locus-tag	class	description
TP45_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TP45_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TP45_00020	COG0187	DNA topoisomerase II activity
TP45_00030	COG0501	Belongs to the peptidase M48B family
TP45_00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TP45_00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP45_00115	COG0793	Belongs to the peptidase S41A family
TP45_00120	COG4942	peptidase
TP45_00130	COG2234	aminopeptidase activity
TP45_00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TP45_00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TP45_00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TP45_00160	COG1064	alcohol dehydrogenase
TP45_00195	COG0778	Nitroreductase
TP45_00200	COG2353	YceI-like domain
TP45_00230	COG3052	prosthetic group binding
TP45_00250	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
TP45_00255	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TP45_00265	COG1802	Transcriptional regulator
TP45_00325	COG2963	transposase activity
TP45_00330	COG2801	Transposase and inactivated derivatives
TP45_00345	COG3039	Transposase
TP45_00355	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TP45_00385	COG4772	TonB-dependent receptor
TP45_00400	COG1012	belongs to the aldehyde dehydrogenase family
TP45_00425	COG1304	FMN binding
TP45_00435	COG4585	Histidine kinase
TP45_00440	COG2197	response regulator
TP45_00460	COG3710	Transcriptional regulator
TP45_00465	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TP45_00485	COG3039	Transposase
TP45_00510	COG0714	Associated with various cellular activities
TP45_00560	COG0477	Major facilitator Superfamily
TP45_00565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TP45_00620	COG3237	CsbD-like
TP45_00660	COG2963	transposase activity
TP45_00665	COG2801	Transposase and inactivated derivatives
TP45_00675	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TP45_00725	COG3039	Transposase
TP45_00730	COG2249	NAD(P)H dehydrogenase (quinone) activity
TP45_00755	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_00760	COG0300	oxidoreductase activity
TP45_00775	COG1272	protein, Hemolysin III
TP45_00780	COG1111	helicase
TP45_00780	COG1205	dead DEAH box helicase
TP45_00860	COG0069	glutamate synthase activity
TP45_00860	COG0070	glutamate synthase
TP45_00860	COG0067	glutamate synthase
TP45_00865	COG0493	'glutamate synthase
TP45_00900	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TP45_00930	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TP45_00945	COG0459	protein refolding
TP45_00950	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TP45_00955	COG2356	endonuclease I
TP45_00960	COG1324	tolerance protein
TP45_00970	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TP45_00975	COG0511	ligase activity, forming carbon-carbon bonds
TP45_00985	COG0439	Biotin carboxylase
TP45_01000	COG2264	protein methyltransferase activity
TP45_01025	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
TP45_01030	COG4589	Belongs to the CDS family
TP45_01055	COG0671	phosphoesterase, PA-phosphatase related
TP45_01055	COG2453	phosphatase
TP45_01060	COG2267	carboxylic ester hydrolase activity
TP45_01065	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TP45_01070	COG0138	bifunctional purine biosynthesis protein purh
TP45_01080	COG0151	Belongs to the GarS family
TP45_01090	COG1289	transmembrane transporter activity
TP45_01095	COG2814	Major facilitator Superfamily
TP45_01105	COG2814	Major facilitator Superfamily
TP45_01120	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TP45_01135	COG0316	Belongs to the HesB IscA family
TP45_01175	COG1051	belongs to the nudix hydrolase family
TP45_01190	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TP45_01195	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TP45_01200	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TP45_01210	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TP45_01215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TP45_01225	COG0134	indole-3-glycerol-phosphate synthase activity
TP45_01230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TP45_01255	COG1597	lipid kinase activity
TP45_01260	COG0456	acetyltransferase
TP45_01275	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TP45_01280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TP45_01305	COG2111	Na H antiporter
TP45_01305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TP45_01310	COG1006	Multisubunit Na H antiporter MnhC subunit
TP45_01315	COG0651	ATP synthesis coupled electron transport
TP45_01325	COG2212	antiporter activity
TP45_01330	COG1320	monovalent cation:proton antiporter activity
TP45_01345	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
TP45_01365	COG3104	oligopeptide transport
TP45_01370	COG3483	tryptophan 2,3-dioxygenase activity
TP45_01380	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TP45_01395	COG0508	dehydrogenase complex catalyzes the overall conversion of
TP45_01400	COG0513	Belongs to the DEAD box helicase family
TP45_01410	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_01415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP45_01455	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_01460	COG0702	epimerase
TP45_01485	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TP45_01490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TP45_01495	COG0297	glycogen (starch) synthase activity
TP45_01500	COG0745	RESPONSE REGULATOR receiver
TP45_01500	COG3706	GGDEF domain
TP45_01505	COG2354	Protein conserved in bacteria
TP45_01510	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TP45_01515	COG1368	sulfuric ester hydrolase activity
TP45_01520	COG1511	domain protein
TP45_01520	COG3264	Mechanosensitive ion channel
TP45_01595	COG0210	DNA helicase
TP45_01605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP45_01610	COG0583	DNA-binding transcription factor activity
TP45_01615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TP45_01625	COG2159	amidohydrolase
TP45_01630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TP45_01635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TP45_01645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP45_01665	COG0357	Ribosomal RNA small subunit methyltransferase G
TP45_01670	COG3540	Alkaline phosphatase
TP45_01680	COG2091	lysine biosynthetic process via aminoadipic acid
TP45_01700	COG0708	Exodeoxyribonuclease III
TP45_01705	COG1846	Transcriptional regulator
TP45_01705	COG1940	carbohydrate kinase activity
TP45_01715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TP45_01725	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TP45_01730	COG3162	membrane
TP45_01740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TP45_01770	COG3507	Belongs to the glycosyl hydrolase 43 family
TP45_01790	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_01795	COG0179	Fumarylacetoacetate (FAA) hydrolase
TP45_01800	COG4948	Mandelate Racemase Muconate Lactonizing
TP45_01805	COG3254	rhamnose metabolic process
TP45_01810	COG0738	Major facilitator superfamily
TP45_01815	COG1414	Transcriptional regulator
TP45_01820	COG1971	Probably functions as a manganese efflux pump
TP45_01825	COG2205	protein histidine kinase activity
TP45_01835	COG3459	Glycosyltransferase 36 associated
TP45_01840	COG2211	Major facilitator Superfamily
TP45_01845	COG3265	gluconokinase activity
TP45_01850	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TP45_01870	COG2911	Protein conserved in bacteria
TP45_01875	COG0729	surface antigen
TP45_01890	COG3039	Transposase
TP45_01930	COG3039	Transposase
TP45_01945	COG0752	glycyl-tRNA synthetase alpha subunit
TP45_01950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TP45_01975	COG0519	Catalyzes the synthesis of GMP from XMP
TP45_01975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TP45_01985	COG0805	protein transport
TP45_01990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TP45_01995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TP45_02005	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TP45_02025	COG2974	May be involved in recombination
TP45_02030	COG0037	tRNA processing
TP45_02035	COG2115	Belongs to the xylose isomerase family
TP45_02045	COG3661	Belongs to the glycosyl hydrolase 67 family
TP45_02055	COG4948	Mandelate Racemase Muconate Lactonizing
TP45_02070	COG3039	Transposase
TP45_02075	COG0246	Mannitol dehydrogenase
TP45_02120	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TP45_02145	COG3386	PFAM SMP-30 Gluconolaconase
TP45_02155	COG3250	beta-galactosidase activity
TP45_02160	COG1904	glucuronate isomerase
TP45_02180	COG3693	PFAM glycoside hydrolase, family 10
TP45_02195	COG2211	Major facilitator Superfamily
TP45_02245	COG2963	transposase activity
TP45_02250	COG2801	Transposase and inactivated derivatives
TP45_02280	COG5297	Belongs to the glycosyl hydrolase family 6
TP45_02335	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TP45_02425	COG4221	oxidoreductase activity
TP45_02440	COG4221	oxidoreductase activity
TP45_02450	COG0435	Glutathione S-transferase
TP45_02485	COG0823	Involved in the tonB-independent uptake of proteins
TP45_02485	COG1506	peptidase
TP45_02500	COG3706	GGDEF domain
TP45_02520	COG0697	spore germination
TP45_02540	COG1113	amino acid transport
TP45_02550	COG0598	Magnesium transport protein CorA
TP45_02560	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
TP45_02595	COG0840	transmembrane signaling receptor activity
TP45_02600	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TP45_02600	COG5297	Belongs to the glycosyl hydrolase family 6
TP45_02605	COG0659	secondary active sulfate transmembrane transporter activity
TP45_02610	COG3706	GGDEF domain
TP45_02620	COG2943	transferase activity, transferring hexosyl groups
TP45_02630	COG3275	phosphorelay sensor kinase activity
TP45_02640	COG0181	hydroxymethylbilane synthase activity
TP45_02665	COG1505	serine-type exopeptidase activity
TP45_02680	COG2832	Protein of unknown function (DUF454)
TP45_02690	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TP45_02700	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TP45_02705	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TP45_02710	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TP45_02735	COG2226	methyltransferase
TP45_02740	COG3300	MHYT domain
TP45_02740	COG5001	Diguanylate cyclase
TP45_02745	COG0308	aminopeptidase N
TP45_02790	COG3284	Transcriptional regulator
TP45_02800	COG1077	Cell shape determining protein MreB Mrl
TP45_02805	COG1792	Involved in formation and maintenance of cell shape
TP45_02820	COG0772	Belongs to the SEDS family
TP45_02830	COG2951	lytic endotransglycosylase activity
TP45_02835	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TP45_02840	COG1686	Belongs to the peptidase S11 family
TP45_02850	COG2921	Belongs to the UPF0250 family
TP45_02855	COG0321	lipoyl(octanoyl) transferase activity
TP45_02860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TP45_02875	COG0583	DNA-binding transcription factor activity
TP45_02885	COG1056	cytidyltransferase-related domain
TP45_02885	COG1051	belongs to the nudix hydrolase family
TP45_02920	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TP45_02930	COG2823	Periplasmic or secreted lipoprotein
TP45_02935	COG4251	negative regulation of phosphorylation
TP45_02940	COG0784	Response regulator, receiver
TP45_02945	COG4191	Histidine kinase
TP45_02950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TP45_03005	COG1459	type II secretion system
TP45_03025	COG4795	General secretion pathway protein
TP45_03055	COG3250	beta-galactosidase activity
TP45_03080	COG1609	Transcriptional regulator
TP45_03085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TP45_03090	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TP45_03105	COG0617	tRNA 3'-terminal CCA addition
TP45_03110	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
TP45_03115	COG1012	belongs to the aldehyde dehydrogenase family
TP45_03120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TP45_03130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TP45_03145	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TP45_03150	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TP45_03170	COG2205	protein histidine kinase activity
TP45_03175	COG0745	RESPONSE REGULATOR receiver
TP45_03200	COG3791	Glutathione-dependent formaldehyde-activating
TP45_03210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TP45_03220	COG0697	spore germination
TP45_03230	COG0488	(ABC) transporter
