locus-tag	class	description
HZS92_00002	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HZS92_00004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZS92_00005	COG0187	DNA topoisomerase II activity
HZS92_00007	COG0501	Belongs to the peptidase M48B family
HZS92_00013	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HZS92_00015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZS92_00024	COG0793	Belongs to the peptidase S41A family
HZS92_00025	COG4942	peptidase
HZS92_00027	COG2234	aminopeptidase activity
HZS92_00029	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZS92_00031	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZS92_00033	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZS92_00035	COG1064	alcohol dehydrogenase
HZS92_00037	COG0493	'glutamate synthase
HZS92_00038	COG0067	glutamate synthase
HZS92_00038	COG0069	glutamate synthase activity
HZS92_00038	COG0070	glutamate synthase
HZS92_00042	COG2366	antibiotic biosynthetic process
HZS92_00048	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HZS92_00051	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HZS92_00052	COG0297	glycogen (starch) synthase activity
HZS92_00052	COG0438	transferase activity, transferring glycosyl groups
HZS92_00056	COG0367	asparagine synthase
HZS92_00062	COG1132	(ABC) transporter
HZS92_00068	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HZS92_00087	COG1111	helicase
HZS92_00087	COG1205	dead DEAH box helicase
HZS92_00088	COG1272	protein, Hemolysin III
HZS92_00092	COG0300	oxidoreductase activity
HZS92_00093	COG1028	Short-chain dehydrogenase reductase Sdr
HZS92_00098	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZS92_00100	COG2963	transposase activity
HZS92_00111	COG3237	CsbD-like
HZS92_00120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZS92_00122	COG0477	Major facilitator Superfamily
HZS92_00129	COG0714	Associated with various cellular activities
HZS92_00135	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HZS92_00137	COG4772	TonB-dependent receptor
HZS92_00139	COG0662	Cupin 2, conserved barrel domain protein
HZS92_00140	COG1012	belongs to the aldehyde dehydrogenase family
HZS92_00145	COG1304	FMN binding
HZS92_00148	COG4585	Histidine kinase
HZS92_00149	COG2197	response regulator
HZS92_00153	COG3710	Transcriptional regulator
HZS92_00154	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HZS92_00171	COG2801	Transposase and inactivated derivatives
HZS92_00172	COG0366	Alpha amylase catalytic
HZS92_00173	COG0366	Alpha amylase catalytic
HZS92_00174	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HZS92_00178	COG0657	acetylesterase activity
HZS92_00178	COG2755	lipolytic protein G-D-S-L family
HZS92_00180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HZS92_00183	COG3507	Belongs to the glycosyl hydrolase 43 family
HZS92_00184	COG1609	Transcriptional regulator
HZS92_00186	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HZS92_00187	COG1028	Short-chain dehydrogenase reductase Sdr
HZS92_00189	COG2755	lipolytic protein G-D-S-L family
HZS92_00192	COG3186	Phenylalanine-4-hydroxylase
HZS92_00193	COG1522	sequence-specific DNA binding
HZS92_00195	COG1752	Esterase of the alpha-beta hydrolase superfamily
HZS92_00197	COG1119	ATPase activity
HZS92_00200	COG1125	glycine betaine transport
HZS92_00203	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HZS92_00207	COG1396	sequence-specific DNA binding
HZS92_00212	COG0489	protein tyrosine kinase activity
HZS92_00213	COG2062	phosphohistidine phosphatase, SixA
HZS92_00215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZS92_00224	COG1968	undecaprenyl-diphosphatase activity
HZS92_00226	COG0174	glutamine synthetase
HZS92_00227	COG0347	Belongs to the P(II) protein family
HZS92_00228	COG0004	ammonium transporteR
HZS92_00229	COG3852	Histidine kinase
HZS92_00230	COG2204	response regulator
HZS92_00231	COG2032	superoxide dismutase activity
HZS92_00232	COG2032	superoxide dismutase activity
HZS92_00234	COG0346	lactoylglutathione lyase activity
HZS92_00236	COG0183	Belongs to the thiolase family
HZS92_00243	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZS92_00244	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HZS92_00245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HZS92_00248	COG0028	Belongs to the TPP enzyme family
HZS92_00249	COG2205	protein histidine kinase activity
HZS92_00254	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HZS92_00257	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZS92_00259	COG0596	Alpha beta hydrolase
HZS92_00260	COG0727	PFAM Uncharacterised protein family (UPF0153)
HZS92_00261	COG0318	PFAM AMP-dependent synthetase and ligase
HZS92_00262	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZS92_00265	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZS92_00268	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HZS92_00270	COG0564	pseudouridine synthase activity
HZS92_00275	COG0339	signal peptide processing
HZS92_00281	COG0475	glutathione-regulated potassium exporter activity
HZS92_00282	COG0583	DNA-binding transcription factor activity
HZS92_00283	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HZS92_00284	COG2224	Isocitrate lyase
HZS92_00290	COG4770	biotin carboxylase activity
HZS92_00291	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZS92_00292	COG1960	acyl-CoA dehydrogenase activity
HZS92_00304	COG0523	cobalamin synthesis protein
HZS92_00306	COG0697	spore germination
HZS92_00308	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HZS92_00309	COG1846	Transcriptional regulator
HZS92_00310	COG1764	response to oxidative stress
HZS92_00316	COG2130	NADP-dependent
HZS92_00319	COG1187	pseudouridine synthase activity
HZS92_00322	COG1643	Atp-dependent helicase
HZS92_00324	COG4807	Protein conserved in bacteria
HZS92_00325	COG2351	hydroxyisourate hydrolase activity
HZS92_00326	COG2072	flavoprotein involved in K transport
HZS92_00330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HZS92_00337	COG1957	nucleoside hydrolase
HZS92_00339	COG2252	PERMEase
HZS92_00344	COG0084	hydrolase, TatD family'
HZS92_00347	COG0583	DNA-binding transcription factor activity
HZS92_00348	COG2814	Major facilitator Superfamily
HZS92_00351	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HZS92_00352	COG1902	pentaerythritol trinitrate reductase activity
HZS92_00356	COG0745	RESPONSE REGULATOR receiver
HZS92_00357	COG2205	protein histidine kinase activity
HZS92_00358	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS92_00362	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HZS92_00363	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HZS92_00364	COG0583	DNA-binding transcription factor activity
HZS92_00371	COG0702	epimerase
HZS92_00372	COG1733	regulation of RNA biosynthetic process
HZS92_00376	COG2801	Transposase and inactivated derivatives
HZS92_00379	COG0129	dihydroxy-acid dehydratase activity
HZS92_00382	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HZS92_00395	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HZS92_00396	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HZS92_00401	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HZS92_00402	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HZS92_00404	COG3485	protocatechuate 3,4-dioxygenase
HZS92_00405	COG3485	protocatechuate 3,4-dioxygenase
HZS92_00407	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZS92_00408	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZS92_00411	COG1414	Transcriptional regulator
HZS92_00413	COG0657	acetylesterase activity
HZS92_00415	COG0445	tRNA wobble uridine modification
HZS92_00417	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZS92_00423	COG2267	carboxylic ester hydrolase activity
HZS92_00425	COG0156	8-amino-7-oxononanoate synthase activity
HZS92_00426	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZS92_00427	COG1040	competence protein
HZS92_00428	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HZS92_00446	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZS92_00460	COG1511	domain protein
HZS92_00460	COG3264	Mechanosensitive ion channel
HZS92_00461	COG1368	sulfuric ester hydrolase activity
HZS92_00463	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HZS92_00464	COG2354	Protein conserved in bacteria
HZS92_00466	COG0297	glycogen (starch) synthase activity
HZS92_00467	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HZS92_00468	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HZS92_00473	COG0702	epimerase
HZS92_00474	COG1028	Short-chain dehydrogenase reductase Sdr
HZS92_00481	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZS92_00482	COG1028	Short-chain dehydrogenase reductase Sdr
HZS92_00485	COG0513	Belongs to the DEAD box helicase family
HZS92_00489	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HZS92_00491	COG3483	tryptophan 2,3-dioxygenase activity
HZS92_00492	COG3104	oligopeptide transport
HZS92_00496	COG2852	Protein conserved in bacteria
HZS92_00497	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HZS92_00501	COG1320	monovalent cation:proton antiporter activity
HZS92_00502	COG2212	antiporter activity
HZS92_00504	COG0651	ATP synthesis coupled electron transport
HZS92_00505	COG1006	Multisubunit Na H antiporter MnhC subunit
HZS92_00506	COG2111	Na H antiporter
HZS92_00506	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HZS92_00512	COG3179	chitinase
HZS92_00516	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HZS92_00517	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HZS92_00520	COG0456	acetyltransferase
HZS92_00521	COG1597	lipid kinase activity
HZS92_00528	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZS92_00529	COG0134	indole-3-glycerol-phosphate synthase activity
HZS92_00531	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZS92_00532	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HZS92_00534	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HZS92_00536	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HZS92_00539	COG1051	belongs to the nudix hydrolase family
HZS92_00547	COG0316	Belongs to the HesB IscA family
HZS92_00552	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HZS92_00555	COG2814	Major facilitator Superfamily
HZS92_00556	COG0583	DNA-binding transcription factor activity
HZS92_00557	COG2814	Major facilitator Superfamily
HZS92_00558	COG1289	transmembrane transporter activity
HZS92_00560	COG0151	Belongs to the GarS family
HZS92_00562	COG0138	bifunctional purine biosynthesis protein purh
HZS92_00563	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZS92_00564	COG2267	carboxylic ester hydrolase activity
HZS92_00565	COG0671	phosphoesterase, PA-phosphatase related
HZS92_00565	COG2453	phosphatase
HZS92_00570	COG4589	Belongs to the CDS family
HZS92_00571	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HZS92_00575	COG2264	protein methyltransferase activity
HZS92_00580	COG0439	Biotin carboxylase
HZS92_00582	COG0511	ligase activity, forming carbon-carbon bonds
HZS92_00583	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HZS92_00585	COG1324	tolerance protein
HZS92_00591	COG0300	oxidoreductase activity
HZS92_00592	COG2356	endonuclease I
HZS92_00595	COG0459	protein refolding
HZS92_00598	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HZS92_00601	COG3386	PFAM SMP-30 Gluconolaconase
HZS92_00603	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HZS92_00604	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HZS92_00608	COG0778	Nitroreductase
HZS92_00609	COG2353	YceI-like domain
HZS92_00615	COG3052	prosthetic group binding
HZS92_00620	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HZS92_00622	COG1802	Transcriptional regulator
HZS92_00632	COG2801	Transposase and inactivated derivatives
HZS92_00634	COG4221	oxidoreductase activity
HZS92_00637	COG4221	oxidoreductase activity
HZS92_00639	COG0435	Glutathione S-transferase
HZS92_00644	COG2409	Drug exporters of the RND superfamily
HZS92_00646	COG1506	peptidase
HZS92_00646	COG0823	Involved in the tonB-independent uptake of proteins
HZS92_00654	COG0697	spore germination
HZS92_00657	COG1113	amino acid transport
HZS92_00661	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HZS92_00670	COG5001	Diguanylate cyclase
HZS92_00671	COG0840	transmembrane signaling receptor activity
HZS92_00672	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZS92_00672	COG5297	Belongs to the glycosyl hydrolase family 6
HZS92_00673	COG0659	secondary active sulfate transmembrane transporter activity
HZS92_00678	COG2943	transferase activity, transferring hexosyl groups
HZS92_00680	COG3275	phosphorelay sensor kinase activity
HZS92_00682	COG0181	hydroxymethylbilane synthase activity
HZS92_00688	COG1505	serine-type exopeptidase activity
HZS92_00689	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HZS92_00690	COG0436	Aminotransferase
HZS92_00693	COG2832	Protein of unknown function (DUF454)
