HZS93_02021	COG2205	protein histidine kinase activity
HZS93_02022	COG1024	Enoyl-CoA hydratase
HZS93_02023	COG0318	PFAM AMP-dependent synthetase and ligase
HZS93_02029	COG2267	carboxylic ester hydrolase activity
HZS93_02031	COG2201	protein-glutamate methylesterase activity
HZS93_02032	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HZS93_02034	COG0840	transmembrane signaling receptor activity
HZS93_02036	COG0835	chemotaxis
HZS93_02039	COG0840	transmembrane signaling receptor activity
HZS93_02040	COG0840	transmembrane signaling receptor activity
HZS93_02041	COG0840	transmembrane signaling receptor activity
HZS93_02042	COG0840	transmembrane signaling receptor activity
HZS93_02043	COG0840	transmembrane signaling receptor activity
HZS93_02045	COG0840	transmembrane signaling receptor activity
HZS93_02046	COG0840	transmembrane signaling receptor activity
HZS93_02047	COG0840	transmembrane signaling receptor activity
HZS93_02048	COG0840	transmembrane signaling receptor activity
HZS93_02051	COG0840	transmembrane signaling receptor activity
HZS93_02054	COG0840	transmembrane signaling receptor activity
HZS93_02055	COG2198	Histidine kinase
HZS93_02055	COG0643	Histidine kinase
HZS93_02056	COG0745	RESPONSE REGULATOR receiver
HZS93_02058	COG0835	chemotaxis
HZS93_02060	COG1360	Flagellar Motor Protein
HZS93_02061	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HZS93_02079	COG2963	transposase activity
HZS93_02085	COG0641	radical SAM
HZS93_02089	COG0643	Histidine kinase
HZS93_02089	COG0784	Response regulator, receiver
HZS93_02089	COG2198	Histidine kinase
HZS93_02095	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZS93_02101	COG1684	flagellar biosynthetic protein fliR
HZS93_02105	COG3190	flagellar
HZS93_02115	COG1677	Flagellar hook-basal body complex protein FliE
HZS93_02121	COG1028	Short-chain dehydrogenase reductase Sdr
HZS93_02122	COG1028	Short-chain dehydrogenase reductase Sdr
HZS93_02123	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZS93_02127	COG2201	protein-glutamate methylesterase activity
HZS93_02133	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HZS93_02135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZS93_02136	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZS93_02138	COG1705	Flagellar rod assembly protein muramidase FlgJ
HZS93_02138	COG3951	Flagellar rod assembly protein muramidase FlgJ
HZS93_02139	COG1706	bacterial-type flagellum-dependent cell motility
HZS93_02140	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HZS93_02142	COG4787	bacterial-type flagellum-dependent cell motility
HZS93_02144	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HZS93_02145	COG1558	bacterial-type flagellum-dependent cell motility
HZS93_02147	COG0784	Response regulator, receiver
HZS93_02147	COG0835	chemotaxis
HZS93_02151	COG5002	protein histidine kinase activity
HZS93_02157	COG2915	High frequency lysogenization protein hflD homolog
HZS93_02158	COG0482	sulfurtransferase activity
HZS93_02161	COG0542	response to heat
HZS93_02163	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HZS93_02165	COG0492	ferredoxin-NADP+ reductase activity
HZS93_02166	COG1674	ftsk spoiiie
HZS93_02168	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HZS93_02170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HZS93_02171	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HZS93_02173	COG0183	Belongs to the thiolase family
HZS93_02174	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZS93_02174	COG1024	Enoyl-CoA hydratase
HZS93_02177	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HZS93_02179	COG1426	Protein conserved in bacteria
HZS93_02181	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZS93_02182	COG1160	GTP binding
HZS93_02183	COG0303	'Molybdopterin
HZS93_02184	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HZS93_02192	COG0708	Exodeoxyribonuclease III
HZS93_02194	COG0303	'Molybdopterin
HZS93_02195	COG0746	molybdenum cofactor guanylyltransferase activity
HZS93_02198	COG1914	H( )-stimulated, divalent metal cation uptake system
HZS93_02201	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HZS93_02202	COG0668	transmembrane transport
HZS93_02204	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HZS93_02207	COG1028	Short-chain dehydrogenase reductase Sdr
HZS93_02208	COG1183	phosphatidylcholine synthase activity
HZS93_02210	COG3243	poly(R)-hydroxyalkanoic acid synthase
HZS93_02213	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZS93_02213	COG0723	plastoquinol--plastocyanin reductase activity
HZS93_02215	COG2183	response to ionizing radiation
HZS93_02216	COG0784	Response regulator, receiver
HZS93_02216	COG2205	protein histidine kinase activity
HZS93_02231	COG0800	Aldolase
HZS93_02232	COG0129	dihydroxy-acid dehydratase activity
HZS93_02233	COG0363	glucosamine-6-phosphate deaminase activity
HZS93_02234	COG0837	glucose binding
HZS93_02235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HZS93_02240	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HZS93_02243	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HZS93_02244	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HZS93_02246	COG4591	ABC-type transport system involved in lipoprotein release permease component
HZS93_02247	COG1136	(ABC) transporter
HZS93_02250	COG0811	peptide transport
HZS93_02252	COG1132	(ABC) transporter
HZS93_02253	COG1663	tetraacyldisaccharide 4'-kinase activity
HZS93_02254	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HZS93_02255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZS93_02257	COG0322	excinuclease ABC activity
HZS93_02258	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZS93_02267	COG2963	transposase activity
HZS93_02268	COG0582	viral genome integration into host DNA
HZS93_02270	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HZS93_02274	COG1054	Belongs to the UPF0176 family
HZS93_02276	COG1530	ribonuclease E activity
HZS93_02278	COG3064	Membrane
HZS93_02279	COG0428	transporter
HZS93_02281	COG2154	pterin-4-alpha-carbinolamine dehydratase
HZS93_02282	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HZS93_02282	COG0316	Belongs to the HesB IscA family
HZS93_02293	COG1028	Short-chain dehydrogenase reductase Sdr
HZS93_02312	COG1238	metal cluster binding
HZS93_02319	COG3279	Response regulator of the LytR AlgR family
HZS93_02328	COG4566	intracellular signal transduction
HZS93_02330	COG5001	Diguanylate cyclase
HZS93_02334	COG3685	Protein conserved in bacteria
HZS93_02339	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HZS93_02339	COG1648	precorrin-2 dehydrogenase activity
HZS93_02342	COG2814	Major facilitator Superfamily
HZS93_02345	COG1335	isochorismatase
HZS93_02348	COG2197	response regulator
HZS93_02352	COG0583	DNA-binding transcription factor activity
HZS93_02353	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HZS93_02354	COG3002	Belongs to the UPF0753 family
HZS93_02356	COG1396	sequence-specific DNA binding
HZS93_02357	COG5489	Protein of unknown function (DUF736)
HZS93_02359	COG2003	Belongs to the UPF0758 family
HZS93_02365	COG0582	viral genome integration into host DNA
HZS93_02368	COG4774	siderophore transport
HZS93_02372	COG2336	PFAM SpoVT AbrB
HZS93_02377	COG4206	TonB-dependent receptor
HZS93_02381	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HZS93_02381	COG2273	Hydrolase Family 16