TP45_03240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TP45_03245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TP45_03255	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TP45_03255	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TP45_03275	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TP45_03280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TP45_03285	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TP45_03305	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TP45_03310	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TP45_03315	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TP45_03320	COG2205	protein histidine kinase activity
TP45_03325	COG0745	RESPONSE REGULATOR receiver
TP45_03330	COG0277	FAD linked oxidase domain protein
TP45_03335	COG1988	membrane-bound metal-dependent
TP45_03340	COG0792	nuclease activity
TP45_03360	COG2001	Belongs to the MraZ family
TP45_03365	COG0275	rRNA processing
TP45_03370	COG3116	cell division
TP45_03385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TP45_03390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TP45_03395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TP45_03405	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TP45_03410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TP45_03415	COG1181	Belongs to the D-alanine--D-alanine ligase family
TP45_03420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TP45_03435	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TP45_03445	COG0739	heme binding
TP45_03450	COG0653	protein targeting
TP45_03455	COG0494	nUDIX hydrolase
TP45_03465	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TP45_03475	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_03475	COG3321	synthase
TP45_03475	COG0604	alcohol dehydrogenase
TP45_03495	COG0366	Alpha amylase catalytic
TP45_03530	COG2226	methyltransferase
TP45_03535	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TP45_03550	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TP45_03590	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TP45_03600	COG4106	trans-aconitate 2-methyltransferase activity
TP45_03605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TP45_03615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TP45_03620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TP45_03625	COG0667	Aldo Keto reductase
TP45_03635	COG4771	TonB-dependent receptor
TP45_03655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TP45_03660	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TP45_03670	COG2175	clavaminate synthase activity
TP45_03680	COG4181	ATPase activity
TP45_03695	COG0642	Histidine kinase
TP45_03705	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TP45_03725	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TP45_03730	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TP45_03745	COG3829	transcription factor binding
TP45_03755	COG1116	anion transmembrane transporter activity
TP45_03760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TP45_03770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TP45_03775	COG0431	NADPH-dependent FMN reductase
TP45_03785	COG3039	Transposase
TP45_03800	COG0747	negative chemotaxis
TP45_03820	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TP45_03825	COG2967	ApaG domain
TP45_03830	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TP45_03835	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TP45_03840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TP45_03845	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TP45_03850	COG0123	including yeast histone deacetylase and acetoin utilization protein
TP45_03855	COG2096	Adenosyltransferase
TP45_03865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TP45_03870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TP45_03900	COG3384	dioxygenase
TP45_03905	COG0583	DNA-binding transcription factor activity
TP45_03920	COG1024	Enoyl-CoA hydratase
TP45_03950	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
TP45_03975	COG0697	spore germination
TP45_03985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TP45_04000	COG3706	GGDEF domain
TP45_04000	COG0745	RESPONSE REGULATOR receiver
TP45_04010	COG2197	response regulator
TP45_04020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TP45_04030	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TP45_04035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TP45_04040	COG0583	DNA-binding transcription factor activity
TP45_04045	COG3634	alkyl hydroperoxide reductase activity
TP45_04055	COG2890	protein-(glutamine-N5) methyltransferase activity
TP45_04075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TP45_04075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TP45_04105	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TP45_04125	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TP45_04130	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TP45_04145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TP45_04150	COG1404	Belongs to the peptidase S8 family
TP45_04155	COG1404	Belongs to the peptidase S8 family
TP45_04160	COG1404	Belongs to the peptidase S8 family
TP45_04165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TP45_04195	COG1295	ribonuclease BN
TP45_04200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TP45_04205	COG1254	Belongs to the acylphosphatase family
TP45_04220	COG0521	Mo-molybdopterin cofactor biosynthetic process
TP45_04230	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TP45_04235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TP45_04245	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
TP45_04250	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TP45_04260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TP45_04265	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TP45_04270	COG0193	aminoacyl-tRNA hydrolase activity
TP45_04275	COG0012	GTP binding
TP45_04295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TP45_04305	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TP45_04310	COG0250	Participates in transcription elongation, termination and antitermination
TP45_04315	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TP45_04320	COG0081	regulation of translation
TP45_04325	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TP45_04330	COG0222	ribosome binding
TP45_04335	COG0085	RNA polymerase activity
TP45_04340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TP45_04345	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TP45_04350	COG0049	tRNA binding
TP45_04355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TP45_04360	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TP45_04365	COG0051	transcription antitermination factor activity, RNA binding
TP45_04370	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TP45_04375	COG0088	Forms part of the polypeptide exit tunnel
TP45_04380	COG0089	rRNA binding
TP45_04385	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TP45_04390	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TP45_04395	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TP45_04400	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TP45_04405	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TP45_04410	COG0255	Belongs to the universal ribosomal protein uL29 family
TP45_04415	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TP45_04420	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TP45_04425	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TP45_04430	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TP45_04435	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TP45_04440	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TP45_04445	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TP45_04450	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TP45_04455	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TP45_04460	COG1841	ribosomal large subunit assembly
TP45_04465	COG0200	Binds to the 23S rRNA
TP45_04470	COG0201	protein transport
TP45_04475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TP45_04480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TP45_04485	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TP45_04490	COG0202	RNA polymerase activity
TP45_04495	COG0203	ribosomal protein L17
TP45_04500	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TP45_04515	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TP45_04525	COG0154	amidase activity
TP45_04540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TP45_04545	COG0039	L-malate dehydrogenase activity
TP45_04550	COG0625	glutathione transferase activity
TP45_04560	COG1902	pentaerythritol trinitrate reductase activity
TP45_04560	COG0446	pyridine nucleotide-disulphide oxidoreductase
TP45_04565	COG0604	alcohol dehydrogenase
TP45_04590	COG0156	8-amino-7-oxononanoate synthase activity
TP45_04595	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
TP45_04600	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
TP45_04605	COG4208	sulfate ABC transporter
TP45_04610	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TP45_04620	COG1063	alcohol dehydrogenase
TP45_04640	COG0406	alpha-ribazole phosphatase activity
TP45_04645	COG0285	dihydrofolate synthase activity
TP45_04665	COG2833	Protein of unknown function (DUF455)
TP45_04680	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TP45_04685	COG0671	phosphoesterase, PA-phosphatase related
TP45_04690	COG0438	transferase activity, transferring glycosyl groups
TP45_04700	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TP45_04715	COG4783	chaperone-mediated protein folding
TP45_04730	COG0473	3-isopropylmalate dehydrogenase activity
TP45_04770	COG0544	peptidyl-prolyl cis-trans isomerase activity
TP45_04775	COG0740	serine-type endopeptidase activity
TP45_04780	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TP45_04810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TP45_04820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TP45_04830	COG0328	RNA-DNA hybrid ribonuclease activity
TP45_04835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TP45_04840	COG0631	protein serine/threonine phosphatase activity
TP45_04855	COG0859	PFAM glycosyl transferase family 9
TP45_04860	COG3642	lipopolysaccharide core region biosynthetic process
TP45_04865	COG1234	tRNA 3'-trailer cleavage
TP45_04870	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TP45_04880	COG0315	cyclic pyranopterin monophosphate synthase activity
TP45_04885	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TP45_04890	COG0314	molybdopterin synthase activity
TP45_04905	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TP45_04910	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TP45_04915	COG0537	adenosine 5'-monophosphoramidase activity
TP45_04935	COG0714	Associated with various cellular activities
TP45_04955	COG0424	maF-like protein
TP45_04960	COG1399	metal-binding, possibly nucleic acid-binding protein
TP45_04970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TP45_04980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TP45_04985	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_04990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TP45_05000	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TP45_05005	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TP45_05030	COG3829	transcription factor binding
TP45_05070	COG2373	Large extracellular alpha-helical protein
TP45_05085	COG4953	penicillin-binding protein 1C
TP45_05095	COG0678	peroxiredoxin activity
TP45_05115	COG0330	HflC and HflK could
TP45_05120	COG0330	HflC and HflK could
TP45_05130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TP45_05135	COG0308	aminopeptidase N
TP45_05145	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_05150	COG1309	transcriptional regulator
TP45_05205	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TP45_05210	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
TP45_05215	COG0732	type I restriction modification DNA specificity domain
TP45_05220	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TP45_05245	COG0328	RNA-DNA hybrid ribonuclease activity
TP45_05245	COG0406	alpha-ribazole phosphatase activity
TP45_05250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TP45_05265	COG3387	PFAM Glycoside hydrolase 15-related
TP45_05270	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_05275	COG3537	Alpha-1,2-mannosidase
TP45_05280	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_05295	COG0492	ferredoxin-NADP+ reductase activity
TP45_05320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TP45_05325	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TP45_05330	COG2080	2 iron, 2 sulfur cluster binding
TP45_05365	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TP45_05385	COG0587	DNA-directed DNA polymerase activity
TP45_05400	COG1297	OPT oligopeptide transporter protein
TP45_05415	COG0823	Involved in the tonB-independent uptake of proteins
