locus-tag	class	description
AC028_00005	COG2201	protein-glutamate methylesterase activity
AC028_00010	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AC028_00015	COG2201	protein-glutamate methylesterase activity
AC028_00020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC028_00025	COG3590	peptidase
AC028_00035	COG0588	phosphoglycerate mutase activity
AC028_00040	COG1515	deoxyribonuclease V activity
AC028_00050	COG1741	Belongs to the pirin family
AC028_00065	COG1741	Belongs to the pirin family
AC028_00070	COG1966	Carbon starvation protein
AC028_00075	COG2879	small protein
AC028_00125	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AC028_00130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC028_00135	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AC028_00140	COG2080	2 iron, 2 sulfur cluster binding
AC028_00145	COG0604	alcohol dehydrogenase
AC028_00145	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_00145	COG3321	synthase
AC028_00150	COG3706	GGDEF domain
AC028_00150	COG5001	Diguanylate cyclase
AC028_00150	COG2203	Gaf domain
AC028_00150	COG4251	negative regulation of phosphorylation
AC028_00155	COG0629	single-stranded DNA binding
AC028_00160	COG0142	geranyltranstransferase activity
AC028_00170	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AC028_00185	COG0527	aspartate kinase activity
AC028_00190	COG0384	phenazine biosynthesis protein PhzF
AC028_00195	COG0384	phenazine biosynthesis protein PhzF
AC028_00205	COG1764	response to oxidative stress
AC028_00210	COG0540	Belongs to the ATCase OTCase family
AC028_00215	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AC028_00220	COG1678	Uncharacterized ACR, COG1678
AC028_00230	COG0519	Catalyzes the synthesis of GMP from XMP
AC028_00255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AC028_00270	COG0739	heme binding
AC028_00290	COG0693	protein deglycase activity
AC028_00300	COG1959	2 iron, 2 sulfur cluster binding
AC028_00305	COG0719	Fe-S assembly protein
AC028_00310	COG0396	ATPase activity
AC028_00315	COG0719	Fe-S assembly protein
AC028_00320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AC028_00335	COG4774	siderophore transport
AC028_00340	COG3128	pkhd-type hydroxylase
AC028_00365	COG1477	protein flavinylation
AC028_00370	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AC028_00380	COG1555	photosystem II stabilization
AC028_00395	COG3178	'Phosphotransferase
AC028_00400	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AC028_00410	COG0628	permease
AC028_00420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AC028_00430	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AC028_00450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AC028_00455	COG0271	Belongs to the BolA IbaG family
AC028_00465	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AC028_00475	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AC028_00480	COG1137	ATPase activity
AC028_00495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC028_00500	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AC028_00505	COG1660	Displays ATPase and GTPase activities
AC028_00515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC028_00520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AC028_00525	COG2239	Acts as a magnesium transporter
AC028_00535	COG1294	oxidase, subunit
AC028_00540	COG1271	oxidase subunit
AC028_00550	COG1113	amino acid transport
AC028_00570	COG2197	response regulator
AC028_00575	COG0531	amino acid
AC028_00650	COG2814	Major facilitator Superfamily
AC028_00660	COG0754	glutathionylspermidine amidase activity
AC028_00685	COG1842	Phage shock protein A
AC028_00695	COG0259	pyridoxamine-phosphate oxidase activity
AC028_00700	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AC028_00705	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AC028_00715	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AC028_00720	COG0477	Major facilitator Superfamily
AC028_00755	COG0784	Response regulator, receiver
AC028_00755	COG2198	Histidine kinase
AC028_00755	COG2205	protein histidine kinase activity
AC028_00760	COG2353	YceI-like domain
AC028_00780	COG1760	l-serine dehydratase
AC028_00795	COG0527	aspartate kinase activity
AC028_00795	COG0460	homoserine dehydrogenase
AC028_00800	COG0626	cystathionine gamma-synthase activity
AC028_00805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC028_00810	COG0739	heme binding
AC028_00815	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AC028_00820	COG1272	protein, Hemolysin III
AC028_00825	COG2982	Protein involved in outer membrane biogenesis
AC028_00830	COG0516	GMP reductase activity
AC028_00830	COG0517	IMP dehydrogenase activity
AC028_00835	COG0463	Glycosyl transferase, family 2
AC028_00840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC028_00845	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AC028_00855	COG4771	TonB-dependent receptor
AC028_00860	COG1309	transcriptional regulator
AC028_00865	COG2267	carboxylic ester hydrolase activity
AC028_00870	COG1960	acyl-CoA dehydrogenase activity
AC028_00900	COG0509	glycine decarboxylation via glycine cleavage system
AC028_00905	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AC028_00915	COG1742	UPF0060 membrane protein
AC028_00920	COG3956	TIGRFAM MazG family protein
AC028_00925	COG1218	3'(2'),5'-bisphosphate nucleotidase
AC028_00930	COG0494	nUDIX hydrolase
AC028_00940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AC028_00945	COG0837	glucose binding
AC028_00960	COG1388	LysM domain
AC028_00960	COG3858	chitin binding
AC028_00965	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AC028_00975	COG1472	Belongs to the glycosyl hydrolase 3 family
AC028_00995	COG1486	melibiose metabolic process
AC028_01005	COG3537	Alpha-1,2-mannosidase
AC028_01040	COG3142	Participates in the control of copper homeostasis
AC028_01045	COG1446	asparaginase
AC028_01080	COG0840	transmembrane signaling receptor activity
AC028_01085	COG0835	chemotaxis
AC028_01100	COG0189	ligase activity
AC028_01120	COG1199	ATP-dependent helicase activity
AC028_01130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC028_01135	COG1442	glycosyl transferase family 8
AC028_01135	COG1216	Glycosyl transferase, family 2
AC028_01145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AC028_01150	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AC028_01155	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AC028_01160	COG0535	radical SAM domain protein
AC028_01165	COG0535	radical SAM domain protein
AC028_01180	COG0837	glucose binding
AC028_01190	COG1643	Atp-dependent helicase
AC028_01195	COG0783	Belongs to the Dps family
AC028_01200	COG0514	ATP-dependent DNA helicase (RecQ)
AC028_01235	COG0840	transmembrane signaling receptor activity
AC028_01255	COG3920	Histidine kinase
AC028_01270	COG0602	queuosine metabolic process
AC028_01280	COG2885	chlorophyll binding
AC028_01285	COG0823	Involved in the tonB-independent uptake of proteins
AC028_01295	COG0848	biopolymer transport protein
AC028_01305	COG0824	Thioesterase
AC028_01310	COG2255	four-way junction helicase activity
AC028_01315	COG3158	transport of potassium into the cell
AC028_01320	COG0632	four-way junction helicase activity
AC028_01325	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AC028_01330	COG0217	transcriptional regulatory protein
AC028_01345	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AC028_01360	COG0477	Major facilitator Superfamily
AC028_01405	COG0488	(ABC) transporter
AC028_01435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AC028_01435	COG4651	solute:proton antiporter activity
AC028_01445	COG4772	TonB-dependent receptor
AC028_01455	COG4264	IucA IucC family
AC028_01470	COG0019	diaminopimelate decarboxylase activity
AC028_01515	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AC028_01525	COG1492	cobalamin metabolic process
AC028_01535	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AC028_01560	COG4206	TonB-dependent receptor
AC028_01570	COG0542	response to heat
AC028_01575	COG1116	anion transmembrane transporter activity
AC028_01580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC028_01590	COG0667	Aldo Keto reductase
AC028_01605	COG4771	TonB-dependent receptor
AC028_01610	COG2827	Endonuclease containing a URI domain
AC028_01650	COG1877	trehalose-phosphatase activity
AC028_01655	COG3387	PFAM Glycoside hydrolase 15-related
AC028_01670	COG0840	transmembrane signaling receptor activity
AC028_01675	COG3011	Protein conserved in bacteria
AC028_01690	COG0564	pseudouridine synthase activity
AC028_01695	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC028_01705	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AC028_01705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC028_01715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AC028_01720	COG0045	succinate-CoA ligase (ADP-forming) activity
AC028_01740	COG4969	Belongs to the N-Me-Phe pilin family
AC028_01755	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AC028_01760	COG0237	dephospho-CoA kinase activity
AC028_01765	COG3039	Transposase
AC028_01770	COG2801	Transposase and inactivated derivatives
AC028_01775	COG2963	transposase activity
AC028_01790	COG0745	RESPONSE REGULATOR receiver
AC028_01800	COG0189	ligase activity
AC028_01840	COG2801	Transposase and inactivated derivatives
AC028_01845	COG2963	transposase activity
AC028_01870	COG2022	thiamine diphosphate biosynthetic process
AC028_01875	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AC028_01880	COG0471	metal ion transport
AC028_01880	COG3273	potassium ion transport
AC028_01905	COG1970	mechanosensitive ion channel activity
AC028_01920	COG1609	Transcriptional regulator
AC028_01930	COG3250	beta-galactosidase activity
AC028_01935	COG4948	Mandelate Racemase Muconate Lactonizing
AC028_01950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC028_01960	COG0308	aminopeptidase N
AC028_01985	COG2963	transposase activity
AC028_01990	COG2801	Transposase and inactivated derivatives
AC028_02020	COG3039	Transposase
AC028_02025	COG2801	Transposase and inactivated derivatives
AC028_02030	COG2963	transposase activity
AC028_02045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC028_02050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC028_02055	COG0529	Catalyzes the synthesis of activated sulfate
AC028_02055	COG2895	sulfate adenylyltransferase (ATP) activity
AC028_02060	COG0175	sulfate reduction
AC028_02065	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AC028_02070	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC028_02075	COG0175	sulfate reduction
AC028_02130	COG3588	fructose-bisphosphate aldolase
AC028_02135	COG0469	pyruvate kinase activity
AC028_02145	COG0126	phosphoglycerate kinase activity
AC028_02165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AC028_02175	COG3047	cAMP biosynthetic process
AC028_02190	COG3453	Protein conserved in bacteria
AC028_02190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC028_02195	COG0725	ABC transporter, periplasmic molybdate-binding protein
AC028_02200	COG4149	molybdate abc transporter
AC028_02205	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AC028_02240	COG1376	ErfK ybiS ycfS ynhG family protein
AC028_02245	COG0739	heme binding
AC028_02250	COG4773	Receptor
AC028_02285	COG3039	Transposase
AC028_02290	COG3039	Transposase
AC028_02295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AC028_02310	COG2304	oxidoreductase activity
AC028_02330	COG0714	Associated with various cellular activities
AC028_02360	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AC028_02375	COG0254	rRNA binding
AC028_02385	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AC028_02395	COG2721	sulfolactate sulfo-lyase activity
AC028_02410	COG2271	Major facilitator Superfamily
AC028_02425	COG0583	DNA-binding transcription factor activity
AC028_02430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AC028_02435	COG1758	RNA polymerase activity
AC028_02445	COG1561	YicC-like family, N-terminal region
AC028_02450	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AC028_02460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AC028_02465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AC028_02480	COG0006	proline dipeptidase activity
AC028_02485	COG0006	proline dipeptidase activity
AC028_02490	COG3079	Belongs to the UPF0149 family
AC028_02505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AC028_02515	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AC028_02525	COG2912	Transglutaminase-like superfamily
AC028_02530	COG1773	rubredoxin
AC028_02535	COG0352	thiamine-phosphate diphosphorylase activity
AC028_02545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AC028_02560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC028_02590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AC028_02595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC028_02600	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_02610	COG0671	phosphoesterase, PA-phosphatase related