HZS92_00695	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HZS92_00697	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HZS92_00698	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HZS92_00699	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HZS92_00704	COG2226	methyltransferase
HZS92_00705	COG3300	MHYT domain
HZS92_00705	COG5001	Diguanylate cyclase
HZS92_00706	COG0308	aminopeptidase N
HZS92_00716	COG3284	Transcriptional regulator
HZS92_00717	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZS92_00718	COG1077	Cell shape determining protein MreB Mrl
HZS92_00719	COG1792	Involved in formation and maintenance of cell shape
HZS92_00722	COG0772	Belongs to the SEDS family
HZS92_00724	COG2951	lytic endotransglycosylase activity
HZS92_00725	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HZS92_00727	COG1686	Belongs to the peptidase S11 family
HZS92_00729	COG2921	Belongs to the UPF0250 family
HZS92_00730	COG0321	lipoyl(octanoyl) transferase activity
HZS92_00731	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HZS92_00734	COG0583	DNA-binding transcription factor activity
HZS92_00736	COG1051	belongs to the nudix hydrolase family
HZS92_00736	COG1056	cytidyltransferase-related domain
HZS92_00743	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HZS92_00744	COG0673	inositol 2-dehydrogenase activity
HZS92_00745	COG2823	Periplasmic or secreted lipoprotein
HZS92_00746	COG4251	negative regulation of phosphorylation
HZS92_00747	COG0784	Response regulator, receiver
HZS92_00748	COG4191	Histidine kinase
HZS92_00749	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HZS92_00761	COG1459	type II secretion system
HZS92_00774	COG2188	Transcriptional regulator
HZS92_00776	COG1609	Transcriptional regulator
HZS92_00777	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZS92_00778	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HZS92_00780	COG0617	tRNA 3'-terminal CCA addition
HZS92_00781	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HZS92_00782	COG1012	belongs to the aldehyde dehydrogenase family
HZS92_00783	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HZS92_00786	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HZS92_00789	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HZS92_00790	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HZS92_00794	COG2205	protein histidine kinase activity
HZS92_00800	COG3791	Glutathione-dependent formaldehyde-activating
HZS92_00803	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZS92_00805	COG0697	spore germination
HZS92_00807	COG0488	(ABC) transporter
HZS92_00809	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZS92_00810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HZS92_00812	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZS92_00812	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZS92_00816	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HZS92_00817	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZS92_00818	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HZS92_00823	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HZS92_00824	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HZS92_00825	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HZS92_00826	COG2205	protein histidine kinase activity
HZS92_00827	COG0745	RESPONSE REGULATOR receiver
HZS92_00830	COG0277	FAD linked oxidase domain protein
HZS92_00831	COG1988	membrane-bound metal-dependent
HZS92_00832	COG0792	nuclease activity
HZS92_00839	COG0275	rRNA processing
HZS92_00840	COG3116	cell division
HZS92_00842	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZS92_00843	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HZS92_00844	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZS92_00846	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZS92_00847	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZS92_00848	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZS92_00849	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HZS92_00852	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HZS92_00854	COG0739	heme binding
HZS92_00855	COG0653	protein targeting
HZS92_00856	COG0494	nUDIX hydrolase
HZS92_00858	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HZS92_00861	COG0604	alcohol dehydrogenase
HZS92_00861	COG3321	synthase
HZS92_00861	COG1028	Short-chain dehydrogenase reductase Sdr
HZS92_00867	COG0366	Alpha amylase catalytic
HZS92_00873	COG2226	methyltransferase
HZS92_00874	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HZS92_00877	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HZS92_00887	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HZS92_00889	COG4106	trans-aconitate 2-methyltransferase activity
HZS92_00890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZS92_00892	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZS92_00893	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HZS92_00895	COG0667	Aldo Keto reductase
HZS92_00897	COG4771	TonB-dependent receptor
HZS92_00901	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZS92_00902	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HZS92_00904	COG2175	clavaminate synthase activity
HZS92_00906	COG4181	ATPase activity
HZS92_00909	COG0642	Histidine kinase
HZS92_00912	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HZS92_00916	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HZS92_00917	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HZS92_00920	COG3829	transcription factor binding
HZS92_00922	COG1116	anion transmembrane transporter activity
HZS92_00923	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZS92_00925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZS92_00926	COG0431	NADPH-dependent FMN reductase
HZS92_00931	COG0747	negative chemotaxis
HZS92_00933	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZS92_00935	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HZS92_00936	COG2967	ApaG domain
HZS92_00937	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HZS92_00938	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HZS92_00939	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZS92_00940	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HZS92_00943	COG0123	including yeast histone deacetylase and acetoin utilization protein
HZS92_00944	COG2096	Adenosyltransferase
HZS92_00947	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZS92_00948	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZS92_00954	COG3384	dioxygenase
HZS92_00955	COG0583	DNA-binding transcription factor activity
HZS92_00958	COG1024	Enoyl-CoA hydratase
HZS92_00962	COG3386	PFAM SMP-30 Gluconolaconase
HZS92_00965	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HZS92_00969	COG0697	spore germination
HZS92_00971	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZS92_00975	COG0784	Response regulator, receiver
HZS92_00975	COG2205	protein histidine kinase activity
HZS92_00975	COG5002	protein histidine kinase activity
HZS92_00976	COG2197	response regulator
HZS92_00978	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZS92_00980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZS92_00981	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZS92_00983	COG0583	DNA-binding transcription factor activity
HZS92_00984	COG3634	alkyl hydroperoxide reductase activity
HZS92_00986	COG2890	protein-(glutamine-N5) methyltransferase activity
HZS92_00990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZS92_00990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZS92_00996	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HZS92_01002	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HZS92_01005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZS92_01006	COG1404	Belongs to the peptidase S8 family
HZS92_01007	COG1404	Belongs to the peptidase S8 family
HZS92_01008	COG1404	Belongs to the peptidase S8 family
HZS92_01009	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HZS92_01011	COG5520	Belongs to the glycosyl hydrolase 30 family
HZS92_01014	COG1295	ribonuclease BN
HZS92_01015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZS92_01016	COG1254	Belongs to the acylphosphatase family
HZS92_01019	COG0521	Mo-molybdopterin cofactor biosynthetic process
HZS92_01021	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HZS92_01022	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HZS92_01024	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HZS92_01025	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HZS92_01027	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HZS92_01028	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HZS92_01029	COG0193	aminoacyl-tRNA hydrolase activity
HZS92_01030	COG0012	GTP binding
HZS92_01034	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZS92_01037	COG0250	Participates in transcription elongation, termination and antitermination
HZS92_01038	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HZS92_01039	COG0081	regulation of translation
HZS92_01040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HZS92_01041	COG0222	ribosome binding
HZS92_01042	COG0085	RNA polymerase activity
HZS92_01043	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HZS92_01044	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HZS92_01045	COG0049	tRNA binding
HZS92_01046	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HZS92_01047	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZS92_01048	COG0051	transcription antitermination factor activity, RNA binding
HZS92_01049	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HZS92_01050	COG0088	Forms part of the polypeptide exit tunnel
HZS92_01051	COG0089	rRNA binding
HZS92_01052	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HZS92_01053	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HZS92_01055	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HZS92_01056	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HZS92_01057	COG0255	Belongs to the universal ribosomal protein uL29 family
HZS92_01058	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HZS92_01060	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HZS92_01061	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HZS92_01063	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HZS92_01064	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HZS92_01065	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HZS92_01067	COG1841	ribosomal large subunit assembly
HZS92_01068	COG0200	Binds to the 23S rRNA
HZS92_01069	COG0201	protein transport
HZS92_01074	COG0203	ribosomal protein L17
HZS92_01075	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HZS92_01079	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HZS92_01081	COG0154	amidase activity
HZS92_01083	COG1217	gtp-binding protein TYPA
HZS92_01084	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZS92_01085	COG0039	L-malate dehydrogenase activity
HZS92_01086	COG0625	glutathione transferase activity
HZS92_01090	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZS92_01090	COG1902	pentaerythritol trinitrate reductase activity
HZS92_01091	COG0604	alcohol dehydrogenase
HZS92_01097	COG0156	8-amino-7-oxononanoate synthase activity
HZS92_01098	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HZS92_01099	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HZS92_01100	COG4208	sulfate ABC transporter
HZS92_01101	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HZS92_01103	COG1063	alcohol dehydrogenase
HZS92_01109	COG0406	alpha-ribazole phosphatase activity
HZS92_01110	COG0285	dihydrofolate synthase activity
HZS92_01114	COG2833	Protein of unknown function (DUF455)
HZS92_01116	COG3291	Pkd domain containing protein
HZS92_01118	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZS92_01119	COG0671	phosphoesterase, PA-phosphatase related
HZS92_01120	COG0438	transferase activity, transferring glycosyl groups
HZS92_01122	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HZS92_01125	COG4783	chaperone-mediated protein folding
HZS92_01128	COG0473	3-isopropylmalate dehydrogenase activity
HZS92_01135	COG2801	Transposase and inactivated derivatives
HZS92_01136	COG2963	transposase activity
HZS92_01153	COG2801	Transposase and inactivated derivatives
HZS92_01156	COG3852	Histidine kinase
HZS92_01158	COG0544	peptidyl-prolyl cis-trans isomerase activity
HZS92_01160	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HZS92_01166	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZS92_01168	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZS92_01170	COG0328	RNA-DNA hybrid ribonuclease activity
HZS92_01171	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HZS92_01172	COG0631	protein serine/threonine phosphatase activity
HZS92_01175	COG0859	PFAM glycosyl transferase family 9
HZS92_01176	COG3642	lipopolysaccharide core region biosynthetic process
HZS92_01177	COG1234	tRNA 3'-trailer cleavage
HZS92_01178	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HZS92_01180	COG0315	cyclic pyranopterin monophosphate synthase activity
