locus-tag	class	description
CLM98_00010	COG3135	benzoate transporter
CLM98_00030	COG0676	glucose-6-phosphate 1-epimerase activity
CLM98_00040	COG3012	SEC-C Motif Domain Protein
CLM98_00045	COG0730	response to heat
CLM98_00065	COG0302	gtp cyclohydrolase
CLM98_00080	COG1566	PFAM secretion protein HlyD family protein
CLM98_00090	COG1289	transmembrane transporter activity
CLM98_00095	COG0477	Major facilitator Superfamily
CLM98_00105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLM98_00125	COG4691	Plasmid stability protein
CLM98_00130	COG1487	ribonuclease activity
CLM98_00155	COG0564	pseudouridine synthase activity
CLM98_00185	COG0439	Biotin carboxylase
CLM98_00225	COG1074	ATP-dependent DNA helicase activity
CLM98_00230	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CLM98_00245	COG1127	ABC transporter
CLM98_00250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CLM98_00255	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CLM98_00270	COG2853	Lipoprotein
CLM98_00280	COG0386	Belongs to the glutathione peroxidase family
CLM98_00290	COG1322	Protein conserved in bacteria
CLM98_00295	COG0604	alcohol dehydrogenase
CLM98_00300	COG0583	DNA-binding transcription factor activity
CLM98_00315	COG0625	glutathione transferase activity
CLM98_00325	COG0531	amino acid
CLM98_00330	COG3537	Alpha-1,2-mannosidase
CLM98_00345	COG3706	GGDEF domain
CLM98_00350	COG3835	regulator
CLM98_00355	COG1929	Belongs to the glycerate kinase type-1 family
CLM98_00360	COG2271	Major facilitator Superfamily
CLM98_00375	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CLM98_00385	COG0861	Integral membrane protein TerC family
CLM98_00400	COG0584	glycerophosphoryl diester phosphodiesterase
CLM98_00415	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CLM98_00420	COG0726	polysaccharide deacetylase
CLM98_00425	COG0706	membrane insertase activity
CLM98_00430	COG0594	ribonuclease P activity
CLM98_00435	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CLM98_00445	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLM98_00455	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLM98_00460	COG0187	DNA topoisomerase II activity
CLM98_00470	COG0501	Belongs to the peptidase M48B family
CLM98_00500	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CLM98_00510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLM98_00555	COG0793	Belongs to the peptidase S41A family
CLM98_00560	COG4942	peptidase
CLM98_00570	COG2234	aminopeptidase activity
CLM98_00580	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CLM98_00590	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CLM98_00600	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CLM98_00610	COG1064	alcohol dehydrogenase
CLM98_00615	COG0493	'glutamate synthase
CLM98_00620	COG0069	glutamate synthase activity
CLM98_00620	COG0070	glutamate synthase
CLM98_00620	COG0067	glutamate synthase
CLM98_00670	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLM98_00685	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CLM98_00690	COG0438	transferase activity, transferring glycosyl groups
CLM98_00690	COG0297	glycogen (starch) synthase activity
CLM98_00710	COG0367	asparagine synthase
CLM98_00740	COG1132	(ABC) transporter
CLM98_00865	COG1205	dead DEAH box helicase
CLM98_00865	COG1111	helicase
CLM98_00870	COG1272	protein, Hemolysin III
CLM98_00890	COG0300	oxidoreductase activity
CLM98_00895	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_00920	COG2249	NAD(P)H dehydrogenase (quinone) activity
CLM98_00985	COG3237	CsbD-like
CLM98_01035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLM98_01045	COG0477	Major facilitator Superfamily
CLM98_01085	COG0714	Associated with various cellular activities
CLM98_01115	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CLM98_01125	COG4772	TonB-dependent receptor
CLM98_01135	COG0662	Cupin 2, conserved barrel domain protein
CLM98_01140	COG1012	belongs to the aldehyde dehydrogenase family
CLM98_01165	COG1304	FMN binding
CLM98_01180	COG4585	Histidine kinase
CLM98_01185	COG2197	response regulator
CLM98_01205	COG3710	Transcriptional regulator
CLM98_01210	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CLM98_01285	COG0366	Alpha amylase catalytic
CLM98_01290	COG0366	Alpha amylase catalytic
CLM98_01295	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CLM98_01315	COG0657	acetylesterase activity
CLM98_01315	COG2755	lipolytic protein G-D-S-L family
CLM98_01325	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLM98_01340	COG3507	Belongs to the glycosyl hydrolase 43 family
CLM98_01345	COG1609	Transcriptional regulator
CLM98_01355	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CLM98_01360	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_01370	COG2755	lipolytic protein G-D-S-L family
CLM98_01385	COG3186	Phenylalanine-4-hydroxylase
CLM98_01390	COG1522	sequence-specific DNA binding
CLM98_01400	COG1752	Esterase of the alpha-beta hydrolase superfamily
CLM98_01410	COG1119	ATPase activity
CLM98_01425	COG1125	glycine betaine transport
CLM98_01440	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CLM98_01460	COG1396	sequence-specific DNA binding
CLM98_01485	COG0489	protein tyrosine kinase activity
CLM98_01490	COG2062	phosphohistidine phosphatase, SixA
CLM98_01500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLM98_01545	COG1968	undecaprenyl-diphosphatase activity
CLM98_01555	COG0174	glutamine synthetase
CLM98_01560	COG0347	Belongs to the P(II) protein family
CLM98_01565	COG0004	ammonium transporteR
CLM98_01570	COG3852	Histidine kinase
CLM98_01575	COG2204	response regulator
CLM98_01580	COG2032	superoxide dismutase activity
CLM98_01585	COG2032	superoxide dismutase activity
CLM98_01595	COG0346	lactoylglutathione lyase activity
CLM98_01605	COG0183	Belongs to the thiolase family
CLM98_01640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CLM98_01645	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CLM98_01650	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CLM98_01665	COG0028	Belongs to the TPP enzyme family
CLM98_01670	COG2205	protein histidine kinase activity
CLM98_01695	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CLM98_01710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLM98_01720	COG0596	Alpha beta hydrolase
CLM98_01730	COG0318	PFAM AMP-dependent synthetase and ligase
CLM98_01735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLM98_01750	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLM98_01765	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CLM98_01775	COG0564	pseudouridine synthase activity
CLM98_01800	COG0339	signal peptide processing
CLM98_01830	COG0475	glutathione-regulated potassium exporter activity
CLM98_01835	COG0583	DNA-binding transcription factor activity
CLM98_01840	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CLM98_01845	COG2224	Isocitrate lyase
CLM98_01850	COG3706	GGDEF domain
CLM98_01880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CLM98_01885	COG1960	acyl-CoA dehydrogenase activity
CLM98_01945	COG0523	cobalamin synthesis protein
CLM98_01955	COG0697	spore germination
CLM98_01965	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CLM98_01970	COG1846	Transcriptional regulator
CLM98_01975	COG1764	response to oxidative stress
CLM98_02005	COG2130	NADP-dependent
CLM98_02020	COG1187	pseudouridine synthase activity
CLM98_02035	COG1643	Atp-dependent helicase
CLM98_02045	COG4807	Protein conserved in bacteria
CLM98_02050	COG2351	hydroxyisourate hydrolase activity
CLM98_02055	COG2072	flavoprotein involved in K transport
CLM98_02075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CLM98_02110	COG1957	nucleoside hydrolase
CLM98_02120	COG2252	PERMEase
CLM98_02145	COG0084	hydrolase, TatD family'
CLM98_02160	COG0583	DNA-binding transcription factor activity
CLM98_02165	COG2814	Major facilitator Superfamily
CLM98_02180	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CLM98_02185	COG1902	pentaerythritol trinitrate reductase activity
CLM98_02205	COG0745	RESPONSE REGULATOR receiver
CLM98_02210	COG2205	protein histidine kinase activity
CLM98_02215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLM98_02225	COG1538	Outer membrane efflux protein
CLM98_02235	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CLM98_02240	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLM98_02245	COG0583	DNA-binding transcription factor activity
CLM98_02280	COG0702	epimerase
CLM98_02285	COG1733	regulation of RNA biosynthetic process
CLM98_02320	COG0129	dihydroxy-acid dehydratase activity
CLM98_02335	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CLM98_02390	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CLM98_02395	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CLM98_02420	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CLM98_02425	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CLM98_02435	COG3485	protocatechuate 3,4-dioxygenase
CLM98_02440	COG3485	protocatechuate 3,4-dioxygenase
CLM98_02450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CLM98_02455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CLM98_02465	COG1414	Transcriptional regulator
CLM98_02485	COG0445	tRNA wobble uridine modification
CLM98_02525	COG2267	carboxylic ester hydrolase activity
CLM98_02535	COG0156	8-amino-7-oxononanoate synthase activity
CLM98_02540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLM98_02545	COG1040	competence protein
CLM98_02550	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CLM98_02640	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLM98_02710	COG3264	Mechanosensitive ion channel
CLM98_02710	COG1511	domain protein
CLM98_02715	COG1368	sulfuric ester hydrolase activity
CLM98_02725	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CLM98_02730	COG2354	Protein conserved in bacteria
CLM98_02735	COG3706	GGDEF domain
CLM98_02735	COG0745	RESPONSE REGULATOR receiver
CLM98_02740	COG0297	glycogen (starch) synthase activity
CLM98_02745	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CLM98_02750	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CLM98_02775	COG0702	epimerase
CLM98_02780	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_02785	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_02820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLM98_02825	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_02835	COG0513	Belongs to the DEAD box helicase family
CLM98_02855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CLM98_02865	COG3483	tryptophan 2,3-dioxygenase activity
CLM98_02870	COG3104	oligopeptide transport
CLM98_02895	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CLM98_02915	COG1320	monovalent cation:proton antiporter activity
CLM98_02920	COG2212	antiporter activity
CLM98_02930	COG0651	ATP synthesis coupled electron transport
CLM98_02935	COG1006	Multisubunit Na H antiporter MnhC subunit
CLM98_02940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CLM98_02940	COG2111	Na H antiporter
CLM98_02965	COG3179	chitinase
CLM98_02985	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CLM98_02990	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CLM98_03005	COG0456	acetyltransferase
CLM98_03010	COG1597	lipid kinase activity
CLM98_03035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLM98_03040	COG0134	indole-3-glycerol-phosphate synthase activity
CLM98_03050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLM98_03055	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CLM98_03065	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CLM98_03070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CLM98_03075	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CLM98_03090	COG1051	belongs to the nudix hydrolase family
CLM98_03130	COG0316	Belongs to the HesB IscA family
CLM98_03160	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CLM98_03180	COG2814	Major facilitator Superfamily
CLM98_03185	COG0583	DNA-binding transcription factor activity
CLM98_03190	COG2814	Major facilitator Superfamily
CLM98_03195	COG1289	transmembrane transporter activity
CLM98_03205	COG0151	Belongs to the GarS family
CLM98_03215	COG0138	bifunctional purine biosynthesis protein purh
CLM98_03220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLM98_03225	COG2267	carboxylic ester hydrolase activity
CLM98_03230	COG0671	phosphoesterase, PA-phosphatase related
CLM98_03230	COG2453	phosphatase
CLM98_03255	COG4589	Belongs to the CDS family
CLM98_03260	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CLM98_03280	COG2264	protein methyltransferase activity
CLM98_03305	COG0439	Biotin carboxylase
CLM98_03315	COG0511	ligase activity, forming carbon-carbon bonds
CLM98_03320	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CLM98_03330	COG1324	tolerance protein
CLM98_03360	COG0300	oxidoreductase activity
CLM98_03365	COG2356	endonuclease I
CLM98_03375	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CLM98_03380	COG0459	protein refolding
