locus-tag	class	description
TP50_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TP50_00015	COG2963	transposase activity
TP50_00020	COG2801	Transposase and inactivated derivatives
TP50_00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TP50_00030	COG0187	DNA topoisomerase II activity
TP50_00040	COG0501	Belongs to the peptidase M48B family
TP50_00075	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TP50_00085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP50_00130	COG0793	Belongs to the peptidase S41A family
TP50_00135	COG4942	peptidase
TP50_00145	COG2234	aminopeptidase activity
TP50_00165	COG2801	Transposase and inactivated derivatives
TP50_00170	COG2963	transposase activity
TP50_00195	COG0493	'glutamate synthase
TP50_00200	COG0070	glutamate synthase
TP50_00200	COG0069	glutamate synthase activity
TP50_00200	COG0067	glutamate synthase
TP50_00285	COG1111	helicase
TP50_00285	COG1205	dead DEAH box helicase
TP50_00290	COG1272	protein, Hemolysin III
TP50_00305	COG0300	oxidoreductase activity
TP50_00310	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_00335	COG2963	transposase activity
TP50_00340	COG2801	Transposase and inactivated derivatives
TP50_00355	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TP50_00365	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TP50_00370	COG1064	alcohol dehydrogenase
TP50_00375	COG2963	transposase activity
TP50_00380	COG2801	Transposase and inactivated derivatives
TP50_00410	COG0714	Associated with various cellular activities
TP50_00455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TP50_00510	COG3237	CsbD-like
TP50_00525	COG2801	Transposase and inactivated derivatives
TP50_00530	COG2963	transposase activity
TP50_00540	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TP50_00550	COG4772	TonB-dependent receptor
TP50_00565	COG1012	belongs to the aldehyde dehydrogenase family
TP50_00590	COG1304	FMN binding
TP50_00600	COG4585	Histidine kinase
TP50_00605	COG2197	response regulator
TP50_00625	COG3710	Transcriptional regulator
TP50_00630	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TP50_00660	COG3039	Transposase
TP50_00680	COG0366	Alpha amylase catalytic
TP50_00685	COG0366	Alpha amylase catalytic
TP50_00690	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TP50_00720	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TP50_00735	COG3507	Belongs to the glycosyl hydrolase 43 family
TP50_00740	COG1609	Transcriptional regulator
TP50_00745	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TP50_00750	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_00760	COG2755	lipolytic protein G-D-S-L family
TP50_00770	COG3186	Phenylalanine-4-hydroxylase
TP50_00775	COG1522	sequence-specific DNA binding
TP50_00785	COG1752	Esterase of the alpha-beta hydrolase superfamily
TP50_00795	COG1119	ATPase activity
TP50_00810	COG1125	glycine betaine transport
TP50_00810	COG0517	IMP dehydrogenase activity
TP50_00825	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TP50_00865	COG0489	protein tyrosine kinase activity
TP50_00870	COG2062	phosphohistidine phosphatase, SixA
TP50_00880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP50_00925	COG1968	undecaprenyl-diphosphatase activity
TP50_00930	COG0174	glutamine synthetase
TP50_00935	COG0347	Belongs to the P(II) protein family
TP50_00940	COG0004	ammonium transporteR
TP50_00945	COG3852	Histidine kinase
TP50_00950	COG2204	response regulator
TP50_00955	COG2032	superoxide dismutase activity
TP50_00960	COG2032	superoxide dismutase activity
TP50_00965	COG0346	lactoylglutathione lyase activity
TP50_00975	COG0183	Belongs to the thiolase family
TP50_01010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TP50_01015	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TP50_01020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TP50_01040	COG0028	Belongs to the TPP enzyme family
TP50_01045	COG2205	protein histidine kinase activity
TP50_01070	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TP50_01085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TP50_01095	COG0596	Alpha beta hydrolase
TP50_01105	COG0318	PFAM AMP-dependent synthetase and ligase
TP50_01120	COG3039	Transposase
TP50_01130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TP50_01150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TP50_01160	COG0564	pseudouridine synthase activity
TP50_01185	COG0339	signal peptide processing
TP50_01220	COG0475	glutathione-regulated potassium exporter activity
TP50_01225	COG0583	DNA-binding transcription factor activity
TP50_01230	COG3039	Transposase
TP50_01235	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TP50_01240	COG2224	Isocitrate lyase
TP50_01245	COG3706	GGDEF domain
TP50_01265	COG3039	Transposase
TP50_01285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TP50_01290	COG1960	acyl-CoA dehydrogenase activity
TP50_01360	COG0697	spore germination
TP50_01370	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TP50_01375	COG1846	Transcriptional regulator
TP50_01380	COG1764	response to oxidative stress
TP50_01410	COG2130	NADP-dependent
TP50_01425	COG1187	pseudouridine synthase activity
TP50_01440	COG1643	Atp-dependent helicase
TP50_01445	COG4807	Protein conserved in bacteria
TP50_01450	COG2351	hydroxyisourate hydrolase activity
TP50_01455	COG2072	flavoprotein involved in K transport
TP50_01475	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TP50_01485	COG0583	DNA-binding transcription factor activity
TP50_01520	COG2252	PERMEase
TP50_01540	COG0084	hydrolase, TatD family'
TP50_01550	COG0583	DNA-binding transcription factor activity
TP50_01555	COG2814	Major facilitator Superfamily
TP50_01565	COG2267	carboxylic ester hydrolase activity
TP50_01570	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TP50_01575	COG1902	pentaerythritol trinitrate reductase activity
TP50_01595	COG0745	RESPONSE REGULATOR receiver
TP50_01600	COG2205	protein histidine kinase activity
TP50_01605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP50_01625	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TP50_01630	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TP50_01635	COG0583	DNA-binding transcription factor activity
TP50_01670	COG0702	epimerase
TP50_01675	COG1733	regulation of RNA biosynthetic process
TP50_01710	COG2963	transposase activity
TP50_01715	COG2801	Transposase and inactivated derivatives
TP50_01730	COG0129	dihydroxy-acid dehydratase activity
TP50_01750	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TP50_01805	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TP50_01810	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TP50_01835	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TP50_01840	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TP50_01850	COG3485	protocatechuate 3,4-dioxygenase
TP50_01855	COG3485	protocatechuate 3,4-dioxygenase
TP50_01870	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TP50_01880	COG1414	Transcriptional regulator
TP50_01900	COG0445	tRNA wobble uridine modification
TP50_01935	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_01940	COG2267	carboxylic ester hydrolase activity
TP50_01950	COG0156	8-amino-7-oxononanoate synthase activity
TP50_01955	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TP50_01960	COG1040	competence protein
TP50_01965	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TP50_01975	COG0582	viral genome integration into host DNA
TP50_01985	COG2963	transposase activity
TP50_01990	COG2801	Transposase and inactivated derivatives
TP50_02035	COG5297	Belongs to the glycosyl hydrolase family 6
TP50_02090	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TP50_02140	COG3039	Transposase
TP50_02165	COG1511	domain protein
TP50_02165	COG3264	Mechanosensitive ion channel
TP50_02170	COG1368	sulfuric ester hydrolase activity
TP50_02175	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TP50_02180	COG2354	Protein conserved in bacteria
TP50_02185	COG0745	RESPONSE REGULATOR receiver
TP50_02185	COG3706	GGDEF domain
TP50_02190	COG0297	glycogen (starch) synthase activity
TP50_02195	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TP50_02200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TP50_02225	COG0702	epimerase
TP50_02230	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_02265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP50_02270	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_02280	COG0513	Belongs to the DEAD box helicase family
TP50_02285	COG0508	dehydrogenase complex catalyzes the overall conversion of
TP50_02300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TP50_02310	COG3483	tryptophan 2,3-dioxygenase activity
TP50_02315	COG3104	oligopeptide transport
TP50_02350	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
TP50_02365	COG1320	monovalent cation:proton antiporter activity
TP50_02370	COG2212	antiporter activity
TP50_02380	COG0651	ATP synthesis coupled electron transport
TP50_02385	COG1006	Multisubunit Na H antiporter MnhC subunit
TP50_02390	COG2111	Na H antiporter
TP50_02390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TP50_02415	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TP50_02420	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TP50_02435	COG0456	acetyltransferase
TP50_02440	COG1597	lipid kinase activity
TP50_02465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TP50_02470	COG0134	indole-3-glycerol-phosphate synthase activity
TP50_02480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TP50_02485	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TP50_02495	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TP50_02500	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TP50_02505	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TP50_02520	COG1051	belongs to the nudix hydrolase family
TP50_02560	COG0316	Belongs to the HesB IscA family
TP50_02580	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TP50_02595	COG2814	Major facilitator Superfamily
TP50_02605	COG2814	Major facilitator Superfamily
TP50_02610	COG1289	transmembrane transporter activity
TP50_02620	COG0151	Belongs to the GarS family
TP50_02630	COG0138	bifunctional purine biosynthesis protein purh
TP50_02635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TP50_02640	COG2267	carboxylic ester hydrolase activity
TP50_02645	COG2453	phosphatase
TP50_02645	COG0671	phosphoesterase, PA-phosphatase related
TP50_02670	COG4589	Belongs to the CDS family
TP50_02675	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
TP50_02700	COG2264	protein methyltransferase activity
TP50_02715	COG0439	Biotin carboxylase
TP50_02725	COG0511	ligase activity, forming carbon-carbon bonds
TP50_02730	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TP50_02740	COG1324	tolerance protein
TP50_02750	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TP50_02755	COG0459	protein refolding
TP50_02770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TP50_02785	COG3386	PFAM SMP-30 Gluconolaconase
TP50_02795	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TP50_02815	COG3039	Transposase
TP50_02860	COG0778	Nitroreductase
TP50_02865	COG2353	YceI-like domain
TP50_02895	COG3052	prosthetic group binding
TP50_02915	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
TP50_02930	COG1802	Transcriptional regulator
TP50_02965	COG3039	Transposase
TP50_02980	COG3039	Transposase
TP50_02995	COG2963	transposase activity
TP50_03000	COG2801	Transposase and inactivated derivatives
TP50_03005	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
TP50_03010	COG0025	NhaP-type Na H and K H
TP50_03015	COG1131	(ABC) transporter
TP50_03020	COG0842	Transport permease protein
TP50_03070	COG1522	sequence-specific DNA binding
TP50_03075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP50_03080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TP50_03100	COG2202	Pas domain
TP50_03100	COG2205	protein histidine kinase activity
TP50_03120	COG2813	Specifically methylates the guanine in position
TP50_03125	COG1187	pseudouridine synthase activity
TP50_03130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TP50_03165	COG1666	GTP binding
TP50_03170	COG0697	spore germination
TP50_03175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TP50_03180	COG2011	ABC-type metal ion transport system permease component
TP50_03225	COG0508	dehydrogenase complex catalyzes the overall conversion of
TP50_03235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TP50_03255	COG0356	it plays a direct role in the translocation of protons across the membrane
TP50_03265	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TP50_03270	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TP50_03275	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TP50_03280	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TP50_03285	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TP50_03290	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TP50_03305	COG3039	Transposase
