locus-tag	class	description
TP37_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TP37_00015	COG2963	transposase activity
TP37_00020	COG2801	Transposase and inactivated derivatives
TP37_00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TP37_00030	COG0187	DNA topoisomerase II activity
TP37_00040	COG0501	Belongs to the peptidase M48B family
TP37_00075	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TP37_00085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP37_00130	COG0793	Belongs to the peptidase S41A family
TP37_00135	COG4942	peptidase
TP37_00145	COG2234	aminopeptidase activity
TP37_00160	COG1064	alcohol dehydrogenase
TP37_00165	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TP37_00175	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TP37_00190	COG2801	Transposase and inactivated derivatives
TP37_00215	COG0493	'glutamate synthase
TP37_00220	COG0067	glutamate synthase
TP37_00220	COG0070	glutamate synthase
TP37_00220	COG0069	glutamate synthase activity
TP37_00305	COG1205	dead DEAH box helicase
TP37_00305	COG1111	helicase
TP37_00310	COG1272	protein, Hemolysin III
TP37_00325	COG0300	oxidoreductase activity
TP37_00330	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_00355	COG2963	transposase activity
TP37_00360	COG2801	Transposase and inactivated derivatives
TP37_00390	COG0714	Associated with various cellular activities
TP37_00435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TP37_00490	COG3237	CsbD-like
TP37_00505	COG2801	Transposase and inactivated derivatives
TP37_00510	COG2963	transposase activity
TP37_00520	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TP37_00530	COG4772	TonB-dependent receptor
TP37_00545	COG1012	belongs to the aldehyde dehydrogenase family
TP37_00570	COG1304	FMN binding
TP37_00580	COG4585	Histidine kinase
TP37_00585	COG2197	response regulator
TP37_00605	COG3710	Transcriptional regulator
TP37_00610	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TP37_00650	COG3039	Transposase
TP37_00655	COG3039	Transposase
TP37_00665	COG2801	Transposase and inactivated derivatives
TP37_00670	COG2963	transposase activity
TP37_00675	COG3039	Transposase
TP37_00695	COG0366	Alpha amylase catalytic
TP37_00700	COG0366	Alpha amylase catalytic
TP37_00705	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TP37_00735	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TP37_00750	COG3507	Belongs to the glycosyl hydrolase 43 family
TP37_00755	COG1609	Transcriptional regulator
TP37_00760	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TP37_00765	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_00775	COG2755	lipolytic protein G-D-S-L family
TP37_00785	COG3186	Phenylalanine-4-hydroxylase
TP37_00790	COG1522	sequence-specific DNA binding
TP37_00800	COG1752	Esterase of the alpha-beta hydrolase superfamily
TP37_00810	COG1119	ATPase activity
TP37_00825	COG1125	glycine betaine transport
TP37_00825	COG0517	IMP dehydrogenase activity
TP37_00840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TP37_00880	COG0489	protein tyrosine kinase activity
TP37_00885	COG2062	phosphohistidine phosphatase, SixA
TP37_00895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP37_00940	COG1968	undecaprenyl-diphosphatase activity
TP37_00945	COG0174	glutamine synthetase
TP37_00950	COG0347	Belongs to the P(II) protein family
TP37_00955	COG0004	ammonium transporteR
TP37_00960	COG3852	Histidine kinase
TP37_00965	COG2204	response regulator
TP37_00970	COG2032	superoxide dismutase activity
TP37_00975	COG2032	superoxide dismutase activity
TP37_00980	COG0346	lactoylglutathione lyase activity
TP37_00990	COG0183	Belongs to the thiolase family
TP37_01025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TP37_01030	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TP37_01035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TP37_01055	COG0028	Belongs to the TPP enzyme family
TP37_01060	COG2205	protein histidine kinase activity
TP37_01085	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TP37_01100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TP37_01110	COG0596	Alpha beta hydrolase
TP37_01120	COG0318	PFAM AMP-dependent synthetase and ligase
TP37_01135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TP37_01155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TP37_01165	COG0564	pseudouridine synthase activity
TP37_01190	COG0339	signal peptide processing
TP37_01225	COG0475	glutathione-regulated potassium exporter activity
TP37_01230	COG0583	DNA-binding transcription factor activity
TP37_01235	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TP37_01240	COG2224	Isocitrate lyase
TP37_01245	COG3706	GGDEF domain
TP37_01275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TP37_01280	COG1960	acyl-CoA dehydrogenase activity
TP37_01350	COG0697	spore germination
TP37_01360	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TP37_01365	COG1846	Transcriptional regulator
TP37_01370	COG1764	response to oxidative stress
TP37_01400	COG2130	NADP-dependent
TP37_01415	COG1187	pseudouridine synthase activity
TP37_01430	COG1643	Atp-dependent helicase
TP37_01435	COG4807	Protein conserved in bacteria
TP37_01440	COG2351	hydroxyisourate hydrolase activity
TP37_01445	COG2072	flavoprotein involved in K transport
TP37_01465	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TP37_01475	COG0583	DNA-binding transcription factor activity
TP37_01510	COG2252	PERMEase
TP37_01530	COG0084	hydrolase, TatD family'
TP37_01540	COG0583	DNA-binding transcription factor activity
TP37_01545	COG2814	Major facilitator Superfamily
TP37_01555	COG2267	carboxylic ester hydrolase activity
TP37_01560	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TP37_01565	COG1902	pentaerythritol trinitrate reductase activity
TP37_01585	COG0745	RESPONSE REGULATOR receiver
TP37_01595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP37_01615	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TP37_01620	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TP37_01625	COG0583	DNA-binding transcription factor activity
TP37_01660	COG0702	epimerase
TP37_01665	COG1733	regulation of RNA biosynthetic process
TP37_01700	COG2963	transposase activity
TP37_01705	COG2801	Transposase and inactivated derivatives
TP37_01720	COG0129	dihydroxy-acid dehydratase activity
TP37_01740	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TP37_01795	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TP37_01800	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TP37_01825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TP37_01830	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TP37_01840	COG3485	protocatechuate 3,4-dioxygenase
TP37_01845	COG3485	protocatechuate 3,4-dioxygenase
TP37_01860	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TP37_01870	COG1414	Transcriptional regulator
TP37_01895	COG0445	tRNA wobble uridine modification
TP37_01930	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_01935	COG2267	carboxylic ester hydrolase activity
TP37_01945	COG0156	8-amino-7-oxononanoate synthase activity
TP37_01950	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TP37_01955	COG1040	competence protein
TP37_01960	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TP37_01970	COG0582	viral genome integration into host DNA
TP37_01980	COG2963	transposase activity
TP37_01985	COG2801	Transposase and inactivated derivatives
TP37_02030	COG5297	Belongs to the glycosyl hydrolase family 6
TP37_02085	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TP37_02135	COG3039	Transposase
TP37_02160	COG3039	Transposase
TP37_02170	COG3264	Mechanosensitive ion channel
TP37_02170	COG1511	domain protein
TP37_02175	COG1368	sulfuric ester hydrolase activity
TP37_02180	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TP37_02185	COG2354	Protein conserved in bacteria
TP37_02190	COG3706	GGDEF domain
TP37_02190	COG0745	RESPONSE REGULATOR receiver
TP37_02195	COG0297	glycogen (starch) synthase activity
TP37_02200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TP37_02205	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TP37_02230	COG0702	epimerase
TP37_02235	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_02270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP37_02275	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_02285	COG0513	Belongs to the DEAD box helicase family
TP37_02290	COG0508	dehydrogenase complex catalyzes the overall conversion of
TP37_02305	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TP37_02315	COG3483	tryptophan 2,3-dioxygenase activity
TP37_02320	COG3104	oligopeptide transport
TP37_02340	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
TP37_02355	COG1320	monovalent cation:proton antiporter activity
TP37_02360	COG2212	antiporter activity
TP37_02370	COG0651	ATP synthesis coupled electron transport
TP37_02375	COG1006	Multisubunit Na H antiporter MnhC subunit
TP37_02380	COG2111	Na H antiporter
TP37_02380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TP37_02405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TP37_02410	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TP37_02430	COG1597	lipid kinase activity
TP37_02455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TP37_02460	COG0134	indole-3-glycerol-phosphate synthase activity
TP37_02470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TP37_02475	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TP37_02485	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TP37_02490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TP37_02495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TP37_02510	COG1051	belongs to the nudix hydrolase family
TP37_02550	COG0316	Belongs to the HesB IscA family
TP37_02565	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TP37_02580	COG2814	Major facilitator Superfamily
TP37_02590	COG2814	Major facilitator Superfamily
TP37_02595	COG1289	transmembrane transporter activity
TP37_02605	COG0151	Belongs to the GarS family
TP37_02615	COG0138	bifunctional purine biosynthesis protein purh
TP37_02620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TP37_02625	COG2267	carboxylic ester hydrolase activity
TP37_02630	COG2453	phosphatase
TP37_02630	COG0671	phosphoesterase, PA-phosphatase related
TP37_02655	COG4589	Belongs to the CDS family
TP37_02660	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
TP37_02685	COG2264	protein methyltransferase activity
TP37_02700	COG0439	Biotin carboxylase
TP37_02710	COG0511	ligase activity, forming carbon-carbon bonds
TP37_02715	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TP37_02725	COG1324	tolerance protein
TP37_02730	COG2356	endonuclease I
TP37_02735	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TP37_02740	COG0459	protein refolding
TP37_02755	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TP37_02770	COG3386	PFAM SMP-30 Gluconolaconase
TP37_02780	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TP37_02795	COG3039	Transposase
TP37_02810	COG3039	Transposase
TP37_02840	COG0778	Nitroreductase
TP37_02845	COG2353	YceI-like domain
TP37_02875	COG3052	prosthetic group binding
TP37_02895	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
TP37_02910	COG1802	Transcriptional regulator
TP37_02945	COG3039	Transposase
TP37_02970	COG2963	transposase activity
TP37_02975	COG2801	Transposase and inactivated derivatives
TP37_02980	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
TP37_02985	COG0025	NhaP-type Na H and K H
TP37_02990	COG1131	(ABC) transporter
TP37_02995	COG0842	Transport permease protein
TP37_03045	COG1522	sequence-specific DNA binding
TP37_03050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP37_03055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TP37_03075	COG2202	Pas domain
TP37_03075	COG2205	protein histidine kinase activity
TP37_03095	COG2813	Specifically methylates the guanine in position
TP37_03100	COG1187	pseudouridine synthase activity
TP37_03105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TP37_03140	COG1666	GTP binding
TP37_03145	COG0697	spore germination
TP37_03150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TP37_03155	COG2011	ABC-type metal ion transport system permease component
TP37_03200	COG0508	dehydrogenase complex catalyzes the overall conversion of
TP37_03210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TP37_03230	COG0356	it plays a direct role in the translocation of protons across the membrane
TP37_03240	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TP37_03245	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TP37_03250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TP37_03255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TP37_03260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TP37_03265	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TP37_03285	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TP37_03290	COG4191	Histidine kinase