CLM98_03395	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CLM98_03410	COG3386	PFAM SMP-30 Gluconolaconase
CLM98_03420	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CLM98_03425	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CLM98_03445	COG0778	Nitroreductase
CLM98_03450	COG2353	YceI-like domain
CLM98_03480	COG3052	prosthetic group binding
CLM98_03500	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CLM98_03505	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CLM98_03515	COG1802	Transcriptional regulator
CLM98_03570	COG4221	oxidoreductase activity
CLM98_03585	COG4221	oxidoreductase activity
CLM98_03595	COG0435	Glutathione S-transferase
CLM98_03620	COG2409	Drug exporters of the RND superfamily
CLM98_03630	COG1506	peptidase
CLM98_03630	COG0823	Involved in the tonB-independent uptake of proteins
CLM98_03645	COG3706	GGDEF domain
CLM98_03675	COG0697	spore germination
CLM98_03690	COG1113	amino acid transport
CLM98_03710	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CLM98_03760	COG5001	Diguanylate cyclase
CLM98_03765	COG0840	transmembrane signaling receptor activity
CLM98_03770	COG5297	Belongs to the glycosyl hydrolase family 6
CLM98_03770	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CLM98_03775	COG0659	secondary active sulfate transmembrane transporter activity
CLM98_03785	COG3706	GGDEF domain
CLM98_03805	COG2943	transferase activity, transferring hexosyl groups
CLM98_03815	COG3275	phosphorelay sensor kinase activity
CLM98_03825	COG0181	hydroxymethylbilane synthase activity
CLM98_03855	COG1505	serine-type exopeptidase activity
CLM98_03860	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CLM98_03875	COG2832	Protein of unknown function (DUF454)
CLM98_03885	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CLM98_03895	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CLM98_03900	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CLM98_03905	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CLM98_03930	COG2226	methyltransferase
CLM98_03935	COG3300	MHYT domain
CLM98_03935	COG5001	Diguanylate cyclase
CLM98_03940	COG0308	aminopeptidase N
CLM98_03990	COG3284	Transcriptional regulator
CLM98_04000	COG1077	Cell shape determining protein MreB Mrl
CLM98_04005	COG1792	Involved in formation and maintenance of cell shape
CLM98_04020	COG0772	Belongs to the SEDS family
CLM98_04030	COG2951	lytic endotransglycosylase activity
CLM98_04035	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CLM98_04045	COG1686	Belongs to the peptidase S11 family
CLM98_04055	COG2921	Belongs to the UPF0250 family
CLM98_04060	COG0321	lipoyl(octanoyl) transferase activity
CLM98_04065	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CLM98_04080	COG0583	DNA-binding transcription factor activity
CLM98_04090	COG1056	cytidyltransferase-related domain
CLM98_04090	COG1051	belongs to the nudix hydrolase family
CLM98_04125	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CLM98_04130	COG0673	inositol 2-dehydrogenase activity
CLM98_04135	COG2823	Periplasmic or secreted lipoprotein
CLM98_04140	COG4251	negative regulation of phosphorylation
CLM98_04145	COG0784	Response regulator, receiver
CLM98_04150	COG4191	Histidine kinase
CLM98_04155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CLM98_04215	COG1459	type II secretion system
CLM98_04290	COG1609	Transcriptional regulator
CLM98_04295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CLM98_04300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CLM98_04310	COG0617	tRNA 3'-terminal CCA addition
CLM98_04315	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CLM98_04320	COG1012	belongs to the aldehyde dehydrogenase family
CLM98_04325	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLM98_04340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CLM98_04355	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CLM98_04360	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CLM98_04380	COG2205	protein histidine kinase activity
CLM98_04385	COG0745	RESPONSE REGULATOR receiver
CLM98_04410	COG3791	Glutathione-dependent formaldehyde-activating
CLM98_04425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLM98_04435	COG0697	spore germination
CLM98_04445	COG0488	(ABC) transporter
CLM98_04455	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLM98_04460	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CLM98_04470	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLM98_04470	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLM98_04490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CLM98_04495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLM98_04500	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CLM98_04525	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CLM98_04530	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CLM98_04535	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CLM98_04540	COG2205	protein histidine kinase activity
CLM98_04545	COG0745	RESPONSE REGULATOR receiver
CLM98_04560	COG0277	FAD linked oxidase domain protein
CLM98_04565	COG1988	membrane-bound metal-dependent
CLM98_04570	COG0792	nuclease activity
CLM98_04600	COG2001	Belongs to the MraZ family
CLM98_04605	COG0275	rRNA processing
CLM98_04610	COG3116	cell division
CLM98_04620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLM98_04625	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLM98_04630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLM98_04640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLM98_04645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLM98_04650	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLM98_04655	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CLM98_04670	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CLM98_04680	COG0739	heme binding
CLM98_04685	COG0653	protein targeting
CLM98_04690	COG0494	nUDIX hydrolase
CLM98_04700	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CLM98_04715	COG0604	alcohol dehydrogenase
CLM98_04715	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_04715	COG3321	synthase
CLM98_04745	COG0366	Alpha amylase catalytic
CLM98_04780	COG2226	methyltransferase
CLM98_04785	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CLM98_04795	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CLM98_04840	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CLM98_04850	COG4106	trans-aconitate 2-methyltransferase activity
CLM98_04855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLM98_04865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLM98_04870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CLM98_04880	COG0667	Aldo Keto reductase
CLM98_04890	COG4771	TonB-dependent receptor
CLM98_04910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLM98_04915	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CLM98_04925	COG2175	clavaminate synthase activity
CLM98_04935	COG4181	ATPase activity
CLM98_04950	COG0642	Histidine kinase
CLM98_04965	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CLM98_04985	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CLM98_04990	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CLM98_05005	COG3829	transcription factor binding
CLM98_05015	COG1116	anion transmembrane transporter activity
CLM98_05020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLM98_05030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLM98_05035	COG0431	NADPH-dependent FMN reductase
CLM98_05060	COG0747	negative chemotaxis
CLM98_05080	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CLM98_05085	COG2967	ApaG domain
CLM98_05090	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLM98_05095	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CLM98_05100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLM98_05105	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CLM98_05120	COG0123	including yeast histone deacetylase and acetoin utilization protein
CLM98_05125	COG2096	Adenosyltransferase
CLM98_05140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLM98_05145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLM98_05175	COG3384	dioxygenase
CLM98_05180	COG0583	DNA-binding transcription factor activity
CLM98_05195	COG1024	Enoyl-CoA hydratase
CLM98_05215	COG3386	PFAM SMP-30 Gluconolaconase
CLM98_05230	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CLM98_05255	COG0697	spore germination
CLM98_05265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLM98_05280	COG3706	GGDEF domain
CLM98_05280	COG0745	RESPONSE REGULATOR receiver
CLM98_05285	COG0784	Response regulator, receiver
CLM98_05285	COG2205	protein histidine kinase activity
CLM98_05285	COG5002	protein histidine kinase activity
CLM98_05290	COG2197	response regulator
CLM98_05300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLM98_05310	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CLM98_05315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLM98_05325	COG0583	DNA-binding transcription factor activity
CLM98_05330	COG3634	alkyl hydroperoxide reductase activity
CLM98_05340	COG2890	protein-(glutamine-N5) methyltransferase activity
CLM98_05360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLM98_05360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLM98_05390	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CLM98_05415	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CLM98_05420	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CLM98_05435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLM98_05440	COG1404	Belongs to the peptidase S8 family
CLM98_05450	COG1404	Belongs to the peptidase S8 family
CLM98_05455	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CLM98_05480	COG1295	ribonuclease BN
CLM98_05485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLM98_05505	COG0521	Mo-molybdopterin cofactor biosynthetic process
CLM98_05515	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CLM98_05530	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CLM98_05535	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CLM98_05545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CLM98_05550	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CLM98_05555	COG0193	aminoacyl-tRNA hydrolase activity
CLM98_05560	COG0012	GTP binding
CLM98_05580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLM98_05590	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CLM98_05595	COG0250	Participates in transcription elongation, termination and antitermination
CLM98_05600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CLM98_05605	COG0081	regulation of translation
CLM98_05610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CLM98_05615	COG0222	ribosome binding
CLM98_05620	COG0085	RNA polymerase activity
CLM98_05625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CLM98_05630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CLM98_05635	COG0049	tRNA binding
CLM98_05640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLM98_05645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLM98_05650	COG0051	transcription antitermination factor activity, RNA binding
CLM98_05655	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CLM98_05660	COG0088	Forms part of the polypeptide exit tunnel
CLM98_05665	COG0089	rRNA binding
CLM98_05670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CLM98_05675	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CLM98_05680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CLM98_05685	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CLM98_05690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CLM98_05695	COG0255	Belongs to the universal ribosomal protein uL29 family
CLM98_05700	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CLM98_05705	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CLM98_05710	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CLM98_05715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CLM98_05720	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CLM98_05725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CLM98_05730	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CLM98_05735	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CLM98_05740	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CLM98_05745	COG1841	ribosomal large subunit assembly
CLM98_05750	COG0200	Binds to the 23S rRNA
CLM98_05755	COG0201	protein transport
CLM98_05760	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CLM98_05765	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CLM98_05770	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLM98_05775	COG0202	RNA polymerase activity
CLM98_05780	COG0203	ribosomal protein L17
CLM98_05785	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CLM98_05805	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CLM98_05815	COG0154	amidase activity
CLM98_05830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CLM98_05835	COG0039	L-malate dehydrogenase activity