TP50_03315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TP50_03320	COG4191	Histidine kinase
TP50_03325	COG2204	response regulator
TP50_03335	COG0577	efflux transmembrane transporter activity
TP50_03335	COG1136	(ABC) transporter
TP50_03345	COG1136	(ABC) transporter
TP50_03350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP50_03355	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TP50_03390	COG2132	Multicopper oxidase
TP50_03405	COG0339	signal peptide processing
TP50_03410	COG3039	Transposase
TP50_03425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TP50_03430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TP50_03435	COG0546	phosphoglycolate phosphatase activity
TP50_03445	COG2819	hydrolase of the alpha beta superfamily
TP50_03455	COG1956	GAF domain-containing protein
TP50_03465	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TP50_03495	COG0720	synthase
TP50_03500	COG4771	TonB-dependent receptor
TP50_03515	COG0513	Belongs to the DEAD box helicase family
TP50_03525	COG0625	glutathione transferase activity
TP50_03555	COG0626	cystathionine gamma-synthase activity
TP50_03565	COG0438	transferase activity, transferring glycosyl groups
TP50_03585	COG0438	transferase activity, transferring glycosyl groups
TP50_03590	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TP50_03630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TP50_03640	COG0277	FAD linked oxidase domain protein
TP50_03645	COG0546	phosphoglycolate phosphatase activity
TP50_03645	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TP50_03660	COG2086	electron transfer activity
TP50_03700	COG0662	Cupin 2, conserved barrel domain protein
TP50_03700	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TP50_03705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TP50_03735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TP50_03735	COG3218	ABC-type transport auxiliary lipoprotein component
TP50_03740	COG1127	ABC transporter
TP50_03745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TP50_03765	COG0442	prolyl-tRNA aminoacylation
TP50_03775	COG1183	phosphatidylcholine synthase activity
TP50_03810	COG3039	Transposase
TP50_03820	COG0525	valine-tRNA ligase activity
TP50_03835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TP50_03845	COG0795	lipopolysaccharide-transporting ATPase activity
TP50_03860	COG4974	Belongs to the 'phage' integrase family
TP50_03870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TP50_03875	COG0047	phosphoribosylformylglycinamidine synthase activity
TP50_03875	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TP50_03955	COG2801	Transposase and inactivated derivatives
TP50_03960	COG2963	transposase activity
TP50_04040	COG1063	alcohol dehydrogenase
TP50_04055	COG1132	(ABC) transporter
TP50_04075	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TP50_04080	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_04095	COG1294	oxidase, subunit
TP50_04100	COG1271	oxidase subunit
TP50_04105	COG3039	Transposase
TP50_04110	COG5295	Hep Hag repeat protein
TP50_04115	COG1404	Belongs to the peptidase S8 family
TP50_04120	COG5295	Hep Hag repeat protein
TP50_04125	COG1404	Belongs to the peptidase S8 family
TP50_04130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TP50_04135	COG1459	type II secretion system
TP50_04140	COG2165	general secretion pathway protein
TP50_04145	COG4970	Tfp pilus assembly protein FimT
TP50_04150	COG2165	general secretion pathway protein
TP50_04155	COG4795	General secretion pathway protein
TP50_04160	COG3156	type II secretion system protein K
TP50_04165	COG3166	PFAM Fimbrial assembly family protein
TP50_04180	COG1450	Type ii and iii secretion system protein
TP50_04190	COG2188	Transcriptional regulator
TP50_04270	COG1215	transferase activity, transferring glycosyl groups
TP50_04275	COG1215	transferase activity, transferring glycosyl groups
TP50_04285	COG0457	Tetratricopeptide repeat
TP50_04310	COG0242	peptide deformylase activity
TP50_04315	COG1307	EDD domain protein, DegV family
TP50_04335	COG0402	S-adenosylhomocysteine deaminase activity
TP50_04340	COG3964	amidohydrolase
TP50_04355	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TP50_04360	COG0726	polysaccharide deacetylase
TP50_04375	COG0436	Aminotransferase
TP50_04390	COG3039	Transposase
TP50_04400	COG3039	Transposase
TP50_04410	COG3039	Transposase
TP50_04415	COG3039	Transposase
TP50_04420	COG1162	GTPase activity
TP50_04445	COG2211	Major facilitator Superfamily
TP50_04450	COG1609	Transcriptional regulator
TP50_04455	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_04460	COG2851	Citrate transporter
TP50_04475	COG0642	Histidine kinase
TP50_04480	COG1840	ABC-type Fe3 transport system, periplasmic component
TP50_04485	COG2197	response regulator
TP50_04500	COG0667	Aldo Keto reductase
TP50_04510	COG0583	DNA-binding transcription factor activity
TP50_04535	COG1301	dicarboxylic acid transport
TP50_04540	COG0281	malic enzyme
TP50_04540	COG0280	phosphate acetyltransferase
TP50_04565	COG1560	Kdo2-lipid A biosynthetic process
TP50_04570	COG1519	Transferase
TP50_04575	COG1538	Outer membrane efflux protein
TP50_04580	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TP50_04600	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TP50_04605	COG0066	3-isopropylmalate dehydratase activity
TP50_04610	COG0473	3-isopropylmalate dehydrogenase activity
TP50_04625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TP50_04645	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TP50_04650	COG0405	Gamma-glutamyltransferase
TP50_04655	COG0840	transmembrane signaling receptor activity
TP50_04665	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TP50_04670	COG3710	Transcriptional regulator
TP50_04690	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TP50_04700	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TP50_04710	COG3039	Transposase
TP50_04720	COG0563	adenylate kinase activity
TP50_04725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TP50_04735	COG3781	membrane
TP50_04740	COG0671	phosphoesterase, PA-phosphatase related
TP50_04750	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_04755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TP50_04760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TP50_04790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TP50_04805	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TP50_04815	COG0352	thiamine-phosphate diphosphorylase activity
TP50_04820	COG1773	rubredoxin
TP50_04825	COG2912	Transglutaminase-like superfamily
TP50_04835	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TP50_04845	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TP50_04860	COG3079	Belongs to the UPF0149 family
TP50_04865	COG0006	proline dipeptidase activity
TP50_04870	COG0006	proline dipeptidase activity
TP50_04885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TP50_04890	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TP50_04900	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TP50_04905	COG1561	YicC-like family, N-terminal region
TP50_04915	COG1758	RNA polymerase activity
TP50_04920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TP50_04925	COG0583	DNA-binding transcription factor activity
TP50_04940	COG2271	Major facilitator Superfamily
TP50_04955	COG2721	sulfolactate sulfo-lyase activity
TP50_04965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TP50_04975	COG0254	rRNA binding
TP50_04990	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TP50_05025	COG0714	Associated with various cellular activities
TP50_05045	COG2304	oxidoreductase activity
TP50_05055	COG1301	dicarboxylic acid transport
TP50_05060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TP50_05080	COG4773	Receptor
TP50_05085	COG0739	heme binding
TP50_05090	COG1376	ErfK ybiS ycfS ynhG family protein
TP50_05125	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TP50_05130	COG4149	molybdate abc transporter
TP50_05135	COG0725	ABC transporter, periplasmic molybdate-binding protein
TP50_05140	COG3453	Protein conserved in bacteria
TP50_05140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TP50_05150	COG3047	cAMP biosynthetic process
TP50_05155	COG3047	cAMP biosynthetic process
TP50_05165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TP50_05185	COG0126	phosphoglycerate kinase activity
TP50_05195	COG0469	pyruvate kinase activity
TP50_05200	COG3588	fructose-bisphosphate aldolase
TP50_05205	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TP50_05255	COG0175	sulfate reduction
TP50_05260	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TP50_05265	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TP50_05270	COG0175	sulfate reduction
TP50_05275	COG2895	sulfate adenylyltransferase (ATP) activity
TP50_05275	COG0529	Catalyzes the synthesis of activated sulfate
TP50_05280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP50_05285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP50_05290	COG0308	aminopeptidase N
TP50_05300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TP50_05310	COG4948	Mandelate Racemase Muconate Lactonizing
TP50_05315	COG3250	beta-galactosidase activity
TP50_05325	COG1609	Transcriptional regulator
TP50_05335	COG1970	mechanosensitive ion channel activity
TP50_05360	COG0471	metal ion transport
TP50_05360	COG3273	potassium ion transport
TP50_05365	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TP50_05370	COG2022	thiamine diphosphate biosynthetic process
TP50_05400	COG3039	Transposase
TP50_05405	COG3039	Transposase
TP50_05425	COG3039	Transposase
TP50_05435	COG0189	ligase activity
TP50_05445	COG0745	RESPONSE REGULATOR receiver
TP50_05455	COG2801	Transposase and inactivated derivatives
TP50_05460	COG2963	transposase activity
TP50_05480	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TP50_05485	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TP50_05490	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TP50_05495	COG2205	protein histidine kinase activity
TP50_05500	COG0745	RESPONSE REGULATOR receiver
TP50_05505	COG0277	FAD linked oxidase domain protein
TP50_05510	COG1988	membrane-bound metal-dependent
TP50_05515	COG0792	nuclease activity
TP50_05535	COG2001	Belongs to the MraZ family
TP50_05540	COG0275	rRNA processing
TP50_05545	COG3116	cell division
TP50_05555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TP50_05560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TP50_05565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TP50_05575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TP50_05580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TP50_05585	COG1181	Belongs to the D-alanine--D-alanine ligase family
TP50_05590	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TP50_05605	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TP50_05615	COG0739	heme binding
TP50_05620	COG0653	protein targeting
TP50_05625	COG0494	nUDIX hydrolase
TP50_05635	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TP50_05645	COG3321	synthase
TP50_05645	COG0604	alcohol dehydrogenase
TP50_05645	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_05665	COG0366	Alpha amylase catalytic
TP50_05700	COG2226	methyltransferase
TP50_05705	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TP50_05780	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TP50_05790	COG4106	trans-aconitate 2-methyltransferase activity
TP50_05795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TP50_05805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TP50_05810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TP50_05820	COG0667	Aldo Keto reductase
TP50_05830	COG3039	Transposase
TP50_05835	COG4771	TonB-dependent receptor
TP50_05855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TP50_05860	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TP50_05870	COG2175	clavaminate synthase activity
TP50_05880	COG4181	ATPase activity
TP50_05895	COG0642	Histidine kinase
TP50_05905	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TP50_05925	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TP50_05930	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TP50_05945	COG3829	transcription factor binding
TP50_05955	COG1116	anion transmembrane transporter activity
TP50_05960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TP50_05970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TP50_05975	COG0431	NADPH-dependent FMN reductase
TP50_06025	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TP50_06030	COG2967	ApaG domain