TP45_05415	COG1506	peptidase
TP45_05435	COG2207	Transcriptional regulator
TP45_05435	COG1917	Cupin 2, conserved barrel domain protein
TP45_05450	COG0753	catalase activity
TP45_05455	COG0656	L-ascorbic acid biosynthetic process
TP45_05465	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TP45_05465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TP45_05470	COG2814	Major facilitator Superfamily
TP45_05485	COG2194	sulfuric ester hydrolase activity
TP45_05500	COG0745	RESPONSE REGULATOR receiver
TP45_05505	COG0642	Histidine kinase
TP45_05515	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TP45_05520	COG2894	cell division
TP45_05525	COG0850	regulation of cytokinetic process
TP45_05535	COG4585	Histidine kinase
TP45_05540	COG2197	response regulator
TP45_05555	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TP45_05580	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TP45_05590	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TP45_05610	COG1946	Acyl-CoA thioesterase
TP45_05625	COG0824	Thioesterase
TP45_05630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TP45_05635	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TP45_05640	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TP45_05645	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TP45_05650	COG0268	Binds directly to 16S ribosomal RNA
TP45_05660	COG0196	riboflavin kinase activity
TP45_05665	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TP45_05670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TP45_05675	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TP45_05710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TP45_05715	COG1845	cytochrome c oxidase, subunit III
TP45_05720	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
TP45_05735	COG3152	Membrane
TP45_05745	COG2207	Transcriptional regulator
TP45_05750	COG0326	Molecular chaperone. Has ATPase activity
TP45_05760	COG1366	Belongs to the anti-sigma-factor antagonist family
TP45_05765	COG1366	Belongs to the anti-sigma-factor antagonist family
TP45_05770	COG2172	sigma factor antagonist activity
TP45_05795	COG4771	TonB-dependent receptor
TP45_05805	COG5507	3-demethylubiquinone-9 3-methyltransferase
TP45_05815	COG2205	protein histidine kinase activity
TP45_05825	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TP45_05830	COG4999	Histidine kinase
TP45_05830	COG3850	Histidine kinase
TP45_05830	COG3437	response regulator, receiver
TP45_05830	COG2205	protein histidine kinase activity
TP45_05835	COG4191	Histidine kinase
TP45_05835	COG0784	Response regulator, receiver
TP45_05865	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TP45_05870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TP45_05885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TP45_05890	COG0228	four-way junction DNA binding
TP45_05895	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TP45_05900	COG0336	Belongs to the RNA methyltransferase TrmD family
TP45_05905	COG0335	large ribosomal subunit rRNA binding
TP45_05910	COG0534	Mate efflux family protein
TP45_05935	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TP45_05945	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TP45_05955	COG3483	tryptophan 2,3-dioxygenase activity
TP45_05995	COG3250	beta-galactosidase activity
TP45_06000	COG3867	Arabinogalactan endo-beta-1,4-galactanase
TP45_06020	COG1960	acyl-CoA dehydrogenase activity
TP45_06025	COG1024	Enoyl-CoA hydratase
TP45_06045	COG2801	Transposase and inactivated derivatives
TP45_06050	COG2963	transposase activity
TP45_06055	COG3039	Transposase
TP45_06060	COG3039	Transposase
TP45_06070	COG2963	transposase activity
TP45_06100	COG2755	lipolytic protein G-D-S-L family
TP45_06100	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TP45_06105	COG4221	oxidoreductase activity
TP45_06120	COG0018	arginyl-trna synthetase
TP45_06125	COG2003	Belongs to the UPF0758 family
TP45_06130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TP45_06135	COG0756	dUTP diphosphatase activity
TP45_06155	COG0463	Glycosyl transferase, family 2
TP45_06175	COG1475	DNA binding
TP45_06180	COG1192	Involved in chromosome partitioning
TP45_06190	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TP45_06195	COG0708	Exodeoxyribonuclease III
TP45_06200	COG2223	nitrite transmembrane transporter activity
TP45_06210	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TP45_06215	COG0739	heme binding
TP45_06220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TP45_06260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TP45_06275	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
TP45_06305	COG0109	protoheme IX farnesyltransferase activity
TP45_06320	COG0358	DNA primase activity
TP45_06325	COG1295	ribonuclease BN
TP45_06330	COG1610	YqeY-like protein
TP45_06335	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TP45_06340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TP45_06345	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TP45_06355	COG2133	pyrroloquinoline quinone binding
TP45_06360	COG4682	membrane
TP45_06375	COG0531	amino acid
TP45_06385	COG4948	Mandelate Racemase Muconate Lactonizing
TP45_06395	COG3023	N-Acetylmuramoyl-L-alanine amidase
TP45_06400	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
TP45_06450	COG5383	Protein conserved in bacteria
TP45_06470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP45_06475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP45_06480	COG1473	amidohydrolase
TP45_06485	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TP45_06485	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TP45_06510	COG0583	DNA-binding transcription factor activity
TP45_06515	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
TP45_06520	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TP45_06525	COG3118	belongs to the thioredoxin family
TP45_06530	COG0513	Belongs to the DEAD box helicase family
TP45_06535	COG2884	Cell division ATP-binding protein ftsE
TP45_06540	COG2177	Part of the ABC transporter FtsEX involved in
TP45_06545	COG2201	protein-glutamate methylesterase activity
TP45_06550	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TP45_06555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TP45_06560	COG2860	membrane
TP45_06565	COG1252	NADH dehydrogenase
TP45_06580	COG0625	glutathione transferase activity
TP45_06585	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TP45_06605	COG0534	Mate efflux family protein
TP45_06610	COG0616	signal peptide processing
TP45_06625	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_06640	COG0009	L-threonylcarbamoyladenylate synthase
TP45_06645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TP45_06645	COG1754	DNA topoisomerase type I activity
TP45_06665	COG0758	DNA mediated transformation
TP45_06670	COG1652	LysM domain
TP45_06675	COG0242	peptide deformylase activity
TP45_06680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TP45_06685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TP45_06685	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TP45_06735	COG1560	Kdo2-lipid A biosynthetic process
TP45_06740	COG1490	D-aminoacyl-tRNA deacylase activity
TP45_06745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TP45_06810	COG2963	transposase activity
TP45_06965	COG4695	Portal protein
TP45_06980	COG3039	Transposase
TP45_06995	COG0840	transmembrane signaling receptor activity
TP45_07010	COG0251	oxidation-reduction process
TP45_07085	COG1063	alcohol dehydrogenase
TP45_07100	COG1132	(ABC) transporter
TP45_07120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TP45_07125	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_07140	COG1294	oxidase, subunit
TP45_07145	COG1271	oxidase subunit
TP45_07155	COG2204	response regulator
TP45_07190	COG3546	catalase activity
TP45_07195	COG3685	Protein conserved in bacteria
TP45_07210	COG2972	Histidine kinase
TP45_07225	COG0531	amino acid
TP45_07240	COG3590	peptidase
TP45_07250	COG0667	Aldo Keto reductase
TP45_07260	COG0583	DNA-binding transcription factor activity
TP45_07270	COG3384	dioxygenase
TP45_07280	COG1573	uracil-dna glycosylase
TP45_07285	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
TP45_07290	COG0025	NhaP-type Na H and K H
TP45_07295	COG1131	(ABC) transporter
TP45_07300	COG0842	Transport permease protein
TP45_07350	COG1522	sequence-specific DNA binding
TP45_07355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP45_07360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TP45_07380	COG2205	protein histidine kinase activity
TP45_07380	COG2202	Pas domain
TP45_07400	COG2813	Specifically methylates the guanine in position
TP45_07405	COG1187	pseudouridine synthase activity
TP45_07410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TP45_07435	COG2198	Histidine kinase
TP45_07435	COG5002	protein histidine kinase activity
TP45_07435	COG0784	Response regulator, receiver
TP45_07445	COG1666	GTP binding
TP45_07450	COG0697	spore germination
TP45_07455	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TP45_07460	COG2011	ABC-type metal ion transport system permease component
TP45_07485	COG3039	Transposase
TP45_07505	COG0508	dehydrogenase complex catalyzes the overall conversion of
TP45_07515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TP45_07535	COG0356	it plays a direct role in the translocation of protons across the membrane
TP45_07545	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TP45_07550	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TP45_07555	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TP45_07560	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TP45_07565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TP45_07570	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TP45_07590	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TP45_07595	COG4191	Histidine kinase
TP45_07600	COG2204	response regulator
TP45_07610	COG0577	efflux transmembrane transporter activity
TP45_07610	COG1136	(ABC) transporter
TP45_07615	COG0577	efflux transmembrane transporter activity
TP45_07620	COG3039	Transposase
TP45_07625	COG1136	(ABC) transporter
TP45_07630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP45_07635	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TP45_07670	COG2132	Multicopper oxidase
TP45_07685	COG0339	signal peptide processing
TP45_07700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TP45_07705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TP45_07710	COG0546	phosphoglycolate phosphatase activity
TP45_07720	COG2819	hydrolase of the alpha beta superfamily
TP45_07730	COG1956	GAF domain-containing protein
TP45_07735	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TP45_07765	COG0720	synthase
TP45_07770	COG4771	TonB-dependent receptor
TP45_07780	COG0513	Belongs to the DEAD box helicase family
TP45_07790	COG0625	glutathione transferase activity
TP45_07820	COG0626	cystathionine gamma-synthase activity
TP45_07830	COG0438	transferase activity, transferring glycosyl groups
TP45_07850	COG0438	transferase activity, transferring glycosyl groups
TP45_07855	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TP45_07870	COG2963	transposase activity
TP45_07880	COG2801	Transposase and inactivated derivatives
TP45_07885	COG2963	transposase activity
TP45_07910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TP45_07920	COG0277	FAD linked oxidase domain protein
TP45_07925	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TP45_07925	COG0546	phosphoglycolate phosphatase activity
TP45_07940	COG2086	electron transfer activity
TP45_07970	COG0662	Cupin 2, conserved barrel domain protein
TP45_07970	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TP45_07975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TP45_08005	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TP45_08005	COG3218	ABC-type transport auxiliary lipoprotein component
TP45_08010	COG1127	ABC transporter
TP45_08015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TP45_08050	COG1131	(ABC) transporter
TP45_08055	COG0346	lactoylglutathione lyase activity
TP45_08060	COG0833	amino acid
TP45_08065	COG2040	homocysteine
TP45_08075	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
TP45_08095	COG1695	Transcriptional regulator
TP45_08130	COG0825	malonyl-CoA metabolic process
TP45_08145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TP45_08150	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TP45_08155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TP45_08160	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TP45_08175	COG0750	zinc metalloprotease
TP45_08180	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TP45_08185	COG0575	Belongs to the CDS family