HZS92_01181	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HZS92_01182	COG0314	molybdopterin synthase activity
HZS92_01186	COG2801	Transposase and inactivated derivatives
HZS92_01193	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HZS92_01194	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HZS92_01195	COG0537	adenosine 5'-monophosphoramidase activity
HZS92_01199	COG0714	Associated with various cellular activities
HZS92_01204	COG0424	maF-like protein
HZS92_01205	COG1399	metal-binding, possibly nucleic acid-binding protein
HZS92_01206	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HZS92_01207	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZS92_01210	COG1028	Short-chain dehydrogenase reductase Sdr
HZS92_01213	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HZS92_01214	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HZS92_01219	COG3829	transcription factor binding
HZS92_01223	COG3609	addiction module antidote protein, CC2985 family
HZS92_01230	COG2373	Large extracellular alpha-helical protein
HZS92_01234	COG4953	penicillin-binding protein 1C
HZS92_01236	COG0678	peroxiredoxin activity
HZS92_01240	COG0330	HflC and HflK could
HZS92_01241	COG0330	HflC and HflK could
HZS92_01243	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HZS92_01244	COG0308	aminopeptidase N
HZS92_01245	COG1028	Short-chain dehydrogenase reductase Sdr
HZS92_01246	COG1309	transcriptional regulator
HZS92_01262	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HZS92_01264	COG3387	PFAM Glycoside hydrolase 15-related
HZS92_01265	COG1028	Short-chain dehydrogenase reductase Sdr
HZS92_01267	COG3537	Alpha-1,2-mannosidase
HZS92_01271	COG0492	ferredoxin-NADP+ reductase activity
HZS92_01276	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZS92_01277	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HZS92_01278	COG2080	2 iron, 2 sulfur cluster binding
HZS92_01285	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HZS92_01288	COG0587	DNA-directed DNA polymerase activity
HZS92_01292	COG1297	OPT oligopeptide transporter protein
HZS92_01295	COG0823	Involved in the tonB-independent uptake of proteins
HZS92_01295	COG1506	peptidase
HZS92_01298	COG1917	Cupin 2, conserved barrel domain protein
HZS92_01298	COG2207	Transcriptional regulator
HZS92_01302	COG0753	catalase activity
HZS92_01303	COG0656	L-ascorbic acid biosynthetic process
HZS92_01305	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZS92_01305	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZS92_01306	COG2814	Major facilitator Superfamily
HZS92_01309	COG2194	sulfuric ester hydrolase activity
HZS92_01312	COG0745	RESPONSE REGULATOR receiver
HZS92_01313	COG0642	Histidine kinase
HZS92_01315	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HZS92_01316	COG2894	cell division
HZS92_01317	COG0850	regulation of cytokinetic process
HZS92_01320	COG4585	Histidine kinase
HZS92_01321	COG2197	response regulator
HZS92_01324	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HZS92_01330	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HZS92_01332	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HZS92_01336	COG1946	Acyl-CoA thioesterase
HZS92_01339	COG0824	Thioesterase
HZS92_01340	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZS92_01341	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HZS92_01342	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HZS92_01343	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HZS92_01344	COG0268	Binds directly to 16S ribosomal RNA
HZS92_01346	COG0196	riboflavin kinase activity
HZS92_01347	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HZS92_01348	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HZS92_01349	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HZS92_01352	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZS92_01353	COG1845	cytochrome c oxidase, subunit III
HZS92_01354	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HZS92_01357	COG3152	Membrane
HZS92_01359	COG2207	Transcriptional regulator
HZS92_01360	COG0326	Molecular chaperone. Has ATPase activity
HZS92_01362	COG1366	Belongs to the anti-sigma-factor antagonist family
HZS92_01363	COG1366	Belongs to the anti-sigma-factor antagonist family
HZS92_01364	COG2172	sigma factor antagonist activity
HZS92_01369	COG4771	TonB-dependent receptor
HZS92_01371	COG5507	3-demethylubiquinone-9 3-methyltransferase
HZS92_01372	COG2205	protein histidine kinase activity
HZS92_01374	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HZS92_01375	COG4999	Histidine kinase
HZS92_01375	COG2205	protein histidine kinase activity
HZS92_01375	COG3437	response regulator, receiver
HZS92_01375	COG3850	Histidine kinase
HZS92_01376	COG0784	Response regulator, receiver
HZS92_01376	COG4191	Histidine kinase
HZS92_01381	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZS92_01383	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HZS92_01386	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZS92_01387	COG0228	four-way junction DNA binding
HZS92_01388	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HZS92_01389	COG0336	Belongs to the RNA methyltransferase TrmD family
HZS92_01390	COG0335	large ribosomal subunit rRNA binding
HZS92_01391	COG0534	Mate efflux family protein
HZS92_01395	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HZS92_01397	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HZS92_01399	COG3209	COG3209 Rhs family protein
HZS92_01404	COG3250	beta-galactosidase activity
HZS92_01405	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HZS92_01409	COG1960	acyl-CoA dehydrogenase activity
HZS92_01410	COG1024	Enoyl-CoA hydratase
HZS92_01414	COG1024	Enoyl-CoA hydratase
HZS92_01414	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZS92_01417	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZS92_01418	COG0481	GTPase activity
HZS92_01421	COG0571	ribonuclease III activity
HZS92_01422	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HZS92_01423	COG1381	Involved in DNA repair and RecF pathway recombination
HZS92_01425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZS92_01426	COG2954	triphosphatase activity
HZS92_01427	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HZS92_01428	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HZS92_01429	COG3046	protein related to deoxyribodipyrimidine photolyase
HZS92_01430	COG1472	Belongs to the glycosyl hydrolase 3 family
HZS92_01431	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HZS92_01432	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HZS92_01433	COG1278	Cold shock
HZS92_01434	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZS92_01436	COG1201	RNA secondary structure unwinding
HZS92_01437	COG1793	dna ligase
HZS92_01439	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HZS92_01439	COG1793	dna ligase
HZS92_01445	COG0183	Belongs to the thiolase family
HZS92_01450	COG1451	nucleotide metabolic process
HZS92_01451	COG5487	UPF0391 membrane protein
HZS92_01453	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HZS92_01456	COG1077	Cell shape determining protein MreB Mrl
HZS92_01457	COG1047	Peptidyl-prolyl cis-trans
HZS92_01459	COG2824	Alkylphosphonate utilization operon protein PhnA
HZS92_01461	COG1902	pentaerythritol trinitrate reductase activity
HZS92_01462	COG2814	Major facilitator Superfamily
HZS92_01468	COG0392	lysyltransferase activity
HZS92_01468	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HZS92_01470	COG0251	oxidation-reduction process
HZS92_01471	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZS92_01474	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZS92_01479	COG1595	DNA-templated transcription, initiation
HZS92_01483	COG2878	Part of a membrane complex involved in electron transport
HZS92_01485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZS92_01485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZS92_01488	COG1131	(ABC) transporter
HZS92_01489	COG0346	lactoylglutathione lyase activity
HZS92_01490	COG0833	amino acid
HZS92_01491	COG2040	homocysteine
HZS92_01493	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HZS92_01497	COG1695	Transcriptional regulator
HZS92_01501	COG1981	membrane
HZS92_01504	COG0825	malonyl-CoA metabolic process
HZS92_01506	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HZS92_01507	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZS92_01508	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZS92_01509	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZS92_01510	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZS92_01513	COG0750	zinc metalloprotease
HZS92_01514	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HZS92_01515	COG0575	Belongs to the CDS family
HZS92_01516	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HZS92_01517	COG0233	cytoplasmic translational termination
HZS92_01518	COG0528	UMP kinase activity
HZS92_01520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HZS92_01521	COG0052	Belongs to the universal ribosomal protein uS2 family
HZS92_01529	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HZS92_01531	COG1393	Belongs to the ArsC family
HZS92_01532	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZS92_01533	COG0367	asparagine synthase
HZS92_01535	COG4774	siderophore transport
HZS92_01538	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZS92_01545	COG1566	PFAM secretion protein HlyD family protein
HZS92_01546	COG2814	Major facilitator Superfamily
HZS92_01556	COG0339	signal peptide processing
HZS92_01558	COG0386	Belongs to the glutathione peroxidase family
HZS92_01569	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HZS92_01570	COG0084	hydrolase, TatD family'
HZS92_01573	COG1960	acyl-CoA dehydrogenase activity
HZS92_01577	COG0367	asparagine synthase
HZS92_01579	COG0305	Participates in initiation and elongation during chromosome replication
HZS92_01580	COG0415	Belongs to the DNA photolyase family
HZS92_01584	COG0583	DNA-binding transcription factor activity
HZS92_01593	COG3706	GGDEF domain
HZS92_01623	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HZS92_01626	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZS92_01628	COG0497	DNA recombination
HZS92_01629	COG1420	regulation of RNA biosynthetic process
HZS92_01630	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HZS92_01631	COG0443	Heat shock 70 kDa protein
HZS92_01632	COG0484	heat shock protein binding
HZS92_01634	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HZS92_01640	COG0583	DNA-binding transcription factor activity
HZS92_01641	COG1132	(ABC) transporter
HZS92_01648	COG2850	peptidyl-arginine hydroxylation
HZS92_01652	COG1253	flavin adenine dinucleotide binding
HZS92_01658	COG1131	(ABC) transporter
HZS92_01659	COG1725	Transcriptional regulator
HZS92_01661	COG0386	Belongs to the glutathione peroxidase family
HZS92_01664	COG2900	Belongs to the SlyX family
HZS92_01669	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZS92_01671	COG1410	methionine synthase
HZS92_01671	COG0646	methionine synthase
HZS92_01672	COG0646	methionine synthase
HZS92_01672	COG1410	methionine synthase
HZS92_01673	COG2226	methyltransferase
HZS92_01674	COG1960	acyl-CoA dehydrogenase activity
HZS92_01675	COG1960	acyl-CoA dehydrogenase activity
HZS92_01679	COG0557	exoribonuclease II activity
HZS92_01681	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZS92_01683	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HZS92_01685	COG0704	Plays a role in the regulation of phosphate uptake
HZS92_01686	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZS92_01687	COG0581	inorganic phosphate transmembrane transporter activity
HZS92_01688	COG0573	inorganic phosphate transmembrane transporter activity
HZS92_01689	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HZS92_01694	COG0659	secondary active sulfate transmembrane transporter activity
HZS92_01695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HZS92_01697	COG1024	Enoyl-CoA hydratase
HZS92_01699	COG0494	nUDIX hydrolase
HZS92_01706	COG0488	(ABC) transporter
HZS92_01708	COG0116	Belongs to the methyltransferase superfamily
HZS92_01708	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HZS92_01709	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZS92_01714	COG2925	Exonuclease
HZS92_01716	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZS92_01717	COG3844	kynureninase activity
HZS92_01719	COG0662	Cupin 2, conserved barrel domain protein
HZS92_01720	COG0288	reversible hydration of carbon dioxide
HZS92_01733	COG2808	Putative FMN-binding domain
HZS92_01737	COG0017	Asparaginyl-tRNA synthetase
HZS92_01739	COG0316	Belongs to the HesB IscA family
HZS92_01740	COG0360	Binds together with S18 to 16S ribosomal RNA
HZS92_01741	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HZS92_01742	COG0359	binds to the 23S rRNA
HZS92_01744	COG3115	cell septum assembly