TP50_06035	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TP50_06040	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TP50_06085	COG1196	nuclear chromosome segregation
TP50_06130	COG1652	LysM domain
TP50_06135	COG0242	peptide deformylase activity
TP50_06140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TP50_06145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TP50_06145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TP50_06195	COG1560	Kdo2-lipid A biosynthetic process
TP50_06200	COG1490	D-aminoacyl-tRNA deacylase activity
TP50_06205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TP50_06330	COG0305	Participates in initiation and elongation during chromosome replication
TP50_06350	COG3657	addiction module killer protein
TP50_06370	COG3179	chitinase
TP50_06415	COG1802	Transcriptional regulator
TP50_06415	COG4626	Terminase
TP50_06555	COG0582	viral genome integration into host DNA
TP50_06565	COG3039	Transposase
TP50_06575	COG2204	response regulator
TP50_06610	COG3546	catalase activity
TP50_06615	COG3685	Protein conserved in bacteria
TP50_06630	COG2972	Histidine kinase
TP50_06645	COG0531	amino acid
TP50_06660	COG3590	peptidase
TP50_06670	COG0667	Aldo Keto reductase
TP50_06680	COG0583	DNA-binding transcription factor activity
TP50_06690	COG3384	dioxygenase
TP50_06700	COG1573	uracil-dna glycosylase
TP50_06725	COG4221	oxidoreductase activity
TP50_06735	COG0435	Glutathione S-transferase
TP50_06770	COG0823	Involved in the tonB-independent uptake of proteins
TP50_06770	COG1506	peptidase
TP50_06780	COG3706	GGDEF domain
TP50_06800	COG0697	spore germination
TP50_06805	COG3039	Transposase
TP50_06825	COG1113	amino acid transport
TP50_06835	COG3039	Transposase
TP50_06845	COG0598	Magnesium transport protein CorA
TP50_06855	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
TP50_06915	COG3039	Transposase
TP50_06920	COG0840	transmembrane signaling receptor activity
TP50_06930	COG0659	secondary active sulfate transmembrane transporter activity
TP50_06935	COG3706	GGDEF domain
TP50_06945	COG2943	transferase activity, transferring hexosyl groups
TP50_06955	COG3275	phosphorelay sensor kinase activity
TP50_06965	COG0181	hydroxymethylbilane synthase activity
TP50_06990	COG1505	serine-type exopeptidase activity
TP50_07005	COG2832	Protein of unknown function (DUF454)
TP50_07015	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TP50_07025	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TP50_07030	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TP50_07035	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TP50_07060	COG2226	methyltransferase
TP50_07070	COG0308	aminopeptidase N
TP50_07100	COG2010	Cytochrome c
TP50_07120	COG3284	Transcriptional regulator
TP50_07130	COG1077	Cell shape determining protein MreB Mrl
TP50_07135	COG1792	Involved in formation and maintenance of cell shape
TP50_07150	COG0772	Belongs to the SEDS family
TP50_07160	COG2951	lytic endotransglycosylase activity
TP50_07165	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TP50_07170	COG1686	Belongs to the peptidase S11 family
TP50_07180	COG2921	Belongs to the UPF0250 family
TP50_07185	COG0321	lipoyl(octanoyl) transferase activity
TP50_07190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TP50_07205	COG0583	DNA-binding transcription factor activity
TP50_07215	COG1056	cytidyltransferase-related domain
TP50_07215	COG1051	belongs to the nudix hydrolase family
TP50_07250	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TP50_07255	COG0673	inositol 2-dehydrogenase activity
TP50_07260	COG2823	Periplasmic or secreted lipoprotein
TP50_07265	COG4251	negative regulation of phosphorylation
TP50_07270	COG0784	Response regulator, receiver
TP50_07275	COG4191	Histidine kinase
TP50_07280	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TP50_07335	COG1459	type II secretion system
TP50_07355	COG4795	General secretion pathway protein
TP50_07425	COG1609	Transcriptional regulator
TP50_07430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TP50_07435	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TP50_07450	COG0617	tRNA 3'-terminal CCA addition
TP50_07475	COG1012	belongs to the aldehyde dehydrogenase family
TP50_07480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TP50_07490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TP50_07505	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TP50_07510	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TP50_07530	COG2205	protein histidine kinase activity
TP50_07535	COG0745	RESPONSE REGULATOR receiver
TP50_07560	COG3791	Glutathione-dependent formaldehyde-activating
TP50_07575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TP50_07585	COG0697	spore germination
TP50_07595	COG0488	(ABC) transporter
TP50_07605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TP50_07610	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TP50_07620	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TP50_07620	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TP50_07640	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TP50_07645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TP50_07650	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TP50_07655	COG2801	Transposase and inactivated derivatives
TP50_07660	COG2963	transposase activity
TP50_07665	COG3039	Transposase
TP50_07680	COG0237	dephospho-CoA kinase activity
TP50_07685	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TP50_07690	COG1459	type II secretion system
TP50_07725	COG0045	succinate-CoA ligase (ADP-forming) activity
TP50_07730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TP50_07740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TP50_07740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TP50_07750	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TP50_07755	COG0564	pseudouridine synthase activity
TP50_07770	COG3011	Protein conserved in bacteria
TP50_07775	COG0840	transmembrane signaling receptor activity
TP50_07790	COG3387	PFAM Glycoside hydrolase 15-related
TP50_07795	COG1877	trehalose-phosphatase activity
TP50_07835	COG2827	Endonuclease containing a URI domain
TP50_07840	COG4771	TonB-dependent receptor
TP50_07850	COG0667	Aldo Keto reductase
TP50_07855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TP50_07860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TP50_07865	COG1116	anion transmembrane transporter activity
TP50_07870	COG0542	response to heat
TP50_07880	COG4206	TonB-dependent receptor
TP50_07905	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TP50_07915	COG1492	cobalamin metabolic process
TP50_07925	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TP50_07950	COG2963	transposase activity
TP50_07955	COG2801	Transposase and inactivated derivatives
TP50_07980	COG0019	diaminopimelate decarboxylase activity
TP50_07995	COG4264	IucA IucC family
TP50_08005	COG4772	TonB-dependent receptor
TP50_08015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TP50_08015	COG4651	solute:proton antiporter activity
TP50_08045	COG0488	(ABC) transporter
TP50_08080	COG3039	Transposase
TP50_08085	COG0477	Major facilitator Superfamily
TP50_08100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TP50_08115	COG0217	transcriptional regulatory protein
TP50_08120	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TP50_08125	COG0632	four-way junction helicase activity
TP50_08130	COG3158	transport of potassium into the cell
TP50_08135	COG2255	four-way junction helicase activity
TP50_08140	COG0824	Thioesterase
TP50_08150	COG0848	biopolymer transport protein
TP50_08160	COG0823	Involved in the tonB-independent uptake of proteins
TP50_08165	COG2885	chlorophyll binding
TP50_08175	COG0602	queuosine metabolic process
TP50_08190	COG3920	Histidine kinase
TP50_08210	COG0840	transmembrane signaling receptor activity
TP50_08255	COG0514	ATP-dependent DNA helicase (RecQ)
TP50_08260	COG0783	Belongs to the Dps family
TP50_08265	COG1643	Atp-dependent helicase
TP50_08275	COG0837	glucose binding
TP50_08290	COG0535	radical SAM domain protein
TP50_08295	COG0535	radical SAM domain protein
TP50_08300	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
TP50_08305	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TP50_08310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TP50_08320	COG1215	transferase activity, transferring glycosyl groups
TP50_08325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TP50_08335	COG1199	ATP-dependent helicase activity
TP50_08345	COG1397	ADP-ribosylglycohydrolase
TP50_08355	COG0189	ligase activity
TP50_08370	COG0835	chemotaxis
TP50_08375	COG0840	transmembrane signaling receptor activity
TP50_08405	COG1446	asparaginase
TP50_08410	COG3142	Participates in the control of copper homeostasis
TP50_08460	COG3537	Alpha-1,2-mannosidase
TP50_08470	COG1486	melibiose metabolic process
TP50_08480	COG0531	amino acid
TP50_08495	COG1472	Belongs to the glycosyl hydrolase 3 family
TP50_08505	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TP50_08510	COG3858	chitin binding
TP50_08510	COG1388	LysM domain
TP50_08525	COG0837	glucose binding
TP50_08530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TP50_08540	COG0494	nUDIX hydrolase
TP50_08545	COG1218	3'(2'),5'-bisphosphate nucleotidase
TP50_08550	COG3956	TIGRFAM MazG family protein
TP50_08555	COG1742	UPF0060 membrane protein
TP50_08565	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TP50_08570	COG0509	glycine decarboxylation via glycine cleavage system
TP50_08600	COG1960	acyl-CoA dehydrogenase activity
TP50_08605	COG2267	carboxylic ester hydrolase activity
TP50_08610	COG1309	transcriptional regulator
TP50_08620	COG4771	TonB-dependent receptor
TP50_08630	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TP50_08635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TP50_08640	COG0463	Glycosyl transferase, family 2
TP50_08645	COG0517	IMP dehydrogenase activity
TP50_08645	COG0516	GMP reductase activity
TP50_08650	COG2982	Protein involved in outer membrane biogenesis
TP50_08655	COG1272	protein, Hemolysin III
TP50_08660	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TP50_08665	COG0739	heme binding
TP50_08670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TP50_08675	COG0626	cystathionine gamma-synthase activity
TP50_08680	COG0460	homoserine dehydrogenase
TP50_08680	COG0527	aspartate kinase activity
TP50_08695	COG1760	l-serine dehydratase
TP50_08715	COG2353	YceI-like domain
TP50_08720	COG2198	Histidine kinase
TP50_08720	COG0784	Response regulator, receiver
TP50_08720	COG2205	protein histidine kinase activity
TP50_08740	COG3039	Transposase
TP50_08755	COG0477	Major facilitator Superfamily
TP50_08760	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TP50_08770	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TP50_08775	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TP50_08780	COG0259	pyridoxamine-phosphate oxidase activity
TP50_08790	COG1842	Phage shock protein A
TP50_08815	COG0754	glutathionylspermidine amidase activity
TP50_08825	COG2814	Major facilitator Superfamily
TP50_08900	COG0531	amino acid
TP50_08905	COG2197	response regulator
TP50_08925	COG1113	amino acid transport
TP50_08935	COG1271	oxidase subunit
TP50_08940	COG1294	oxidase, subunit
TP50_08950	COG2239	Acts as a magnesium transporter
TP50_08955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TP50_08960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TP50_08970	COG1660	Displays ATPase and GTPase activities
TP50_08975	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TP50_08980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TP50_08995	COG1137	ATPase activity
TP50_09000	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
TP50_09010	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TP50_09020	COG0271	Belongs to the BolA IbaG family
TP50_09025	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TP50_09045	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TP50_09055	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TP50_09065	COG0628	permease
TP50_09085	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TP50_09090	COG3178	'Phosphotransferase
TP50_09105	COG1555	photosystem II stabilization
TP50_09135	COG3039	Transposase
TP50_09140	COG2963	transposase activity
TP50_09145	COG2963	transposase activity
TP50_09150	COG2801	Transposase and inactivated derivatives
TP50_09160	COG1024	Enoyl-CoA hydratase
TP50_09160	COG1250	3-hydroxyacyl-CoA dehydrogenase
TP50_09175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TP50_09180	COG0481	GTPase activity
TP50_09195	COG0571	ribonuclease III activity
TP50_09200	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TP50_09205	COG1381	Involved in DNA repair and RecF pathway recombination
TP50_09215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TP50_09220	COG3039	Transposase