AC028_02615	COG3781	membrane
AC028_02625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AC028_02630	COG0563	adenylate kinase activity
AC028_02645	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AC028_02655	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AC028_02675	COG3710	Transcriptional regulator
AC028_02680	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AC028_02690	COG0840	transmembrane signaling receptor activity
AC028_02700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AC028_02720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AC028_02725	COG0473	3-isopropylmalate dehydrogenase activity
AC028_02730	COG0066	3-isopropylmalate dehydratase activity
AC028_02735	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AC028_02755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AC028_02760	COG1538	Outer membrane efflux protein
AC028_02765	COG1519	Transferase
AC028_02770	COG1560	Kdo2-lipid A biosynthetic process
AC028_02805	COG2801	Transposase and inactivated derivatives
AC028_02810	COG2963	transposase activity
AC028_02815	COG3039	Transposase
AC028_02820	COG0436	Aminotransferase
AC028_02835	COG0726	polysaccharide deacetylase
AC028_02840	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AC028_02855	COG3964	amidohydrolase
AC028_02860	COG0402	S-adenosylhomocysteine deaminase activity
AC028_02880	COG1307	EDD domain protein, DegV family
AC028_02885	COG0242	peptide deformylase activity
AC028_02910	COG0457	Tetratricopeptide repeat
AC028_02915	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AC028_02920	COG1215	transferase activity, transferring glycosyl groups
AC028_02925	COG1215	transferase activity, transferring glycosyl groups
AC028_02940	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AC028_02990	COG2188	Transcriptional regulator
AC028_03000	COG1450	Type ii and iii secretion system protein
AC028_03015	COG3166	PFAM Fimbrial assembly family protein
AC028_03020	COG3156	type II secretion system protein K
AC028_03025	COG4795	General secretion pathway protein
AC028_03030	COG2165	general secretion pathway protein
AC028_03035	COG4970	Tfp pilus assembly protein FimT
AC028_03040	COG2165	general secretion pathway protein
AC028_03045	COG1459	type II secretion system
AC028_03050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AC028_03055	COG1404	Belongs to the peptidase S8 family
AC028_03065	COG3039	Transposase
AC028_03080	COG0047	phosphoribosylformylglycinamidine synthase activity
AC028_03080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AC028_03085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC028_03090	COG4974	Belongs to the 'phage' integrase family
AC028_03105	COG0795	lipopolysaccharide-transporting ATPase activity
AC028_03115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AC028_03130	COG0525	valine-tRNA ligase activity
AC028_03140	COG0741	lytic transglycosylase activity
AC028_03160	COG1183	phosphatidylcholine synthase activity
AC028_03170	COG0442	prolyl-tRNA aminoacylation
AC028_03225	COG5489	Protein of unknown function (DUF736)
AC028_03255	COG1192	Involved in chromosome partitioning
AC028_03285	COG2814	Major facilitator Superfamily
AC028_03310	COG0446	pyridine nucleotide-disulphide oxidoreductase
AC028_03310	COG1902	pentaerythritol trinitrate reductase activity
AC028_03315	COG0583	DNA-binding transcription factor activity
AC028_03335	COG4962	Type ii secretion system protein e
AC028_03340	COG3838	Conjugal transfer protein Trbc
AC028_03350	COG3451	type IV secretory pathway VirB4
AC028_03390	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC028_03390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC028_03420	COG1595	DNA-templated transcription, initiation
AC028_03445	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AC028_03460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AC028_03465	COG0251	oxidation-reduction process
AC028_03475	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AC028_03475	COG0392	lysyltransferase activity
AC028_03510	COG2814	Major facilitator Superfamily
AC028_03515	COG1902	pentaerythritol trinitrate reductase activity
AC028_03520	COG2824	Alkylphosphonate utilization operon protein PhnA
AC028_03530	COG1047	Peptidyl-prolyl cis-trans
AC028_03535	COG1077	Cell shape determining protein MreB Mrl
AC028_03555	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AC028_03565	COG5487	UPF0391 membrane protein
AC028_03570	COG1451	nucleotide metabolic process
AC028_03585	COG0183	Belongs to the thiolase family
AC028_03615	COG1793	dna ligase
AC028_03615	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AC028_03625	COG1793	dna ligase
AC028_03630	COG1201	RNA secondary structure unwinding
AC028_03640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC028_03645	COG1278	Cold shock
AC028_03650	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AC028_03660	COG1472	Belongs to the glycosyl hydrolase 3 family
AC028_03665	COG3046	protein related to deoxyribodipyrimidine photolyase
AC028_03670	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AC028_03675	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AC028_03685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AC028_03695	COG1381	Involved in DNA repair and RecF pathway recombination
AC028_03700	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AC028_03705	COG0571	ribonuclease III activity
AC028_03720	COG0481	GTPase activity
AC028_03725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC028_03740	COG1024	Enoyl-CoA hydratase
AC028_03740	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC028_03760	COG1166	arginine decarboxylase activity
AC028_03765	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AC028_03805	COG0606	chelatase, subunit chli
AC028_03820	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AC028_03855	COG1690	Belongs to the RtcB family
AC028_03900	COG0745	RESPONSE REGULATOR receiver
AC028_03905	COG0642	Histidine kinase
AC028_03930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC028_03955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AC028_03960	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AC028_03970	COG0753	catalase activity
AC028_03985	COG2197	response regulator
AC028_03990	COG4585	Histidine kinase
AC028_03995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC028_04000	COG1136	(ABC) transporter
AC028_04025	COG0697	spore germination
AC028_04040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC028_04045	COG0180	Tryptophanyl-tRNA synthetase
AC028_04050	COG3237	CsbD-like
AC028_04090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AC028_04105	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AC028_04110	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AC028_04110	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AC028_04135	COG2205	protein histidine kinase activity
AC028_04140	COG0745	RESPONSE REGULATOR receiver
AC028_04150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AC028_04175	COG1199	ATP-dependent helicase activity
AC028_04190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AC028_04255	COG0625	glutathione transferase activity
AC028_04290	COG4555	ABC transporter
AC028_04300	COG1476	TRANSCRIPTIONal
AC028_04320	COG1230	cation diffusion facilitator family transporter
AC028_04325	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AC028_04330	COG1131	(ABC) transporter
AC028_04335	COG0842	Transport permease protein
AC028_04340	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AC028_04370	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AC028_04380	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AC028_04390	COG0045	succinate-CoA ligase (ADP-forming) activity
AC028_04390	COG1042	CoA-binding domain protein
AC028_04390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AC028_04395	COG2239	Acts as a magnesium transporter
AC028_04410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AC028_04415	COG3387	PFAM Glycoside hydrolase 15-related
AC028_04425	COG3100	YcgL domain-containing protein
AC028_04430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AC028_04440	COG0463	Glycosyl transferase, family 2
AC028_04450	COG3039	Transposase
AC028_04455	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_04495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC028_04510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AC028_04535	COG1506	peptidase
AC028_04535	COG0823	Involved in the tonB-independent uptake of proteins
AC028_04535	COG4946	Tricorn protease homolog
AC028_04550	COG0408	coproporphyrinogen oxidase activity
AC028_04585	COG0515	serine threonine protein kinase
AC028_04585	COG2815	serine threonine protein kinase
AC028_04590	COG0631	protein serine/threonine phosphatase activity
AC028_04615	COG0667	Aldo Keto reductase
AC028_04620	COG0583	DNA-binding transcription factor activity
AC028_04635	COG3501	Rhs element vgr protein
AC028_04660	COG1595	DNA-templated transcription, initiation
AC028_04690	COG2801	Transposase and inactivated derivatives
AC028_04695	COG2963	transposase activity
AC028_04725	COG1082	Xylose isomerase domain protein TIM barrel
AC028_04745	COG2801	Transposase and inactivated derivatives
AC028_04750	COG2963	transposase activity
AC028_04755	COG3039	Transposase
AC028_04765	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AC028_04765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC028_04775	COG0366	Alpha amylase catalytic
AC028_04780	COG0366	Alpha amylase catalytic
AC028_04785	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC028_04805	COG2755	lipolytic protein G-D-S-L family
AC028_04805	COG0657	acetylesterase activity
AC028_04815	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC028_04830	COG3507	Belongs to the glycosyl hydrolase 43 family
AC028_04835	COG1609	Transcriptional regulator
AC028_04840	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AC028_04845	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_04855	COG2755	lipolytic protein G-D-S-L family
AC028_04865	COG3186	Phenylalanine-4-hydroxylase
AC028_04870	COG1522	sequence-specific DNA binding
AC028_04880	COG1752	Esterase of the alpha-beta hydrolase superfamily
AC028_04890	COG1119	ATPase activity
AC028_04905	COG1125	glycine betaine transport
AC028_04905	COG0517	IMP dehydrogenase activity
AC028_04920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AC028_04955	COG0489	protein tyrosine kinase activity
AC028_04960	COG2062	phosphohistidine phosphatase, SixA
AC028_04970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC028_05015	COG1968	undecaprenyl-diphosphatase activity
AC028_05020	COG0174	glutamine synthetase
AC028_05025	COG0347	Belongs to the P(II) protein family
AC028_05030	COG0004	ammonium transporteR
AC028_05035	COG3852	Histidine kinase
AC028_05040	COG2204	response regulator
AC028_05045	COG2032	superoxide dismutase activity
AC028_05050	COG2032	superoxide dismutase activity
AC028_05055	COG0346	lactoylglutathione lyase activity
AC028_05065	COG0183	Belongs to the thiolase family
AC028_05100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AC028_05105	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AC028_05110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AC028_05130	COG0028	Belongs to the TPP enzyme family
AC028_05135	COG2205	protein histidine kinase activity
AC028_05160	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AC028_05175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC028_05185	COG0596	Alpha beta hydrolase
AC028_05195	COG0318	PFAM AMP-dependent synthetase and ligase
AC028_05210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC028_05235	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AC028_05245	COG0564	pseudouridine synthase activity
AC028_05265	COG1446	asparaginase
AC028_05270	COG0339	signal peptide processing
AC028_05305	COG0475	glutathione-regulated potassium exporter activity
AC028_05310	COG0583	DNA-binding transcription factor activity
AC028_05315	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AC028_05320	COG2224	Isocitrate lyase
AC028_05325	COG3706	GGDEF domain
AC028_05350	COG2801	Transposase and inactivated derivatives
AC028_05355	COG2963	transposase activity
AC028_05370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AC028_05375	COG1960	acyl-CoA dehydrogenase activity
AC028_05445	COG0697	spore germination
AC028_05455	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AC028_05460	COG1846	Transcriptional regulator
AC028_05465	COG1764	response to oxidative stress
AC028_05495	COG2130	NADP-dependent
AC028_05510	COG1187	pseudouridine synthase activity
AC028_05525	COG1643	Atp-dependent helicase
AC028_05530	COG4807	Protein conserved in bacteria
AC028_05535	COG2351	hydroxyisourate hydrolase activity
