locus-tag	class	description
J165_00005	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J165_00012	COG3505	Type IV secretory pathway VirD4
J165_00015	COG1487	ribonuclease activity
J165_00017	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J165_00024	COG2963	transposase activity
J165_00025	COG2801	Transposase and inactivated derivatives
J165_00036	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J165_00040	COG3318	Belongs to the UPF0149 family
J165_00040	COG3012	SEC-C Motif Domain Protein
J165_00043	COG2801	Transposase and inactivated derivatives
J165_00045	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J165_00046	COG4456	Virulence-associated protein
J165_00071	COG1674	ftsk spoiiie
J165_00079	COG3318	Belongs to the UPF0149 family
J165_00079	COG3012	SEC-C Motif Domain Protein
J165_00083	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J165_00085	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J165_00087	COG0187	DNA topoisomerase II activity
J165_00089	COG0501	Belongs to the peptidase M48B family
J165_00095	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
J165_00097	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J165_00106	COG0793	Belongs to the peptidase S41A family
J165_00107	COG4942	peptidase
J165_00109	COG2234	aminopeptidase activity
J165_00111	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J165_00112	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J165_00120	COG2211	Major facilitator Superfamily
J165_00123	COG3693	PFAM glycoside hydrolase, family 10
J165_00125	COG3693	PFAM glycoside hydrolase, family 10
J165_00126	COG1904	glucuronate isomerase
J165_00127	COG3250	beta-galactosidase activity
J165_00129	COG3386	PFAM SMP-30 Gluconolaconase
J165_00134	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J165_00142	COG0246	Mannitol dehydrogenase
J165_00143	COG1472	Belongs to the glycosyl hydrolase 3 family
J165_00145	COG4948	Mandelate Racemase Muconate Lactonizing
J165_00147	COG3661	Belongs to the glycosyl hydrolase 67 family
J165_00149	COG2115	Belongs to the xylose isomerase family
J165_00150	COG0037	tRNA processing
J165_00151	COG2974	May be involved in recombination
J165_00154	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J165_00156	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J165_00157	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J165_00158	COG0805	protein transport
J165_00160	COG0519	Catalyzes the synthesis of GMP from XMP
J165_00160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J165_00162	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J165_00163	COG0752	glycyl-tRNA synthetase alpha subunit
J165_00165	COG0457	Tetratricopeptide repeat
J165_00170	COG4771	TonB-dependent receptor
J165_00171	COG0729	surface antigen
J165_00172	COG2911	Protein conserved in bacteria
J165_00176	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J165_00178	COG3265	gluconokinase activity
J165_00179	COG2211	Major facilitator Superfamily
J165_00180	COG3459	Glycosyltransferase 36 associated
J165_00182	COG2205	protein histidine kinase activity
J165_00183	COG1971	Probably functions as a manganese efflux pump
J165_00184	COG1414	Transcriptional regulator
J165_00185	COG0738	Major facilitator superfamily
J165_00186	COG3254	rhamnose metabolic process
J165_00188	COG4948	Mandelate Racemase Muconate Lactonizing
J165_00189	COG0179	Fumarylacetoacetate (FAA) hydrolase
J165_00190	COG1028	Short-chain dehydrogenase reductase Sdr
J165_00193	COG3507	Belongs to the glycosyl hydrolase 43 family
J165_00199	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J165_00201	COG3162	membrane
J165_00202	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J165_00204	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J165_00206	COG1846	Transcriptional regulator
J165_00206	COG1940	carbohydrate kinase activity
J165_00208	COG0708	Exodeoxyribonuclease III
J165_00211	COG2091	lysine biosynthetic process via aminoadipic acid
J165_00214	COG3540	Alkaline phosphatase
J165_00215	COG0357	Ribosomal RNA small subunit methyltransferase G
J165_00219	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J165_00221	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J165_00222	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J165_00223	COG2159	amidohydrolase
J165_00225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J165_00226	COG0583	DNA-binding transcription factor activity
J165_00227	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J165_00229	COG0210	DNA helicase
J165_00255	COG3501	Rhs element vgr protein
J165_00262	COG0631	protein serine/threonine phosphatase activity
J165_00263	COG2815	serine threonine protein kinase
J165_00263	COG0515	serine threonine protein kinase
J165_00270	COG0408	coproporphyrinogen oxidase activity
J165_00273	COG1506	peptidase
J165_00273	COG4946	Tricorn protease homolog
J165_00273	COG0823	Involved in the tonB-independent uptake of proteins
J165_00278	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J165_00281	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J165_00288	COG1028	Short-chain dehydrogenase reductase Sdr
J165_00291	COG0463	Glycosyl transferase, family 2
J165_00293	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J165_00294	COG3100	YcgL domain-containing protein
J165_00297	COG3387	PFAM Glycoside hydrolase 15-related
J165_00298	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J165_00300	COG3338	carbonate dehydratase activity
J165_00301	COG2239	Acts as a magnesium transporter
J165_00302	COG0045	succinate-CoA ligase (ADP-forming) activity
J165_00302	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J165_00302	COG1042	CoA-binding domain protein
J165_00304	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J165_00305	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J165_00311	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
J165_00314	COG0842	Transport permease protein
J165_00315	COG1131	(ABC) transporter
J165_00316	COG0543	2 iron, 2 sulfur cluster binding
J165_00316	COG0633	Ferredoxin
J165_00325	COG1476	TRANSCRIPTIONal
J165_00327	COG4555	ABC transporter
J165_00334	COG0625	glutathione transferase activity
J165_00345	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J165_00348	COG1199	ATP-dependent helicase activity
J165_00352	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J165_00354	COG0745	RESPONSE REGULATOR receiver
J165_00355	COG2205	protein histidine kinase activity
J165_00360	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J165_00360	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J165_00361	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
J165_00364	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J165_00372	COG3237	CsbD-like
J165_00373	COG0180	Tryptophanyl-tRNA synthetase
J165_00374	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J165_00377	COG0697	spore germination
J165_00382	COG1136	(ABC) transporter
J165_00383	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J165_00384	COG4585	Histidine kinase
J165_00385	COG2197	response regulator
J165_00388	COG0753	catalase activity
J165_00391	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J165_00392	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J165_00397	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J165_00401	COG0642	Histidine kinase
J165_00402	COG0745	RESPONSE REGULATOR receiver
J165_00403	COG1090	epimerase
J165_00411	COG1690	Belongs to the RtcB family
J165_00420	COG4943	cyclic-guanylate-specific phosphodiesterase activity
J165_00423	COG0606	chelatase, subunit chli
J165_00430	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
J165_00431	COG1166	arginine decarboxylase activity
J165_00432	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J165_00434	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J165_00434	COG2755	lipolytic protein G-D-S-L family
J165_00435	COG4221	oxidoreductase activity
J165_00438	COG0018	arginyl-trna synthetase
J165_00439	COG2003	Belongs to the UPF0758 family
J165_00440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J165_00441	COG0756	dUTP diphosphatase activity
J165_00445	COG0463	Glycosyl transferase, family 2
J165_00448	COG1475	DNA binding
J165_00449	COG1192	Involved in chromosome partitioning
J165_00451	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J165_00452	COG0708	Exodeoxyribonuclease III
J165_00453	COG2223	nitrite transmembrane transporter activity
J165_00455	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
J165_00456	COG0739	heme binding
J165_00457	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J165_00464	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J165_00466	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
J165_00468	COG1435	thymidine kinase activity
J165_00469	COG0210	DNA helicase
J165_00472	COG3132	Protein of unknown function, DUF480
J165_00474	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
J165_00475	COG0284	orotidine-5'-phosphate decarboxylase activity
J165_00481	COG2937	Belongs to the GPAT DAPAT family
J165_00488	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J165_00489	COG1064	alcohol dehydrogenase
J165_00490	COG0493	'glutamate synthase
J165_00491	COG0069	glutamate synthase activity
J165_00491	COG0070	glutamate synthase
J165_00491	COG0067	glutamate synthase
J165_00495	COG2366	antibiotic biosynthetic process
J165_00500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J165_00503	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
J165_00504	COG0297	glycogen (starch) synthase activity
J165_00504	COG0438	transferase activity, transferring glycosyl groups
J165_00510	COG0367	asparagine synthase
J165_00516	COG1132	(ABC) transporter
J165_00540	COG1205	dead DEAH box helicase
J165_00540	COG1111	helicase
J165_00541	COG1272	protein, Hemolysin III
J165_00544	COG0300	oxidoreductase activity
J165_00545	COG1028	Short-chain dehydrogenase reductase Sdr
J165_00550	COG2249	NAD(P)H dehydrogenase (quinone) activity
J165_00552	COG2963	transposase activity
J165_00553	COG2801	Transposase and inactivated derivatives
J165_00561	COG3237	CsbD-like
J165_00570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J165_00571	COG0477	Major facilitator Superfamily
J165_00579	COG0714	Associated with various cellular activities
J165_00585	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
J165_00587	COG4772	TonB-dependent receptor
J165_00589	COG0662	Cupin 2, conserved barrel domain protein
J165_00590	COG1012	belongs to the aldehyde dehydrogenase family
J165_00595	COG1304	FMN binding
J165_00597	COG4585	Histidine kinase
J165_00598	COG2197	response regulator
J165_00602	COG3710	Transcriptional regulator
J165_00603	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J165_00617	COG2963	transposase activity
J165_00619	COG0366	Alpha amylase catalytic
J165_00620	COG0366	Alpha amylase catalytic
J165_00621	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J165_00625	COG0657	acetylesterase activity
J165_00625	COG2755	lipolytic protein G-D-S-L family
J165_00627	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J165_00630	COG3507	Belongs to the glycosyl hydrolase 43 family
J165_00631	COG1609	Transcriptional regulator
J165_00632	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
J165_00633	COG1028	Short-chain dehydrogenase reductase Sdr
J165_00635	COG2755	lipolytic protein G-D-S-L family
J165_00639	COG3186	Phenylalanine-4-hydroxylase
J165_00640	COG1522	sequence-specific DNA binding
J165_00642	COG1752	Esterase of the alpha-beta hydrolase superfamily
J165_00644	COG1119	ATPase activity
J165_00647	COG1125	glycine betaine transport
J165_00650	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J165_00653	COG1396	sequence-specific DNA binding
J165_00657	COG0489	protein tyrosine kinase activity
J165_00658	COG2062	phosphohistidine phosphatase, SixA
J165_00660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J165_00669	COG1968	undecaprenyl-diphosphatase activity
J165_00670	COG0174	glutamine synthetase
J165_00671	COG0347	Belongs to the P(II) protein family
J165_00672	COG0004	ammonium transporteR
J165_00673	COG3852	Histidine kinase
J165_00674	COG2204	response regulator
J165_00675	COG2032	superoxide dismutase activity
J165_00676	COG2032	superoxide dismutase activity
J165_00679	COG0183	Belongs to the thiolase family
J165_00686	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J165_00687	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
J165_00688	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J165_00690	COG0028	Belongs to the TPP enzyme family
J165_00691	COG2205	protein histidine kinase activity
J165_00696	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J165_00699	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J165_00700	COG3177	Filamentation induced by cAMP protein fic
J165_00702	COG0596	Alpha beta hydrolase
J165_00704	COG0318	PFAM AMP-dependent synthetase and ligase
J165_00706	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J165_00708	COG1181	Belongs to the D-alanine--D-alanine ligase family
J165_00710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J165_00712	COG0564	pseudouridine synthase activity
J165_00717	COG0339	signal peptide processing
J165_00722	COG0475	glutathione-regulated potassium exporter activity