TP50_09230	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TP50_09235	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
TP50_09240	COG3046	protein related to deoxyribodipyrimidine photolyase
TP50_09245	COG1472	Belongs to the glycosyl hydrolase 3 family
TP50_09255	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TP50_09260	COG1278	Cold shock
TP50_09265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TP50_09275	COG1201	RNA secondary structure unwinding
TP50_09280	COG1793	dna ligase
TP50_09290	COG1793	dna ligase
TP50_09290	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TP50_09305	COG0745	RESPONSE REGULATOR receiver
TP50_09305	COG3706	GGDEF domain
TP50_09320	COG0183	Belongs to the thiolase family
TP50_09335	COG1451	nucleotide metabolic process
TP50_09340	COG5487	UPF0391 membrane protein
TP50_09350	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TP50_09375	COG1047	Peptidyl-prolyl cis-trans
TP50_09385	COG2824	Alkylphosphonate utilization operon protein PhnA
TP50_09390	COG1902	pentaerythritol trinitrate reductase activity
TP50_09395	COG2814	Major facilitator Superfamily
TP50_09430	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TP50_09430	COG0392	lysyltransferase activity
TP50_09440	COG0251	oxidation-reduction process
TP50_09445	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TP50_09460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TP50_09485	COG1595	DNA-templated transcription, initiation
TP50_09530	COG5449	Phage conserved hypothetical protein BR0599
TP50_09595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TP50_09595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TP50_09610	COG1131	(ABC) transporter
TP50_09615	COG0346	lactoylglutathione lyase activity
TP50_09620	COG0833	amino acid
TP50_09625	COG2040	homocysteine
TP50_09635	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
TP50_09665	COG1695	Transcriptional regulator
TP50_09705	COG4584	PFAM Integrase catalytic
TP50_09720	COG0825	malonyl-CoA metabolic process
TP50_09735	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TP50_09740	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TP50_09745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TP50_09750	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TP50_09765	COG0750	zinc metalloprotease
TP50_09770	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TP50_09775	COG0575	Belongs to the CDS family
TP50_09780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TP50_09785	COG0233	cytoplasmic translational termination
TP50_09790	COG0528	UMP kinase activity
TP50_09795	COG3706	GGDEF domain
TP50_09795	COG0745	RESPONSE REGULATOR receiver
TP50_09800	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TP50_09805	COG0052	Belongs to the universal ribosomal protein uS2 family
TP50_09840	COG3039	Transposase
TP50_09845	COG0024	Methionine aminopeptidase
TP50_09850	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TP50_09860	COG1393	Belongs to the ArsC family
TP50_09865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TP50_09870	COG0367	asparagine synthase
TP50_09880	COG4774	siderophore transport
TP50_09895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TP50_09920	COG1566	PFAM secretion protein HlyD family protein
TP50_09925	COG2814	Major facilitator Superfamily
TP50_09945	COG3104	oligopeptide transport
TP50_09975	COG0339	signal peptide processing
TP50_10005	COG3039	Transposase
TP50_10060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TP50_10065	COG0084	hydrolase, TatD family'
TP50_10080	COG1960	acyl-CoA dehydrogenase activity
TP50_10100	COG0367	asparagine synthase
TP50_10110	COG0305	Participates in initiation and elongation during chromosome replication
TP50_10115	COG0415	Belongs to the DNA photolyase family
TP50_10125	COG0583	DNA-binding transcription factor activity
TP50_10160	COG3706	GGDEF domain
TP50_10170	COG3706	GGDEF domain
TP50_10200	COG3039	Transposase
TP50_10205	COG2963	transposase activity
TP50_10210	COG2801	Transposase and inactivated derivatives
TP50_10225	COG0753	catalase activity
TP50_10230	COG0656	L-ascorbic acid biosynthetic process
TP50_10240	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TP50_10240	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TP50_10245	COG2814	Major facilitator Superfamily
TP50_10260	COG2194	sulfuric ester hydrolase activity
TP50_10275	COG0745	RESPONSE REGULATOR receiver
TP50_10280	COG0642	Histidine kinase
TP50_10290	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TP50_10295	COG2894	cell division
TP50_10300	COG0850	regulation of cytokinetic process
TP50_10310	COG4585	Histidine kinase
TP50_10315	COG2197	response regulator
TP50_10355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TP50_10365	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TP50_10385	COG1946	Acyl-CoA thioesterase
TP50_10400	COG0824	Thioesterase
TP50_10405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TP50_10410	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TP50_10415	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TP50_10420	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TP50_10425	COG0268	Binds directly to 16S ribosomal RNA
TP50_10435	COG0196	riboflavin kinase activity
TP50_10440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TP50_10445	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TP50_10450	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TP50_10495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TP50_10500	COG1845	cytochrome c oxidase, subunit III
TP50_10505	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
TP50_10520	COG3152	Membrane
TP50_10530	COG3039	Transposase
TP50_10535	COG2207	Transcriptional regulator
TP50_10550	COG1366	Belongs to the anti-sigma-factor antagonist family
TP50_10555	COG1366	Belongs to the anti-sigma-factor antagonist family
TP50_10560	COG2172	sigma factor antagonist activity
TP50_10595	COG4771	TonB-dependent receptor
TP50_10605	COG5507	3-demethylubiquinone-9 3-methyltransferase
TP50_10610	COG2205	protein histidine kinase activity
TP50_10620	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TP50_10625	COG3850	Histidine kinase
TP50_10625	COG4999	Histidine kinase
TP50_10625	COG2205	protein histidine kinase activity
TP50_10625	COG3437	response regulator, receiver
TP50_10630	COG4191	Histidine kinase
TP50_10630	COG0784	Response regulator, receiver
TP50_10660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TP50_10665	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TP50_10680	COG0228	four-way junction DNA binding
TP50_10685	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TP50_10690	COG0336	Belongs to the RNA methyltransferase TrmD family
TP50_10695	COG0335	large ribosomal subunit rRNA binding
TP50_10700	COG0534	Mate efflux family protein
TP50_10725	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TP50_10735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TP50_10745	COG2963	transposase activity
TP50_10750	COG2801	Transposase and inactivated derivatives
TP50_10770	COG3250	beta-galactosidase activity
TP50_10775	COG3867	Arabinogalactan endo-beta-1,4-galactanase
TP50_10795	COG1960	acyl-CoA dehydrogenase activity
TP50_10800	COG1024	Enoyl-CoA hydratase
TP50_10830	COG3039	Transposase
TP50_10840	COG1477	protein flavinylation
TP50_10865	COG3128	pkhd-type hydroxylase
TP50_10870	COG4774	siderophore transport
TP50_10885	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TP50_10890	COG0719	Fe-S assembly protein
TP50_10895	COG0396	ATPase activity
TP50_10900	COG0719	Fe-S assembly protein
TP50_10905	COG1959	2 iron, 2 sulfur cluster binding
TP50_10920	COG3039	Transposase
TP50_10945	COG0739	heme binding
TP50_10960	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TP50_10985	COG0519	Catalyzes the synthesis of GMP from XMP
TP50_10995	COG1678	Uncharacterized ACR, COG1678
TP50_11000	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TP50_11005	COG0540	Belongs to the ATCase OTCase family
TP50_11010	COG1764	response to oxidative stress
TP50_11020	COG0384	phenazine biosynthesis protein PhzF
TP50_11025	COG0384	phenazine biosynthesis protein PhzF
TP50_11030	COG0527	aspartate kinase activity
TP50_11045	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TP50_11055	COG0142	geranyltranstransferase activity
TP50_11060	COG0629	single-stranded DNA binding
TP50_11065	COG2203	Gaf domain
TP50_11065	COG3706	GGDEF domain
TP50_11065	COG4251	negative regulation of phosphorylation
TP50_11065	COG5001	Diguanylate cyclase
TP50_11070	COG0604	alcohol dehydrogenase
TP50_11070	COG3321	synthase
TP50_11070	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_11075	COG2080	2 iron, 2 sulfur cluster binding
TP50_11080	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TP50_11085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TP50_11090	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TP50_11135	COG3039	Transposase
TP50_11140	COG2879	small protein
TP50_11145	COG1966	Carbon starvation protein
TP50_11150	COG1741	Belongs to the pirin family
TP50_11165	COG1741	Belongs to the pirin family
TP50_11175	COG3039	Transposase
TP50_11180	COG1515	deoxyribonuclease V activity
TP50_11185	COG0588	phosphoglycerate mutase activity
TP50_11195	COG3590	peptidase
TP50_11210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP50_11215	COG2201	protein-glutamate methylesterase activity
TP50_11220	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TP50_11225	COG2202	Pas domain
TP50_11225	COG2199	diguanylate cyclase activity
TP50_11225	COG2200	EAL domain
TP50_11230	COG0835	chemotaxis
TP50_11235	COG0840	transmembrane signaling receptor activity
TP50_11240	COG2198	Histidine kinase
TP50_11240	COG0643	Histidine kinase
TP50_11295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TP50_11305	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TP50_11310	COG3039	Transposase
TP50_11315	COG0745	RESPONSE REGULATOR receiver
TP50_11320	COG2205	protein histidine kinase activity
TP50_11335	COG4452	Inner membrane protein CreD
TP50_11360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TP50_11365	COG0735	belongs to the Fur family
TP50_11380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP50_11385	COG1538	Outer membrane efflux protein
TP50_11390	COG1309	transcriptional regulator
TP50_11400	COG2207	Transcriptional regulator
TP50_11410	COG0583	DNA-binding transcription factor activity
TP50_11415	COG2814	Major facilitator Superfamily
TP50_11420	COG0667	Aldo Keto reductase
TP50_11460	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TP50_11475	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TP50_11485	COG0497	DNA recombination
TP50_11490	COG1420	regulation of RNA biosynthetic process
TP50_11495	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TP50_11500	COG0443	Heat shock 70 kDa protein
TP50_11505	COG0484	heat shock protein binding
TP50_11510	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
TP50_11540	COG0583	DNA-binding transcription factor activity
TP50_11545	COG1132	(ABC) transporter
TP50_11580	COG2850	peptidyl-arginine hydroxylation
TP50_11605	COG1253	flavin adenine dinucleotide binding
TP50_11635	COG1131	(ABC) transporter
TP50_11640	COG1725	Transcriptional regulator
TP50_11645	COG0386	Belongs to the glutathione peroxidase family
TP50_11660	COG2900	Belongs to the SlyX family
TP50_11700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TP50_11710	COG0646	methionine synthase
TP50_11710	COG1410	methionine synthase
TP50_11715	COG1410	methionine synthase
TP50_11715	COG0646	methionine synthase
TP50_11725	COG1960	acyl-CoA dehydrogenase activity
TP50_11730	COG1960	acyl-CoA dehydrogenase activity
TP50_11745	COG0557	exoribonuclease II activity
TP50_11755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TP50_11760	COG3706	GGDEF domain
TP50_11765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TP50_11775	COG0704	Plays a role in the regulation of phosphate uptake
TP50_11780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TP50_11785	COG0581	inorganic phosphate transmembrane transporter activity
TP50_11790	COG0573	inorganic phosphate transmembrane transporter activity
TP50_11795	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TP50_11820	COG0659	secondary active sulfate transmembrane transporter activity
TP50_11825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TP50_11835	COG1024	Enoyl-CoA hydratase
TP50_11845	COG0494	nUDIX hydrolase
TP50_11885	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TP50_11885	COG0116	Belongs to the methyltransferase superfamily
TP50_11890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TP50_11910	COG2925	Exonuclease
TP50_11915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TP50_11920	COG3844	kynureninase activity
TP50_11930	COG0662	Cupin 2, conserved barrel domain protein