CLM98_05840	COG0625	glutathione transferase activity
CLM98_05860	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLM98_05860	COG1902	pentaerythritol trinitrate reductase activity
CLM98_05865	COG0604	alcohol dehydrogenase
CLM98_05895	COG0156	8-amino-7-oxononanoate synthase activity
CLM98_05900	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CLM98_05905	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CLM98_05910	COG4208	sulfate ABC transporter
CLM98_05915	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CLM98_05925	COG1063	alcohol dehydrogenase
CLM98_05960	COG0406	alpha-ribazole phosphatase activity
CLM98_05965	COG0285	dihydrofolate synthase activity
CLM98_05985	COG2833	Protein of unknown function (DUF455)
CLM98_05995	COG3291	Pkd domain containing protein
CLM98_06005	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLM98_06010	COG0671	phosphoesterase, PA-phosphatase related
CLM98_06015	COG0438	transferase activity, transferring glycosyl groups
CLM98_06025	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CLM98_06040	COG4783	chaperone-mediated protein folding
CLM98_06055	COG0473	3-isopropylmalate dehydrogenase activity
CLM98_06205	COG0544	peptidyl-prolyl cis-trans isomerase activity
CLM98_06210	COG0740	serine-type endopeptidase activity
CLM98_06215	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CLM98_06245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLM98_06255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLM98_06265	COG0328	RNA-DNA hybrid ribonuclease activity
CLM98_06270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CLM98_06275	COG0631	protein serine/threonine phosphatase activity
CLM98_06290	COG0859	PFAM glycosyl transferase family 9
CLM98_06295	COG3642	lipopolysaccharide core region biosynthetic process
CLM98_06300	COG1234	tRNA 3'-trailer cleavage
CLM98_06305	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CLM98_06315	COG0315	cyclic pyranopterin monophosphate synthase activity
CLM98_06320	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CLM98_06325	COG0314	molybdopterin synthase activity
CLM98_06375	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CLM98_06380	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CLM98_06385	COG0537	adenosine 5'-monophosphoramidase activity
CLM98_06405	COG0714	Associated with various cellular activities
CLM98_06425	COG0424	maF-like protein
CLM98_06430	COG1399	metal-binding, possibly nucleic acid-binding protein
CLM98_06435	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CLM98_06440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLM98_06455	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_06460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLM98_06470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CLM98_06475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CLM98_06500	COG3829	transcription factor binding
CLM98_06520	COG3609	addiction module antidote protein, CC2985 family
CLM98_06555	COG2373	Large extracellular alpha-helical protein
CLM98_06575	COG4953	penicillin-binding protein 1C
CLM98_06585	COG0678	peroxiredoxin activity
CLM98_06605	COG0330	HflC and HflK could
CLM98_06610	COG0330	HflC and HflK could
CLM98_06620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CLM98_06625	COG0308	aminopeptidase N
CLM98_06630	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_06635	COG1309	transcriptional regulator
CLM98_06710	COG0328	RNA-DNA hybrid ribonuclease activity
CLM98_06710	COG0406	alpha-ribazole phosphatase activity
CLM98_06715	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CLM98_06725	COG3387	PFAM Glycoside hydrolase 15-related
CLM98_06730	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_06740	COG3537	Alpha-1,2-mannosidase
CLM98_06760	COG0492	ferredoxin-NADP+ reductase activity
CLM98_06785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CLM98_06790	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CLM98_06795	COG2080	2 iron, 2 sulfur cluster binding
CLM98_06830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLM98_06845	COG0587	DNA-directed DNA polymerase activity
CLM98_06865	COG1297	OPT oligopeptide transporter protein
CLM98_06880	COG1506	peptidase
CLM98_06880	COG0823	Involved in the tonB-independent uptake of proteins
CLM98_06895	COG1917	Cupin 2, conserved barrel domain protein
CLM98_06895	COG2207	Transcriptional regulator
CLM98_06915	COG0753	catalase activity
CLM98_06920	COG0656	L-ascorbic acid biosynthetic process
CLM98_06930	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLM98_06930	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLM98_06935	COG2814	Major facilitator Superfamily
CLM98_06965	COG0745	RESPONSE REGULATOR receiver
CLM98_06970	COG0642	Histidine kinase
CLM98_06980	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CLM98_06985	COG2894	cell division
CLM98_06990	COG0850	regulation of cytokinetic process
CLM98_07005	COG4585	Histidine kinase
CLM98_07010	COG2197	response regulator
CLM98_07025	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CLM98_07055	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CLM98_07065	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CLM98_07085	COG1946	Acyl-CoA thioesterase
CLM98_07100	COG0824	Thioesterase
CLM98_07105	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CLM98_07110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CLM98_07115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CLM98_07120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CLM98_07125	COG0268	Binds directly to 16S ribosomal RNA
CLM98_07135	COG0196	riboflavin kinase activity
CLM98_07140	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CLM98_07145	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CLM98_07150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLM98_07165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CLM98_07170	COG1845	cytochrome c oxidase, subunit III
CLM98_07175	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CLM98_07190	COG3152	Membrane
CLM98_07200	COG2207	Transcriptional regulator
CLM98_07205	COG0326	Molecular chaperone. Has ATPase activity
CLM98_07220	COG1366	Belongs to the anti-sigma-factor antagonist family
CLM98_07225	COG1366	Belongs to the anti-sigma-factor antagonist family
CLM98_07230	COG2172	sigma factor antagonist activity
CLM98_07255	COG4771	TonB-dependent receptor
CLM98_07265	COG5507	3-demethylubiquinone-9 3-methyltransferase
CLM98_07270	COG2205	protein histidine kinase activity
CLM98_07280	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLM98_07285	COG3850	Histidine kinase
CLM98_07285	COG2205	protein histidine kinase activity
CLM98_07285	COG3437	response regulator, receiver
CLM98_07285	COG4999	Histidine kinase
CLM98_07290	COG0784	Response regulator, receiver
CLM98_07290	COG4191	Histidine kinase
CLM98_07315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CLM98_07320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CLM98_07330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLM98_07335	COG0228	four-way junction DNA binding
CLM98_07340	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CLM98_07345	COG0336	Belongs to the RNA methyltransferase TrmD family
CLM98_07350	COG0335	large ribosomal subunit rRNA binding
CLM98_07375	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CLM98_07385	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLM98_07395	COG3209	COG3209 Rhs family protein
CLM98_07420	COG3250	beta-galactosidase activity
CLM98_07425	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CLM98_07445	COG1960	acyl-CoA dehydrogenase activity
CLM98_07450	COG1024	Enoyl-CoA hydratase
CLM98_07470	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLM98_07470	COG1024	Enoyl-CoA hydratase
CLM98_07485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLM98_07490	COG0481	GTPase activity
CLM98_07505	COG0571	ribonuclease III activity
CLM98_07515	COG1381	Involved in DNA repair and RecF pathway recombination
CLM98_07525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CLM98_07535	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CLM98_07540	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CLM98_07545	COG3046	protein related to deoxyribodipyrimidine photolyase
CLM98_07550	COG1472	Belongs to the glycosyl hydrolase 3 family
CLM98_07560	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CLM98_07565	COG1278	Cold shock
CLM98_07570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLM98_07580	COG1201	RNA secondary structure unwinding
CLM98_07585	COG1793	dna ligase
CLM98_07595	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CLM98_07595	COG1793	dna ligase
CLM98_07610	COG0745	RESPONSE REGULATOR receiver
CLM98_07610	COG3706	GGDEF domain
CLM98_07630	COG0183	Belongs to the thiolase family
CLM98_07655	COG1451	nucleotide metabolic process
CLM98_07660	COG5487	UPF0391 membrane protein
CLM98_07670	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CLM98_07685	COG1077	Cell shape determining protein MreB Mrl
CLM98_07690	COG1047	Peptidyl-prolyl cis-trans
CLM98_07700	COG2824	Alkylphosphonate utilization operon protein PhnA
CLM98_07710	COG1902	pentaerythritol trinitrate reductase activity
CLM98_07715	COG2814	Major facilitator Superfamily
CLM98_07750	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CLM98_07750	COG0392	lysyltransferase activity
CLM98_07760	COG0251	oxidation-reduction process
CLM98_07765	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CLM98_07780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CLM98_07805	COG1595	DNA-templated transcription, initiation
CLM98_07825	COG2878	Part of a membrane complex involved in electron transport
CLM98_07835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLM98_07835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLM98_07850	COG1131	(ABC) transporter
CLM98_07855	COG0346	lactoylglutathione lyase activity
CLM98_07860	COG0833	amino acid
CLM98_07865	COG2040	homocysteine
CLM98_07875	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CLM98_07895	COG1695	Transcriptional regulator
CLM98_07930	COG0825	malonyl-CoA metabolic process
CLM98_07940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CLM98_07945	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLM98_07950	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLM98_07955	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLM98_07960	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLM98_07975	COG0750	zinc metalloprotease
CLM98_07980	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CLM98_07985	COG0575	Belongs to the CDS family
CLM98_07990	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CLM98_07995	COG0233	cytoplasmic translational termination
CLM98_08000	COG0528	UMP kinase activity
CLM98_08005	COG0745	RESPONSE REGULATOR receiver
CLM98_08005	COG3706	GGDEF domain
CLM98_08010	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CLM98_08015	COG0052	Belongs to the universal ribosomal protein uS2 family
CLM98_08050	COG0024	Methionine aminopeptidase
CLM98_08055	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CLM98_08065	COG1393	Belongs to the ArsC family
CLM98_08070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLM98_08080	COG0367	asparagine synthase
CLM98_08090	COG4774	siderophore transport
CLM98_08110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CLM98_08140	COG1566	PFAM secretion protein HlyD family protein
CLM98_08145	COG2814	Major facilitator Superfamily
CLM98_08165	COG3104	oligopeptide transport
CLM98_08195	COG0339	signal peptide processing
CLM98_08205	COG0386	Belongs to the glutathione peroxidase family
CLM98_08260	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CLM98_08280	COG1960	acyl-CoA dehydrogenase activity
CLM98_08300	COG0367	asparagine synthase
CLM98_08310	COG0305	Participates in initiation and elongation during chromosome replication
CLM98_08315	COG0415	Belongs to the DNA photolyase family
CLM98_08330	COG0583	DNA-binding transcription factor activity
CLM98_08365	COG3706	GGDEF domain
CLM98_08375	COG3706	GGDEF domain
CLM98_08500	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CLM98_08515	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLM98_08525	COG0497	DNA recombination
CLM98_08530	COG1420	regulation of RNA biosynthetic process
CLM98_08535	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CLM98_08540	COG0443	Heat shock 70 kDa protein
CLM98_08545	COG0484	heat shock protein binding
CLM98_08555	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CLM98_08585	COG0583	DNA-binding transcription factor activity
CLM98_08590	COG1132	(ABC) transporter
CLM98_08625	COG2850	peptidyl-arginine hydroxylation
CLM98_08645	COG1253	flavin adenine dinucleotide binding
CLM98_08675	COG1131	(ABC) transporter
CLM98_08680	COG1725	Transcriptional regulator
CLM98_08690	COG0386	Belongs to the glutathione peroxidase family
CLM98_08705	COG2900	Belongs to the SlyX family