AC028_05540	COG2072	flavoprotein involved in K transport
AC028_05560	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AC028_05570	COG0583	DNA-binding transcription factor activity
AC028_05605	COG2252	PERMEase
AC028_05630	COG0084	hydrolase, TatD family'
AC028_05640	COG0583	DNA-binding transcription factor activity
AC028_05645	COG2814	Major facilitator Superfamily
AC028_05655	COG2267	carboxylic ester hydrolase activity
AC028_05660	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AC028_05665	COG1902	pentaerythritol trinitrate reductase activity
AC028_05685	COG0745	RESPONSE REGULATOR receiver
AC028_05690	COG2205	protein histidine kinase activity
AC028_05695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC028_05715	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AC028_05720	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AC028_05725	COG0583	DNA-binding transcription factor activity
AC028_05765	COG0702	epimerase
AC028_05770	COG1733	regulation of RNA biosynthetic process
AC028_05805	COG0129	dihydroxy-acid dehydratase activity
AC028_05825	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AC028_05880	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AC028_05885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AC028_05910	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AC028_05915	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AC028_05925	COG3485	protocatechuate 3,4-dioxygenase
AC028_05930	COG3485	protocatechuate 3,4-dioxygenase
AC028_05940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC028_05945	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AC028_05955	COG1414	Transcriptional regulator
AC028_05980	COG0445	tRNA wobble uridine modification
AC028_06015	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_06020	COG2267	carboxylic ester hydrolase activity
AC028_06030	COG0156	8-amino-7-oxononanoate synthase activity
AC028_06035	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AC028_06040	COG1040	competence protein
AC028_06045	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AC028_06080	COG2963	transposase activity
AC028_06085	COG2801	Transposase and inactivated derivatives
AC028_06100	COG3321	synthase
AC028_06100	COG0604	alcohol dehydrogenase
AC028_06100	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_06105	COG2937	Belongs to the GPAT DAPAT family
AC028_06140	COG0284	orotidine-5'-phosphate decarboxylase activity
AC028_06145	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AC028_06150	COG3132	Protein of unknown function, DUF480
AC028_06165	COG0210	DNA helicase
AC028_06170	COG1435	thymidine kinase activity
AC028_06180	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AC028_06190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AC028_06220	COG3135	benzoate transporter
AC028_06240	COG0676	glucose-6-phosphate 1-epimerase activity
AC028_06250	COG3012	SEC-C Motif Domain Protein
AC028_06255	COG0730	response to heat
AC028_06275	COG0302	gtp cyclohydrolase
AC028_06290	COG1566	PFAM secretion protein HlyD family protein
AC028_06300	COG1289	transmembrane transporter activity
AC028_06305	COG0477	Major facilitator Superfamily
AC028_06315	COG0583	DNA-binding transcription factor activity
AC028_06320	COG4221	oxidoreductase activity
AC028_06330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC028_06395	COG0439	Biotin carboxylase
AC028_06420	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_06450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AC028_06455	COG1074	ATP-dependent DNA helicase activity
AC028_06460	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AC028_06495	COG1127	ABC transporter
AC028_06500	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AC028_06505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AC028_06520	COG2853	Lipoprotein
AC028_06530	COG0386	Belongs to the glutathione peroxidase family
AC028_06540	COG1322	Protein conserved in bacteria
AC028_06550	COG0625	glutathione transferase activity
AC028_06560	COG0531	amino acid
AC028_06575	COG3835	regulator
AC028_06580	COG1929	Belongs to the glycerate kinase type-1 family
AC028_06585	COG2271	Major facilitator Superfamily
AC028_06600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AC028_06605	COG0861	Integral membrane protein TerC family
AC028_06615	COG0584	glycerophosphoryl diester phosphodiesterase
AC028_06630	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AC028_06640	COG0706	membrane insertase activity
AC028_06645	COG0594	ribonuclease P activity
AC028_06650	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AC028_06655	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AC028_06665	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AC028_06670	COG0187	DNA topoisomerase II activity
AC028_06680	COG0501	Belongs to the peptidase M48B family
AC028_06715	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AC028_06725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC028_06755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC028_06760	COG0793	Belongs to the peptidase S41A family
AC028_06765	COG4942	peptidase
AC028_06775	COG2234	aminopeptidase activity
AC028_06785	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC028_06790	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC028_06800	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC028_06805	COG1064	alcohol dehydrogenase
AC028_06840	COG0778	Nitroreductase
AC028_06845	COG2353	YceI-like domain
AC028_06875	COG3052	prosthetic group binding
AC028_06895	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AC028_06900	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AC028_06910	COG1802	Transcriptional regulator
AC028_06970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AC028_06975	COG0752	glycyl-tRNA synthetase alpha subunit
AC028_06990	COG3039	Transposase
AC028_07030	COG3039	Transposase
AC028_07045	COG0729	surface antigen
AC028_07050	COG2911	Protein conserved in bacteria
AC028_07070	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC028_07075	COG3265	gluconokinase activity
AC028_07080	COG2211	Major facilitator Superfamily
AC028_07085	COG3459	Glycosyltransferase 36 associated
AC028_07095	COG2205	protein histidine kinase activity
AC028_07100	COG1971	Probably functions as a manganese efflux pump
AC028_07105	COG1414	Transcriptional regulator
AC028_07110	COG0738	Major facilitator superfamily
AC028_07115	COG3254	rhamnose metabolic process
AC028_07120	COG4948	Mandelate Racemase Muconate Lactonizing
AC028_07125	COG0179	Fumarylacetoacetate (FAA) hydrolase
AC028_07130	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_07150	COG3507	Belongs to the glycosyl hydrolase 43 family
AC028_07180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC028_07190	COG3162	membrane
AC028_07195	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC028_07205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC028_07215	COG1846	Transcriptional regulator
AC028_07215	COG1940	carbohydrate kinase activity
AC028_07220	COG0708	Exodeoxyribonuclease III
AC028_07240	COG2091	lysine biosynthetic process via aminoadipic acid
AC028_07250	COG3540	Alkaline phosphatase
AC028_07255	COG0357	Ribosomal RNA small subunit methyltransferase G
AC028_07275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC028_07285	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AC028_07290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AC028_07295	COG2159	amidohydrolase
AC028_07305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AC028_07310	COG0583	DNA-binding transcription factor activity
AC028_07315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC028_07325	COG0210	DNA helicase
AC028_07400	COG1511	domain protein
AC028_07400	COG3264	Mechanosensitive ion channel
AC028_07405	COG1368	sulfuric ester hydrolase activity
AC028_07410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AC028_07415	COG2354	Protein conserved in bacteria
AC028_07420	COG0745	RESPONSE REGULATOR receiver
AC028_07420	COG3706	GGDEF domain
AC028_07425	COG0297	glycogen (starch) synthase activity
AC028_07430	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC028_07435	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC028_07460	COG0702	epimerase
AC028_07465	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_07500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC028_07505	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_07515	COG0513	Belongs to the DEAD box helicase family
AC028_07520	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC028_07535	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AC028_07545	COG3483	tryptophan 2,3-dioxygenase activity
AC028_07550	COG3104	oligopeptide transport
AC028_07570	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AC028_07585	COG1320	monovalent cation:proton antiporter activity
AC028_07590	COG2212	antiporter activity
AC028_07600	COG0651	ATP synthesis coupled electron transport
AC028_07605	COG1006	Multisubunit Na H antiporter MnhC subunit
AC028_07610	COG2111	Na H antiporter
AC028_07610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC028_07645	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AC028_07650	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AC028_07665	COG0456	acetyltransferase
AC028_07670	COG1597	lipid kinase activity
AC028_07695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AC028_07700	COG0134	indole-3-glycerol-phosphate synthase activity
AC028_07710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC028_07715	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AC028_07725	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AC028_07730	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AC028_07735	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AC028_07750	COG1051	belongs to the nudix hydrolase family
AC028_07790	COG0316	Belongs to the HesB IscA family
AC028_07805	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AC028_07820	COG2814	Major facilitator Superfamily
AC028_07830	COG2814	Major facilitator Superfamily
AC028_07835	COG1289	transmembrane transporter activity
AC028_07845	COG0151	Belongs to the GarS family
AC028_07855	COG0138	bifunctional purine biosynthesis protein purh
AC028_07860	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AC028_07865	COG2267	carboxylic ester hydrolase activity
AC028_07870	COG0671	phosphoesterase, PA-phosphatase related
AC028_07870	COG2453	phosphatase
AC028_07895	COG4589	Belongs to the CDS family
AC028_07900	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AC028_07925	COG2264	protein methyltransferase activity
AC028_07940	COG0439	Biotin carboxylase
AC028_07950	COG0511	ligase activity, forming carbon-carbon bonds
AC028_07955	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AC028_07965	COG1324	tolerance protein
AC028_07970	COG2356	endonuclease I
AC028_07975	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AC028_07980	COG0459	protein refolding
AC028_07995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AC028_08025	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AC028_08060	COG0493	'glutamate synthase
AC028_08065	COG0069	glutamate synthase activity
AC028_08065	COG0070	glutamate synthase
AC028_08065	COG0067	glutamate synthase
AC028_08145	COG1205	dead DEAH box helicase
AC028_08145	COG1111	helicase
AC028_08150	COG1272	protein, Hemolysin III
AC028_08165	COG0300	oxidoreductase activity
AC028_08170	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_08195	COG2249	NAD(P)H dehydrogenase (quinone) activity
AC028_08200	COG3039	Transposase
AC028_08255	COG2963	transposase activity
AC028_08260	COG2801	Transposase and inactivated derivatives
AC028_08270	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AC028_08305	COG3237	CsbD-like
AC028_08360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC028_08365	COG0477	Major facilitator Superfamily
AC028_08415	COG0714	Associated with various cellular activities
AC028_08440	COG3039	Transposase
AC028_08460	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AC028_08465	COG3710	Transcriptional regulator
AC028_08485	COG2197	response regulator
AC028_08490	COG4585	Histidine kinase
AC028_08500	COG1304	FMN binding
AC028_08525	COG1012	belongs to the aldehyde dehydrogenase family
AC028_08540	COG4772	TonB-dependent receptor
AC028_08570	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AC028_08580	COG3039	Transposase
AC028_08595	COG2801	Transposase and inactivated derivatives
AC028_08600	COG2963	transposase activity
AC028_08640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AC028_08640	COG0519	Catalyzes the synthesis of GMP from XMP
AC028_08650	COG0805	protein transport
AC028_08655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC028_08660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC028_08670	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AC028_08690	COG2974	May be involved in recombination