J165_00723	COG0583	DNA-binding transcription factor activity
J165_00724	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J165_00725	COG2224	Isocitrate lyase
J165_00726	COG3706	GGDEF domain
J165_00732	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J165_00733	COG1960	acyl-CoA dehydrogenase activity
J165_00744	COG0523	cobalamin synthesis protein
J165_00746	COG0697	spore germination
J165_00748	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
J165_00749	COG1846	Transcriptional regulator
J165_00750	COG1764	response to oxidative stress
J165_00755	COG2130	NADP-dependent
J165_00758	COG1187	pseudouridine synthase activity
J165_00762	COG1643	Atp-dependent helicase
J165_00763	COG4807	Protein conserved in bacteria
J165_00764	COG2351	hydroxyisourate hydrolase activity
J165_00765	COG2072	flavoprotein involved in K transport
J165_00769	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J165_00776	COG1957	nucleoside hydrolase
J165_00778	COG2252	PERMEase
J165_00782	COG0084	hydrolase, TatD family'
J165_00785	COG0583	DNA-binding transcription factor activity
J165_00786	COG2814	Major facilitator Superfamily
J165_00788	COG2267	carboxylic ester hydrolase activity
J165_00789	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J165_00790	COG1902	pentaerythritol trinitrate reductase activity
J165_00794	COG0745	RESPONSE REGULATOR receiver
J165_00795	COG2205	protein histidine kinase activity
J165_00796	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J165_00798	COG1538	Outer membrane efflux protein
J165_00800	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J165_00801	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J165_00802	COG0583	DNA-binding transcription factor activity
J165_00808	COG0702	epimerase
J165_00809	COG1733	regulation of RNA biosynthetic process
J165_00814	COG2963	transposase activity
J165_00816	COG0129	dihydroxy-acid dehydratase activity
J165_00819	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
J165_00830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J165_00831	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J165_00836	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
J165_00837	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
J165_00839	COG3485	protocatechuate 3,4-dioxygenase
J165_00840	COG3485	protocatechuate 3,4-dioxygenase
J165_00842	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J165_00843	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J165_00845	COG1414	Transcriptional regulator
J165_00849	COG0445	tRNA wobble uridine modification
J165_00857	COG2267	carboxylic ester hydrolase activity
J165_00859	COG0156	8-amino-7-oxononanoate synthase activity
J165_00860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J165_00861	COG1040	competence protein
J165_00862	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J165_00879	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J165_00893	COG1511	domain protein
J165_00893	COG3264	Mechanosensitive ion channel
J165_00894	COG1368	sulfuric ester hydrolase activity
J165_00895	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J165_00897	COG2354	Protein conserved in bacteria
J165_00898	COG3706	GGDEF domain
J165_00898	COG0745	RESPONSE REGULATOR receiver
J165_00899	COG0297	glycogen (starch) synthase activity
J165_00900	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J165_00901	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J165_00906	COG0702	epimerase
J165_00907	COG1028	Short-chain dehydrogenase reductase Sdr
J165_00913	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J165_00914	COG1028	Short-chain dehydrogenase reductase Sdr
J165_00916	COG0513	Belongs to the DEAD box helicase family
J165_00921	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J165_00923	COG3483	tryptophan 2,3-dioxygenase activity
J165_00924	COG3104	oligopeptide transport
J165_00928	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
J165_00931	COG1320	monovalent cation:proton antiporter activity
J165_00932	COG2212	antiporter activity
J165_00934	COG0651	ATP synthesis coupled electron transport
J165_00935	COG1006	Multisubunit Na H antiporter MnhC subunit
J165_00936	COG2111	Na H antiporter
J165_00936	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J165_00941	COG3179	chitinase
J165_00945	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J165_00946	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
J165_00950	COG1597	lipid kinase activity
J165_00955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J165_00956	COG0134	indole-3-glycerol-phosphate synthase activity
J165_00958	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J165_00959	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
J165_00961	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
J165_00962	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J165_00963	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J165_00966	COG1051	belongs to the nudix hydrolase family
J165_00973	COG0316	Belongs to the HesB IscA family
J165_00976	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
J165_00979	COG2814	Major facilitator Superfamily
J165_00980	COG0583	DNA-binding transcription factor activity
J165_00981	COG2814	Major facilitator Superfamily
J165_00982	COG1289	transmembrane transporter activity
J165_00983	COG0151	Belongs to the GarS family
J165_00985	COG0138	bifunctional purine biosynthesis protein purh
J165_00986	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J165_00987	COG2267	carboxylic ester hydrolase activity
J165_00988	COG0671	phosphoesterase, PA-phosphatase related
J165_00988	COG2453	phosphatase
J165_00993	COG4589	Belongs to the CDS family
J165_00994	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
J165_00999	COG2264	protein methyltransferase activity
J165_01003	COG0439	Biotin carboxylase
J165_01005	COG0511	ligase activity, forming carbon-carbon bonds
J165_01006	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
J165_01008	COG1324	tolerance protein
J165_01013	COG0300	oxidoreductase activity
J165_01014	COG2356	endonuclease I
J165_01015	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J165_01016	COG0459	protein refolding
J165_01019	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J165_01022	COG3386	PFAM SMP-30 Gluconolaconase
J165_01024	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
J165_01025	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J165_01028	COG0778	Nitroreductase
J165_01029	COG2353	YceI-like domain
J165_01034	COG3052	prosthetic group binding
J165_01038	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
J165_01040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J165_01042	COG1802	Transcriptional regulator
J165_01051	COG2801	Transposase and inactivated derivatives
J165_01052	COG2963	transposase activity
J165_01053	COG4221	oxidoreductase activity
J165_01056	COG4221	oxidoreductase activity
J165_01058	COG0435	Glutathione S-transferase
J165_01064	COG2963	transposase activity
J165_01065	COG2801	Transposase and inactivated derivatives
J165_01067	COG0308	aminopeptidase N
J165_01069	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J165_01072	COG4948	Mandelate Racemase Muconate Lactonizing
J165_01073	COG3250	beta-galactosidase activity
J165_01077	COG1970	mechanosensitive ion channel activity
J165_01081	COG0471	metal ion transport
J165_01081	COG3273	potassium ion transport
J165_01082	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J165_01083	COG2022	thiamine diphosphate biosynthetic process
J165_01090	COG3209	COG3209 Rhs family protein
J165_01096	COG3657	addiction module killer protein
J165_01104	COG2003	Belongs to the UPF0758 family
J165_01110	COG2189	Belongs to the N(4) N(6)-methyltransferase family
J165_01128	COG0189	ligase activity
J165_01130	COG0745	RESPONSE REGULATOR receiver
J165_01131	COG5002	protein histidine kinase activity
J165_01133	COG2963	transposase activity
J165_01136	COG0237	dephospho-CoA kinase activity
J165_01137	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
J165_01146	COG0045	succinate-CoA ligase (ADP-forming) activity
J165_01147	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
J165_01152	COG2369	cell adhesion
J165_01165	COG2963	transposase activity
J165_01202	COG0784	Response regulator, receiver
J165_01202	COG4191	Histidine kinase
J165_01215	COG4695	Portal protein
J165_01219	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J165_01221	COG2201	protein-glutamate methylesterase activity
J165_01222	COG3852	Histidine kinase
J165_01225	COG0544	peptidyl-prolyl cis-trans isomerase activity
J165_01226	COG0740	serine-type endopeptidase activity
J165_01227	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J165_01233	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J165_01236	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J165_01238	COG0328	RNA-DNA hybrid ribonuclease activity
J165_01239	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J165_01240	COG0631	protein serine/threonine phosphatase activity
J165_01243	COG0859	PFAM glycosyl transferase family 9
J165_01244	COG3642	lipopolysaccharide core region biosynthetic process
J165_01245	COG1234	tRNA 3'-trailer cleavage
J165_01246	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J165_01247	COG0315	cyclic pyranopterin monophosphate synthase activity
J165_01248	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
J165_01249	COG0314	molybdopterin synthase activity
J165_01252	COG2963	transposase activity
J165_01260	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
J165_01261	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J165_01262	COG0537	adenosine 5'-monophosphoramidase activity
J165_01266	COG0714	Associated with various cellular activities
J165_01271	COG0424	maF-like protein
J165_01272	COG1399	metal-binding, possibly nucleic acid-binding protein
J165_01273	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J165_01274	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J165_01277	COG1028	Short-chain dehydrogenase reductase Sdr
J165_01278	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J165_01280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J165_01281	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J165_01286	COG3829	transcription factor binding
J165_01290	COG3609	addiction module antidote protein, CC2985 family
J165_01295	COG2373	Large extracellular alpha-helical protein
J165_01298	COG4953	penicillin-binding protein 1C
J165_01300	COG0678	peroxiredoxin activity
J165_01306	COG0330	HflC and HflK could
J165_01307	COG0330	HflC and HflK could
J165_01310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J165_01311	COG0308	aminopeptidase N
J165_01313	COG1028	Short-chain dehydrogenase reductase Sdr
J165_01314	COG1309	transcriptional regulator
J165_01327	COG0328	RNA-DNA hybrid ribonuclease activity
J165_01327	COG0406	alpha-ribazole phosphatase activity
J165_01328	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J165_01330	COG3387	PFAM Glycoside hydrolase 15-related
J165_01331	COG1028	Short-chain dehydrogenase reductase Sdr
J165_01332	COG3537	Alpha-1,2-mannosidase
J165_01336	COG0492	ferredoxin-NADP+ reductase activity
J165_01341	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J165_01342	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J165_01343	COG2080	2 iron, 2 sulfur cluster binding
J165_01350	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J165_01353	COG0587	DNA-directed DNA polymerase activity
J165_01356	COG1297	OPT oligopeptide transporter protein
J165_01359	COG1506	peptidase
J165_01359	COG0823	Involved in the tonB-independent uptake of proteins
J165_01362	COG2207	Transcriptional regulator
J165_01362	COG1917	Cupin 2, conserved barrel domain protein
J165_01367	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J165_01369	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
J165_01370	COG0745	RESPONSE REGULATOR receiver
J165_01371	COG2205	protein histidine kinase activity
J165_01373	COG4452	Inner membrane protein CreD
J165_01378	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J165_01379	COG0735	belongs to the Fur family
J165_01382	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J165_01383	COG1538	Outer membrane efflux protein
J165_01384	COG1309	transcriptional regulator
J165_01386	COG2207	Transcriptional regulator
J165_01388	COG0583	DNA-binding transcription factor activity
J165_01389	COG2814	Major facilitator Superfamily
J165_01390	COG0667	Aldo Keto reductase
J165_01413	COG5001	Diguanylate cyclase
J165_01413	COG5002	protein histidine kinase activity
J165_01414	COG1187	pseudouridine synthase activity
J165_01415	COG0745	RESPONSE REGULATOR receiver
J165_01415	COG3706	GGDEF domain
J165_01418	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J165_01419	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J165_01420	COG0475	glutathione-regulated potassium exporter activity
J165_01421	COG5000	phosphorelay sensor kinase activity
J165_01421	COG5002	protein histidine kinase activity
J165_01422	COG0745	RESPONSE REGULATOR receiver
J165_01423	COG1538	Outer membrane efflux protein
J165_01429	COG1132	(ABC) transporter
J165_01436	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J165_01437	COG2155	Conserved Protein