CLM98_08730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLM98_08740	COG1410	methionine synthase
CLM98_08740	COG0646	methionine synthase
CLM98_08745	COG1410	methionine synthase
CLM98_08745	COG0646	methionine synthase
CLM98_08755	COG1960	acyl-CoA dehydrogenase activity
CLM98_08760	COG1960	acyl-CoA dehydrogenase activity
CLM98_08780	COG0557	exoribonuclease II activity
CLM98_08790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLM98_08800	COG3706	GGDEF domain
CLM98_08805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CLM98_08815	COG0704	Plays a role in the regulation of phosphate uptake
CLM98_08820	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLM98_08825	COG0581	inorganic phosphate transmembrane transporter activity
CLM98_08830	COG0573	inorganic phosphate transmembrane transporter activity
CLM98_08835	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CLM98_08860	COG0659	secondary active sulfate transmembrane transporter activity
CLM98_08865	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CLM98_08875	COG1024	Enoyl-CoA hydratase
CLM98_08885	COG0494	nUDIX hydrolase
CLM98_08930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CLM98_08930	COG0116	Belongs to the methyltransferase superfamily
CLM98_08935	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CLM98_08960	COG2925	Exonuclease
CLM98_08970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLM98_08975	COG3844	kynureninase activity
CLM98_08985	COG0662	Cupin 2, conserved barrel domain protein
CLM98_08990	COG0288	reversible hydration of carbon dioxide
CLM98_09055	COG2808	Putative FMN-binding domain
CLM98_09075	COG0017	Asparaginyl-tRNA synthetase
CLM98_09085	COG0316	Belongs to the HesB IscA family
CLM98_09090	COG0360	Binds together with S18 to 16S ribosomal RNA
CLM98_09095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CLM98_09100	COG0359	binds to the 23S rRNA
CLM98_09110	COG3115	cell septum assembly
CLM98_09120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLM98_09125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLM98_09130	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CLM98_09145	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CLM98_09165	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CLM98_09175	COG2986	histidine ammonia-lyase
CLM98_09180	COG1228	amidohydrolase
CLM98_09225	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CLM98_09230	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CLM98_09235	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CLM98_09240	COG1605	Chorismate mutase
CLM98_09240	COG0077	Prephenate dehydratase
CLM98_09245	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CLM98_09260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CLM98_09265	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CLM98_09270	COG0583	DNA-binding transcription factor activity
CLM98_09325	COG0840	transmembrane signaling receptor activity
CLM98_09350	COG5002	protein histidine kinase activity
CLM98_09350	COG2205	protein histidine kinase activity
CLM98_09350	COG0784	Response regulator, receiver
CLM98_09360	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CLM98_09365	COG0784	Response regulator, receiver
CLM98_09365	COG4191	Histidine kinase
CLM98_09380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLM98_09390	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CLM98_09400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CLM98_09415	COG1595	DNA-templated transcription, initiation
CLM98_09470	COG2244	polysaccharide biosynthetic process
CLM98_09505	COG2264	protein methyltransferase activity
CLM98_09515	COG0438	transferase activity, transferring glycosyl groups
CLM98_09530	COG1136	(ABC) transporter
CLM98_09540	COG0477	Major facilitator Superfamily
CLM98_09545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLM98_09560	COG1253	flavin adenine dinucleotide binding
CLM98_09575	COG0306	phosphate transporter
CLM98_09600	COG0504	CTP synthase activity
CLM98_09605	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CLM98_09615	COG0148	phosphopyruvate hydratase activity
CLM98_09620	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CLM98_09625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CLM98_09630	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CLM98_09635	COG0585	pseudouridine synthase activity
CLM98_09640	COG2840	Smr protein MutS2
CLM98_09645	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CLM98_09650	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CLM98_09655	COG1238	metal cluster binding
CLM98_09670	COG1534	Rna-binding protein
CLM98_09675	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CLM98_09680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLM98_09685	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CLM98_09690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CLM98_09695	COG1923	regulation of RNA biosynthetic process
CLM98_09700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CLM98_09705	COG1546	Belongs to the CinA family
CLM98_09715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLM98_09720	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CLM98_09730	COG2137	regulation of response to DNA damage stimulus
CLM98_09735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLM98_09740	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CLM98_09760	COG1741	Belongs to the pirin family
CLM98_09765	COG0583	DNA-binding transcription factor activity
CLM98_09790	COG0352	thiamine-phosphate diphosphorylase activity
CLM98_09790	COG0351	phosphomethylpyrimidine kinase
CLM98_09805	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CLM98_09810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CLM98_09825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLM98_09835	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CLM98_09840	COG3734	2-keto-3-deoxy-galactonokinase
CLM98_09850	COG4948	Mandelate Racemase Muconate Lactonizing
CLM98_09855	COG0800	Aldolase
CLM98_09895	COG1501	Belongs to the glycosyl hydrolase 31 family
CLM98_09905	COG1070	Carbohydrate kinase
CLM98_09910	COG2115	Belongs to the xylose isomerase family
CLM98_09915	COG0477	Major facilitator Superfamily
CLM98_09935	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLM98_09940	COG1469	GTP cyclohydrolase I activity
CLM98_09960	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CLM98_09965	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CLM98_09970	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CLM98_09975	COG0166	Belongs to the GPI family
CLM98_10000	COG1472	Belongs to the glycosyl hydrolase 3 family
CLM98_10015	COG5001	Diguanylate cyclase
CLM98_10015	COG4251	negative regulation of phosphorylation
CLM98_10015	COG3706	GGDEF domain
CLM98_10015	COG2203	Gaf domain
CLM98_10025	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CLM98_10030	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CLM98_10045	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CLM98_10050	COG0671	phosphoesterase, PA-phosphatase related
CLM98_10065	COG1794	racemase activity, acting on amino acids and derivatives
CLM98_10075	COG0697	spore germination
CLM98_10080	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CLM98_10085	COG0167	dihydroorotate dehydrogenase activity
CLM98_10105	COG1012	belongs to the aldehyde dehydrogenase family
CLM98_10120	COG1215	transferase activity, transferring glycosyl groups
CLM98_10125	COG1649	PFAM Uncharacterised BCR, COG1649
CLM98_10125	COG0726	polysaccharide deacetylase
CLM98_10140	COG3210	domain, Protein
CLM98_10150	COG3210	domain, Protein
CLM98_10195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLM98_10200	COG0124	histidyl-tRNA synthetase
CLM98_10210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CLM98_10215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CLM98_10220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLM98_10225	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CLM98_10225	COG0131	Imidazoleglycerol-phosphate dehydratase
CLM98_10230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CLM98_10235	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CLM98_10240	COG0107	imidazoleglycerol-phosphate synthase activity
CLM98_10245	COG0140	phosphoribosyl-ATP diphosphatase activity
CLM98_10245	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CLM98_10260	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CLM98_10265	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CLM98_10270	COG0235	Class ii aldolase
CLM98_10275	COG0531	amino acid
CLM98_10280	COG0531	amino acid
CLM98_10290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CLM98_10295	COG0277	FAD linked oxidase domain protein
CLM98_10315	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CLM98_10360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLM98_10365	COG2258	MOSC domain
CLM98_10370	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CLM98_10375	COG0505	Belongs to the CarA family
CLM98_10385	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CLM98_10390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLM98_10400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLM98_10440	COG3279	Response regulator of the LytR AlgR family
CLM98_10445	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CLM98_10450	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CLM98_10460	COG2198	Histidine kinase
CLM98_10460	COG2205	protein histidine kinase activity
CLM98_10460	COG0784	Response regulator, receiver
CLM98_10465	COG1024	Enoyl-CoA hydratase
CLM98_10470	COG0318	PFAM AMP-dependent synthetase and ligase
CLM98_10500	COG2267	carboxylic ester hydrolase activity
CLM98_10510	COG2201	protein-glutamate methylesterase activity
CLM98_10515	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CLM98_10525	COG0840	transmembrane signaling receptor activity
CLM98_10535	COG0835	chemotaxis
CLM98_10550	COG0840	transmembrane signaling receptor activity
CLM98_10555	COG0840	transmembrane signaling receptor activity
CLM98_10570	COG0840	transmembrane signaling receptor activity
CLM98_10580	COG0840	transmembrane signaling receptor activity
CLM98_10585	COG0840	transmembrane signaling receptor activity
CLM98_10590	COG0840	transmembrane signaling receptor activity
CLM98_10595	COG0840	transmembrane signaling receptor activity
CLM98_10610	COG0840	transmembrane signaling receptor activity
CLM98_10615	COG0840	transmembrane signaling receptor activity
CLM98_10630	COG0643	Histidine kinase
CLM98_10630	COG2198	Histidine kinase
CLM98_10635	COG0745	RESPONSE REGULATOR receiver
CLM98_10645	COG0835	chemotaxis
CLM98_10650	COG1192	Involved in chromosome partitioning
CLM98_10655	COG1360	Flagellar Motor Protein
CLM98_10660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CLM98_10740	COG3002	Belongs to the UPF0753 family
CLM98_10775	COG0641	radical SAM
CLM98_10795	COG0643	Histidine kinase
CLM98_10795	COG2198	Histidine kinase
CLM98_10815	COG0455	bacterial-type flagellum organization
CLM98_10825	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLM98_10840	COG5001	Diguanylate cyclase
CLM98_10840	COG3300	MHYT domain
CLM98_10850	COG5001	Diguanylate cyclase
CLM98_10850	COG3300	MHYT domain
CLM98_10855	COG1684	flagellar biosynthetic protein fliR
CLM98_10860	COG1987	bacterial-type flagellum assembly
CLM98_10870	COG3190	flagellar
CLM98_10920	COG1677	Flagellar hook-basal body complex protein FliE
CLM98_10950	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_10955	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_10960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLM98_10975	COG2204	response regulator
CLM98_10980	COG2201	protein-glutamate methylesterase activity
CLM98_11010	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CLM98_11015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLM98_11020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLM98_11030	COG1705	Flagellar rod assembly protein muramidase FlgJ
CLM98_11030	COG3951	Flagellar rod assembly protein muramidase FlgJ
CLM98_11035	COG1706	bacterial-type flagellum-dependent cell motility
CLM98_11040	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CLM98_11045	COG4786	Flagellar basal body rod
CLM98_11050	COG4787	bacterial-type flagellum-dependent cell motility
CLM98_11055	COG1749	Flagellar hook protein flgE
CLM98_11060	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CLM98_11065	COG1558	bacterial-type flagellum-dependent cell motility
CLM98_11075	COG0784	Response regulator, receiver
CLM98_11075	COG0835	chemotaxis
CLM98_11095	COG5002	protein histidine kinase activity
CLM98_11125	COG2915	High frequency lysogenization protein hflD homolog
CLM98_11130	COG0482	sulfurtransferase activity
CLM98_11140	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CLM98_11145	COG0542	response to heat
CLM98_11150	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CLM98_11155	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CLM98_11165	COG0492	ferredoxin-NADP+ reductase activity