AC028_08695	COG0037	tRNA processing
AC028_08700	COG2115	Belongs to the xylose isomerase family
AC028_08710	COG3661	Belongs to the glycosyl hydrolase 67 family
AC028_08720	COG4948	Mandelate Racemase Muconate Lactonizing
AC028_08735	COG3039	Transposase
AC028_08745	COG0246	Mannitol dehydrogenase
AC028_08790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AC028_08815	COG3386	PFAM SMP-30 Gluconolaconase
AC028_08825	COG3250	beta-galactosidase activity
AC028_08830	COG1904	glucuronate isomerase
AC028_08850	COG3693	PFAM glycoside hydrolase, family 10
AC028_08865	COG2211	Major facilitator Superfamily
AC028_08915	COG2963	transposase activity
AC028_08920	COG2801	Transposase and inactivated derivatives
AC028_08950	COG5297	Belongs to the glycosyl hydrolase family 6
AC028_09005	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AC028_09095	COG4221	oxidoreductase activity
AC028_09110	COG4221	oxidoreductase activity
AC028_09120	COG0435	Glutathione S-transferase
AC028_09155	COG1506	peptidase
AC028_09155	COG0823	Involved in the tonB-independent uptake of proteins
AC028_09170	COG3706	GGDEF domain
AC028_09190	COG0697	spore germination
AC028_09210	COG1113	amino acid transport
AC028_09220	COG0598	Magnesium transport protein CorA
AC028_09230	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AC028_09265	COG0840	transmembrane signaling receptor activity
AC028_09270	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC028_09270	COG5297	Belongs to the glycosyl hydrolase family 6
AC028_09275	COG0659	secondary active sulfate transmembrane transporter activity
AC028_09280	COG3706	GGDEF domain
AC028_09290	COG2943	transferase activity, transferring hexosyl groups
AC028_09300	COG3275	phosphorelay sensor kinase activity
AC028_09310	COG0181	hydroxymethylbilane synthase activity
AC028_09335	COG1505	serine-type exopeptidase activity
AC028_09350	COG2832	Protein of unknown function (DUF454)
AC028_09360	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AC028_09370	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AC028_09375	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AC028_09380	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AC028_09405	COG2226	methyltransferase
AC028_09410	COG3300	MHYT domain
AC028_09410	COG5001	Diguanylate cyclase
AC028_09415	COG0308	aminopeptidase N
AC028_09460	COG3284	Transcriptional regulator
AC028_09470	COG1077	Cell shape determining protein MreB Mrl
AC028_09475	COG1792	Involved in formation and maintenance of cell shape
AC028_09490	COG0772	Belongs to the SEDS family
AC028_09500	COG2951	lytic endotransglycosylase activity
AC028_09505	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AC028_09510	COG1686	Belongs to the peptidase S11 family
AC028_09520	COG2921	Belongs to the UPF0250 family
AC028_09525	COG0321	lipoyl(octanoyl) transferase activity
AC028_09530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AC028_09545	COG0583	DNA-binding transcription factor activity
AC028_09555	COG1051	belongs to the nudix hydrolase family
AC028_09555	COG1056	cytidyltransferase-related domain
AC028_09590	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AC028_09600	COG2823	Periplasmic or secreted lipoprotein
AC028_09605	COG4251	negative regulation of phosphorylation
AC028_09610	COG0784	Response regulator, receiver
AC028_09615	COG4191	Histidine kinase
AC028_09620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AC028_09675	COG1459	type II secretion system
AC028_09695	COG4795	General secretion pathway protein
AC028_09725	COG3250	beta-galactosidase activity
AC028_09750	COG1609	Transcriptional regulator
AC028_09755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AC028_09760	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AC028_09775	COG0617	tRNA 3'-terminal CCA addition
AC028_09780	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AC028_09785	COG1012	belongs to the aldehyde dehydrogenase family
AC028_09790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC028_09800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC028_09815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AC028_09820	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AC028_09840	COG2205	protein histidine kinase activity
AC028_09845	COG0745	RESPONSE REGULATOR receiver
AC028_09870	COG3791	Glutathione-dependent formaldehyde-activating
AC028_09885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC028_09895	COG0697	spore germination
AC028_09905	COG0488	(ABC) transporter
AC028_09915	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AC028_09920	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AC028_09930	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AC028_09930	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AC028_09950	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AC028_09955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC028_09960	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AC028_09980	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AC028_09985	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AC028_09990	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AC028_09995	COG2205	protein histidine kinase activity
AC028_10000	COG0745	RESPONSE REGULATOR receiver
AC028_10005	COG0277	FAD linked oxidase domain protein
AC028_10010	COG1988	membrane-bound metal-dependent
AC028_10015	COG0792	nuclease activity
AC028_10035	COG2001	Belongs to the MraZ family
AC028_10040	COG0275	rRNA processing
AC028_10045	COG3116	cell division
AC028_10060	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AC028_10065	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AC028_10070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AC028_10080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AC028_10085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AC028_10090	COG1181	Belongs to the D-alanine--D-alanine ligase family
AC028_10095	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AC028_10110	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AC028_10120	COG0739	heme binding
AC028_10125	COG0653	protein targeting
AC028_10130	COG0494	nUDIX hydrolase
AC028_10140	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AC028_10150	COG3321	synthase
AC028_10150	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_10150	COG0604	alcohol dehydrogenase
AC028_10170	COG0366	Alpha amylase catalytic
AC028_10205	COG2226	methyltransferase
AC028_10210	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AC028_10225	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AC028_10265	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AC028_10275	COG4106	trans-aconitate 2-methyltransferase activity
AC028_10280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AC028_10290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC028_10295	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AC028_10300	COG0667	Aldo Keto reductase
AC028_10310	COG4771	TonB-dependent receptor
AC028_10330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC028_10335	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AC028_10345	COG2175	clavaminate synthase activity
AC028_10355	COG4181	ATPase activity
AC028_10370	COG0642	Histidine kinase
AC028_10380	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AC028_10400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AC028_10405	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AC028_10420	COG3829	transcription factor binding
AC028_10430	COG1116	anion transmembrane transporter activity
AC028_10435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC028_10445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC028_10450	COG0431	NADPH-dependent FMN reductase
AC028_10460	COG3039	Transposase
AC028_10475	COG0747	negative chemotaxis
AC028_10495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AC028_10500	COG2967	ApaG domain
AC028_10505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AC028_10510	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AC028_10515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC028_10520	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AC028_10525	COG0123	including yeast histone deacetylase and acetoin utilization protein
AC028_10530	COG2096	Adenosyltransferase
AC028_10540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC028_10545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC028_10575	COG3384	dioxygenase
AC028_10580	COG0583	DNA-binding transcription factor activity
AC028_10595	COG1024	Enoyl-CoA hydratase
AC028_10625	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AC028_10650	COG0697	spore germination
AC028_10660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC028_10675	COG3706	GGDEF domain
AC028_10675	COG0745	RESPONSE REGULATOR receiver
AC028_10685	COG2197	response regulator
AC028_10695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AC028_10705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AC028_10710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC028_10715	COG0583	DNA-binding transcription factor activity
AC028_10720	COG3634	alkyl hydroperoxide reductase activity
AC028_10730	COG2890	protein-(glutamine-N5) methyltransferase activity
AC028_10750	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AC028_10750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AC028_10780	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AC028_10800	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AC028_10805	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AC028_10820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AC028_10825	COG1404	Belongs to the peptidase S8 family
AC028_10830	COG1404	Belongs to the peptidase S8 family
AC028_10835	COG1404	Belongs to the peptidase S8 family
AC028_10840	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AC028_10870	COG1295	ribonuclease BN
AC028_10875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC028_10880	COG1254	Belongs to the acylphosphatase family
AC028_10895	COG0521	Mo-molybdopterin cofactor biosynthetic process
AC028_10905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AC028_10910	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AC028_10920	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AC028_10925	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AC028_10935	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AC028_10940	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AC028_10945	COG0193	aminoacyl-tRNA hydrolase activity
AC028_10950	COG0012	GTP binding
AC028_10970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AC028_10980	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AC028_10985	COG0250	Participates in transcription elongation, termination and antitermination
AC028_10990	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AC028_10995	COG0081	regulation of translation
AC028_11000	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AC028_11005	COG0222	ribosome binding
AC028_11010	COG0085	RNA polymerase activity
AC028_11015	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AC028_11020	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AC028_11025	COG0049	tRNA binding
AC028_11030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AC028_11035	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AC028_11040	COG0051	transcription antitermination factor activity, RNA binding
AC028_11045	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AC028_11050	COG0088	Forms part of the polypeptide exit tunnel
AC028_11055	COG0089	rRNA binding
AC028_11060	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AC028_11065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AC028_11070	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AC028_11075	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AC028_11080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AC028_11085	COG0255	Belongs to the universal ribosomal protein uL29 family
AC028_11090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AC028_11095	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AC028_11100	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AC028_11105	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AC028_11110	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AC028_11115	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AC028_11120	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AC028_11125	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AC028_11130	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AC028_11135	COG1841	ribosomal large subunit assembly
AC028_11140	COG0200	Binds to the 23S rRNA
AC028_11145	COG0201	protein transport
AC028_11150	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AC028_11155	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AC028_11160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AC028_11165	COG0202	RNA polymerase activity