TP37_03295	COG2204	response regulator
TP37_03305	COG1136	(ABC) transporter
TP37_03305	COG0577	efflux transmembrane transporter activity
TP37_03310	COG0577	efflux transmembrane transporter activity
TP37_03315	COG1136	(ABC) transporter
TP37_03320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP37_03325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TP37_03360	COG2132	Multicopper oxidase
TP37_03375	COG0339	signal peptide processing
TP37_03380	COG3039	Transposase
TP37_03395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TP37_03400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TP37_03405	COG0546	phosphoglycolate phosphatase activity
TP37_03415	COG2819	hydrolase of the alpha beta superfamily
TP37_03425	COG1956	GAF domain-containing protein
TP37_03435	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TP37_03465	COG0720	synthase
TP37_03470	COG4771	TonB-dependent receptor
TP37_03490	COG0513	Belongs to the DEAD box helicase family
TP37_03500	COG0625	glutathione transferase activity
TP37_03530	COG0626	cystathionine gamma-synthase activity
TP37_03540	COG0438	transferase activity, transferring glycosyl groups
TP37_03560	COG0438	transferase activity, transferring glycosyl groups
TP37_03565	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TP37_03595	COG0582	viral genome integration into host DNA
TP37_03605	COG3039	Transposase
TP37_03610	COG5295	Hep Hag repeat protein
TP37_03615	COG1404	Belongs to the peptidase S8 family
TP37_03635	COG1404	Belongs to the peptidase S8 family
TP37_03640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TP37_03645	COG1459	type II secretion system
TP37_03650	COG2165	general secretion pathway protein
TP37_03655	COG4970	Tfp pilus assembly protein FimT
TP37_03660	COG2165	general secretion pathway protein
TP37_03665	COG4795	General secretion pathway protein
TP37_03670	COG3156	type II secretion system protein K
TP37_03675	COG3166	PFAM Fimbrial assembly family protein
TP37_03690	COG1450	Type ii and iii secretion system protein
TP37_03700	COG2188	Transcriptional regulator
TP37_03750	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TP37_03780	COG1215	transferase activity, transferring glycosyl groups
TP37_03785	COG1215	transferase activity, transferring glycosyl groups
TP37_03790	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
TP37_03795	COG0457	Tetratricopeptide repeat
TP37_03820	COG0242	peptide deformylase activity
TP37_03825	COG1307	EDD domain protein, DegV family
TP37_03845	COG0402	S-adenosylhomocysteine deaminase activity
TP37_03850	COG3964	amidohydrolase
TP37_03865	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TP37_03870	COG0726	polysaccharide deacetylase
TP37_03885	COG0436	Aminotransferase
TP37_03905	COG3039	Transposase
TP37_03915	COG1162	GTPase activity
TP37_03940	COG2211	Major facilitator Superfamily
TP37_03945	COG1609	Transcriptional regulator
TP37_03950	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_03955	COG2851	Citrate transporter
TP37_03970	COG0642	Histidine kinase
TP37_03975	COG1840	ABC-type Fe3 transport system, periplasmic component
TP37_03980	COG2197	response regulator
TP37_03995	COG0667	Aldo Keto reductase
TP37_04005	COG0583	DNA-binding transcription factor activity
TP37_04030	COG1301	dicarboxylic acid transport
TP37_04035	COG0281	malic enzyme
TP37_04035	COG0280	phosphate acetyltransferase
TP37_04060	COG1560	Kdo2-lipid A biosynthetic process
TP37_04065	COG1519	Transferase
TP37_04070	COG1538	Outer membrane efflux protein
TP37_04075	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TP37_04095	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TP37_04100	COG0066	3-isopropylmalate dehydratase activity
TP37_04105	COG0473	3-isopropylmalate dehydrogenase activity
TP37_04120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TP37_04140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TP37_04145	COG0405	Gamma-glutamyltransferase
TP37_04150	COG0840	transmembrane signaling receptor activity
TP37_04160	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TP37_04165	COG3710	Transcriptional regulator
TP37_04185	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TP37_04195	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TP37_04210	COG0563	adenylate kinase activity
TP37_04215	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TP37_04225	COG3781	membrane
TP37_04230	COG0671	phosphoesterase, PA-phosphatase related
TP37_04240	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_04245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TP37_04250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TP37_04280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TP37_04295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TP37_04305	COG0352	thiamine-phosphate diphosphorylase activity
TP37_04310	COG1773	rubredoxin
TP37_04315	COG2912	Transglutaminase-like superfamily
TP37_04325	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TP37_04335	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TP37_04350	COG3079	Belongs to the UPF0149 family
TP37_04355	COG0006	proline dipeptidase activity
TP37_04360	COG0006	proline dipeptidase activity
TP37_04375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TP37_04380	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TP37_04390	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TP37_04395	COG1561	YicC-like family, N-terminal region
TP37_04405	COG1758	RNA polymerase activity
TP37_04410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TP37_04445	COG2721	sulfolactate sulfo-lyase activity
TP37_04455	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TP37_04465	COG0254	rRNA binding
TP37_04480	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TP37_04515	COG0714	Associated with various cellular activities
TP37_04535	COG2304	oxidoreductase activity
TP37_04545	COG1301	dicarboxylic acid transport
TP37_04550	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TP37_04590	COG0739	heme binding
TP37_04595	COG1376	ErfK ybiS ycfS ynhG family protein
TP37_04630	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TP37_04635	COG4149	molybdate abc transporter
TP37_04640	COG0725	ABC transporter, periplasmic molybdate-binding protein
TP37_04645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TP37_04645	COG3453	Protein conserved in bacteria
TP37_04655	COG3047	cAMP biosynthetic process
TP37_04660	COG3047	cAMP biosynthetic process
TP37_04670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TP37_04690	COG0126	phosphoglycerate kinase activity
TP37_04700	COG0469	pyruvate kinase activity
TP37_04705	COG3588	fructose-bisphosphate aldolase
TP37_04710	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TP37_04760	COG0175	sulfate reduction
TP37_04765	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TP37_04770	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TP37_04775	COG0175	sulfate reduction
TP37_04780	COG2895	sulfate adenylyltransferase (ATP) activity
TP37_04780	COG0529	Catalyzes the synthesis of activated sulfate
TP37_04785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP37_04790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP37_04795	COG0308	aminopeptidase N
TP37_04805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TP37_04815	COG4948	Mandelate Racemase Muconate Lactonizing
TP37_04820	COG3250	beta-galactosidase activity
TP37_04830	COG1609	Transcriptional regulator
TP37_04840	COG1970	mechanosensitive ion channel activity
TP37_04865	COG3273	potassium ion transport
TP37_04865	COG0471	metal ion transport
TP37_04870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TP37_04875	COG2022	thiamine diphosphate biosynthetic process
TP37_04920	COG3039	Transposase
TP37_04935	COG3039	Transposase
TP37_05025	COG2801	Transposase and inactivated derivatives
TP37_05030	COG2963	transposase activity
TP37_05055	COG1074	ATP-dependent DNA helicase activity
TP37_05145	COG2801	Transposase and inactivated derivatives
TP37_05240	COG0745	RESPONSE REGULATOR receiver
TP37_05250	COG2801	Transposase and inactivated derivatives
TP37_05255	COG2963	transposase activity
TP37_05290	COG0237	dephospho-CoA kinase activity
TP37_05295	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TP37_05300	COG1459	type II secretion system
TP37_05335	COG0045	succinate-CoA ligase (ADP-forming) activity
TP37_05340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TP37_05355	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TP37_05355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TP37_05365	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TP37_05370	COG0564	pseudouridine synthase activity
TP37_05385	COG3011	Protein conserved in bacteria
TP37_05390	COG0840	transmembrane signaling receptor activity
TP37_05405	COG3387	PFAM Glycoside hydrolase 15-related
TP37_05410	COG1877	trehalose-phosphatase activity
TP37_05450	COG2827	Endonuclease containing a URI domain
TP37_05455	COG4771	TonB-dependent receptor
TP37_05465	COG0667	Aldo Keto reductase
TP37_05470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TP37_05475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TP37_05480	COG1116	anion transmembrane transporter activity
TP37_05485	COG0542	response to heat
TP37_05495	COG4206	TonB-dependent receptor
TP37_05515	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TP37_05525	COG1492	cobalamin metabolic process
TP37_05545	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TP37_05570	COG2963	transposase activity
TP37_05575	COG2801	Transposase and inactivated derivatives
TP37_05600	COG0019	diaminopimelate decarboxylase activity
TP37_05615	COG4264	IucA IucC family
TP37_05625	COG4772	TonB-dependent receptor
TP37_05635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TP37_05635	COG4651	solute:proton antiporter activity
TP37_05665	COG0488	(ABC) transporter
TP37_05700	COG0477	Major facilitator Superfamily
TP37_05715	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TP37_05730	COG0217	transcriptional regulatory protein
TP37_05735	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TP37_05740	COG0632	four-way junction helicase activity
TP37_05745	COG3158	transport of potassium into the cell
TP37_05750	COG2255	four-way junction helicase activity
TP37_05755	COG0824	Thioesterase
TP37_05765	COG0848	biopolymer transport protein
TP37_05775	COG0823	Involved in the tonB-independent uptake of proteins
TP37_05780	COG2885	chlorophyll binding
TP37_05790	COG0602	queuosine metabolic process
TP37_05805	COG3920	Histidine kinase
TP37_05825	COG0840	transmembrane signaling receptor activity
TP37_05885	COG0514	ATP-dependent DNA helicase (RecQ)
TP37_05890	COG0783	Belongs to the Dps family
TP37_05895	COG1643	Atp-dependent helicase
TP37_05905	COG0837	glucose binding
TP37_05920	COG0535	radical SAM domain protein
TP37_05925	COG0535	radical SAM domain protein
TP37_05930	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
TP37_05935	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TP37_05940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TP37_05950	COG1215	transferase activity, transferring glycosyl groups
TP37_05955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TP37_05965	COG1199	ATP-dependent helicase activity
TP37_05975	COG1397	ADP-ribosylglycohydrolase
TP37_05985	COG0189	ligase activity
TP37_06000	COG0835	chemotaxis
TP37_06005	COG0840	transmembrane signaling receptor activity
TP37_06035	COG1446	asparaginase
TP37_06040	COG3142	Participates in the control of copper homeostasis
TP37_06090	COG3537	Alpha-1,2-mannosidase
TP37_06100	COG1486	melibiose metabolic process
TP37_06110	COG0531	amino acid
TP37_06125	COG1472	Belongs to the glycosyl hydrolase 3 family
TP37_06135	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TP37_06140	COG3858	chitin binding
TP37_06140	COG1388	LysM domain
TP37_06155	COG0837	glucose binding
TP37_06160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TP37_06170	COG0494	nUDIX hydrolase
TP37_06175	COG1218	3'(2'),5'-bisphosphate nucleotidase
TP37_06180	COG3956	TIGRFAM MazG family protein
TP37_06185	COG1742	UPF0060 membrane protein
TP37_06195	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TP37_06200	COG0509	glycine decarboxylation via glycine cleavage system
TP37_06225	COG1960	acyl-CoA dehydrogenase activity
TP37_06230	COG2267	carboxylic ester hydrolase activity
TP37_06235	COG1309	transcriptional regulator
TP37_06245	COG4771	TonB-dependent receptor
TP37_06255	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TP37_06260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TP37_06270	COG0516	GMP reductase activity