CLM98_11170	COG1674	ftsk spoiiie
CLM98_11180	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CLM98_11190	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLM98_11195	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CLM98_11205	COG0183	Belongs to the thiolase family
CLM98_11210	COG1024	Enoyl-CoA hydratase
CLM98_11210	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLM98_11220	COG0105	UTP biosynthetic process
CLM98_11225	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CLM98_11235	COG1426	Protein conserved in bacteria
CLM98_11245	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLM98_11250	COG1160	GTP binding
CLM98_11255	COG0303	'Molybdopterin
CLM98_11260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CLM98_11300	COG0708	Exodeoxyribonuclease III
CLM98_11310	COG0303	'Molybdopterin
CLM98_11315	COG0746	molybdenum cofactor guanylyltransferase activity
CLM98_11330	COG1914	H( )-stimulated, divalent metal cation uptake system
CLM98_11335	COG1321	iron dependent repressor
CLM98_11340	COG0590	tRNA wobble adenosine to inosine editing
CLM98_11345	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CLM98_11350	COG0668	transmembrane transport
CLM98_11360	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CLM98_11375	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_11380	COG1183	phosphatidylcholine synthase activity
CLM98_11390	COG3243	poly(R)-hydroxyalkanoic acid synthase
CLM98_11405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLM98_11405	COG0723	plastoquinol--plastocyanin reductase activity
CLM98_11415	COG2183	response to ionizing radiation
CLM98_11420	COG0784	Response regulator, receiver
CLM98_11420	COG2205	protein histidine kinase activity
CLM98_11495	COG0800	Aldolase
CLM98_11500	COG0129	dihydroxy-acid dehydratase activity
CLM98_11505	COG0363	glucosamine-6-phosphate deaminase activity
CLM98_11510	COG0837	glucose binding
CLM98_11515	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CLM98_11540	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CLM98_11555	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CLM98_11560	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CLM98_11570	COG4591	ABC-type transport system involved in lipoprotein release permease component
CLM98_11575	COG1136	(ABC) transporter
CLM98_11590	COG0811	peptide transport
CLM98_11600	COG1132	(ABC) transporter
CLM98_11605	COG1663	tetraacyldisaccharide 4'-kinase activity
CLM98_11610	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CLM98_11615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CLM98_11625	COG0322	excinuclease ABC activity
CLM98_11630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLM98_11650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLM98_11655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLM98_11670	COG0582	viral genome integration into host DNA
CLM98_11680	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CLM98_11710	COG1530	ribonuclease E activity
CLM98_11720	COG3064	Membrane
CLM98_11725	COG0428	transporter
CLM98_11735	COG2154	pterin-4-alpha-carbinolamine dehydratase
CLM98_11740	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CLM98_11740	COG0316	Belongs to the HesB IscA family
CLM98_11795	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_11880	COG1238	metal cluster binding
CLM98_11915	COG3279	Response regulator of the LytR AlgR family
CLM98_11965	COG4566	intracellular signal transduction
CLM98_11975	COG5001	Diguanylate cyclase
CLM98_11995	COG3685	Protein conserved in bacteria
CLM98_12020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLM98_12020	COG1648	precorrin-2 dehydrogenase activity
CLM98_12035	COG2814	Major facilitator Superfamily
CLM98_12050	COG1335	isochorismatase
CLM98_12065	COG2197	response regulator
CLM98_12085	COG0583	DNA-binding transcription factor activity
CLM98_12090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CLM98_12095	COG3002	Belongs to the UPF0753 family
CLM98_12105	COG1396	sequence-specific DNA binding
CLM98_12110	COG5489	Protein of unknown function (DUF736)
CLM98_12115	COG2003	Belongs to the UPF0758 family
CLM98_12140	COG0582	viral genome integration into host DNA
CLM98_12150	COG4774	siderophore transport
CLM98_12170	COG2336	PFAM SpoVT AbrB
CLM98_12195	COG4206	TonB-dependent receptor
CLM98_12235	COG2274	protein secretion by the type I secretion system
CLM98_12245	COG1192	Involved in chromosome partitioning
CLM98_12290	COG0270	DNA (cytosine-5-)-methyltransferase activity
CLM98_12340	COG4804	nuclease activity
CLM98_12350	COG5006	permease, DMT superfamily
CLM98_12365	COG2249	NAD(P)H dehydrogenase (quinone) activity
CLM98_12375	COG3938	Belongs to the proline racemase family
CLM98_12380	COG0655	NAD(P)H dehydrogenase (quinone) activity
CLM98_12390	COG2807	transmembrane transport
CLM98_12395	COG2207	Transcriptional regulator
CLM98_12545	COG0210	DNA helicase
CLM98_12625	COG2084	Dehydrogenase
CLM98_12645	COG2003	Belongs to the UPF0758 family
CLM98_12680	COG0582	viral genome integration into host DNA
CLM98_12685	COG0519	Catalyzes the synthesis of GMP from XMP
CLM98_12685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CLM98_12695	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CLM98_12705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CLM98_12705	COG0475	glutathione-regulated potassium exporter activity
CLM98_12710	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CLM98_12720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLM98_12725	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CLM98_12735	COG0776	regulation of translation
CLM98_12740	COG0539	negative regulation of cytoplasmic translation
CLM98_12745	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CLM98_12750	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CLM98_12765	COG2957	Belongs to the agmatine deiminase family
CLM98_12770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLM98_12795	COG0395	ABC-type sugar transport system, permease component
CLM98_12800	COG1175	transmembrane transport
CLM98_12830	COG2350	Protein conserved in bacteria
CLM98_12835	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CLM98_12840	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CLM98_12845	COG1187	pseudouridine synthase activity
CLM98_12865	COG0436	Aminotransferase
CLM98_12870	COG4133	protoheme IX ABC transporter activity
CLM98_12890	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CLM98_12895	COG1138	Cytochrome C-type biogenesis protein
CLM98_12915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CLM98_12920	COG1278	Cold shock
CLM98_12925	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CLM98_12930	COG4988	ABC transporter
CLM98_12940	COG1294	oxidase, subunit
CLM98_12970	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CLM98_12975	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CLM98_12985	COG0165	Argininosuccinate lyase
CLM98_12990	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CLM98_13000	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CLM98_13015	COG0137	argininosuccinate synthase activity
CLM98_13020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLM98_13030	COG0215	cysteine-tRNA ligase activity
CLM98_13035	COG2166	iron-sulfur cluster assembly
CLM98_13045	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CLM98_13050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CLM98_13055	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CLM98_13085	COG4302	ethanolamine ammonia-lyase activity
CLM98_13145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CLM98_13150	COG0402	S-adenosylhomocysteine deaminase activity
CLM98_13160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CLM98_13165	COG1509	lysine 2,3-aminomutase activity
CLM98_13170	COG3300	MHYT domain
CLM98_13170	COG5001	Diguanylate cyclase
CLM98_13185	COG0483	inositol monophosphate 1-phosphatase activity
CLM98_13215	COG0513	Belongs to the DEAD box helicase family
CLM98_13220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLM98_13225	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CLM98_13235	COG0625	glutathione transferase activity
CLM98_13245	COG4681	YaeQ
CLM98_13250	COG2081	HI0933 family
CLM98_13260	COG0501	Belongs to the peptidase M48B family
CLM98_13265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLM98_13270	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_13295	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CLM98_13300	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLM98_13305	COG0802	atpase or kinase
CLM98_13310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CLM98_13310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CLM98_13315	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLM98_13320	COG1570	exodeoxyribonuclease VII activity
CLM98_13330	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CLM98_13515	COG0835	chemotaxis
CLM98_13520	COG0840	transmembrane signaling receptor activity
CLM98_13525	COG2094	Belongs to the DNA glycosylase MPG family
CLM98_13530	COG1201	RNA secondary structure unwinding
CLM98_13550	COG2969	positive regulation of protein catabolic process
CLM98_13555	COG0625	glutathione transferase activity
CLM98_13560	COG2857	Cytochrome c1
CLM98_13565	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CLM98_13570	COG0723	plastoquinol--plastocyanin reductase activity
CLM98_13580	COG0741	lytic transglycosylase activity
CLM98_13595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLM98_13600	COG1702	phosphate starvation-inducible protein PhoH
CLM98_13610	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CLM98_13620	COG4535	Mg2 and Co2 transporter CorC
CLM98_13635	COG1012	belongs to the aldehyde dehydrogenase family
CLM98_13640	COG1177	transmembrane transport
CLM98_13645	COG1176	ABC-type spermidine putrescine transport system, permease component I
CLM98_13650	COG3842	ATPase activity
CLM98_13670	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CLM98_13685	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CLM98_13690	COG0174	glutamine synthetase
CLM98_13695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLM98_13700	COG3706	GGDEF domain
CLM98_13700	COG0745	RESPONSE REGULATOR receiver
CLM98_13705	COG2703	oxygen carrier activity
CLM98_13710	COG0477	Major facilitator Superfamily
CLM98_13720	COG0243	molybdopterin cofactor binding
CLM98_13725	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CLM98_13755	COG2733	membrane
CLM98_13760	COG5002	protein histidine kinase activity
CLM98_13760	COG2205	protein histidine kinase activity
CLM98_13760	COG0784	Response regulator, receiver
CLM98_13770	COG0477	Major facilitator Superfamily
CLM98_13780	COG2902	Dehydrogenase
CLM98_13790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLM98_13795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLM98_13800	COG1609	Transcriptional regulator
CLM98_13805	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLM98_13805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLM98_13810	COG1105	Belongs to the carbohydrate kinase PfkB family
CLM98_13815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLM98_13815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLM98_13855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLM98_13865	COG1862	Preprotein translocase
CLM98_13870	COG0343	queuine tRNA-ribosyltransferase activity
CLM98_13875	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CLM98_13910	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CLM98_13915	COG3291	Pkd domain containing protein
CLM98_13920	COG0405	Gamma-glutamyltransferase
CLM98_13925	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLM98_13940	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CLM98_13945	COG0742	ribosomal rna small subunit methyltransferase
CLM98_13950	COG0326	Molecular chaperone. Has ATPase activity
CLM98_14035	COG0531	amino acid
CLM98_14050	COG0006	proline dipeptidase activity
CLM98_14060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLM98_14075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLM98_14080	COG3938	Belongs to the proline racemase family
CLM98_14090	COG0552	protein localization to endoplasmic reticulum
CLM98_14100	COG1194	a g-specific adenine glycosylase
CLM98_14105	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CLM98_14110	COG0784	Response regulator, receiver
CLM98_14110	COG4191	Histidine kinase
CLM98_14125	COG0322	excinuclease ABC activity
CLM98_14140	COG3040	lipid binding
CLM98_14155	COG1960	acyl-CoA dehydrogenase activity
CLM98_14165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLM98_14185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLM98_14190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLM98_14195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLM98_14230	COG0438	transferase activity, transferring glycosyl groups
CLM98_14235	COG0438	transferase activity, transferring glycosyl groups
CLM98_14280	COG0776	regulation of translation