J165_01442	COG3118	belongs to the thioredoxin family
J165_01444	COG0495	leucyl-tRNA aminoacylation
J165_01447	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J165_01450	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J165_01453	COG2968	Membrane
J165_01454	COG0424	maF-like protein
J165_01455	COG1530	ribonuclease E activity
J165_01456	COG3164	Protein of unknown function
J165_01458	COG0312	modulator of DNA gyrase
J165_01459	COG3028	Belongs to the UPF0307 family
J165_01460	COG0312	modulator of DNA gyrase
J165_01462	COG4104	PAAR repeat-containing protein
J165_01463	COG0142	geranyltranstransferase activity
J165_01464	COG1722	exodeoxyribonuclease VII activity
J165_01465	COG0037	tRNA processing
J165_01466	COG1785	Belongs to the alkaline phosphatase family
J165_01467	COG1301	dicarboxylic acid transport
J165_01468	COG4106	trans-aconitate 2-methyltransferase activity
J165_01470	COG0791	NLP P60 protein
J165_01471	COG0791	NLP P60 protein
J165_01472	COG1047	Peptidyl-prolyl cis-trans
J165_01473	COG2311	Membrane
J165_01474	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J165_01475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J165_01479	COG3590	peptidase
J165_01480	COG3590	peptidase
J165_01484	COG0489	protein tyrosine kinase activity
J165_01485	COG0717	Belongs to the dCTP deaminase family
J165_01490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J165_01491	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J165_01494	COG0494	nUDIX hydrolase
J165_01495	COG0433	COG0433 Predicted ATPase
J165_01497	COG0688	phosphatidylethanolamine metabolic process
J165_01499	COG2890	protein-(glutamine-N5) methyltransferase activity
J165_01500	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J165_01501	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J165_01502	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J165_01506	COG0101	tRNA pseudouridine synthase activity
J165_01507	COG0135	phosphoribosylanthranilate isomerase activity
J165_01509	COG0133	tryptophan synthase activity
J165_01511	COG0159	tryptophan synthase activity
J165_01512	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
J165_01513	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J165_01519	COG0300	oxidoreductase activity
J165_01520	COG0149	triose-phosphate isomerase activity
J165_01523	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J165_01524	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J165_01525	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J165_01526	COG0649	NAD binding
J165_01527	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
J165_01528	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J165_01530	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
J165_01531	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J165_01533	COG0713	ATP synthesis coupled electron transport
J165_01536	COG1007	ATP synthesis coupled electron transport
J165_01538	COG0779	Required for maturation of 30S ribosomal subunits
J165_01539	COG0195	Participates in both transcription termination and antitermination
J165_01540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J165_01541	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J165_01542	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J165_01543	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J165_01544	COG1185	polyribonucleotide nucleotidyltransferase activity
J165_01550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J165_01551	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J165_01553	COG2095	MarC family integral membrane protein
J165_01555	COG1611	Belongs to the LOG family
J165_01556	COG3275	phosphorelay sensor kinase activity
J165_01562	COG2963	transposase activity
J165_01569	COG2003	Belongs to the UPF0758 family
J165_01570	COG5489	Protein of unknown function (DUF736)
J165_01571	COG1396	sequence-specific DNA binding
J165_01572	COG2963	transposase activity
J165_01573	COG2801	Transposase and inactivated derivatives
J165_01574	COG3002	Belongs to the UPF0753 family
J165_01575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J165_01576	COG0583	DNA-binding transcription factor activity
J165_01579	COG2197	response regulator
J165_01582	COG1335	isochorismatase
J165_01585	COG2814	Major facilitator Superfamily
J165_01588	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J165_01588	COG1648	precorrin-2 dehydrogenase activity
J165_01592	COG3685	Protein conserved in bacteria
J165_01595	COG5001	Diguanylate cyclase
J165_01597	COG4566	intracellular signal transduction
J165_01605	COG3279	Response regulator of the LytR AlgR family
J165_01611	COG1238	metal cluster binding
J165_01613	COG2963	transposase activity
J165_01630	COG1028	Short-chain dehydrogenase reductase Sdr
J165_01632	COG2226	methyltransferase
J165_01632	COG1073	alpha beta
J165_01641	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
J165_01641	COG0316	Belongs to the HesB IscA family
J165_01642	COG2154	pterin-4-alpha-carbinolamine dehydratase
J165_01644	COG0428	transporter
J165_01645	COG3064	Membrane
J165_01647	COG1530	ribonuclease E activity
J165_01653	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
J165_01655	COG0582	viral genome integration into host DNA
J165_01656	COG2963	transposase activity
J165_01657	COG2801	Transposase and inactivated derivatives
J165_01660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J165_01661	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J165_01664	COG3039	Transposase
J165_01669	COG3039	Transposase
J165_01672	COG3039	Transposase
J165_01678	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J165_01681	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J165_01687	COG1192	Involved in chromosome partitioning
J165_01694	COG0629	single-stranded DNA binding
J165_01695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J165_01696	COG0270	DNA (cytosine-5-)-methyltransferase activity
J165_01708	COG2826	transposase and inactivated derivatives, IS30 family
J165_01736	COG2003	Belongs to the UPF0758 family
J165_01759	COG0583	DNA-binding transcription factor activity
J165_01760	COG1396	sequence-specific DNA binding
J165_01765	COG0582	viral genome integration into host DNA
J165_01767	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J165_01768	COG0322	excinuclease ABC activity
J165_01770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J165_01771	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
J165_01772	COG1663	tetraacyldisaccharide 4'-kinase activity
J165_01773	COG1132	(ABC) transporter
J165_01775	COG0811	peptide transport
J165_01778	COG1136	(ABC) transporter
J165_01779	COG4591	ABC-type transport system involved in lipoprotein release permease component
J165_01781	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
J165_01782	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J165_01785	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
J165_01790	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J165_01791	COG0837	glucose binding
J165_01792	COG0363	glucosamine-6-phosphate deaminase activity
J165_01793	COG0129	dihydroxy-acid dehydratase activity
J165_01794	COG0800	Aldolase
J165_01807	COG0784	Response regulator, receiver
J165_01807	COG2205	protein histidine kinase activity
J165_01808	COG2183	response to ionizing radiation
J165_01810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J165_01810	COG0723	plastoquinol--plastocyanin reductase activity
J165_01813	COG3243	poly(R)-hydroxyalkanoic acid synthase
J165_01815	COG1183	phosphatidylcholine synthase activity
J165_01816	COG1028	Short-chain dehydrogenase reductase Sdr
J165_01819	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
J165_01821	COG0668	transmembrane transport
J165_01822	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
J165_01823	COG0590	tRNA wobble adenosine to inosine editing
J165_01824	COG1321	iron dependent repressor
J165_01825	COG1914	H( )-stimulated, divalent metal cation uptake system
J165_01828	COG0746	molybdenum cofactor guanylyltransferase activity
J165_01829	COG0303	'Molybdopterin
J165_01831	COG0708	Exodeoxyribonuclease III
J165_01838	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J165_01839	COG0303	'Molybdopterin
J165_01840	COG1160	GTP binding
J165_01841	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J165_01843	COG1426	Protein conserved in bacteria
J165_01845	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J165_01846	COG0105	UTP biosynthetic process
J165_01848	COG1250	3-hydroxyacyl-CoA dehydrogenase
J165_01848	COG1024	Enoyl-CoA hydratase
J165_01849	COG0183	Belongs to the thiolase family
J165_01851	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J165_01853	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J165_01855	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
J165_01857	COG1674	ftsk spoiiie
J165_01858	COG0492	ferredoxin-NADP+ reductase activity
J165_01860	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
J165_01861	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J165_01862	COG0542	response to heat
J165_01863	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
J165_01865	COG0482	sulfurtransferase activity
J165_01866	COG2915	High frequency lysogenization protein hflD homolog
J165_01872	COG5002	protein histidine kinase activity
J165_01876	COG0784	Response regulator, receiver
J165_01876	COG0835	chemotaxis
J165_01878	COG1558	bacterial-type flagellum-dependent cell motility
J165_01879	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
J165_01880	COG1749	Flagellar hook protein flgE
J165_01881	COG4787	bacterial-type flagellum-dependent cell motility
J165_01882	COG4786	Flagellar basal body rod
J165_01883	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
J165_01884	COG1706	bacterial-type flagellum-dependent cell motility
J165_01885	COG3951	Flagellar rod assembly protein muramidase FlgJ
J165_01885	COG1705	Flagellar rod assembly protein muramidase FlgJ
J165_01887	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J165_01888	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J165_01889	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
J165_01895	COG2201	protein-glutamate methylesterase activity
J165_01896	COG2204	response regulator
J165_01899	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J165_01900	COG1028	Short-chain dehydrogenase reductase Sdr
J165_01901	COG1028	Short-chain dehydrogenase reductase Sdr
J165_01908	COG1677	Flagellar hook-basal body complex protein FliE
J165_01918	COG3190	flagellar
J165_01922	COG1987	bacterial-type flagellum assembly
J165_01923	COG1684	flagellar biosynthetic protein fliR
J165_01924	COG5001	Diguanylate cyclase
J165_01924	COG3300	MHYT domain
J165_01925	COG5001	Diguanylate cyclase
J165_01925	COG3300	MHYT domain
J165_01928	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J165_01930	COG0455	bacterial-type flagellum organization
J165_01934	COG2198	Histidine kinase
J165_01934	COG0643	Histidine kinase
J165_01936	COG0641	radical SAM
J165_01941	COG2963	transposase activity
J165_01951	COG0210	DNA helicase
J165_01967	COG2084	Dehydrogenase
J165_01972	COG2003	Belongs to the UPF0758 family
J165_01979	COG0582	viral genome integration into host DNA
J165_01980	COG0519	Catalyzes the synthesis of GMP from XMP
J165_01980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J165_01982	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J165_01984	COG0475	glutathione-regulated potassium exporter activity
J165_01984	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J165_01985	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J165_01987	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J165_01988	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
J165_01990	COG0776	regulation of translation
J165_01991	COG0539	negative regulation of cytoplasmic translation
J165_01992	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J165_01993	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J165_01996	COG2957	Belongs to the agmatine deiminase family
J165_01997	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J165_02002	COG0395	ABC-type sugar transport system, permease component
J165_02003	COG1175	transmembrane transport
J165_02009	COG2350	Protein conserved in bacteria
J165_02010	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
J165_02011	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J165_02012	COG1187	pseudouridine synthase activity
J165_02016	COG0436	Aminotransferase
J165_02017	COG4133	protoheme IX ABC transporter activity
J165_02021	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
J165_02022	COG1138	Cytochrome C-type biogenesis protein
J165_02026	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J165_02027	COG1278	Cold shock
J165_02028	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
J165_02029	COG4988	ABC transporter
J165_02031	COG1294	oxidase, subunit
J165_02036	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J165_02037	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J165_02039	COG0165	Argininosuccinate lyase
J165_02040	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J165_02042	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J165_02045	COG0137	argininosuccinate synthase activity