HZS92_01746	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZS92_01747	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HZS92_01748	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HZS92_01751	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HZS92_01753	COG4993	Dehydrogenase
HZS92_01756	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HZS92_01758	COG2986	histidine ammonia-lyase
HZS92_01759	COG1228	amidohydrolase
HZS92_01769	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HZS92_01770	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HZS92_01771	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HZS92_01772	COG0077	Prephenate dehydratase
HZS92_01772	COG1605	Chorismate mutase
HZS92_01773	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HZS92_01776	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HZS92_01777	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HZS92_01778	COG0583	DNA-binding transcription factor activity
HZS92_01781	COG0840	transmembrane signaling receptor activity
HZS92_01788	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HZS92_01789	COG4191	Histidine kinase
HZS92_01789	COG0784	Response regulator, receiver
HZS92_01792	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZS92_01794	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HZS92_01796	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZS92_01799	COG1595	DNA-templated transcription, initiation
HZS92_01810	COG2244	polysaccharide biosynthetic process
HZS92_01817	COG2264	protein methyltransferase activity
HZS92_01819	COG0438	transferase activity, transferring glycosyl groups
HZS92_01822	COG1136	(ABC) transporter
HZS92_01824	COG0477	Major facilitator Superfamily
HZS92_01825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZS92_01828	COG1253	flavin adenine dinucleotide binding
HZS92_01831	COG0306	phosphate transporter
HZS92_01837	COG0504	CTP synthase activity
HZS92_01838	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HZS92_01840	COG0148	phosphopyruvate hydratase activity
HZS92_01841	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HZS92_01842	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HZS92_01843	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HZS92_01844	COG0585	pseudouridine synthase activity
HZS92_01845	COG2840	Smr protein MutS2
HZS92_01846	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HZS92_01847	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HZS92_01848	COG1238	metal cluster binding
HZS92_01851	COG1534	Rna-binding protein
HZS92_01852	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HZS92_01854	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HZS92_01855	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HZS92_01857	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HZS92_01858	COG1546	Belongs to the CinA family
HZS92_01860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HZS92_01861	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HZS92_01863	COG2137	regulation of response to DNA damage stimulus
HZS92_01864	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HZS92_01865	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HZS92_01869	COG1741	Belongs to the pirin family
HZS92_01870	COG0583	DNA-binding transcription factor activity
HZS92_01875	COG0351	phosphomethylpyrimidine kinase
HZS92_01875	COG0352	thiamine-phosphate diphosphorylase activity
HZS92_01878	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HZS92_01879	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HZS92_01882	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZS92_01884	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HZS92_01885	COG3734	2-keto-3-deoxy-galactonokinase
HZS92_01887	COG4948	Mandelate Racemase Muconate Lactonizing
HZS92_01888	COG0800	Aldolase
HZS92_01896	COG1501	Belongs to the glycosyl hydrolase 31 family
HZS92_01898	COG1070	Carbohydrate kinase
HZS92_01899	COG2115	Belongs to the xylose isomerase family
HZS92_01900	COG0477	Major facilitator Superfamily
HZS92_01904	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZS92_01905	COG1469	GTP cyclohydrolase I activity
HZS92_01909	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HZS92_01910	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HZS92_01911	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HZS92_01912	COG0166	Belongs to the GPI family
HZS92_01917	COG1472	Belongs to the glycosyl hydrolase 3 family
HZS92_01920	COG3706	GGDEF domain
HZS92_01920	COG5001	Diguanylate cyclase
HZS92_01920	COG2203	Gaf domain
HZS92_01920	COG4251	negative regulation of phosphorylation
HZS92_01921	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZS92_01922	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HZS92_01924	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HZS92_01925	COG0671	phosphoesterase, PA-phosphatase related
HZS92_01928	COG1794	racemase activity, acting on amino acids and derivatives
HZS92_01930	COG0697	spore germination
HZS92_01931	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HZS92_01932	COG0167	dihydroorotate dehydrogenase activity
HZS92_01936	COG1012	belongs to the aldehyde dehydrogenase family
HZS92_01939	COG1215	transferase activity, transferring glycosyl groups
HZS92_01940	COG0726	polysaccharide deacetylase
HZS92_01940	COG1649	PFAM Uncharacterised BCR, COG1649
HZS92_01943	COG3210	domain, Protein
HZS92_01945	COG3210	domain, Protein
HZS92_01955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZS92_01956	COG0124	histidyl-tRNA synthetase
HZS92_01958	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HZS92_01959	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HZS92_01960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZS92_01961	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HZS92_01961	COG0131	Imidazoleglycerol-phosphate dehydratase
HZS92_01962	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HZS92_01963	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HZS92_01964	COG0107	imidazoleglycerol-phosphate synthase activity
HZS92_01965	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HZS92_01965	COG0140	phosphoribosyl-ATP diphosphatase activity
HZS92_01968	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HZS92_01969	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HZS92_01970	COG0235	Class ii aldolase
HZS92_01971	COG0531	amino acid
HZS92_01972	COG0531	amino acid
HZS92_01974	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZS92_01975	COG0277	FAD linked oxidase domain protein
HZS92_01979	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HZS92_01988	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZS92_01989	COG2258	MOSC domain
HZS92_01990	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HZS92_01991	COG0505	Belongs to the CarA family
HZS92_01993	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HZS92_01994	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZS92_01996	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HZS92_02004	COG3279	Response regulator of the LytR AlgR family
HZS92_02005	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HZS92_02006	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HZS92_02008	COG2205	protein histidine kinase activity
HZS92_02008	COG0784	Response regulator, receiver
HZS92_02008	COG2198	Histidine kinase
HZS92_02009	COG1024	Enoyl-CoA hydratase
HZS92_02010	COG0318	PFAM AMP-dependent synthetase and ligase
HZS92_02016	COG2267	carboxylic ester hydrolase activity
HZS92_02018	COG2201	protein-glutamate methylesterase activity
HZS92_02019	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HZS92_02021	COG0840	transmembrane signaling receptor activity
HZS92_02023	COG0835	chemotaxis
HZS92_02026	COG0840	transmembrane signaling receptor activity
HZS92_02028	COG0840	transmembrane signaling receptor activity
HZS92_02029	COG0840	transmembrane signaling receptor activity
HZS92_02032	COG0840	transmembrane signaling receptor activity
HZS92_02035	COG0840	transmembrane signaling receptor activity
HZS92_02036	COG0643	Histidine kinase
HZS92_02036	COG2198	Histidine kinase
HZS92_02037	COG0745	RESPONSE REGULATOR receiver
HZS92_02039	COG0835	chemotaxis
HZS92_02041	COG1360	Flagellar Motor Protein
HZS92_02042	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HZS92_02057	COG2801	Transposase and inactivated derivatives
HZS92_02064	COG0641	radical SAM
HZS92_02068	COG0643	Histidine kinase
HZS92_02068	COG0784	Response regulator, receiver
HZS92_02068	COG2198	Histidine kinase
HZS92_02074	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZS92_02080	COG1684	flagellar biosynthetic protein fliR
HZS92_02084	COG3190	flagellar
HZS92_02094	COG1677	Flagellar hook-basal body complex protein FliE
HZS92_02100	COG1028	Short-chain dehydrogenase reductase Sdr
HZS92_02101	COG1028	Short-chain dehydrogenase reductase Sdr
HZS92_02102	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZS92_02106	COG2201	protein-glutamate methylesterase activity
HZS92_02112	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HZS92_02114	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZS92_02115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZS92_02117	COG1705	Flagellar rod assembly protein muramidase FlgJ
HZS92_02117	COG3951	Flagellar rod assembly protein muramidase FlgJ
HZS92_02118	COG1706	bacterial-type flagellum-dependent cell motility
HZS92_02119	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HZS92_02121	COG4787	bacterial-type flagellum-dependent cell motility
HZS92_02123	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HZS92_02124	COG1558	bacterial-type flagellum-dependent cell motility
HZS92_02126	COG0784	Response regulator, receiver
HZS92_02126	COG0835	chemotaxis
HZS92_02130	COG5002	protein histidine kinase activity
HZS92_02136	COG2915	High frequency lysogenization protein hflD homolog
HZS92_02137	COG0482	sulfurtransferase activity
HZS92_02140	COG0542	response to heat
HZS92_02142	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HZS92_02144	COG0492	ferredoxin-NADP+ reductase activity
HZS92_02145	COG1674	ftsk spoiiie
HZS92_02147	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HZS92_02149	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HZS92_02150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HZS92_02152	COG0183	Belongs to the thiolase family
HZS92_02153	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZS92_02153	COG1024	Enoyl-CoA hydratase
HZS92_02156	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HZS92_02158	COG1426	Protein conserved in bacteria
HZS92_02160	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZS92_02161	COG1160	GTP binding
HZS92_02162	COG0303	'Molybdopterin
HZS92_02163	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HZS92_02171	COG0708	Exodeoxyribonuclease III
HZS92_02173	COG0303	'Molybdopterin
HZS92_02174	COG0746	molybdenum cofactor guanylyltransferase activity
HZS92_02177	COG1914	H( )-stimulated, divalent metal cation uptake system
HZS92_02180	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HZS92_02181	COG0668	transmembrane transport
HZS92_02183	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HZS92_02186	COG1028	Short-chain dehydrogenase reductase Sdr
HZS92_02187	COG1183	phosphatidylcholine synthase activity
HZS92_02189	COG3243	poly(R)-hydroxyalkanoic acid synthase
HZS92_02192	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZS92_02192	COG0723	plastoquinol--plastocyanin reductase activity
HZS92_02194	COG2183	response to ionizing radiation
HZS92_02195	COG2205	protein histidine kinase activity
HZS92_02195	COG0784	Response regulator, receiver
HZS92_02211	COG0800	Aldolase
HZS92_02212	COG0129	dihydroxy-acid dehydratase activity
HZS92_02213	COG0363	glucosamine-6-phosphate deaminase activity
HZS92_02214	COG0837	glucose binding
HZS92_02215	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HZS92_02220	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HZS92_02223	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HZS92_02224	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HZS92_02226	COG4591	ABC-type transport system involved in lipoprotein release permease component
HZS92_02227	COG1136	(ABC) transporter
HZS92_02230	COG0811	peptide transport
HZS92_02232	COG1132	(ABC) transporter
HZS92_02233	COG1663	tetraacyldisaccharide 4'-kinase activity
HZS92_02234	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HZS92_02235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZS92_02237	COG0322	excinuclease ABC activity
HZS92_02238	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZS92_02243	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZS92_02244	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZS92_02250	COG2801	Transposase and inactivated derivatives
HZS92_02251	COG2963	transposase activity
HZS92_02252	COG0582	viral genome integration into host DNA
HZS92_02254	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HZS92_02258	COG1054	Belongs to the UPF0176 family
HZS92_02260	COG1530	ribonuclease E activity
HZS92_02262	COG3064	Membrane
HZS92_02263	COG0428	transporter