TP45_08190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TP45_08195	COG0233	cytoplasmic translational termination
TP45_08200	COG0528	UMP kinase activity
TP45_08205	COG0745	RESPONSE REGULATOR receiver
TP45_08205	COG3706	GGDEF domain
TP45_08210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TP45_08215	COG0052	Belongs to the universal ribosomal protein uS2 family
TP45_08250	COG0024	Methionine aminopeptidase
TP45_08255	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TP45_08265	COG1393	Belongs to the ArsC family
TP45_08270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TP45_08275	COG0367	asparagine synthase
TP45_08285	COG4774	siderophore transport
TP45_08300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TP45_08325	COG1566	PFAM secretion protein HlyD family protein
TP45_08330	COG2814	Major facilitator Superfamily
TP45_08380	COG0339	signal peptide processing
TP45_08385	COG0386	Belongs to the glutathione peroxidase family
TP45_08440	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TP45_08445	COG0084	hydrolase, TatD family'
TP45_08460	COG1960	acyl-CoA dehydrogenase activity
TP45_08480	COG0367	asparagine synthase
TP45_08490	COG0305	Participates in initiation and elongation during chromosome replication
TP45_08495	COG0415	Belongs to the DNA photolyase family
TP45_08505	COG0583	DNA-binding transcription factor activity
TP45_08540	COG3706	GGDEF domain
TP45_08575	COG0322	excinuclease ABC activity
TP45_08580	COG1484	DNA-dependent DNA replication
TP45_08585	COG4584	PFAM Integrase catalytic
TP45_08615	COG3039	Transposase
TP45_08625	COG1595	DNA-templated transcription, initiation
TP45_08630	COG3712	iron ion homeostasis
TP45_08655	COG4206	TonB-dependent receptor
TP45_08670	COG3039	Transposase
TP45_08685	COG3039	Transposase
TP45_08695	COG1162	GTPase activity
TP45_08720	COG2211	Major facilitator Superfamily
TP45_08725	COG1609	Transcriptional regulator
TP45_08730	COG3039	Transposase
TP45_08735	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_08740	COG2851	Citrate transporter
TP45_08755	COG0642	Histidine kinase
TP45_08760	COG1840	ABC-type Fe3 transport system, periplasmic component
TP45_08765	COG2197	response regulator
TP45_08780	COG0667	Aldo Keto reductase
TP45_08790	COG0583	DNA-binding transcription factor activity
TP45_08820	COG1301	dicarboxylic acid transport
TP45_08825	COG0280	phosphate acetyltransferase
TP45_08825	COG0281	malic enzyme
TP45_08855	COG2801	Transposase and inactivated derivatives
TP45_08860	COG2963	transposase activity
TP45_08880	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TP45_08895	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TP45_08905	COG0497	DNA recombination
TP45_08910	COG1420	regulation of RNA biosynthetic process
TP45_08915	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TP45_08920	COG0443	Heat shock 70 kDa protein
TP45_08925	COG0484	heat shock protein binding
TP45_08930	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
TP45_08960	COG0583	DNA-binding transcription factor activity
TP45_08965	COG1132	(ABC) transporter
TP45_08980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TP45_08990	COG0567	Dehydrogenase, E1 component
TP45_09000	COG2850	peptidyl-arginine hydroxylation
TP45_09025	COG1253	flavin adenine dinucleotide binding
TP45_09030	COG0114	fumarate hydratase activity
TP45_09055	COG1131	(ABC) transporter
TP45_09060	COG1725	Transcriptional regulator
TP45_09065	COG0386	Belongs to the glutathione peroxidase family
TP45_09080	COG2900	Belongs to the SlyX family
TP45_09105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TP45_09115	COG1410	methionine synthase
TP45_09115	COG0646	methionine synthase
TP45_09120	COG1410	methionine synthase
TP45_09120	COG0646	methionine synthase
TP45_09130	COG1960	acyl-CoA dehydrogenase activity
TP45_09135	COG1960	acyl-CoA dehydrogenase activity
TP45_09140	COG1960	acyl-CoA dehydrogenase activity
TP45_09145	COG1960	acyl-CoA dehydrogenase activity
TP45_09150	COG1960	acyl-CoA dehydrogenase activity
TP45_09155	COG1960	acyl-CoA dehydrogenase activity
TP45_09160	COG1960	acyl-CoA dehydrogenase activity
TP45_09165	COG1960	acyl-CoA dehydrogenase activity
TP45_09170	COG1960	acyl-CoA dehydrogenase activity
TP45_09185	COG0557	exoribonuclease II activity
TP45_09205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TP45_09210	COG3706	GGDEF domain
TP45_09215	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TP45_09225	COG0704	Plays a role in the regulation of phosphate uptake
TP45_09230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TP45_09235	COG0581	inorganic phosphate transmembrane transporter activity
TP45_09240	COG0573	inorganic phosphate transmembrane transporter activity
TP45_09245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TP45_09270	COG0659	secondary active sulfate transmembrane transporter activity
TP45_09275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TP45_09285	COG1024	Enoyl-CoA hydratase
TP45_09295	COG0494	nUDIX hydrolase
TP45_09335	COG0116	Belongs to the methyltransferase superfamily
TP45_09335	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TP45_09340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TP45_09360	COG2925	Exonuclease
TP45_09365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TP45_09370	COG3844	kynureninase activity
TP45_09380	COG0662	Cupin 2, conserved barrel domain protein
TP45_09385	COG0288	reversible hydration of carbon dioxide
TP45_09470	COG0017	Asparaginyl-tRNA synthetase
TP45_09475	COG0316	Belongs to the HesB IscA family
TP45_09480	COG0360	Binds together with S18 to 16S ribosomal RNA
TP45_09485	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TP45_09490	COG0359	binds to the 23S rRNA
TP45_09505	COG3115	cell septum assembly
TP45_09520	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TP45_09525	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TP45_09535	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TP45_09545	COG4993	Dehydrogenase
TP45_09555	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TP45_09565	COG2986	histidine ammonia-lyase
TP45_09570	COG1228	amidohydrolase
TP45_09610	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
TP45_09615	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TP45_09620	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TP45_09625	COG1605	Chorismate mutase
TP45_09625	COG0077	Prephenate dehydratase
TP45_09630	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TP45_09645	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TP45_09650	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TP45_09655	COG0583	DNA-binding transcription factor activity
TP45_09670	COG0840	transmembrane signaling receptor activity
TP45_09700	COG0784	Response regulator, receiver
TP45_09700	COG2205	protein histidine kinase activity
TP45_09700	COG5002	protein histidine kinase activity
TP45_09705	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TP45_09710	COG4191	Histidine kinase
TP45_09710	COG0784	Response regulator, receiver
TP45_09725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TP45_09735	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TP45_09745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TP45_09760	COG1595	DNA-templated transcription, initiation
TP45_09810	COG2244	polysaccharide biosynthetic process
TP45_09840	COG2264	protein methyltransferase activity
TP45_09865	COG1136	(ABC) transporter
TP45_09875	COG0477	Major facilitator Superfamily
TP45_09880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TP45_09895	COG1253	flavin adenine dinucleotide binding
TP45_09905	COG0306	phosphate transporter
TP45_09930	COG0504	CTP synthase activity
TP45_09945	COG0148	phosphopyruvate hydratase activity
TP45_09950	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TP45_09955	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TP45_09960	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TP45_09965	COG0585	pseudouridine synthase activity
TP45_09970	COG2840	Smr protein MutS2
TP45_09975	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TP45_09980	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TP45_09985	COG1238	metal cluster binding
TP45_10000	COG1534	Rna-binding protein
TP45_10005	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TP45_10010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TP45_10015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TP45_10020	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TP45_10025	COG1923	regulation of RNA biosynthetic process
TP45_10030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TP45_10035	COG1546	Belongs to the CinA family
TP45_10045	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TP45_10050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TP45_10055	COG2137	regulation of response to DNA damage stimulus
TP45_10060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TP45_10065	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TP45_10080	COG1741	Belongs to the pirin family
TP45_10090	COG0583	DNA-binding transcription factor activity
TP45_10115	COG0351	phosphomethylpyrimidine kinase
TP45_10130	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TP45_10135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TP45_10150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TP45_10160	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TP45_10165	COG3734	2-keto-3-deoxy-galactonokinase
TP45_10175	COG4948	Mandelate Racemase Muconate Lactonizing
TP45_10180	COG0800	Aldolase
TP45_10220	COG1501	Belongs to the glycosyl hydrolase 31 family
TP45_10230	COG1070	Carbohydrate kinase
TP45_10235	COG2115	Belongs to the xylose isomerase family
TP45_10240	COG0477	Major facilitator Superfamily
TP45_10265	COG1469	GTP cyclohydrolase I activity
TP45_10285	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TP45_10290	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TP45_10295	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TP45_10320	COG1472	Belongs to the glycosyl hydrolase 3 family
TP45_10330	COG2203	Gaf domain
TP45_10330	COG4251	negative regulation of phosphorylation
TP45_10330	COG5001	Diguanylate cyclase
TP45_10330	COG3706	GGDEF domain
TP45_10335	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TP45_10340	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TP45_10350	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TP45_10355	COG0671	phosphoesterase, PA-phosphatase related
TP45_10365	COG1794	racemase activity, acting on amino acids and derivatives
TP45_10370	COG0697	spore germination
TP45_10375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TP45_10380	COG0167	dihydroorotate dehydrogenase activity
TP45_10395	COG1012	belongs to the aldehyde dehydrogenase family
TP45_10405	COG3039	Transposase
TP45_10410	COG2963	transposase activity
TP45_10415	COG2801	Transposase and inactivated derivatives
TP45_10440	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TP45_10450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TP45_10455	COG0124	histidyl-tRNA synthetase
TP45_10465	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TP45_10470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TP45_10475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TP45_10480	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TP45_10480	COG0131	Imidazoleglycerol-phosphate dehydratase
TP45_10485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TP45_10490	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TP45_10495	COG0107	imidazoleglycerol-phosphate synthase activity
TP45_10500	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TP45_10500	COG0140	phosphoribosyl-ATP diphosphatase activity
TP45_10520	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
TP45_10525	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TP45_10530	COG0235	Class ii aldolase
TP45_10535	COG0531	amino acid
TP45_10540	COG0531	amino acid
TP45_10550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TP45_10555	COG0277	FAD linked oxidase domain protein
TP45_10575	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TP45_10620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TP45_10625	COG2258	MOSC domain
TP45_10630	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TP45_10635	COG0505	Belongs to the CarA family
TP45_10645	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TP45_10650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TP45_10660	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TP45_10670	COG3279	Response regulator of the LytR AlgR family
TP45_10675	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TP45_10680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TP45_10695	COG2198	Histidine kinase
TP45_10695	COG2205	protein histidine kinase activity
TP45_10695	COG0784	Response regulator, receiver