TP37_06270	COG0517	IMP dehydrogenase activity
TP37_06275	COG2982	Protein involved in outer membrane biogenesis
TP37_06280	COG1272	protein, Hemolysin III
TP37_06285	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TP37_06290	COG0739	heme binding
TP37_06295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TP37_06300	COG0626	cystathionine gamma-synthase activity
TP37_06305	COG0527	aspartate kinase activity
TP37_06305	COG0460	homoserine dehydrogenase
TP37_06320	COG1760	l-serine dehydratase
TP37_06340	COG2353	YceI-like domain
TP37_06345	COG2205	protein histidine kinase activity
TP37_06345	COG0784	Response regulator, receiver
TP37_06345	COG2198	Histidine kinase
TP37_06360	COG3039	Transposase
TP37_06375	COG0477	Major facilitator Superfamily
TP37_06380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TP37_06390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TP37_06395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TP37_06400	COG0259	pyridoxamine-phosphate oxidase activity
TP37_06410	COG1842	Phage shock protein A
TP37_06435	COG0754	glutathionylspermidine amidase activity
TP37_06445	COG2814	Major facilitator Superfamily
TP37_06520	COG0531	amino acid
TP37_06525	COG2197	response regulator
TP37_06560	COG1113	amino acid transport
TP37_06570	COG1271	oxidase subunit
TP37_06575	COG1294	oxidase, subunit
TP37_06585	COG2239	Acts as a magnesium transporter
TP37_06590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TP37_06595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TP37_06605	COG1660	Displays ATPase and GTPase activities
TP37_06610	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TP37_06615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TP37_06630	COG1137	ATPase activity
TP37_06635	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
TP37_06645	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TP37_06655	COG0271	Belongs to the BolA IbaG family
TP37_06660	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TP37_06680	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TP37_06690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TP37_06700	COG0628	permease
TP37_06710	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TP37_06715	COG3178	'Phosphotransferase
TP37_06730	COG1555	photosystem II stabilization
TP37_06750	COG1250	3-hydroxyacyl-CoA dehydrogenase
TP37_06750	COG1024	Enoyl-CoA hydratase
TP37_06765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TP37_06770	COG0481	GTPase activity
TP37_06785	COG0571	ribonuclease III activity
TP37_06790	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TP37_06795	COG1381	Involved in DNA repair and RecF pathway recombination
TP37_06805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TP37_06810	COG3039	Transposase
TP37_06820	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TP37_06825	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
TP37_06835	COG1472	Belongs to the glycosyl hydrolase 3 family
TP37_06845	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TP37_06850	COG1278	Cold shock
TP37_06855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TP37_06865	COG1201	RNA secondary structure unwinding
TP37_06870	COG1793	dna ligase
TP37_06880	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TP37_06880	COG1793	dna ligase
TP37_06895	COG3706	GGDEF domain
TP37_06895	COG0745	RESPONSE REGULATOR receiver
TP37_06910	COG0183	Belongs to the thiolase family
TP37_06925	COG1451	nucleotide metabolic process
TP37_06930	COG5487	UPF0391 membrane protein
TP37_06940	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TP37_06965	COG1047	Peptidyl-prolyl cis-trans
TP37_06975	COG2824	Alkylphosphonate utilization operon protein PhnA
TP37_06980	COG1902	pentaerythritol trinitrate reductase activity
TP37_06985	COG2814	Major facilitator Superfamily
TP37_07020	COG0392	lysyltransferase activity
TP37_07020	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TP37_07030	COG0251	oxidation-reduction process
TP37_07035	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TP37_07050	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TP37_07075	COG1595	DNA-templated transcription, initiation
TP37_07120	COG5449	Phage conserved hypothetical protein BR0599
TP37_07185	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TP37_07185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TP37_07200	COG1131	(ABC) transporter
TP37_07205	COG0346	lactoylglutathione lyase activity
TP37_07210	COG0833	amino acid
TP37_07215	COG2040	homocysteine
TP37_07225	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
TP37_07285	COG4584	PFAM Integrase catalytic
TP37_07300	COG0825	malonyl-CoA metabolic process
TP37_07315	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TP37_07320	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TP37_07325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TP37_07330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TP37_07345	COG0750	zinc metalloprotease
TP37_07350	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TP37_07355	COG0575	Belongs to the CDS family
TP37_07360	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TP37_07365	COG0233	cytoplasmic translational termination
TP37_07370	COG0528	UMP kinase activity
TP37_07375	COG3706	GGDEF domain
TP37_07375	COG0745	RESPONSE REGULATOR receiver
TP37_07380	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TP37_07385	COG0052	Belongs to the universal ribosomal protein uS2 family
TP37_07430	COG3039	Transposase
TP37_07435	COG0024	Methionine aminopeptidase
TP37_07440	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TP37_07450	COG1393	Belongs to the ArsC family
TP37_07455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TP37_07460	COG0367	asparagine synthase
TP37_07470	COG4774	siderophore transport
TP37_07485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TP37_07510	COG1566	PFAM secretion protein HlyD family protein
TP37_07515	COG2814	Major facilitator Superfamily
TP37_07535	COG3104	oligopeptide transport
TP37_07565	COG0339	signal peptide processing
TP37_07570	COG0386	Belongs to the glutathione peroxidase family
TP37_07585	COG3039	Transposase
TP37_07640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TP37_07645	COG0084	hydrolase, TatD family'
TP37_07660	COG1960	acyl-CoA dehydrogenase activity
TP37_07680	COG0367	asparagine synthase
TP37_07690	COG0305	Participates in initiation and elongation during chromosome replication
TP37_07695	COG0415	Belongs to the DNA photolyase family
TP37_07705	COG0583	DNA-binding transcription factor activity
TP37_07740	COG3706	GGDEF domain
TP37_07750	COG3706	GGDEF domain
TP37_07830	COG3039	Transposase
TP37_07850	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TP37_07890	COG5002	protein histidine kinase activity
TP37_07890	COG5001	Diguanylate cyclase
TP37_07895	COG1187	pseudouridine synthase activity
TP37_07900	COG0745	RESPONSE REGULATOR receiver
TP37_07900	COG3706	GGDEF domain
TP37_07920	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TP37_07925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TP37_07930	COG0475	glutathione-regulated potassium exporter activity
TP37_07935	COG5002	protein histidine kinase activity
TP37_07935	COG5000	phosphorelay sensor kinase activity
TP37_07940	COG0745	RESPONSE REGULATOR receiver
TP37_07945	COG1538	Outer membrane efflux protein
TP37_07970	COG1132	(ABC) transporter
TP37_08005	COG3039	Transposase
TP37_08020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TP37_08025	COG2155	Conserved Protein
TP37_08050	COG3039	Transposase
TP37_08055	COG3039	Transposase
TP37_08080	COG2963	transposase activity
TP37_08085	COG2801	Transposase and inactivated derivatives
TP37_08115	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TP37_08125	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TP37_08130	COG3039	Transposase
TP37_08135	COG0745	RESPONSE REGULATOR receiver
TP37_08140	COG2205	protein histidine kinase activity
TP37_08155	COG4452	Inner membrane protein CreD
TP37_08180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TP37_08185	COG0735	belongs to the Fur family
TP37_08200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP37_08205	COG1538	Outer membrane efflux protein
TP37_08210	COG1309	transcriptional regulator
TP37_08220	COG2207	Transcriptional regulator
TP37_08230	COG0583	DNA-binding transcription factor activity
TP37_08235	COG2814	Major facilitator Superfamily
TP37_08240	COG0667	Aldo Keto reductase
TP37_08260	COG2963	transposase activity
TP37_08265	COG2801	Transposase and inactivated derivatives
TP37_08300	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TP37_08315	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TP37_08325	COG0497	DNA recombination
TP37_08330	COG1420	regulation of RNA biosynthetic process
TP37_08335	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TP37_08340	COG0443	Heat shock 70 kDa protein
TP37_08345	COG0484	heat shock protein binding
TP37_08350	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
TP37_08385	COG0583	DNA-binding transcription factor activity
TP37_08390	COG1132	(ABC) transporter
TP37_08425	COG2850	peptidyl-arginine hydroxylation
TP37_08450	COG1253	flavin adenine dinucleotide binding
TP37_08480	COG1131	(ABC) transporter
TP37_08485	COG1725	Transcriptional regulator
TP37_08490	COG0386	Belongs to the glutathione peroxidase family
TP37_08505	COG2900	Belongs to the SlyX family
TP37_08545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TP37_08555	COG0646	methionine synthase
TP37_08555	COG1410	methionine synthase
TP37_08560	COG1410	methionine synthase
TP37_08560	COG0646	methionine synthase
TP37_08570	COG1960	acyl-CoA dehydrogenase activity
TP37_08575	COG1960	acyl-CoA dehydrogenase activity
TP37_08590	COG0557	exoribonuclease II activity
TP37_08600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TP37_08605	COG3706	GGDEF domain
TP37_08610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TP37_08620	COG0704	Plays a role in the regulation of phosphate uptake
TP37_08625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TP37_08630	COG0581	inorganic phosphate transmembrane transporter activity
TP37_08635	COG0573	inorganic phosphate transmembrane transporter activity
TP37_08640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TP37_08665	COG0659	secondary active sulfate transmembrane transporter activity
TP37_08670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TP37_08680	COG1024	Enoyl-CoA hydratase
TP37_08690	COG0494	nUDIX hydrolase
TP37_08730	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TP37_08730	COG0116	Belongs to the methyltransferase superfamily
TP37_08735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TP37_08755	COG2925	Exonuclease
TP37_08760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TP37_08765	COG3844	kynureninase activity
TP37_08775	COG0662	Cupin 2, conserved barrel domain protein
TP37_08780	COG0288	reversible hydration of carbon dioxide
TP37_08875	COG0017	Asparaginyl-tRNA synthetase
TP37_08880	COG0316	Belongs to the HesB IscA family
TP37_08885	COG0360	Binds together with S18 to 16S ribosomal RNA
TP37_08890	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TP37_08895	COG0359	binds to the 23S rRNA
TP37_08910	COG3115	cell septum assembly
TP37_08920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TP37_08925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TP37_08930	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TP37_08940	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TP37_08950	COG4993	Dehydrogenase
TP37_08960	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TP37_08970	COG2986	histidine ammonia-lyase
TP37_08975	COG1228	amidohydrolase
TP37_09015	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
TP37_09025	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TP37_09030	COG1605	Chorismate mutase
TP37_09030	COG0077	Prephenate dehydratase
TP37_09035	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TP37_09055	COG3920	Histidine kinase
TP37_09070	COG3220	belongs to the UPF0276 family
TP37_09115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TP37_09145	COG4644	lycopene metabolic process
TP37_09150	COG2951	lytic endotransglycosylase activity
TP37_09165	COG2801	Transposase and inactivated derivatives
TP37_09330	COG2963	transposase activity
TP37_09335	COG2801	Transposase and inactivated derivatives
TP37_09390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TP37_09390	COG0519	Catalyzes the synthesis of GMP from XMP
TP37_09400	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TP37_09420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TP37_09420	COG0475	glutathione-regulated potassium exporter activity