J165_02046	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J165_02048	COG0215	cysteine-tRNA ligase activity
J165_02049	COG2166	iron-sulfur cluster assembly
J165_02051	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J165_02052	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J165_02053	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J165_02058	COG4302	ethanolamine ammonia-lyase activity
J165_02064	COG2963	transposase activity
J165_02070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J165_02071	COG0402	S-adenosylhomocysteine deaminase activity
J165_02073	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J165_02074	COG1509	lysine 2,3-aminomutase activity
J165_02075	COG5001	Diguanylate cyclase
J165_02075	COG3300	MHYT domain
J165_02078	COG0483	inositol monophosphate 1-phosphatase activity
J165_02083	COG0513	Belongs to the DEAD box helicase family
J165_02084	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J165_02085	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
J165_02087	COG0625	glutathione transferase activity
J165_02089	COG4681	YaeQ
J165_02090	COG2081	HI0933 family
J165_02092	COG0501	Belongs to the peptidase M48B family
J165_02093	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J165_02094	COG1028	Short-chain dehydrogenase reductase Sdr
J165_02098	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J165_02099	COG0860	N-Acetylmuramoyl-L-alanine amidase
J165_02100	COG0802	atpase or kinase
J165_02101	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J165_02101	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J165_02102	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J165_02103	COG1570	exodeoxyribonuclease VII activity
J165_02105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J165_02144	COG0835	chemotaxis
J165_02145	COG0840	transmembrane signaling receptor activity
J165_02146	COG2094	Belongs to the DNA glycosylase MPG family
J165_02147	COG1201	RNA secondary structure unwinding
J165_02150	COG2969	positive regulation of protein catabolic process
J165_02151	COG0625	glutathione transferase activity
J165_02152	COG2857	Cytochrome c1
J165_02153	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J165_02154	COG0723	plastoquinol--plastocyanin reductase activity
J165_02155	COG0741	lytic transglycosylase activity
J165_02158	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J165_02159	COG1702	phosphate starvation-inducible protein PhoH
J165_02161	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J165_02163	COG4535	Mg2 and Co2 transporter CorC
J165_02166	COG1012	belongs to the aldehyde dehydrogenase family
J165_02167	COG1177	transmembrane transport
J165_02168	COG1176	ABC-type spermidine putrescine transport system, permease component I
J165_02169	COG3842	ATPase activity
J165_02173	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
J165_02176	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J165_02177	COG0174	glutamine synthetase
J165_02178	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J165_02179	COG0745	RESPONSE REGULATOR receiver
J165_02179	COG3706	GGDEF domain
J165_02180	COG2703	oxygen carrier activity
J165_02181	COG0477	Major facilitator Superfamily
J165_02183	COG0243	molybdopterin cofactor binding
J165_02184	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
J165_02188	COG2733	membrane
J165_02189	COG2205	protein histidine kinase activity
J165_02189	COG0784	Response regulator, receiver
J165_02189	COG5002	protein histidine kinase activity
J165_02191	COG0477	Major facilitator Superfamily
J165_02192	COG2902	Dehydrogenase
J165_02194	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J165_02195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J165_02196	COG1609	Transcriptional regulator
J165_02197	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J165_02197	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J165_02198	COG1105	Belongs to the carbohydrate kinase PfkB family
J165_02199	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J165_02199	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J165_02207	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J165_02209	COG1862	Preprotein translocase
J165_02210	COG0343	queuine tRNA-ribosyltransferase activity
J165_02211	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
J165_02219	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
J165_02220	COG3291	Pkd domain containing protein
J165_02221	COG0405	Gamma-glutamyltransferase
J165_02222	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J165_02225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J165_02226	COG0742	ribosomal rna small subunit methyltransferase
J165_02227	COG0326	Molecular chaperone. Has ATPase activity
J165_02243	COG0531	amino acid
J165_02246	COG0006	proline dipeptidase activity
J165_02248	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J165_02251	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J165_02252	COG3938	Belongs to the proline racemase family
J165_02254	COG0552	protein localization to endoplasmic reticulum
J165_02255	COG1194	a g-specific adenine glycosylase
J165_02256	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
J165_02257	COG0784	Response regulator, receiver
J165_02257	COG4191	Histidine kinase
J165_02260	COG0322	excinuclease ABC activity
J165_02263	COG3040	lipid binding
J165_02265	COG1960	acyl-CoA dehydrogenase activity
J165_02267	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J165_02271	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J165_02272	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J165_02273	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J165_02280	COG0438	transferase activity, transferring glycosyl groups
J165_02281	COG0438	transferase activity, transferring glycosyl groups
J165_02290	COG0776	regulation of translation
J165_02291	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J165_02291	COG0072	phenylalanine-tRNA ligase activity
J165_02292	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J165_02293	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J165_02294	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J165_02296	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J165_02297	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J165_02302	COG1082	Xylose isomerase domain protein TIM barrel
J165_02306	COG0366	Alpha amylase catalytic
J165_02307	COG2963	transposase activity
J165_02308	COG2801	Transposase and inactivated derivatives
J165_02311	COG0477	Major facilitator Superfamily
J165_02312	COG2115	Belongs to the xylose isomerase family
J165_02313	COG1070	Carbohydrate kinase
J165_02315	COG1501	Belongs to the glycosyl hydrolase 31 family
J165_02323	COG0800	Aldolase
J165_02324	COG4948	Mandelate Racemase Muconate Lactonizing
J165_02326	COG3734	2-keto-3-deoxy-galactonokinase
J165_02327	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
J165_02329	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J165_02332	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J165_02333	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
J165_02336	COG0351	phosphomethylpyrimidine kinase
J165_02336	COG0352	thiamine-phosphate diphosphorylase activity
J165_02341	COG0583	DNA-binding transcription factor activity
J165_02342	COG1741	Belongs to the pirin family
J165_02345	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
J165_02346	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J165_02347	COG2137	regulation of response to DNA damage stimulus
J165_02348	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J165_02349	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J165_02351	COG1546	Belongs to the CinA family
J165_02352	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J165_02353	COG1923	regulation of RNA biosynthetic process
J165_02354	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J165_02355	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J165_02356	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J165_02357	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
J165_02358	COG1534	Rna-binding protein
J165_02362	COG1238	metal cluster binding
J165_02363	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J165_02364	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
J165_02365	COG2840	Smr protein MutS2
J165_02366	COG0585	pseudouridine synthase activity
J165_02367	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J165_02368	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J165_02369	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
J165_02370	COG0148	phosphopyruvate hydratase activity
J165_02372	COG2877	3-deoxy-8-phosphooctulonate synthase activity
J165_02373	COG0504	CTP synthase activity
J165_02378	COG0306	phosphate transporter
J165_02380	COG1253	flavin adenine dinucleotide binding
J165_02383	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J165_02384	COG0477	Major facilitator Superfamily
J165_02386	COG1136	(ABC) transporter
J165_02389	COG0438	transferase activity, transferring glycosyl groups
J165_02391	COG2264	protein methyltransferase activity
J165_02397	COG2244	polysaccharide biosynthetic process
J165_02408	COG1595	DNA-templated transcription, initiation
J165_02411	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J165_02413	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
J165_02415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J165_02418	COG0784	Response regulator, receiver
J165_02418	COG4191	Histidine kinase
J165_02419	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
J165_02420	COG0745	RESPONSE REGULATOR receiver
J165_02424	COG0840	transmembrane signaling receptor activity
J165_02429	COG2801	Transposase and inactivated derivatives
J165_02430	COG2963	transposase activity
J165_02431	COG1396	sequence-specific DNA binding
J165_02432	COG5489	Protein of unknown function (DUF736)
J165_02433	COG2003	Belongs to the UPF0758 family
J165_02438	COG0582	viral genome integration into host DNA
J165_02441	COG4774	siderophore transport
J165_02445	COG2336	PFAM SpoVT AbrB
J165_02450	COG4206	TonB-dependent receptor
J165_02454	COG2273	Hydrolase Family 16
J165_02454	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
J165_02458	COG2274	protein secretion by the type I secretion system
J165_02460	COG1192	Involved in chromosome partitioning
J165_02469	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J165_02471	COG0270	DNA (cytosine-5-)-methyltransferase activity
J165_02483	COG4804	nuclease activity
J165_02484	COG2963	transposase activity
J165_02485	COG2801	Transposase and inactivated derivatives
J165_02498	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
J165_02499	COG1360	Flagellar Motor Protein
J165_02500	COG1192	Involved in chromosome partitioning
J165_02501	COG0835	chemotaxis
J165_02503	COG0745	RESPONSE REGULATOR receiver
J165_02504	COG0643	Histidine kinase
J165_02504	COG2198	Histidine kinase
J165_02505	COG0840	transmembrane signaling receptor activity
J165_02507	COG0840	transmembrane signaling receptor activity
J165_02507	COG0840	transmembrane signaling receptor activity
J165_02508	COG0840	transmembrane signaling receptor activity
J165_02510	COG0840	transmembrane signaling receptor activity
J165_02511	COG0840	transmembrane signaling receptor activity
J165_02512	COG0840	transmembrane signaling receptor activity
J165_02513	COG0840	transmembrane signaling receptor activity
J165_02514	COG0840	transmembrane signaling receptor activity
J165_02515	COG0840	transmembrane signaling receptor activity
J165_02516	COG0840	transmembrane signaling receptor activity
J165_02517	COG0840	transmembrane signaling receptor activity
J165_02518	COG0840	transmembrane signaling receptor activity
J165_02520	COG0835	chemotaxis
J165_02522	COG0840	transmembrane signaling receptor activity
J165_02524	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
J165_02525	COG2201	protein-glutamate methylesterase activity
J165_02527	COG2267	carboxylic ester hydrolase activity
J165_02533	COG0318	PFAM AMP-dependent synthetase and ligase
J165_02534	COG1024	Enoyl-CoA hydratase
J165_02535	COG0784	Response regulator, receiver
J165_02535	COG2198	Histidine kinase
J165_02535	COG2205	protein histidine kinase activity
J165_02537	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J165_02538	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
J165_02539	COG3279	Response regulator of the LytR AlgR family
J165_02547	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J165_02549	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J165_02550	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J165_02552	COG0505	Belongs to the CarA family
J165_02553	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J165_02554	COG2258	MOSC domain
J165_02555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J165_02564	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J165_02568	COG0277	FAD linked oxidase domain protein
J165_02569	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J165_02571	COG0531	amino acid
J165_02572	COG0531	amino acid
J165_02573	COG0235	Class ii aldolase
J165_02574	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
J165_02575	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
J165_02578	COG0140	phosphoribosyl-ATP diphosphatase activity