AC028_11170	COG0203	ribosomal protein L17
AC028_11175	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AC028_11190	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AC028_11200	COG0154	amidase activity
AC028_11215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AC028_11220	COG0039	L-malate dehydrogenase activity
AC028_11225	COG0625	glutathione transferase activity
AC028_11235	COG0446	pyridine nucleotide-disulphide oxidoreductase
AC028_11235	COG1902	pentaerythritol trinitrate reductase activity
AC028_11240	COG0604	alcohol dehydrogenase
AC028_11265	COG0156	8-amino-7-oxononanoate synthase activity
AC028_11270	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AC028_11275	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AC028_11280	COG4208	sulfate ABC transporter
AC028_11285	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AC028_11295	COG1063	alcohol dehydrogenase
AC028_11315	COG0406	alpha-ribazole phosphatase activity
AC028_11320	COG0285	dihydrofolate synthase activity
AC028_11340	COG2833	Protein of unknown function (DUF455)
AC028_11355	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC028_11360	COG0671	phosphoesterase, PA-phosphatase related
AC028_11365	COG0438	transferase activity, transferring glycosyl groups
AC028_11375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AC028_11390	COG4783	chaperone-mediated protein folding
AC028_11405	COG0473	3-isopropylmalate dehydrogenase activity
AC028_11450	COG0544	peptidyl-prolyl cis-trans isomerase activity
AC028_11455	COG0740	serine-type endopeptidase activity
AC028_11460	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AC028_11490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC028_11500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC028_11510	COG0328	RNA-DNA hybrid ribonuclease activity
AC028_11515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AC028_11520	COG0631	protein serine/threonine phosphatase activity
AC028_11535	COG0859	PFAM glycosyl transferase family 9
AC028_11540	COG3642	lipopolysaccharide core region biosynthetic process
AC028_11545	COG1234	tRNA 3'-trailer cleavage
AC028_11550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AC028_11560	COG0315	cyclic pyranopterin monophosphate synthase activity
AC028_11565	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AC028_11570	COG0314	molybdopterin synthase activity
AC028_11585	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AC028_11590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AC028_11595	COG0537	adenosine 5'-monophosphoramidase activity
AC028_11615	COG0714	Associated with various cellular activities
AC028_11635	COG0424	maF-like protein
AC028_11640	COG1399	metal-binding, possibly nucleic acid-binding protein
AC028_11650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC028_11660	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AC028_11665	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_11670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AC028_11680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AC028_11685	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AC028_11710	COG3829	transcription factor binding
AC028_11750	COG2373	Large extracellular alpha-helical protein
AC028_11765	COG4953	penicillin-binding protein 1C
AC028_11775	COG0678	peroxiredoxin activity
AC028_11795	COG0330	HflC and HflK could
AC028_11800	COG0330	HflC and HflK could
AC028_11810	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AC028_11815	COG0308	aminopeptidase N
AC028_11825	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_11830	COG1309	transcriptional regulator
AC028_11885	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AC028_11890	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
AC028_11895	COG0732	type I restriction modification DNA specificity domain
AC028_11900	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AC028_11925	COG0328	RNA-DNA hybrid ribonuclease activity
AC028_11925	COG0406	alpha-ribazole phosphatase activity
AC028_11930	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AC028_11945	COG3387	PFAM Glycoside hydrolase 15-related
AC028_11950	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_11955	COG3537	Alpha-1,2-mannosidase
AC028_11960	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_11975	COG0492	ferredoxin-NADP+ reductase activity
AC028_12000	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC028_12005	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AC028_12010	COG2080	2 iron, 2 sulfur cluster binding
AC028_12045	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC028_12065	COG0587	DNA-directed DNA polymerase activity
AC028_12080	COG1297	OPT oligopeptide transporter protein
AC028_12095	COG0823	Involved in the tonB-independent uptake of proteins
AC028_12095	COG1506	peptidase
AC028_12115	COG2207	Transcriptional regulator
AC028_12115	COG1917	Cupin 2, conserved barrel domain protein
AC028_12130	COG0753	catalase activity
AC028_12135	COG0656	L-ascorbic acid biosynthetic process
AC028_12145	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC028_12145	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC028_12150	COG2814	Major facilitator Superfamily
AC028_12165	COG2194	sulfuric ester hydrolase activity
AC028_12180	COG0745	RESPONSE REGULATOR receiver
AC028_12185	COG0642	Histidine kinase
AC028_12195	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AC028_12200	COG2894	cell division
AC028_12205	COG0850	regulation of cytokinetic process
AC028_12215	COG4585	Histidine kinase
AC028_12220	COG2197	response regulator
AC028_12235	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AC028_12260	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AC028_12270	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AC028_12290	COG1946	Acyl-CoA thioesterase
AC028_12305	COG0824	Thioesterase
AC028_12310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AC028_12315	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AC028_12320	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AC028_12325	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AC028_12330	COG0268	Binds directly to 16S ribosomal RNA
AC028_12340	COG0196	riboflavin kinase activity
AC028_12345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AC028_12350	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AC028_12355	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AC028_12390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AC028_12395	COG1845	cytochrome c oxidase, subunit III
AC028_12400	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AC028_12415	COG3152	Membrane
AC028_12425	COG2207	Transcriptional regulator
AC028_12430	COG0326	Molecular chaperone. Has ATPase activity
AC028_12440	COG1366	Belongs to the anti-sigma-factor antagonist family
AC028_12445	COG1366	Belongs to the anti-sigma-factor antagonist family
AC028_12450	COG2172	sigma factor antagonist activity
AC028_12475	COG4771	TonB-dependent receptor
AC028_12485	COG5507	3-demethylubiquinone-9 3-methyltransferase
AC028_12495	COG2205	protein histidine kinase activity
AC028_12505	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AC028_12510	COG2205	protein histidine kinase activity
AC028_12510	COG3850	Histidine kinase
AC028_12510	COG4999	Histidine kinase
AC028_12510	COG3437	response regulator, receiver
AC028_12515	COG4191	Histidine kinase
AC028_12515	COG0784	Response regulator, receiver
AC028_12545	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AC028_12550	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AC028_12565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AC028_12570	COG0228	four-way junction DNA binding
AC028_12575	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AC028_12580	COG0336	Belongs to the RNA methyltransferase TrmD family
AC028_12585	COG0335	large ribosomal subunit rRNA binding
AC028_12590	COG0534	Mate efflux family protein
AC028_12615	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AC028_12625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AC028_12635	COG3483	tryptophan 2,3-dioxygenase activity
AC028_12675	COG3250	beta-galactosidase activity
AC028_12680	COG3867	Arabinogalactan endo-beta-1,4-galactanase
AC028_12700	COG1960	acyl-CoA dehydrogenase activity
AC028_12705	COG1024	Enoyl-CoA hydratase
AC028_12725	COG2801	Transposase and inactivated derivatives
AC028_12730	COG2963	transposase activity
AC028_12750	COG3039	Transposase
AC028_12755	COG3039	Transposase
AC028_12775	COG2755	lipolytic protein G-D-S-L family
AC028_12775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AC028_12780	COG4221	oxidoreductase activity
AC028_12795	COG0018	arginyl-trna synthetase
AC028_12800	COG2003	Belongs to the UPF0758 family
AC028_12805	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AC028_12810	COG0756	dUTP diphosphatase activity
AC028_12830	COG0463	Glycosyl transferase, family 2
AC028_12850	COG1475	DNA binding
AC028_12855	COG1192	Involved in chromosome partitioning
AC028_12865	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AC028_12870	COG0708	Exodeoxyribonuclease III
AC028_12875	COG2223	nitrite transmembrane transporter activity
AC028_12885	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AC028_12890	COG0739	heme binding
AC028_12895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AC028_12935	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AC028_12950	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AC028_12980	COG0109	protoheme IX farnesyltransferase activity
AC028_12995	COG0358	DNA primase activity
AC028_13000	COG1295	ribonuclease BN
AC028_13005	COG1610	YqeY-like protein
AC028_13010	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AC028_13015	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AC028_13020	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AC028_13030	COG2133	pyrroloquinoline quinone binding
AC028_13035	COG4682	membrane
AC028_13050	COG0531	amino acid
AC028_13060	COG4948	Mandelate Racemase Muconate Lactonizing
AC028_13070	COG3023	N-Acetylmuramoyl-L-alanine amidase
AC028_13075	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AC028_13120	COG5383	Protein conserved in bacteria
AC028_13140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC028_13145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC028_13150	COG1473	amidohydrolase
AC028_13155	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AC028_13155	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AC028_13180	COG0583	DNA-binding transcription factor activity
AC028_13185	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AC028_13190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AC028_13195	COG3118	belongs to the thioredoxin family
AC028_13200	COG0513	Belongs to the DEAD box helicase family
AC028_13205	COG2884	Cell division ATP-binding protein ftsE
AC028_13210	COG2177	Part of the ABC transporter FtsEX involved in
AC028_13215	COG2201	protein-glutamate methylesterase activity
AC028_13220	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AC028_13225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AC028_13230	COG2860	membrane
AC028_13235	COG1252	NADH dehydrogenase
AC028_13250	COG0625	glutathione transferase activity
AC028_13275	COG0534	Mate efflux family protein
AC028_13280	COG0616	signal peptide processing
AC028_13295	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_13310	COG0009	L-threonylcarbamoyladenylate synthase
AC028_13315	COG1754	DNA topoisomerase type I activity
AC028_13315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AC028_13335	COG0758	DNA mediated transformation
AC028_13340	COG1652	LysM domain
AC028_13345	COG0242	peptide deformylase activity
AC028_13350	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AC028_13355	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AC028_13355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC028_13405	COG1560	Kdo2-lipid A biosynthetic process
AC028_13410	COG1490	D-aminoacyl-tRNA deacylase activity
AC028_13415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AC028_13480	COG2963	transposase activity
AC028_13485	COG2801	Transposase and inactivated derivatives
AC028_13565	COG0840	transmembrane signaling receptor activity
AC028_13580	COG0251	oxidation-reduction process
AC028_13655	COG1063	alcohol dehydrogenase
AC028_13670	COG1132	(ABC) transporter
AC028_13690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AC028_13695	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_13710	COG1294	oxidase, subunit
AC028_13715	COG1271	oxidase subunit
AC028_13725	COG2204	response regulator
AC028_13760	COG3546	catalase activity
AC028_13765	COG3685	Protein conserved in bacteria
AC028_13780	COG2972	Histidine kinase
AC028_13795	COG0531	amino acid
AC028_13810	COG3590	peptidase
AC028_13820	COG0667	Aldo Keto reductase