TP37_09425	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TP37_09435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TP37_09440	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
TP37_09450	COG0776	regulation of translation
TP37_09455	COG0539	negative regulation of cytoplasmic translation
TP37_09460	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TP37_09465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TP37_09475	COG2957	Belongs to the agmatine deiminase family
TP37_09480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TP37_09505	COG0395	ABC-type sugar transport system, permease component
TP37_09510	COG1175	transmembrane transport
TP37_09540	COG2350	Protein conserved in bacteria
TP37_09545	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TP37_09550	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TP37_09555	COG1187	pseudouridine synthase activity
TP37_09595	COG1012	belongs to the aldehyde dehydrogenase family
TP37_09610	COG0167	dihydroorotate dehydrogenase activity
TP37_09615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TP37_09620	COG0697	spore germination
TP37_09625	COG1794	racemase activity, acting on amino acids and derivatives
TP37_09635	COG0671	phosphoesterase, PA-phosphatase related
TP37_09640	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TP37_09650	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TP37_09655	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TP37_09670	COG5001	Diguanylate cyclase
TP37_09670	COG2203	Gaf domain
TP37_09670	COG3706	GGDEF domain
TP37_09670	COG4251	negative regulation of phosphorylation
TP37_09680	COG1472	Belongs to the glycosyl hydrolase 3 family
TP37_09705	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TP37_09710	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TP37_09715	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TP37_09735	COG1469	GTP cyclohydrolase I activity
TP37_09740	COG0860	N-Acetylmuramoyl-L-alanine amidase
TP37_09745	COG3039	Transposase
TP37_09750	COG3039	Transposase
TP37_09770	COG0477	Major facilitator Superfamily
TP37_09775	COG2115	Belongs to the xylose isomerase family
TP37_09780	COG1070	Carbohydrate kinase
TP37_09790	COG1501	Belongs to the glycosyl hydrolase 31 family
TP37_09830	COG0800	Aldolase
TP37_09835	COG4948	Mandelate Racemase Muconate Lactonizing
TP37_09845	COG3734	2-keto-3-deoxy-galactonokinase
TP37_09850	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TP37_09860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TP37_09875	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TP37_09880	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TP37_09895	COG0351	phosphomethylpyrimidine kinase
TP37_09945	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TP37_09950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TP37_09955	COG2137	regulation of response to DNA damage stimulus
TP37_09960	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TP37_09965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TP37_09975	COG1546	Belongs to the CinA family
TP37_09980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TP37_09985	COG1923	regulation of RNA biosynthetic process
TP37_09990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TP37_09995	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TP37_10000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TP37_10005	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TP37_10010	COG1534	Rna-binding protein
TP37_10025	COG1238	metal cluster binding
TP37_10030	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TP37_10035	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TP37_10040	COG2840	Smr protein MutS2
TP37_10045	COG0585	pseudouridine synthase activity
TP37_10050	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TP37_10055	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TP37_10060	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TP37_10065	COG0148	phosphopyruvate hydratase activity
TP37_10080	COG0504	CTP synthase activity
TP37_10085	COG3039	Transposase
TP37_10110	COG2801	Transposase and inactivated derivatives
TP37_10115	COG2963	transposase activity
TP37_10130	COG0306	phosphate transporter
TP37_10140	COG1253	flavin adenine dinucleotide binding
TP37_10155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TP37_10160	COG0477	Major facilitator Superfamily
TP37_10170	COG1136	(ABC) transporter
TP37_10195	COG2264	protein methyltransferase activity
TP37_10225	COG2244	polysaccharide biosynthetic process
TP37_10275	COG1595	DNA-templated transcription, initiation
TP37_10290	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TP37_10300	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TP37_10310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TP37_10325	COG4191	Histidine kinase
TP37_10325	COG0784	Response regulator, receiver
TP37_10330	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TP37_10335	COG0784	Response regulator, receiver
TP37_10335	COG5002	protein histidine kinase activity
TP37_10335	COG2205	protein histidine kinase activity
TP37_10370	COG2801	Transposase and inactivated derivatives
TP37_10375	COG2963	transposase activity
TP37_10405	COG0583	DNA-binding transcription factor activity
TP37_10425	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TP37_10440	COG1238	metal cluster binding
TP37_10485	COG3279	Response regulator of the LytR AlgR family
TP37_10490	COG3275	phosphorelay sensor kinase activity
TP37_10540	COG4566	intracellular signal transduction
TP37_10565	COG1648	precorrin-2 dehydrogenase activity
TP37_10565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TP37_10580	COG2814	Major facilitator Superfamily
TP37_10595	COG1335	isochorismatase
TP37_10625	COG2197	response regulator
TP37_10655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TP37_10660	COG3002	Belongs to the UPF0753 family
TP37_10720	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_10735	COG3039	Transposase
TP37_10740	COG2801	Transposase and inactivated derivatives
TP37_10745	COG2963	transposase activity
TP37_10765	COG0316	Belongs to the HesB IscA family
TP37_10765	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TP37_10770	COG2154	pterin-4-alpha-carbinolamine dehydratase
TP37_10780	COG0428	transporter
TP37_10785	COG3064	Membrane
TP37_10795	COG1530	ribonuclease E activity
TP37_10820	COG3039	Transposase
TP37_10835	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TP37_10860	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TP37_10865	COG0322	excinuclease ABC activity
TP37_10880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TP37_10885	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TP37_10890	COG1663	tetraacyldisaccharide 4'-kinase activity
TP37_10895	COG1132	(ABC) transporter
TP37_10905	COG0811	peptide transport
TP37_10920	COG1136	(ABC) transporter
TP37_10925	COG4591	ABC-type transport system involved in lipoprotein release permease component
TP37_10935	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
TP37_10940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TP37_10955	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TP37_10965	COG0354	folic acid binding
TP37_10975	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TP37_10980	COG0837	glucose binding
TP37_10985	COG0363	glucosamine-6-phosphate deaminase activity
TP37_10990	COG0129	dihydroxy-acid dehydratase activity
TP37_10995	COG0800	Aldolase
TP37_11090	COG2183	response to ionizing radiation
TP37_11100	COG0723	plastoquinol--plastocyanin reductase activity
TP37_11100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP37_11115	COG3243	poly(R)-hydroxyalkanoic acid synthase
TP37_11125	COG1183	phosphatidylcholine synthase activity
TP37_11130	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_11145	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TP37_11155	COG0668	transmembrane transport
TP37_11165	COG0590	tRNA wobble adenosine to inosine editing
TP37_11170	COG1321	iron dependent repressor
TP37_11175	COG1914	H( )-stimulated, divalent metal cation uptake system
TP37_11190	COG2072	flavoprotein involved in K transport
TP37_11210	COG0746	molybdenum cofactor guanylyltransferase activity
TP37_11215	COG0303	'Molybdopterin
TP37_11225	COG0708	Exodeoxyribonuclease III
TP37_11270	COG0303	'Molybdopterin
TP37_11275	COG1160	GTP binding
TP37_11280	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TP37_11290	COG1426	Protein conserved in bacteria
TP37_11305	COG0105	UTP biosynthetic process
TP37_11315	COG1024	Enoyl-CoA hydratase
TP37_11315	COG1250	3-hydroxyacyl-CoA dehydrogenase
TP37_11320	COG0183	Belongs to the thiolase family
TP37_11325	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TP37_11330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TP37_11340	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TP37_11350	COG1674	ftsk spoiiie
TP37_11355	COG0492	ferredoxin-NADP+ reductase activity
TP37_11365	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TP37_11370	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TP37_11375	COG0542	response to heat
TP37_11380	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TP37_11390	COG0482	sulfurtransferase activity
TP37_11395	COG2915	High frequency lysogenization protein hflD homolog
TP37_11435	COG5002	protein histidine kinase activity
TP37_11455	COG0835	chemotaxis
TP37_11455	COG0784	Response regulator, receiver
TP37_11465	COG1558	bacterial-type flagellum-dependent cell motility
TP37_11470	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TP37_11475	COG1749	Flagellar hook protein flgE
TP37_11480	COG4787	bacterial-type flagellum-dependent cell motility
TP37_11485	COG4786	Flagellar basal body rod
TP37_11490	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TP37_11495	COG1706	bacterial-type flagellum-dependent cell motility
TP37_11500	COG3951	Flagellar rod assembly protein muramidase FlgJ
TP37_11500	COG1705	Flagellar rod assembly protein muramidase FlgJ
TP37_11510	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TP37_11520	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TP37_11550	COG2201	protein-glutamate methylesterase activity
TP37_11555	COG2204	response regulator
TP37_11570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TP37_11575	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_11580	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_11590	COG4638	Rieske (2fe-2S)
TP37_11615	COG2963	transposase activity
TP37_11620	COG2801	Transposase and inactivated derivatives
TP37_11625	COG1677	Flagellar hook-basal body complex protein FliE
TP37_11675	COG3190	flagellar
TP37_11695	COG1987	bacterial-type flagellum assembly
TP37_11700	COG1684	flagellar biosynthetic protein fliR
TP37_11715	COG3300	MHYT domain
TP37_11715	COG5001	Diguanylate cyclase
TP37_11725	COG5001	Diguanylate cyclase
TP37_11725	COG3300	MHYT domain
TP37_11750	COG0455	bacterial-type flagellum organization
TP37_11770	COG2198	Histidine kinase
TP37_11770	COG0643	Histidine kinase
TP37_11795	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TP37_11800	COG1360	Flagellar Motor Protein
TP37_11805	COG1192	Involved in chromosome partitioning
TP37_11810	COG0835	chemotaxis
TP37_11820	COG0745	RESPONSE REGULATOR receiver
TP37_11830	COG0840	transmembrane signaling receptor activity
TP37_11845	COG0840	transmembrane signaling receptor activity
TP37_11850	COG0840	transmembrane signaling receptor activity
TP37_11860	COG0840	transmembrane signaling receptor activity
TP37_11880	COG0840	transmembrane signaling receptor activity
TP37_11885	COG3039	Transposase
TP37_11890	COG0840	transmembrane signaling receptor activity
TP37_11895	COG2963	transposase activity
TP37_11900	COG2801	Transposase and inactivated derivatives
TP37_11910	COG0840	transmembrane signaling receptor activity
TP37_11920	COG0840	transmembrane signaling receptor activity
TP37_11925	COG0840	transmembrane signaling receptor activity
TP37_11930	COG0840	transmembrane signaling receptor activity
TP37_11935	COG0840	transmembrane signaling receptor activity
TP37_11940	COG0840	transmembrane signaling receptor activity
TP37_11950	COG0835	chemotaxis
TP37_11960	COG0840	transmembrane signaling receptor activity
TP37_11970	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TP37_11975	COG2201	protein-glutamate methylesterase activity
TP37_11990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TP37_12020	COG0318	PFAM AMP-dependent synthetase and ligase
TP37_12025	COG1024	Enoyl-CoA hydratase
TP37_12030	COG0784	Response regulator, receiver
TP37_12030	COG2205	protein histidine kinase activity
TP37_12030	COG2198	Histidine kinase