J165_02578	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J165_02579	COG0107	imidazoleglycerol-phosphate synthase activity
J165_02580	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J165_02581	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J165_02582	COG0131	Imidazoleglycerol-phosphate dehydratase
J165_02582	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
J165_02583	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J165_02584	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J165_02585	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J165_02587	COG0124	histidyl-tRNA synthetase
J165_02588	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J165_02597	COG3210	domain, Protein
J165_02598	COG3210	domain, Protein
J165_02601	COG0726	polysaccharide deacetylase
J165_02601	COG1649	PFAM Uncharacterised BCR, COG1649
J165_02602	COG1215	transferase activity, transferring glycosyl groups
J165_02605	COG1012	belongs to the aldehyde dehydrogenase family
J165_02608	COG0167	dihydroorotate dehydrogenase activity
J165_02609	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J165_02610	COG0697	spore germination
J165_02611	COG1794	racemase activity, acting on amino acids and derivatives
J165_02613	COG0671	phosphoesterase, PA-phosphatase related
J165_02614	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J165_02616	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
J165_02617	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J165_02618	COG5001	Diguanylate cyclase
J165_02618	COG2203	Gaf domain
J165_02618	COG4251	negative regulation of phosphorylation
J165_02618	COG3706	GGDEF domain
J165_02620	COG1472	Belongs to the glycosyl hydrolase 3 family
J165_02624	COG0166	Belongs to the GPI family
J165_02625	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
J165_02626	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
J165_02627	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J165_02633	COG1469	GTP cyclohydrolase I activity
J165_02634	COG0860	N-Acetylmuramoyl-L-alanine amidase
J165_02636	COG0366	Alpha amylase catalytic
J165_02638	COG2963	transposase activity
J165_02639	COG2801	Transposase and inactivated derivatives
J165_02652	COG2948	multi-organism process
J165_02656	COG3505	Type IV secretory pathway VirD4
J165_02659	COG0556	nucleotide-excision repair
J165_02667	COG2963	transposase activity
J165_02668	COG2801	Transposase and inactivated derivatives
J165_02674	COG0583	DNA-binding transcription factor activity
J165_02675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J165_02676	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J165_02679	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J165_02680	COG0077	Prephenate dehydratase
J165_02680	COG1605	Chorismate mutase
J165_02681	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
J165_02682	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J165_02683	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
J165_02691	COG1228	amidohydrolase
J165_02692	COG2986	histidine ammonia-lyase
J165_02694	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
J165_02697	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
J165_02699	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
J165_02700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J165_02701	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J165_02703	COG3115	cell septum assembly
J165_02705	COG0359	binds to the 23S rRNA
J165_02706	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J165_02707	COG0360	Binds together with S18 to 16S ribosomal RNA
J165_02708	COG0316	Belongs to the HesB IscA family
J165_02709	COG0017	Asparaginyl-tRNA synthetase
J165_02713	COG2808	Putative FMN-binding domain
J165_02725	COG0288	reversible hydration of carbon dioxide
J165_02726	COG0662	Cupin 2, conserved barrel domain protein
J165_02728	COG3844	kynureninase activity
J165_02729	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J165_02730	COG2925	Exonuclease
J165_02734	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J165_02735	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J165_02735	COG0116	Belongs to the methyltransferase superfamily
J165_02743	COG0494	nUDIX hydrolase
J165_02745	COG1024	Enoyl-CoA hydratase
J165_02747	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J165_02748	COG0659	secondary active sulfate transmembrane transporter activity
J165_02753	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J165_02754	COG0573	inorganic phosphate transmembrane transporter activity
J165_02755	COG0581	inorganic phosphate transmembrane transporter activity
J165_02756	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J165_02757	COG0704	Plays a role in the regulation of phosphate uptake
J165_02759	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J165_02760	COG3706	GGDEF domain
J165_02761	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J165_02763	COG0557	exoribonuclease II activity
J165_02766	COG1960	acyl-CoA dehydrogenase activity
J165_02768	COG0646	methionine synthase
J165_02768	COG1410	methionine synthase
J165_02769	COG1410	methionine synthase
J165_02769	COG0646	methionine synthase
J165_02771	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J165_02776	COG2900	Belongs to the SlyX family
J165_02779	COG0386	Belongs to the glutathione peroxidase family
J165_02781	COG1725	Transcriptional regulator
J165_02782	COG1131	(ABC) transporter
J165_02788	COG1253	flavin adenine dinucleotide binding
J165_02792	COG2850	peptidyl-arginine hydroxylation
J165_02799	COG1132	(ABC) transporter
J165_02800	COG0583	DNA-binding transcription factor activity
J165_02806	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
J165_02808	COG0484	heat shock protein binding
J165_02809	COG0443	Heat shock 70 kDa protein
J165_02810	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J165_02811	COG1420	regulation of RNA biosynthetic process
J165_02812	COG0497	DNA recombination
J165_02814	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J165_02817	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J165_02846	COG3706	GGDEF domain
J165_02848	COG3706	GGDEF domain
J165_02855	COG0583	DNA-binding transcription factor activity
J165_02858	COG0415	Belongs to the DNA photolyase family
J165_02859	COG0305	Participates in initiation and elongation during chromosome replication
J165_02861	COG0367	asparagine synthase
J165_02864	COG1960	acyl-CoA dehydrogenase activity
J165_02867	COG0084	hydrolase, TatD family'
J165_02868	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J165_02879	COG0386	Belongs to the glutathione peroxidase family
J165_02880	COG0339	signal peptide processing
J165_02886	COG3104	oligopeptide transport
J165_02890	COG2814	Major facilitator Superfamily
J165_02891	COG1566	PFAM secretion protein HlyD family protein
J165_02897	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J165_02900	COG4774	siderophore transport
J165_02902	COG0367	asparagine synthase
J165_02903	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J165_02904	COG1393	Belongs to the ArsC family
J165_02906	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
J165_02907	COG0024	Methionine aminopeptidase
J165_02914	COG0052	Belongs to the universal ribosomal protein uS2 family
J165_02915	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J165_02916	COG3706	GGDEF domain
J165_02916	COG0745	RESPONSE REGULATOR receiver
J165_02917	COG0528	UMP kinase activity
J165_02918	COG0233	cytoplasmic translational termination
J165_02919	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J165_02920	COG0575	Belongs to the CDS family
J165_02921	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J165_02922	COG0750	zinc metalloprotease
J165_02925	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J165_02926	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J165_02927	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J165_02928	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J165_02929	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J165_02931	COG0825	malonyl-CoA metabolic process
J165_02938	COG1695	Transcriptional regulator
J165_02942	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J165_02944	COG2040	homocysteine
J165_02945	COG0833	amino acid
J165_02946	COG0346	lactoylglutathione lyase activity
J165_02947	COG1131	(ABC) transporter
J165_02950	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J165_02950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J165_02952	COG2878	Part of a membrane complex involved in electron transport
J165_02955	COG1595	DNA-templated transcription, initiation
J165_02960	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J165_02963	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J165_02964	COG0251	oxidation-reduction process
J165_02967	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
J165_02967	COG0392	lysyltransferase activity
J165_02974	COG2814	Major facilitator Superfamily
J165_02975	COG1902	pentaerythritol trinitrate reductase activity
J165_02976	COG2824	Alkylphosphonate utilization operon protein PhnA
J165_02978	COG1047	Peptidyl-prolyl cis-trans
J165_02979	COG1077	Cell shape determining protein MreB Mrl
J165_02982	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J165_02984	COG5487	UPF0391 membrane protein
J165_02985	COG1451	nucleotide metabolic process
J165_02989	COG0183	Belongs to the thiolase family
J165_02992	COG0745	RESPONSE REGULATOR receiver
J165_02992	COG3706	GGDEF domain
J165_02995	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J165_02995	COG1793	dna ligase
J165_02997	COG1793	dna ligase
J165_02998	COG1201	RNA secondary structure unwinding
J165_03000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J165_03001	COG1278	Cold shock
J165_03002	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
J165_03004	COG1472	Belongs to the glycosyl hydrolase 3 family
J165_03005	COG3046	protein related to deoxyribodipyrimidine photolyase
J165_03006	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
J165_03007	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J165_03009	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J165_03011	COG1381	Involved in DNA repair and RecF pathway recombination
J165_03012	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J165_03013	COG0571	ribonuclease III activity
J165_03016	COG0481	GTPase activity
J165_03017	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J165_03020	COG1250	3-hydroxyacyl-CoA dehydrogenase
J165_03020	COG1024	Enoyl-CoA hydratase
J165_03024	COG1024	Enoyl-CoA hydratase
J165_03025	COG1960	acyl-CoA dehydrogenase activity
J165_03029	COG3867	Arabinogalactan endo-beta-1,4-galactanase
J165_03030	COG3250	beta-galactosidase activity
J165_03034	COG3209	COG3209 Rhs family protein
J165_03037	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J165_03039	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
J165_03043	COG0534	Mate efflux family protein
J165_03044	COG0335	large ribosomal subunit rRNA binding
J165_03045	COG0336	Belongs to the RNA methyltransferase TrmD family
J165_03046	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J165_03047	COG0228	four-way junction DNA binding
J165_03048	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J165_03050	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J165_03051	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J165_03056	COG0784	Response regulator, receiver
J165_03056	COG4191	Histidine kinase
J165_03057	COG3850	Histidine kinase
J165_03057	COG4999	Histidine kinase
J165_03057	COG3437	response regulator, receiver
J165_03057	COG2205	protein histidine kinase activity
J165_03058	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J165_03060	COG2205	protein histidine kinase activity
J165_03061	COG5507	3-demethylubiquinone-9 3-methyltransferase
J165_03063	COG4771	TonB-dependent receptor
J165_03068	COG2172	sigma factor antagonist activity
J165_03069	COG1366	Belongs to the anti-sigma-factor antagonist family
J165_03070	COG1366	Belongs to the anti-sigma-factor antagonist family
J165_03072	COG0326	Molecular chaperone. Has ATPase activity
J165_03073	COG2207	Transcriptional regulator
J165_03075	COG3152	Membrane
J165_03078	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
J165_03079	COG1845	cytochrome c oxidase, subunit III
J165_03080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J165_03083	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J165_03084	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J165_03085	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J165_03086	COG0196	riboflavin kinase activity
J165_03088	COG0268	Binds directly to 16S ribosomal RNA
J165_03089	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J165_03090	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J165_03091	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J165_03092	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J165_03093	COG0824	Thioesterase
J165_03096	COG1946	Acyl-CoA thioesterase
J165_03101	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
J165_03103	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
J165_03108	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
J165_03111	COG2197	response regulator
J165_03112	COG4585	Histidine kinase