CLM98_14285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLM98_14285	COG0072	phenylalanine-tRNA ligase activity
CLM98_14290	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CLM98_14295	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CLM98_14300	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CLM98_14305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CLM98_14310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLM98_14335	COG1082	Xylose isomerase domain protein TIM barrel
CLM98_14350	COG0366	Alpha amylase catalytic
CLM98_14410	COG3702	type iv secretory pathway
CLM98_14430	COG2948	multi-organism process
CLM98_14450	COG3505	Type IV secretory pathway VirD4
CLM98_14470	COG0556	nucleotide-excision repair
CLM98_14555	COG4695	Portal protein
CLM98_14600	COG3179	chitinase
CLM98_14695	COG3275	phosphorelay sensor kinase activity
CLM98_14700	COG1611	Belongs to the LOG family
CLM98_14715	COG2095	MarC family integral membrane protein
CLM98_14725	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CLM98_14730	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CLM98_14760	COG1185	polyribonucleotide nucleotidyltransferase activity
CLM98_14765	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CLM98_14770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CLM98_14775	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CLM98_14780	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CLM98_14785	COG0195	Participates in both transcription termination and antitermination
CLM98_14790	COG0779	Required for maturation of 30S ribosomal subunits
CLM98_14800	COG1007	ATP synthesis coupled electron transport
CLM98_14815	COG0713	ATP synthesis coupled electron transport
CLM98_14825	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLM98_14830	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CLM98_14840	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CLM98_14845	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CLM98_14850	COG0649	NAD binding
CLM98_14855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLM98_14860	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLM98_14865	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLM98_14880	COG0149	triose-phosphate isomerase activity
CLM98_14885	COG0300	oxidoreductase activity
CLM98_14915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLM98_14920	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CLM98_14925	COG0159	tryptophan synthase activity
CLM98_14935	COG0133	tryptophan synthase activity
CLM98_14945	COG0135	phosphoribosylanthranilate isomerase activity
CLM98_14950	COG0101	tRNA pseudouridine synthase activity
CLM98_14970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CLM98_14975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLM98_14980	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CLM98_14985	COG2890	protein-(glutamine-N5) methyltransferase activity
CLM98_14995	COG0688	phosphatidylethanolamine metabolic process
CLM98_15010	COG0433	COG0433 Predicted ATPase
CLM98_15015	COG0494	nUDIX hydrolase
CLM98_15035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLM98_15040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLM98_15065	COG0717	Belongs to the dCTP deaminase family
CLM98_15075	COG0489	protein tyrosine kinase activity
CLM98_15095	COG3590	peptidase
CLM98_15105	COG3590	peptidase
CLM98_15125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLM98_15130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLM98_15135	COG2311	Membrane
CLM98_15140	COG1047	Peptidyl-prolyl cis-trans
CLM98_15145	COG0791	NLP P60 protein
CLM98_15150	COG0791	NLP P60 protein
CLM98_15160	COG4106	trans-aconitate 2-methyltransferase activity
CLM98_15165	COG1301	dicarboxylic acid transport
CLM98_15170	COG1785	Belongs to the alkaline phosphatase family
CLM98_15180	COG0037	tRNA processing
CLM98_15185	COG1722	exodeoxyribonuclease VII activity
CLM98_15190	COG0142	geranyltranstransferase activity
CLM98_15195	COG4104	PAAR repeat-containing protein
CLM98_15205	COG0312	modulator of DNA gyrase
CLM98_15210	COG3028	Belongs to the UPF0307 family
CLM98_15215	COG0312	modulator of DNA gyrase
CLM98_15225	COG3164	Protein of unknown function
CLM98_15230	COG1530	ribonuclease E activity
CLM98_15235	COG0424	maF-like protein
CLM98_15240	COG2968	Membrane
CLM98_15255	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CLM98_15270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CLM98_15285	COG0495	leucyl-tRNA aminoacylation
CLM98_15295	COG3118	belongs to the thioredoxin family
CLM98_15320	COG2155	Conserved Protein
CLM98_15325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CLM98_15365	COG1132	(ABC) transporter
CLM98_15395	COG1538	Outer membrane efflux protein
CLM98_15400	COG0745	RESPONSE REGULATOR receiver
CLM98_15405	COG5002	protein histidine kinase activity
CLM98_15405	COG5000	phosphorelay sensor kinase activity
CLM98_15410	COG0475	glutathione-regulated potassium exporter activity
CLM98_15415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CLM98_15420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CLM98_15440	COG3706	GGDEF domain
CLM98_15440	COG0745	RESPONSE REGULATOR receiver
CLM98_15445	COG1187	pseudouridine synthase activity
CLM98_15450	COG5002	protein histidine kinase activity
CLM98_15450	COG5001	Diguanylate cyclase
CLM98_15570	COG0667	Aldo Keto reductase
CLM98_15580	COG2814	Major facilitator Superfamily
CLM98_15585	COG0583	DNA-binding transcription factor activity
CLM98_15595	COG2207	Transcriptional regulator
CLM98_15605	COG1309	transcriptional regulator
CLM98_15610	COG1538	Outer membrane efflux protein
CLM98_15630	COG0735	belongs to the Fur family
CLM98_15635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLM98_15660	COG4452	Inner membrane protein CreD
CLM98_15670	COG2205	protein histidine kinase activity
CLM98_15675	COG0745	RESPONSE REGULATOR receiver
CLM98_15680	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CLM98_15690	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLM98_15730	COG2198	Histidine kinase
CLM98_15730	COG0643	Histidine kinase
CLM98_15735	COG0840	transmembrane signaling receptor activity
CLM98_15740	COG0835	chemotaxis
CLM98_15745	COG2200	EAL domain
CLM98_15745	COG2199	diguanylate cyclase activity
CLM98_15745	COG2202	Pas domain
CLM98_15750	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLM98_15755	COG2201	protein-glutamate methylesterase activity
CLM98_15760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLM98_15765	COG3590	peptidase
CLM98_15775	COG0588	phosphoglycerate mutase activity
CLM98_15780	COG1515	deoxyribonuclease V activity
CLM98_15790	COG1741	Belongs to the pirin family
CLM98_15805	COG1741	Belongs to the pirin family
CLM98_15810	COG1966	Carbon starvation protein
CLM98_15815	COG2879	small protein
CLM98_15875	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CLM98_15880	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CLM98_15885	COG2080	2 iron, 2 sulfur cluster binding
CLM98_15895	COG2203	Gaf domain
CLM98_15895	COG3706	GGDEF domain
CLM98_15895	COG4251	negative regulation of phosphorylation
CLM98_15895	COG5001	Diguanylate cyclase
CLM98_15935	COG0629	single-stranded DNA binding
CLM98_15940	COG0142	geranyltranstransferase activity
CLM98_15955	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CLM98_15970	COG0527	aspartate kinase activity
CLM98_15975	COG0384	phenazine biosynthesis protein PhzF
CLM98_15980	COG0384	phenazine biosynthesis protein PhzF
CLM98_15990	COG1764	response to oxidative stress
CLM98_15995	COG0540	Belongs to the ATCase OTCase family
CLM98_16000	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CLM98_16005	COG1678	Uncharacterized ACR, COG1678
CLM98_16015	COG0519	Catalyzes the synthesis of GMP from XMP
CLM98_16025	COG5297	Belongs to the glycosyl hydrolase family 6
CLM98_16040	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CLM98_16055	COG0739	heme binding
CLM98_16075	COG0693	protein deglycase activity
CLM98_16085	COG1959	2 iron, 2 sulfur cluster binding
CLM98_16090	COG0719	Fe-S assembly protein
CLM98_16095	COG0396	ATPase activity
CLM98_16100	COG0719	Fe-S assembly protein
CLM98_16105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CLM98_16120	COG4774	siderophore transport
CLM98_16125	COG3128	pkhd-type hydroxylase
CLM98_16150	COG1477	protein flavinylation
CLM98_16155	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CLM98_16170	COG1555	photosystem II stabilization
CLM98_16175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLM98_16185	COG3178	'Phosphotransferase
CLM98_16190	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CLM98_16200	COG0628	permease
CLM98_16210	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CLM98_16220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CLM98_16240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLM98_16245	COG0271	Belongs to the BolA IbaG family
CLM98_16255	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CLM98_16265	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CLM98_16270	COG1137	ATPase activity
CLM98_16285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLM98_16290	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CLM98_16295	COG1660	Displays ATPase and GTPase activities
CLM98_16305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLM98_16310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLM98_16320	COG2239	Acts as a magnesium transporter
CLM98_16335	COG1294	oxidase, subunit
CLM98_16340	COG1271	oxidase subunit
CLM98_16350	COG1113	amino acid transport
CLM98_16380	COG2197	response regulator
CLM98_16385	COG0531	amino acid
CLM98_16420	COG1234	tRNA 3'-trailer cleavage
CLM98_16460	COG2814	Major facilitator Superfamily
CLM98_16470	COG0754	glutathionylspermidine amidase activity
CLM98_16495	COG1842	Phage shock protein A
CLM98_16505	COG0259	pyridoxamine-phosphate oxidase activity
CLM98_16510	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CLM98_16515	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CLM98_16525	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CLM98_16600	COG2814	Major facilitator Superfamily
CLM98_16620	COG2198	Histidine kinase
CLM98_16620	COG0784	Response regulator, receiver
CLM98_16620	COG2205	protein histidine kinase activity
CLM98_16625	COG2353	YceI-like domain
CLM98_16645	COG1760	l-serine dehydratase
CLM98_16660	COG0527	aspartate kinase activity
CLM98_16660	COG0460	homoserine dehydrogenase
CLM98_16665	COG0626	cystathionine gamma-synthase activity
CLM98_16670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CLM98_16675	COG0739	heme binding
CLM98_16680	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CLM98_16685	COG1272	protein, Hemolysin III
CLM98_16690	COG2982	Protein involved in outer membrane biogenesis
CLM98_16695	COG0516	GMP reductase activity
CLM98_16695	COG0517	IMP dehydrogenase activity
CLM98_16700	COG0463	Glycosyl transferase, family 2
CLM98_16705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CLM98_16710	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CLM98_16720	COG4771	TonB-dependent receptor
CLM98_16730	COG1309	transcriptional regulator
CLM98_16735	COG2267	carboxylic ester hydrolase activity
CLM98_16740	COG1960	acyl-CoA dehydrogenase activity
CLM98_16765	COG0509	glycine decarboxylation via glycine cleavage system
CLM98_16770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CLM98_16785	COG1742	UPF0060 membrane protein
CLM98_16790	COG3956	TIGRFAM MazG family protein
CLM98_16800	COG0494	nUDIX hydrolase
CLM98_16810	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CLM98_16815	COG0837	glucose binding
CLM98_16830	COG1388	LysM domain
CLM98_16830	COG3858	chitin binding
CLM98_16845	COG1472	Belongs to the glycosyl hydrolase 3 family
CLM98_16860	COG0531	amino acid
CLM98_16870	COG1486	melibiose metabolic process
CLM98_16880	COG3537	Alpha-1,2-mannosidase
CLM98_16920	COG3142	Participates in the control of copper homeostasis
CLM98_16925	COG1446	asparaginase
CLM98_16965	COG0840	transmembrane signaling receptor activity
CLM98_16985	COG0189	ligase activity
CLM98_16995	COG1397	ADP-ribosylglycohydrolase
CLM98_17005	COG1199	ATP-dependent helicase activity
CLM98_17015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CLM98_17020	COG1215	transferase activity, transferring glycosyl groups
CLM98_17040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLM98_17050	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CLM98_17055	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CLM98_17060	COG0535	radical SAM domain protein
CLM98_17065	COG0535	radical SAM domain protein
CLM98_17080	COG0837	glucose binding
CLM98_17095	COG1643	Atp-dependent helicase
CLM98_17100	COG0783	Belongs to the Dps family
CLM98_17110	COG0514	ATP-dependent DNA helicase (RecQ)
CLM98_17145	COG0840	transmembrane signaling receptor activity
CLM98_17165	COG3920	Histidine kinase
CLM98_17170	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CLM98_17180	COG0602	queuosine metabolic process