TP37_12045	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TP37_12050	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TP37_12065	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TP37_12075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TP37_12080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TP37_12090	COG0505	Belongs to the CarA family
TP37_12095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TP37_12100	COG2258	MOSC domain
TP37_12105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TP37_12150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TP37_12170	COG0277	FAD linked oxidase domain protein
TP37_12175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TP37_12185	COG0531	amino acid
TP37_12190	COG0531	amino acid
TP37_12195	COG0235	Class ii aldolase
TP37_12200	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TP37_12205	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
TP37_12225	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TP37_12225	COG0140	phosphoribosyl-ATP diphosphatase activity
TP37_12230	COG0107	imidazoleglycerol-phosphate synthase activity
TP37_12235	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TP37_12240	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TP37_12245	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TP37_12245	COG0131	Imidazoleglycerol-phosphate dehydratase
TP37_12250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TP37_12255	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TP37_12260	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TP37_12270	COG0124	histidyl-tRNA synthetase
TP37_12275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TP37_12285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TP37_12315	COG3039	Transposase
TP37_12360	COG2205	protein histidine kinase activity
TP37_12360	COG0784	Response regulator, receiver
TP37_12370	COG3039	Transposase
TP37_12395	COG0436	Aminotransferase
TP37_12400	COG4133	protoheme IX ABC transporter activity
TP37_12420	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TP37_12425	COG1138	Cytochrome C-type biogenesis protein
TP37_12445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TP37_12450	COG1278	Cold shock
TP37_12455	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TP37_12460	COG4988	ABC transporter
TP37_12470	COG1294	oxidase, subunit
TP37_12505	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TP37_12510	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TP37_12520	COG0165	Argininosuccinate lyase
TP37_12525	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TP37_12535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TP37_12550	COG0137	argininosuccinate synthase activity
TP37_12555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TP37_12565	COG0215	cysteine-tRNA ligase activity
TP37_12570	COG2166	iron-sulfur cluster assembly
TP37_12580	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TP37_12590	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TP37_12595	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TP37_12615	COG4302	ethanolamine ammonia-lyase activity
TP37_12635	COG2801	Transposase and inactivated derivatives
TP37_12640	COG2963	transposase activity
TP37_12685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TP37_12690	COG0402	S-adenosylhomocysteine deaminase activity
TP37_12700	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TP37_12705	COG1509	lysine 2,3-aminomutase activity
TP37_12710	COG5001	Diguanylate cyclase
TP37_12710	COG3300	MHYT domain
TP37_12725	COG0483	inositol monophosphate 1-phosphatase activity
TP37_12750	COG0513	Belongs to the DEAD box helicase family
TP37_12755	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TP37_12760	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TP37_12770	COG0625	glutathione transferase activity
TP37_12780	COG4681	YaeQ
TP37_12785	COG2081	HI0933 family
TP37_12795	COG0501	Belongs to the peptidase M48B family
TP37_12800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TP37_12805	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_12825	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TP37_12830	COG0860	N-Acetylmuramoyl-L-alanine amidase
TP37_12835	COG0802	atpase or kinase
TP37_12840	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TP37_12840	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TP37_12845	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TP37_12850	COG1570	exodeoxyribonuclease VII activity
TP37_12860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TP37_12900	COG0835	chemotaxis
TP37_12905	COG0840	transmembrane signaling receptor activity
TP37_12910	COG2094	Belongs to the DNA glycosylase MPG family
TP37_12915	COG1201	RNA secondary structure unwinding
TP37_12930	COG2969	positive regulation of protein catabolic process
TP37_12935	COG0625	glutathione transferase activity
TP37_12945	COG2857	Cytochrome c1
TP37_12950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TP37_12955	COG0723	plastoquinol--plastocyanin reductase activity
TP37_12960	COG0741	lytic transglycosylase activity
TP37_12975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TP37_12980	COG1702	phosphate starvation-inducible protein PhoH
TP37_12990	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TP37_13000	COG4535	Mg2 and Co2 transporter CorC
TP37_13015	COG1012	belongs to the aldehyde dehydrogenase family
TP37_13025	COG1177	transmembrane transport
TP37_13030	COG1176	ABC-type spermidine putrescine transport system, permease component I
TP37_13035	COG3842	ATPase activity
TP37_13055	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TP37_13070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TP37_13075	COG0174	glutamine synthetase
TP37_13080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP37_13085	COG0745	RESPONSE REGULATOR receiver
TP37_13085	COG3706	GGDEF domain
TP37_13090	COG2703	oxygen carrier activity
TP37_13095	COG0477	Major facilitator Superfamily
TP37_13105	COG0243	molybdopterin cofactor binding
TP37_13110	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TP37_13130	COG2733	membrane
TP37_13135	COG2205	protein histidine kinase activity
TP37_13135	COG5002	protein histidine kinase activity
TP37_13135	COG0784	Response regulator, receiver
TP37_13150	COG0477	Major facilitator Superfamily
TP37_13205	COG2902	Dehydrogenase
TP37_13215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP37_13220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP37_13225	COG1609	Transcriptional regulator
TP37_13230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TP37_13230	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TP37_13235	COG1105	Belongs to the carbohydrate kinase PfkB family
TP37_13240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TP37_13240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TP37_13255	COG2963	transposase activity
TP37_13260	COG2801	Transposase and inactivated derivatives
TP37_13265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TP37_13275	COG1862	Preprotein translocase
TP37_13280	COG0343	queuine tRNA-ribosyltransferase activity
TP37_13285	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TP37_13325	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TP37_13330	COG3291	Pkd domain containing protein
TP37_13340	COG0405	Gamma-glutamyltransferase
TP37_13345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TP37_13360	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TP37_13365	COG0742	ribosomal rna small subunit methyltransferase
TP37_13370	COG0326	Molecular chaperone. Has ATPase activity
TP37_13475	COG0531	amino acid
TP37_13490	COG0006	proline dipeptidase activity
TP37_13500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TP37_13515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP37_13520	COG3938	Belongs to the proline racemase family
TP37_13530	COG0552	protein localization to endoplasmic reticulum
TP37_13535	COG1194	a g-specific adenine glycosylase
TP37_13540	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TP37_13545	COG0784	Response regulator, receiver
TP37_13545	COG4191	Histidine kinase
TP37_13560	COG0322	excinuclease ABC activity
TP37_13575	COG3040	lipid binding
TP37_13585	COG1960	acyl-CoA dehydrogenase activity
TP37_13595	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TP37_13615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TP37_13620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TP37_13625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TP37_13660	COG0438	transferase activity, transferring glycosyl groups
TP37_13665	COG0438	transferase activity, transferring glycosyl groups
TP37_13710	COG0776	regulation of translation
TP37_13715	COG0072	phenylalanine-tRNA ligase activity
TP37_13715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TP37_13720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TP37_13725	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TP37_13730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TP37_13735	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TP37_13740	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TP37_13755	COG3039	Transposase
TP37_13760	COG1874	Beta-galactosidase
TP37_13760	COG0366	Alpha amylase catalytic
TP37_13765	COG2211	Major facilitator Superfamily
TP37_13765	COG2190	(PTS) system
TP37_13775	COG1082	Xylose isomerase domain protein TIM barrel
TP37_13820	COG0556	nucleotide-excision repair
TP37_13875	COG1611	Belongs to the LOG family
TP37_13885	COG2095	MarC family integral membrane protein
TP37_13895	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TP37_13900	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TP37_13930	COG1185	polyribonucleotide nucleotidyltransferase activity
TP37_13935	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TP37_13940	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TP37_13945	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TP37_13950	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TP37_13955	COG0195	Participates in both transcription termination and antitermination
TP37_13960	COG0779	Required for maturation of 30S ribosomal subunits
TP37_13970	COG1007	ATP synthesis coupled electron transport
TP37_13985	COG0713	ATP synthesis coupled electron transport
TP37_13995	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TP37_14000	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TP37_14010	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TP37_14015	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TP37_14020	COG0649	NAD binding
TP37_14025	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TP37_14030	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TP37_14035	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TP37_14050	COG0149	triose-phosphate isomerase activity
TP37_14090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TP37_14095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TP37_14100	COG0159	tryptophan synthase activity
TP37_14110	COG0133	tryptophan synthase activity
TP37_14120	COG0135	phosphoribosylanthranilate isomerase activity
TP37_14125	COG0101	tRNA pseudouridine synthase activity
TP37_14145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TP37_14150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TP37_14155	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TP37_14160	COG2890	protein-(glutamine-N5) methyltransferase activity
TP37_14170	COG0688	phosphatidylethanolamine metabolic process
TP37_14180	COG0433	COG0433 Predicted ATPase
TP37_14185	COG0494	nUDIX hydrolase
TP37_14210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TP37_14240	COG0717	Belongs to the dCTP deaminase family
TP37_14245	COG0489	protein tyrosine kinase activity
TP37_14250	COG4206	TonB-dependent receptor
TP37_14260	COG3039	Transposase
TP37_14270	COG3590	peptidase
TP37_14275	COG3590	peptidase
TP37_14300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TP37_14305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP37_14310	COG2311	Membrane
TP37_14315	COG1047	Peptidyl-prolyl cis-trans
TP37_14320	COG0791	NLP P60 protein
TP37_14325	COG0791	NLP P60 protein
TP37_14335	COG4106	trans-aconitate 2-methyltransferase activity
TP37_14340	COG1301	dicarboxylic acid transport
TP37_14345	COG1785	Belongs to the alkaline phosphatase family
TP37_14350	COG0037	tRNA processing
TP37_14355	COG1722	exodeoxyribonuclease VII activity
TP37_14360	COG0142	geranyltranstransferase activity
TP37_14385	COG0312	modulator of DNA gyrase
TP37_14390	COG3028	Belongs to the UPF0307 family
TP37_14395	COG0312	modulator of DNA gyrase
TP37_14405	COG3164	Protein of unknown function
TP37_14410	COG1530	ribonuclease E activity
TP37_14415	COG0424	maF-like protein
TP37_14420	COG2968	Membrane
TP37_14435	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TP37_14450	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TP37_14465	COG0495	leucyl-tRNA aminoacylation