HZS92_02265	COG2154	pterin-4-alpha-carbinolamine dehydratase
HZS92_02266	COG0316	Belongs to the HesB IscA family
HZS92_02266	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HZS92_02275	COG1073	alpha beta
HZS92_02275	COG2226	methyltransferase
HZS92_02277	COG1028	Short-chain dehydrogenase reductase Sdr
HZS92_02282	COG2801	Transposase and inactivated derivatives
HZS92_02284	COG1238	metal cluster binding
HZS92_02291	COG3279	Response regulator of the LytR AlgR family
HZS92_02300	COG4566	intracellular signal transduction
HZS92_02302	COG5001	Diguanylate cyclase
HZS92_02306	COG3685	Protein conserved in bacteria
HZS92_02311	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HZS92_02311	COG1648	precorrin-2 dehydrogenase activity
HZS92_02314	COG2814	Major facilitator Superfamily
HZS92_02317	COG1335	isochorismatase
HZS92_02320	COG2197	response regulator
HZS92_02324	COG0583	DNA-binding transcription factor activity
HZS92_02325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HZS92_02326	COG3002	Belongs to the UPF0753 family
HZS92_02327	COG2801	Transposase and inactivated derivatives
HZS92_02328	COG1396	sequence-specific DNA binding
HZS92_02329	COG5489	Protein of unknown function (DUF736)
HZS92_02330	COG2003	Belongs to the UPF0758 family
HZS92_02336	COG0582	viral genome integration into host DNA
HZS92_02339	COG4774	siderophore transport
HZS92_02343	COG2336	PFAM SpoVT AbrB
HZS92_02348	COG4206	TonB-dependent receptor
HZS92_02352	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HZS92_02352	COG2273	Hydrolase Family 16
HZS92_02356	COG2274	protein secretion by the type I secretion system
HZS92_02367	COG0270	DNA (cytosine-5-)-methyltransferase activity
HZS92_02377	COG4804	nuclease activity
HZS92_02379	COG2801	Transposase and inactivated derivatives
HZS92_02380	COG5006	permease, DMT superfamily
HZS92_02383	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZS92_02385	COG3938	Belongs to the proline racemase family
HZS92_02388	COG2807	transmembrane transport
HZS92_02389	COG2207	Transcriptional regulator
HZS92_02418	COG0210	DNA helicase
HZS92_02434	COG2084	Dehydrogenase
HZS92_02438	COG2003	Belongs to the UPF0758 family
HZS92_02445	COG0582	viral genome integration into host DNA
HZS92_02447	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HZS92_02447	COG0519	Catalyzes the synthesis of GMP from XMP
HZS92_02449	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HZS92_02451	COG0475	glutathione-regulated potassium exporter activity
HZS92_02451	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZS92_02453	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HZS92_02455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZS92_02456	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HZS92_02458	COG0776	regulation of translation
HZS92_02459	COG0539	negative regulation of cytoplasmic translation
HZS92_02460	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HZS92_02464	COG2957	Belongs to the agmatine deiminase family
HZS92_02465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZS92_02470	COG0395	ABC-type sugar transport system, permease component
HZS92_02471	COG1175	transmembrane transport
HZS92_02477	COG2350	Protein conserved in bacteria
HZS92_02478	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HZS92_02479	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HZS92_02480	COG1187	pseudouridine synthase activity
HZS92_02484	COG0436	Aminotransferase
HZS92_02485	COG4133	protoheme IX ABC transporter activity
HZS92_02489	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HZS92_02490	COG1138	Cytochrome C-type biogenesis protein
HZS92_02494	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZS92_02495	COG1278	Cold shock
HZS92_02496	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HZS92_02497	COG4988	ABC transporter
HZS92_02499	COG1294	oxidase, subunit
HZS92_02505	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HZS92_02506	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HZS92_02508	COG0165	Argininosuccinate lyase
HZS92_02509	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HZS92_02511	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HZS92_02512	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZS92_02514	COG0137	argininosuccinate synthase activity
HZS92_02515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZS92_02517	COG0215	cysteine-tRNA ligase activity
HZS92_02518	COG2166	iron-sulfur cluster assembly
HZS92_02521	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HZS92_02522	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZS92_02528	COG4302	ethanolamine ammonia-lyase activity
HZS92_02541	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZS92_02542	COG0402	S-adenosylhomocysteine deaminase activity
HZS92_02544	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HZS92_02545	COG1509	lysine 2,3-aminomutase activity
HZS92_02546	COG5001	Diguanylate cyclase
HZS92_02546	COG3300	MHYT domain
HZS92_02549	COG0483	inositol monophosphate 1-phosphatase activity
HZS92_02550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HZS92_02554	COG0488	(ABC) transporter
HZS92_02555	COG0513	Belongs to the DEAD box helicase family
HZS92_02556	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZS92_02557	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HZS92_02559	COG0625	glutathione transferase activity
HZS92_02561	COG4681	YaeQ
HZS92_02562	COG2081	HI0933 family
HZS92_02564	COG0501	Belongs to the peptidase M48B family
HZS92_02565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZS92_02566	COG1028	Short-chain dehydrogenase reductase Sdr
HZS92_02571	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HZS92_02572	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZS92_02573	COG0802	atpase or kinase
HZS92_02574	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HZS92_02574	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HZS92_02575	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HZS92_02576	COG1570	exodeoxyribonuclease VII activity
HZS92_02578	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HZS92_02615	COG0835	chemotaxis
HZS92_02616	COG0840	transmembrane signaling receptor activity
HZS92_02617	COG2094	Belongs to the DNA glycosylase MPG family
HZS92_02618	COG1201	RNA secondary structure unwinding
HZS92_02622	COG2969	positive regulation of protein catabolic process
HZS92_02623	COG0625	glutathione transferase activity
HZS92_02624	COG2857	Cytochrome c1
HZS92_02625	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HZS92_02626	COG0723	plastoquinol--plastocyanin reductase activity
HZS92_02628	COG0741	lytic transglycosylase activity
HZS92_02631	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZS92_02633	COG1702	phosphate starvation-inducible protein PhoH
HZS92_02635	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HZS92_02637	COG4535	Mg2 and Co2 transporter CorC
HZS92_02640	COG1012	belongs to the aldehyde dehydrogenase family
HZS92_02641	COG1177	transmembrane transport
HZS92_02642	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZS92_02643	COG3842	ATPase activity
HZS92_02647	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HZS92_02650	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HZS92_02651	COG0174	glutamine synthetase
HZS92_02652	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZS92_02654	COG2703	oxygen carrier activity
HZS92_02655	COG0477	Major facilitator Superfamily
HZS92_02657	COG0243	molybdopterin cofactor binding
HZS92_02658	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HZS92_02659	COG2223	nitrite transmembrane transporter activity
HZS92_02662	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZS92_02664	COG2733	membrane
HZS92_02665	COG2205	protein histidine kinase activity
HZS92_02665	COG0784	Response regulator, receiver
HZS92_02665	COG5002	protein histidine kinase activity
HZS92_02667	COG0477	Major facilitator Superfamily
HZS92_02669	COG2902	Dehydrogenase
HZS92_02671	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS92_02672	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZS92_02673	COG1609	Transcriptional regulator
HZS92_02674	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZS92_02674	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZS92_02675	COG1105	Belongs to the carbohydrate kinase PfkB family
HZS92_02676	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZS92_02676	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZS92_02686	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZS92_02688	COG1862	Preprotein translocase
HZS92_02689	COG0343	queuine tRNA-ribosyltransferase activity
HZS92_02690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HZS92_02698	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HZS92_02699	COG3291	Pkd domain containing protein
HZS92_02700	COG0405	Gamma-glutamyltransferase
HZS92_02701	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZS92_02704	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HZS92_02705	COG0742	ribosomal rna small subunit methyltransferase
HZS92_02706	COG0326	Molecular chaperone. Has ATPase activity
HZS92_02724	COG0531	amino acid
HZS92_02727	COG0006	proline dipeptidase activity
HZS92_02729	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZS92_02732	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZS92_02733	COG3938	Belongs to the proline racemase family
HZS92_02735	COG0552	protein localization to endoplasmic reticulum
HZS92_02737	COG1194	a g-specific adenine glycosylase
HZS92_02738	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HZS92_02739	COG4191	Histidine kinase
HZS92_02739	COG0784	Response regulator, receiver
HZS92_02742	COG0322	excinuclease ABC activity
HZS92_02745	COG3040	lipid binding
HZS92_02748	COG1960	acyl-CoA dehydrogenase activity
HZS92_02750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZS92_02754	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZS92_02755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZS92_02756	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZS92_02761	COG0438	transferase activity, transferring glycosyl groups
HZS92_02763	COG0438	transferase activity, transferring glycosyl groups
HZS92_02764	COG0438	transferase activity, transferring glycosyl groups
HZS92_02774	COG0072	phenylalanine-tRNA ligase activity
HZS92_02774	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZS92_02775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HZS92_02778	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HZS92_02779	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZS92_02784	COG1082	Xylose isomerase domain protein TIM barrel
HZS92_02787	COG0366	Alpha amylase catalytic
HZS92_02788	COG2801	Transposase and inactivated derivatives
HZS92_02799	COG3702	type iv secretory pathway
HZS92_02803	COG2948	multi-organism process
HZS92_02807	COG3505	Type IV secretory pathway VirD4
HZS92_02810	COG0556	nucleotide-excision repair
HZS92_02821	COG2801	Transposase and inactivated derivatives
HZS92_02828	COG4695	Portal protein
HZS92_02837	COG3179	chitinase
HZS92_02848	COG2801	Transposase and inactivated derivatives
HZS92_02849	COG2963	transposase activity
HZS92_02856	COG3275	phosphorelay sensor kinase activity
HZS92_02857	COG1611	Belongs to the LOG family
HZS92_02860	COG2095	MarC family integral membrane protein
HZS92_02862	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HZS92_02869	COG1185	polyribonucleotide nucleotidyltransferase activity
HZS92_02870	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HZS92_02871	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HZS92_02872	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HZS92_02873	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HZS92_02874	COG0195	Participates in both transcription termination and antitermination
HZS92_02875	COG0779	Required for maturation of 30S ribosomal subunits
HZS92_02877	COG1007	ATP synthesis coupled electron transport
HZS92_02882	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZS92_02883	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HZS92_02885	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HZS92_02886	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HZS92_02887	COG0649	NAD binding
HZS92_02888	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZS92_02889	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZS92_02890	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZS92_02893	COG0149	triose-phosphate isomerase activity
HZS92_02894	COG0300	oxidoreductase activity
HZS92_02900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZS92_02901	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HZS92_02902	COG0159	tryptophan synthase activity
HZS92_02904	COG0133	tryptophan synthase activity
HZS92_02906	COG0135	phosphoribosylanthranilate isomerase activity
HZS92_02907	COG0101	tRNA pseudouridine synthase activity