TP50_11935	COG0288	reversible hydration of carbon dioxide
TP50_12020	COG0017	Asparaginyl-tRNA synthetase
TP50_12025	COG0316	Belongs to the HesB IscA family
TP50_12030	COG0360	Binds together with S18 to 16S ribosomal RNA
TP50_12035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TP50_12040	COG0359	binds to the 23S rRNA
TP50_12055	COG3115	cell septum assembly
TP50_12065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TP50_12070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TP50_12075	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TP50_12085	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TP50_12095	COG4993	Dehydrogenase
TP50_12105	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TP50_12115	COG2986	histidine ammonia-lyase
TP50_12120	COG1228	amidohydrolase
TP50_12160	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
TP50_12165	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TP50_12170	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TP50_12175	COG1605	Chorismate mutase
TP50_12175	COG0077	Prephenate dehydratase
TP50_12180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TP50_12195	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TP50_12220	COG0583	DNA-binding transcription factor activity
TP50_12270	COG1335	isochorismatase
TP50_12285	COG2814	Major facilitator Superfamily
TP50_12300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TP50_12300	COG1648	precorrin-2 dehydrogenase activity
TP50_12315	COG3685	Protein conserved in bacteria
TP50_12335	COG5001	Diguanylate cyclase
TP50_12340	COG2963	transposase activity
TP50_12355	COG2801	Transposase and inactivated derivatives
TP50_12370	COG4566	intracellular signal transduction
TP50_12405	COG3275	phosphorelay sensor kinase activity
TP50_12410	COG3279	Response regulator of the LytR AlgR family
TP50_12450	COG1238	metal cluster binding
TP50_12470	COG3920	Histidine kinase
TP50_12485	COG3220	belongs to the UPF0276 family
TP50_12500	COG3039	Transposase
TP50_12520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TP50_12545	COG4644	lycopene metabolic process
TP50_12550	COG2951	lytic endotransglycosylase activity
TP50_12555	COG3039	Transposase
TP50_12660	COG3039	Transposase
TP50_12690	COG2963	transposase activity
TP50_12695	COG2801	Transposase and inactivated derivatives
TP50_12725	COG2801	Transposase and inactivated derivatives
TP50_12735	COG0519	Catalyzes the synthesis of GMP from XMP
TP50_12735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TP50_12745	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TP50_12765	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TP50_12765	COG0475	glutathione-regulated potassium exporter activity
TP50_12770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TP50_12780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TP50_12785	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
TP50_12795	COG0776	regulation of translation
TP50_12800	COG0539	negative regulation of cytoplasmic translation
TP50_12805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TP50_12810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TP50_12820	COG2957	Belongs to the agmatine deiminase family
TP50_12825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TP50_12860	COG0395	ABC-type sugar transport system, permease component
TP50_12865	COG1175	transmembrane transport
TP50_12895	COG2350	Protein conserved in bacteria
TP50_12900	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TP50_12905	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TP50_12910	COG1187	pseudouridine synthase activity
TP50_12940	COG2801	Transposase and inactivated derivatives
TP50_12945	COG2963	transposase activity
TP50_12970	COG3039	Transposase
TP50_13000	COG1012	belongs to the aldehyde dehydrogenase family
TP50_13015	COG0167	dihydroorotate dehydrogenase activity
TP50_13020	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TP50_13025	COG0697	spore germination
TP50_13030	COG1794	racemase activity, acting on amino acids and derivatives
TP50_13040	COG0671	phosphoesterase, PA-phosphatase related
TP50_13045	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TP50_13055	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TP50_13060	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TP50_13065	COG5001	Diguanylate cyclase
TP50_13065	COG4251	negative regulation of phosphorylation
TP50_13065	COG3706	GGDEF domain
TP50_13065	COG2203	Gaf domain
TP50_13075	COG1472	Belongs to the glycosyl hydrolase 3 family
TP50_13100	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TP50_13105	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TP50_13110	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TP50_13130	COG1469	GTP cyclohydrolase I activity
TP50_13135	COG0860	N-Acetylmuramoyl-L-alanine amidase
TP50_13140	COG3039	Transposase
TP50_13170	COG0477	Major facilitator Superfamily
TP50_13175	COG2115	Belongs to the xylose isomerase family
TP50_13180	COG1070	Carbohydrate kinase
TP50_13190	COG1501	Belongs to the glycosyl hydrolase 31 family
TP50_13230	COG0800	Aldolase
TP50_13235	COG4948	Mandelate Racemase Muconate Lactonizing
TP50_13245	COG3734	2-keto-3-deoxy-galactonokinase
TP50_13250	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TP50_13260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TP50_13275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TP50_13280	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TP50_13295	COG0351	phosphomethylpyrimidine kinase
TP50_13345	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TP50_13350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TP50_13355	COG2137	regulation of response to DNA damage stimulus
TP50_13360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TP50_13365	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TP50_13375	COG1546	Belongs to the CinA family
TP50_13380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TP50_13385	COG1923	regulation of RNA biosynthetic process
TP50_13390	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TP50_13395	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TP50_13400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TP50_13405	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TP50_13410	COG1534	Rna-binding protein
TP50_13425	COG1238	metal cluster binding
TP50_13430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TP50_13435	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TP50_13440	COG2840	Smr protein MutS2
TP50_13445	COG0585	pseudouridine synthase activity
TP50_13450	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TP50_13455	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TP50_13460	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TP50_13465	COG0148	phosphopyruvate hydratase activity
TP50_13480	COG0504	CTP synthase activity
TP50_13485	COG3039	Transposase
TP50_13505	COG2801	Transposase and inactivated derivatives
TP50_13510	COG2963	transposase activity
TP50_13525	COG0306	phosphate transporter
TP50_13535	COG1253	flavin adenine dinucleotide binding
TP50_13550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TP50_13555	COG0477	Major facilitator Superfamily
TP50_13565	COG1136	(ABC) transporter
TP50_13590	COG2264	protein methyltransferase activity
TP50_13620	COG2244	polysaccharide biosynthetic process
TP50_13670	COG1595	DNA-templated transcription, initiation
TP50_13685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TP50_13695	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TP50_13705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TP50_13720	COG0784	Response regulator, receiver
TP50_13720	COG4191	Histidine kinase
TP50_13725	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TP50_13730	COG0784	Response regulator, receiver
TP50_13730	COG2205	protein histidine kinase activity
TP50_13730	COG5002	protein histidine kinase activity
TP50_13765	COG2801	Transposase and inactivated derivatives
TP50_13770	COG2963	transposase activity
TP50_13820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TP50_13825	COG3002	Belongs to the UPF0753 family
TP50_13885	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_13895	COG2801	Transposase and inactivated derivatives
TP50_13900	COG2963	transposase activity
TP50_13920	COG0316	Belongs to the HesB IscA family
TP50_13920	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TP50_13925	COG2154	pterin-4-alpha-carbinolamine dehydratase
TP50_13935	COG0428	transporter
TP50_13940	COG3064	Membrane
TP50_13950	COG1530	ribonuclease E activity
TP50_13990	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TP50_14015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TP50_14020	COG0322	excinuclease ABC activity
TP50_14030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TP50_14035	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TP50_14040	COG1663	tetraacyldisaccharide 4'-kinase activity
TP50_14045	COG1132	(ABC) transporter
TP50_14050	COG0848	biopolymer transport protein
TP50_14055	COG0811	peptide transport
TP50_14070	COG1136	(ABC) transporter
TP50_14075	COG4591	ABC-type transport system involved in lipoprotein release permease component
TP50_14085	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
TP50_14090	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TP50_14105	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TP50_14115	COG0354	folic acid binding
TP50_14125	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TP50_14130	COG0837	glucose binding
TP50_14135	COG0363	glucosamine-6-phosphate deaminase activity
TP50_14140	COG0129	dihydroxy-acid dehydratase activity
TP50_14145	COG0800	Aldolase
TP50_14210	COG0784	Response regulator, receiver
TP50_14210	COG2205	protein histidine kinase activity
TP50_14215	COG2183	response to ionizing radiation
TP50_14225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP50_14225	COG0723	plastoquinol--plastocyanin reductase activity
TP50_14240	COG3243	poly(R)-hydroxyalkanoic acid synthase
TP50_14250	COG1183	phosphatidylcholine synthase activity
TP50_14255	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_14270	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TP50_14280	COG0668	transmembrane transport
TP50_14290	COG0590	tRNA wobble adenosine to inosine editing
TP50_14295	COG1321	iron dependent repressor
TP50_14300	COG1914	H( )-stimulated, divalent metal cation uptake system
TP50_14320	COG2072	flavoprotein involved in K transport
TP50_14340	COG0746	molybdenum cofactor guanylyltransferase activity
TP50_14345	COG0303	'Molybdopterin
TP50_14355	COG0708	Exodeoxyribonuclease III
TP50_14410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TP50_14415	COG0303	'Molybdopterin
TP50_14420	COG1160	GTP binding
TP50_14425	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TP50_14435	COG1426	Protein conserved in bacteria
TP50_14445	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TP50_14450	COG0105	UTP biosynthetic process
TP50_14460	COG1250	3-hydroxyacyl-CoA dehydrogenase
TP50_14460	COG1024	Enoyl-CoA hydratase
TP50_14465	COG0183	Belongs to the thiolase family
TP50_14470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TP50_14475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TP50_14485	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TP50_14495	COG1674	ftsk spoiiie
TP50_14500	COG0492	ferredoxin-NADP+ reductase activity
TP50_14510	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TP50_14515	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TP50_14520	COG0542	response to heat
TP50_14525	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TP50_14535	COG0482	sulfurtransferase activity
TP50_14540	COG2915	High frequency lysogenization protein hflD homolog
TP50_14580	COG5002	protein histidine kinase activity
TP50_14600	COG0835	chemotaxis
TP50_14600	COG0784	Response regulator, receiver
TP50_14610	COG1558	bacterial-type flagellum-dependent cell motility
TP50_14615	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TP50_14620	COG1749	Flagellar hook protein flgE
TP50_14625	COG4787	bacterial-type flagellum-dependent cell motility
TP50_14630	COG4786	Flagellar basal body rod
TP50_14635	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TP50_14640	COG1706	bacterial-type flagellum-dependent cell motility
TP50_14645	COG1705	Flagellar rod assembly protein muramidase FlgJ
TP50_14645	COG3951	Flagellar rod assembly protein muramidase FlgJ
TP50_14655	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TP50_14665	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TP50_14695	COG2201	protein-glutamate methylesterase activity
TP50_14700	COG2204	response regulator
TP50_14715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TP50_14720	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_14725	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_14735	COG4638	Rieske (2fe-2S)