TP37_14475	COG3118	belongs to the thioredoxin family
TP37_14505	COG3039	Transposase
TP37_14535	COG2198	Histidine kinase
TP37_14535	COG0643	Histidine kinase
TP37_14540	COG0840	transmembrane signaling receptor activity
TP37_14545	COG0835	chemotaxis
TP37_14550	COG2200	EAL domain
TP37_14550	COG2199	diguanylate cyclase activity
TP37_14550	COG2202	Pas domain
TP37_14555	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TP37_14560	COG2201	protein-glutamate methylesterase activity
TP37_14570	COG3590	peptidase
TP37_14580	COG0588	phosphoglycerate mutase activity
TP37_14585	COG1515	deoxyribonuclease V activity
TP37_14595	COG1741	Belongs to the pirin family
TP37_14610	COG1741	Belongs to the pirin family
TP37_14620	COG2879	small protein
TP37_14625	COG3039	Transposase
TP37_14670	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TP37_14675	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TP37_14680	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TP37_14685	COG2080	2 iron, 2 sulfur cluster binding
TP37_14690	COG3321	synthase
TP37_14690	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_14690	COG0604	alcohol dehydrogenase
TP37_14695	COG2203	Gaf domain
TP37_14695	COG3706	GGDEF domain
TP37_14695	COG4251	negative regulation of phosphorylation
TP37_14695	COG5001	Diguanylate cyclase
TP37_14700	COG0629	single-stranded DNA binding
TP37_14705	COG0142	geranyltranstransferase activity
TP37_14715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TP37_14730	COG0527	aspartate kinase activity
TP37_14735	COG0384	phenazine biosynthesis protein PhzF
TP37_14740	COG0384	phenazine biosynthesis protein PhzF
TP37_14750	COG1764	response to oxidative stress
TP37_14755	COG0540	Belongs to the ATCase OTCase family
TP37_14760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TP37_14765	COG1678	Uncharacterized ACR, COG1678
TP37_14775	COG0519	Catalyzes the synthesis of GMP from XMP
TP37_14800	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TP37_14815	COG0739	heme binding
TP37_14840	COG3039	Transposase
TP37_14855	COG1959	2 iron, 2 sulfur cluster binding
TP37_14860	COG0719	Fe-S assembly protein
TP37_14865	COG0396	ATPase activity
TP37_14870	COG0719	Fe-S assembly protein
TP37_14875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TP37_14890	COG4774	siderophore transport
TP37_14895	COG3128	pkhd-type hydroxylase
TP37_14920	COG1477	protein flavinylation
TP37_14930	COG3039	Transposase
TP37_14960	COG1024	Enoyl-CoA hydratase
TP37_14965	COG1960	acyl-CoA dehydrogenase activity
TP37_14985	COG3867	Arabinogalactan endo-beta-1,4-galactanase
TP37_14990	COG3250	beta-galactosidase activity
TP37_15010	COG2801	Transposase and inactivated derivatives
TP37_15015	COG2963	transposase activity
TP37_15025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TP37_15035	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TP37_15040	COG3039	Transposase
TP37_15065	COG0534	Mate efflux family protein
TP37_15070	COG0335	large ribosomal subunit rRNA binding
TP37_15075	COG0336	Belongs to the RNA methyltransferase TrmD family
TP37_15080	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TP37_15085	COG0228	four-way junction DNA binding
TP37_15100	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TP37_15105	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TP37_15140	COG0784	Response regulator, receiver
TP37_15140	COG4191	Histidine kinase
TP37_15145	COG3850	Histidine kinase
TP37_15145	COG3437	response regulator, receiver
TP37_15145	COG2205	protein histidine kinase activity
TP37_15145	COG4999	Histidine kinase
TP37_15150	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TP37_15160	COG2205	protein histidine kinase activity
TP37_15165	COG5507	3-demethylubiquinone-9 3-methyltransferase
TP37_15175	COG4771	TonB-dependent receptor
TP37_15200	COG2172	sigma factor antagonist activity
TP37_15205	COG1366	Belongs to the anti-sigma-factor antagonist family
TP37_15210	COG1366	Belongs to the anti-sigma-factor antagonist family
TP37_15225	COG2207	Transcriptional regulator
TP37_15230	COG3039	Transposase
TP37_15240	COG3152	Membrane
TP37_15255	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
TP37_15260	COG1845	cytochrome c oxidase, subunit III
TP37_15265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TP37_15315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TP37_15320	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TP37_15325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TP37_15330	COG0196	riboflavin kinase activity
TP37_15340	COG0268	Binds directly to 16S ribosomal RNA
TP37_15345	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TP37_15350	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TP37_15355	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TP37_15360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TP37_15365	COG0824	Thioesterase
TP37_15380	COG1946	Acyl-CoA thioesterase
TP37_15400	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TP37_15410	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TP37_15435	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TP37_15450	COG2197	response regulator
TP37_15455	COG4585	Histidine kinase
TP37_15465	COG0850	regulation of cytokinetic process
TP37_15470	COG2894	cell division
TP37_15475	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TP37_15485	COG0642	Histidine kinase
TP37_15490	COG0745	RESPONSE REGULATOR receiver
TP37_15505	COG2194	sulfuric ester hydrolase activity
TP37_15520	COG2814	Major facilitator Superfamily
TP37_15525	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TP37_15525	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TP37_15535	COG0656	L-ascorbic acid biosynthetic process
TP37_15540	COG0753	catalase activity
TP37_15560	COG1506	peptidase
TP37_15560	COG0823	Involved in the tonB-independent uptake of proteins
TP37_15575	COG1297	OPT oligopeptide transporter protein
TP37_15590	COG0587	DNA-directed DNA polymerase activity
TP37_15610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TP37_15645	COG2080	2 iron, 2 sulfur cluster binding
TP37_15650	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TP37_15655	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TP37_15690	COG0492	ferredoxin-NADP+ reductase activity
TP37_15705	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_15710	COG3537	Alpha-1,2-mannosidase
TP37_15720	COG3387	PFAM Glycoside hydrolase 15-related
TP37_15725	COG3039	Transposase
TP37_15735	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TP37_15740	COG0406	alpha-ribazole phosphatase activity
TP37_15740	COG0328	RNA-DNA hybrid ribonuclease activity
TP37_15810	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TP37_15835	COG1309	transcriptional regulator
TP37_15840	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_15850	COG0308	aminopeptidase N
TP37_15855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TP37_15860	COG0330	HflC and HflK could
TP37_15865	COG0330	HflC and HflK could
TP37_15885	COG0678	peroxiredoxin activity
TP37_15895	COG4953	penicillin-binding protein 1C
TP37_15910	COG2373	Large extracellular alpha-helical protein
TP37_15925	COG2828	Protein conserved in bacteria
TP37_15955	COG3829	transcription factor binding
TP37_15965	COG4974	Belongs to the 'phage' integrase family
TP37_16000	COG0740	serine-type endopeptidase activity
TP37_16045	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TP37_16050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TP37_16060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TP37_16065	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_16070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TP37_16080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TP37_16090	COG1399	metal-binding, possibly nucleic acid-binding protein
TP37_16095	COG0424	maF-like protein
TP37_16120	COG0714	Associated with various cellular activities
TP37_16140	COG0537	adenosine 5'-monophosphoramidase activity
TP37_16145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TP37_16150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TP37_16165	COG0314	molybdopterin synthase activity
TP37_16170	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TP37_16175	COG0315	cyclic pyranopterin monophosphate synthase activity
TP37_16185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TP37_16190	COG1234	tRNA 3'-trailer cleavage
TP37_16195	COG3642	lipopolysaccharide core region biosynthetic process
TP37_16200	COG0859	PFAM glycosyl transferase family 9
TP37_16215	COG0631	protein serine/threonine phosphatase activity
TP37_16220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TP37_16225	COG0328	RNA-DNA hybrid ribonuclease activity
TP37_16235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TP37_16245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TP37_16275	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TP37_16280	COG0740	serine-type endopeptidase activity
TP37_16285	COG0544	peptidyl-prolyl cis-trans isomerase activity
TP37_16395	COG0473	3-isopropylmalate dehydrogenase activity
TP37_16410	COG4783	chaperone-mediated protein folding
TP37_16425	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TP37_16435	COG0438	transferase activity, transferring glycosyl groups
TP37_16440	COG0671	phosphoesterase, PA-phosphatase related
TP37_16445	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TP37_16460	COG2833	Protein of unknown function (DUF455)
TP37_16480	COG0285	dihydrofolate synthase activity
TP37_16485	COG0406	alpha-ribazole phosphatase activity
TP37_16505	COG1063	alcohol dehydrogenase
TP37_16515	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TP37_16520	COG4208	sulfate ABC transporter
TP37_16525	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
TP37_16530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
TP37_16535	COG0156	8-amino-7-oxononanoate synthase activity
TP37_16560	COG0604	alcohol dehydrogenase
TP37_16565	COG1902	pentaerythritol trinitrate reductase activity
TP37_16565	COG0446	pyridine nucleotide-disulphide oxidoreductase
TP37_16590	COG0625	glutathione transferase activity
TP37_16595	COG0039	L-malate dehydrogenase activity
TP37_16600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TP37_16615	COG0154	amidase activity
TP37_16625	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TP37_16640	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TP37_16655	COG0203	ribosomal protein L17
TP37_16660	COG0202	RNA polymerase activity
TP37_16665	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TP37_16670	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TP37_16675	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TP37_16680	COG0201	protein transport
TP37_16685	COG0200	Binds to the 23S rRNA
TP37_16690	COG1841	ribosomal large subunit assembly
TP37_16695	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TP37_16700	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TP37_16705	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TP37_16710	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TP37_16715	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TP37_16720	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TP37_16725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TP37_16730	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TP37_16735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TP37_16740	COG0255	Belongs to the universal ribosomal protein uL29 family
TP37_16745	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TP37_16750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TP37_16755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TP37_16760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TP37_16765	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TP37_16770	COG0089	rRNA binding
TP37_16775	COG0088	Forms part of the polypeptide exit tunnel
TP37_16780	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TP37_16785	COG0051	transcription antitermination factor activity, RNA binding
TP37_16790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TP37_16795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TP37_16800	COG0049	tRNA binding
TP37_16805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TP37_16810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TP37_16815	COG0085	RNA polymerase activity
TP37_16820	COG0222	ribosome binding
TP37_16825	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TP37_16830	COG0081	regulation of translation
TP37_16835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TP37_16840	COG0250	Participates in transcription elongation, termination and antitermination