HZS92_02911	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HZS92_02912	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZS92_02913	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HZS92_02914	COG2890	protein-(glutamine-N5) methyltransferase activity
HZS92_02916	COG0688	phosphatidylethanolamine metabolic process
HZS92_02919	COG0433	COG0433 Predicted ATPase
HZS92_02920	COG0494	nUDIX hydrolase
HZS92_02924	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZS92_02925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZS92_02930	COG0717	Belongs to the dCTP deaminase family
HZS92_02932	COG0489	protein tyrosine kinase activity
HZS92_02936	COG3590	peptidase
HZS92_02938	COG3590	peptidase
HZS92_02942	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZS92_02943	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZS92_02944	COG2311	Membrane
HZS92_02945	COG1047	Peptidyl-prolyl cis-trans
HZS92_02946	COG0791	NLP P60 protein
HZS92_02947	COG0791	NLP P60 protein
HZS92_02949	COG4106	trans-aconitate 2-methyltransferase activity
HZS92_02950	COG1301	dicarboxylic acid transport
HZS92_02951	COG1785	Belongs to the alkaline phosphatase family
HZS92_02953	COG0037	tRNA processing
HZS92_02954	COG1722	exodeoxyribonuclease VII activity
HZS92_02955	COG0142	geranyltranstransferase activity
HZS92_02956	COG4104	PAAR repeat-containing protein
HZS92_02958	COG0312	modulator of DNA gyrase
HZS92_02959	COG3028	Belongs to the UPF0307 family
HZS92_02960	COG0312	modulator of DNA gyrase
HZS92_02962	COG3164	Protein of unknown function
HZS92_02964	COG0424	maF-like protein
HZS92_02965	COG2968	Membrane
HZS92_02972	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HZS92_02975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HZS92_02978	COG0495	leucyl-tRNA aminoacylation
HZS92_02980	COG3118	belongs to the thioredoxin family
HZS92_02985	COG2155	Conserved Protein
HZS92_02994	COG1132	(ABC) transporter
HZS92_03000	COG1538	Outer membrane efflux protein
HZS92_03001	COG0745	RESPONSE REGULATOR receiver
HZS92_03002	COG5000	phosphorelay sensor kinase activity
HZS92_03002	COG5002	protein histidine kinase activity
HZS92_03003	COG0475	glutathione-regulated potassium exporter activity
HZS92_03005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HZS92_03010	COG1187	pseudouridine synthase activity
HZS92_03011	COG5001	Diguanylate cyclase
HZS92_03011	COG5002	protein histidine kinase activity
HZS92_03035	COG0667	Aldo Keto reductase
HZS92_03037	COG2814	Major facilitator Superfamily
HZS92_03038	COG0583	DNA-binding transcription factor activity
HZS92_03040	COG2207	Transcriptional regulator
HZS92_03042	COG1309	transcriptional regulator
HZS92_03047	COG0735	belongs to the Fur family
HZS92_03048	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZS92_03053	COG4452	Inner membrane protein CreD
HZS92_03056	COG2205	protein histidine kinase activity
HZS92_03057	COG0745	RESPONSE REGULATOR receiver
HZS92_03058	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HZS92_03060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HZS92_03068	COG0643	Histidine kinase
HZS92_03068	COG2198	Histidine kinase
HZS92_03070	COG0840	transmembrane signaling receptor activity
HZS92_03071	COG0835	chemotaxis
HZS92_03072	COG2202	Pas domain
HZS92_03072	COG2199	diguanylate cyclase activity
HZS92_03072	COG2200	EAL domain
HZS92_03073	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HZS92_03074	COG2201	protein-glutamate methylesterase activity
HZS92_03075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZS92_03076	COG3590	peptidase
HZS92_03078	COG0588	phosphoglycerate mutase activity
HZS92_03079	COG1515	deoxyribonuclease V activity
HZS92_03081	COG1741	Belongs to the pirin family
HZS92_03084	COG1741	Belongs to the pirin family
HZS92_03085	COG1966	Carbon starvation protein
HZS92_03086	COG2879	small protein
HZS92_03096	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZS92_03097	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HZS92_03098	COG2080	2 iron, 2 sulfur cluster binding
HZS92_03100	COG5001	Diguanylate cyclase
HZS92_03100	COG4251	negative regulation of phosphorylation
HZS92_03100	COG3706	GGDEF domain
HZS92_03100	COG2203	Gaf domain
HZS92_03101	COG0629	single-stranded DNA binding
HZS92_03102	COG0142	geranyltranstransferase activity
HZS92_03105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HZS92_03108	COG0527	aspartate kinase activity
HZS92_03109	COG0384	phenazine biosynthesis protein PhzF
HZS92_03110	COG0384	phenazine biosynthesis protein PhzF
HZS92_03112	COG1764	response to oxidative stress
HZS92_03113	COG0540	Belongs to the ATCase OTCase family
HZS92_03114	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HZS92_03115	COG1678	Uncharacterized ACR, COG1678
HZS92_03117	COG0519	Catalyzes the synthesis of GMP from XMP
HZS92_03119	COG5297	Belongs to the glycosyl hydrolase family 6
HZS92_03122	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HZS92_03125	COG0739	heme binding
HZS92_03129	COG0693	protein deglycase activity
HZS92_03131	COG1959	2 iron, 2 sulfur cluster binding
HZS92_03132	COG0719	Fe-S assembly protein
HZS92_03133	COG0396	ATPase activity
HZS92_03134	COG0719	Fe-S assembly protein
HZS92_03135	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZS92_03137	COG2146	nitrite reductase [NAD(P)H] activity
HZS92_03138	COG4774	siderophore transport
HZS92_03139	COG3128	pkhd-type hydroxylase
HZS92_03144	COG1477	protein flavinylation
HZS92_03145	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HZS92_03148	COG1555	photosystem II stabilization
HZS92_03149	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZS92_03151	COG3178	'Phosphotransferase
HZS92_03152	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HZS92_03154	COG0628	permease
HZS92_03156	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HZS92_03158	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HZS92_03162	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HZS92_03163	COG0271	Belongs to the BolA IbaG family
HZS92_03165	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HZS92_03167	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HZS92_03168	COG1137	ATPase activity
HZS92_03171	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZS92_03172	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HZS92_03173	COG1660	Displays ATPase and GTPase activities
HZS92_03175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZS92_03176	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZS92_03178	COG2239	Acts as a magnesium transporter
HZS92_03181	COG1294	oxidase, subunit
HZS92_03182	COG1271	oxidase subunit
HZS92_03184	COG1113	amino acid transport
HZS92_03190	COG2197	response regulator
HZS92_03191	COG0531	amino acid
HZS92_03198	COG1234	tRNA 3'-trailer cleavage
HZS92_03207	COG2814	Major facilitator Superfamily
HZS92_03209	COG0754	glutathionylspermidine amidase activity
HZS92_03214	COG1842	Phage shock protein A
HZS92_03216	COG0259	pyridoxamine-phosphate oxidase activity
HZS92_03217	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HZS92_03218	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HZS92_03220	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HZS92_03235	COG2814	Major facilitator Superfamily
HZS92_03238	COG2198	Histidine kinase
HZS92_03238	COG2205	protein histidine kinase activity
HZS92_03238	COG0784	Response regulator, receiver
HZS92_03239	COG0784	Response regulator, receiver
HZS92_03239	COG2198	Histidine kinase
HZS92_03239	COG2205	protein histidine kinase activity
HZS92_03240	COG2353	YceI-like domain
HZS92_03244	COG1760	l-serine dehydratase
HZS92_03247	COG0460	homoserine dehydrogenase
HZS92_03247	COG0527	aspartate kinase activity
HZS92_03248	COG0626	cystathionine gamma-synthase activity
HZS92_03249	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZS92_03250	COG0739	heme binding
HZS92_03251	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HZS92_03252	COG1272	protein, Hemolysin III
HZS92_03253	COG2982	Protein involved in outer membrane biogenesis
HZS92_03254	COG0516	GMP reductase activity
HZS92_03254	COG0517	IMP dehydrogenase activity
HZS92_03255	COG0463	Glycosyl transferase, family 2
HZS92_03256	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZS92_03257	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HZS92_03259	COG4771	TonB-dependent receptor
HZS92_03261	COG1309	transcriptional regulator
HZS92_03263	COG1960	acyl-CoA dehydrogenase activity
HZS92_03269	COG0509	glycine decarboxylation via glycine cleavage system
HZS92_03270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HZS92_03272	COG0330	HflC and HflK could
HZS92_03273	COG1742	UPF0060 membrane protein
HZS92_03274	COG3956	TIGRFAM MazG family protein
HZS92_03276	COG0494	nUDIX hydrolase
HZS92_03278	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HZS92_03279	COG0837	glucose binding
HZS92_03282	COG3858	chitin binding
HZS92_03282	COG1388	LysM domain
HZS92_03283	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HZS92_03285	COG1472	Belongs to the glycosyl hydrolase 3 family
HZS92_03288	COG0531	amino acid
HZS92_03290	COG1486	melibiose metabolic process
HZS92_03292	COG3537	Alpha-1,2-mannosidase
HZS92_03300	COG3142	Participates in the control of copper homeostasis
HZS92_03301	COG1446	asparaginase
HZS92_03307	COG0784	Response regulator, receiver
HZS92_03307	COG2198	Histidine kinase
HZS92_03307	COG0643	Histidine kinase
HZS92_03308	COG0840	transmembrane signaling receptor activity
HZS92_03309	COG0835	chemotaxis
HZS92_03312	COG0189	ligase activity
HZS92_03314	COG1397	ADP-ribosylglycohydrolase
HZS92_03316	COG1199	ATP-dependent helicase activity
HZS92_03318	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZS92_03319	COG1215	transferase activity, transferring glycosyl groups
HZS92_03324	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZS92_03326	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HZS92_03327	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HZS92_03328	COG0535	radical SAM domain protein
HZS92_03329	COG0535	radical SAM domain protein
HZS92_03333	COG0837	glucose binding
HZS92_03336	COG1643	Atp-dependent helicase
HZS92_03337	COG0783	Belongs to the Dps family
HZS92_03339	COG0514	ATP-dependent DNA helicase (RecQ)
HZS92_03346	COG0840	transmembrane signaling receptor activity
HZS92_03350	COG3920	Histidine kinase
HZS92_03351	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HZS92_03353	COG0602	queuosine metabolic process
HZS92_03355	COG2885	chlorophyll binding
HZS92_03356	COG0823	Involved in the tonB-independent uptake of proteins
HZS92_03358	COG0848	biopolymer transport protein
HZS92_03360	COG0824	Thioesterase
HZS92_03361	COG2255	four-way junction helicase activity
HZS92_03363	COG3158	transport of potassium into the cell
HZS92_03364	COG0632	four-way junction helicase activity
HZS92_03365	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HZS92_03366	COG0217	transcriptional regulatory protein
HZS92_03369	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HZS92_03372	COG0477	Major facilitator Superfamily
HZS92_03381	COG0488	(ABC) transporter
HZS92_03389	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZS92_03389	COG4651	solute:proton antiporter activity
HZS92_03394	COG4772	TonB-dependent receptor
HZS92_03396	COG4264	IucA IucC family
HZS92_03399	COG0019	diaminopimelate decarboxylase activity
HZS92_03404	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HZS92_03406	COG1492	cobalamin metabolic process
HZS92_03408	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HZS92_03412	COG4206	TonB-dependent receptor
HZS92_03413	COG0542	response to heat
HZS92_03414	COG1116	anion transmembrane transporter activity
HZS92_03415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZS92_03416	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZS92_03417	COG0667	Aldo Keto reductase
HZS92_03418	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZS92_03419	COG4771	TonB-dependent receptor
HZS92_03420	COG2827	Endonuclease containing a URI domain
HZS92_03429	COG1877	trehalose-phosphatase activity
HZS92_03430	COG3387	PFAM Glycoside hydrolase 15-related
HZS92_03434	COG0840	transmembrane signaling receptor activity
HZS92_03435	COG3011	Protein conserved in bacteria
HZS92_03438	COG0564	pseudouridine synthase activity
HZS92_03439	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZS92_03441	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HZS92_03441	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZS92_03443	COG2801	Transposase and inactivated derivatives
HZS92_03446	COG2951	lytic endotransglycosylase activity
HZS92_03447	COG4644	lycopene metabolic process
HZS92_03450	COG2369	cell adhesion
HZS92_03455	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HZS92_03456	COG0045	succinate-CoA ligase (ADP-forming) activity
HZS92_03459	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZS92_03466	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HZS92_03467	COG0237	dephospho-CoA kinase activity
HZS92_03471	COG2801	Transposase and inactivated derivatives
HZS92_03473	COG5002	protein histidine kinase activity
HZS92_03474	COG0745	RESPONSE REGULATOR receiver