HZS93_02385	COG2274	protein secretion by the type I secretion system
HZS93_02396	COG0270	DNA (cytosine-5-)-methyltransferase activity
HZS93_02406	COG4804	nuclease activity
HZS93_02409	COG5006	permease, DMT superfamily
HZS93_02412	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZS93_02414	COG3938	Belongs to the proline racemase family
HZS93_02417	COG2807	transmembrane transport
HZS93_02418	COG2207	Transcriptional regulator
HZS93_02447	COG0210	DNA helicase
HZS93_02462	COG2084	Dehydrogenase
HZS93_02466	COG2003	Belongs to the UPF0758 family
HZS93_02473	COG0582	viral genome integration into host DNA
HZS93_02475	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HZS93_02475	COG0519	Catalyzes the synthesis of GMP from XMP
HZS93_02477	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HZS93_02479	COG0475	glutathione-regulated potassium exporter activity
HZS93_02479	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZS93_02481	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HZS93_02483	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZS93_02484	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HZS93_02486	COG0776	regulation of translation
HZS93_02487	COG0539	negative regulation of cytoplasmic translation
HZS93_02488	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HZS93_02492	COG2957	Belongs to the agmatine deiminase family
HZS93_02493	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZS93_02498	COG0395	ABC-type sugar transport system, permease component
HZS93_02499	COG1175	transmembrane transport
HZS93_02505	COG2350	Protein conserved in bacteria
HZS93_02506	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HZS93_02507	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HZS93_02508	COG1187	pseudouridine synthase activity
HZS93_02512	COG0436	Aminotransferase
HZS93_02513	COG4133	protoheme IX ABC transporter activity
HZS93_02517	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HZS93_02518	COG1138	Cytochrome C-type biogenesis protein
HZS93_02522	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZS93_02523	COG1278	Cold shock
HZS93_02524	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HZS93_02525	COG4988	ABC transporter
HZS93_02527	COG1294	oxidase, subunit
HZS93_02533	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HZS93_02534	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HZS93_02536	COG0165	Argininosuccinate lyase
HZS93_02537	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HZS93_02539	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HZS93_02540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZS93_02542	COG0137	argininosuccinate synthase activity
HZS93_02543	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZS93_02545	COG0215	cysteine-tRNA ligase activity
HZS93_02546	COG2166	iron-sulfur cluster assembly
HZS93_02549	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HZS93_02550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZS93_02556	COG4302	ethanolamine ammonia-lyase activity
HZS93_02569	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZS93_02570	COG0402	S-adenosylhomocysteine deaminase activity
HZS93_02572	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HZS93_02573	COG1509	lysine 2,3-aminomutase activity
HZS93_02574	COG5001	Diguanylate cyclase
HZS93_02574	COG3300	MHYT domain
HZS93_02577	COG0483	inositol monophosphate 1-phosphatase activity
HZS93_02578	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HZS93_02582	COG0488	(ABC) transporter
HZS93_02583	COG0513	Belongs to the DEAD box helicase family
HZS93_02584	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZS93_02585	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HZS93_02587	COG0625	glutathione transferase activity
HZS93_02589	COG4681	YaeQ
HZS93_02590	COG2081	HI0933 family
HZS93_02592	COG0501	Belongs to the peptidase M48B family
HZS93_02593	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZS93_02594	COG1028	Short-chain dehydrogenase reductase Sdr
HZS93_02599	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HZS93_02600	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZS93_02601	COG0802	atpase or kinase
HZS93_02602	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HZS93_02602	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HZS93_02603	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HZS93_02604	COG1570	exodeoxyribonuclease VII activity
HZS93_02606	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HZS93_02643	COG0835	chemotaxis
HZS93_02644	COG0840	transmembrane signaling receptor activity
HZS93_02645	COG2094	Belongs to the DNA glycosylase MPG family
HZS93_02646	COG1201	RNA secondary structure unwinding
HZS93_02650	COG2969	positive regulation of protein catabolic process
HZS93_02651	COG0625	glutathione transferase activity
HZS93_02652	COG2857	Cytochrome c1
HZS93_02653	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HZS93_02654	COG0723	plastoquinol--plastocyanin reductase activity
HZS93_02656	COG0741	lytic transglycosylase activity
HZS93_02659	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZS93_02661	COG1702	phosphate starvation-inducible protein PhoH
HZS93_02663	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HZS93_02665	COG4535	Mg2 and Co2 transporter CorC
HZS93_02668	COG1012	belongs to the aldehyde dehydrogenase family
HZS93_02669	COG1177	transmembrane transport
HZS93_02670	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZS93_02671	COG3842	ATPase activity
HZS93_02675	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HZS93_02678	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HZS93_02679	COG0174	glutamine synthetase
HZS93_02680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZS93_02682	COG2703	oxygen carrier activity
HZS93_02683	COG0477	Major facilitator Superfamily
HZS93_02685	COG0243	molybdopterin cofactor binding
HZS93_02686	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HZS93_02687	COG2223	nitrite transmembrane transporter activity
HZS93_02690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZS93_02692	COG2733	membrane
HZS93_02693	COG5002	protein histidine kinase activity
HZS93_02693	COG2205	protein histidine kinase activity
HZS93_02693	COG0784	Response regulator, receiver
HZS93_02695	COG0477	Major facilitator Superfamily
HZS93_02697	COG2902	Dehydrogenase
HZS93_02699	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS93_02700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZS93_02701	COG1609	Transcriptional regulator
HZS93_02702	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZS93_02702	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZS93_02703	COG1105	Belongs to the carbohydrate kinase PfkB family
HZS93_02704	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZS93_02704	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZS93_02713	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZS93_02715	COG1862	Preprotein translocase
HZS93_02716	COG0343	queuine tRNA-ribosyltransferase activity
HZS93_02717	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HZS93_02725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HZS93_02726	COG3291	Pkd domain containing protein
HZS93_02727	COG0405	Gamma-glutamyltransferase