TP45_10700	COG1024	Enoyl-CoA hydratase
TP45_10705	COG0318	PFAM AMP-dependent synthetase and ligase
TP45_10740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TP45_10750	COG2201	protein-glutamate methylesterase activity
TP45_10755	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TP45_10765	COG0840	transmembrane signaling receptor activity
TP45_10775	COG0835	chemotaxis
TP45_10785	COG0840	transmembrane signaling receptor activity
TP45_10790	COG0840	transmembrane signaling receptor activity
TP45_10795	COG0840	transmembrane signaling receptor activity
TP45_10800	COG0840	transmembrane signaling receptor activity
TP45_10805	COG0840	transmembrane signaling receptor activity
TP45_10815	COG0840	transmembrane signaling receptor activity
TP45_10830	COG0840	transmembrane signaling receptor activity
TP45_10840	COG0840	transmembrane signaling receptor activity
TP45_10845	COG0840	transmembrane signaling receptor activity
TP45_10845	COG0840	transmembrane signaling receptor activity
TP45_10860	COG0840	transmembrane signaling receptor activity
TP45_10870	COG0745	RESPONSE REGULATOR receiver
TP45_10880	COG0835	chemotaxis
TP45_10885	COG1192	Involved in chromosome partitioning
TP45_10890	COG1360	Flagellar Motor Protein
TP45_10895	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TP45_10965	COG0643	Histidine kinase
TP45_10965	COG2198	Histidine kinase
TP45_10985	COG0455	bacterial-type flagellum organization
TP45_11010	COG3300	MHYT domain
TP45_11010	COG5001	Diguanylate cyclase
TP45_11025	COG1684	flagellar biosynthetic protein fliR
TP45_11030	COG1987	bacterial-type flagellum assembly
TP45_11045	COG3190	flagellar
TP45_11095	COG1677	Flagellar hook-basal body complex protein FliE
TP45_11155	COG3039	Transposase
TP45_11165	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_11170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TP45_11185	COG2204	response regulator
TP45_11190	COG2201	protein-glutamate methylesterase activity
TP45_11220	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TP45_11230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TP45_11240	COG3951	Flagellar rod assembly protein muramidase FlgJ
TP45_11240	COG1705	Flagellar rod assembly protein muramidase FlgJ
TP45_11245	COG1706	bacterial-type flagellum-dependent cell motility
TP45_11250	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TP45_11255	COG4786	Flagellar basal body rod
TP45_11260	COG4787	bacterial-type flagellum-dependent cell motility
TP45_11265	COG1749	Flagellar hook protein flgE
TP45_11270	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TP45_11275	COG1558	bacterial-type flagellum-dependent cell motility
TP45_11285	COG0835	chemotaxis
TP45_11285	COG0784	Response regulator, receiver
TP45_11305	COG5002	protein histidine kinase activity
TP45_11335	COG2915	High frequency lysogenization protein hflD homolog
TP45_11340	COG0482	sulfurtransferase activity
TP45_11350	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TP45_11355	COG0542	response to heat
TP45_11360	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TP45_11365	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TP45_11375	COG0492	ferredoxin-NADP+ reductase activity
TP45_11380	COG1674	ftsk spoiiie
TP45_11390	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TP45_11400	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TP45_11405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TP45_11410	COG0183	Belongs to the thiolase family
TP45_11415	COG1024	Enoyl-CoA hydratase
TP45_11415	COG1250	3-hydroxyacyl-CoA dehydrogenase
TP45_11425	COG0105	UTP biosynthetic process
TP45_11430	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TP45_11440	COG1426	Protein conserved in bacteria
TP45_11450	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TP45_11455	COG1160	GTP binding
TP45_11460	COG0303	'Molybdopterin
TP45_11465	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TP45_11500	COG0708	Exodeoxyribonuclease III
TP45_11510	COG0303	'Molybdopterin
TP45_11515	COG0746	molybdenum cofactor guanylyltransferase activity
TP45_11545	COG1914	H( )-stimulated, divalent metal cation uptake system
TP45_11550	COG1321	iron dependent repressor
TP45_11555	COG0590	tRNA wobble adenosine to inosine editing
TP45_11560	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TP45_11565	COG0668	transmembrane transport
TP45_11575	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TP45_11590	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_11595	COG1183	phosphatidylcholine synthase activity
TP45_11605	COG3243	poly(R)-hydroxyalkanoic acid synthase
TP45_11620	COG0723	plastoquinol--plastocyanin reductase activity
TP45_11620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP45_11630	COG2183	response to ionizing radiation
TP45_11705	COG0800	Aldolase
TP45_11710	COG0129	dihydroxy-acid dehydratase activity
TP45_11715	COG0363	glucosamine-6-phosphate deaminase activity
TP45_11720	COG0837	glucose binding
TP45_11725	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TP45_11735	COG0354	folic acid binding
TP45_11745	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TP45_11760	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TP45_11765	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
TP45_11775	COG4591	ABC-type transport system involved in lipoprotein release permease component
TP45_11780	COG1136	(ABC) transporter
TP45_11795	COG0811	peptide transport
TP45_11800	COG0848	biopolymer transport protein
TP45_11805	COG1132	(ABC) transporter
TP45_11810	COG1663	tetraacyldisaccharide 4'-kinase activity
TP45_11815	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TP45_11820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TP45_11845	COG0322	excinuclease ABC activity
TP45_11850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TP45_11875	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TP45_11915	COG3064	Membrane
TP45_11920	COG0428	transporter
TP45_11930	COG2154	pterin-4-alpha-carbinolamine dehydratase
TP45_11935	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TP45_11935	COG0316	Belongs to the HesB IscA family
TP45_11955	COG2951	lytic endotransglycosylase activity
TP45_11960	COG4644	lycopene metabolic process
TP45_11990	COG3920	Histidine kinase
TP45_12005	COG3039	Transposase
TP45_12025	COG0583	DNA-binding transcription factor activity
TP45_12035	COG2963	transposase activity
TP45_12060	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_12065	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
TP45_12070	COG1073	alpha beta
TP45_12070	COG2226	methyltransferase
TP45_12110	COG5001	Diguanylate cyclase
TP45_12130	COG3685	Protein conserved in bacteria
TP45_12145	COG1648	precorrin-2 dehydrogenase activity
TP45_12145	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TP45_12160	COG2814	Major facilitator Superfamily
TP45_12175	COG1335	isochorismatase
TP45_12215	COG0583	DNA-binding transcription factor activity
TP45_12220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TP45_12225	COG3002	Belongs to the UPF0753 family
TP45_12280	COG0582	viral genome integration into host DNA
TP45_12285	COG0519	Catalyzes the synthesis of GMP from XMP
TP45_12285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TP45_12295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TP45_12305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TP45_12305	COG0475	glutathione-regulated potassium exporter activity
TP45_12310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TP45_12320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TP45_12325	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
TP45_12335	COG0776	regulation of translation
TP45_12340	COG0539	negative regulation of cytoplasmic translation
TP45_12350	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TP45_12360	COG2957	Belongs to the agmatine deiminase family
TP45_12365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TP45_12390	COG0395	ABC-type sugar transport system, permease component
TP45_12425	COG2350	Protein conserved in bacteria
TP45_12430	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TP45_12435	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TP45_12440	COG1187	pseudouridine synthase activity
TP45_12455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TP45_12460	COG0436	Aminotransferase
TP45_12465	COG4133	protoheme IX ABC transporter activity
TP45_12485	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TP45_12490	COG1138	Cytochrome C-type biogenesis protein
TP45_12510	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TP45_12515	COG1278	Cold shock
TP45_12520	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TP45_12525	COG4988	ABC transporter
TP45_12535	COG1294	oxidase, subunit
TP45_12565	COG1476	TRANSCRIPTIONal
TP45_12570	COG0464	growth
TP45_12675	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TP45_12680	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TP45_12690	COG0165	Argininosuccinate lyase
TP45_12695	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TP45_12705	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TP45_12720	COG0137	argininosuccinate synthase activity
TP45_12725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TP45_12735	COG0215	cysteine-tRNA ligase activity
TP45_12740	COG2166	iron-sulfur cluster assembly
TP45_12750	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TP45_12760	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TP45_12765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TP45_12785	COG4302	ethanolamine ammonia-lyase activity
TP45_12835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TP45_12840	COG0402	S-adenosylhomocysteine deaminase activity
TP45_12850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TP45_12855	COG1509	lysine 2,3-aminomutase activity
TP45_12860	COG5001	Diguanylate cyclase
TP45_12860	COG3300	MHYT domain
TP45_12875	COG0483	inositol monophosphate 1-phosphatase activity
TP45_12900	COG0513	Belongs to the DEAD box helicase family
TP45_12905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TP45_12910	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TP45_12920	COG0625	glutathione transferase activity
TP45_12930	COG4681	YaeQ
TP45_12935	COG2081	HI0933 family
TP45_12945	COG0501	Belongs to the peptidase M48B family
TP45_12950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TP45_12955	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_12975	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TP45_12980	COG0860	N-Acetylmuramoyl-L-alanine amidase
TP45_12985	COG0802	atpase or kinase
TP45_12990	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TP45_12990	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TP45_12995	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TP45_13000	COG1570	exodeoxyribonuclease VII activity
TP45_13010	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TP45_13050	COG0835	chemotaxis
TP45_13055	COG0840	transmembrane signaling receptor activity
TP45_13060	COG2094	Belongs to the DNA glycosylase MPG family
TP45_13065	COG1201	RNA secondary structure unwinding
TP45_13080	COG2969	positive regulation of protein catabolic process
TP45_13085	COG0625	glutathione transferase activity
TP45_13090	COG2857	Cytochrome c1
TP45_13095	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TP45_13100	COG0723	plastoquinol--plastocyanin reductase activity
TP45_13105	COG0741	lytic transglycosylase activity
TP45_13120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TP45_13125	COG1702	phosphate starvation-inducible protein PhoH
TP45_13135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TP45_13145	COG4535	Mg2 and Co2 transporter CorC
TP45_13160	COG1012	belongs to the aldehyde dehydrogenase family
TP45_13170	COG1177	transmembrane transport
TP45_13175	COG1176	ABC-type spermidine putrescine transport system, permease component I
TP45_13180	COG3842	ATPase activity
TP45_13200	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TP45_13215	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TP45_13220	COG0174	glutamine synthetase
TP45_13225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP45_13230	COG0745	RESPONSE REGULATOR receiver
TP45_13230	COG3706	GGDEF domain
TP45_13235	COG2703	oxygen carrier activity
TP45_13240	COG0477	Major facilitator Superfamily
TP45_13255	COG0243	molybdopterin cofactor binding
TP45_13260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TP45_13280	COG2733	membrane
TP45_13285	COG0784	Response regulator, receiver
TP45_13285	COG2205	protein histidine kinase activity
TP45_13285	COG5002	protein histidine kinase activity
TP45_13295	COG0477	Major facilitator Superfamily
TP45_13325	COG2902	Dehydrogenase
TP45_13335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP45_13340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP45_13345	COG1609	Transcriptional regulator