AC028_13830	COG0583	DNA-binding transcription factor activity
AC028_13840	COG3384	dioxygenase
AC028_13850	COG1573	uracil-dna glycosylase
AC028_13855	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AC028_13860	COG0025	NhaP-type Na H and K H
AC028_13865	COG1131	(ABC) transporter
AC028_13870	COG0842	Transport permease protein
AC028_13920	COG1522	sequence-specific DNA binding
AC028_13925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC028_13930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AC028_13950	COG2202	Pas domain
AC028_13950	COG2205	protein histidine kinase activity
AC028_13970	COG2813	Specifically methylates the guanine in position
AC028_13975	COG1187	pseudouridine synthase activity
AC028_13980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AC028_14005	COG0784	Response regulator, receiver
AC028_14005	COG5002	protein histidine kinase activity
AC028_14005	COG2198	Histidine kinase
AC028_14015	COG1666	GTP binding
AC028_14020	COG0697	spore germination
AC028_14025	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AC028_14030	COG2011	ABC-type metal ion transport system permease component
AC028_14055	COG3039	Transposase
AC028_14075	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC028_14085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC028_14105	COG0356	it plays a direct role in the translocation of protons across the membrane
AC028_14115	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AC028_14120	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AC028_14125	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AC028_14130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AC028_14135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AC028_14140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AC028_14160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AC028_14165	COG4191	Histidine kinase
AC028_14170	COG2204	response regulator
AC028_14180	COG1136	(ABC) transporter
AC028_14180	COG0577	efflux transmembrane transporter activity
AC028_14185	COG0577	efflux transmembrane transporter activity
AC028_14190	COG3039	Transposase
AC028_14195	COG1136	(ABC) transporter
AC028_14200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC028_14205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AC028_14240	COG2132	Multicopper oxidase
AC028_14255	COG0339	signal peptide processing
AC028_14270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC028_14275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AC028_14280	COG0546	phosphoglycolate phosphatase activity
AC028_14290	COG2819	hydrolase of the alpha beta superfamily
AC028_14300	COG1956	GAF domain-containing protein
AC028_14305	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AC028_14335	COG0720	synthase
AC028_14340	COG4771	TonB-dependent receptor
AC028_14350	COG0513	Belongs to the DEAD box helicase family
AC028_14360	COG0625	glutathione transferase activity
AC028_14390	COG0626	cystathionine gamma-synthase activity
AC028_14400	COG0438	transferase activity, transferring glycosyl groups
AC028_14425	COG0438	transferase activity, transferring glycosyl groups
AC028_14430	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AC028_14445	COG2963	transposase activity
AC028_14455	COG2801	Transposase and inactivated derivatives
AC028_14460	COG2963	transposase activity
AC028_14485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC028_14495	COG0277	FAD linked oxidase domain protein
AC028_14500	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AC028_14500	COG0546	phosphoglycolate phosphatase activity
AC028_14515	COG2086	electron transfer activity
AC028_14545	COG0662	Cupin 2, conserved barrel domain protein
AC028_14545	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AC028_14550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC028_14580	COG3218	ABC-type transport auxiliary lipoprotein component
AC028_14580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AC028_14585	COG1127	ABC transporter
AC028_14590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AC028_14625	COG1131	(ABC) transporter
AC028_14630	COG0346	lactoylglutathione lyase activity
AC028_14635	COG0833	amino acid
AC028_14640	COG2040	homocysteine
AC028_14650	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AC028_14670	COG1695	Transcriptional regulator
AC028_14705	COG0825	malonyl-CoA metabolic process
AC028_14720	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC028_14725	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC028_14730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC028_14735	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC028_14750	COG0750	zinc metalloprotease
AC028_14755	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AC028_14760	COG0575	Belongs to the CDS family
AC028_14765	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AC028_14770	COG0233	cytoplasmic translational termination
AC028_14775	COG0528	UMP kinase activity
AC028_14780	COG0745	RESPONSE REGULATOR receiver
AC028_14780	COG3706	GGDEF domain
AC028_14785	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AC028_14790	COG0052	Belongs to the universal ribosomal protein uS2 family
AC028_14825	COG0024	Methionine aminopeptidase
AC028_14830	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AC028_14840	COG1393	Belongs to the ArsC family
AC028_14845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC028_14850	COG0367	asparagine synthase
AC028_14860	COG4774	siderophore transport
AC028_14875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AC028_14900	COG1566	PFAM secretion protein HlyD family protein
AC028_14905	COG2814	Major facilitator Superfamily
AC028_14955	COG0339	signal peptide processing
AC028_14960	COG0386	Belongs to the glutathione peroxidase family
AC028_15015	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AC028_15020	COG0084	hydrolase, TatD family'
AC028_15035	COG1960	acyl-CoA dehydrogenase activity
AC028_15055	COG0367	asparagine synthase
AC028_15065	COG0305	Participates in initiation and elongation during chromosome replication
AC028_15070	COG0415	Belongs to the DNA photolyase family
AC028_15080	COG0583	DNA-binding transcription factor activity
AC028_15115	COG3706	GGDEF domain
AC028_15150	COG0322	excinuclease ABC activity
AC028_15155	COG1484	DNA-dependent DNA replication
AC028_15160	COG4584	PFAM Integrase catalytic
AC028_15190	COG3039	Transposase
AC028_15200	COG1595	DNA-templated transcription, initiation
AC028_15205	COG3712	iron ion homeostasis
AC028_15230	COG4206	TonB-dependent receptor
AC028_15245	COG3039	Transposase
AC028_15260	COG3039	Transposase
AC028_15270	COG1162	GTPase activity
AC028_15295	COG2211	Major facilitator Superfamily
AC028_15300	COG1609	Transcriptional regulator
AC028_15305	COG3039	Transposase
AC028_15310	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_15315	COG2851	Citrate transporter
AC028_15330	COG0642	Histidine kinase
AC028_15335	COG1840	ABC-type Fe3 transport system, periplasmic component
AC028_15340	COG2197	response regulator
AC028_15355	COG0667	Aldo Keto reductase
AC028_15365	COG0583	DNA-binding transcription factor activity
AC028_15390	COG1301	dicarboxylic acid transport
AC028_15395	COG0281	malic enzyme
AC028_15395	COG0280	phosphate acetyltransferase
AC028_15425	COG2801	Transposase and inactivated derivatives
AC028_15430	COG2963	transposase activity
AC028_15450	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AC028_15465	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC028_15475	COG0497	DNA recombination
AC028_15480	COG1420	regulation of RNA biosynthetic process
AC028_15485	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AC028_15490	COG0443	Heat shock 70 kDa protein
AC028_15495	COG0484	heat shock protein binding
AC028_15500	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AC028_15530	COG0583	DNA-binding transcription factor activity
AC028_15535	COG1132	(ABC) transporter
AC028_15550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC028_15560	COG0567	Dehydrogenase, E1 component
AC028_15570	COG2850	peptidyl-arginine hydroxylation
AC028_15605	COG1253	flavin adenine dinucleotide binding
AC028_15610	COG0114	fumarate hydratase activity
AC028_15635	COG1131	(ABC) transporter
AC028_15640	COG1725	Transcriptional regulator
AC028_15645	COG0386	Belongs to the glutathione peroxidase family
AC028_15660	COG2900	Belongs to the SlyX family
AC028_15685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC028_15695	COG0646	methionine synthase
AC028_15695	COG1410	methionine synthase
AC028_15700	COG0646	methionine synthase
AC028_15700	COG1410	methionine synthase
AC028_15710	COG1960	acyl-CoA dehydrogenase activity
AC028_15715	COG1960	acyl-CoA dehydrogenase activity
AC028_15720	COG1960	acyl-CoA dehydrogenase activity
AC028_15725	COG1960	acyl-CoA dehydrogenase activity
AC028_15730	COG1960	acyl-CoA dehydrogenase activity
AC028_15735	COG1960	acyl-CoA dehydrogenase activity
AC028_15740	COG1960	acyl-CoA dehydrogenase activity
AC028_15745	COG1960	acyl-CoA dehydrogenase activity
AC028_15750	COG1960	acyl-CoA dehydrogenase activity
AC028_15765	COG0557	exoribonuclease II activity
AC028_15785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC028_15790	COG3706	GGDEF domain
AC028_15795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AC028_15805	COG0704	Plays a role in the regulation of phosphate uptake
AC028_15810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AC028_15815	COG0581	inorganic phosphate transmembrane transporter activity
AC028_15820	COG0573	inorganic phosphate transmembrane transporter activity
AC028_15825	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AC028_15850	COG0659	secondary active sulfate transmembrane transporter activity
AC028_15855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AC028_15865	COG1024	Enoyl-CoA hydratase
AC028_15875	COG0494	nUDIX hydrolase
AC028_15915	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AC028_15915	COG0116	Belongs to the methyltransferase superfamily
AC028_15920	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AC028_15940	COG2925	Exonuclease
AC028_15945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC028_15950	COG3844	kynureninase activity
AC028_15960	COG0662	Cupin 2, conserved barrel domain protein
AC028_15965	COG0288	reversible hydration of carbon dioxide
AC028_16050	COG0017	Asparaginyl-tRNA synthetase
AC028_16055	COG0316	Belongs to the HesB IscA family
AC028_16060	COG0360	Binds together with S18 to 16S ribosomal RNA
AC028_16065	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AC028_16070	COG0359	binds to the 23S rRNA
AC028_16085	COG3115	cell septum assembly
AC028_16100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AC028_16105	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AC028_16115	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AC028_16125	COG4993	Dehydrogenase
AC028_16135	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AC028_16145	COG2986	histidine ammonia-lyase
AC028_16150	COG1228	amidohydrolase
AC028_16190	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AC028_16195	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AC028_16200	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AC028_16205	COG0077	Prephenate dehydratase
AC028_16205	COG1605	Chorismate mutase
AC028_16210	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AC028_16225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AC028_16230	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AC028_16235	COG0583	DNA-binding transcription factor activity
AC028_16250	COG0840	transmembrane signaling receptor activity
AC028_16280	COG5002	protein histidine kinase activity
AC028_16280	COG2205	protein histidine kinase activity
AC028_16280	COG0784	Response regulator, receiver
AC028_16285	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AC028_16290	COG0784	Response regulator, receiver
AC028_16290	COG4191	Histidine kinase
AC028_16305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC028_16315	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AC028_16325	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AC028_16340	COG1595	DNA-templated transcription, initiation
AC028_16390	COG2244	polysaccharide biosynthetic process
AC028_16420	COG2264	protein methyltransferase activity
AC028_16445	COG1136	(ABC) transporter
AC028_16455	COG0477	Major facilitator Superfamily
AC028_16460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC028_16475	COG1253	flavin adenine dinucleotide binding
AC028_16485	COG0306	phosphate transporter
AC028_16510	COG0504	CTP synthase activity
AC028_16525	COG0148	phosphopyruvate hydratase activity
AC028_16530	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AC028_16535	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AC028_16540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AC028_16545	COG0585	pseudouridine synthase activity