HZS93_02728	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZS93_02731	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HZS93_02732	COG0742	ribosomal rna small subunit methyltransferase
HZS93_02733	COG0326	Molecular chaperone. Has ATPase activity
HZS93_02751	COG0531	amino acid
HZS93_02754	COG0006	proline dipeptidase activity
HZS93_02756	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZS93_02759	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZS93_02760	COG3938	Belongs to the proline racemase family
HZS93_02762	COG0552	protein localization to endoplasmic reticulum
HZS93_02764	COG1194	a g-specific adenine glycosylase
HZS93_02765	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HZS93_02766	COG4191	Histidine kinase
HZS93_02766	COG0784	Response regulator, receiver
HZS93_02769	COG0322	excinuclease ABC activity
HZS93_02772	COG3040	lipid binding
HZS93_02775	COG1960	acyl-CoA dehydrogenase activity
HZS93_02777	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZS93_02781	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZS93_02782	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZS93_02783	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZS93_02788	COG0438	transferase activity, transferring glycosyl groups
HZS93_02790	COG0438	transferase activity, transferring glycosyl groups
HZS93_02791	COG0438	transferase activity, transferring glycosyl groups
HZS93_02801	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZS93_02801	COG0072	phenylalanine-tRNA ligase activity
HZS93_02802	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HZS93_02805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HZS93_02806	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZS93_02811	COG1082	Xylose isomerase domain protein TIM barrel
HZS93_02814	COG0366	Alpha amylase catalytic
HZS93_02818	COG0366	Alpha amylase catalytic
HZS93_02819	COG2801	Transposase and inactivated derivatives
HZS93_02830	COG3702	type iv secretory pathway
HZS93_02834	COG2948	multi-organism process
HZS93_02838	COG3505	Type IV secretory pathway VirD4
HZS93_02841	COG0556	nucleotide-excision repair
HZS93_02859	COG4695	Portal protein
HZS93_02868	COG3179	chitinase
HZS93_02880	COG2963	transposase activity
HZS93_02887	COG3275	phosphorelay sensor kinase activity
HZS93_02888	COG1611	Belongs to the LOG family
HZS93_02891	COG2095	MarC family integral membrane protein
HZS93_02893	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HZS93_02900	COG1185	polyribonucleotide nucleotidyltransferase activity
HZS93_02901	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HZS93_02902	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HZS93_02903	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HZS93_02904	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HZS93_02905	COG0195	Participates in both transcription termination and antitermination
HZS93_02906	COG0779	Required for maturation of 30S ribosomal subunits
HZS93_02908	COG1007	ATP synthesis coupled electron transport
HZS93_02913	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZS93_02914	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HZS93_02916	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HZS93_02917	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HZS93_02918	COG0649	NAD binding
HZS93_02919	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZS93_02920	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZS93_02921	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZS93_02924	COG0149	triose-phosphate isomerase activity
HZS93_02925	COG0300	oxidoreductase activity
HZS93_02931	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZS93_02932	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HZS93_02933	COG0159	tryptophan synthase activity
HZS93_02935	COG0133	tryptophan synthase activity
HZS93_02937	COG0135	phosphoribosylanthranilate isomerase activity
HZS93_02938	COG0101	tRNA pseudouridine synthase activity
HZS93_02942	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HZS93_02943	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZS93_02944	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HZS93_02945	COG2890	protein-(glutamine-N5) methyltransferase activity
HZS93_02947	COG0688	phosphatidylethanolamine metabolic process
HZS93_02950	COG0433	COG0433 Predicted ATPase
HZS93_02951	COG0494	nUDIX hydrolase
HZS93_02955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZS93_02956	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZS93_02961	COG0717	Belongs to the dCTP deaminase family
HZS93_02963	COG0489	protein tyrosine kinase activity
HZS93_02967	COG3590	peptidase
HZS93_02969	COG3590	peptidase
HZS93_02973	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZS93_02974	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZS93_02975	COG2311	Membrane
HZS93_02976	COG1047	Peptidyl-prolyl cis-trans
HZS93_02977	COG0791	NLP P60 protein
HZS93_02978	COG0791	NLP P60 protein
HZS93_02980	COG4106	trans-aconitate 2-methyltransferase activity
HZS93_02981	COG1301	dicarboxylic acid transport
HZS93_02982	COG1785	Belongs to the alkaline phosphatase family
HZS93_02984	COG0037	tRNA processing
HZS93_02985	COG1722	exodeoxyribonuclease VII activity
HZS93_02986	COG0142	geranyltranstransferase activity
HZS93_02987	COG4104	PAAR repeat-containing protein
HZS93_02989	COG0312	modulator of DNA gyrase
HZS93_02990	COG3028	Belongs to the UPF0307 family
HZS93_02991	COG0312	modulator of DNA gyrase
HZS93_02993	COG3164	Protein of unknown function
HZS93_02995	COG0424	maF-like protein
HZS93_02996	COG2968	Membrane
HZS93_02999	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HZS93_03002	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HZS93_03005	COG0495	leucyl-tRNA aminoacylation
HZS93_03007	COG3118	belongs to the thioredoxin family
HZS93_03012	COG2155	Conserved Protein
HZS93_03021	COG1132	(ABC) transporter
HZS93_03027	COG1538	Outer membrane efflux protein
HZS93_03028	COG0745	RESPONSE REGULATOR receiver
HZS93_03029	COG5002	protein histidine kinase activity
HZS93_03029	COG5000	phosphorelay sensor kinase activity
HZS93_03030	COG0475	glutathione-regulated potassium exporter activity
HZS93_03032	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HZS93_03037	COG1187	pseudouridine synthase activity
HZS93_03038	COG5001	Diguanylate cyclase
HZS93_03038	COG5002	protein histidine kinase activity
HZS93_03062	COG0667	Aldo Keto reductase
HZS93_03064	COG2814	Major facilitator Superfamily
HZS93_03065	COG0583	DNA-binding transcription factor activity
HZS93_03067	COG2207	Transcriptional regulator
HZS93_03069	COG1309	transcriptional regulator
HZS93_03074	COG0735	belongs to the Fur family
HZS93_03075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZS93_03080	COG4452	Inner membrane protein CreD
HZS93_03083	COG2205	protein histidine kinase activity
HZS93_03084	COG0745	RESPONSE REGULATOR receiver
HZS93_03085	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HZS93_03087	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HZS93_03094	COG0643	Histidine kinase
HZS93_03094	COG2198	Histidine kinase
HZS93_03096	COG0840	transmembrane signaling receptor activity
HZS93_03097	COG0835	chemotaxis
HZS93_03098	COG2199	diguanylate cyclase activity
HZS93_03098	COG2200	EAL domain
HZS93_03098	COG2202	Pas domain
HZS93_03099	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HZS93_03100	COG2201	protein-glutamate methylesterase activity