HZS92_03476	COG0189	ligase activity
HZS92_03492	COG2003	Belongs to the UPF0758 family
HZS92_03497	COG0784	Response regulator, receiver
HZS92_03497	COG4191	Histidine kinase
HZS92_03498	COG0784	Response regulator, receiver
HZS92_03498	COG4191	Histidine kinase
HZS92_03524	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HZS92_03531	COG2022	thiamine diphosphate biosynthetic process
HZS92_03532	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HZS92_03533	COG3273	potassium ion transport
HZS92_03533	COG0471	metal ion transport
HZS92_03538	COG1970	mechanosensitive ion channel activity
HZS92_03542	COG3250	beta-galactosidase activity
HZS92_03543	COG4948	Mandelate Racemase Muconate Lactonizing
HZS92_03546	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZS92_03548	COG0308	aminopeptidase N
HZS92_03550	COG2801	Transposase and inactivated derivatives
HZS92_03551	COG2963	transposase activity
HZS92_03556	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZS92_03558	COG0529	Catalyzes the synthesis of activated sulfate
HZS92_03558	COG2895	sulfate adenylyltransferase (ATP) activity
HZS92_03559	COG0175	sulfate reduction
HZS92_03560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HZS92_03561	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZS92_03562	COG0175	sulfate reduction
HZS92_03566	COG0784	Response regulator, receiver
HZS92_03566	COG2198	Histidine kinase
HZS92_03566	COG2205	protein histidine kinase activity
HZS92_03570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HZS92_03570	COG1648	precorrin-2 dehydrogenase activity
HZS92_03573	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HZS92_03574	COG3588	fructose-bisphosphate aldolase
HZS92_03577	COG0469	pyruvate kinase activity
HZS92_03579	COG0126	phosphoglycerate kinase activity
HZS92_03584	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HZS92_03586	COG3047	cAMP biosynthetic process
HZS92_03587	COG3047	cAMP biosynthetic process
HZS92_03589	COG3453	Protein conserved in bacteria
HZS92_03589	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZS92_03590	COG0725	ABC transporter, periplasmic molybdate-binding protein
HZS92_03591	COG4149	molybdate abc transporter
HZS92_03592	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HZS92_03599	COG1376	ErfK ybiS ycfS ynhG family protein
HZS92_03600	COG0739	heme binding
HZS92_03602	COG4773	Receptor
HZS92_03603	COG0596	Alpha beta hydrolase
HZS92_03604	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HZS92_03605	COG1301	dicarboxylic acid transport
HZS92_03607	COG2304	oxidoreductase activity
HZS92_03611	COG0714	Associated with various cellular activities
HZS92_03618	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HZS92_03623	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HZS92_03625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZS92_03627	COG0194	GDP metabolic process
HZS92_03628	COG1561	YicC-like family, N-terminal region
HZS92_03629	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HZS92_03631	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HZS92_03632	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZS92_03635	COG0006	proline dipeptidase activity
HZS92_03637	COG0006	proline dipeptidase activity
HZS92_03638	COG3079	Belongs to the UPF0149 family
HZS92_03642	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HZS92_03644	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HZS92_03646	COG2912	Transglutaminase-like superfamily
HZS92_03647	COG1773	rubredoxin
HZS92_03648	COG0352	thiamine-phosphate diphosphorylase activity
HZS92_03650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZS92_03653	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZS92_03659	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZS92_03660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZS92_03662	COG1028	Short-chain dehydrogenase reductase Sdr
HZS92_03664	COG0671	phosphoesterase, PA-phosphatase related
HZS92_03665	COG3781	membrane
HZS92_03667	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZS92_03668	COG0563	adenylate kinase activity
HZS92_03671	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HZS92_03673	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HZS92_03677	COG3710	Transcriptional regulator
HZS92_03678	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HZS92_03681	COG0840	transmembrane signaling receptor activity
HZS92_03682	COG0405	Gamma-glutamyltransferase
HZS92_03683	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HZS92_03687	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZS92_03688	COG0473	3-isopropylmalate dehydrogenase activity
HZS92_03689	COG0066	3-isopropylmalate dehydratase activity
HZS92_03690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HZS92_03694	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HZS92_03695	COG1538	Outer membrane efflux protein
HZS92_03696	COG1519	Transferase
HZS92_03697	COG1560	Kdo2-lipid A biosynthetic process
HZS92_03702	COG0281	malic enzyme
HZS92_03702	COG0280	phosphate acetyltransferase
HZS92_03703	COG1301	dicarboxylic acid transport
HZS92_03708	COG0583	DNA-binding transcription factor activity
HZS92_03709	COG0667	Aldo Keto reductase
HZS92_03712	COG2197	response regulator
HZS92_03714	COG0642	Histidine kinase
HZS92_03718	COG2851	Citrate transporter
HZS92_03719	COG1028	Short-chain dehydrogenase reductase Sdr
HZS92_03720	COG1609	Transcriptional regulator
HZS92_03722	COG2211	Major facilitator Superfamily
HZS92_03727	COG1162	GTPase activity
HZS92_03733	COG4773	Receptor
HZS92_03734	COG0726	polysaccharide deacetylase
HZS92_03735	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HZS92_03738	COG2801	Transposase and inactivated derivatives
HZS92_03742	COG1307	EDD domain protein, DegV family
HZS92_03743	COG0242	peptide deformylase activity
HZS92_03749	COG0457	Tetratricopeptide repeat
HZS92_03750	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HZS92_03751	COG1215	transferase activity, transferring glycosyl groups
HZS92_03752	COG1215	transferase activity, transferring glycosyl groups
HZS92_03755	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HZS92_03766	COG2188	Transcriptional regulator
HZS92_03769	COG1450	Type ii and iii secretion system protein
HZS92_03772	COG3166	PFAM Fimbrial assembly family protein
HZS92_03773	COG3156	type II secretion system protein K
HZS92_03774	COG4795	General secretion pathway protein
HZS92_03775	COG2165	general secretion pathway protein
HZS92_03776	COG4970	Tfp pilus assembly protein FimT
HZS92_03777	COG2165	general secretion pathway protein
HZS92_03778	COG1459	type II secretion system
HZS92_03780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZS92_03781	COG1404	Belongs to the peptidase S8 family
HZS92_03782	COG5295	Hep Hag repeat protein
HZS92_03783	COG1404	Belongs to the peptidase S8 family
HZS92_03784	COG5295	Hep Hag repeat protein
HZS92_03786	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZS92_03786	COG0047	phosphoribosylformylglycinamidine synthase activity
HZS92_03788	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HZS92_03790	COG4974	Belongs to the 'phage' integrase family
HZS92_03793	COG0795	lipopolysaccharide-transporting ATPase activity
HZS92_03795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HZS92_03798	COG0525	valine-tRNA ligase activity
HZS92_03804	COG1183	phosphatidylcholine synthase activity
HZS92_03806	COG0442	prolyl-tRNA aminoacylation
HZS92_03809	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HZS92_03810	COG1127	ABC transporter
HZS92_03811	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HZS92_03811	COG3218	ABC-type transport auxiliary lipoprotein component
HZS92_03818	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZS92_03819	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HZS92_03819	COG0662	Cupin 2, conserved barrel domain protein
HZS92_03826	COG2086	electron transfer activity
HZS92_03829	COG0546	phosphoglycolate phosphatase activity
HZS92_03829	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HZS92_03830	COG0277	FAD linked oxidase domain protein
HZS92_03833	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZS92_03839	COG0438	transferase activity, transferring glycosyl groups
HZS92_03839	COG1216	Glycosyl transferase, family 2
HZS92_03843	COG0626	cystathionine gamma-synthase activity
HZS92_03849	COG0625	glutathione transferase activity
HZS92_03852	COG0513	Belongs to the DEAD box helicase family
HZS92_03854	COG4206	TonB-dependent receptor
HZS92_03856	COG0720	synthase
HZS92_03858	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HZS92_03860	COG1956	GAF domain-containing protein
HZS92_03862	COG2819	hydrolase of the alpha beta superfamily
HZS92_03865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZS92_03866	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZS92_03869	COG0339	signal peptide processing
HZS92_03880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZS92_03881	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS92_03882	COG4591	ABC-type transport system involved in lipoprotein release permease component
HZS92_03882	COG1136	(ABC) transporter
HZS92_03883	COG0577	efflux transmembrane transporter activity
HZS92_03883	COG1136	(ABC) transporter
HZS92_03884	COG0577	efflux transmembrane transporter activity
HZS92_03888	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HZS92_03891	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HZS92_03892	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HZS92_03893	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HZS92_03894	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HZS92_03895	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZS92_03896	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HZS92_03898	COG0356	it plays a direct role in the translocation of protons across the membrane
HZS92_03902	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZS92_03904	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZS92_03912	COG2011	ABC-type metal ion transport system permease component
HZS92_03913	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HZS92_03914	COG0697	spore germination
HZS92_03915	COG1666	GTP binding
HZS92_03917	COG5002	protein histidine kinase activity
HZS92_03917	COG2198	Histidine kinase
HZS92_03917	COG0784	Response regulator, receiver
HZS92_03922	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZS92_03923	COG1187	pseudouridine synthase activity
HZS92_03924	COG2813	Specifically methylates the guanine in position
HZS92_03928	COG2202	Pas domain
HZS92_03928	COG2205	protein histidine kinase activity
HZS92_03932	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HZS92_03933	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZS92_03945	COG0842	Transport permease protein
HZS92_03946	COG1131	(ABC) transporter
HZS92_03947	COG0025	NhaP-type Na H and K H
HZS92_03949	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HZS92_03950	COG1573	uracil-dna glycosylase
HZS92_03952	COG3384	dioxygenase
HZS92_03954	COG0583	DNA-binding transcription factor activity
HZS92_03956	COG0667	Aldo Keto reductase
HZS92_03959	COG3590	peptidase
HZS92_03963	COG0531	amino acid
HZS92_03966	COG2972	Histidine kinase
HZS92_03971	COG3685	Protein conserved in bacteria
HZS92_03972	COG3546	catalase activity
HZS92_03982	COG1271	oxidase subunit
HZS92_03983	COG1294	oxidase, subunit
HZS92_03986	COG1028	Short-chain dehydrogenase reductase Sdr
HZS92_03987	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HZS92_03991	COG1132	(ABC) transporter
HZS92_03994	COG1063	alcohol dehydrogenase
HZS92_04009	COG0251	oxidation-reduction process
HZS92_04015	COG0840	transmembrane signaling receptor activity
HZS92_04019	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HZS92_04028	COG0024	Methionine aminopeptidase
HZS92_04035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZS92_04036	COG1490	D-aminoacyl-tRNA deacylase activity
HZS92_04037	COG1560	Kdo2-lipid A biosynthetic process
HZS92_04048	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HZS92_04048	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZS92_04049	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HZS92_04050	COG0242	peptide deformylase activity
HZS92_04051	COG1652	LysM domain
HZS92_04052	COG0758	DNA mediated transformation
HZS92_04053	COG2922	Belongs to the Smg family
HZS92_04056	COG1754	DNA topoisomerase type I activity
HZS92_04056	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZS92_04057	COG0009	L-threonylcarbamoyladenylate synthase
HZS92_04060	COG1028	Short-chain dehydrogenase reductase Sdr
HZS92_04062	COG0616	signal peptide processing
HZS92_04063	COG0534	Mate efflux family protein
HZS92_04067	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HZS92_04068	COG0625	glutathione transferase activity
HZS92_04071	COG1252	NADH dehydrogenase
HZS92_04072	COG2860	membrane
HZS92_04073	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZS92_04074	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HZS92_04075	COG3437	response regulator, receiver