TP37_16845	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TP37_16855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TP37_16875	COG0012	GTP binding
TP37_16880	COG0193	aminoacyl-tRNA hydrolase activity
TP37_16885	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TP37_16890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TP37_16900	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TP37_16905	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
TP37_16915	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TP37_16920	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TP37_16930	COG0521	Mo-molybdopterin cofactor biosynthetic process
TP37_16945	COG1254	Belongs to the acylphosphatase family
TP37_16950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TP37_16955	COG1295	ribonuclease BN
TP37_16985	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TP37_16990	COG1404	Belongs to the peptidase S8 family
TP37_17000	COG1404	Belongs to the peptidase S8 family
TP37_17005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TP37_17020	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TP37_17025	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TP37_17045	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TP37_17050	COG3039	Transposase
TP37_17085	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TP37_17085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TP37_17105	COG2890	protein-(glutamine-N5) methyltransferase activity
TP37_17115	COG3634	alkyl hydroperoxide reductase activity
TP37_17120	COG0583	DNA-binding transcription factor activity
TP37_17125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TP37_17130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TP37_17140	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TP37_17150	COG2197	response regulator
TP37_17160	COG0745	RESPONSE REGULATOR receiver
TP37_17160	COG3706	GGDEF domain
TP37_17175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TP37_17185	COG0697	spore germination
TP37_17210	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
TP37_17240	COG1024	Enoyl-CoA hydratase
TP37_17250	COG3039	Transposase
TP37_17260	COG2951	lytic endotransglycosylase activity
TP37_17265	COG4644	lycopene metabolic process
TP37_17285	COG2963	transposase activity
TP37_17290	COG2801	Transposase and inactivated derivatives
TP37_17300	COG3039	Transposase
TP37_17325	COG0583	DNA-binding transcription factor activity
TP37_17330	COG3384	dioxygenase
TP37_17360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TP37_17365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TP37_17395	COG1196	nuclear chromosome segregation
TP37_17425	COG0123	including yeast histone deacetylase and acetoin utilization protein
TP37_17430	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TP37_17435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TP37_17440	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TP37_17445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TP37_17450	COG2967	ApaG domain
TP37_17455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TP37_17505	COG0431	NADPH-dependent FMN reductase
TP37_17510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TP37_17520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TP37_17525	COG1116	anion transmembrane transporter activity
TP37_17535	COG3829	transcription factor binding
TP37_17550	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TP37_17555	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TP37_17575	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TP37_17585	COG0642	Histidine kinase
TP37_17600	COG4181	ATPase activity
TP37_17610	COG2175	clavaminate synthase activity
TP37_17620	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TP37_17625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TP37_17645	COG4771	TonB-dependent receptor
TP37_17650	COG3039	Transposase
TP37_17660	COG0667	Aldo Keto reductase
TP37_17670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TP37_17675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TP37_17685	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TP37_17690	COG4106	trans-aconitate 2-methyltransferase activity
TP37_17700	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TP37_17755	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TP37_17770	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TP37_17775	COG2226	methyltransferase
TP37_17810	COG0366	Alpha amylase catalytic
TP37_17830	COG3321	synthase
TP37_17830	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_17830	COG0604	alcohol dehydrogenase
TP37_17840	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TP37_17850	COG0494	nUDIX hydrolase
TP37_17855	COG0653	protein targeting
TP37_17860	COG0739	heme binding
TP37_17870	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TP37_17885	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TP37_17890	COG1181	Belongs to the D-alanine--D-alanine ligase family
TP37_17895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TP37_17900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TP37_17910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TP37_17915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TP37_17920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TP37_17930	COG3116	cell division
TP37_17935	COG0275	rRNA processing
TP37_17940	COG2001	Belongs to the MraZ family
TP37_17960	COG0792	nuclease activity
TP37_17965	COG1988	membrane-bound metal-dependent
TP37_17970	COG0277	FAD linked oxidase domain protein
TP37_17975	COG0745	RESPONSE REGULATOR receiver
TP37_17980	COG2205	protein histidine kinase activity
TP37_17985	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TP37_17990	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TP37_17995	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TP37_18030	COG2963	transposase activity
TP37_18035	COG2801	Transposase and inactivated derivatives
TP37_18040	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TP37_18045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TP37_18050	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TP37_18070	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TP37_18070	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TP37_18080	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TP37_18085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TP37_18095	COG0488	(ABC) transporter
TP37_18105	COG0697	spore germination
TP37_18115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TP37_18125	COG3791	Glutathione-dependent formaldehyde-activating
TP37_18150	COG0745	RESPONSE REGULATOR receiver
TP37_18155	COG2205	protein histidine kinase activity
TP37_18175	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TP37_18180	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TP37_18195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TP37_18205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TP37_18210	COG1012	belongs to the aldehyde dehydrogenase family
TP37_18215	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
TP37_18220	COG0617	tRNA 3'-terminal CCA addition
TP37_18235	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TP37_18240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TP37_18245	COG1609	Transcriptional regulator
TP37_18315	COG4795	General secretion pathway protein
TP37_18335	COG1459	type II secretion system
TP37_18390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TP37_18395	COG4191	Histidine kinase
TP37_18400	COG0784	Response regulator, receiver
TP37_18405	COG4251	negative regulation of phosphorylation
TP37_18410	COG2823	Periplasmic or secreted lipoprotein
TP37_18415	COG0673	inositol 2-dehydrogenase activity
TP37_18420	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TP37_18455	COG1056	cytidyltransferase-related domain
TP37_18455	COG1051	belongs to the nudix hydrolase family
TP37_18465	COG0583	DNA-binding transcription factor activity
TP37_18480	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TP37_18485	COG0321	lipoyl(octanoyl) transferase activity
TP37_18490	COG2921	Belongs to the UPF0250 family
TP37_18500	COG1686	Belongs to the peptidase S11 family
TP37_18505	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TP37_18510	COG2951	lytic endotransglycosylase activity
TP37_18520	COG0772	Belongs to the SEDS family
TP37_18535	COG1792	Involved in formation and maintenance of cell shape
TP37_18540	COG1077	Cell shape determining protein MreB Mrl
TP37_18550	COG3284	Transcriptional regulator
TP37_18570	COG2010	Cytochrome c
TP37_18600	COG0308	aminopeptidase N
TP37_18610	COG2226	methyltransferase
TP37_18635	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TP37_18640	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TP37_18645	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TP37_18655	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TP37_18665	COG2832	Protein of unknown function (DUF454)
TP37_18680	COG1505	serine-type exopeptidase activity
TP37_18705	COG0181	hydroxymethylbilane synthase activity
TP37_18715	COG3275	phosphorelay sensor kinase activity
TP37_18725	COG2943	transferase activity, transferring hexosyl groups
TP37_18735	COG3706	GGDEF domain
TP37_18740	COG0659	secondary active sulfate transmembrane transporter activity
TP37_18750	COG0840	transmembrane signaling receptor activity
TP37_18755	COG3039	Transposase
TP37_18815	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
TP37_18825	COG0598	Magnesium transport protein CorA
TP37_18835	COG1113	amino acid transport
TP37_18855	COG0697	spore germination
TP37_18875	COG3706	GGDEF domain
TP37_18885	COG0823	Involved in the tonB-independent uptake of proteins
TP37_18885	COG1506	peptidase
TP37_18920	COG0435	Glutathione S-transferase
TP37_18930	COG4221	oxidoreductase activity
TP37_18945	COG4221	oxidoreductase activity
TP37_18955	COG1573	uracil-dna glycosylase
TP37_18965	COG3384	dioxygenase
TP37_18975	COG0583	DNA-binding transcription factor activity
TP37_18985	COG0667	Aldo Keto reductase
TP37_18995	COG3590	peptidase
TP37_19010	COG0531	amino acid
TP37_19025	COG2972	Histidine kinase
TP37_19040	COG3685	Protein conserved in bacteria
TP37_19045	COG3546	catalase activity
TP37_19080	COG2204	response regulator
TP37_19090	COG3039	Transposase
TP37_19095	COG1271	oxidase subunit
TP37_19100	COG1294	oxidase, subunit
TP37_19115	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_19120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TP37_19155	COG1132	(ABC) transporter
TP37_19170	COG1063	alcohol dehydrogenase
TP37_19250	COG2963	transposase activity
TP37_19255	COG2801	Transposase and inactivated derivatives
TP37_19340	COG0047	phosphoribosylformylglycinamidine synthase activity
TP37_19340	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TP37_19345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TP37_19355	COG4974	Belongs to the 'phage' integrase family
TP37_19370	COG0795	lipopolysaccharide-transporting ATPase activity
TP37_19380	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TP37_19395	COG0525	valine-tRNA ligase activity
TP37_19405	COG3039	Transposase
TP37_19440	COG1183	phosphatidylcholine synthase activity
TP37_19450	COG0442	prolyl-tRNA aminoacylation
TP37_19470	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TP37_19475	COG1127	ABC transporter
TP37_19480	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TP37_19480	COG3218	ABC-type transport auxiliary lipoprotein component
TP37_19510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TP37_19515	COG0662	Cupin 2, conserved barrel domain protein
TP37_19515	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TP37_19545	COG2086	electron transfer activity
TP37_19560	COG0546	phosphoglycolate phosphatase activity
TP37_19560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TP37_19565	COG0277	FAD linked oxidase domain protein
TP37_19575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TP37_19720	COG1802	Transcriptional regulator
TP37_19720	COG4626	Terminase
TP37_19765	COG3179	chitinase
TP37_19785	COG3657	addiction module killer protein
TP37_19805	COG0305	Participates in initiation and elongation during chromosome replication
TP37_19925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TP37_19930	COG1490	D-aminoacyl-tRNA deacylase activity
TP37_19935	COG1560	Kdo2-lipid A biosynthetic process
TP37_19985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TP37_19985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TP37_19990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TP37_19995	COG0242	peptide deformylase activity
TP37_20000	COG1652	LysM domain
TP37_20035	COG1196	nuclear chromosome segregation
TP37_20080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TP37_20080	COG1754	DNA topoisomerase type I activity