J165_03114	COG0850	regulation of cytokinetic process
J165_03115	COG2894	cell division
J165_03116	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
J165_03118	COG0642	Histidine kinase
J165_03119	COG0745	RESPONSE REGULATOR receiver
J165_03122	COG2194	sulfuric ester hydrolase activity
J165_03125	COG2814	Major facilitator Superfamily
J165_03128	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J165_03128	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J165_03130	COG0656	L-ascorbic acid biosynthetic process
J165_03131	COG0753	catalase activity
J165_03139	COG0643	Histidine kinase
J165_03139	COG2198	Histidine kinase
J165_03140	COG0840	transmembrane signaling receptor activity
J165_03141	COG0835	chemotaxis
J165_03142	COG2202	Pas domain
J165_03142	COG2200	EAL domain
J165_03142	COG2199	diguanylate cyclase activity
J165_03143	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J165_03144	COG2201	protein-glutamate methylesterase activity
J165_03145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J165_03146	COG3590	peptidase
J165_03148	COG0588	phosphoglycerate mutase activity
J165_03149	COG1515	deoxyribonuclease V activity
J165_03151	COG1741	Belongs to the pirin family
J165_03154	COG1741	Belongs to the pirin family
J165_03155	COG1966	Carbon starvation protein
J165_03156	COG2879	small protein
J165_03164	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
J165_03165	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J165_03166	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J165_03167	COG2080	2 iron, 2 sulfur cluster binding
J165_03169	COG2203	Gaf domain
J165_03169	COG4251	negative regulation of phosphorylation
J165_03169	COG3706	GGDEF domain
J165_03169	COG5001	Diguanylate cyclase
J165_03170	COG0629	single-stranded DNA binding
J165_03171	COG0142	geranyltranstransferase activity
J165_03173	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J165_03176	COG0527	aspartate kinase activity
J165_03177	COG0384	phenazine biosynthesis protein PhzF
J165_03178	COG0384	phenazine biosynthesis protein PhzF
J165_03180	COG1764	response to oxidative stress
J165_03181	COG0540	Belongs to the ATCase OTCase family
J165_03182	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J165_03183	COG1678	Uncharacterized ACR, COG1678
J165_03184	COG0519	Catalyzes the synthesis of GMP from XMP
J165_03187	COG5297	Belongs to the glycosyl hydrolase family 6
J165_03190	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J165_03193	COG0739	heme binding
J165_03197	COG0693	protein deglycase activity
J165_03199	COG1959	2 iron, 2 sulfur cluster binding
J165_03200	COG0719	Fe-S assembly protein
J165_03201	COG0396	ATPase activity
J165_03202	COG0719	Fe-S assembly protein
J165_03203	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J165_03206	COG4774	siderophore transport
J165_03207	COG3128	pkhd-type hydroxylase
J165_03212	COG1477	protein flavinylation
J165_03213	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J165_03216	COG1555	photosystem II stabilization
J165_03217	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J165_03219	COG3178	'Phosphotransferase
J165_03220	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J165_03222	COG0628	permease
J165_03224	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J165_03226	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J165_03230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J165_03231	COG0271	Belongs to the BolA IbaG family
J165_03233	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
J165_03235	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
J165_03236	COG1137	ATPase activity
J165_03239	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J165_03240	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
J165_03241	COG1660	Displays ATPase and GTPase activities
J165_03243	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J165_03244	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J165_03245	COG2239	Acts as a magnesium transporter
J165_03247	COG1294	oxidase, subunit
J165_03248	COG1271	oxidase subunit
J165_03250	COG1113	amino acid transport
J165_03253	COG2197	response regulator
J165_03254	COG0531	amino acid
J165_03259	COG1234	tRNA 3'-trailer cleavage
J165_03266	COG2814	Major facilitator Superfamily
J165_03268	COG0754	glutathionylspermidine amidase activity
J165_03273	COG1842	Phage shock protein A
J165_03275	COG0259	pyridoxamine-phosphate oxidase activity
J165_03276	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J165_03277	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J165_03279	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J165_03293	COG0477	Major facilitator Superfamily
J165_03297	COG2198	Histidine kinase
J165_03297	COG0784	Response regulator, receiver
J165_03297	COG2205	protein histidine kinase activity
J165_03298	COG2353	YceI-like domain
J165_03302	COG1760	l-serine dehydratase
J165_03304	COG0460	homoserine dehydrogenase
J165_03304	COG0527	aspartate kinase activity
J165_03305	COG0626	cystathionine gamma-synthase activity
J165_03306	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J165_03308	COG0739	heme binding
J165_03309	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J165_03310	COG1272	protein, Hemolysin III
J165_03311	COG2982	Protein involved in outer membrane biogenesis
J165_03312	COG0516	GMP reductase activity
J165_03312	COG0517	IMP dehydrogenase activity
J165_03313	COG0463	Glycosyl transferase, family 2
J165_03314	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J165_03315	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
J165_03317	COG4771	TonB-dependent receptor
J165_03319	COG1309	transcriptional regulator
J165_03320	COG2267	carboxylic ester hydrolase activity
J165_03321	COG1960	acyl-CoA dehydrogenase activity
J165_03326	COG0509	glycine decarboxylation via glycine cleavage system
J165_03327	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J165_03329	COG0330	HflC and HflK could
J165_03330	COG1742	UPF0060 membrane protein
J165_03331	COG3956	TIGRFAM MazG family protein
J165_03333	COG0494	nUDIX hydrolase
J165_03335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J165_03336	COG0837	glucose binding
J165_03339	COG1388	LysM domain
J165_03339	COG3858	chitin binding
J165_03340	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J165_03342	COG1472	Belongs to the glycosyl hydrolase 3 family
J165_03345	COG0531	amino acid
J165_03347	COG1486	melibiose metabolic process
J165_03349	COG3537	Alpha-1,2-mannosidase
J165_03356	COG3142	Participates in the control of copper homeostasis
J165_03357	COG1446	asparaginase
J165_03362	COG0840	transmembrane signaling receptor activity
J165_03366	COG0189	ligase activity
J165_03368	COG1397	ADP-ribosylglycohydrolase
J165_03370	COG1199	ATP-dependent helicase activity
J165_03372	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J165_03373	COG1215	transferase activity, transferring glycosyl groups
J165_03375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J165_03376	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
J165_03377	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
J165_03378	COG0535	radical SAM domain protein
J165_03379	COG0535	radical SAM domain protein
J165_03382	COG0837	glucose binding
J165_03384	COG1643	Atp-dependent helicase
J165_03385	COG0783	Belongs to the Dps family
J165_03386	COG0514	ATP-dependent DNA helicase (RecQ)
J165_03393	COG0840	transmembrane signaling receptor activity
J165_03397	COG3920	Histidine kinase
J165_03398	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
J165_03400	COG0602	queuosine metabolic process
J165_03402	COG2885	chlorophyll binding
J165_03403	COG0823	Involved in the tonB-independent uptake of proteins
J165_03405	COG0848	biopolymer transport protein
J165_03407	COG0824	Thioesterase
J165_03408	COG2255	four-way junction helicase activity
J165_03410	COG3158	transport of potassium into the cell
J165_03411	COG0632	four-way junction helicase activity
J165_03412	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J165_03413	COG0217	transcriptional regulatory protein
J165_03416	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J165_03419	COG0477	Major facilitator Superfamily
J165_03427	COG0488	(ABC) transporter
J165_03433	COG4651	solute:proton antiporter activity
J165_03433	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J165_03438	COG4772	TonB-dependent receptor
J165_03440	COG4264	IucA IucC family
J165_03443	COG0019	diaminopimelate decarboxylase activity
J165_03448	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
J165_03450	COG1492	cobalamin metabolic process
J165_03453	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
J165_03457	COG4206	TonB-dependent receptor
J165_03459	COG0542	response to heat
J165_03460	COG1116	anion transmembrane transporter activity
J165_03461	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J165_03462	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J165_03463	COG0667	Aldo Keto reductase
J165_03465	COG4771	TonB-dependent receptor
J165_03466	COG2827	Endonuclease containing a URI domain
J165_03474	COG1877	trehalose-phosphatase activity
J165_03475	COG3387	PFAM Glycoside hydrolase 15-related
J165_03478	COG0840	transmembrane signaling receptor activity
J165_03479	COG3011	Protein conserved in bacteria
J165_03482	COG0564	pseudouridine synthase activity
J165_03483	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J165_03485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J165_03485	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
J165_03487	COG2963	transposase activity
J165_03488	COG2801	Transposase and inactivated derivatives
J165_03491	COG2951	lytic endotransglycosylase activity
J165_03492	COG4644	lycopene metabolic process
J165_03506	COG2963	transposase activity
J165_03513	COG0473	3-isopropylmalate dehydrogenase activity
J165_03516	COG4783	chaperone-mediated protein folding
J165_03519	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J165_03521	COG0438	transferase activity, transferring glycosyl groups
J165_03522	COG0671	phosphoesterase, PA-phosphatase related
J165_03524	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J165_03526	COG3291	Pkd domain containing protein
J165_03528	COG2833	Protein of unknown function (DUF455)
J165_03532	COG0285	dihydrofolate synthase activity
J165_03533	COG0406	alpha-ribazole phosphatase activity
J165_03538	COG1063	alcohol dehydrogenase
J165_03540	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J165_03541	COG4208	sulfate ABC transporter
J165_03542	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
J165_03543	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
J165_03544	COG0156	8-amino-7-oxononanoate synthase activity
J165_03549	COG0604	alcohol dehydrogenase
J165_03550	COG0446	pyridine nucleotide-disulphide oxidoreductase
J165_03550	COG1902	pentaerythritol trinitrate reductase activity
J165_03552	COG0625	glutathione transferase activity
J165_03553	COG0039	L-malate dehydrogenase activity
J165_03554	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J165_03557	COG0154	amidase activity
J165_03559	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
J165_03561	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
J165_03562	COG0203	ribosomal protein L17
J165_03563	COG0202	RNA polymerase activity
J165_03564	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J165_03565	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J165_03566	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J165_03567	COG0201	protein transport
J165_03568	COG0200	Binds to the 23S rRNA
J165_03569	COG1841	ribosomal large subunit assembly
J165_03570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J165_03571	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J165_03572	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J165_03573	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J165_03574	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J165_03575	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J165_03576	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J165_03577	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J165_03578	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J165_03579	COG0255	Belongs to the universal ribosomal protein uL29 family
J165_03580	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J165_03581	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J165_03582	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J165_03583	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J165_03584	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J165_03585	COG0089	rRNA binding
J165_03586	COG0088	Forms part of the polypeptide exit tunnel
J165_03587	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J165_03588	COG0051	transcription antitermination factor activity, RNA binding
J165_03589	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J165_03590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J165_03591	COG0049	tRNA binding
J165_03592	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J165_03593	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J165_03594	COG0085	RNA polymerase activity
J165_03596	COG0222	ribosome binding
J165_03597	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J165_03598	COG0081	regulation of translation