AC028_16550	COG2840	Smr protein MutS2
AC028_16555	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AC028_16560	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AC028_16565	COG1238	metal cluster binding
AC028_16580	COG1534	Rna-binding protein
AC028_16585	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AC028_16590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AC028_16595	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AC028_16600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AC028_16605	COG1923	regulation of RNA biosynthetic process
AC028_16610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AC028_16615	COG1546	Belongs to the CinA family
AC028_16625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC028_16630	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AC028_16635	COG2137	regulation of response to DNA damage stimulus
AC028_16640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AC028_16645	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AC028_16660	COG1741	Belongs to the pirin family
AC028_16670	COG0583	DNA-binding transcription factor activity
AC028_16695	COG0351	phosphomethylpyrimidine kinase
AC028_16710	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AC028_16715	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AC028_16730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC028_16740	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AC028_16745	COG3734	2-keto-3-deoxy-galactonokinase
AC028_16755	COG4948	Mandelate Racemase Muconate Lactonizing
AC028_16760	COG0800	Aldolase
AC028_16800	COG1501	Belongs to the glycosyl hydrolase 31 family
AC028_16810	COG1070	Carbohydrate kinase
AC028_16815	COG2115	Belongs to the xylose isomerase family
AC028_16820	COG0477	Major facilitator Superfamily
AC028_16845	COG1469	GTP cyclohydrolase I activity
AC028_16865	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AC028_16870	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AC028_16875	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AC028_16900	COG1472	Belongs to the glycosyl hydrolase 3 family
AC028_16910	COG3706	GGDEF domain
AC028_16910	COG5001	Diguanylate cyclase
AC028_16910	COG4251	negative regulation of phosphorylation
AC028_16910	COG2203	Gaf domain
AC028_16915	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC028_16920	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AC028_16930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AC028_16935	COG0671	phosphoesterase, PA-phosphatase related
AC028_16945	COG1794	racemase activity, acting on amino acids and derivatives
AC028_16950	COG0697	spore germination
AC028_16955	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AC028_16960	COG0167	dihydroorotate dehydrogenase activity
AC028_16975	COG1012	belongs to the aldehyde dehydrogenase family
AC028_16985	COG3039	Transposase
AC028_16990	COG2963	transposase activity
AC028_16995	COG2801	Transposase and inactivated derivatives
AC028_17020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AC028_17030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC028_17035	COG0124	histidyl-tRNA synthetase
AC028_17045	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AC028_17050	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AC028_17055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC028_17060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AC028_17060	COG0131	Imidazoleglycerol-phosphate dehydratase
AC028_17065	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AC028_17070	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AC028_17075	COG0107	imidazoleglycerol-phosphate synthase activity
AC028_17080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AC028_17080	COG0140	phosphoribosyl-ATP diphosphatase activity
AC028_17100	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AC028_17105	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AC028_17110	COG0235	Class ii aldolase
AC028_17115	COG0531	amino acid
AC028_17120	COG0531	amino acid
AC028_17130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AC028_17135	COG0277	FAD linked oxidase domain protein
AC028_17155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AC028_17200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC028_17205	COG2258	MOSC domain
AC028_17210	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AC028_17215	COG0505	Belongs to the CarA family
AC028_17225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AC028_17230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC028_17240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AC028_17250	COG3279	Response regulator of the LytR AlgR family
AC028_17255	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AC028_17260	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AC028_17275	COG0784	Response regulator, receiver
AC028_17275	COG2198	Histidine kinase
AC028_17275	COG2205	protein histidine kinase activity
AC028_17280	COG1024	Enoyl-CoA hydratase
AC028_17320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC028_17330	COG2201	protein-glutamate methylesterase activity
AC028_17335	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AC028_17345	COG0840	transmembrane signaling receptor activity
AC028_17355	COG0835	chemotaxis
AC028_17365	COG0840	transmembrane signaling receptor activity
AC028_17370	COG0840	transmembrane signaling receptor activity
AC028_17375	COG0840	transmembrane signaling receptor activity
AC028_17380	COG0840	transmembrane signaling receptor activity
AC028_17385	COG0840	transmembrane signaling receptor activity
AC028_17395	COG0840	transmembrane signaling receptor activity
AC028_17410	COG0840	transmembrane signaling receptor activity
AC028_17420	COG0840	transmembrane signaling receptor activity
AC028_17425	COG0840	transmembrane signaling receptor activity
AC028_17425	COG0840	transmembrane signaling receptor activity
AC028_17440	COG0840	transmembrane signaling receptor activity
AC028_17450	COG0745	RESPONSE REGULATOR receiver
AC028_17460	COG0835	chemotaxis
AC028_17465	COG1192	Involved in chromosome partitioning
AC028_17470	COG1360	Flagellar Motor Protein
AC028_17475	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AC028_17545	COG0643	Histidine kinase
AC028_17545	COG2198	Histidine kinase
AC028_17565	COG0455	bacterial-type flagellum organization
AC028_17590	COG3300	MHYT domain
AC028_17590	COG5001	Diguanylate cyclase
AC028_17605	COG1684	flagellar biosynthetic protein fliR
AC028_17610	COG1987	bacterial-type flagellum assembly
AC028_17625	COG3190	flagellar
AC028_17675	COG1677	Flagellar hook-basal body complex protein FliE
AC028_17735	COG3039	Transposase
AC028_17745	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_17750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC028_17765	COG2204	response regulator
AC028_17770	COG2201	protein-glutamate methylesterase activity
AC028_17800	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AC028_17810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AC028_17820	COG3951	Flagellar rod assembly protein muramidase FlgJ
AC028_17820	COG1705	Flagellar rod assembly protein muramidase FlgJ
AC028_17825	COG1706	bacterial-type flagellum-dependent cell motility
AC028_17830	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AC028_17835	COG4786	Flagellar basal body rod
AC028_17840	COG4787	bacterial-type flagellum-dependent cell motility
AC028_17845	COG1749	Flagellar hook protein flgE
AC028_17850	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AC028_17855	COG1558	bacterial-type flagellum-dependent cell motility
AC028_17865	COG0835	chemotaxis
AC028_17865	COG0784	Response regulator, receiver
AC028_17885	COG5002	protein histidine kinase activity
AC028_17915	COG2915	High frequency lysogenization protein hflD homolog
AC028_17920	COG0482	sulfurtransferase activity
AC028_17930	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AC028_17935	COG0542	response to heat
AC028_17940	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AC028_17945	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AC028_17955	COG0492	ferredoxin-NADP+ reductase activity
AC028_17960	COG1674	ftsk spoiiie
AC028_17970	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AC028_17980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AC028_17985	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AC028_17990	COG0183	Belongs to the thiolase family
AC028_17995	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC028_17995	COG1024	Enoyl-CoA hydratase
AC028_18005	COG0105	UTP biosynthetic process
AC028_18010	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AC028_18020	COG1426	Protein conserved in bacteria
AC028_18030	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC028_18035	COG1160	GTP binding
AC028_18040	COG0303	'Molybdopterin
AC028_18045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AC028_18080	COG0708	Exodeoxyribonuclease III
AC028_18090	COG0303	'Molybdopterin
AC028_18095	COG0746	molybdenum cofactor guanylyltransferase activity
AC028_18125	COG1914	H( )-stimulated, divalent metal cation uptake system
AC028_18130	COG1321	iron dependent repressor
AC028_18135	COG0590	tRNA wobble adenosine to inosine editing
AC028_18140	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AC028_18145	COG0668	transmembrane transport
AC028_18155	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AC028_18170	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_18175	COG1183	phosphatidylcholine synthase activity
AC028_18185	COG3243	poly(R)-hydroxyalkanoic acid synthase
AC028_18200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC028_18200	COG0723	plastoquinol--plastocyanin reductase activity
AC028_18210	COG2183	response to ionizing radiation
AC028_18285	COG0800	Aldolase
AC028_18290	COG0129	dihydroxy-acid dehydratase activity
AC028_18295	COG0363	glucosamine-6-phosphate deaminase activity
AC028_18300	COG0837	glucose binding
AC028_18305	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AC028_18315	COG0354	folic acid binding
AC028_18325	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AC028_18340	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AC028_18345	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AC028_18355	COG4591	ABC-type transport system involved in lipoprotein release permease component
AC028_18360	COG1136	(ABC) transporter
AC028_18375	COG0811	peptide transport
AC028_18380	COG0848	biopolymer transport protein
AC028_18385	COG1132	(ABC) transporter
AC028_18390	COG1663	tetraacyldisaccharide 4'-kinase activity
AC028_18395	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AC028_18400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AC028_18425	COG0322	excinuclease ABC activity
AC028_18430	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AC028_18455	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AC028_18495	COG3064	Membrane
AC028_18500	COG0428	transporter
AC028_18510	COG2154	pterin-4-alpha-carbinolamine dehydratase
AC028_18515	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AC028_18515	COG0316	Belongs to the HesB IscA family
AC028_18535	COG2951	lytic endotransglycosylase activity
AC028_18540	COG4644	lycopene metabolic process
AC028_18570	COG3920	Histidine kinase
AC028_18585	COG3039	Transposase
AC028_18605	COG0583	DNA-binding transcription factor activity
AC028_18615	COG2963	transposase activity
AC028_18640	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_18645	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AC028_18650	COG1073	alpha beta
AC028_18650	COG2226	methyltransferase
AC028_18690	COG5001	Diguanylate cyclase
AC028_18710	COG3685	Protein conserved in bacteria
AC028_18725	COG1648	precorrin-2 dehydrogenase activity
AC028_18725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AC028_18740	COG2814	Major facilitator Superfamily
AC028_18755	COG1335	isochorismatase
AC028_18795	COG0583	DNA-binding transcription factor activity
AC028_18800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC028_18805	COG3002	Belongs to the UPF0753 family
AC028_18860	COG0582	viral genome integration into host DNA
AC028_18865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AC028_18865	COG0519	Catalyzes the synthesis of GMP from XMP
AC028_18875	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AC028_18885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AC028_18885	COG0475	glutathione-regulated potassium exporter activity
AC028_18890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AC028_18900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AC028_18905	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AC028_18915	COG0776	regulation of translation
AC028_18920	COG0539	negative regulation of cytoplasmic translation
AC028_18930	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AC028_18940	COG2957	Belongs to the agmatine deiminase family