TP50_14760	COG2963	transposase activity
TP50_14765	COG2801	Transposase and inactivated derivatives
TP50_14770	COG1677	Flagellar hook-basal body complex protein FliE
TP50_14820	COG3190	flagellar
TP50_14840	COG1987	bacterial-type flagellum assembly
TP50_14845	COG1684	flagellar biosynthetic protein fliR
TP50_14870	COG3300	MHYT domain
TP50_14870	COG5001	Diguanylate cyclase
TP50_14895	COG0455	bacterial-type flagellum organization
TP50_14915	COG0643	Histidine kinase
TP50_14915	COG2198	Histidine kinase
TP50_14935	COG3039	Transposase
TP50_14945	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TP50_14950	COG1360	Flagellar Motor Protein
TP50_14955	COG1192	Involved in chromosome partitioning
TP50_14960	COG0835	chemotaxis
TP50_14970	COG0745	RESPONSE REGULATOR receiver
TP50_14980	COG0840	transmembrane signaling receptor activity
TP50_14995	COG0840	transmembrane signaling receptor activity
TP50_15000	COG0840	transmembrane signaling receptor activity
TP50_15010	COG0840	transmembrane signaling receptor activity
TP50_15015	COG0840	transmembrane signaling receptor activity
TP50_15020	COG3039	Transposase
TP50_15025	COG0840	transmembrane signaling receptor activity
TP50_15030	COG2963	transposase activity
TP50_15035	COG2801	Transposase and inactivated derivatives
TP50_15045	COG0840	transmembrane signaling receptor activity
TP50_15055	COG0840	transmembrane signaling receptor activity
TP50_15060	COG0840	transmembrane signaling receptor activity
TP50_15065	COG0840	transmembrane signaling receptor activity
TP50_15070	COG0840	transmembrane signaling receptor activity
TP50_15075	COG0840	transmembrane signaling receptor activity
TP50_15085	COG0835	chemotaxis
TP50_15095	COG0840	transmembrane signaling receptor activity
TP50_15105	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TP50_15110	COG2201	protein-glutamate methylesterase activity
TP50_15125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TP50_15155	COG0318	PFAM AMP-dependent synthetase and ligase
TP50_15160	COG1024	Enoyl-CoA hydratase
TP50_15165	COG2198	Histidine kinase
TP50_15165	COG0784	Response regulator, receiver
TP50_15165	COG2205	protein histidine kinase activity
TP50_15180	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TP50_15185	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TP50_15200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TP50_15210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TP50_15215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TP50_15225	COG0505	Belongs to the CarA family
TP50_15230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TP50_15235	COG2258	MOSC domain
TP50_15240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TP50_15285	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TP50_15305	COG0277	FAD linked oxidase domain protein
TP50_15310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TP50_15320	COG0531	amino acid
TP50_15325	COG0531	amino acid
TP50_15330	COG0235	Class ii aldolase
TP50_15335	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TP50_15340	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
TP50_15365	COG0140	phosphoribosyl-ATP diphosphatase activity
TP50_15365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TP50_15370	COG0107	imidazoleglycerol-phosphate synthase activity
TP50_15375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TP50_15380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TP50_15385	COG0131	Imidazoleglycerol-phosphate dehydratase
TP50_15385	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TP50_15390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TP50_15395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TP50_15400	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TP50_15410	COG0124	histidyl-tRNA synthetase
TP50_15415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TP50_15425	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TP50_15460	COG3039	Transposase
TP50_15530	COG3039	Transposase
TP50_15545	COG2801	Transposase and inactivated derivatives
TP50_15550	COG2963	transposase activity
TP50_15570	COG2205	protein histidine kinase activity
TP50_15570	COG0784	Response regulator, receiver
TP50_15580	COG3039	Transposase
TP50_15605	COG0436	Aminotransferase
TP50_15610	COG4133	protoheme IX ABC transporter activity
TP50_15630	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TP50_15635	COG1138	Cytochrome C-type biogenesis protein
TP50_15655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TP50_15660	COG1278	Cold shock
TP50_15665	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TP50_15670	COG4988	ABC transporter
TP50_15680	COG1294	oxidase, subunit
TP50_15715	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TP50_15720	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TP50_15730	COG0165	Argininosuccinate lyase
TP50_15735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TP50_15745	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TP50_15760	COG0137	argininosuccinate synthase activity
TP50_15765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TP50_15775	COG0215	cysteine-tRNA ligase activity
TP50_15780	COG2166	iron-sulfur cluster assembly
TP50_15790	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TP50_15800	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TP50_15805	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TP50_15825	COG4302	ethanolamine ammonia-lyase activity
TP50_15845	COG2801	Transposase and inactivated derivatives
TP50_15850	COG2963	transposase activity
TP50_15860	COG3039	Transposase
TP50_15905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TP50_15910	COG0402	S-adenosylhomocysteine deaminase activity
TP50_15920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TP50_15925	COG1509	lysine 2,3-aminomutase activity
TP50_15930	COG5001	Diguanylate cyclase
TP50_15930	COG3300	MHYT domain
TP50_15945	COG0483	inositol monophosphate 1-phosphatase activity
TP50_15970	COG0513	Belongs to the DEAD box helicase family
TP50_15975	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TP50_15980	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TP50_15990	COG0625	glutathione transferase activity
TP50_16000	COG4681	YaeQ
TP50_16005	COG2081	HI0933 family
TP50_16015	COG0501	Belongs to the peptidase M48B family
TP50_16020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TP50_16025	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_16045	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TP50_16050	COG0860	N-Acetylmuramoyl-L-alanine amidase
TP50_16055	COG0802	atpase or kinase
TP50_16060	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TP50_16060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TP50_16065	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TP50_16070	COG1570	exodeoxyribonuclease VII activity
TP50_16080	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TP50_16120	COG0835	chemotaxis
TP50_16125	COG0840	transmembrane signaling receptor activity
TP50_16130	COG2094	Belongs to the DNA glycosylase MPG family
TP50_16135	COG1201	RNA secondary structure unwinding
TP50_16150	COG2969	positive regulation of protein catabolic process
TP50_16155	COG0625	glutathione transferase activity
TP50_16165	COG2857	Cytochrome c1
TP50_16170	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TP50_16175	COG0723	plastoquinol--plastocyanin reductase activity
TP50_16180	COG0741	lytic transglycosylase activity
TP50_16195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TP50_16200	COG1702	phosphate starvation-inducible protein PhoH
TP50_16210	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TP50_16220	COG4535	Mg2 and Co2 transporter CorC
TP50_16235	COG1012	belongs to the aldehyde dehydrogenase family
TP50_16245	COG1177	transmembrane transport
TP50_16250	COG1176	ABC-type spermidine putrescine transport system, permease component I
TP50_16255	COG3842	ATPase activity
TP50_16275	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TP50_16290	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TP50_16295	COG0174	glutamine synthetase
TP50_16300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP50_16305	COG3706	GGDEF domain
TP50_16305	COG0745	RESPONSE REGULATOR receiver
TP50_16310	COG2703	oxygen carrier activity
TP50_16315	COG0477	Major facilitator Superfamily
TP50_16325	COG0243	molybdopterin cofactor binding
TP50_16330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TP50_16350	COG2733	membrane
TP50_16355	COG0784	Response regulator, receiver
TP50_16355	COG5002	protein histidine kinase activity
TP50_16355	COG2205	protein histidine kinase activity
TP50_16370	COG0477	Major facilitator Superfamily
TP50_16405	COG2902	Dehydrogenase
TP50_16415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP50_16420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP50_16425	COG1609	Transcriptional regulator
TP50_16430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TP50_16430	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TP50_16435	COG1105	Belongs to the carbohydrate kinase PfkB family
TP50_16440	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TP50_16440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TP50_16460	COG0823	Involved in the tonB-independent uptake of proteins
TP50_16460	COG1506	peptidase
TP50_16475	COG1297	OPT oligopeptide transporter protein
TP50_16490	COG0587	DNA-directed DNA polymerase activity
TP50_16510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TP50_16545	COG2080	2 iron, 2 sulfur cluster binding
TP50_16550	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TP50_16555	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TP50_16590	COG0492	ferredoxin-NADP+ reductase activity
TP50_16605	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_16610	COG3537	Alpha-1,2-mannosidase
TP50_16615	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_16620	COG3387	PFAM Glycoside hydrolase 15-related
TP50_16630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TP50_16635	COG0406	alpha-ribazole phosphatase activity
TP50_16635	COG0328	RNA-DNA hybrid ribonuclease activity
TP50_16675	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TP50_16700	COG1309	transcriptional regulator
TP50_16705	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_16715	COG0308	aminopeptidase N
TP50_16720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TP50_16725	COG0330	HflC and HflK could
TP50_16730	COG0330	HflC and HflK could
TP50_16750	COG0678	peroxiredoxin activity
TP50_16760	COG4953	penicillin-binding protein 1C
TP50_16775	COG2373	Large extracellular alpha-helical protein
TP50_16790	COG2828	Protein conserved in bacteria
TP50_16820	COG3829	transcription factor binding
TP50_16845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TP50_16850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TP50_16860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TP50_16865	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_16870	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TP50_16880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TP50_16890	COG1399	metal-binding, possibly nucleic acid-binding protein
TP50_16895	COG0424	maF-like protein
TP50_16920	COG0714	Associated with various cellular activities
TP50_16940	COG0537	adenosine 5'-monophosphoramidase activity
TP50_16945	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TP50_16950	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TP50_16965	COG0314	molybdopterin synthase activity
TP50_16970	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TP50_16975	COG0315	cyclic pyranopterin monophosphate synthase activity
TP50_16985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TP50_16990	COG1234	tRNA 3'-trailer cleavage
TP50_16995	COG3642	lipopolysaccharide core region biosynthetic process
TP50_17000	COG0859	PFAM glycosyl transferase family 9
TP50_17015	COG0631	protein serine/threonine phosphatase activity
TP50_17020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TP50_17025	COG0328	RNA-DNA hybrid ribonuclease activity
TP50_17035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TP50_17045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TP50_17075	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TP50_17080	COG0740	serine-type endopeptidase activity
TP50_17085	COG0544	peptidyl-prolyl cis-trans isomerase activity
TP50_17125	COG3039	Transposase
TP50_17140	COG4695	Portal protein
TP50_17165	COG2801	Transposase and inactivated derivatives
TP50_17170	COG2963	transposase activity
TP50_17295	COG0473	3-isopropylmalate dehydrogenase activity
TP50_17310	COG4783	chaperone-mediated protein folding
TP50_17325	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TP50_17335	COG0438	transferase activity, transferring glycosyl groups