J165_03599	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J165_03600	COG0250	Participates in transcription elongation, termination and antitermination
J165_03601	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J165_03603	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J165_03607	COG0012	GTP binding
J165_03608	COG0193	aminoacyl-tRNA hydrolase activity
J165_03609	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J165_03610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J165_03612	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J165_03613	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
J165_03615	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
J165_03616	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J165_03618	COG0521	Mo-molybdopterin cofactor biosynthetic process
J165_03621	COG1254	Belongs to the acylphosphatase family
J165_03622	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J165_03623	COG1295	ribonuclease BN
J165_03629	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J165_03630	COG1404	Belongs to the peptidase S8 family
J165_03631	COG1404	Belongs to the peptidase S8 family
J165_03632	COG1404	Belongs to the peptidase S8 family
J165_03633	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J165_03636	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
J165_03637	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J165_03641	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J165_03647	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J165_03647	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J165_03651	COG2890	protein-(glutamine-N5) methyltransferase activity
J165_03653	COG3634	alkyl hydroperoxide reductase activity
J165_03654	COG0583	DNA-binding transcription factor activity
J165_03655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J165_03656	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J165_03658	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J165_03660	COG2197	response regulator
J165_03661	COG2205	protein histidine kinase activity
J165_03661	COG0784	Response regulator, receiver
J165_03661	COG5002	protein histidine kinase activity
J165_03662	COG0745	RESPONSE REGULATOR receiver
J165_03662	COG3706	GGDEF domain
J165_03665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J165_03666	COG0697	spore germination
J165_03669	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
J165_03671	COG3386	PFAM SMP-30 Gluconolaconase
J165_03675	COG1024	Enoyl-CoA hydratase
J165_03677	COG0318	PFAM AMP-dependent synthetase and ligase
J165_03678	COG0583	DNA-binding transcription factor activity
J165_03679	COG3384	dioxygenase
J165_03685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J165_03686	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J165_03688	COG2096	Adenosyltransferase
J165_03689	COG0123	including yeast histone deacetylase and acetoin utilization protein
J165_03692	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
J165_03693	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J165_03694	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
J165_03695	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J165_03696	COG2967	ApaG domain
J165_03697	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J165_03701	COG0747	negative chemotaxis
J165_03706	COG0431	NADPH-dependent FMN reductase
J165_03707	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J165_03709	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J165_03710	COG1116	anion transmembrane transporter activity
J165_03712	COG3829	transcription factor binding
J165_03715	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J165_03716	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J165_03720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J165_03722	COG0642	Histidine kinase
J165_03725	COG4181	ATPase activity
J165_03727	COG2175	clavaminate synthase activity
J165_03729	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
J165_03730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J165_03734	COG4771	TonB-dependent receptor
J165_03736	COG0667	Aldo Keto reductase
J165_03737	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
J165_03738	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J165_03741	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J165_03742	COG4106	trans-aconitate 2-methyltransferase activity
J165_03744	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J165_03750	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
J165_03753	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J165_03754	COG2226	methyltransferase
J165_03760	COG0366	Alpha amylase catalytic
J165_03764	COG3321	synthase
J165_03764	COG0604	alcohol dehydrogenase
J165_03764	COG1028	Short-chain dehydrogenase reductase Sdr
J165_03767	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J165_03769	COG0494	nUDIX hydrolase
J165_03770	COG0653	protein targeting
J165_03771	COG0739	heme binding
J165_03773	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
J165_03776	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J165_03777	COG1181	Belongs to the D-alanine--D-alanine ligase family
J165_03778	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J165_03779	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J165_03780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J165_03782	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J165_03783	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J165_03784	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J165_03786	COG3116	cell division
J165_03787	COG0275	rRNA processing
J165_03788	COG2001	Belongs to the MraZ family
J165_03796	COG0792	nuclease activity
J165_03797	COG1988	membrane-bound metal-dependent
J165_03798	COG0277	FAD linked oxidase domain protein
J165_03801	COG0745	RESPONSE REGULATOR receiver
J165_03802	COG2205	protein histidine kinase activity
J165_03803	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
J165_03804	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
J165_03805	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
J165_03809	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
J165_03810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J165_03811	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J165_03816	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J165_03816	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J165_03818	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J165_03819	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J165_03821	COG0488	(ABC) transporter
J165_03823	COG0697	spore germination
J165_03825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J165_03827	COG3791	Glutathione-dependent formaldehyde-activating
J165_03832	COG0745	RESPONSE REGULATOR receiver
J165_03833	COG2205	protein histidine kinase activity
J165_03836	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J165_03837	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J165_03841	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J165_03843	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J165_03844	COG1012	belongs to the aldehyde dehydrogenase family
J165_03845	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
J165_03846	COG0617	tRNA 3'-terminal CCA addition
J165_03848	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J165_03849	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J165_03850	COG1609	Transcriptional regulator
J165_03856	COG3250	beta-galactosidase activity
J165_03866	COG1459	type II secretion system
J165_03877	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J165_03878	COG4191	Histidine kinase
J165_03879	COG0784	Response regulator, receiver
J165_03880	COG4251	negative regulation of phosphorylation
J165_03881	COG2823	Periplasmic or secreted lipoprotein
J165_03882	COG0673	inositol 2-dehydrogenase activity
J165_03883	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
J165_03890	COG1051	belongs to the nudix hydrolase family
J165_03890	COG1056	cytidyltransferase-related domain
J165_03892	COG0583	DNA-binding transcription factor activity
J165_03895	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J165_03896	COG0321	lipoyl(octanoyl) transferase activity
J165_03897	COG2921	Belongs to the UPF0250 family
J165_03899	COG1686	Belongs to the peptidase S11 family
J165_03900	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J165_03901	COG2951	lytic endotransglycosylase activity
J165_03903	COG0772	Belongs to the SEDS family
J165_03906	COG1792	Involved in formation and maintenance of cell shape
J165_03907	COG1077	Cell shape determining protein MreB Mrl
J165_03909	COG3284	Transcriptional regulator
J165_03918	COG0308	aminopeptidase N
J165_03919	COG5001	Diguanylate cyclase
J165_03919	COG3300	MHYT domain
J165_03920	COG2226	methyltransferase
J165_03925	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
J165_03926	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
J165_03927	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
J165_03929	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J165_03931	COG2832	Protein of unknown function (DUF454)
J165_03934	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J165_03935	COG1505	serine-type exopeptidase activity
J165_03940	COG0181	hydroxymethylbilane synthase activity
J165_03942	COG3275	phosphorelay sensor kinase activity
J165_03944	COG2943	transferase activity, transferring hexosyl groups
J165_03947	COG3706	GGDEF domain
J165_03948	COG0659	secondary active sulfate transmembrane transporter activity
J165_03949	COG5297	Belongs to the glycosyl hydrolase family 6
J165_03949	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J165_03950	COG0840	transmembrane signaling receptor activity
J165_03951	COG5001	Diguanylate cyclase
J165_03958	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
J165_03960	COG0598	Magnesium transport protein CorA
J165_03962	COG1113	amino acid transport
J165_03967	COG0697	spore germination
J165_03972	COG3706	GGDEF domain
J165_03974	COG1506	peptidase
J165_03974	COG0823	Involved in the tonB-independent uptake of proteins
J165_03975	COG2409	Drug exporters of the RND superfamily
J165_03980	COG0435	Glutathione S-transferase
J165_03985	COG2003	Belongs to the UPF0758 family
J165_03990	COG0784	Response regulator, receiver
J165_03990	COG4191	Histidine kinase
J165_03997	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J165_03999	COG0529	Catalyzes the synthesis of activated sulfate
J165_03999	COG2895	sulfate adenylyltransferase (ATP) activity
J165_04000	COG0175	sulfate reduction
J165_04001	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J165_04002	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J165_04003	COG0175	sulfate reduction
J165_04010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J165_04010	COG1648	precorrin-2 dehydrogenase activity
J165_04013	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
J165_04014	COG3588	fructose-bisphosphate aldolase
J165_04015	COG0469	pyruvate kinase activity
J165_04017	COG0126	phosphoglycerate kinase activity
J165_04022	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J165_04024	COG3047	cAMP biosynthetic process
J165_04025	COG3047	cAMP biosynthetic process
J165_04027	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J165_04027	COG3453	Protein conserved in bacteria
J165_04028	COG0725	ABC transporter, periplasmic molybdate-binding protein
J165_04029	COG4149	molybdate abc transporter
J165_04030	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
J165_04037	COG1376	ErfK ybiS ycfS ynhG family protein
J165_04038	COG0739	heme binding
J165_04040	COG4773	Receptor
J165_04041	COG0596	Alpha beta hydrolase
J165_04042	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
J165_04043	COG1301	dicarboxylic acid transport
J165_04045	COG2304	oxidoreductase activity
J165_04049	COG0714	Associated with various cellular activities
J165_04056	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J165_04060	COG0254	rRNA binding
J165_04062	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J165_04064	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J165_04065	COG1758	RNA polymerase activity
J165_04066	COG0194	GDP metabolic process
J165_04067	COG1561	YicC-like family, N-terminal region
J165_04068	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J165_04070	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J165_04071	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J165_04074	COG0006	proline dipeptidase activity
J165_04076	COG0006	proline dipeptidase activity
J165_04077	COG3079	Belongs to the UPF0149 family
J165_04081	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J165_04083	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
J165_04085	COG2912	Transglutaminase-like superfamily
J165_04086	COG1773	rubredoxin
J165_04087	COG0352	thiamine-phosphate diphosphorylase activity
J165_04090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J165_04093	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J165_04099	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J165_04100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J165_04101	COG1028	Short-chain dehydrogenase reductase Sdr