AC028_18945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC028_18970	COG0395	ABC-type sugar transport system, permease component
AC028_19005	COG2350	Protein conserved in bacteria
AC028_19010	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AC028_19015	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AC028_19020	COG1187	pseudouridine synthase activity
AC028_19035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC028_19040	COG0436	Aminotransferase
AC028_19045	COG4133	protoheme IX ABC transporter activity
AC028_19065	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AC028_19070	COG1138	Cytochrome C-type biogenesis protein
AC028_19090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC028_19095	COG1278	Cold shock
AC028_19100	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AC028_19105	COG4988	ABC transporter
AC028_19115	COG1294	oxidase, subunit
AC028_19145	COG1476	TRANSCRIPTIONal
AC028_19150	COG0464	growth
AC028_19255	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AC028_19260	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AC028_19270	COG0165	Argininosuccinate lyase
AC028_19275	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AC028_19285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AC028_19300	COG0137	argininosuccinate synthase activity
AC028_19305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AC028_19315	COG0215	cysteine-tRNA ligase activity
AC028_19320	COG2166	iron-sulfur cluster assembly
AC028_19330	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AC028_19340	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AC028_19345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC028_19365	COG4302	ethanolamine ammonia-lyase activity
AC028_19415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AC028_19420	COG0402	S-adenosylhomocysteine deaminase activity
AC028_19430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AC028_19435	COG1509	lysine 2,3-aminomutase activity
AC028_19440	COG3300	MHYT domain
AC028_19440	COG5001	Diguanylate cyclase
AC028_19455	COG0483	inositol monophosphate 1-phosphatase activity
AC028_19480	COG0513	Belongs to the DEAD box helicase family
AC028_19485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AC028_19490	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AC028_19500	COG0625	glutathione transferase activity
AC028_19510	COG4681	YaeQ
AC028_19515	COG2081	HI0933 family
AC028_19525	COG0501	Belongs to the peptidase M48B family
AC028_19530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC028_19535	COG1028	Short-chain dehydrogenase reductase Sdr
AC028_19560	COG0860	N-Acetylmuramoyl-L-alanine amidase
AC028_19565	COG0802	atpase or kinase
AC028_19570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AC028_19570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AC028_19575	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AC028_19580	COG1570	exodeoxyribonuclease VII activity
AC028_19590	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AC028_19630	COG0835	chemotaxis
AC028_19635	COG0840	transmembrane signaling receptor activity
AC028_19640	COG2094	Belongs to the DNA glycosylase MPG family
AC028_19645	COG1201	RNA secondary structure unwinding
AC028_19660	COG2969	positive regulation of protein catabolic process
AC028_19665	COG0625	glutathione transferase activity
AC028_19670	COG2857	Cytochrome c1
AC028_19675	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AC028_19680	COG0723	plastoquinol--plastocyanin reductase activity
AC028_19685	COG0741	lytic transglycosylase activity
AC028_19700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AC028_19705	COG1702	phosphate starvation-inducible protein PhoH
AC028_19715	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AC028_19725	COG4535	Mg2 and Co2 transporter CorC
AC028_19740	COG1012	belongs to the aldehyde dehydrogenase family
AC028_19750	COG1177	transmembrane transport
AC028_19755	COG1176	ABC-type spermidine putrescine transport system, permease component I
AC028_19760	COG3842	ATPase activity
AC028_19780	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AC028_19795	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AC028_19800	COG0174	glutamine synthetase
AC028_19805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC028_19810	COG0745	RESPONSE REGULATOR receiver
AC028_19810	COG3706	GGDEF domain
AC028_19815	COG2703	oxygen carrier activity
AC028_19820	COG0477	Major facilitator Superfamily
AC028_19835	COG0243	molybdopterin cofactor binding
AC028_19840	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AC028_19860	COG2733	membrane
AC028_19865	COG2205	protein histidine kinase activity
AC028_19865	COG0784	Response regulator, receiver
AC028_19865	COG5002	protein histidine kinase activity
AC028_19875	COG0477	Major facilitator Superfamily
AC028_19905	COG2902	Dehydrogenase
AC028_19915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC028_19920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC028_19925	COG1609	Transcriptional regulator
AC028_19930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AC028_19930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC028_19935	COG1105	Belongs to the carbohydrate kinase PfkB family
AC028_19940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AC028_19940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AC028_19945	COG2801	Transposase and inactivated derivatives
AC028_19950	COG2963	transposase activity
AC028_19965	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AC028_19975	COG1862	Preprotein translocase
AC028_19980	COG0343	queuine tRNA-ribosyltransferase activity
AC028_19985	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AC028_20025	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AC028_20040	COG3291	Pkd domain containing protein
AC028_20050	COG0405	Gamma-glutamyltransferase
AC028_20055	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AC028_20070	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AC028_20075	COG0742	ribosomal rna small subunit methyltransferase
AC028_20080	COG0326	Molecular chaperone. Has ATPase activity
AC028_20110	COG3039	Transposase
AC028_20180	COG0531	amino acid
AC028_20195	COG0006	proline dipeptidase activity
AC028_20205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC028_20220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC028_20225	COG3938	Belongs to the proline racemase family
AC028_20235	COG0552	protein localization to endoplasmic reticulum
AC028_20240	COG1194	a g-specific adenine glycosylase
AC028_20245	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AC028_20250	COG0784	Response regulator, receiver
AC028_20250	COG4191	Histidine kinase
AC028_20265	COG0322	excinuclease ABC activity
AC028_20280	COG3040	lipid binding
AC028_20290	COG1960	acyl-CoA dehydrogenase activity
AC028_20300	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AC028_20320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC028_20325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC028_20330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC028_20365	COG0438	transferase activity, transferring glycosyl groups
AC028_20370	COG0438	transferase activity, transferring glycosyl groups
AC028_20415	COG0776	regulation of translation
AC028_20420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC028_20420	COG0072	phenylalanine-tRNA ligase activity
AC028_20425	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AC028_20430	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AC028_20435	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AC028_20440	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AC028_20445	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AC028_20490	COG3505	Type IV secretory pathway VirD4
AC028_20505	COG0556	nucleotide-excision repair
AC028_20515	COG3039	Transposase
AC028_20520	COG2801	Transposase and inactivated derivatives
AC028_20525	COG2963	transposase activity
AC028_20560	COG4969	Belongs to the N-Me-Phe pilin family
AC028_20565	COG1611	Belongs to the LOG family
AC028_20575	COG2095	MarC family integral membrane protein
AC028_20585	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AC028_20590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AC028_20620	COG1185	polyribonucleotide nucleotidyltransferase activity
AC028_20625	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AC028_20630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AC028_20635	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AC028_20640	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AC028_20645	COG0195	Participates in both transcription termination and antitermination
AC028_20650	COG0779	Required for maturation of 30S ribosomal subunits
AC028_20660	COG1007	ATP synthesis coupled electron transport
AC028_20675	COG0713	ATP synthesis coupled electron transport
AC028_20685	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC028_20690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AC028_20700	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AC028_20705	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AC028_20710	COG0649	NAD binding
AC028_20715	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC028_20720	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC028_20725	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC028_20740	COG0149	triose-phosphate isomerase activity
AC028_20745	COG0300	oxidoreductase activity
AC028_20750	COG3039	Transposase
AC028_20785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC028_20790	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AC028_20795	COG0159	tryptophan synthase activity
AC028_20805	COG0133	tryptophan synthase activity
AC028_20815	COG0135	phosphoribosylanthranilate isomerase activity
AC028_20820	COG0101	tRNA pseudouridine synthase activity
AC028_20840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AC028_20845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC028_20850	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AC028_20855	COG2890	protein-(glutamine-N5) methyltransferase activity
AC028_20865	COG0688	phosphatidylethanolamine metabolic process
AC028_20875	COG0433	COG0433 Predicted ATPase
AC028_20880	COG0494	nUDIX hydrolase
AC028_20895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC028_20900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AC028_20925	COG0717	Belongs to the dCTP deaminase family
AC028_20930	COG0489	protein tyrosine kinase activity
AC028_20950	COG3590	peptidase
AC028_20955	COG3590	peptidase
AC028_20975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC028_20980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC028_20985	COG2311	Membrane
AC028_20990	COG1047	Peptidyl-prolyl cis-trans
AC028_20995	COG0791	NLP P60 protein
AC028_21000	COG0791	NLP P60 protein
AC028_21010	COG4106	trans-aconitate 2-methyltransferase activity
AC028_21015	COG1301	dicarboxylic acid transport
AC028_21020	COG1785	Belongs to the alkaline phosphatase family
AC028_21025	COG0037	tRNA processing
AC028_21030	COG1722	exodeoxyribonuclease VII activity
AC028_21035	COG0142	geranyltranstransferase activity
AC028_21050	COG0312	modulator of DNA gyrase
AC028_21055	COG3028	Belongs to the UPF0307 family
AC028_21060	COG0312	modulator of DNA gyrase
AC028_21070	COG3164	Protein of unknown function
AC028_21075	COG1530	ribonuclease E activity
AC028_21080	COG0424	maF-like protein
AC028_21085	COG2968	Membrane
AC028_21100	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AC028_21115	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AC028_21130	COG0495	leucyl-tRNA aminoacylation
AC028_21140	COG3118	belongs to the thioredoxin family
AC028_21175	COG2155	Conserved Protein
AC028_21180	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AC028_21220	COG1132	(ABC) transporter
AC028_21250	COG0735	belongs to the Fur family
AC028_21255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC028_21280	COG4452	Inner membrane protein CreD
AC028_21295	COG2205	protein histidine kinase activity
AC028_21300	COG0745	RESPONSE REGULATOR receiver
AC028_21305	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AC028_21320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AC028_21330	COG0643	Histidine kinase
AC028_21330	COG2198	Histidine kinase
AC028_21335	COG0840	transmembrane signaling receptor activity
AC028_21340	COG0835	chemotaxis
AC028_21380	COG3012	SEC-C Motif Domain Protein
AC028_21380	COG3318	Belongs to the UPF0149 family
AC028_21400	COG3077	Addiction module antitoxin, RelB DinJ family
AC028_21405	COG3041	Addiction module toxin RelE StbE family
AC028_21465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC028_21485	COG2948	multi-organism process
AC028_21490	COG3504	Conjugal transfer protein
AC028_21500	COG3704	protein secretion by the type IV secretion system
AC028_21550	COG1192	Involved in chromosome partitioning