TP45_13350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TP45_13350	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TP45_13355	COG1105	Belongs to the carbohydrate kinase PfkB family
TP45_13360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TP45_13360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TP45_13365	COG2801	Transposase and inactivated derivatives
TP45_13370	COG2963	transposase activity
TP45_13385	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TP45_13395	COG1862	Preprotein translocase
TP45_13400	COG0343	queuine tRNA-ribosyltransferase activity
TP45_13405	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TP45_13445	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TP45_13460	COG3291	Pkd domain containing protein
TP45_13470	COG0405	Gamma-glutamyltransferase
TP45_13475	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TP45_13490	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TP45_13495	COG0742	ribosomal rna small subunit methyltransferase
TP45_13500	COG0326	Molecular chaperone. Has ATPase activity
TP45_13530	COG3039	Transposase
TP45_13600	COG0531	amino acid
TP45_13615	COG0006	proline dipeptidase activity
TP45_13625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TP45_13640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP45_13645	COG3938	Belongs to the proline racemase family
TP45_13655	COG0552	protein localization to endoplasmic reticulum
TP45_13660	COG1194	a g-specific adenine glycosylase
TP45_13665	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TP45_13670	COG4191	Histidine kinase
TP45_13670	COG0784	Response regulator, receiver
TP45_13685	COG0322	excinuclease ABC activity
TP45_13700	COG3040	lipid binding
TP45_13710	COG1960	acyl-CoA dehydrogenase activity
TP45_13720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TP45_13740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TP45_13745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TP45_13750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TP45_13785	COG0438	transferase activity, transferring glycosyl groups
TP45_13790	COG0438	transferase activity, transferring glycosyl groups
TP45_13835	COG0776	regulation of translation
TP45_13840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TP45_13840	COG0072	phenylalanine-tRNA ligase activity
TP45_13845	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TP45_13850	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TP45_13855	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TP45_13860	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TP45_13865	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TP45_13910	COG3505	Type IV secretory pathway VirD4
TP45_13925	COG0556	nucleotide-excision repair
TP45_13935	COG3039	Transposase
TP45_13940	COG2801	Transposase and inactivated derivatives
TP45_13945	COG2963	transposase activity
TP45_13980	COG4969	Belongs to the N-Me-Phe pilin family
TP45_13985	COG1611	Belongs to the LOG family
TP45_13995	COG2095	MarC family integral membrane protein
TP45_14005	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TP45_14010	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TP45_14040	COG1185	polyribonucleotide nucleotidyltransferase activity
TP45_14045	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TP45_14050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TP45_14055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TP45_14060	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TP45_14065	COG0195	Participates in both transcription termination and antitermination
TP45_14070	COG0779	Required for maturation of 30S ribosomal subunits
TP45_14080	COG1007	ATP synthesis coupled electron transport
TP45_14095	COG0713	ATP synthesis coupled electron transport
TP45_14105	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TP45_14110	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TP45_14120	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TP45_14125	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TP45_14130	COG0649	NAD binding
TP45_14135	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TP45_14140	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TP45_14145	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TP45_14160	COG0149	triose-phosphate isomerase activity
TP45_14165	COG0300	oxidoreductase activity
TP45_14170	COG3039	Transposase
TP45_14205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TP45_14210	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TP45_14215	COG0159	tryptophan synthase activity
TP45_14225	COG0133	tryptophan synthase activity
TP45_14235	COG0135	phosphoribosylanthranilate isomerase activity
TP45_14240	COG0101	tRNA pseudouridine synthase activity
TP45_14260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TP45_14270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TP45_14275	COG2890	protein-(glutamine-N5) methyltransferase activity
TP45_14285	COG0688	phosphatidylethanolamine metabolic process
TP45_14295	COG0433	COG0433 Predicted ATPase
TP45_14300	COG0494	nUDIX hydrolase
TP45_14315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TP45_14320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TP45_14345	COG0717	Belongs to the dCTP deaminase family
TP45_14350	COG0489	protein tyrosine kinase activity
TP45_14370	COG3590	peptidase
TP45_14375	COG3590	peptidase
TP45_14395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TP45_14400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP45_14405	COG2311	Membrane
TP45_14410	COG1047	Peptidyl-prolyl cis-trans
TP45_14415	COG0791	NLP P60 protein
TP45_14420	COG0791	NLP P60 protein
TP45_14430	COG4106	trans-aconitate 2-methyltransferase activity
TP45_14435	COG1301	dicarboxylic acid transport
TP45_14440	COG1785	Belongs to the alkaline phosphatase family
TP45_14445	COG0037	tRNA processing
TP45_14450	COG1722	exodeoxyribonuclease VII activity
TP45_14455	COG0142	geranyltranstransferase activity
TP45_14470	COG0312	modulator of DNA gyrase
TP45_14475	COG3028	Belongs to the UPF0307 family
TP45_14480	COG0312	modulator of DNA gyrase
TP45_14490	COG3164	Protein of unknown function
TP45_14495	COG1530	ribonuclease E activity
TP45_14500	COG0424	maF-like protein
TP45_14505	COG2968	Membrane
TP45_14520	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TP45_14535	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TP45_14550	COG0495	leucyl-tRNA aminoacylation
TP45_14560	COG3118	belongs to the thioredoxin family
TP45_14595	COG2155	Conserved Protein
TP45_14600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TP45_14640	COG1132	(ABC) transporter
TP45_14665	COG0745	RESPONSE REGULATOR receiver
TP45_14670	COG5000	phosphorelay sensor kinase activity
TP45_14670	COG5002	protein histidine kinase activity
TP45_14675	COG0475	glutathione-regulated potassium exporter activity
TP45_14685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TP45_14705	COG3706	GGDEF domain
TP45_14710	COG1187	pseudouridine synthase activity
TP45_14715	COG5002	protein histidine kinase activity
TP45_14715	COG5001	Diguanylate cyclase
TP45_14830	COG0667	Aldo Keto reductase
TP45_14840	COG0583	DNA-binding transcription factor activity
TP45_14850	COG2207	Transcriptional regulator
TP45_14860	COG1309	transcriptional regulator
TP45_14885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP45_14905	COG0735	belongs to the Fur family
TP45_14910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TP45_14935	COG4452	Inner membrane protein CreD
TP45_14950	COG2205	protein histidine kinase activity
TP45_14955	COG0745	RESPONSE REGULATOR receiver
TP45_14960	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TP45_14975	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TP45_14985	COG0643	Histidine kinase
TP45_14985	COG2198	Histidine kinase
TP45_14990	COG0840	transmembrane signaling receptor activity
TP45_14995	COG0835	chemotaxis
TP45_15000	COG2199	diguanylate cyclase activity
TP45_15000	COG2200	EAL domain
TP45_15000	COG2202	Pas domain
TP45_15005	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TP45_15010	COG2201	protein-glutamate methylesterase activity
TP45_15015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP45_15020	COG3590	peptidase
TP45_15030	COG0588	phosphoglycerate mutase activity
TP45_15035	COG1515	deoxyribonuclease V activity
TP45_15045	COG1741	Belongs to the pirin family
TP45_15060	COG1741	Belongs to the pirin family
TP45_15065	COG1966	Carbon starvation protein
TP45_15070	COG2879	small protein
TP45_15120	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TP45_15125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TP45_15130	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TP45_15135	COG2080	2 iron, 2 sulfur cluster binding
TP45_15140	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_15140	COG0604	alcohol dehydrogenase
TP45_15140	COG3321	synthase
TP45_15145	COG4251	negative regulation of phosphorylation
TP45_15145	COG5001	Diguanylate cyclase
TP45_15145	COG3706	GGDEF domain
TP45_15145	COG2203	Gaf domain
TP45_15150	COG0629	single-stranded DNA binding
TP45_15155	COG0142	geranyltranstransferase activity
TP45_15165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TP45_15180	COG0527	aspartate kinase activity
TP45_15185	COG0384	phenazine biosynthesis protein PhzF
TP45_15190	COG0384	phenazine biosynthesis protein PhzF
TP45_15200	COG1764	response to oxidative stress
TP45_15205	COG0540	Belongs to the ATCase OTCase family
TP45_15210	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TP45_15215	COG1678	Uncharacterized ACR, COG1678
TP45_15225	COG0519	Catalyzes the synthesis of GMP from XMP
TP45_15250	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TP45_15265	COG0739	heme binding
TP45_15285	COG0693	protein deglycase activity
TP45_15295	COG1959	2 iron, 2 sulfur cluster binding
TP45_15300	COG0719	Fe-S assembly protein
TP45_15305	COG0396	ATPase activity
TP45_15310	COG0719	Fe-S assembly protein
TP45_15315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TP45_15330	COG4774	siderophore transport
TP45_15335	COG3128	pkhd-type hydroxylase
TP45_15360	COG1477	protein flavinylation
TP45_15365	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TP45_15375	COG1555	photosystem II stabilization
TP45_15390	COG3178	'Phosphotransferase
TP45_15395	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TP45_15405	COG0628	permease
TP45_15415	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TP45_15425	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TP45_15445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TP45_15450	COG0271	Belongs to the BolA IbaG family
TP45_15460	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TP45_15470	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
TP45_15475	COG1137	ATPase activity
TP45_15490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TP45_15495	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TP45_15500	COG1660	Displays ATPase and GTPase activities
TP45_15510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TP45_15515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TP45_15520	COG2239	Acts as a magnesium transporter
TP45_15530	COG1294	oxidase, subunit
TP45_15535	COG1271	oxidase subunit
TP45_15545	COG1113	amino acid transport
TP45_15565	COG2197	response regulator
TP45_15570	COG0531	amino acid
TP45_15645	COG2814	Major facilitator Superfamily
TP45_15655	COG0754	glutathionylspermidine amidase activity
TP45_15680	COG1842	Phage shock protein A
TP45_15690	COG0259	pyridoxamine-phosphate oxidase activity
TP45_15695	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TP45_15700	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TP45_15710	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TP45_15715	COG0477	Major facilitator Superfamily
TP45_15750	COG0784	Response regulator, receiver
TP45_15750	COG2205	protein histidine kinase activity
TP45_15750	COG2198	Histidine kinase
TP45_15755	COG2353	YceI-like domain
TP45_15775	COG1760	l-serine dehydratase
TP45_15790	COG0527	aspartate kinase activity
TP45_15790	COG0460	homoserine dehydrogenase
TP45_15795	COG0626	cystathionine gamma-synthase activity
TP45_15800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TP45_15805	COG0739	heme binding
TP45_15810	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TP45_15815	COG1272	protein, Hemolysin III
TP45_15820	COG2982	Protein involved in outer membrane biogenesis
TP45_15825	COG0517	IMP dehydrogenase activity
TP45_15825	COG0516	GMP reductase activity
TP45_15830	COG0463	Glycosyl transferase, family 2
TP45_15835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TP45_15840	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TP45_15850	COG4771	TonB-dependent receptor
TP45_15855	COG1309	transcriptional regulator
TP45_15860	COG2267	carboxylic ester hydrolase activity
TP45_15865	COG1960	acyl-CoA dehydrogenase activity
TP45_15895	COG0509	glycine decarboxylation via glycine cleavage system
TP45_15900	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TP45_15910	COG1742	UPF0060 membrane protein
TP45_15915	COG3956	TIGRFAM MazG family protein
TP45_15920	COG1218	3'(2'),5'-bisphosphate nucleotidase
TP45_15925	COG0494	nUDIX hydrolase
TP45_15935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TP45_15940	COG0837	glucose binding
TP45_15955	COG3858	chitin binding
TP45_15955	COG1388	LysM domain
TP45_15960	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TP45_15970	COG1472	Belongs to the glycosyl hydrolase 3 family
TP45_15990	COG1486	melibiose metabolic process
TP45_16000	COG3537	Alpha-1,2-mannosidase
TP45_16035	COG3142	Participates in the control of copper homeostasis
TP45_16040	COG1446	asparaginase
TP45_16075	COG0840	transmembrane signaling receptor activity
TP45_16080	COG0835	chemotaxis
TP45_16095	COG0189	ligase activity
TP45_16115	COG1199	ATP-dependent helicase activity
TP45_16125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TP45_16130	COG1442	glycosyl transferase family 8
TP45_16130	COG1216	Glycosyl transferase, family 2
TP45_16140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TP45_16145	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TP45_16150	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
TP45_16155	COG0535	radical SAM domain protein
TP45_16160	COG0535	radical SAM domain protein
TP45_16175	COG0837	glucose binding
TP45_16185	COG1643	Atp-dependent helicase
TP45_16190	COG0783	Belongs to the Dps family
TP45_16195	COG0514	ATP-dependent DNA helicase (RecQ)
TP45_16230	COG0840	transmembrane signaling receptor activity
TP45_16250	COG3920	Histidine kinase
TP45_16265	COG0602	queuosine metabolic process
TP45_16275	COG2885	chlorophyll binding
TP45_16280	COG0823	Involved in the tonB-independent uptake of proteins
TP45_16290	COG0848	biopolymer transport protein
TP45_16300	COG0824	Thioesterase
TP45_16305	COG2255	four-way junction helicase activity
TP45_16310	COG3158	transport of potassium into the cell
TP45_16315	COG0632	four-way junction helicase activity
TP45_16320	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TP45_16325	COG0217	transcriptional regulatory protein
TP45_16340	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TP45_16355	COG0477	Major facilitator Superfamily
TP45_16400	COG0488	(ABC) transporter
TP45_16430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TP45_16430	COG4651	solute:proton antiporter activity
TP45_16440	COG4772	TonB-dependent receptor
TP45_16450	COG4264	IucA IucC family
TP45_16465	COG0019	diaminopimelate decarboxylase activity
TP45_16510	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TP45_16520	COG1492	cobalamin metabolic process
TP45_16530	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TP45_16555	COG4206	TonB-dependent receptor
TP45_16565	COG0542	response to heat
TP45_16575	COG1116	anion transmembrane transporter activity
TP45_16580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TP45_16590	COG0667	Aldo Keto reductase
TP45_16605	COG4771	TonB-dependent receptor
TP45_16610	COG2827	Endonuclease containing a URI domain
TP45_16650	COG1877	trehalose-phosphatase activity
TP45_16655	COG3387	PFAM Glycoside hydrolase 15-related
TP45_16670	COG0840	transmembrane signaling receptor activity
TP45_16675	COG3011	Protein conserved in bacteria
TP45_16690	COG0564	pseudouridine synthase activity
TP45_16695	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TP45_16705	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TP45_16705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TP45_16715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TP45_16720	COG0045	succinate-CoA ligase (ADP-forming) activity
TP45_16740	COG4969	Belongs to the N-Me-Phe pilin family
TP45_16755	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TP45_16760	COG0237	dephospho-CoA kinase activity
TP45_16765	COG3039	Transposase
TP45_16770	COG2801	Transposase and inactivated derivatives
TP45_16775	COG2963	transposase activity
TP45_16790	COG0745	RESPONSE REGULATOR receiver
TP45_16800	COG0189	ligase activity
TP45_16840	COG2801	Transposase and inactivated derivatives
TP45_16845	COG2963	transposase activity
TP45_16870	COG2022	thiamine diphosphate biosynthetic process
TP45_16875	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TP45_16880	COG0471	metal ion transport
TP45_16880	COG3273	potassium ion transport
TP45_16905	COG1970	mechanosensitive ion channel activity
TP45_16920	COG1609	Transcriptional regulator
TP45_16930	COG3250	beta-galactosidase activity
TP45_16935	COG4948	Mandelate Racemase Muconate Lactonizing
TP45_16950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TP45_16960	COG0308	aminopeptidase N
TP45_16985	COG2963	transposase activity
TP45_16990	COG2801	Transposase and inactivated derivatives
TP45_17020	COG3039	Transposase
TP45_17025	COG2801	Transposase and inactivated derivatives
TP45_17030	COG2963	transposase activity
TP45_17045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP45_17050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP45_17055	COG0529	Catalyzes the synthesis of activated sulfate
TP45_17055	COG2895	sulfate adenylyltransferase (ATP) activity
TP45_17060	COG0175	sulfate reduction
TP45_17065	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TP45_17070	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TP45_17075	COG0175	sulfate reduction
TP45_17130	COG3588	fructose-bisphosphate aldolase
TP45_17135	COG0469	pyruvate kinase activity
TP45_17145	COG0126	phosphoglycerate kinase activity
TP45_17165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TP45_17175	COG3047	cAMP biosynthetic process
TP45_17190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TP45_17190	COG3453	Protein conserved in bacteria
TP45_17195	COG0725	ABC transporter, periplasmic molybdate-binding protein
TP45_17200	COG4149	molybdate abc transporter
TP45_17205	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TP45_17240	COG1376	ErfK ybiS ycfS ynhG family protein
TP45_17245	COG0739	heme binding
TP45_17250	COG4773	Receptor
TP45_17285	COG3039	Transposase
TP45_17290	COG3039	Transposase
TP45_17295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TP45_17310	COG2304	oxidoreductase activity
TP45_17330	COG0714	Associated with various cellular activities
TP45_17360	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TP45_17375	COG0254	rRNA binding
TP45_17385	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TP45_17395	COG2721	sulfolactate sulfo-lyase activity
TP45_17410	COG2271	Major facilitator Superfamily
TP45_17425	COG0583	DNA-binding transcription factor activity
TP45_17430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TP45_17435	COG1758	RNA polymerase activity
TP45_17445	COG1561	YicC-like family, N-terminal region
TP45_17450	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TP45_17460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TP45_17465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TP45_17480	COG0006	proline dipeptidase activity
TP45_17485	COG0006	proline dipeptidase activity
TP45_17490	COG3079	Belongs to the UPF0149 family
TP45_17505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TP45_17515	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TP45_17525	COG2912	Transglutaminase-like superfamily
TP45_17530	COG1773	rubredoxin
TP45_17535	COG0352	thiamine-phosphate diphosphorylase activity
TP45_17545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TP45_17560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TP45_17590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TP45_17595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TP45_17600	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_17610	COG0671	phosphoesterase, PA-phosphatase related
TP45_17615	COG3781	membrane
TP45_17625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TP45_17630	COG0563	adenylate kinase activity
TP45_17645	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TP45_17655	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TP45_17675	COG3710	Transcriptional regulator
TP45_17680	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TP45_17690	COG0840	transmembrane signaling receptor activity
TP45_17700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TP45_17720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TP45_17725	COG0473	3-isopropylmalate dehydrogenase activity
TP45_17730	COG0066	3-isopropylmalate dehydratase activity
TP45_17735	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TP45_17755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TP45_17760	COG1538	Outer membrane efflux protein
TP45_17765	COG1519	Transferase
TP45_17770	COG1560	Kdo2-lipid A biosynthetic process
TP45_17805	COG2963	transposase activity
TP45_17810	COG2801	Transposase and inactivated derivatives
TP45_17830	COG2801	Transposase and inactivated derivatives
TP45_17835	COG2963	transposase activity
TP45_17840	COG3039	Transposase
TP45_17845	COG0436	Aminotransferase
TP45_17860	COG0726	polysaccharide deacetylase
TP45_17865	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TP45_17880	COG3964	amidohydrolase
TP45_17885	COG0402	S-adenosylhomocysteine deaminase activity
TP45_17905	COG1307	EDD domain protein, DegV family
TP45_17910	COG0242	peptide deformylase activity
TP45_17935	COG0457	Tetratricopeptide repeat
TP45_17940	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
TP45_17945	COG1215	transferase activity, transferring glycosyl groups
TP45_17950	COG1215	transferase activity, transferring glycosyl groups
TP45_17965	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TP45_18015	COG2188	Transcriptional regulator
TP45_18025	COG1450	Type ii and iii secretion system protein
TP45_18040	COG3166	PFAM Fimbrial assembly family protein
TP45_18045	COG3156	type II secretion system protein K
TP45_18050	COG4795	General secretion pathway protein
TP45_18055	COG2165	general secretion pathway protein
TP45_18060	COG4970	Tfp pilus assembly protein FimT
TP45_18065	COG2165	general secretion pathway protein
TP45_18070	COG1459	type II secretion system
TP45_18075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TP45_18080	COG1404	Belongs to the peptidase S8 family
TP45_18090	COG3039	Transposase
TP45_18105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TP45_18105	COG0047	phosphoribosylformylglycinamidine synthase activity
TP45_18110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TP45_18115	COG4974	Belongs to the 'phage' integrase family
TP45_18130	COG0795	lipopolysaccharide-transporting ATPase activity
TP45_18140	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TP45_18155	COG0525	valine-tRNA ligase activity
TP45_18165	COG0741	lytic transglycosylase activity
TP45_18185	COG1183	phosphatidylcholine synthase activity
TP45_18195	COG0442	prolyl-tRNA aminoacylation
TP45_18250	COG5489	Protein of unknown function (DUF736)
TP45_18280	COG1192	Involved in chromosome partitioning
TP45_18310	COG2814	Major facilitator Superfamily
TP45_18335	COG0446	pyridine nucleotide-disulphide oxidoreductase
TP45_18335	COG1902	pentaerythritol trinitrate reductase activity
TP45_18340	COG0583	DNA-binding transcription factor activity
TP45_18360	COG4962	Type ii secretion system protein e
TP45_18365	COG3838	Conjugal transfer protein Trbc
TP45_18375	COG3451	type IV secretory pathway VirB4
TP45_18415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TP45_18415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TP45_18445	COG1595	DNA-templated transcription, initiation
TP45_18470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TP45_18485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TP45_18490	COG0251	oxidation-reduction process
TP45_18500	COG0392	lysyltransferase activity
TP45_18500	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TP45_18535	COG2814	Major facilitator Superfamily
TP45_18540	COG1902	pentaerythritol trinitrate reductase activity
TP45_18545	COG2824	Alkylphosphonate utilization operon protein PhnA
TP45_18555	COG1047	Peptidyl-prolyl cis-trans
TP45_18560	COG1077	Cell shape determining protein MreB Mrl
TP45_18580	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TP45_18590	COG5487	UPF0391 membrane protein
TP45_18595	COG1451	nucleotide metabolic process
TP45_18610	COG0183	Belongs to the thiolase family
TP45_18640	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TP45_18640	COG1793	dna ligase
TP45_18650	COG1793	dna ligase
TP45_18655	COG1201	RNA secondary structure unwinding
TP45_18665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TP45_18670	COG1278	Cold shock