HZS92_04076	COG2177	Part of the ABC transporter FtsEX involved in
HZS92_04077	COG2884	Cell division ATP-binding protein ftsE
HZS92_04078	COG0513	Belongs to the DEAD box helicase family
HZS92_04079	COG3118	belongs to the thioredoxin family
HZS92_04080	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HZS92_04082	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HZS92_04083	COG0583	DNA-binding transcription factor activity
HZS92_04092	COG1518	maintenance of DNA repeat elements
HZS92_04093	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HZS92_04095	COG1652	LysM domain
HZS92_04096	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HZS92_04096	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HZS92_04097	COG1473	amidohydrolase
HZS92_04098	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS92_04099	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZS92_04101	COG5383	Protein conserved in bacteria
HZS92_04112	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HZS92_04113	COG3023	N-Acetylmuramoyl-L-alanine amidase
HZS92_04115	COG4948	Mandelate Racemase Muconate Lactonizing
HZS92_04117	COG0531	amino acid
HZS92_04120	COG4682	membrane
HZS92_04121	COG2133	pyrroloquinoline quinone binding
HZS92_04123	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HZS92_04124	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HZS92_04126	COG1610	YqeY-like protein
HZS92_04128	COG1295	ribonuclease BN
HZS92_04129	COG0358	DNA primase activity
HZS92_04132	COG0109	protoheme IX farnesyltransferase activity
HZS92_04138	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HZS92_04141	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HZS92_04150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HZS92_04151	COG0739	heme binding
HZS92_04152	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HZS92_04154	COG2211	Major facilitator Superfamily
HZS92_04155	COG0708	Exodeoxyribonuclease III
HZS92_04156	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HZS92_04158	COG1192	Involved in chromosome partitioning
HZS92_04159	COG1475	DNA binding
HZS92_04163	COG0463	Glycosyl transferase, family 2
HZS92_04167	COG0756	dUTP diphosphatase activity
HZS92_04168	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZS92_04169	COG2003	Belongs to the UPF0758 family
HZS92_04170	COG0018	arginyl-trna synthetase
HZS92_04173	COG4221	oxidoreductase activity
HZS92_04174	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HZS92_04174	COG2755	lipolytic protein G-D-S-L family
HZS92_04176	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZS92_04177	COG1166	arginine decarboxylase activity
HZS92_04178	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HZS92_04187	COG0606	chelatase, subunit chli
HZS92_04190	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HZS92_04197	COG1690	Belongs to the RtcB family
HZS92_04204	COG1090	epimerase
HZS92_04206	COG0642	Histidine kinase
HZS92_04212	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZS92_04217	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZS92_04218	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HZS92_04221	COG0753	catalase activity
HZS92_04224	COG2197	response regulator
HZS92_04225	COG4585	Histidine kinase
HZS92_04226	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS92_04227	COG1136	(ABC) transporter
HZS92_04231	COG2962	Rard protein
HZS92_04232	COG0697	spore germination
HZS92_04236	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZS92_04237	COG0180	Tryptophanyl-tRNA synthetase
HZS92_04238	COG3237	CsbD-like
HZS92_04247	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HZS92_04250	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HZS92_04260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZS92_04266	COG1199	ATP-dependent helicase activity
HZS92_04269	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HZS92_04282	COG0625	glutathione transferase activity
HZS92_04290	COG4555	ABC transporter
HZS92_04292	COG1476	TRANSCRIPTIONal
HZS92_04301	COG0543	2 iron, 2 sulfur cluster binding
HZS92_04301	COG0633	Ferredoxin
HZS92_04302	COG1131	(ABC) transporter
HZS92_04303	COG0842	Transport permease protein
HZS92_04305	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HZS92_04312	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZS92_04313	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZS92_04316	COG0045	succinate-CoA ligase (ADP-forming) activity
HZS92_04316	COG1042	CoA-binding domain protein
HZS92_04316	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZS92_04317	COG2239	Acts as a magnesium transporter
HZS92_04318	COG3338	carbonate dehydratase activity
HZS92_04320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HZS92_04321	COG3387	PFAM Glycoside hydrolase 15-related
HZS92_04324	COG3100	YcgL domain-containing protein
HZS92_04325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZS92_04327	COG0463	Glycosyl transferase, family 2
HZS92_04331	COG1028	Short-chain dehydrogenase reductase Sdr
HZS92_04339	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZS92_04342	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZS92_04348	COG0823	Involved in the tonB-independent uptake of proteins
HZS92_04348	COG1506	peptidase
HZS92_04348	COG4946	Tricorn protease homolog
HZS92_04352	COG0408	coproporphyrinogen oxidase activity
HZS92_04360	COG0515	serine threonine protein kinase
HZS92_04360	COG2815	serine threonine protein kinase
HZS92_04361	COG0631	protein serine/threonine phosphatase activity
HZS92_04397	COG0210	DNA helicase
HZS92_04400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZS92_04401	COG0583	DNA-binding transcription factor activity
HZS92_04402	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HZS92_04405	COG2159	amidohydrolase
HZS92_04409	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS92_04413	COG0357	Ribosomal RNA small subunit methyltransferase G
HZS92_04414	COG3540	Alkaline phosphatase
HZS92_04416	COG2091	lysine biosynthetic process via aminoadipic acid
HZS92_04419	COG0708	Exodeoxyribonuclease III
HZS92_04420	COG1846	Transcriptional regulator
HZS92_04420	COG1940	carbohydrate kinase activity
HZS92_04422	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZS92_04424	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZS92_04425	COG3162	membrane
HZS92_04427	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZS92_04433	COG3507	Belongs to the glycosyl hydrolase 43 family
HZS92_04437	COG1028	Short-chain dehydrogenase reductase Sdr
HZS92_04438	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZS92_04440	COG4948	Mandelate Racemase Muconate Lactonizing
HZS92_04441	COG3254	rhamnose metabolic process
HZS92_04442	COG0738	Major facilitator superfamily
HZS92_04443	COG1414	Transcriptional regulator
HZS92_04444	COG1971	Probably functions as a manganese efflux pump
HZS92_04445	COG2205	protein histidine kinase activity
HZS92_04448	COG3459	Glycosyltransferase 36 associated
HZS92_04449	COG2211	Major facilitator Superfamily
HZS92_04450	COG3265	gluconokinase activity
HZS92_04451	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZS92_04455	COG2911	Protein conserved in bacteria
HZS92_04456	COG0729	surface antigen
HZS92_04461	COG2801	Transposase and inactivated derivatives
HZS92_04464	COG0752	glycyl-tRNA synthetase alpha subunit
HZS92_04465	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZS92_04468	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HZS92_04468	COG0519	Catalyzes the synthesis of GMP from XMP
HZS92_04470	COG0805	protein transport
HZS92_04471	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZS92_04472	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZS92_04474	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HZS92_04479	COG2974	May be involved in recombination
HZS92_04480	COG0037	tRNA processing
HZS92_04482	COG2115	Belongs to the xylose isomerase family
HZS92_04484	COG3661	Belongs to the glycosyl hydrolase 67 family
HZS92_04486	COG4948	Mandelate Racemase Muconate Lactonizing
HZS92_04488	COG1472	Belongs to the glycosyl hydrolase 3 family
HZS92_04489	COG0246	Mannitol dehydrogenase
HZS92_04499	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZS92_04505	COG3386	PFAM SMP-30 Gluconolaconase
HZS92_04507	COG3250	beta-galactosidase activity
HZS92_04508	COG1904	glucuronate isomerase
HZS92_04509	COG3693	PFAM glycoside hydrolase, family 10
HZS92_04511	COG3693	PFAM glycoside hydrolase, family 10
HZS92_04514	COG2211	Major facilitator Superfamily
HZS92_04528	COG2937	Belongs to the GPAT DAPAT family
HZS92_04535	COG0284	orotidine-5'-phosphate decarboxylase activity
HZS92_04536	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HZS92_04538	COG3132	Protein of unknown function, DUF480
HZS92_04541	COG0210	DNA helicase
HZS92_04542	COG1435	thymidine kinase activity
HZS92_04544	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HZS92_04546	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HZS92_04553	COG3135	benzoate transporter
HZS92_04557	COG0676	glucose-6-phosphate 1-epimerase activity
HZS92_04559	COG3012	SEC-C Motif Domain Protein
HZS92_04560	COG0730	response to heat
HZS92_04565	COG0302	gtp cyclohydrolase
HZS92_04568	COG1566	PFAM secretion protein HlyD family protein
HZS92_04570	COG1289	transmembrane transporter activity
HZS92_04571	COG0477	Major facilitator Superfamily
HZS92_04573	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZS92_04577	COG4691	Plasmid stability protein
HZS92_04578	COG1487	ribonuclease activity
HZS92_04585	COG0564	pseudouridine synthase activity
HZS92_04589	COG2801	Transposase and inactivated derivatives
HZS92_04592	COG0439	Biotin carboxylase
HZS92_04600	COG1074	ATP-dependent DNA helicase activity
HZS92_04601	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HZS92_04604	COG1127	ABC transporter
HZS92_04605	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HZS92_04606	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HZS92_04609	COG2853	Lipoprotein
HZS92_04611	COG0386	Belongs to the glutathione peroxidase family
HZS92_04613	COG1322	Protein conserved in bacteria
HZS92_04614	COG0604	alcohol dehydrogenase
HZS92_04618	COG0625	glutathione transferase activity
HZS92_04620	COG0531	amino acid
HZS92_04622	COG3537	Alpha-1,2-mannosidase
HZS92_04625	COG3706	GGDEF domain
HZS92_04626	COG3835	regulator
HZS92_04627	COG1929	Belongs to the glycerate kinase type-1 family
HZS92_04628	COG2271	Major facilitator Superfamily
HZS92_04631	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HZS92_04633	COG0861	Integral membrane protein TerC family
HZS92_04636	COG0584	glycerophosphoryl diester phosphodiesterase
HZS92_04639	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HZS92_04640	COG0726	polysaccharide deacetylase
HZS92_04641	COG0706	membrane insertase activity
HZS92_04642	COG0594	ribonuclease P activity
HZS92_04644	COG2963	transposase activity
HZS92_04648	COG2801	Transposase and inactivated derivatives
HZS92_04652	COG3250	beta-galactosidase activity
HZS92_04657	COG0534	Mate efflux family protein
HZS92_04676	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZS92_06015	COG3012	SEC-C Motif Domain Protein
HZS92_06015	COG3318	Belongs to the UPF0149 family
HZS92_06021	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZS92_06025	COG1192	Involved in chromosome partitioning
HZS92_06031	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZS92_06057	COG4644	lycopene metabolic process
HZS92_06058	COG2951	lytic endotransglycosylase activity
HZS92_06068	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZS92_06074	COG3012	SEC-C Motif Domain Protein
HZS92_06074	COG3318	Belongs to the UPF0149 family
HZS92_06110	COG2948	multi-organism process
HZS92_06111	COG3504	Conjugal transfer protein
HZS92_06132	COG4456	Virulence-associated protein
HZS92_06134	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZS92_06135	COG2801	Transposase and inactivated derivatives
HZS92_06145	COG1192	Involved in chromosome partitioning
HZS92_06163	COG3012	SEC-C Motif Domain Protein
HZS92_06163	COG3318	Belongs to the UPF0149 family
HZS92_06169	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZS92_06179	COG2951	lytic endotransglycosylase activity
HZS92_06180	COG4644	lycopene metabolic process
HZS92_07011	COG3318	Belongs to the UPF0149 family
HZS92_07011	COG3012	SEC-C Motif Domain Protein
HZS92_07017	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZS92_07026	COG4644	lycopene metabolic process
HZS92_07027	COG2951	lytic endotransglycosylase activity
HZS92_07037	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZS92_07043	COG3012	SEC-C Motif Domain Protein
HZS92_07043	COG3318	Belongs to the UPF0149 family
HZS92_07078	COG2948	multi-organism process
HZS92_07079	COG3504	Conjugal transfer protein
HZS92_07100	COG4456	Virulence-associated protein
HZS92_07102	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZS92_07103	COG2801	Transposase and inactivated derivatives
HZS92_07113	COG1192	Involved in chromosome partitioning