HZS93_03101	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZS93_03102	COG3590	peptidase
HZS93_03104	COG0588	phosphoglycerate mutase activity
HZS93_03105	COG1515	deoxyribonuclease V activity
HZS93_03107	COG1741	Belongs to the pirin family
HZS93_03110	COG1741	Belongs to the pirin family
HZS93_03111	COG1966	Carbon starvation protein
HZS93_03112	COG2879	small protein
HZS93_03125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZS93_03126	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HZS93_03127	COG2080	2 iron, 2 sulfur cluster binding
HZS93_03130	COG5001	Diguanylate cyclase
HZS93_03130	COG4251	negative regulation of phosphorylation
HZS93_03130	COG3706	GGDEF domain
HZS93_03130	COG2203	Gaf domain
HZS93_03138	COG0629	single-stranded DNA binding
HZS93_03139	COG0142	geranyltranstransferase activity
HZS93_03142	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HZS93_03145	COG0527	aspartate kinase activity
HZS93_03146	COG0384	phenazine biosynthesis protein PhzF
HZS93_03147	COG0384	phenazine biosynthesis protein PhzF
HZS93_03149	COG1764	response to oxidative stress
HZS93_03150	COG0540	Belongs to the ATCase OTCase family
HZS93_03151	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HZS93_03152	COG1678	Uncharacterized ACR, COG1678
HZS93_03154	COG0519	Catalyzes the synthesis of GMP from XMP
HZS93_03156	COG5297	Belongs to the glycosyl hydrolase family 6
HZS93_03159	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HZS93_03162	COG0739	heme binding
HZS93_03166	COG0693	protein deglycase activity
HZS93_03168	COG1959	2 iron, 2 sulfur cluster binding
HZS93_03169	COG0719	Fe-S assembly protein
HZS93_03170	COG0396	ATPase activity
HZS93_03171	COG0719	Fe-S assembly protein
HZS93_03172	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZS93_03174	COG2146	nitrite reductase [NAD(P)H] activity
HZS93_03175	COG4774	siderophore transport
HZS93_03176	COG3128	pkhd-type hydroxylase
HZS93_03181	COG1477	protein flavinylation
HZS93_03182	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HZS93_03185	COG1555	photosystem II stabilization
HZS93_03186	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZS93_03188	COG3178	'Phosphotransferase
HZS93_03189	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HZS93_03191	COG0628	permease
HZS93_03193	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HZS93_03195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HZS93_03199	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HZS93_03200	COG0271	Belongs to the BolA IbaG family
HZS93_03202	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HZS93_03204	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HZS93_03205	COG1137	ATPase activity
HZS93_03208	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZS93_03209	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HZS93_03210	COG1660	Displays ATPase and GTPase activities
HZS93_03212	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZS93_03213	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZS93_03215	COG2239	Acts as a magnesium transporter
HZS93_03218	COG1294	oxidase, subunit
HZS93_03219	COG1271	oxidase subunit
HZS93_03221	COG1113	amino acid transport
HZS93_03227	COG2197	response regulator
HZS93_03228	COG0531	amino acid
HZS93_03235	COG1234	tRNA 3'-trailer cleavage
HZS93_03244	COG2814	Major facilitator Superfamily
HZS93_03246	COG0754	glutathionylspermidine amidase activity
HZS93_03251	COG1842	Phage shock protein A
HZS93_03253	COG0259	pyridoxamine-phosphate oxidase activity
HZS93_03254	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HZS93_03255	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HZS93_03257	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HZS93_03272	COG2814	Major facilitator Superfamily
HZS93_03275	COG2205	protein histidine kinase activity
HZS93_03275	COG0784	Response regulator, receiver
HZS93_03275	COG2198	Histidine kinase
HZS93_03276	COG2205	protein histidine kinase activity
HZS93_03276	COG2198	Histidine kinase
HZS93_03276	COG0784	Response regulator, receiver
HZS93_03277	COG2353	YceI-like domain
HZS93_03281	COG1760	l-serine dehydratase
HZS93_03284	COG0460	homoserine dehydrogenase
HZS93_03284	COG0527	aspartate kinase activity
HZS93_03285	COG0626	cystathionine gamma-synthase activity
HZS93_03286	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZS93_03287	COG0739	heme binding
HZS93_03288	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HZS93_03289	COG1272	protein, Hemolysin III
HZS93_03290	COG2982	Protein involved in outer membrane biogenesis
HZS93_03291	COG0516	GMP reductase activity
HZS93_03291	COG0517	IMP dehydrogenase activity
HZS93_03292	COG0463	Glycosyl transferase, family 2
HZS93_03293	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZS93_03294	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HZS93_03296	COG4771	TonB-dependent receptor
HZS93_03298	COG1309	transcriptional regulator
HZS93_03300	COG1960	acyl-CoA dehydrogenase activity
HZS93_03306	COG0509	glycine decarboxylation via glycine cleavage system
HZS93_03307	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HZS93_03309	COG0330	HflC and HflK could
HZS93_03310	COG1742	UPF0060 membrane protein
HZS93_03311	COG3956	TIGRFAM MazG family protein
HZS93_03313	COG0494	nUDIX hydrolase
HZS93_03315	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HZS93_03316	COG0837	glucose binding
HZS93_03319	COG1388	LysM domain
HZS93_03319	COG3858	chitin binding
HZS93_03320	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HZS93_03322	COG1472	Belongs to the glycosyl hydrolase 3 family
HZS93_03325	COG0531	amino acid
HZS93_03327	COG1486	melibiose metabolic process
HZS93_03329	COG3537	Alpha-1,2-mannosidase
HZS93_03337	COG3142	Participates in the control of copper homeostasis
HZS93_03338	COG1446	asparaginase
HZS93_03344	COG0784	Response regulator, receiver
HZS93_03344	COG2198	Histidine kinase
HZS93_03344	COG0643	Histidine kinase
HZS93_03345	COG0840	transmembrane signaling receptor activity
HZS93_03346	COG0835	chemotaxis
HZS93_03349	COG0189	ligase activity
HZS93_03351	COG1397	ADP-ribosylglycohydrolase
HZS93_03353	COG1199	ATP-dependent helicase activity
HZS93_03355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZS93_03356	COG1215	transferase activity, transferring glycosyl groups
HZS93_03361	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZS93_03363	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HZS93_03364	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HZS93_03365	COG0535	radical SAM domain protein
HZS93_03366	COG0535	radical SAM domain protein
HZS93_03370	COG0837	glucose binding
HZS93_03373	COG1643	Atp-dependent helicase
HZS93_03374	COG0783	Belongs to the Dps family
HZS93_03376	COG0514	ATP-dependent DNA helicase (RecQ)
HZS93_03383	COG0840	transmembrane signaling receptor activity
HZS93_03387	COG3920	Histidine kinase
HZS93_03388	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HZS93_03390	COG0602	queuosine metabolic process
HZS93_03392	COG2885	chlorophyll binding
HZS93_03393	COG0823	Involved in the tonB-independent uptake of proteins
HZS93_03395	COG0848	biopolymer transport protein
HZS93_03397	COG0824	Thioesterase
HZS93_03398	COG2255	four-way junction helicase activity
HZS93_03400	COG3158	transport of potassium into the cell
HZS93_03401	COG0632	four-way junction helicase activity