TP50_17340	COG0671	phosphoesterase, PA-phosphatase related
TP50_17345	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TP50_17360	COG2833	Protein of unknown function (DUF455)
TP50_17380	COG0285	dihydrofolate synthase activity
TP50_17385	COG0406	alpha-ribazole phosphatase activity
TP50_17405	COG1063	alcohol dehydrogenase
TP50_17415	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TP50_17420	COG4208	sulfate ABC transporter
TP50_17425	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
TP50_17430	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
TP50_17435	COG0156	8-amino-7-oxononanoate synthase activity
TP50_17465	COG0604	alcohol dehydrogenase
TP50_17470	COG1902	pentaerythritol trinitrate reductase activity
TP50_17470	COG0446	pyridine nucleotide-disulphide oxidoreductase
TP50_17495	COG0625	glutathione transferase activity
TP50_17500	COG0039	L-malate dehydrogenase activity
TP50_17505	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TP50_17520	COG0154	amidase activity
TP50_17545	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TP50_17560	COG0203	ribosomal protein L17
TP50_17565	COG0202	RNA polymerase activity
TP50_17570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TP50_17575	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TP50_17580	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TP50_17585	COG0201	protein transport
TP50_17590	COG0200	Binds to the 23S rRNA
TP50_17595	COG1841	ribosomal large subunit assembly
TP50_17600	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TP50_17605	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TP50_17610	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TP50_17615	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TP50_17620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TP50_17625	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TP50_17630	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TP50_17635	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TP50_17640	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TP50_17645	COG0255	Belongs to the universal ribosomal protein uL29 family
TP50_17650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TP50_17655	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TP50_17660	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TP50_17665	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TP50_17670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TP50_17675	COG0089	rRNA binding
TP50_17680	COG0088	Forms part of the polypeptide exit tunnel
TP50_17685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TP50_17690	COG0051	transcription antitermination factor activity, RNA binding
TP50_17695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TP50_17700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TP50_17705	COG0049	tRNA binding
TP50_17710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TP50_17715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TP50_17720	COG0085	RNA polymerase activity
TP50_17725	COG0222	ribosome binding
TP50_17730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TP50_17735	COG0081	regulation of translation
TP50_17740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TP50_17745	COG0250	Participates in transcription elongation, termination and antitermination
TP50_17750	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TP50_17760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TP50_17780	COG0012	GTP binding
TP50_17785	COG0193	aminoacyl-tRNA hydrolase activity
TP50_17790	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TP50_17795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TP50_17805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TP50_17810	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
TP50_17820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TP50_17825	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TP50_17835	COG0521	Mo-molybdopterin cofactor biosynthetic process
TP50_17850	COG1254	Belongs to the acylphosphatase family
TP50_17855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TP50_17860	COG1295	ribonuclease BN
TP50_17890	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TP50_17895	COG1404	Belongs to the peptidase S8 family
TP50_17905	COG1404	Belongs to the peptidase S8 family
TP50_17910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TP50_17925	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TP50_17930	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TP50_17950	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TP50_17955	COG3039	Transposase
TP50_17990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TP50_17990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TP50_18010	COG2890	protein-(glutamine-N5) methyltransferase activity
TP50_18020	COG3634	alkyl hydroperoxide reductase activity
TP50_18025	COG0583	DNA-binding transcription factor activity
TP50_18030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TP50_18035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TP50_18045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TP50_18055	COG2197	response regulator
TP50_18065	COG0745	RESPONSE REGULATOR receiver
TP50_18065	COG3706	GGDEF domain
TP50_18080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TP50_18090	COG0697	spore germination
TP50_18115	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
TP50_18145	COG1024	Enoyl-CoA hydratase
TP50_18155	COG3039	Transposase
TP50_18180	COG2155	Conserved Protein
TP50_18185	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TP50_18195	COG3039	Transposase
TP50_18230	COG1132	(ABC) transporter
TP50_18255	COG1538	Outer membrane efflux protein
TP50_18260	COG0745	RESPONSE REGULATOR receiver
TP50_18265	COG5002	protein histidine kinase activity
TP50_18265	COG5000	phosphorelay sensor kinase activity
TP50_18270	COG0475	glutathione-regulated potassium exporter activity
TP50_18275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TP50_18280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TP50_18320	COG1187	pseudouridine synthase activity
TP50_18325	COG5001	Diguanylate cyclase
TP50_18325	COG5002	protein histidine kinase activity
TP50_18370	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TP50_18435	COG2963	transposase activity
TP50_18440	COG2801	Transposase and inactivated derivatives
TP50_18445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TP50_18455	COG1862	Preprotein translocase
TP50_18460	COG0343	queuine tRNA-ribosyltransferase activity
TP50_18465	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TP50_18505	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TP50_18510	COG3291	Pkd domain containing protein
TP50_18520	COG0405	Gamma-glutamyltransferase
TP50_18525	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TP50_18540	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TP50_18545	COG0742	ribosomal rna small subunit methyltransferase
TP50_18550	COG0326	Molecular chaperone. Has ATPase activity
TP50_18560	COG3039	Transposase
TP50_18650	COG0531	amino acid
TP50_18665	COG0006	proline dipeptidase activity
TP50_18675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TP50_18690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP50_18695	COG3938	Belongs to the proline racemase family
TP50_18705	COG0552	protein localization to endoplasmic reticulum
TP50_18710	COG1194	a g-specific adenine glycosylase
TP50_18715	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TP50_18720	COG0784	Response regulator, receiver
TP50_18720	COG4191	Histidine kinase
TP50_18735	COG0322	excinuclease ABC activity
TP50_18750	COG3040	lipid binding
TP50_18760	COG1960	acyl-CoA dehydrogenase activity
TP50_18770	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TP50_18790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TP50_18795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TP50_18800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TP50_18835	COG0438	transferase activity, transferring glycosyl groups
TP50_18840	COG0438	transferase activity, transferring glycosyl groups
TP50_18885	COG0776	regulation of translation
TP50_18890	COG0072	phenylalanine-tRNA ligase activity
TP50_18890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TP50_18895	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TP50_18900	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TP50_18905	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TP50_18910	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TP50_18915	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TP50_18930	COG3039	Transposase
TP50_18935	COG3039	Transposase
TP50_18940	COG1874	Beta-galactosidase
TP50_18940	COG0366	Alpha amylase catalytic
TP50_18945	COG2211	Major facilitator Superfamily
TP50_18945	COG2190	(PTS) system
TP50_18955	COG1082	Xylose isomerase domain protein TIM barrel
TP50_19005	COG3505	Type IV secretory pathway VirD4
TP50_19020	COG0556	nucleotide-excision repair
TP50_19075	COG1611	Belongs to the LOG family
TP50_19085	COG2095	MarC family integral membrane protein
TP50_19095	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TP50_19100	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TP50_19130	COG1185	polyribonucleotide nucleotidyltransferase activity
TP50_19135	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TP50_19140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TP50_19145	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TP50_19150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TP50_19155	COG0195	Participates in both transcription termination and antitermination
TP50_19160	COG0779	Required for maturation of 30S ribosomal subunits
TP50_19170	COG1007	ATP synthesis coupled electron transport
TP50_19185	COG0713	ATP synthesis coupled electron transport
TP50_19195	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TP50_19200	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TP50_19210	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TP50_19215	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TP50_19220	COG0649	NAD binding
TP50_19225	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TP50_19230	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TP50_19235	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TP50_19250	COG0149	triose-phosphate isomerase activity
TP50_19290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TP50_19295	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TP50_19300	COG0159	tryptophan synthase activity
TP50_19310	COG0133	tryptophan synthase activity
TP50_19320	COG3039	Transposase
TP50_19325	COG0135	phosphoribosylanthranilate isomerase activity
TP50_19330	COG0101	tRNA pseudouridine synthase activity
TP50_19350	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TP50_19355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TP50_19360	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TP50_19365	COG2890	protein-(glutamine-N5) methyltransferase activity
TP50_19375	COG0688	phosphatidylethanolamine metabolic process
TP50_19385	COG0433	COG0433 Predicted ATPase
TP50_19390	COG0494	nUDIX hydrolase
TP50_19415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TP50_19420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TP50_19445	COG0717	Belongs to the dCTP deaminase family
TP50_19450	COG0489	protein tyrosine kinase activity
TP50_19455	COG4206	TonB-dependent receptor
TP50_19470	COG3590	peptidase
TP50_19475	COG3590	peptidase
TP50_19500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TP50_19505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TP50_19510	COG2311	Membrane
TP50_19515	COG1047	Peptidyl-prolyl cis-trans
TP50_19520	COG0791	NLP P60 protein
TP50_19525	COG0791	NLP P60 protein
TP50_19535	COG4106	trans-aconitate 2-methyltransferase activity
TP50_19540	COG1301	dicarboxylic acid transport
TP50_19545	COG1785	Belongs to the alkaline phosphatase family
TP50_19550	COG0037	tRNA processing
TP50_19555	COG1722	exodeoxyribonuclease VII activity
TP50_19560	COG0142	geranyltranstransferase activity
TP50_19575	COG0312	modulator of DNA gyrase
TP50_19580	COG3028	Belongs to the UPF0307 family
TP50_19585	COG0312	modulator of DNA gyrase
TP50_19595	COG3164	Protein of unknown function
TP50_19600	COG1530	ribonuclease E activity
TP50_19605	COG0424	maF-like protein
TP50_19610	COG2968	Membrane
TP50_19625	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TP50_19640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TP50_19655	COG0495	leucyl-tRNA aminoacylation
TP50_19665	COG3118	belongs to the thioredoxin family
TP50_19695	COG3039	Transposase
TP50_19705	COG2951	lytic endotransglycosylase activity
TP50_19710	COG4644	lycopene metabolic process
TP50_19730	COG2963	transposase activity