TP45_18675	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TP45_18685	COG1472	Belongs to the glycosyl hydrolase 3 family
TP45_18690	COG3046	protein related to deoxyribodipyrimidine photolyase
TP45_18695	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
TP45_18700	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TP45_18710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TP45_18720	COG1381	Involved in DNA repair and RecF pathway recombination
TP45_18725	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TP45_18730	COG0571	ribonuclease III activity
TP45_18745	COG0481	GTPase activity
TP45_18750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TP45_18765	COG1250	3-hydroxyacyl-CoA dehydrogenase
TP45_18765	COG1024	Enoyl-CoA hydratase
TP45_18785	COG1166	arginine decarboxylase activity
TP45_18790	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TP45_18830	COG0606	chelatase, subunit chli
TP45_18845	COG4943	cyclic-guanylate-specific phosphodiesterase activity
TP45_18880	COG1690	Belongs to the RtcB family
TP45_18925	COG0745	RESPONSE REGULATOR receiver
TP45_18930	COG0642	Histidine kinase
TP45_18955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TP45_18980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TP45_18985	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TP45_18995	COG0753	catalase activity
TP45_19010	COG2197	response regulator
TP45_19015	COG4585	Histidine kinase
TP45_19020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP45_19025	COG1136	(ABC) transporter
TP45_19050	COG0697	spore germination
TP45_19065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TP45_19070	COG0180	Tryptophanyl-tRNA synthetase
TP45_19075	COG3237	CsbD-like
TP45_19115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TP45_19130	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TP45_19135	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TP45_19135	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TP45_19160	COG2205	protein histidine kinase activity
TP45_19165	COG0745	RESPONSE REGULATOR receiver
TP45_19175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TP45_19200	COG1199	ATP-dependent helicase activity
TP45_19215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TP45_19280	COG0625	glutathione transferase activity
TP45_19315	COG4555	ABC transporter
TP45_19325	COG1476	TRANSCRIPTIONal
TP45_19345	COG1230	cation diffusion facilitator family transporter
TP45_19350	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TP45_19355	COG1131	(ABC) transporter
TP45_19360	COG0842	Transport permease protein
TP45_19365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TP45_19395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TP45_19405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TP45_19415	COG0045	succinate-CoA ligase (ADP-forming) activity
TP45_19415	COG1042	CoA-binding domain protein
TP45_19415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TP45_19420	COG2239	Acts as a magnesium transporter
TP45_19435	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TP45_19440	COG3387	PFAM Glycoside hydrolase 15-related
TP45_19450	COG3100	YcgL domain-containing protein
TP45_19455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TP45_19465	COG0463	Glycosyl transferase, family 2
TP45_19475	COG3039	Transposase
TP45_19480	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_19520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TP45_19535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TP45_19560	COG4946	Tricorn protease homolog
TP45_19560	COG0823	Involved in the tonB-independent uptake of proteins
TP45_19560	COG1506	peptidase
TP45_19575	COG0408	coproporphyrinogen oxidase activity
TP45_19610	COG2815	serine threonine protein kinase
TP45_19610	COG0515	serine threonine protein kinase
TP45_19615	COG0631	protein serine/threonine phosphatase activity
TP45_19640	COG0667	Aldo Keto reductase
TP45_19645	COG0583	DNA-binding transcription factor activity
TP45_19660	COG3501	Rhs element vgr protein
TP45_19685	COG1595	DNA-templated transcription, initiation
TP45_19715	COG2801	Transposase and inactivated derivatives
TP45_19720	COG2963	transposase activity
TP45_19750	COG1082	Xylose isomerase domain protein TIM barrel
TP45_19770	COG2801	Transposase and inactivated derivatives
TP45_19775	COG2963	transposase activity
TP45_19780	COG3039	Transposase
TP45_19790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TP45_19790	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TP45_19800	COG0366	Alpha amylase catalytic
TP45_19805	COG0366	Alpha amylase catalytic
TP45_19810	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TP45_19830	COG2755	lipolytic protein G-D-S-L family
TP45_19830	COG0657	acetylesterase activity
TP45_19840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TP45_19855	COG3507	Belongs to the glycosyl hydrolase 43 family
TP45_19860	COG1609	Transcriptional regulator
TP45_19865	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TP45_19870	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_19880	COG2755	lipolytic protein G-D-S-L family
TP45_19890	COG3186	Phenylalanine-4-hydroxylase
TP45_19895	COG1522	sequence-specific DNA binding
TP45_19905	COG1752	Esterase of the alpha-beta hydrolase superfamily
TP45_19915	COG1119	ATPase activity
TP45_19930	COG1125	glycine betaine transport
TP45_19930	COG0517	IMP dehydrogenase activity
TP45_19945	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TP45_19980	COG0489	protein tyrosine kinase activity
TP45_19985	COG2062	phosphohistidine phosphatase, SixA
TP45_19995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP45_20040	COG1968	undecaprenyl-diphosphatase activity
TP45_20045	COG0174	glutamine synthetase
TP45_20050	COG0347	Belongs to the P(II) protein family
TP45_20055	COG0004	ammonium transporteR
TP45_20060	COG3852	Histidine kinase
TP45_20065	COG2204	response regulator
TP45_20070	COG2032	superoxide dismutase activity
TP45_20075	COG2032	superoxide dismutase activity
TP45_20080	COG0346	lactoylglutathione lyase activity
TP45_20090	COG0183	Belongs to the thiolase family
TP45_20125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TP45_20130	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TP45_20135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TP45_20155	COG0028	Belongs to the TPP enzyme family
TP45_20160	COG2205	protein histidine kinase activity
TP45_20185	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TP45_20200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TP45_20210	COG0596	Alpha beta hydrolase
TP45_20220	COG0318	PFAM AMP-dependent synthetase and ligase
TP45_20235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TP45_20260	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TP45_20270	COG0564	pseudouridine synthase activity
TP45_20290	COG1446	asparaginase
TP45_20295	COG0339	signal peptide processing
TP45_20330	COG0475	glutathione-regulated potassium exporter activity
TP45_20335	COG0583	DNA-binding transcription factor activity
TP45_20340	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TP45_20345	COG2224	Isocitrate lyase
TP45_20350	COG3706	GGDEF domain
TP45_20375	COG2801	Transposase and inactivated derivatives
TP45_20380	COG2963	transposase activity
TP45_20395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TP45_20400	COG1960	acyl-CoA dehydrogenase activity
TP45_20470	COG0697	spore germination
TP45_20480	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TP45_20485	COG1846	Transcriptional regulator
TP45_20490	COG1764	response to oxidative stress
TP45_20520	COG2130	NADP-dependent
TP45_20535	COG1187	pseudouridine synthase activity
TP45_20550	COG1643	Atp-dependent helicase
TP45_20555	COG4807	Protein conserved in bacteria
TP45_20560	COG2351	hydroxyisourate hydrolase activity
TP45_20565	COG2072	flavoprotein involved in K transport
TP45_20585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TP45_20595	COG0583	DNA-binding transcription factor activity
TP45_20630	COG2252	PERMEase
TP45_20655	COG0084	hydrolase, TatD family'
TP45_20665	COG0583	DNA-binding transcription factor activity
TP45_20670	COG2814	Major facilitator Superfamily
TP45_20680	COG2267	carboxylic ester hydrolase activity
TP45_20685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TP45_20690	COG1902	pentaerythritol trinitrate reductase activity
TP45_20710	COG0745	RESPONSE REGULATOR receiver
TP45_20715	COG2205	protein histidine kinase activity
TP45_20720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP45_20740	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TP45_20745	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TP45_20750	COG0583	DNA-binding transcription factor activity
TP45_20785	COG0702	epimerase
TP45_20790	COG1733	regulation of RNA biosynthetic process
TP45_20825	COG0129	dihydroxy-acid dehydratase activity
TP45_20845	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TP45_20900	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TP45_20905	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TP45_20930	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TP45_20935	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TP45_20945	COG3485	protocatechuate 3,4-dioxygenase
TP45_20950	COG3485	protocatechuate 3,4-dioxygenase
TP45_20960	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TP45_20965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TP45_20975	COG1414	Transcriptional regulator
TP45_21000	COG0445	tRNA wobble uridine modification
TP45_21035	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_21040	COG2267	carboxylic ester hydrolase activity
TP45_21050	COG0156	8-amino-7-oxononanoate synthase activity
TP45_21055	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TP45_21060	COG1040	competence protein
TP45_21065	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TP45_21100	COG2963	transposase activity
TP45_21105	COG2801	Transposase and inactivated derivatives
TP45_21120	COG0604	alcohol dehydrogenase
TP45_21120	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_21120	COG3321	synthase
TP45_21125	COG2937	Belongs to the GPAT DAPAT family
TP45_21160	COG0284	orotidine-5'-phosphate decarboxylase activity
TP45_21165	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
TP45_21170	COG3132	Protein of unknown function, DUF480
TP45_21185	COG0210	DNA helicase
TP45_21190	COG1435	thymidine kinase activity
TP45_21200	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
TP45_21210	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TP45_21240	COG3135	benzoate transporter
TP45_21260	COG0676	glucose-6-phosphate 1-epimerase activity
TP45_21270	COG3012	SEC-C Motif Domain Protein
TP45_21275	COG0730	response to heat
TP45_21295	COG0302	gtp cyclohydrolase
TP45_21310	COG1566	PFAM secretion protein HlyD family protein
TP45_21320	COG1289	transmembrane transporter activity
TP45_21325	COG0477	Major facilitator Superfamily
TP45_21335	COG0583	DNA-binding transcription factor activity
TP45_21340	COG4221	oxidoreductase activity
TP45_21350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP45_21410	COG0439	Biotin carboxylase
TP45_21435	COG1028	Short-chain dehydrogenase reductase Sdr
TP45_21465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TP45_21470	COG1074	ATP-dependent DNA helicase activity
TP45_21475	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TP45_21510	COG1127	ABC transporter
TP45_21515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TP45_21520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TP45_21535	COG2853	Lipoprotein
TP45_21545	COG0386	Belongs to the glutathione peroxidase family
TP45_21555	COG1322	Protein conserved in bacteria
TP45_21565	COG0625	glutathione transferase activity
TP45_21575	COG0531	amino acid
TP45_21590	COG3835	regulator
TP45_21595	COG1929	Belongs to the glycerate kinase type-1 family
TP45_21600	COG2271	Major facilitator Superfamily
TP45_21615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TP45_21620	COG0861	Integral membrane protein TerC family
TP45_21630	COG0584	glycerophosphoryl diester phosphodiesterase
TP45_21645	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TP45_21655	COG0706	membrane insertase activity
TP45_21660	COG0594	ribonuclease P activity
TP45_21665	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TP45_21705	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TP45_21720	COG2337	Toxic component of a toxin-antitoxin (TA) module
TP45_21750	COG3077	Addiction module antitoxin, RelB DinJ family
TP45_21755	COG3041	Addiction module toxin RelE StbE family
TP45_21815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP45_21835	COG2948	multi-organism process
TP45_21840	COG3504	Conjugal transfer protein
TP45_21850	COG3704	protein secretion by the type IV secretion system