HZS93_03402	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HZS93_03403	COG0217	transcriptional regulatory protein
HZS93_03406	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HZS93_03409	COG0477	Major facilitator Superfamily
HZS93_03418	COG0488	(ABC) transporter
HZS93_03426	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZS93_03426	COG4651	solute:proton antiporter activity
HZS93_03431	COG4772	TonB-dependent receptor
HZS93_03433	COG4264	IucA IucC family
HZS93_03436	COG0019	diaminopimelate decarboxylase activity
HZS93_03441	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HZS93_03443	COG1492	cobalamin metabolic process
HZS93_03445	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HZS93_03449	COG4206	TonB-dependent receptor
HZS93_03450	COG0542	response to heat
HZS93_03451	COG1116	anion transmembrane transporter activity
HZS93_03452	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZS93_03453	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZS93_03454	COG0667	Aldo Keto reductase
HZS93_03455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZS93_03456	COG4771	TonB-dependent receptor
HZS93_03457	COG2827	Endonuclease containing a URI domain
HZS93_03466	COG1877	trehalose-phosphatase activity
HZS93_03467	COG3387	PFAM Glycoside hydrolase 15-related
HZS93_03471	COG0840	transmembrane signaling receptor activity
HZS93_03472	COG3011	Protein conserved in bacteria
HZS93_03475	COG0564	pseudouridine synthase activity
HZS93_03476	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZS93_03478	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZS93_03478	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HZS93_03483	COG2951	lytic endotransglycosylase activity
HZS93_03484	COG4644	lycopene metabolic process
HZS93_03490	COG2369	cell adhesion
HZS93_03495	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HZS93_03496	COG0045	succinate-CoA ligase (ADP-forming) activity
HZS93_03500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZS93_03507	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HZS93_03508	COG0237	dephospho-CoA kinase activity
HZS93_03514	COG5002	protein histidine kinase activity
HZS93_03515	COG0745	RESPONSE REGULATOR receiver
HZS93_03517	COG0189	ligase activity
HZS93_03533	COG2003	Belongs to the UPF0758 family
HZS93_03538	COG0784	Response regulator, receiver
HZS93_03538	COG4191	Histidine kinase
HZS93_03539	COG4191	Histidine kinase
HZS93_03539	COG0784	Response regulator, receiver
HZS93_03564	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HZS93_03570	COG2022	thiamine diphosphate biosynthetic process
HZS93_03571	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HZS93_03572	COG3273	potassium ion transport
HZS93_03572	COG0471	metal ion transport
HZS93_03577	COG1970	mechanosensitive ion channel activity
HZS93_03581	COG3250	beta-galactosidase activity
HZS93_03582	COG4948	Mandelate Racemase Muconate Lactonizing
HZS93_03585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZS93_03587	COG0308	aminopeptidase N
HZS93_03595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZS93_03597	COG2895	sulfate adenylyltransferase (ATP) activity
HZS93_03597	COG0529	Catalyzes the synthesis of activated sulfate
HZS93_03598	COG0175	sulfate reduction
HZS93_03599	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HZS93_03600	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZS93_03601	COG0175	sulfate reduction
HZS93_03605	COG2198	Histidine kinase
HZS93_03605	COG0784	Response regulator, receiver
HZS93_03605	COG2205	protein histidine kinase activity
HZS93_03609	COG1648	precorrin-2 dehydrogenase activity
HZS93_03609	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HZS93_03612	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HZS93_03613	COG3588	fructose-bisphosphate aldolase
HZS93_03616	COG0469	pyruvate kinase activity
HZS93_03618	COG0126	phosphoglycerate kinase activity
HZS93_03623	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HZS93_03625	COG3047	cAMP biosynthetic process
HZS93_03626	COG3047	cAMP biosynthetic process
HZS93_03628	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZS93_03628	COG3453	Protein conserved in bacteria
HZS93_03629	COG0725	ABC transporter, periplasmic molybdate-binding protein
HZS93_03630	COG4149	molybdate abc transporter
HZS93_03631	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HZS93_03638	COG1376	ErfK ybiS ycfS ynhG family protein
HZS93_03639	COG0739	heme binding
HZS93_03641	COG4773	Receptor
HZS93_03642	COG0596	Alpha beta hydrolase
HZS93_03643	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HZS93_03644	COG1301	dicarboxylic acid transport
HZS93_03646	COG2304	oxidoreductase activity
HZS93_03650	COG0714	Associated with various cellular activities
HZS93_03657	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HZS93_03662	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HZS93_03664	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZS93_03666	COG0194	GDP metabolic process
HZS93_03667	COG1561	YicC-like family, N-terminal region
HZS93_03668	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HZS93_03670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HZS93_03671	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZS93_03674	COG0006	proline dipeptidase activity
HZS93_03676	COG0006	proline dipeptidase activity
HZS93_03677	COG3079	Belongs to the UPF0149 family
HZS93_03681	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HZS93_03683	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HZS93_03685	COG2912	Transglutaminase-like superfamily
HZS93_03686	COG1773	rubredoxin
HZS93_03687	COG0352	thiamine-phosphate diphosphorylase activity
HZS93_03689	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZS93_03692	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZS93_03698	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZS93_03699	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZS93_03701	COG1028	Short-chain dehydrogenase reductase Sdr
HZS93_03703	COG0671	phosphoesterase, PA-phosphatase related
HZS93_03704	COG3781	membrane
HZS93_03706	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZS93_03707	COG0563	adenylate kinase activity
HZS93_03710	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HZS93_03712	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HZS93_03716	COG3710	Transcriptional regulator
HZS93_03717	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HZS93_03720	COG0840	transmembrane signaling receptor activity
HZS93_03721	COG0405	Gamma-glutamyltransferase
HZS93_03722	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HZS93_03726	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZS93_03727	COG0473	3-isopropylmalate dehydrogenase activity
HZS93_03728	COG0066	3-isopropylmalate dehydratase activity
HZS93_03729	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HZS93_03733	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HZS93_03734	COG1538	Outer membrane efflux protein
HZS93_03735	COG1519	Transferase
HZS93_03736	COG1560	Kdo2-lipid A biosynthetic process
HZS93_03741	COG0280	phosphate acetyltransferase
HZS93_03741	COG0281	malic enzyme
HZS93_03742	COG1301	dicarboxylic acid transport
HZS93_03747	COG0583	DNA-binding transcription factor activity
HZS93_03748	COG0667	Aldo Keto reductase
HZS93_03751	COG2197	response regulator
HZS93_03753	COG0642	Histidine kinase
HZS93_03757	COG2851	Citrate transporter
HZS93_03758	COG1028	Short-chain dehydrogenase reductase Sdr
HZS93_03759	COG1609	Transcriptional regulator
HZS93_03761	COG2211	Major facilitator Superfamily
HZS93_03766	COG1162	GTPase activity
HZS93_03772	COG4773	Receptor
HZS93_03773	COG0726	polysaccharide deacetylase
HZS93_03774	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HZS93_03777	COG2801	Transposase and inactivated derivatives
HZS93_03781	COG1307	EDD domain protein, DegV family
HZS93_03782	COG0242	peptide deformylase activity
HZS93_03788	COG0457	Tetratricopeptide repeat
HZS93_03789	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HZS93_03790	COG1215	transferase activity, transferring glycosyl groups
HZS93_03791	COG1215	transferase activity, transferring glycosyl groups
HZS93_03794	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HZS93_03805	COG2188	Transcriptional regulator
HZS93_03808	COG1450	Type ii and iii secretion system protein
HZS93_03811	COG3166	PFAM Fimbrial assembly family protein
HZS93_03812	COG3156	type II secretion system protein K
HZS93_03813	COG4795	General secretion pathway protein
HZS93_03814	COG2165	general secretion pathway protein
HZS93_03815	COG4970	Tfp pilus assembly protein FimT
HZS93_03816	COG2165	general secretion pathway protein
HZS93_03817	COG1459	type II secretion system
HZS93_03819	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZS93_03820	COG1404	Belongs to the peptidase S8 family
HZS93_03821	COG5295	Hep Hag repeat protein
HZS93_03822	COG1404	Belongs to the peptidase S8 family
HZS93_03823	COG5295	Hep Hag repeat protein
HZS93_03825	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZS93_03825	COG0047	phosphoribosylformylglycinamidine synthase activity
HZS93_03827	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HZS93_03829	COG4974	Belongs to the 'phage' integrase family
HZS93_03832	COG0795	lipopolysaccharide-transporting ATPase activity
HZS93_03834	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HZS93_03837	COG0525	valine-tRNA ligase activity
HZS93_03843	COG1183	phosphatidylcholine synthase activity
HZS93_03845	COG0442	prolyl-tRNA aminoacylation
HZS93_03848	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HZS93_03849	COG1127	ABC transporter
HZS93_03850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HZS93_03850	COG3218	ABC-type transport auxiliary lipoprotein component
HZS93_03857	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZS93_03858	COG0662	Cupin 2, conserved barrel domain protein
HZS93_03858	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HZS93_03865	COG2086	electron transfer activity
HZS93_03868	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HZS93_03868	COG0546	phosphoglycolate phosphatase activity
HZS93_03869	COG0277	FAD linked oxidase domain protein
HZS93_03872	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZS93_03878	COG1216	Glycosyl transferase, family 2
HZS93_03878	COG0438	transferase activity, transferring glycosyl groups
HZS93_03882	COG0626	cystathionine gamma-synthase activity
HZS93_03888	COG0625	glutathione transferase activity
HZS93_03891	COG0513	Belongs to the DEAD box helicase family
HZS93_03893	COG4206	TonB-dependent receptor
HZS93_03895	COG0720	synthase
HZS93_03897	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HZS93_03899	COG1956	GAF domain-containing protein
HZS93_03901	COG2819	hydrolase of the alpha beta superfamily
HZS93_03904	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZS93_03905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZS93_03908	COG0339	signal peptide processing
HZS93_03919	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZS93_03920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS93_03921	COG1136	(ABC) transporter
HZS93_03921	COG4591	ABC-type transport system involved in lipoprotein release permease component
HZS93_03922	COG1136	(ABC) transporter
HZS93_03922	COG0577	efflux transmembrane transporter activity
HZS93_03923	COG0577	efflux transmembrane transporter activity
HZS93_03927	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HZS93_03930	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HZS93_03931	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HZS93_03932	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HZS93_03933	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HZS93_03934	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZS93_03935	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HZS93_03937	COG0356	it plays a direct role in the translocation of protons across the membrane
HZS93_03941	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZS93_03943	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZS93_03951	COG2011	ABC-type metal ion transport system permease component
HZS93_03952	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HZS93_03953	COG0697	spore germination
HZS93_03954	COG1666	GTP binding
HZS93_03956	COG0784	Response regulator, receiver
HZS93_03956	COG2198	Histidine kinase
HZS93_03956	COG5002	protein histidine kinase activity
HZS93_03961	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZS93_03962	COG1187	pseudouridine synthase activity
HZS93_03963	COG2813	Specifically methylates the guanine in position
HZS93_03967	COG2202	Pas domain
HZS93_03967	COG2205	protein histidine kinase activity
HZS93_03971	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HZS93_03972	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZS93_03984	COG0842	Transport permease protein
HZS93_03985	COG1131	(ABC) transporter
HZS93_03986	COG0025	NhaP-type Na H and K H
HZS93_03988	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HZS93_03989	COG1573	uracil-dna glycosylase
HZS93_03991	COG3384	dioxygenase
HZS93_03993	COG0583	DNA-binding transcription factor activity
HZS93_03995	COG0667	Aldo Keto reductase
HZS93_03998	COG3590	peptidase
HZS93_04002	COG0531	amino acid
HZS93_04005	COG2972	Histidine kinase
HZS93_04010	COG3685	Protein conserved in bacteria
HZS93_04011	COG3546	catalase activity
HZS93_04021	COG1271	oxidase subunit
HZS93_04022	COG1294	oxidase, subunit
HZS93_04025	COG1028	Short-chain dehydrogenase reductase Sdr
HZS93_04026	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HZS93_04030	COG1132	(ABC) transporter
HZS93_04033	COG1063	alcohol dehydrogenase
HZS93_04048	COG0251	oxidation-reduction process
HZS93_04054	COG0840	transmembrane signaling receptor activity
HZS93_04058	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HZS93_04067	COG0024	Methionine aminopeptidase
HZS93_04074	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZS93_04075	COG1490	D-aminoacyl-tRNA deacylase activity
HZS93_04076	COG1560	Kdo2-lipid A biosynthetic process
HZS93_04087	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HZS93_04087	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZS93_04088	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HZS93_04089	COG0242	peptide deformylase activity
HZS93_04090	COG1652	LysM domain
HZS93_04091	COG0758	DNA mediated transformation
HZS93_04092	COG2922	Belongs to the Smg family
HZS93_04095	COG1754	DNA topoisomerase type I activity
HZS93_04095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZS93_04096	COG0009	L-threonylcarbamoyladenylate synthase
HZS93_04099	COG1028	Short-chain dehydrogenase reductase Sdr