CLM98_17190	COG2885	chlorophyll binding
CLM98_17195	COG0823	Involved in the tonB-independent uptake of proteins
CLM98_17205	COG0848	biopolymer transport protein
CLM98_17215	COG0824	Thioesterase
CLM98_17220	COG2255	four-way junction helicase activity
CLM98_17230	COG3158	transport of potassium into the cell
CLM98_17235	COG0632	four-way junction helicase activity
CLM98_17240	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CLM98_17245	COG0217	transcriptional regulatory protein
CLM98_17260	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLM98_17275	COG0477	Major facilitator Superfamily
CLM98_17320	COG0488	(ABC) transporter
CLM98_17360	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CLM98_17360	COG4651	solute:proton antiporter activity
CLM98_17385	COG4772	TonB-dependent receptor
CLM98_17395	COG4264	IucA IucC family
CLM98_17410	COG0019	diaminopimelate decarboxylase activity
CLM98_17435	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CLM98_17445	COG1492	cobalamin metabolic process
CLM98_17455	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CLM98_17475	COG4206	TonB-dependent receptor
CLM98_17480	COG0542	response to heat
CLM98_17485	COG1116	anion transmembrane transporter activity
CLM98_17490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLM98_17495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CLM98_17500	COG0667	Aldo Keto reductase
CLM98_17510	COG4771	TonB-dependent receptor
CLM98_17515	COG2827	Endonuclease containing a URI domain
CLM98_17555	COG1877	trehalose-phosphatase activity
CLM98_17560	COG3387	PFAM Glycoside hydrolase 15-related
CLM98_17580	COG0840	transmembrane signaling receptor activity
CLM98_17585	COG3011	Protein conserved in bacteria
CLM98_17600	COG0564	pseudouridine synthase activity
CLM98_17605	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLM98_17615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLM98_17615	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLM98_17660	COG2369	cell adhesion
CLM98_17685	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CLM98_17690	COG0045	succinate-CoA ligase (ADP-forming) activity
CLM98_17705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CLM98_17740	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CLM98_17745	COG0237	dephospho-CoA kinase activity
CLM98_17775	COG5002	protein histidine kinase activity
CLM98_17780	COG0745	RESPONSE REGULATOR receiver
CLM98_17865	COG2003	Belongs to the UPF0758 family
CLM98_17890	COG4191	Histidine kinase
CLM98_17890	COG0784	Response regulator, receiver
CLM98_17895	COG4191	Histidine kinase
CLM98_17895	COG0784	Response regulator, receiver
CLM98_18015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CLM98_18045	COG2022	thiamine diphosphate biosynthetic process
CLM98_18055	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CLM98_18060	COG3273	potassium ion transport
CLM98_18060	COG0471	metal ion transport
CLM98_18085	COG1970	mechanosensitive ion channel activity
CLM98_18105	COG3250	beta-galactosidase activity
CLM98_18110	COG4948	Mandelate Racemase Muconate Lactonizing
CLM98_18125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLM98_18135	COG0308	aminopeptidase N
CLM98_18200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLM98_18210	COG2895	sulfate adenylyltransferase (ATP) activity
CLM98_18210	COG0529	Catalyzes the synthesis of activated sulfate
CLM98_18215	COG0175	sulfate reduction
CLM98_18220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CLM98_18225	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLM98_18230	COG0175	sulfate reduction
CLM98_18270	COG1648	precorrin-2 dehydrogenase activity
CLM98_18270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLM98_18285	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CLM98_18290	COG3588	fructose-bisphosphate aldolase
CLM98_18305	COG0469	pyruvate kinase activity
CLM98_18315	COG0126	phosphoglycerate kinase activity
CLM98_18340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CLM98_18350	COG3047	cAMP biosynthetic process
CLM98_18355	COG3047	cAMP biosynthetic process
CLM98_18365	COG3453	Protein conserved in bacteria
CLM98_18365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLM98_18370	COG0725	ABC transporter, periplasmic molybdate-binding protein
CLM98_18375	COG4149	molybdate abc transporter
CLM98_18380	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CLM98_18415	COG1376	ErfK ybiS ycfS ynhG family protein
CLM98_18420	COG0739	heme binding
CLM98_18430	COG4773	Receptor
CLM98_18435	COG0596	Alpha beta hydrolase
CLM98_18440	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CLM98_18445	COG1301	dicarboxylic acid transport
CLM98_18460	COG2304	oxidoreductase activity
CLM98_18480	COG0714	Associated with various cellular activities
CLM98_18515	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CLM98_18530	COG0254	rRNA binding
CLM98_18540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CLM98_18550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLM98_18555	COG1758	RNA polymerase activity
CLM98_18560	COG0194	GDP metabolic process
CLM98_18565	COG1561	YicC-like family, N-terminal region
CLM98_18570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CLM98_18580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CLM98_18585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLM98_18600	COG0006	proline dipeptidase activity
CLM98_18610	COG0006	proline dipeptidase activity
CLM98_18615	COG3079	Belongs to the UPF0149 family
CLM98_18635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CLM98_18645	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CLM98_18655	COG2912	Transglutaminase-like superfamily
CLM98_18660	COG1773	rubredoxin
CLM98_18665	COG0352	thiamine-phosphate diphosphorylase activity
CLM98_18680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CLM98_18695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLM98_18725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CLM98_18730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLM98_18740	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_18750	COG0671	phosphoesterase, PA-phosphatase related
CLM98_18755	COG3781	membrane
CLM98_18765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLM98_18770	COG0563	adenylate kinase activity
CLM98_18785	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CLM98_18795	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CLM98_18815	COG3710	Transcriptional regulator
CLM98_18820	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CLM98_18835	COG0840	transmembrane signaling receptor activity
CLM98_18840	COG0405	Gamma-glutamyltransferase
CLM98_18845	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CLM98_18865	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLM98_18870	COG0473	3-isopropylmalate dehydrogenase activity
CLM98_18875	COG0066	3-isopropylmalate dehydratase activity
CLM98_18880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLM98_18900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CLM98_18905	COG1538	Outer membrane efflux protein
CLM98_18910	COG1519	Transferase
CLM98_18920	COG1560	Kdo2-lipid A biosynthetic process
CLM98_18945	COG0280	phosphate acetyltransferase
CLM98_18945	COG0281	malic enzyme
CLM98_18950	COG1301	dicarboxylic acid transport
CLM98_18980	COG0583	DNA-binding transcription factor activity
CLM98_18990	COG0667	Aldo Keto reductase
CLM98_19005	COG2197	response regulator
CLM98_19010	COG1840	ABC-type Fe3 transport system, periplasmic component
CLM98_19015	COG0642	Histidine kinase
CLM98_19035	COG2851	Citrate transporter
CLM98_19040	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_19045	COG1609	Transcriptional regulator
CLM98_19050	COG2211	Major facilitator Superfamily
CLM98_19075	COG1162	GTPase activity
CLM98_19105	COG4773	Receptor
CLM98_19110	COG0726	polysaccharide deacetylase
CLM98_19115	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CLM98_19155	COG1307	EDD domain protein, DegV family
CLM98_19160	COG0242	peptide deformylase activity
CLM98_19190	COG0457	Tetratricopeptide repeat
CLM98_19195	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CLM98_19200	COG1215	transferase activity, transferring glycosyl groups
CLM98_19205	COG1215	transferase activity, transferring glycosyl groups
CLM98_19220	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CLM98_19275	COG2188	Transcriptional regulator
CLM98_19285	COG1450	Type ii and iii secretion system protein
CLM98_19300	COG3166	PFAM Fimbrial assembly family protein
CLM98_19305	COG3156	type II secretion system protein K
CLM98_19310	COG4795	General secretion pathway protein
CLM98_19315	COG2165	general secretion pathway protein
CLM98_19320	COG4970	Tfp pilus assembly protein FimT
CLM98_19325	COG2165	general secretion pathway protein
CLM98_19330	COG1459	type II secretion system
CLM98_19340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CLM98_19345	COG1404	Belongs to the peptidase S8 family
CLM98_19350	COG5295	Hep Hag repeat protein
CLM98_19355	COG1404	Belongs to the peptidase S8 family
CLM98_19360	COG5295	Hep Hag repeat protein
CLM98_19370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLM98_19370	COG0047	phosphoribosylformylglycinamidine synthase activity
CLM98_19385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CLM98_19400	COG4974	Belongs to the 'phage' integrase family
CLM98_19415	COG0795	lipopolysaccharide-transporting ATPase activity
CLM98_19425	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CLM98_19440	COG0525	valine-tRNA ligase activity
CLM98_19470	COG1183	phosphatidylcholine synthase activity
CLM98_19480	COG0442	prolyl-tRNA aminoacylation
CLM98_19495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CLM98_19500	COG1127	ABC transporter
CLM98_19505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CLM98_19505	COG3218	ABC-type transport auxiliary lipoprotein component
CLM98_19540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLM98_19545	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CLM98_19545	COG0662	Cupin 2, conserved barrel domain protein
CLM98_19580	COG2086	electron transfer activity
CLM98_19595	COG0546	phosphoglycolate phosphatase activity
CLM98_19595	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CLM98_19600	COG0277	FAD linked oxidase domain protein
CLM98_19615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLM98_19645	COG0438	transferase activity, transferring glycosyl groups
CLM98_19645	COG1216	Glycosyl transferase, family 2
CLM98_19665	COG0626	cystathionine gamma-synthase activity
CLM98_19700	COG0625	glutathione transferase activity
CLM98_19715	COG0513	Belongs to the DEAD box helicase family
CLM98_19725	COG4206	TonB-dependent receptor
CLM98_19735	COG0720	synthase
CLM98_19745	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CLM98_19750	COG1956	GAF domain-containing protein
CLM98_19760	COG2819	hydrolase of the alpha beta superfamily
CLM98_19775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLM98_19780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLM98_19795	COG0339	signal peptide processing
CLM98_19810	COG2132	Multicopper oxidase
CLM98_19850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CLM98_19855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLM98_19860	COG1136	(ABC) transporter
CLM98_19860	COG4591	ABC-type transport system involved in lipoprotein release permease component
CLM98_19865	COG0577	efflux transmembrane transporter activity
CLM98_19865	COG1136	(ABC) transporter
CLM98_19870	COG0577	efflux transmembrane transporter activity
CLM98_19885	COG4191	Histidine kinase
CLM98_19890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CLM98_19905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CLM98_19910	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CLM98_19915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLM98_19920	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CLM98_19925	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLM98_19930	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CLM98_19940	COG0356	it plays a direct role in the translocation of protons across the membrane
CLM98_19960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLM98_19970	COG0508	dehydrogenase complex catalyzes the overall conversion of
CLM98_20010	COG2011	ABC-type metal ion transport system permease component
CLM98_20015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLM98_20020	COG0697	spore germination
CLM98_20025	COG1666	GTP binding
CLM98_20035	COG0784	Response regulator, receiver
CLM98_20035	COG5002	protein histidine kinase activity
CLM98_20035	COG2198	Histidine kinase
CLM98_20055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLM98_20060	COG1187	pseudouridine synthase activity
CLM98_20065	COG2813	Specifically methylates the guanine in position
CLM98_20085	COG2205	protein histidine kinase activity
CLM98_20085	COG2202	Pas domain
CLM98_20105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CLM98_20110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLM98_20115	COG1522	sequence-specific DNA binding