TP37_20085	COG0009	L-threonylcarbamoyladenylate synthase
TP37_20100	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_20110	COG0616	signal peptide processing
TP37_20115	COG0534	Mate efflux family protein
TP37_20135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TP37_20140	COG0625	glutathione transferase activity
TP37_20155	COG1252	NADH dehydrogenase
TP37_20160	COG2860	membrane
TP37_20165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TP37_20170	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TP37_20175	COG2201	protein-glutamate methylesterase activity
TP37_20180	COG2177	Part of the ABC transporter FtsEX involved in
TP37_20185	COG2884	Cell division ATP-binding protein ftsE
TP37_20190	COG0513	Belongs to the DEAD box helicase family
TP37_20195	COG3118	belongs to the thioredoxin family
TP37_20200	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TP37_20205	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
TP37_20210	COG0583	DNA-binding transcription factor activity
TP37_20230	COG1652	LysM domain
TP37_20235	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TP37_20235	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TP37_20240	COG1473	amidohydrolase
TP37_20245	COG3039	Transposase
TP37_20250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP37_20255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP37_20285	COG5383	Protein conserved in bacteria
TP37_20330	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
TP37_20335	COG3023	N-Acetylmuramoyl-L-alanine amidase
TP37_20345	COG4948	Mandelate Racemase Muconate Lactonizing
TP37_20355	COG0531	amino acid
TP37_20370	COG4682	membrane
TP37_20375	COG2133	pyrroloquinoline quinone binding
TP37_20385	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TP37_20390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TP37_20395	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TP37_20400	COG1610	YqeY-like protein
TP37_20405	COG1295	ribonuclease BN
TP37_20410	COG0358	DNA primase activity
TP37_20425	COG0109	protoheme IX farnesyltransferase activity
TP37_20455	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
TP37_20470	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TP37_20485	COG2963	transposase activity
TP37_20490	COG2801	Transposase and inactivated derivatives
TP37_20530	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TP37_20535	COG0739	heme binding
TP37_20540	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TP37_20550	COG2223	nitrite transmembrane transporter activity
TP37_20555	COG0708	Exodeoxyribonuclease III
TP37_20560	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TP37_20570	COG1192	Involved in chromosome partitioning
TP37_20575	COG1475	DNA binding
TP37_20590	COG0463	Glycosyl transferase, family 2
TP37_20610	COG0756	dUTP diphosphatase activity
TP37_20615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TP37_20620	COG2003	Belongs to the UPF0758 family
TP37_20625	COG0018	arginyl-trna synthetase
TP37_20640	COG4221	oxidoreductase activity
TP37_20645	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TP37_20645	COG2755	lipolytic protein G-D-S-L family
TP37_20655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TP37_20660	COG1166	arginine decarboxylase activity
TP37_20665	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TP37_20690	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TP37_20690	COG3291	Pkd domain containing protein
TP37_20705	COG0606	chelatase, subunit chli
TP37_20720	COG4943	cyclic-guanylate-specific phosphodiesterase activity
TP37_20760	COG1690	Belongs to the RtcB family
TP37_20800	COG1090	epimerase
TP37_20805	COG0745	RESPONSE REGULATOR receiver
TP37_20810	COG0642	Histidine kinase
TP37_20845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TP37_20870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TP37_20875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TP37_20895	COG0753	catalase activity
TP37_20910	COG2197	response regulator
TP37_20915	COG4585	Histidine kinase
TP37_20920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP37_20925	COG1136	(ABC) transporter
TP37_20950	COG0697	spore germination
TP37_20965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TP37_20970	COG0180	Tryptophanyl-tRNA synthetase
TP37_20975	COG3237	CsbD-like
TP37_21015	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TP37_21095	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TP37_21185	COG4373	Mu-like prophage FluMu protein gp28
TP37_21280	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TP37_21285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TP37_21285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TP37_21310	COG2205	protein histidine kinase activity
TP37_21315	COG0745	RESPONSE REGULATOR receiver
TP37_21325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TP37_21350	COG1199	ATP-dependent helicase activity
TP37_21365	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TP37_21420	COG3039	Transposase
TP37_21425	COG0625	glutathione transferase activity
TP37_21470	COG1476	TRANSCRIPTIONal
TP37_21490	COG1230	cation diffusion facilitator family transporter
TP37_21495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TP37_21500	COG1131	(ABC) transporter
TP37_21505	COG0842	Transport permease protein
TP37_21510	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TP37_21555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TP37_21560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TP37_21570	COG0045	succinate-CoA ligase (ADP-forming) activity
TP37_21570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TP37_21570	COG1042	CoA-binding domain protein
TP37_21575	COG2239	Acts as a magnesium transporter
TP37_21590	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TP37_21595	COG3387	PFAM Glycoside hydrolase 15-related
TP37_21610	COG3100	YcgL domain-containing protein
TP37_21615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TP37_21625	COG0463	Glycosyl transferase, family 2
TP37_21635	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_21670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TP37_21685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TP37_21710	COG4946	Tricorn protease homolog
TP37_21710	COG1506	peptidase
TP37_21710	COG0823	Involved in the tonB-independent uptake of proteins
TP37_21725	COG0408	coproporphyrinogen oxidase activity
TP37_21770	COG0515	serine threonine protein kinase
TP37_21775	COG0631	protein serine/threonine phosphatase activity
TP37_21800	COG0667	Aldo Keto reductase
TP37_21805	COG0583	DNA-binding transcription factor activity
TP37_21820	COG3501	Rhs element vgr protein
TP37_21845	COG1595	DNA-templated transcription, initiation
TP37_21970	COG0210	DNA helicase
TP37_21980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP37_21985	COG0583	DNA-binding transcription factor activity
TP37_21990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TP37_22000	COG2159	amidohydrolase
TP37_22005	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TP37_22010	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TP37_22025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP37_22045	COG0357	Ribosomal RNA small subunit methyltransferase G
TP37_22050	COG3540	Alkaline phosphatase
TP37_22060	COG2091	lysine biosynthetic process via aminoadipic acid
TP37_22080	COG0708	Exodeoxyribonuclease III
TP37_22105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TP37_22115	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TP37_22120	COG3162	membrane
TP37_22130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TP37_22160	COG3507	Belongs to the glycosyl hydrolase 43 family
TP37_22180	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_22185	COG0179	Fumarylacetoacetate (FAA) hydrolase
TP37_22190	COG4948	Mandelate Racemase Muconate Lactonizing
TP37_22195	COG3254	rhamnose metabolic process
TP37_22200	COG0738	Major facilitator superfamily
TP37_22205	COG1414	Transcriptional regulator
TP37_22210	COG1971	Probably functions as a manganese efflux pump
TP37_22215	COG2205	protein histidine kinase activity
TP37_22225	COG3459	Glycosyltransferase 36 associated
TP37_22230	COG2211	Major facilitator Superfamily
TP37_22235	COG3265	gluconokinase activity
TP37_22240	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TP37_22260	COG2911	Protein conserved in bacteria
TP37_22265	COG0729	surface antigen
TP37_22280	COG3039	Transposase
TP37_22285	COG3039	Transposase
TP37_22310	COG0752	glycyl-tRNA synthetase alpha subunit
TP37_22315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TP37_22325	COG0519	Catalyzes the synthesis of GMP from XMP
TP37_22325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TP37_22335	COG0805	protein transport
TP37_22340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TP37_22345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TP37_22355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TP37_22375	COG2974	May be involved in recombination
TP37_22380	COG0037	tRNA processing
TP37_22385	COG2115	Belongs to the xylose isomerase family
TP37_22395	COG3661	Belongs to the glycosyl hydrolase 67 family
TP37_22405	COG4948	Mandelate Racemase Muconate Lactonizing
TP37_22415	COG1472	Belongs to the glycosyl hydrolase 3 family
TP37_22420	COG0246	Mannitol dehydrogenase
TP37_22460	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TP37_22485	COG3386	PFAM SMP-30 Gluconolaconase
TP37_22495	COG3250	beta-galactosidase activity
TP37_22500	COG1904	glucuronate isomerase
TP37_22505	COG3693	PFAM glycoside hydrolase, family 10
TP37_22520	COG3693	PFAM glycoside hydrolase, family 10
TP37_22535	COG2211	Major facilitator Superfamily
TP37_22570	COG0604	alcohol dehydrogenase
TP37_22570	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_22570	COG3321	synthase
TP37_22575	COG2937	Belongs to the GPAT DAPAT family
TP37_22610	COG0284	orotidine-5'-phosphate decarboxylase activity
TP37_22615	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
TP37_22620	COG3132	Protein of unknown function, DUF480
TP37_22635	COG0210	DNA helicase
TP37_22640	COG3039	Transposase
TP37_22645	COG1435	thymidine kinase activity
TP37_22655	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
TP37_22675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TP37_22705	COG3135	benzoate transporter
TP37_22725	COG0676	glucose-6-phosphate 1-epimerase activity
TP37_22735	COG3012	SEC-C Motif Domain Protein
TP37_22740	COG0730	response to heat
TP37_22760	COG0302	gtp cyclohydrolase
TP37_22775	COG1566	PFAM secretion protein HlyD family protein
TP37_22785	COG1289	transmembrane transporter activity
TP37_22790	COG0477	Major facilitator Superfamily
TP37_22800	COG0583	DNA-binding transcription factor activity
TP37_22805	COG4221	oxidoreductase activity
TP37_22815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP37_22870	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TP37_22880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TP37_22910	COG1028	Short-chain dehydrogenase reductase Sdr
TP37_22935	COG0439	Biotin carboxylase
TP37_22975	COG1127	ABC transporter
TP37_22980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TP37_22985	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TP37_23000	COG2853	Lipoprotein
TP37_23010	COG0386	Belongs to the glutathione peroxidase family
TP37_23030	COG0625	glutathione transferase activity
TP37_23040	COG0531	amino acid
TP37_23045	COG3537	Alpha-1,2-mannosidase
TP37_23070	COG3706	GGDEF domain
TP37_23075	COG3835	regulator
TP37_23080	COG1929	Belongs to the glycerate kinase type-1 family
TP37_23085	COG2271	Major facilitator Superfamily
TP37_23100	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TP37_23105	COG0861	Integral membrane protein TerC family
TP37_23115	COG0584	glycerophosphoryl diester phosphodiesterase
TP37_23130	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TP37_23145	COG0706	membrane insertase activity
TP37_23150	COG0594	ribonuclease P activity
TP37_23155	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TP37_23175	COG2801	Transposase and inactivated derivatives
TP37_23190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP37_23285	COG3012	SEC-C Motif Domain Protein
TP37_23285	COG3318	Belongs to the UPF0149 family
TP37_23400	COG1192	Involved in chromosome partitioning
TP37_23405	COG2963	transposase activity
TP37_23410	COG2801	Transposase and inactivated derivatives
TP37_23460	COG3039	Transposase
TP37_23475	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TP37_23520	COG3077	Addiction module antitoxin, RelB DinJ family
TP37_23525	COG3041	Addiction module toxin RelE StbE family
TP37_23595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP37_23615	COG2948	multi-organism process
TP37_23620	COG3504	Conjugal transfer protein