HZS93_04101	COG0616	signal peptide processing
HZS93_04102	COG0534	Mate efflux family protein
HZS93_04106	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HZS93_04107	COG0625	glutathione transferase activity
HZS93_04110	COG1252	NADH dehydrogenase
HZS93_04111	COG2860	membrane
HZS93_04112	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZS93_04113	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HZS93_04114	COG3437	response regulator, receiver
HZS93_04115	COG2177	Part of the ABC transporter FtsEX involved in
HZS93_04116	COG2884	Cell division ATP-binding protein ftsE
HZS93_04117	COG0513	Belongs to the DEAD box helicase family
HZS93_04118	COG3118	belongs to the thioredoxin family
HZS93_04119	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HZS93_04121	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HZS93_04122	COG0583	DNA-binding transcription factor activity
HZS93_04131	COG1518	maintenance of DNA repeat elements
HZS93_04132	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HZS93_04134	COG1652	LysM domain
HZS93_04135	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HZS93_04135	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HZS93_04136	COG1473	amidohydrolase
HZS93_04137	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS93_04138	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZS93_04140	COG5383	Protein conserved in bacteria
HZS93_04151	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HZS93_04152	COG3023	N-Acetylmuramoyl-L-alanine amidase
HZS93_04154	COG4948	Mandelate Racemase Muconate Lactonizing
HZS93_04156	COG0531	amino acid
HZS93_04159	COG4682	membrane
HZS93_04160	COG2133	pyrroloquinoline quinone binding
HZS93_04162	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HZS93_04163	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HZS93_04165	COG1610	YqeY-like protein
HZS93_04167	COG1295	ribonuclease BN
HZS93_04168	COG0358	DNA primase activity
HZS93_04171	COG0109	protoheme IX farnesyltransferase activity
HZS93_04177	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HZS93_04180	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HZS93_04189	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HZS93_04190	COG0739	heme binding
HZS93_04191	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HZS93_04193	COG2211	Major facilitator Superfamily
HZS93_04194	COG0708	Exodeoxyribonuclease III
HZS93_04195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HZS93_04197	COG1192	Involved in chromosome partitioning
HZS93_04198	COG1475	DNA binding
HZS93_04202	COG0463	Glycosyl transferase, family 2
HZS93_04206	COG0756	dUTP diphosphatase activity
HZS93_04207	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZS93_04208	COG2003	Belongs to the UPF0758 family
HZS93_04209	COG0018	arginyl-trna synthetase
HZS93_04212	COG4221	oxidoreductase activity
HZS93_04213	COG2755	lipolytic protein G-D-S-L family
HZS93_04213	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HZS93_04215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZS93_04216	COG1166	arginine decarboxylase activity
HZS93_04217	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HZS93_04226	COG0606	chelatase, subunit chli
HZS93_04238	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZS93_04247	COG0606	chelatase, subunit chli
HZS93_04250	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HZS93_04257	COG1690	Belongs to the RtcB family
HZS93_04264	COG1090	epimerase
HZS93_04266	COG0642	Histidine kinase
HZS93_04272	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZS93_04277	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZS93_04278	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HZS93_04281	COG0753	catalase activity
HZS93_04284	COG2197	response regulator
HZS93_04285	COG4585	Histidine kinase
HZS93_04286	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS93_04287	COG1136	(ABC) transporter
HZS93_04291	COG2962	Rard protein
HZS93_04292	COG0697	spore germination
HZS93_04296	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZS93_04297	COG0180	Tryptophanyl-tRNA synthetase
HZS93_04298	COG3237	CsbD-like
HZS93_04307	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HZS93_04310	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HZS93_04320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZS93_04326	COG1199	ATP-dependent helicase activity
HZS93_04329	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HZS93_04342	COG0625	glutathione transferase activity
HZS93_04350	COG4555	ABC transporter
HZS93_04352	COG1476	TRANSCRIPTIONal
HZS93_04361	COG0633	Ferredoxin
HZS93_04361	COG0543	2 iron, 2 sulfur cluster binding
HZS93_04362	COG1131	(ABC) transporter
HZS93_04363	COG0842	Transport permease protein
HZS93_04365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HZS93_04372	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZS93_04373	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZS93_04376	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZS93_04376	COG1042	CoA-binding domain protein
HZS93_04376	COG0045	succinate-CoA ligase (ADP-forming) activity
HZS93_04377	COG2239	Acts as a magnesium transporter
HZS93_04378	COG3338	carbonate dehydratase activity
HZS93_04380	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HZS93_04381	COG3387	PFAM Glycoside hydrolase 15-related
HZS93_04384	COG3100	YcgL domain-containing protein
HZS93_04385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZS93_04387	COG0463	Glycosyl transferase, family 2
HZS93_04391	COG1028	Short-chain dehydrogenase reductase Sdr
HZS93_04398	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZS93_04401	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZS93_04407	COG1506	peptidase
HZS93_04407	COG4946	Tricorn protease homolog
HZS93_04407	COG0823	Involved in the tonB-independent uptake of proteins
HZS93_04411	COG0408	coproporphyrinogen oxidase activity
HZS93_04419	COG0515	serine threonine protein kinase
HZS93_04419	COG2815	serine threonine protein kinase
HZS93_04420	COG0631	protein serine/threonine phosphatase activity
HZS93_04455	COG0210	DNA helicase
HZS93_04458	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZS93_04459	COG0583	DNA-binding transcription factor activity
HZS93_04460	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HZS93_04463	COG2159	amidohydrolase
HZS93_04467	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS93_04471	COG0357	Ribosomal RNA small subunit methyltransferase G
HZS93_04472	COG3540	Alkaline phosphatase
HZS93_04474	COG2091	lysine biosynthetic process via aminoadipic acid
HZS93_04477	COG0708	Exodeoxyribonuclease III
HZS93_04478	COG1846	Transcriptional regulator
HZS93_04478	COG1940	carbohydrate kinase activity
HZS93_04480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZS93_04482	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZS93_04483	COG3162	membrane
HZS93_04485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZS93_04491	COG3507	Belongs to the glycosyl hydrolase 43 family
HZS93_04495	COG1028	Short-chain dehydrogenase reductase Sdr
HZS93_04496	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZS93_04498	COG4948	Mandelate Racemase Muconate Lactonizing
HZS93_04499	COG3254	rhamnose metabolic process
HZS93_04500	COG0738	Major facilitator superfamily
HZS93_04501	COG1414	Transcriptional regulator
HZS93_04502	COG1971	Probably functions as a manganese efflux pump
HZS93_04503	COG2205	protein histidine kinase activity
HZS93_04506	COG3459	Glycosyltransferase 36 associated
HZS93_04507	COG2211	Major facilitator Superfamily
HZS93_04508	COG3265	gluconokinase activity
HZS93_04510	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZS93_04514	COG2911	Protein conserved in bacteria
HZS93_04515	COG0729	surface antigen
HZS93_04525	COG0752	glycyl-tRNA synthetase alpha subunit
HZS93_04526	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZS93_04529	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HZS93_04529	COG0519	Catalyzes the synthesis of GMP from XMP
HZS93_04531	COG0805	protein transport
HZS93_04532	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZS93_04533	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZS93_04535	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HZS93_04540	COG2974	May be involved in recombination
HZS93_04541	COG0037	tRNA processing
HZS93_04543	COG2115	Belongs to the xylose isomerase family
HZS93_04545	COG3661	Belongs to the glycosyl hydrolase 67 family
HZS93_04547	COG4948	Mandelate Racemase Muconate Lactonizing
HZS93_04549	COG1472	Belongs to the glycosyl hydrolase 3 family
HZS93_04550	COG0246	Mannitol dehydrogenase
HZS93_04560	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZS93_04566	COG3386	PFAM SMP-30 Gluconolaconase
HZS93_04568	COG3250	beta-galactosidase activity
HZS93_04569	COG1904	glucuronate isomerase
HZS93_04570	COG3693	PFAM glycoside hydrolase, family 10
HZS93_04572	COG3693	PFAM glycoside hydrolase, family 10
HZS93_04575	COG2211	Major facilitator Superfamily
HZS93_04589	COG2937	Belongs to the GPAT DAPAT family
HZS93_04596	COG0284	orotidine-5'-phosphate decarboxylase activity
HZS93_04597	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HZS93_04599	COG3132	Protein of unknown function, DUF480
HZS93_04602	COG0210	DNA helicase
HZS93_04603	COG1435	thymidine kinase activity
HZS93_04605	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HZS93_04607	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HZS93_04614	COG3135	benzoate transporter
HZS93_04618	COG0676	glucose-6-phosphate 1-epimerase activity
HZS93_04620	COG3012	SEC-C Motif Domain Protein
HZS93_04621	COG0730	response to heat
HZS93_04626	COG0302	gtp cyclohydrolase
HZS93_04629	COG1566	PFAM secretion protein HlyD family protein
HZS93_04631	COG1289	transmembrane transporter activity
HZS93_04632	COG0477	Major facilitator Superfamily
HZS93_04633	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HZS93_04634	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZS93_04638	COG4691	Plasmid stability protein
HZS93_04639	COG1487	ribonuclease activity
HZS93_04646	COG0564	pseudouridine synthase activity
HZS93_04653	COG0439	Biotin carboxylase
HZS93_04661	COG1074	ATP-dependent DNA helicase activity
HZS93_04662	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HZS93_04665	COG1127	ABC transporter
HZS93_04666	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HZS93_04667	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HZS93_04670	COG2853	Lipoprotein
HZS93_04672	COG0386	Belongs to the glutathione peroxidase family
HZS93_04674	COG1322	Protein conserved in bacteria
HZS93_04675	COG0604	alcohol dehydrogenase
HZS93_04679	COG0625	glutathione transferase activity
HZS93_04681	COG0531	amino acid
HZS93_04683	COG3537	Alpha-1,2-mannosidase
HZS93_04686	COG3706	GGDEF domain
HZS93_04687	COG3835	regulator
HZS93_04688	COG1929	Belongs to the glycerate kinase type-1 family
HZS93_04689	COG2271	Major facilitator Superfamily
HZS93_04692	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HZS93_04694	COG0861	Integral membrane protein TerC family
HZS93_04697	COG0584	glycerophosphoryl diester phosphodiesterase
HZS93_04700	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HZS93_04701	COG0726	polysaccharide deacetylase
HZS93_04702	COG0706	membrane insertase activity
HZS93_04703	COG0594	ribonuclease P activity
HZS93_04707	COG3250	beta-galactosidase activity
HZS93_04710	COG0534	Mate efflux family protein
HZS93_04718	COG4993	Dehydrogenase
HZS93_04720	COG1073	alpha beta
HZS93_04720	COG2226	methyltransferase
HZS93_04733	COG2132	Multicopper oxidase
HZS93_04736	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZS93_06002	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZS93_06031	COG3012	SEC-C Motif Domain Protein
HZS93_06031	COG3318	Belongs to the UPF0149 family
HZS93_06037	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZS93_06047	COG2951	lytic endotransglycosylase activity
HZS93_06048	COG4644	lycopene metabolic process
HZS93_06061	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZS93_06065	COG3012	SEC-C Motif Domain Protein
HZS93_06065	COG3318	Belongs to the UPF0149 family
HZS93_06072	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZS93_06074	COG4456	Virulence-associated protein
HZS93_06095	COG3504	Conjugal transfer protein
HZS93_06096	COG2948	multi-organism process
HZS93_06123	COG1192	Involved in chromosome partitioning
HZS93_07002	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZS93_07021	COG1199	ATP-dependent helicase activity
HZS93_07023	COG0745	RESPONSE REGULATOR receiver
HZS93_07027	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HZS93_07039	COG1525	nuclease
HZS93_07050	COG1475	DNA binding
HZS93_07057	COG0629	single-stranded DNA binding
HZS93_07063	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HZS93_07084	COG4232	protein-disulfide reductase activity
HZS93_07103	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZS93_07121	COG4644	lycopene metabolic process
HZS93_07130	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HZS93_07131	COG0431	NADPH-dependent FMN reductase
HZS93_07133	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZS93_07136	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZS93_07141	COG2132	Multicopper oxidase
HZS93_07148	COG0010	Belongs to the arginase family
HZS93_07149	COG2986	histidine ammonia-lyase
HZS93_07150	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HZS93_07151	COG2188	Transcriptional regulator
HZS93_07155	COG2871	sodium ion transport
HZS93_07160	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZS93_07161	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS93_07164	COG2217	Heavy metal translocating P-type atpase
HZS93_07165	COG2217	Heavy metal translocating P-type atpase
HZS93_07167	COG1063	alcohol dehydrogenase
HZS93_07179	COG1063	alcohol dehydrogenase
HZS93_07181	COG2217	Heavy metal translocating P-type atpase
HZS93_07182	COG2217	Heavy metal translocating P-type atpase
HZS93_07185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS93_07186	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZS93_07191	COG2871	sodium ion transport
HZS93_07195	COG2188	Transcriptional regulator
HZS93_07196	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HZS93_07197	COG2986	histidine ammonia-lyase
HZS93_07198	COG0010	Belongs to the arginase family
HZS93_07205	COG2132	Multicopper oxidase
HZS93_07210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZS93_07213	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZS93_07215	COG0431	NADPH-dependent FMN reductase
HZS93_07216	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HZS93_07225	COG4644	lycopene metabolic process
HZS93_07262	COG1192	Involved in chromosome partitioning