CLM98_20170	COG0842	Transport permease protein
CLM98_20175	COG1131	(ABC) transporter
CLM98_20180	COG0025	NhaP-type Na H and K H
CLM98_20190	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CLM98_20195	COG1573	uracil-dna glycosylase
CLM98_20205	COG3384	dioxygenase
CLM98_20215	COG0583	DNA-binding transcription factor activity
CLM98_20225	COG0667	Aldo Keto reductase
CLM98_20260	COG0531	amino acid
CLM98_20275	COG2972	Histidine kinase
CLM98_20300	COG3685	Protein conserved in bacteria
CLM98_20305	COG3546	catalase activity
CLM98_20355	COG1271	oxidase subunit
CLM98_20360	COG1294	oxidase, subunit
CLM98_20375	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_20380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CLM98_20400	COG1132	(ABC) transporter
CLM98_20415	COG1063	alcohol dehydrogenase
CLM98_20490	COG0251	oxidation-reduction process
CLM98_20515	COG0840	transmembrane signaling receptor activity
CLM98_20535	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CLM98_20580	COG0024	Methionine aminopeptidase
CLM98_20610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLM98_20615	COG1490	D-aminoacyl-tRNA deacylase activity
CLM98_20620	COG1560	Kdo2-lipid A biosynthetic process
CLM98_20675	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLM98_20675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLM98_20680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLM98_20685	COG0242	peptide deformylase activity
CLM98_20690	COG1652	LysM domain
CLM98_20695	COG0758	DNA mediated transformation
CLM98_20700	COG2922	Belongs to the Smg family
CLM98_20715	COG1754	DNA topoisomerase type I activity
CLM98_20715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLM98_20720	COG0009	L-threonylcarbamoyladenylate synthase
CLM98_20735	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_20745	COG0616	signal peptide processing
CLM98_20750	COG0534	Mate efflux family protein
CLM98_20770	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CLM98_20775	COG0625	glutathione transferase activity
CLM98_20790	COG1252	NADH dehydrogenase
CLM98_20795	COG2860	membrane
CLM98_20800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLM98_20805	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CLM98_20810	COG3437	response regulator, receiver
CLM98_20815	COG2177	Part of the ABC transporter FtsEX involved in
CLM98_20820	COG2884	Cell division ATP-binding protein ftsE
CLM98_20825	COG0513	Belongs to the DEAD box helicase family
CLM98_20830	COG3118	belongs to the thioredoxin family
CLM98_20835	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CLM98_20850	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CLM98_20855	COG0583	DNA-binding transcription factor activity
CLM98_20900	COG1518	maintenance of DNA repeat elements
CLM98_20905	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CLM98_20915	COG1652	LysM domain
CLM98_20920	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CLM98_20920	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CLM98_20925	COG1473	amidohydrolase
CLM98_20930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLM98_20935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLM98_20945	COG5383	Protein conserved in bacteria
CLM98_20995	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CLM98_21000	COG3023	N-Acetylmuramoyl-L-alanine amidase
CLM98_21010	COG4948	Mandelate Racemase Muconate Lactonizing
CLM98_21020	COG0531	amino acid
CLM98_21035	COG4682	membrane
CLM98_21040	COG2133	pyrroloquinoline quinone binding
CLM98_21050	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CLM98_21055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CLM98_21060	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CLM98_21065	COG1610	YqeY-like protein
CLM98_21075	COG1295	ribonuclease BN
CLM98_21080	COG0358	DNA primase activity
CLM98_21095	COG0109	protoheme IX farnesyltransferase activity
CLM98_21125	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CLM98_21140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CLM98_21185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CLM98_21190	COG0739	heme binding
CLM98_21195	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CLM98_21205	COG2211	Major facilitator Superfamily
CLM98_21210	COG0708	Exodeoxyribonuclease III
CLM98_21215	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CLM98_21225	COG1192	Involved in chromosome partitioning
CLM98_21230	COG1475	DNA binding
CLM98_21250	COG0463	Glycosyl transferase, family 2
CLM98_21270	COG0756	dUTP diphosphatase activity
CLM98_21275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CLM98_21280	COG2003	Belongs to the UPF0758 family
CLM98_21285	COG0018	arginyl-trna synthetase
CLM98_21300	COG4221	oxidoreductase activity
CLM98_21305	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CLM98_21305	COG2755	lipolytic protein G-D-S-L family
CLM98_21315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLM98_21320	COG1166	arginine decarboxylase activity
CLM98_21325	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CLM98_21365	COG0606	chelatase, subunit chli
CLM98_21380	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CLM98_21420	COG1690	Belongs to the RtcB family
CLM98_21455	COG1090	epimerase
CLM98_21460	COG0745	RESPONSE REGULATOR receiver
CLM98_21465	COG0642	Histidine kinase
CLM98_21495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLM98_21520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLM98_21525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CLM98_21540	COG0753	catalase activity
CLM98_21555	COG2197	response regulator
CLM98_21560	COG4585	Histidine kinase
CLM98_21565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLM98_21570	COG1136	(ABC) transporter
CLM98_21595	COG0697	spore germination
CLM98_21615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLM98_21620	COG0180	Tryptophanyl-tRNA synthetase
CLM98_21625	COG3237	CsbD-like
CLM98_21670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CLM98_21685	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CLM98_21720	COG2205	protein histidine kinase activity
CLM98_21725	COG0745	RESPONSE REGULATOR receiver
CLM98_21735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLM98_21765	COG1199	ATP-dependent helicase activity
CLM98_21780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLM98_21845	COG0625	glutathione transferase activity
CLM98_21885	COG4555	ABC transporter
CLM98_21895	COG1476	TRANSCRIPTIONal
CLM98_21940	COG0543	2 iron, 2 sulfur cluster binding
CLM98_21940	COG0633	Ferredoxin
CLM98_21945	COG1131	(ABC) transporter
CLM98_21950	COG0842	Transport permease protein
CLM98_21960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CLM98_21995	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLM98_22005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLM98_22025	COG0045	succinate-CoA ligase (ADP-forming) activity
CLM98_22025	COG1042	CoA-binding domain protein
CLM98_22025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLM98_22030	COG2239	Acts as a magnesium transporter
CLM98_22050	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CLM98_22055	COG3387	PFAM Glycoside hydrolase 15-related
CLM98_22070	COG3100	YcgL domain-containing protein
CLM98_22075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLM98_22085	COG0463	Glycosyl transferase, family 2
CLM98_22105	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_22140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLM98_22155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLM98_22185	COG1506	peptidase
CLM98_22185	COG4946	Tricorn protease homolog
CLM98_22185	COG0823	Involved in the tonB-independent uptake of proteins
CLM98_22205	COG0408	coproporphyrinogen oxidase activity
CLM98_22245	COG0515	serine threonine protein kinase
CLM98_22245	COG2815	serine threonine protein kinase
CLM98_22250	COG0631	protein serine/threonine phosphatase activity
CLM98_22285	COG3501	Rhs element vgr protein
CLM98_22420	COG0210	DNA helicase
CLM98_22435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLM98_22440	COG0583	DNA-binding transcription factor activity
CLM98_22445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CLM98_22460	COG2159	amidohydrolase
CLM98_22465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CLM98_22470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CLM98_22480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLM98_22500	COG0357	Ribosomal RNA small subunit methyltransferase G
CLM98_22505	COG3540	Alkaline phosphatase
CLM98_22515	COG2091	lysine biosynthetic process via aminoadipic acid
CLM98_22530	COG0708	Exodeoxyribonuclease III
CLM98_22535	COG1940	carbohydrate kinase activity
CLM98_22535	COG1846	Transcriptional regulator
CLM98_22545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLM98_22555	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLM98_22560	COG3162	membrane
CLM98_22570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CLM98_22600	COG3507	Belongs to the glycosyl hydrolase 43 family
CLM98_22620	COG1028	Short-chain dehydrogenase reductase Sdr
CLM98_22625	COG0179	Fumarylacetoacetate (FAA) hydrolase
CLM98_22635	COG4948	Mandelate Racemase Muconate Lactonizing
CLM98_22645	COG3254	rhamnose metabolic process
CLM98_22650	COG0738	Major facilitator superfamily
CLM98_22655	COG1414	Transcriptional regulator
CLM98_22660	COG1971	Probably functions as a manganese efflux pump
CLM98_22665	COG2205	protein histidine kinase activity
CLM98_22680	COG3459	Glycosyltransferase 36 associated
CLM98_22685	COG2211	Major facilitator Superfamily
CLM98_22690	COG3265	gluconokinase activity
CLM98_22700	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLM98_22720	COG2911	Protein conserved in bacteria
CLM98_22725	COG0729	surface antigen
CLM98_22755	COG0752	glycyl-tRNA synthetase alpha subunit
CLM98_22760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CLM98_22775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CLM98_22775	COG0519	Catalyzes the synthesis of GMP from XMP
CLM98_22785	COG0805	protein transport
CLM98_22790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CLM98_22795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CLM98_22805	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CLM98_22830	COG2974	May be involved in recombination
CLM98_22835	COG0037	tRNA processing
CLM98_22845	COG2115	Belongs to the xylose isomerase family
CLM98_22855	COG3661	Belongs to the glycosyl hydrolase 67 family
CLM98_22865	COG4948	Mandelate Racemase Muconate Lactonizing
CLM98_22875	COG1472	Belongs to the glycosyl hydrolase 3 family
CLM98_22880	COG0246	Mannitol dehydrogenase
CLM98_22960	COG3386	PFAM SMP-30 Gluconolaconase
CLM98_22970	COG3250	beta-galactosidase activity
CLM98_22975	COG1904	glucuronate isomerase
CLM98_22990	COG3693	PFAM glycoside hydrolase, family 10
CLM98_23005	COG2211	Major facilitator Superfamily
CLM98_23070	COG2937	Belongs to the GPAT DAPAT family
CLM98_23105	COG0284	orotidine-5'-phosphate decarboxylase activity
CLM98_23110	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CLM98_23120	COG3132	Protein of unknown function, DUF480
CLM98_23135	COG0210	DNA helicase
CLM98_23140	COG1435	thymidine kinase activity
CLM98_23150	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CLM98_23160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CLM98_23210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLM98_23300	COG1199	ATP-dependent helicase activity
CLM98_23310	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CLM98_23320	COG0745	RESPONSE REGULATOR receiver
CLM98_23400	COG1525	nuclease
CLM98_23455	COG1475	DNA binding
CLM98_23490	COG0629	single-stranded DNA binding
CLM98_23550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CLM98_23650	COG4232	protein-disulfide reductase activity
CLM98_23745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLM98_23750	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLM98_23765	COG0010	Belongs to the arginase family
CLM98_23820	COG2132	Multicopper oxidase
CLM98_23850	COG0653	protein targeting
CLM98_23875	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLM98_23900	COG0431	NADPH-dependent FMN reductase
CLM98_23905	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CLM98_23950	COG4644	lycopene metabolic process
CLM98_23975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLM98_24455	COG3504	Conjugal transfer protein
CLM98_24460	COG2948	multi-organism process
CLM98_24625	COG3318	Belongs to the UPF0149 family
CLM98_24625	COG3012	SEC-C Motif Domain Protein
CLM98_24655	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CLM98_24700	COG2951	lytic endotransglycosylase activity
CLM98_24705	COG4644	lycopene metabolic process
CLM98_24835	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CLM98_24860	COG1192	Involved in chromosome partitioning
CLM98_24880	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CLM98_24900	COG0653	protein targeting