J165_04103	COG0671	phosphoesterase, PA-phosphatase related
J165_04104	COG3781	membrane
J165_04106	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J165_04107	COG0563	adenylate kinase activity
J165_04110	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
J165_04112	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
J165_04116	COG3710	Transcriptional regulator
J165_04117	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
J165_04120	COG0840	transmembrane signaling receptor activity
J165_04121	COG0405	Gamma-glutamyltransferase
J165_04122	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J165_04126	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J165_04127	COG0473	3-isopropylmalate dehydrogenase activity
J165_04128	COG0066	3-isopropylmalate dehydratase activity
J165_04129	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J165_04133	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J165_04134	COG1538	Outer membrane efflux protein
J165_04135	COG1519	Transferase
J165_04136	COG1560	Kdo2-lipid A biosynthetic process
J165_04142	COG0280	phosphate acetyltransferase
J165_04142	COG0281	malic enzyme
J165_04143	COG1301	dicarboxylic acid transport
J165_04148	COG0583	DNA-binding transcription factor activity
J165_04149	COG0667	Aldo Keto reductase
J165_04153	COG2197	response regulator
J165_04154	COG1840	ABC-type Fe3 transport system, periplasmic component
J165_04155	COG0642	Histidine kinase
J165_04158	COG2851	Citrate transporter
J165_04160	COG1028	Short-chain dehydrogenase reductase Sdr
J165_04161	COG1609	Transcriptional regulator
J165_04162	COG2211	Major facilitator Superfamily
J165_04167	COG1162	GTPase activity
J165_04171	COG4773	Receptor
J165_04172	COG0726	polysaccharide deacetylase
J165_04173	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J165_04176	COG2963	transposase activity
J165_04177	COG2801	Transposase and inactivated derivatives
J165_04181	COG1307	EDD domain protein, DegV family
J165_04182	COG0242	peptide deformylase activity
J165_04186	COG0457	Tetratricopeptide repeat
J165_04187	COG0457	Tetratricopeptide repeat
J165_04188	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
J165_04189	COG1215	transferase activity, transferring glycosyl groups
J165_04190	COG1215	transferase activity, transferring glycosyl groups
J165_04193	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
J165_04202	COG2188	Transcriptional regulator
J165_04204	COG1450	Type ii and iii secretion system protein
J165_04207	COG3166	PFAM Fimbrial assembly family protein
J165_04208	COG3156	type II secretion system protein K
J165_04209	COG4795	General secretion pathway protein
J165_04210	COG2165	general secretion pathway protein
J165_04211	COG4970	Tfp pilus assembly protein FimT
J165_04212	COG2165	general secretion pathway protein
J165_04213	COG1459	type II secretion system
J165_04214	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J165_04215	COG1404	Belongs to the peptidase S8 family
J165_04216	COG5295	Hep Hag repeat protein
J165_04217	COG1404	Belongs to the peptidase S8 family
J165_04218	COG5295	Hep Hag repeat protein
J165_04219	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J165_04219	COG0047	phosphoribosylformylglycinamidine synthase activity
J165_04220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J165_04221	COG4974	Belongs to the 'phage' integrase family
J165_04224	COG0795	lipopolysaccharide-transporting ATPase activity
J165_04226	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J165_04229	COG0525	valine-tRNA ligase activity
J165_04235	COG1183	phosphatidylcholine synthase activity
J165_04237	COG0442	prolyl-tRNA aminoacylation
J165_04240	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J165_04241	COG1127	ABC transporter
J165_04242	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J165_04242	COG3218	ABC-type transport auxiliary lipoprotein component
J165_04249	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J165_04250	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
J165_04250	COG0662	Cupin 2, conserved barrel domain protein
J165_04256	COG2086	electron transfer activity
J165_04259	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J165_04259	COG0546	phosphoglycolate phosphatase activity
J165_04260	COG0277	FAD linked oxidase domain protein
J165_04261	COG0300	oxidoreductase activity
J165_04263	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J165_04267	COG2226	methyltransferase
J165_04269	COG3754	Rhamnan synthesis protein F
J165_04270	COG1216	Glycosyl transferase, family 2
J165_04270	COG0438	transferase activity, transferring glycosyl groups
J165_04271	COG0110	maltose O-acetyltransferase activity
J165_04274	COG0626	cystathionine gamma-synthase activity
J165_04280	COG0625	glutathione transferase activity
J165_04282	COG0513	Belongs to the DEAD box helicase family
J165_04284	COG4206	TonB-dependent receptor
J165_04285	COG0720	synthase
J165_04287	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
J165_04288	COG1956	GAF domain-containing protein
J165_04290	COG2819	hydrolase of the alpha beta superfamily
J165_04293	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J165_04294	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J165_04297	COG0339	signal peptide processing
J165_04300	COG2132	Multicopper oxidase
J165_04307	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J165_04308	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J165_04309	COG4591	ABC-type transport system involved in lipoprotein release permease component
J165_04309	COG1136	(ABC) transporter
J165_04310	COG0577	efflux transmembrane transporter activity
J165_04311	COG0577	efflux transmembrane transporter activity
J165_04313	COG2204	response regulator
J165_04314	COG4191	Histidine kinase
J165_04315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J165_04319	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J165_04320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J165_04321	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J165_04322	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J165_04323	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J165_04324	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J165_04326	COG0356	it plays a direct role in the translocation of protons across the membrane
J165_04330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J165_04332	COG0508	dehydrogenase complex catalyzes the overall conversion of
J165_04339	COG2011	ABC-type metal ion transport system permease component
J165_04340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J165_04341	COG0697	spore germination
J165_04342	COG1666	GTP binding
J165_04344	COG0784	Response regulator, receiver
J165_04344	COG2198	Histidine kinase
J165_04344	COG5002	protein histidine kinase activity
J165_04349	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J165_04350	COG1187	pseudouridine synthase activity
J165_04351	COG2813	Specifically methylates the guanine in position
J165_04355	COG2205	protein histidine kinase activity
J165_04355	COG2202	Pas domain
J165_04359	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J165_04360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J165_04361	COG1522	sequence-specific DNA binding
J165_04371	COG0842	Transport permease protein
J165_04372	COG1131	(ABC) transporter
J165_04373	COG0025	NhaP-type Na H and K H
J165_04374	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
J165_04375	COG1573	uracil-dna glycosylase
J165_04377	COG3384	dioxygenase
J165_04379	COG0583	DNA-binding transcription factor activity
J165_04381	COG0667	Aldo Keto reductase
J165_04383	COG3590	peptidase
J165_04387	COG0531	amino acid
J165_04390	COG2972	Histidine kinase
J165_04393	COG3685	Protein conserved in bacteria
J165_04394	COG3546	catalase activity
J165_04402	COG1271	oxidase subunit
J165_04403	COG1294	oxidase, subunit
J165_04406	COG1028	Short-chain dehydrogenase reductase Sdr
J165_04407	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J165_04411	COG1132	(ABC) transporter
J165_04414	COG1063	alcohol dehydrogenase
J165_04429	COG0251	oxidation-reduction process
J165_04432	COG0840	transmembrane signaling receptor activity
J165_04436	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J165_04445	COG0024	Methionine aminopeptidase
J165_04450	COG2963	transposase activity
J165_04455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J165_04460	COG4695	Portal protein
J165_04469	COG3179	chitinase
J165_04511	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J165_04512	COG1490	D-aminoacyl-tRNA deacylase activity
J165_04513	COG1560	Kdo2-lipid A biosynthetic process
J165_04522	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J165_04522	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J165_04523	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J165_04524	COG0242	peptide deformylase activity
J165_04525	COG1652	LysM domain
J165_04526	COG0758	DNA mediated transformation
J165_04530	COG1754	DNA topoisomerase type I activity
J165_04530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J165_04531	COG0009	L-threonylcarbamoyladenylate synthase
J165_04534	COG1028	Short-chain dehydrogenase reductase Sdr
J165_04536	COG0616	signal peptide processing
J165_04537	COG0534	Mate efflux family protein
J165_04541	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J165_04542	COG0625	glutathione transferase activity
J165_04545	COG1252	NADH dehydrogenase
J165_04546	COG2860	membrane
J165_04547	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J165_04548	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J165_04549	COG2201	protein-glutamate methylesterase activity
J165_04550	COG2177	Part of the ABC transporter FtsEX involved in
J165_04551	COG2884	Cell division ATP-binding protein ftsE
J165_04552	COG0513	Belongs to the DEAD box helicase family
J165_04553	COG3118	belongs to the thioredoxin family
J165_04554	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J165_04555	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
J165_04556	COG0583	DNA-binding transcription factor activity
J165_04566	COG1518	maintenance of DNA repeat elements
J165_04570	COG1652	LysM domain
J165_04571	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J165_04571	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J165_04572	COG1473	amidohydrolase
J165_04573	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J165_04574	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J165_04576	COG5383	Protein conserved in bacteria
J165_04584	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
J165_04585	COG3023	N-Acetylmuramoyl-L-alanine amidase
J165_04587	COG4948	Mandelate Racemase Muconate Lactonizing
J165_04589	COG0531	amino acid
J165_04592	COG4682	membrane
J165_04593	COG2133	pyrroloquinoline quinone binding
J165_04595	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J165_04596	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J165_04597	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J165_04598	COG1610	YqeY-like protein
J165_04599	COG1295	ribonuclease BN
J165_04600	COG0358	DNA primase activity
J165_04603	COG0109	protoheme IX farnesyltransferase activity
J165_04609	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
J165_04622	COG3135	benzoate transporter
J165_04626	COG0676	glucose-6-phosphate 1-epimerase activity
J165_04628	COG3012	SEC-C Motif Domain Protein
J165_04629	COG0730	response to heat
J165_04634	COG0302	gtp cyclohydrolase
J165_04637	COG1566	PFAM secretion protein HlyD family protein
J165_04639	COG1289	transmembrane transporter activity
J165_04640	COG0477	Major facilitator Superfamily
J165_04642	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J165_04646	COG4691	Plasmid stability protein
J165_04647	COG1487	ribonuclease activity
J165_04652	COG0564	pseudouridine synthase activity
J165_04654	COG2963	transposase activity
J165_04655	COG2801	Transposase and inactivated derivatives
J165_04658	COG0439	Biotin carboxylase
J165_04669	COG1074	ATP-dependent DNA helicase activity
J165_04670	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
J165_04672	COG1127	ABC transporter
J165_04673	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J165_04674	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J165_04677	COG2853	Lipoprotein
J165_04679	COG0386	Belongs to the glutathione peroxidase family
J165_04681	COG1322	Protein conserved in bacteria
J165_04682	COG0604	alcohol dehydrogenase
J165_04683	COG0583	DNA-binding transcription factor activity
J165_04685	COG0625	glutathione transferase activity
J165_04687	COG0531	amino acid
J165_04688	COG3537	Alpha-1,2-mannosidase
J165_04690	COG3706	GGDEF domain
J165_04691	COG3835	regulator
J165_04692	COG1929	Belongs to the glycerate kinase type-1 family
J165_04693	COG2271	Major facilitator Superfamily
J165_04696	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J165_04698	COG0861	Integral membrane protein TerC family
J165_04700	COG0584	glycerophosphoryl diester phosphodiesterase
J165_04703	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
J165_04704	COG0726	polysaccharide deacetylase
J165_04705	COG0706	membrane insertase activity
J165_04706	COG0594	ribonuclease P activity
J165_04707	COG0230	Belongs to the bacterial ribosomal protein bL34 family