TP50_19735	COG2801	Transposase and inactivated derivatives
TP50_19765	COG3039	Transposase
TP50_19775	COG0583	DNA-binding transcription factor activity
TP50_19780	COG3384	dioxygenase
TP50_19810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TP50_19815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TP50_19855	COG1196	nuclear chromosome segregation
TP50_19900	COG1754	DNA topoisomerase type I activity
TP50_19900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TP50_19905	COG0009	L-threonylcarbamoyladenylate synthase
TP50_19920	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_19930	COG0616	signal peptide processing
TP50_19935	COG0534	Mate efflux family protein
TP50_19955	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TP50_19960	COG0625	glutathione transferase activity
TP50_19975	COG1252	NADH dehydrogenase
TP50_19980	COG2860	membrane
TP50_19985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TP50_19990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TP50_19995	COG2201	protein-glutamate methylesterase activity
TP50_20000	COG2177	Part of the ABC transporter FtsEX involved in
TP50_20005	COG2884	Cell division ATP-binding protein ftsE
TP50_20010	COG0513	Belongs to the DEAD box helicase family
TP50_20015	COG3118	belongs to the thioredoxin family
TP50_20020	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TP50_20030	COG0583	DNA-binding transcription factor activity
TP50_20050	COG1652	LysM domain
TP50_20055	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TP50_20055	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TP50_20060	COG1473	amidohydrolase
TP50_20065	COG3039	Transposase
TP50_20070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP50_20075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TP50_20095	COG5383	Protein conserved in bacteria
TP50_20140	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
TP50_20145	COG3023	N-Acetylmuramoyl-L-alanine amidase
TP50_20155	COG4948	Mandelate Racemase Muconate Lactonizing
TP50_20165	COG0531	amino acid
TP50_20180	COG4682	membrane
TP50_20185	COG2133	pyrroloquinoline quinone binding
TP50_20195	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TP50_20200	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TP50_20205	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TP50_20210	COG1610	YqeY-like protein
TP50_20215	COG1295	ribonuclease BN
TP50_20220	COG0358	DNA primase activity
TP50_20235	COG0109	protoheme IX farnesyltransferase activity
TP50_20265	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
TP50_20280	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TP50_20335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TP50_20340	COG0739	heme binding
TP50_20345	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TP50_20355	COG2223	nitrite transmembrane transporter activity
TP50_20360	COG0708	Exodeoxyribonuclease III
TP50_20365	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TP50_20375	COG1192	Involved in chromosome partitioning
TP50_20380	COG1475	DNA binding
TP50_20395	COG0463	Glycosyl transferase, family 2
TP50_20415	COG0756	dUTP diphosphatase activity
TP50_20420	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TP50_20425	COG2003	Belongs to the UPF0758 family
TP50_20430	COG0018	arginyl-trna synthetase
TP50_20445	COG4221	oxidoreductase activity
TP50_20450	COG2755	lipolytic protein G-D-S-L family
TP50_20450	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TP50_20460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TP50_20465	COG1166	arginine decarboxylase activity
TP50_20470	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TP50_20495	COG3291	Pkd domain containing protein
TP50_20495	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TP50_20510	COG0606	chelatase, subunit chli
TP50_20525	COG4943	cyclic-guanylate-specific phosphodiesterase activity
TP50_20560	COG1690	Belongs to the RtcB family
TP50_20600	COG1090	epimerase
TP50_20605	COG0745	RESPONSE REGULATOR receiver
TP50_20610	COG0642	Histidine kinase
TP50_20645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TP50_20670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TP50_20675	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TP50_20690	COG0753	catalase activity
TP50_20705	COG2197	response regulator
TP50_20710	COG4585	Histidine kinase
TP50_20715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP50_20720	COG1136	(ABC) transporter
TP50_20745	COG0697	spore germination
TP50_20760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TP50_20765	COG0180	Tryptophanyl-tRNA synthetase
TP50_20770	COG3237	CsbD-like
TP50_20810	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TP50_20890	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TP50_20980	COG4373	Mu-like prophage FluMu protein gp28
TP50_21075	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TP50_21080	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TP50_21080	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TP50_21105	COG2205	protein histidine kinase activity
TP50_21110	COG0745	RESPONSE REGULATOR receiver
TP50_21120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TP50_21145	COG1199	ATP-dependent helicase activity
TP50_21160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TP50_21215	COG3039	Transposase
TP50_21260	COG1476	TRANSCRIPTIONal
TP50_21280	COG1230	cation diffusion facilitator family transporter
TP50_21285	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TP50_21290	COG1131	(ABC) transporter
TP50_21295	COG0842	Transport permease protein
TP50_21300	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TP50_21345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TP50_21350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TP50_21360	COG1042	CoA-binding domain protein
TP50_21360	COG0045	succinate-CoA ligase (ADP-forming) activity
TP50_21360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TP50_21365	COG2239	Acts as a magnesium transporter
TP50_21380	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TP50_21385	COG3387	PFAM Glycoside hydrolase 15-related
TP50_21405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TP50_21415	COG0463	Glycosyl transferase, family 2
TP50_21425	COG3039	Transposase
TP50_21430	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_21465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TP50_21480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TP50_21505	COG0823	Involved in the tonB-independent uptake of proteins
TP50_21505	COG4946	Tricorn protease homolog
TP50_21505	COG1506	peptidase
TP50_21520	COG0408	coproporphyrinogen oxidase activity
TP50_21560	COG0515	serine threonine protein kinase
TP50_21565	COG0631	protein serine/threonine phosphatase activity
TP50_21590	COG0667	Aldo Keto reductase
TP50_21595	COG0583	DNA-binding transcription factor activity
TP50_21610	COG3501	Rhs element vgr protein
TP50_21635	COG1595	DNA-templated transcription, initiation
TP50_21745	COG0210	DNA helicase
TP50_21755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP50_21760	COG0583	DNA-binding transcription factor activity
TP50_21765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TP50_21775	COG2159	amidohydrolase
TP50_21780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TP50_21785	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TP50_21800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TP50_21820	COG0357	Ribosomal RNA small subunit methyltransferase G
TP50_21825	COG3540	Alkaline phosphatase
TP50_21835	COG2091	lysine biosynthetic process via aminoadipic acid
TP50_21855	COG0708	Exodeoxyribonuclease III
TP50_21880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TP50_21890	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TP50_21895	COG3162	membrane
TP50_21905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TP50_21935	COG3507	Belongs to the glycosyl hydrolase 43 family
TP50_21940	COG3039	Transposase
TP50_21960	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_21965	COG0179	Fumarylacetoacetate (FAA) hydrolase
TP50_21970	COG4948	Mandelate Racemase Muconate Lactonizing
TP50_21975	COG3254	rhamnose metabolic process
TP50_21985	COG1414	Transcriptional regulator
TP50_21990	COG1971	Probably functions as a manganese efflux pump
TP50_21995	COG2205	protein histidine kinase activity
TP50_22005	COG3459	Glycosyltransferase 36 associated
TP50_22010	COG2211	Major facilitator Superfamily
TP50_22015	COG3265	gluconokinase activity
TP50_22020	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TP50_22040	COG2911	Protein conserved in bacteria
TP50_22045	COG0729	surface antigen
TP50_22065	COG3039	Transposase
TP50_22085	COG3039	Transposase
TP50_22105	COG3039	Transposase
TP50_22120	COG0752	glycyl-tRNA synthetase alpha subunit
TP50_22125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TP50_22135	COG0519	Catalyzes the synthesis of GMP from XMP
TP50_22135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TP50_22145	COG0805	protein transport
TP50_22150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TP50_22155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TP50_22165	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TP50_22185	COG2974	May be involved in recombination
TP50_22190	COG0037	tRNA processing
TP50_22195	COG2115	Belongs to the xylose isomerase family
TP50_22205	COG3661	Belongs to the glycosyl hydrolase 67 family
TP50_22215	COG4948	Mandelate Racemase Muconate Lactonizing
TP50_22225	COG1472	Belongs to the glycosyl hydrolase 3 family
TP50_22230	COG0246	Mannitol dehydrogenase
TP50_22270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TP50_22295	COG3386	PFAM SMP-30 Gluconolaconase
TP50_22305	COG3250	beta-galactosidase activity
TP50_22310	COG1904	glucuronate isomerase
TP50_22315	COG3693	PFAM glycoside hydrolase, family 10
TP50_22330	COG3693	PFAM glycoside hydrolase, family 10
TP50_22345	COG2211	Major facilitator Superfamily
TP50_22380	COG3321	synthase
TP50_22380	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_22380	COG0604	alcohol dehydrogenase
TP50_22385	COG2937	Belongs to the GPAT DAPAT family
TP50_22420	COG0284	orotidine-5'-phosphate decarboxylase activity
TP50_22425	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
TP50_22430	COG3132	Protein of unknown function, DUF480
TP50_22445	COG0210	DNA helicase
TP50_22450	COG3039	Transposase
TP50_22455	COG1435	thymidine kinase activity
TP50_22465	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
TP50_22475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TP50_22505	COG3135	benzoate transporter
TP50_22525	COG0676	glucose-6-phosphate 1-epimerase activity
TP50_22535	COG3012	SEC-C Motif Domain Protein
TP50_22540	COG0730	response to heat
TP50_22550	COG3039	Transposase
TP50_22565	COG0302	gtp cyclohydrolase
TP50_22580	COG1566	PFAM secretion protein HlyD family protein
TP50_22590	COG1289	transmembrane transporter activity
TP50_22595	COG0477	Major facilitator Superfamily
TP50_22605	COG0583	DNA-binding transcription factor activity
TP50_22610	COG4221	oxidoreductase activity
TP50_22620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP50_22625	COG3039	Transposase
TP50_22670	COG0439	Biotin carboxylase
TP50_22695	COG1028	Short-chain dehydrogenase reductase Sdr
TP50_22725	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TP50_22735	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TP50_22785	COG1127	ABC transporter
TP50_22790	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TP50_22795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TP50_22810	COG2853	Lipoprotein
TP50_22855	COG0625	glutathione transferase activity
TP50_22865	COG0531	amino acid
TP50_22870	COG3537	Alpha-1,2-mannosidase
TP50_22880	COG3706	GGDEF domain
TP50_22885	COG3835	regulator
TP50_22890	COG1929	Belongs to the glycerate kinase type-1 family
TP50_22895	COG2271	Major facilitator Superfamily
TP50_22910	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TP50_22915	COG0861	Integral membrane protein TerC family
TP50_22925	COG0584	glycerophosphoryl diester phosphodiesterase
TP50_22940	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TP50_22955	COG0706	membrane insertase activity
TP50_22960	COG0594	ribonuclease P activity
TP50_22965	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TP50_22985	COG2948	multi-organism process
TP50_22990	COG3504	Conjugal transfer protein
TP50_23045	COG1192	Involved in chromosome partitioning
TP50_23105	COG3077	Addiction module antitoxin, RelB DinJ family
TP50_23110	COG3041	Addiction module toxin RelE StbE family
TP50_23170	COG4453	Protein conserved in bacteria
TP50_23190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TP50_23255	COG2337	Toxic component of a toxin-antitoxin (TA) module
TP50_23315	COG3504	Conjugal transfer protein
TP50_23355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol