locus-tag	class	description
H8Z73_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H8Z73_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8Z73_00020	COG0187	DNA topoisomerase II activity
H8Z73_00030	COG0501	Belongs to the peptidase M48B family
H8Z73_00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H8Z73_00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z73_00115	COG0793	Belongs to the peptidase S41A family
H8Z73_00120	COG4942	peptidase
H8Z73_00130	COG2234	aminopeptidase activity
H8Z73_00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z73_00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z73_00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z73_00165	COG1064	alcohol dehydrogenase
H8Z73_00175	COG0493	'glutamate synthase
H8Z73_00180	COG0067	glutamate synthase
H8Z73_00180	COG0069	glutamate synthase activity
H8Z73_00180	COG0070	glutamate synthase
H8Z73_00230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8Z73_00245	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H8Z73_00250	COG0438	transferase activity, transferring glycosyl groups
H8Z73_00250	COG0297	glycogen (starch) synthase activity
H8Z73_00270	COG0367	asparagine synthase
H8Z73_00300	COG1132	(ABC) transporter
H8Z73_00330	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H8Z73_00415	COG1111	helicase
H8Z73_00415	COG1205	dead DEAH box helicase
H8Z73_00420	COG1272	protein, Hemolysin III
H8Z73_00440	COG0300	oxidoreductase activity
H8Z73_00445	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_00465	COG2249	NAD(P)H dehydrogenase (quinone) activity
H8Z73_00520	COG3237	CsbD-like
H8Z73_00565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z73_00570	COG0477	Major facilitator Superfamily
H8Z73_00610	COG0714	Associated with various cellular activities
H8Z73_00640	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H8Z73_00650	COG4772	TonB-dependent receptor
H8Z73_00660	COG0662	Cupin 2, conserved barrel domain protein
H8Z73_00665	COG1012	belongs to the aldehyde dehydrogenase family
H8Z73_00690	COG1304	FMN binding
H8Z73_00700	COG4585	Histidine kinase
H8Z73_00705	COG2197	response regulator
H8Z73_00725	COG3710	Transcriptional regulator
H8Z73_00730	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H8Z73_00800	COG0366	Alpha amylase catalytic
H8Z73_00805	COG0366	Alpha amylase catalytic
H8Z73_00810	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z73_00830	COG2755	lipolytic protein G-D-S-L family
H8Z73_00830	COG0657	acetylesterase activity
H8Z73_00840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H8Z73_00855	COG3507	Belongs to the glycosyl hydrolase 43 family
H8Z73_00860	COG1609	Transcriptional regulator
H8Z73_00865	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H8Z73_00870	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_00880	COG2755	lipolytic protein G-D-S-L family
H8Z73_00895	COG3186	Phenylalanine-4-hydroxylase
H8Z73_00900	COG1522	sequence-specific DNA binding
H8Z73_00910	COG1752	Esterase of the alpha-beta hydrolase superfamily
H8Z73_00920	COG1119	ATPase activity
H8Z73_00935	COG1125	glycine betaine transport
H8Z73_00950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8Z73_00970	COG1396	sequence-specific DNA binding
H8Z73_00990	COG0489	protein tyrosine kinase activity
H8Z73_00995	COG2062	phosphohistidine phosphatase, SixA
H8Z73_01005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z73_01050	COG1968	undecaprenyl-diphosphatase activity
H8Z73_01055	COG0174	glutamine synthetase
H8Z73_01060	COG0347	Belongs to the P(II) protein family
H8Z73_01065	COG0004	ammonium transporteR
H8Z73_01070	COG3852	Histidine kinase
H8Z73_01075	COG2204	response regulator
H8Z73_01080	COG2032	superoxide dismutase activity
H8Z73_01085	COG2032	superoxide dismutase activity
H8Z73_01095	COG0346	lactoylglutathione lyase activity
H8Z73_01105	COG0183	Belongs to the thiolase family
H8Z73_01140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8Z73_01145	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H8Z73_01150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H8Z73_01165	COG0028	Belongs to the TPP enzyme family
H8Z73_01170	COG2205	protein histidine kinase activity
H8Z73_01195	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H8Z73_01210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z73_01220	COG0596	Alpha beta hydrolase
H8Z73_01225	COG0727	PFAM Uncharacterised protein family (UPF0153)
H8Z73_01230	COG0318	PFAM AMP-dependent synthetase and ligase
H8Z73_01235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z73_01245	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8Z73_01255	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8Z73_01290	COG0339	signal peptide processing
H8Z73_01320	COG0475	glutathione-regulated potassium exporter activity
H8Z73_01325	COG0583	DNA-binding transcription factor activity
H8Z73_01330	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H8Z73_01335	COG2224	Isocitrate lyase
H8Z73_01370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H8Z73_01375	COG1960	acyl-CoA dehydrogenase activity
H8Z73_01430	COG0523	cobalamin synthesis protein
H8Z73_01440	COG0697	spore germination
H8Z73_01450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H8Z73_01455	COG1846	Transcriptional regulator
H8Z73_01460	COG1764	response to oxidative stress
H8Z73_01485	COG2130	NADP-dependent
H8Z73_01500	COG1187	pseudouridine synthase activity
H8Z73_01515	COG1643	Atp-dependent helicase
H8Z73_01520	COG4807	Protein conserved in bacteria
H8Z73_01525	COG2351	hydroxyisourate hydrolase activity
H8Z73_01530	COG2072	flavoprotein involved in K transport
H8Z73_01550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H8Z73_01585	COG1957	nucleoside hydrolase
H8Z73_01595	COG2252	PERMEase
H8Z73_01615	COG0084	hydrolase, TatD family'
H8Z73_01630	COG0583	DNA-binding transcription factor activity
H8Z73_01635	COG2814	Major facilitator Superfamily
H8Z73_01650	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H8Z73_01655	COG1902	pentaerythritol trinitrate reductase activity
H8Z73_01675	COG0745	RESPONSE REGULATOR receiver
H8Z73_01680	COG2205	protein histidine kinase activity
H8Z73_01685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z73_01705	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H8Z73_01710	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8Z73_01715	COG0583	DNA-binding transcription factor activity
H8Z73_01745	COG0702	epimerase
H8Z73_01750	COG1733	regulation of RNA biosynthetic process
H8Z73_01780	COG0129	dihydroxy-acid dehydratase activity
H8Z73_01795	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H8Z73_01850	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H8Z73_01855	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H8Z73_01880	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H8Z73_01885	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H8Z73_01895	COG3485	protocatechuate 3,4-dioxygenase
H8Z73_01900	COG3485	protocatechuate 3,4-dioxygenase
H8Z73_01910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z73_01915	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H8Z73_01925	COG1414	Transcriptional regulator
H8Z73_01935	COG0657	acetylesterase activity
H8Z73_01945	COG0445	tRNA wobble uridine modification
H8Z73_01955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H8Z73_01985	COG2267	carboxylic ester hydrolase activity
H8Z73_01995	COG0156	8-amino-7-oxononanoate synthase activity
H8Z73_02000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H8Z73_02005	COG1040	competence protein
H8Z73_02010	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8Z73_02090	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8Z73_02160	COG1511	domain protein
H8Z73_02160	COG3264	Mechanosensitive ion channel
H8Z73_02165	COG1368	sulfuric ester hydrolase activity
H8Z73_02170	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8Z73_02175	COG2354	Protein conserved in bacteria
H8Z73_02185	COG0297	glycogen (starch) synthase activity
H8Z73_02190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z73_02195	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z73_02220	COG0702	epimerase
H8Z73_02225	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_02255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z73_02260	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_02270	COG0513	Belongs to the DEAD box helicase family
H8Z73_02290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H8Z73_02300	COG3483	tryptophan 2,3-dioxygenase activity
H8Z73_02305	COG3104	oligopeptide transport
H8Z73_02330	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H8Z73_02345	COG1320	monovalent cation:proton antiporter activity
H8Z73_02350	COG2212	antiporter activity
H8Z73_02360	COG0651	ATP synthesis coupled electron transport
H8Z73_02365	COG1006	Multisubunit Na H antiporter MnhC subunit
H8Z73_02370	COG2111	Na H antiporter
H8Z73_02370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8Z73_02390	COG3179	chitinase
H8Z73_02410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H8Z73_02415	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H8Z73_02430	COG0456	acetyltransferase
H8Z73_02435	COG1597	lipid kinase activity
H8Z73_02460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8Z73_02465	COG0134	indole-3-glycerol-phosphate synthase activity
H8Z73_02475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z73_02480	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H8Z73_02490	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H8Z73_02500	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H8Z73_02515	COG1051	belongs to the nudix hydrolase family
H8Z73_02555	COG0316	Belongs to the HesB IscA family
H8Z73_02570	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8Z73_02585	COG2814	Major facilitator Superfamily
H8Z73_02590	COG0583	DNA-binding transcription factor activity
H8Z73_02595	COG2814	Major facilitator Superfamily
H8Z73_02600	COG1289	transmembrane transporter activity
H8Z73_02610	COG0151	Belongs to the GarS family
H8Z73_02620	COG0138	bifunctional purine biosynthesis protein purh
H8Z73_02625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8Z73_02630	COG2267	carboxylic ester hydrolase activity
H8Z73_02635	COG2453	phosphatase
H8Z73_02635	COG0671	phosphoesterase, PA-phosphatase related
H8Z73_02660	COG4589	Belongs to the CDS family
H8Z73_02665	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H8Z73_02700	COG0439	Biotin carboxylase
H8Z73_02710	COG0511	ligase activity, forming carbon-carbon bonds
H8Z73_02715	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H8Z73_02725	COG1324	tolerance protein
H8Z73_02750	COG0300	oxidoreductase activity
H8Z73_02755	COG2356	endonuclease I
H8Z73_02770	COG0459	protein refolding
H8Z73_02785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H8Z73_02800	COG3386	PFAM SMP-30 Gluconolaconase
H8Z73_02810	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H8Z73_02815	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8Z73_02830	COG0778	Nitroreductase
H8Z73_02835	COG2353	YceI-like domain
H8Z73_02865	COG3052	prosthetic group binding
H8Z73_02890	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8Z73_02900	COG1802	Transcriptional regulator
H8Z73_02955	COG4221	oxidoreductase activity
H8Z73_02970	COG4221	oxidoreductase activity
H8Z73_02980	COG0435	Glutathione S-transferase
H8Z73_03005	COG2409	Drug exporters of the RND superfamily
H8Z73_03010	COG0823	Involved in the tonB-independent uptake of proteins
H8Z73_03010	COG1506	peptidase
H8Z73_03050	COG0697	spore germination
H8Z73_03065	COG1113	amino acid transport
H8Z73_03085	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H8Z73_03120	COG5001	Diguanylate cyclase
H8Z73_03125	COG0840	transmembrane signaling receptor activity
H8Z73_03130	COG5297	Belongs to the glycosyl hydrolase family 6
H8Z73_03130	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z73_03135	COG0659	secondary active sulfate transmembrane transporter activity
H8Z73_03150	COG2943	transferase activity, transferring hexosyl groups
H8Z73_03160	COG3275	phosphorelay sensor kinase activity
H8Z73_03170	COG0181	hydroxymethylbilane synthase activity
H8Z73_03200	COG0436	Aminotransferase
H8Z73_03210	COG2832	Protein of unknown function (DUF454)
H8Z73_03220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H8Z73_03230	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H8Z73_03235	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H8Z73_03240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H8Z73_03265	COG2226	methyltransferase
H8Z73_03270	COG5001	Diguanylate cyclase
H8Z73_03270	COG3300	MHYT domain
H8Z73_03275	COG0308	aminopeptidase N
H8Z73_03320	COG3284	Transcriptional regulator
H8Z73_03325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z73_03330	COG1077	Cell shape determining protein MreB Mrl
H8Z73_03335	COG1792	Involved in formation and maintenance of cell shape
H8Z73_03350	COG0772	Belongs to the SEDS family
H8Z73_03360	COG2951	lytic endotransglycosylase activity
H8Z73_03365	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H8Z73_03370	COG1686	Belongs to the peptidase S11 family
H8Z73_03380	COG2921	Belongs to the UPF0250 family
H8Z73_03385	COG0321	lipoyl(octanoyl) transferase activity
H8Z73_03390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8Z73_03405	COG0583	DNA-binding transcription factor activity
H8Z73_03415	COG1051	belongs to the nudix hydrolase family
H8Z73_03415	COG1056	cytidyltransferase-related domain
H8Z73_03450	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H8Z73_03455	COG0673	inositol 2-dehydrogenase activity
H8Z73_03460	COG2823	Periplasmic or secreted lipoprotein
H8Z73_03465	COG4251	negative regulation of phosphorylation
H8Z73_03470	COG0784	Response regulator, receiver
H8Z73_03475	COG4191	Histidine kinase
H8Z73_03480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H8Z73_03485	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_03535	COG1459	type II secretion system
H8Z73_03585	COG3250	beta-galactosidase activity
H8Z73_03600	COG2188	Transcriptional regulator
H8Z73_03610	COG1609	Transcriptional regulator
H8Z73_03615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8Z73_03620	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H8Z73_03630	COG0617	tRNA 3'-terminal CCA addition
H8Z73_03635	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H8Z73_03640	COG1012	belongs to the aldehyde dehydrogenase family
H8Z73_03645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H8Z73_03660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8Z73_03675	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H8Z73_03680	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8Z73_03695	COG2205	protein histidine kinase activity
H8Z73_03725	COG3791	Glutathione-dependent formaldehyde-activating
H8Z73_03740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8Z73_03750	COG0697	spore germination
H8Z73_03760	COG0488	(ABC) transporter
H8Z73_03770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H8Z73_03775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H8Z73_03785	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8Z73_03785	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8Z73_03805	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H8Z73_03810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8Z73_03815	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H8Z73_03835	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H8Z73_03840	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H8Z73_03845	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H8Z73_03850	COG2205	protein histidine kinase activity
H8Z73_03855	COG0745	RESPONSE REGULATOR receiver
H8Z73_03870	COG0277	FAD linked oxidase domain protein
H8Z73_03875	COG1988	membrane-bound metal-dependent
H8Z73_03880	COG0792	nuclease activity
H8Z73_03915	COG0275	rRNA processing
H8Z73_03920	COG3116	cell division
H8Z73_03930	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8Z73_03935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H8Z73_03940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8Z73_03950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8Z73_03955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8Z73_03960	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8Z73_03965	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H8Z73_03980	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H8Z73_03990	COG0739	heme binding
H8Z73_03995	COG0653	protein targeting
H8Z73_04000	COG0494	nUDIX hydrolase
H8Z73_04010	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H8Z73_04020	COG3321	synthase
H8Z73_04020	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_04020	COG0604	alcohol dehydrogenase
H8Z73_04035	COG0366	Alpha amylase catalytic
H8Z73_04060	COG2226	methyltransferase
H8Z73_04065	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H8Z73_04075	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H8Z73_04115	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H8Z73_04125	COG4106	trans-aconitate 2-methyltransferase activity
H8Z73_04130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8Z73_04140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z73_04145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8Z73_04150	COG0667	Aldo Keto reductase
H8Z73_04160	COG4771	TonB-dependent receptor
H8Z73_04180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z73_04185	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H8Z73_04195	COG2175	clavaminate synthase activity
H8Z73_04205	COG4181	ATPase activity
H8Z73_04230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H8Z73_04250	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H8Z73_04255	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H8Z73_04270	COG3829	transcription factor binding
H8Z73_04280	COG1116	anion transmembrane transporter activity
H8Z73_04285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z73_04295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z73_04300	COG0431	NADPH-dependent FMN reductase
H8Z73_04325	COG0747	negative chemotaxis
H8Z73_04335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H8Z73_04345	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H8Z73_04350	COG2967	ApaG domain
H8Z73_04355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H8Z73_04360	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H8Z73_04365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z73_04370	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H8Z73_04385	COG0123	including yeast histone deacetylase and acetoin utilization protein
H8Z73_04390	COG2096	Adenosyltransferase
H8Z73_04405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z73_04410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z73_04440	COG3384	dioxygenase
H8Z73_04445	COG0583	DNA-binding transcription factor activity
H8Z73_04460	COG1024	Enoyl-CoA hydratase
H8Z73_04480	COG3386	PFAM SMP-30 Gluconolaconase
H8Z73_04495	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H8Z73_04520	COG0697	spore germination
H8Z73_04525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z73_04545	COG5002	protein histidine kinase activity
H8Z73_04545	COG0784	Response regulator, receiver
H8Z73_04545	COG2205	protein histidine kinase activity
H8Z73_04550	COG2197	response regulator
H8Z73_04560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8Z73_04570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8Z73_04575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z73_04580	COG0583	DNA-binding transcription factor activity
H8Z73_04585	COG3634	alkyl hydroperoxide reductase activity
H8Z73_04595	COG2890	protein-(glutamine-N5) methyltransferase activity
H8Z73_04615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8Z73_04615	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8Z73_04645	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H8Z73_04670	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H8Z73_04685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8Z73_04690	COG1404	Belongs to the peptidase S8 family
H8Z73_04695	COG1404	Belongs to the peptidase S8 family
H8Z73_04700	COG1404	Belongs to the peptidase S8 family
H8Z73_04705	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H8Z73_04730	COG1295	ribonuclease BN
H8Z73_04735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z73_04740	COG1254	Belongs to the acylphosphatase family
H8Z73_04755	COG0521	Mo-molybdopterin cofactor biosynthetic process
H8Z73_04765	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H8Z73_04770	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H8Z73_04780	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H8Z73_04785	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H8Z73_04795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H8Z73_04800	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H8Z73_04805	COG0193	aminoacyl-tRNA hydrolase activity
H8Z73_04810	COG0012	GTP binding
H8Z73_04830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8Z73_04845	COG0250	Participates in transcription elongation, termination and antitermination
H8Z73_04850	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H8Z73_04855	COG0081	regulation of translation
H8Z73_04860	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H8Z73_04865	COG0222	ribosome binding
H8Z73_04870	COG0085	RNA polymerase activity
H8Z73_04875	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8Z73_04880	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H8Z73_04885	COG0049	tRNA binding
H8Z73_04890	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H8Z73_04895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8Z73_04900	COG0051	transcription antitermination factor activity, RNA binding
H8Z73_04905	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H8Z73_04910	COG0088	Forms part of the polypeptide exit tunnel
H8Z73_04915	COG0089	rRNA binding
H8Z73_04920	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H8Z73_04925	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H8Z73_04935	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H8Z73_04940	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H8Z73_04945	COG0255	Belongs to the universal ribosomal protein uL29 family
H8Z73_04950	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H8Z73_04960	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H8Z73_04965	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H8Z73_04975	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H8Z73_04980	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H8Z73_04985	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H8Z73_04995	COG1841	ribosomal large subunit assembly
H8Z73_05000	COG0200	Binds to the 23S rRNA
H8Z73_05005	COG0201	protein transport
H8Z73_05030	COG0203	ribosomal protein L17
H8Z73_05035	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H8Z73_05050	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H8Z73_05060	COG0154	amidase activity
H8Z73_05070	COG1217	gtp-binding protein TYPA
H8Z73_05075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8Z73_05080	COG0039	L-malate dehydrogenase activity
H8Z73_05085	COG0625	glutathione transferase activity
H8Z73_05095	COG1902	pentaerythritol trinitrate reductase activity
H8Z73_05095	COG0446	pyridine nucleotide-disulphide oxidoreductase
H8Z73_05100	COG0604	alcohol dehydrogenase
H8Z73_05125	COG0156	8-amino-7-oxononanoate synthase activity
H8Z73_05130	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H8Z73_05135	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H8Z73_05140	COG4208	sulfate ABC transporter
H8Z73_05145	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H8Z73_05155	COG1063	alcohol dehydrogenase
H8Z73_05185	COG0406	alpha-ribazole phosphatase activity
H8Z73_05190	COG0285	dihydrofolate synthase activity
H8Z73_05210	COG2833	Protein of unknown function (DUF455)
H8Z73_05220	COG3291	Pkd domain containing protein
H8Z73_05230	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z73_05235	COG0671	phosphoesterase, PA-phosphatase related
H8Z73_05240	COG0438	transferase activity, transferring glycosyl groups
H8Z73_05250	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H8Z73_05265	COG4783	chaperone-mediated protein folding
H8Z73_05280	COG0473	3-isopropylmalate dehydrogenase activity
H8Z73_05370	COG2801	Transposase and inactivated derivatives
H8Z73_05395	COG0544	peptidyl-prolyl cis-trans isomerase activity
H8Z73_05405	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H8Z73_05435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z73_05445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z73_05455	COG0328	RNA-DNA hybrid ribonuclease activity
H8Z73_05460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8Z73_05465	COG0631	protein serine/threonine phosphatase activity
H8Z73_05480	COG0859	PFAM glycosyl transferase family 9
H8Z73_05485	COG3642	lipopolysaccharide core region biosynthetic process
H8Z73_05490	COG1234	tRNA 3'-trailer cleavage
H8Z73_05495	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H8Z73_05505	COG0315	cyclic pyranopterin monophosphate synthase activity
H8Z73_05510	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H8Z73_05515	COG0314	molybdopterin synthase activity
H8Z73_05595	COG2003	Belongs to the UPF0758 family
H8Z73_05615	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H8Z73_05685	COG0210	DNA helicase
H8Z73_05730	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H8Z73_05735	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H8Z73_05740	COG0537	adenosine 5'-monophosphoramidase activity
H8Z73_05760	COG0714	Associated with various cellular activities
H8Z73_05780	COG0424	maF-like protein
H8Z73_05785	COG1399	metal-binding, possibly nucleic acid-binding protein
H8Z73_05790	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H8Z73_05795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z73_05810	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_05825	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H8Z73_05830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H8Z73_05855	COG3829	transcription factor binding
H8Z73_05875	COG3609	addiction module antidote protein, CC2985 family
H8Z73_05905	COG2373	Large extracellular alpha-helical protein
H8Z73_05920	COG4953	penicillin-binding protein 1C
H8Z73_05940	COG0678	peroxiredoxin activity
H8Z73_05960	COG0330	HflC and HflK could
H8Z73_05965	COG0330	HflC and HflK could
H8Z73_05975	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H8Z73_05980	COG0308	aminopeptidase N
H8Z73_05985	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_05990	COG1309	transcriptional regulator
H8Z73_06065	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8Z73_06075	COG3387	PFAM Glycoside hydrolase 15-related
H8Z73_06080	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_06085	COG3537	Alpha-1,2-mannosidase
H8Z73_06105	COG0492	ferredoxin-NADP+ reductase activity
H8Z73_06130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H8Z73_06135	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8Z73_06140	COG2080	2 iron, 2 sulfur cluster binding
H8Z73_06175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8Z73_06190	COG0587	DNA-directed DNA polymerase activity
H8Z73_06210	COG1297	OPT oligopeptide transporter protein
H8Z73_06225	COG1506	peptidase
H8Z73_06225	COG0823	Involved in the tonB-independent uptake of proteins
H8Z73_06240	COG2207	Transcriptional regulator
H8Z73_06240	COG1917	Cupin 2, conserved barrel domain protein
H8Z73_06255	COG0753	catalase activity
H8Z73_06260	COG0656	L-ascorbic acid biosynthetic process
H8Z73_06270	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8Z73_06270	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8Z73_06275	COG2814	Major facilitator Superfamily
H8Z73_06290	COG2194	sulfuric ester hydrolase activity
H8Z73_06305	COG0745	RESPONSE REGULATOR receiver
H8Z73_06310	COG0642	Histidine kinase
H8Z73_06320	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H8Z73_06325	COG2894	cell division
H8Z73_06330	COG0850	regulation of cytokinetic process
H8Z73_06340	COG4585	Histidine kinase
H8Z73_06345	COG2197	response regulator
H8Z73_06360	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H8Z73_06385	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H8Z73_06395	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H8Z73_06415	COG1946	Acyl-CoA thioesterase
H8Z73_06430	COG0824	Thioesterase
H8Z73_06435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H8Z73_06440	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H8Z73_06445	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H8Z73_06450	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H8Z73_06455	COG0268	Binds directly to 16S ribosomal RNA
H8Z73_06465	COG0196	riboflavin kinase activity
H8Z73_06470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H8Z73_06475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H8Z73_06480	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H8Z73_06495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H8Z73_06500	COG1845	cytochrome c oxidase, subunit III
H8Z73_06505	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H8Z73_06520	COG3152	Membrane
H8Z73_06530	COG2207	Transcriptional regulator
H8Z73_06545	COG1366	Belongs to the anti-sigma-factor antagonist family
H8Z73_06550	COG1366	Belongs to the anti-sigma-factor antagonist family
H8Z73_06555	COG2172	sigma factor antagonist activity
H8Z73_06580	COG4771	TonB-dependent receptor
H8Z73_06590	COG5507	3-demethylubiquinone-9 3-methyltransferase
H8Z73_06595	COG2205	protein histidine kinase activity
H8Z73_06605	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8Z73_06610	COG4999	Histidine kinase
H8Z73_06610	COG2205	protein histidine kinase activity
H8Z73_06610	COG3437	response regulator, receiver
H8Z73_06610	COG3850	Histidine kinase
H8Z73_06615	COG0784	Response regulator, receiver
H8Z73_06615	COG4191	Histidine kinase
H8Z73_06645	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8Z73_06650	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H8Z73_06660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8Z73_06665	COG0228	four-way junction DNA binding
H8Z73_06670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H8Z73_06675	COG0336	Belongs to the RNA methyltransferase TrmD family
H8Z73_06680	COG0335	large ribosomal subunit rRNA binding
H8Z73_06685	COG0534	Mate efflux family protein
H8Z73_06705	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H8Z73_06715	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H8Z73_06725	COG3209	COG3209 Rhs family protein
H8Z73_06745	COG3250	beta-galactosidase activity
H8Z73_06750	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H8Z73_06770	COG1960	acyl-CoA dehydrogenase activity
H8Z73_06775	COG1024	Enoyl-CoA hydratase
H8Z73_06795	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8Z73_06795	COG1024	Enoyl-CoA hydratase
H8Z73_06810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8Z73_06815	COG0481	GTPase activity
H8Z73_06830	COG0571	ribonuclease III activity
H8Z73_06835	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H8Z73_06840	COG1381	Involved in DNA repair and RecF pathway recombination
H8Z73_06850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8Z73_06855	COG2954	triphosphatase activity
H8Z73_06860	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H8Z73_06865	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
H8Z73_06870	COG3046	protein related to deoxyribodipyrimidine photolyase
H8Z73_06875	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z73_06880	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H8Z73_06885	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H8Z73_06890	COG1278	Cold shock
H8Z73_06895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z73_06905	COG1201	RNA secondary structure unwinding
H8Z73_06910	COG1793	dna ligase
H8Z73_06920	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8Z73_06920	COG1793	dna ligase
H8Z73_06950	COG0183	Belongs to the thiolase family
H8Z73_06975	COG1451	nucleotide metabolic process
H8Z73_06980	COG5487	UPF0391 membrane protein
H8Z73_06990	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H8Z73_07005	COG1077	Cell shape determining protein MreB Mrl
H8Z73_07010	COG1047	Peptidyl-prolyl cis-trans
H8Z73_07015	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H8Z73_07020	COG2824	Alkylphosphonate utilization operon protein PhnA
H8Z73_07025	COG1902	pentaerythritol trinitrate reductase activity
H8Z73_07030	COG2814	Major facilitator Superfamily
H8Z73_07065	COG0392	lysyltransferase activity
H8Z73_07065	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H8Z73_07075	COG0251	oxidation-reduction process
H8Z73_07080	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H8Z73_07095	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H8Z73_07120	COG1595	DNA-templated transcription, initiation
H8Z73_07135	COG2878	Part of a membrane complex involved in electron transport
H8Z73_07145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z73_07145	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z73_07160	COG1131	(ABC) transporter
H8Z73_07165	COG0346	lactoylglutathione lyase activity
H8Z73_07170	COG0833	amino acid
H8Z73_07175	COG2040	homocysteine
H8Z73_07185	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8Z73_07205	COG1695	Transcriptional regulator
H8Z73_07225	COG1981	membrane
H8Z73_07240	COG0825	malonyl-CoA metabolic process
H8Z73_07250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H8Z73_07255	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z73_07260	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z73_07265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z73_07270	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z73_07285	COG0750	zinc metalloprotease
H8Z73_07290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H8Z73_07295	COG0575	Belongs to the CDS family
H8Z73_07300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H8Z73_07305	COG0233	cytoplasmic translational termination
H8Z73_07310	COG0528	UMP kinase activity
H8Z73_07320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H8Z73_07325	COG0052	Belongs to the universal ribosomal protein uS2 family
H8Z73_07365	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H8Z73_07375	COG1393	Belongs to the ArsC family
H8Z73_07380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z73_07385	COG0367	asparagine synthase
H8Z73_07395	COG4774	siderophore transport
H8Z73_07410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8Z73_07440	COG1566	PFAM secretion protein HlyD family protein
H8Z73_07445	COG2814	Major facilitator Superfamily
H8Z73_07495	COG0339	signal peptide processing
H8Z73_07500	COG0386	Belongs to the glutathione peroxidase family
H8Z73_07555	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H8Z73_07560	COG0084	hydrolase, TatD family'
H8Z73_07575	COG1960	acyl-CoA dehydrogenase activity
H8Z73_07590	COG0367	asparagine synthase
H8Z73_07600	COG0305	Participates in initiation and elongation during chromosome replication
H8Z73_07605	COG0415	Belongs to the DNA photolyase family
H8Z73_07615	COG0583	DNA-binding transcription factor activity
H8Z73_07630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z73_07660	COG3706	GGDEF domain
H8Z73_07685	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H8Z73_07700	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z73_07710	COG0497	DNA recombination
H8Z73_07715	COG1420	regulation of RNA biosynthetic process
H8Z73_07720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H8Z73_07725	COG0443	Heat shock 70 kDa protein
H8Z73_07730	COG0484	heat shock protein binding
H8Z73_07740	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H8Z73_07770	COG0583	DNA-binding transcription factor activity
H8Z73_07775	COG1132	(ABC) transporter
H8Z73_07810	COG2850	peptidyl-arginine hydroxylation
H8Z73_07830	COG1253	flavin adenine dinucleotide binding
H8Z73_07860	COG1131	(ABC) transporter
H8Z73_07865	COG1725	Transcriptional regulator
H8Z73_07875	COG0386	Belongs to the glutathione peroxidase family
H8Z73_07890	COG2900	Belongs to the SlyX family
H8Z73_07915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z73_07925	COG1410	methionine synthase
H8Z73_07925	COG0646	methionine synthase
H8Z73_07930	COG1410	methionine synthase
H8Z73_07930	COG0646	methionine synthase
H8Z73_07935	COG2226	methyltransferase
H8Z73_07940	COG1960	acyl-CoA dehydrogenase activity
H8Z73_07945	COG1960	acyl-CoA dehydrogenase activity
H8Z73_07950	COG1960	acyl-CoA dehydrogenase activity
H8Z73_07955	COG1960	acyl-CoA dehydrogenase activity
H8Z73_07970	COG0557	exoribonuclease II activity
H8Z73_07980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8Z73_07990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8Z73_08000	COG0704	Plays a role in the regulation of phosphate uptake
H8Z73_08005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8Z73_08010	COG0581	inorganic phosphate transmembrane transporter activity
H8Z73_08015	COG0573	inorganic phosphate transmembrane transporter activity
H8Z73_08020	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8Z73_08045	COG0659	secondary active sulfate transmembrane transporter activity
H8Z73_08050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H8Z73_08060	COG1024	Enoyl-CoA hydratase
H8Z73_08070	COG0494	nUDIX hydrolase
H8Z73_08105	COG0488	(ABC) transporter
H8Z73_08115	COG0116	Belongs to the methyltransferase superfamily
H8Z73_08115	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H8Z73_08120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8Z73_08145	COG2925	Exonuclease
H8Z73_08155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z73_08160	COG3844	kynureninase activity
H8Z73_08170	COG0662	Cupin 2, conserved barrel domain protein
H8Z73_08175	COG0288	reversible hydration of carbon dioxide
H8Z73_08225	COG3002	Belongs to the UPF0753 family
H8Z73_08250	COG2808	Putative FMN-binding domain
H8Z73_08270	COG0017	Asparaginyl-tRNA synthetase
H8Z73_08275	COG0316	Belongs to the HesB IscA family
H8Z73_08280	COG0360	Binds together with S18 to 16S ribosomal RNA
H8Z73_08285	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H8Z73_08290	COG0359	binds to the 23S rRNA
H8Z73_08300	COG3115	cell septum assembly
H8Z73_08310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z73_08315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8Z73_08320	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H8Z73_08335	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H8Z73_08345	COG4993	Dehydrogenase
H8Z73_08355	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H8Z73_08365	COG2986	histidine ammonia-lyase
H8Z73_08370	COG1228	amidohydrolase
H8Z73_08415	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H8Z73_08420	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H8Z73_08425	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H8Z73_08430	COG0077	Prephenate dehydratase
H8Z73_08430	COG1605	Chorismate mutase
H8Z73_08435	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H8Z73_08450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H8Z73_08455	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8Z73_08460	COG0583	DNA-binding transcription factor activity
H8Z73_08525	COG0840	transmembrane signaling receptor activity
H8Z73_08550	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H8Z73_08555	COG4191	Histidine kinase
H8Z73_08555	COG0784	Response regulator, receiver
H8Z73_08570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z73_08580	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H8Z73_08590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8Z73_08605	COG1595	DNA-templated transcription, initiation
H8Z73_08655	COG2244	polysaccharide biosynthetic process
H8Z73_08685	COG2264	protein methyltransferase activity
H8Z73_08695	COG0438	transferase activity, transferring glycosyl groups
H8Z73_08710	COG1136	(ABC) transporter
H8Z73_08720	COG0477	Major facilitator Superfamily
H8Z73_08725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z73_08740	COG1253	flavin adenine dinucleotide binding
H8Z73_08750	COG0306	phosphate transporter
H8Z73_08775	COG0504	CTP synthase activity
H8Z73_08780	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H8Z73_08790	COG0148	phosphopyruvate hydratase activity
H8Z73_08795	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H8Z73_08800	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H8Z73_08805	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H8Z73_08810	COG0585	pseudouridine synthase activity
H8Z73_08815	COG2840	Smr protein MutS2
H8Z73_08820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H8Z73_08825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H8Z73_08830	COG1238	metal cluster binding
H8Z73_08845	COG1534	Rna-binding protein
H8Z73_08850	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H8Z73_08860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8Z73_08865	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8Z73_08875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H8Z73_08880	COG1546	Belongs to the CinA family
H8Z73_08890	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8Z73_08895	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H8Z73_08900	COG2137	regulation of response to DNA damage stimulus
H8Z73_08905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H8Z73_08910	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H8Z73_08925	COG1741	Belongs to the pirin family
H8Z73_08930	COG0583	DNA-binding transcription factor activity
H8Z73_08955	COG0351	phosphomethylpyrimidine kinase
H8Z73_08955	COG0352	thiamine-phosphate diphosphorylase activity
H8Z73_08970	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H8Z73_08975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8Z73_08990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8Z73_09000	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H8Z73_09005	COG3734	2-keto-3-deoxy-galactonokinase
H8Z73_09015	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z73_09020	COG0800	Aldolase
H8Z73_09055	COG1501	Belongs to the glycosyl hydrolase 31 family
H8Z73_09065	COG1070	Carbohydrate kinase
H8Z73_09070	COG2115	Belongs to the xylose isomerase family
H8Z73_09075	COG0477	Major facilitator Superfamily
H8Z73_09095	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8Z73_09100	COG1469	GTP cyclohydrolase I activity
H8Z73_09120	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H8Z73_09125	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H8Z73_09130	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H8Z73_09135	COG0166	Belongs to the GPI family
H8Z73_09155	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z73_09165	COG4251	negative regulation of phosphorylation
H8Z73_09165	COG5001	Diguanylate cyclase
H8Z73_09165	COG3706	GGDEF domain
H8Z73_09165	COG2203	Gaf domain
H8Z73_09175	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z73_09180	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H8Z73_09190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H8Z73_09195	COG0671	phosphoesterase, PA-phosphatase related
H8Z73_09210	COG1794	racemase activity, acting on amino acids and derivatives
H8Z73_09215	COG0697	spore germination
H8Z73_09220	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H8Z73_09225	COG0167	dihydroorotate dehydrogenase activity
H8Z73_09240	COG1012	belongs to the aldehyde dehydrogenase family
H8Z73_09255	COG1215	transferase activity, transferring glycosyl groups
H8Z73_09260	COG1649	PFAM Uncharacterised BCR, COG1649
H8Z73_09260	COG0726	polysaccharide deacetylase
H8Z73_09275	COG3210	domain, Protein
H8Z73_09345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z73_09350	COG0124	histidyl-tRNA synthetase
H8Z73_09360	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H8Z73_09365	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H8Z73_09370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z73_09375	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H8Z73_09375	COG0131	Imidazoleglycerol-phosphate dehydratase
H8Z73_09380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H8Z73_09385	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H8Z73_09390	COG0107	imidazoleglycerol-phosphate synthase activity
H8Z73_09395	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H8Z73_09395	COG0140	phosphoribosyl-ATP diphosphatase activity
H8Z73_09410	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H8Z73_09415	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H8Z73_09420	COG0235	Class ii aldolase
H8Z73_09425	COG0531	amino acid
H8Z73_09430	COG0531	amino acid
H8Z73_09440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8Z73_09445	COG0277	FAD linked oxidase domain protein
H8Z73_09465	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8Z73_09510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8Z73_09515	COG2258	MOSC domain
H8Z73_09520	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H8Z73_09525	COG0505	Belongs to the CarA family
H8Z73_09535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H8Z73_09540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z73_09550	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H8Z73_09590	COG3279	Response regulator of the LytR AlgR family
H8Z73_09600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8Z73_09610	COG2205	protein histidine kinase activity
H8Z73_09610	COG0784	Response regulator, receiver
H8Z73_09610	COG2198	Histidine kinase
H8Z73_09615	COG1024	Enoyl-CoA hydratase
H8Z73_09650	COG2267	carboxylic ester hydrolase activity
H8Z73_09660	COG2201	protein-glutamate methylesterase activity
H8Z73_09665	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H8Z73_09675	COG0840	transmembrane signaling receptor activity
H8Z73_09685	COG0835	chemotaxis
H8Z73_09695	COG0840	transmembrane signaling receptor activity
H8Z73_09700	COG0840	transmembrane signaling receptor activity
H8Z73_09715	COG0840	transmembrane signaling receptor activity
H8Z73_09720	COG0840	transmembrane signaling receptor activity
H8Z73_09725	COG0840	transmembrane signaling receptor activity
H8Z73_09730	COG0840	transmembrane signaling receptor activity
H8Z73_09735	COG0840	transmembrane signaling receptor activity
H8Z73_09745	COG0840	transmembrane signaling receptor activity
H8Z73_09765	COG2198	Histidine kinase
H8Z73_09765	COG0643	Histidine kinase
H8Z73_09770	COG0745	RESPONSE REGULATOR receiver
H8Z73_09780	COG0835	chemotaxis
H8Z73_09790	COG1360	Flagellar Motor Protein
H8Z73_09795	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H8Z73_09835	COG0641	radical SAM
H8Z73_09845	COG0643	Histidine kinase
H8Z73_09845	COG2198	Histidine kinase
H8Z73_09845	COG0784	Response regulator, receiver
H8Z73_09875	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8Z73_09900	COG1684	flagellar biosynthetic protein fliR
H8Z73_09915	COG3190	flagellar
H8Z73_09965	COG1677	Flagellar hook-basal body complex protein FliE
H8Z73_09995	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_10000	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_10005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z73_10025	COG2201	protein-glutamate methylesterase activity
H8Z73_10055	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H8Z73_10065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8Z73_10070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8Z73_10080	COG1705	Flagellar rod assembly protein muramidase FlgJ
H8Z73_10080	COG3951	Flagellar rod assembly protein muramidase FlgJ
H8Z73_10085	COG1706	bacterial-type flagellum-dependent cell motility
H8Z73_10090	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H8Z73_10105	COG4787	bacterial-type flagellum-dependent cell motility
H8Z73_10115	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H8Z73_10120	COG1558	bacterial-type flagellum-dependent cell motility
H8Z73_10130	COG0784	Response regulator, receiver
H8Z73_10130	COG0835	chemotaxis
H8Z73_10150	COG5002	protein histidine kinase activity
H8Z73_10180	COG2915	High frequency lysogenization protein hflD homolog
H8Z73_10185	COG0482	sulfurtransferase activity
H8Z73_10200	COG0542	response to heat
H8Z73_10210	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H8Z73_10220	COG0492	ferredoxin-NADP+ reductase activity
H8Z73_10225	COG1674	ftsk spoiiie
H8Z73_10235	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H8Z73_10245	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H8Z73_10250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8Z73_10255	COG0183	Belongs to the thiolase family
H8Z73_10260	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8Z73_10260	COG1024	Enoyl-CoA hydratase
H8Z73_10275	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H8Z73_10285	COG1426	Protein conserved in bacteria
H8Z73_10295	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z73_10300	COG1160	GTP binding
H8Z73_10305	COG0303	'Molybdopterin
H8Z73_10310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H8Z73_10345	COG0708	Exodeoxyribonuclease III
H8Z73_10355	COG0303	'Molybdopterin
H8Z73_10360	COG0746	molybdenum cofactor guanylyltransferase activity
H8Z73_10375	COG1914	H( )-stimulated, divalent metal cation uptake system
H8Z73_10390	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H8Z73_10395	COG0668	transmembrane transport
H8Z73_10405	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H8Z73_10420	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_10425	COG1183	phosphatidylcholine synthase activity
H8Z73_10435	COG3243	poly(R)-hydroxyalkanoic acid synthase
H8Z73_10450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z73_10450	COG0723	plastoquinol--plastocyanin reductase activity
H8Z73_10460	COG2183	response to ionizing radiation
H8Z73_10470	COG0784	Response regulator, receiver
H8Z73_10470	COG2205	protein histidine kinase activity
H8Z73_10535	COG0800	Aldolase
H8Z73_10540	COG0129	dihydroxy-acid dehydratase activity
H8Z73_10545	COG0363	glucosamine-6-phosphate deaminase activity
H8Z73_10550	COG0837	glucose binding
H8Z73_10555	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8Z73_10580	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H8Z73_10595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H8Z73_10600	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H8Z73_10610	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8Z73_10615	COG1136	(ABC) transporter
H8Z73_10630	COG0811	peptide transport
H8Z73_10640	COG1132	(ABC) transporter
H8Z73_10645	COG1663	tetraacyldisaccharide 4'-kinase activity
H8Z73_10650	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H8Z73_10655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8Z73_10665	COG0322	excinuclease ABC activity
H8Z73_10670	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8Z73_10680	COG0582	viral genome integration into host DNA
H8Z73_10685	COG2801	Transposase and inactivated derivatives
H8Z73_10785	COG2003	Belongs to the UPF0758 family
H8Z73_10960	COG0270	DNA (cytosine-5-)-methyltransferase activity
H8Z73_10965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z73_10970	COG0629	single-stranded DNA binding
H8Z73_11105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z73_11110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z73_11125	COG0582	viral genome integration into host DNA
H8Z73_11135	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H8Z73_11155	COG1054	Belongs to the UPF0176 family
H8Z73_11165	COG1530	ribonuclease E activity
H8Z73_11175	COG3064	Membrane
H8Z73_11180	COG0428	transporter
H8Z73_11190	COG2154	pterin-4-alpha-carbinolamine dehydratase
H8Z73_11195	COG0316	Belongs to the HesB IscA family
H8Z73_11195	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H8Z73_11240	COG1073	alpha beta
H8Z73_11240	COG2226	methyltransferase
H8Z73_11250	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_11280	COG1238	metal cluster binding
H8Z73_11315	COG3279	Response regulator of the LytR AlgR family
H8Z73_11355	COG4566	intracellular signal transduction
H8Z73_11365	COG5001	Diguanylate cyclase
H8Z73_11385	COG3685	Protein conserved in bacteria
H8Z73_11410	COG1648	precorrin-2 dehydrogenase activity
H8Z73_11410	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8Z73_11425	COG2814	Major facilitator Superfamily
H8Z73_11440	COG1335	isochorismatase
H8Z73_11460	COG2197	response regulator
H8Z73_11480	COG0583	DNA-binding transcription factor activity
H8Z73_11485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8Z73_11490	COG3002	Belongs to the UPF0753 family
H8Z73_11495	COG2801	Transposase and inactivated derivatives
H8Z73_11500	COG1396	sequence-specific DNA binding
H8Z73_11505	COG5489	Protein of unknown function (DUF736)
H8Z73_11515	COG2003	Belongs to the UPF0758 family
H8Z73_11545	COG0582	viral genome integration into host DNA
H8Z73_11560	COG4774	siderophore transport
H8Z73_11590	COG2336	PFAM SpoVT AbrB
H8Z73_11615	COG4206	TonB-dependent receptor
H8Z73_11655	COG2274	protein secretion by the type I secretion system
H8Z73_11710	COG0270	DNA (cytosine-5-)-methyltransferase activity
H8Z73_11850	COG2084	Dehydrogenase
H8Z73_11870	COG2003	Belongs to the UPF0758 family
H8Z73_11905	COG0582	viral genome integration into host DNA
H8Z73_11910	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z73_11910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8Z73_11920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H8Z73_11930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8Z73_11930	COG0475	glutathione-regulated potassium exporter activity
H8Z73_11935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H8Z73_11945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8Z73_11950	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H8Z73_11960	COG0776	regulation of translation
H8Z73_11965	COG0539	negative regulation of cytoplasmic translation
H8Z73_11970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H8Z73_11985	COG2957	Belongs to the agmatine deiminase family
H8Z73_11990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8Z73_12015	COG0395	ABC-type sugar transport system, permease component
H8Z73_12020	COG1175	transmembrane transport
H8Z73_12050	COG2350	Protein conserved in bacteria
H8Z73_12055	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H8Z73_12060	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H8Z73_12065	COG1187	pseudouridine synthase activity
H8Z73_12085	COG0436	Aminotransferase
H8Z73_12090	COG4133	protoheme IX ABC transporter activity
H8Z73_12110	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H8Z73_12115	COG1138	Cytochrome C-type biogenesis protein
H8Z73_12135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z73_12140	COG1278	Cold shock
H8Z73_12145	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H8Z73_12150	COG4988	ABC transporter
H8Z73_12170	COG1294	oxidase, subunit
H8Z73_12195	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H8Z73_12205	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H8Z73_12215	COG0165	Argininosuccinate lyase
H8Z73_12220	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H8Z73_12230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H8Z73_12235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z73_12245	COG0137	argininosuccinate synthase activity
H8Z73_12250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H8Z73_12260	COG0215	cysteine-tRNA ligase activity
H8Z73_12265	COG2166	iron-sulfur cluster assembly
H8Z73_12280	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H8Z73_12285	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H8Z73_12315	COG4302	ethanolamine ammonia-lyase activity
H8Z73_12370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8Z73_12375	COG0402	S-adenosylhomocysteine deaminase activity
H8Z73_12385	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8Z73_12390	COG1509	lysine 2,3-aminomutase activity
H8Z73_12395	COG3300	MHYT domain
H8Z73_12395	COG5001	Diguanylate cyclase
H8Z73_12410	COG0483	inositol monophosphate 1-phosphatase activity
H8Z73_12415	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8Z73_12430	COG0488	(ABC) transporter
H8Z73_12435	COG0513	Belongs to the DEAD box helicase family
H8Z73_12440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8Z73_12445	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H8Z73_12460	COG0625	glutathione transferase activity
H8Z73_12470	COG4681	YaeQ
H8Z73_12475	COG2081	HI0933 family
H8Z73_12485	COG0501	Belongs to the peptidase M48B family
H8Z73_12490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z73_12495	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_12520	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H8Z73_12525	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8Z73_12530	COG0802	atpase or kinase
H8Z73_12535	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H8Z73_12535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8Z73_12540	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8Z73_12545	COG1570	exodeoxyribonuclease VII activity
H8Z73_12555	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8Z73_12745	COG0835	chemotaxis
H8Z73_12750	COG0840	transmembrane signaling receptor activity
H8Z73_12755	COG2094	Belongs to the DNA glycosylase MPG family
H8Z73_12760	COG1201	RNA secondary structure unwinding
H8Z73_12780	COG2969	positive regulation of protein catabolic process
H8Z73_12785	COG0625	glutathione transferase activity
H8Z73_12790	COG2857	Cytochrome c1
H8Z73_12795	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8Z73_12800	COG0723	plastoquinol--plastocyanin reductase activity
H8Z73_12805	COG0741	lytic transglycosylase activity
H8Z73_12820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8Z73_12825	COG1702	phosphate starvation-inducible protein PhoH
H8Z73_12835	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H8Z73_12845	COG4535	Mg2 and Co2 transporter CorC
H8Z73_12860	COG1012	belongs to the aldehyde dehydrogenase family
H8Z73_12865	COG1177	transmembrane transport
H8Z73_12870	COG1176	ABC-type spermidine putrescine transport system, permease component I
H8Z73_12875	COG3842	ATPase activity
H8Z73_12895	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H8Z73_12910	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H8Z73_12915	COG0174	glutamine synthetase
H8Z73_12920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z73_12930	COG2703	oxygen carrier activity
H8Z73_12935	COG0477	Major facilitator Superfamily
H8Z73_12945	COG0243	molybdopterin cofactor binding
H8Z73_12950	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H8Z73_12955	COG2223	nitrite transmembrane transporter activity
H8Z73_12960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H8Z73_12970	COG2733	membrane
H8Z73_12975	COG5002	protein histidine kinase activity
H8Z73_12975	COG2205	protein histidine kinase activity
H8Z73_12975	COG0784	Response regulator, receiver
H8Z73_12985	COG0477	Major facilitator Superfamily
H8Z73_12995	COG2902	Dehydrogenase
H8Z73_13005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z73_13010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z73_13015	COG1609	Transcriptional regulator
H8Z73_13020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8Z73_13020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z73_13025	COG1105	Belongs to the carbohydrate kinase PfkB family
H8Z73_13030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8Z73_13030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8Z73_13070	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8Z73_13080	COG1862	Preprotein translocase
H8Z73_13085	COG0343	queuine tRNA-ribosyltransferase activity
H8Z73_13090	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H8Z73_13125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H8Z73_13130	COG3291	Pkd domain containing protein
H8Z73_13135	COG0405	Gamma-glutamyltransferase
H8Z73_13140	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8Z73_13150	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H8Z73_13155	COG0742	ribosomal rna small subunit methyltransferase
H8Z73_13160	COG0326	Molecular chaperone. Has ATPase activity
H8Z73_13235	COG0531	amino acid
H8Z73_13250	COG0006	proline dipeptidase activity
H8Z73_13260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8Z73_13275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z73_13280	COG3938	Belongs to the proline racemase family
H8Z73_13290	COG0552	protein localization to endoplasmic reticulum
H8Z73_13295	COG1194	a g-specific adenine glycosylase
H8Z73_13300	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H8Z73_13305	COG0784	Response regulator, receiver
H8Z73_13305	COG4191	Histidine kinase
H8Z73_13320	COG0322	excinuclease ABC activity
H8Z73_13335	COG3040	lipid binding
H8Z73_13350	COG1960	acyl-CoA dehydrogenase activity
H8Z73_13360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H8Z73_13380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z73_13385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z73_13390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z73_13415	COG0438	transferase activity, transferring glycosyl groups
H8Z73_13425	COG0438	transferase activity, transferring glycosyl groups
H8Z73_13430	COG0438	transferase activity, transferring glycosyl groups
H8Z73_13480	COG0072	phenylalanine-tRNA ligase activity
H8Z73_13480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z73_13485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H8Z73_13500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H8Z73_13505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H8Z73_13530	COG1082	Xylose isomerase domain protein TIM barrel
H8Z73_13620	COG3702	type iv secretory pathway
H8Z73_13640	COG2948	multi-organism process
H8Z73_13660	COG3505	Type IV secretory pathway VirD4
H8Z73_13675	COG0556	nucleotide-excision repair
H8Z73_13760	COG4695	Portal protein
H8Z73_13805	COG3179	chitinase
H8Z73_13860	COG3275	phosphorelay sensor kinase activity
H8Z73_13865	COG1611	Belongs to the LOG family
H8Z73_13875	COG2095	MarC family integral membrane protein
H8Z73_13885	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8Z73_13920	COG1185	polyribonucleotide nucleotidyltransferase activity
H8Z73_13925	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H8Z73_13930	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H8Z73_13935	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H8Z73_13940	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H8Z73_13945	COG0195	Participates in both transcription termination and antitermination
H8Z73_13950	COG0779	Required for maturation of 30S ribosomal subunits
H8Z73_13960	COG1007	ATP synthesis coupled electron transport
H8Z73_13985	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z73_13990	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H8Z73_14000	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H8Z73_14005	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H8Z73_14010	COG0649	NAD binding
H8Z73_14015	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z73_14020	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z73_14025	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z73_14040	COG0149	triose-phosphate isomerase activity
H8Z73_14045	COG0300	oxidoreductase activity
H8Z73_14075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8Z73_14080	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H8Z73_14085	COG0159	tryptophan synthase activity
H8Z73_14095	COG0133	tryptophan synthase activity
H8Z73_14105	COG0135	phosphoribosylanthranilate isomerase activity
H8Z73_14110	COG0101	tRNA pseudouridine synthase activity
H8Z73_14130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H8Z73_14135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8Z73_14140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H8Z73_14145	COG2890	protein-(glutamine-N5) methyltransferase activity
H8Z73_14155	COG0688	phosphatidylethanolamine metabolic process
H8Z73_14165	COG0433	COG0433 Predicted ATPase
H8Z73_14170	COG0494	nUDIX hydrolase
H8Z73_14185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z73_14190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8Z73_14215	COG0717	Belongs to the dCTP deaminase family
H8Z73_14220	COG0489	protein tyrosine kinase activity
H8Z73_14240	COG3590	peptidase
H8Z73_14245	COG3590	peptidase
H8Z73_14265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8Z73_14270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z73_14275	COG2311	Membrane
H8Z73_14280	COG1047	Peptidyl-prolyl cis-trans
H8Z73_14285	COG0791	NLP P60 protein
H8Z73_14290	COG0791	NLP P60 protein
H8Z73_14300	COG4106	trans-aconitate 2-methyltransferase activity
H8Z73_14305	COG1301	dicarboxylic acid transport
H8Z73_14310	COG1785	Belongs to the alkaline phosphatase family
H8Z73_14315	COG0037	tRNA processing
H8Z73_14320	COG1722	exodeoxyribonuclease VII activity
H8Z73_14325	COG0142	geranyltranstransferase activity
H8Z73_14330	COG4104	PAAR repeat-containing protein
H8Z73_14340	COG0312	modulator of DNA gyrase
H8Z73_14345	COG3028	Belongs to the UPF0307 family
H8Z73_14350	COG0312	modulator of DNA gyrase
H8Z73_14360	COG3164	Protein of unknown function
H8Z73_14370	COG0424	maF-like protein
H8Z73_14375	COG2968	Membrane
H8Z73_14390	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H8Z73_14405	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H8Z73_14420	COG0495	leucyl-tRNA aminoacylation
H8Z73_14430	COG3118	belongs to the thioredoxin family
H8Z73_14455	COG2155	Conserved Protein
H8Z73_14500	COG1132	(ABC) transporter
H8Z73_14530	COG1538	Outer membrane efflux protein
H8Z73_14535	COG0745	RESPONSE REGULATOR receiver
H8Z73_14540	COG5002	protein histidine kinase activity
H8Z73_14540	COG5000	phosphorelay sensor kinase activity
H8Z73_14545	COG0475	glutathione-regulated potassium exporter activity
H8Z73_14555	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H8Z73_14575	COG1187	pseudouridine synthase activity
H8Z73_14580	COG5002	protein histidine kinase activity
H8Z73_14580	COG5001	Diguanylate cyclase
H8Z73_14700	COG0667	Aldo Keto reductase
H8Z73_14705	COG2814	Major facilitator Superfamily
H8Z73_14710	COG0583	DNA-binding transcription factor activity
H8Z73_14720	COG2207	Transcriptional regulator
H8Z73_14730	COG1309	transcriptional regulator
H8Z73_14740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z73_14755	COG0735	belongs to the Fur family
H8Z73_14760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z73_14785	COG4452	Inner membrane protein CreD
H8Z73_14800	COG2205	protein histidine kinase activity
H8Z73_14805	COG0745	RESPONSE REGULATOR receiver
H8Z73_14810	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H8Z73_14820	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H8Z73_14850	COG2198	Histidine kinase
H8Z73_14850	COG0643	Histidine kinase
H8Z73_14855	COG0840	transmembrane signaling receptor activity
H8Z73_14860	COG0835	chemotaxis
H8Z73_14865	COG2200	EAL domain
H8Z73_14865	COG2199	diguanylate cyclase activity
H8Z73_14865	COG2202	Pas domain
H8Z73_14870	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8Z73_14875	COG2201	protein-glutamate methylesterase activity
H8Z73_14880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z73_14885	COG3590	peptidase
H8Z73_14895	COG0588	phosphoglycerate mutase activity
H8Z73_14900	COG1515	deoxyribonuclease V activity
H8Z73_14910	COG1741	Belongs to the pirin family
H8Z73_14925	COG1741	Belongs to the pirin family
H8Z73_14930	COG1966	Carbon starvation protein
H8Z73_14935	COG2879	small protein
H8Z73_14970	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H8Z73_14975	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H8Z73_14980	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8Z73_15000	COG4251	negative regulation of phosphorylation
H8Z73_15000	COG3706	GGDEF domain
H8Z73_15000	COG5001	Diguanylate cyclase
H8Z73_15000	COG2203	Gaf domain
H8Z73_15005	COG0629	single-stranded DNA binding
H8Z73_15010	COG0142	geranyltranstransferase activity
H8Z73_15020	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H8Z73_15035	COG0527	aspartate kinase activity
H8Z73_15040	COG0384	phenazine biosynthesis protein PhzF
H8Z73_15045	COG0384	phenazine biosynthesis protein PhzF
H8Z73_15055	COG1764	response to oxidative stress
H8Z73_15060	COG0540	Belongs to the ATCase OTCase family
H8Z73_15065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H8Z73_15070	COG1678	Uncharacterized ACR, COG1678
H8Z73_15075	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z73_15090	COG5297	Belongs to the glycosyl hydrolase family 6
H8Z73_15105	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H8Z73_15120	COG0739	heme binding
H8Z73_15140	COG0693	protein deglycase activity
H8Z73_15150	COG1959	2 iron, 2 sulfur cluster binding
H8Z73_15155	COG0719	Fe-S assembly protein
H8Z73_15160	COG0396	ATPase activity
H8Z73_15165	COG0719	Fe-S assembly protein
H8Z73_15170	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H8Z73_15180	COG2146	nitrite reductase [NAD(P)H] activity
H8Z73_15185	COG4774	siderophore transport
H8Z73_15190	COG3128	pkhd-type hydroxylase
H8Z73_15215	COG1477	protein flavinylation
H8Z73_15220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8Z73_15235	COG1555	photosystem II stabilization
H8Z73_15240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z73_15250	COG3178	'Phosphotransferase
H8Z73_15255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H8Z73_15265	COG0628	permease
H8Z73_15275	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H8Z73_15285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H8Z73_15305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H8Z73_15310	COG0271	Belongs to the BolA IbaG family
H8Z73_15320	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H8Z73_15330	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H8Z73_15335	COG1137	ATPase activity
H8Z73_15350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z73_15355	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H8Z73_15360	COG1660	Displays ATPase and GTPase activities
H8Z73_15370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z73_15375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8Z73_15380	COG2239	Acts as a magnesium transporter
H8Z73_15395	COG1294	oxidase, subunit
H8Z73_15400	COG1271	oxidase subunit
H8Z73_15410	COG1113	amino acid transport
H8Z73_15430	COG2197	response regulator
H8Z73_15440	COG0531	amino acid
H8Z73_15460	COG1234	tRNA 3'-trailer cleavage
H8Z73_15495	COG2814	Major facilitator Superfamily
H8Z73_15505	COG0754	glutathionylspermidine amidase activity
H8Z73_15530	COG1842	Phage shock protein A
H8Z73_15540	COG0259	pyridoxamine-phosphate oxidase activity
H8Z73_15545	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H8Z73_15550	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H8Z73_15560	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H8Z73_15640	COG0477	Major facilitator Superfamily
H8Z73_15660	COG2205	protein histidine kinase activity
H8Z73_15660	COG2198	Histidine kinase
H8Z73_15660	COG0784	Response regulator, receiver
H8Z73_15665	COG2353	YceI-like domain
H8Z73_15685	COG1760	l-serine dehydratase
H8Z73_15695	COG0527	aspartate kinase activity
H8Z73_15695	COG0460	homoserine dehydrogenase
H8Z73_15700	COG0626	cystathionine gamma-synthase activity
H8Z73_15705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z73_15710	COG0739	heme binding
H8Z73_15715	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H8Z73_15720	COG1272	protein, Hemolysin III
H8Z73_15725	COG2982	Protein involved in outer membrane biogenesis
H8Z73_15730	COG0516	GMP reductase activity
H8Z73_15730	COG0517	IMP dehydrogenase activity
H8Z73_15735	COG0463	Glycosyl transferase, family 2
H8Z73_15740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8Z73_15745	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H8Z73_15755	COG4771	TonB-dependent receptor
H8Z73_15775	COG1309	transcriptional regulator
H8Z73_15785	COG1960	acyl-CoA dehydrogenase activity
H8Z73_15815	COG0509	glycine decarboxylation via glycine cleavage system
H8Z73_15820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H8Z73_15830	COG0330	HflC and HflK could
H8Z73_15835	COG1742	UPF0060 membrane protein
H8Z73_15840	COG3956	TIGRFAM MazG family protein
H8Z73_15850	COG0494	nUDIX hydrolase
H8Z73_15860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H8Z73_15865	COG0837	glucose binding
H8Z73_15880	COG1388	LysM domain
H8Z73_15880	COG3858	chitin binding
H8Z73_15885	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H8Z73_15895	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z73_15910	COG0531	amino acid
H8Z73_15920	COG1486	melibiose metabolic process
H8Z73_15930	COG3537	Alpha-1,2-mannosidase
H8Z73_15965	COG3142	Participates in the control of copper homeostasis
H8Z73_15970	COG1446	asparaginase
H8Z73_15990	COG2198	Histidine kinase
H8Z73_15990	COG0643	Histidine kinase
H8Z73_15990	COG0784	Response regulator, receiver
H8Z73_15995	COG0840	transmembrane signaling receptor activity
H8Z73_16000	COG0835	chemotaxis
H8Z73_16015	COG0189	ligase activity
H8Z73_16025	COG1397	ADP-ribosylglycohydrolase
H8Z73_16035	COG1199	ATP-dependent helicase activity
H8Z73_16045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8Z73_16050	COG1215	transferase activity, transferring glycosyl groups
H8Z73_16060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8Z73_16070	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H8Z73_16075	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
H8Z73_16080	COG0535	radical SAM domain protein
H8Z73_16085	COG0535	radical SAM domain protein
H8Z73_16100	COG0837	glucose binding
H8Z73_16115	COG1643	Atp-dependent helicase
H8Z73_16120	COG0783	Belongs to the Dps family
H8Z73_16125	COG0514	ATP-dependent DNA helicase (RecQ)
H8Z73_16155	COG0840	transmembrane signaling receptor activity
H8Z73_16175	COG3920	Histidine kinase
H8Z73_16180	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H8Z73_16190	COG0602	queuosine metabolic process
H8Z73_16200	COG2885	chlorophyll binding
H8Z73_16205	COG0823	Involved in the tonB-independent uptake of proteins
H8Z73_16215	COG0848	biopolymer transport protein
H8Z73_16225	COG0824	Thioesterase
H8Z73_16230	COG2255	four-way junction helicase activity
H8Z73_16240	COG3158	transport of potassium into the cell
H8Z73_16245	COG0632	four-way junction helicase activity
H8Z73_16250	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H8Z73_16255	COG0217	transcriptional regulatory protein
H8Z73_16270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H8Z73_16285	COG0477	Major facilitator Superfamily
H8Z73_16325	COG0488	(ABC) transporter
H8Z73_16355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8Z73_16355	COG4651	solute:proton antiporter activity
H8Z73_16380	COG4772	TonB-dependent receptor
H8Z73_16390	COG4264	IucA IucC family
H8Z73_16405	COG0019	diaminopimelate decarboxylase activity
H8Z73_16435	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H8Z73_16445	COG1492	cobalamin metabolic process
H8Z73_16455	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8Z73_16475	COG4206	TonB-dependent receptor
H8Z73_16480	COG0542	response to heat
H8Z73_16485	COG1116	anion transmembrane transporter activity
H8Z73_16490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z73_16495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H8Z73_16500	COG0667	Aldo Keto reductase
H8Z73_16505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z73_16510	COG4771	TonB-dependent receptor
H8Z73_16515	COG2827	Endonuclease containing a URI domain
H8Z73_16555	COG1877	trehalose-phosphatase activity
H8Z73_16560	COG3387	PFAM Glycoside hydrolase 15-related
H8Z73_16575	COG0840	transmembrane signaling receptor activity
H8Z73_16580	COG3011	Protein conserved in bacteria
H8Z73_16595	COG0564	pseudouridine synthase activity
H8Z73_16600	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z73_16610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8Z73_16610	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H8Z73_16630	COG2951	lytic endotransglycosylase activity
H8Z73_16635	COG4644	lycopene metabolic process
H8Z73_16660	COG2369	cell adhesion
H8Z73_16680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H8Z73_16685	COG0045	succinate-CoA ligase (ADP-forming) activity
H8Z73_16700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z73_16730	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H8Z73_16735	COG0237	dephospho-CoA kinase activity
H8Z73_16770	COG5002	protein histidine kinase activity
H8Z73_16775	COG0745	RESPONSE REGULATOR receiver
H8Z73_16920	COG2022	thiamine diphosphate biosynthetic process
H8Z73_16930	COG3273	potassium ion transport
H8Z73_16930	COG0471	metal ion transport
H8Z73_16950	COG1970	mechanosensitive ion channel activity
H8Z73_16970	COG3250	beta-galactosidase activity
H8Z73_16975	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z73_16990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8Z73_17000	COG0308	aminopeptidase N
H8Z73_17035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z73_17045	COG0529	Catalyzes the synthesis of activated sulfate
H8Z73_17045	COG2895	sulfate adenylyltransferase (ATP) activity
H8Z73_17050	COG0175	sulfate reduction
H8Z73_17055	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8Z73_17060	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8Z73_17065	COG0175	sulfate reduction
H8Z73_17085	COG0784	Response regulator, receiver
H8Z73_17085	COG2198	Histidine kinase
H8Z73_17085	COG2205	protein histidine kinase activity
H8Z73_17100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8Z73_17100	COG1648	precorrin-2 dehydrogenase activity
H8Z73_17115	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H8Z73_17120	COG3588	fructose-bisphosphate aldolase
H8Z73_17125	COG0469	pyruvate kinase activity
H8Z73_17135	COG0126	phosphoglycerate kinase activity
H8Z73_17155	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8Z73_17165	COG3047	cAMP biosynthetic process
H8Z73_17170	COG3047	cAMP biosynthetic process
H8Z73_17180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z73_17180	COG3453	Protein conserved in bacteria
H8Z73_17185	COG0725	ABC transporter, periplasmic molybdate-binding protein
H8Z73_17190	COG4149	molybdate abc transporter
H8Z73_17195	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H8Z73_17230	COG1376	ErfK ybiS ycfS ynhG family protein
H8Z73_17235	COG0739	heme binding
H8Z73_17245	COG4773	Receptor
H8Z73_17250	COG0596	Alpha beta hydrolase
H8Z73_17255	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H8Z73_17260	COG1301	dicarboxylic acid transport
H8Z73_17270	COG2304	oxidoreductase activity
H8Z73_17290	COG0714	Associated with various cellular activities
H8Z73_17320	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H8Z73_17345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8Z73_17355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8Z73_17365	COG0194	GDP metabolic process
H8Z73_17370	COG1561	YicC-like family, N-terminal region
H8Z73_17375	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H8Z73_17385	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8Z73_17390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8Z73_17405	COG0006	proline dipeptidase activity
H8Z73_17415	COG0006	proline dipeptidase activity
H8Z73_17420	COG3079	Belongs to the UPF0149 family
H8Z73_17440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H8Z73_17450	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H8Z73_17460	COG2912	Transglutaminase-like superfamily
H8Z73_17465	COG1773	rubredoxin
H8Z73_17470	COG0352	thiamine-phosphate diphosphorylase activity
H8Z73_17485	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8Z73_17500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z73_17530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8Z73_17535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z73_17545	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_17555	COG0671	phosphoesterase, PA-phosphatase related
H8Z73_17560	COG3781	membrane
H8Z73_17570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8Z73_17575	COG0563	adenylate kinase activity
H8Z73_17590	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H8Z73_17600	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H8Z73_17620	COG3710	Transcriptional regulator
H8Z73_17625	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H8Z73_17635	COG0840	transmembrane signaling receptor activity
H8Z73_17640	COG0405	Gamma-glutamyltransferase
H8Z73_17645	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H8Z73_17665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H8Z73_17670	COG0473	3-isopropylmalate dehydrogenase activity
H8Z73_17675	COG0066	3-isopropylmalate dehydratase activity
H8Z73_17680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H8Z73_17700	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H8Z73_17705	COG1538	Outer membrane efflux protein
H8Z73_17710	COG1519	Transferase
H8Z73_17715	COG1560	Kdo2-lipid A biosynthetic process
H8Z73_17740	COG0281	malic enzyme
H8Z73_17740	COG0280	phosphate acetyltransferase
H8Z73_17745	COG1301	dicarboxylic acid transport
H8Z73_17770	COG0583	DNA-binding transcription factor activity
H8Z73_17775	COG0667	Aldo Keto reductase
H8Z73_17790	COG2197	response regulator
H8Z73_17800	COG0642	Histidine kinase
H8Z73_17815	COG2851	Citrate transporter
H8Z73_17820	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_17825	COG1609	Transcriptional regulator
H8Z73_17830	COG2211	Major facilitator Superfamily
H8Z73_17855	COG1162	GTPase activity
H8Z73_17875	COG4773	Receptor
H8Z73_17880	COG0726	polysaccharide deacetylase
H8Z73_17885	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8Z73_17915	COG1307	EDD domain protein, DegV family
H8Z73_17920	COG0242	peptide deformylase activity
H8Z73_17940	COG0457	Tetratricopeptide repeat
H8Z73_17945	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H8Z73_17950	COG1215	transferase activity, transferring glycosyl groups
H8Z73_17955	COG1215	transferase activity, transferring glycosyl groups
H8Z73_17970	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H8Z73_18015	COG2188	Transcriptional regulator
H8Z73_18030	COG1450	Type ii and iii secretion system protein
H8Z73_18045	COG3166	PFAM Fimbrial assembly family protein
H8Z73_18050	COG3156	type II secretion system protein K
H8Z73_18055	COG4795	General secretion pathway protein
H8Z73_18060	COG2165	general secretion pathway protein
H8Z73_18065	COG4970	Tfp pilus assembly protein FimT
H8Z73_18070	COG2165	general secretion pathway protein
H8Z73_18075	COG1459	type II secretion system
H8Z73_18080	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z73_18085	COG1404	Belongs to the peptidase S8 family
H8Z73_18090	COG5295	Hep Hag repeat protein
H8Z73_18095	COG1404	Belongs to the peptidase S8 family
H8Z73_18100	COG5295	Hep Hag repeat protein
H8Z73_18105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H8Z73_18105	COG0047	phosphoribosylformylglycinamidine synthase activity
H8Z73_18110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8Z73_18115	COG4974	Belongs to the 'phage' integrase family
H8Z73_18130	COG0795	lipopolysaccharide-transporting ATPase activity
H8Z73_18140	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8Z73_18155	COG0525	valine-tRNA ligase activity
H8Z73_18190	COG1183	phosphatidylcholine synthase activity
H8Z73_18200	COG0442	prolyl-tRNA aminoacylation
H8Z73_18215	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8Z73_18220	COG1127	ABC transporter
H8Z73_18225	COG3218	ABC-type transport auxiliary lipoprotein component
H8Z73_18225	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8Z73_18260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8Z73_18265	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H8Z73_18265	COG0662	Cupin 2, conserved barrel domain protein
H8Z73_18295	COG2086	electron transfer activity
H8Z73_18310	COG0546	phosphoglycolate phosphatase activity
H8Z73_18310	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8Z73_18315	COG0277	FAD linked oxidase domain protein
H8Z73_18320	COG0300	oxidoreductase activity
H8Z73_18330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z73_18350	COG2226	methyltransferase
H8Z73_18360	COG3754	Rhamnan synthesis protein F
H8Z73_18365	COG1216	Glycosyl transferase, family 2
H8Z73_18365	COG0438	transferase activity, transferring glycosyl groups
H8Z73_18370	COG0110	maltose O-acetyltransferase activity
H8Z73_18385	COG0626	cystathionine gamma-synthase activity
H8Z73_18415	COG0625	glutathione transferase activity
H8Z73_18425	COG0513	Belongs to the DEAD box helicase family
H8Z73_18435	COG4206	TonB-dependent receptor
H8Z73_18440	COG0720	synthase
H8Z73_18450	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H8Z73_18455	COG1956	GAF domain-containing protein
H8Z73_18465	COG2819	hydrolase of the alpha beta superfamily
H8Z73_18480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8Z73_18485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z73_18500	COG0339	signal peptide processing
H8Z73_18555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8Z73_18560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z73_18565	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8Z73_18565	COG1136	(ABC) transporter
H8Z73_18570	COG0577	efflux transmembrane transporter activity
H8Z73_18575	COG0577	efflux transmembrane transporter activity
H8Z73_18590	COG4191	Histidine kinase
H8Z73_18595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8Z73_18610	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H8Z73_18615	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H8Z73_18620	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H8Z73_18625	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H8Z73_18630	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H8Z73_18635	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8Z73_18645	COG0356	it plays a direct role in the translocation of protons across the membrane
H8Z73_18665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8Z73_18675	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8Z73_18715	COG2011	ABC-type metal ion transport system permease component
H8Z73_18720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H8Z73_18725	COG0697	spore germination
H8Z73_18730	COG1666	GTP binding
H8Z73_18740	COG2198	Histidine kinase
H8Z73_18740	COG0784	Response regulator, receiver
H8Z73_18740	COG5002	protein histidine kinase activity
H8Z73_18760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8Z73_18765	COG1187	pseudouridine synthase activity
H8Z73_18770	COG2813	Specifically methylates the guanine in position
H8Z73_18790	COG2202	Pas domain
H8Z73_18790	COG2205	protein histidine kinase activity
H8Z73_18810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8Z73_18815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z73_18870	COG0842	Transport permease protein
H8Z73_18875	COG1131	(ABC) transporter
H8Z73_18880	COG0025	NhaP-type Na H and K H
H8Z73_18885	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H8Z73_18890	COG1573	uracil-dna glycosylase
H8Z73_18900	COG3384	dioxygenase
H8Z73_18910	COG0583	DNA-binding transcription factor activity
H8Z73_18920	COG0667	Aldo Keto reductase
H8Z73_18930	COG3590	peptidase
H8Z73_18950	COG0531	amino acid
H8Z73_18965	COG2972	Histidine kinase
H8Z73_18980	COG3685	Protein conserved in bacteria
H8Z73_18985	COG3546	catalase activity
H8Z73_19030	COG1271	oxidase subunit
H8Z73_19035	COG1294	oxidase, subunit
H8Z73_19050	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_19055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8Z73_19075	COG1132	(ABC) transporter
H8Z73_19090	COG1063	alcohol dehydrogenase
H8Z73_19165	COG0251	oxidation-reduction process
H8Z73_19180	COG0840	transmembrane signaling receptor activity
H8Z73_19195	COG0583	DNA-binding transcription factor activity
H8Z73_19200	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8Z73_19245	COG0024	Methionine aminopeptidase
H8Z73_19280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8Z73_19285	COG1490	D-aminoacyl-tRNA deacylase activity
H8Z73_19290	COG1560	Kdo2-lipid A biosynthetic process
H8Z73_19340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8Z73_19340	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H8Z73_19345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H8Z73_19350	COG0242	peptide deformylase activity
H8Z73_19355	COG1652	LysM domain
H8Z73_19360	COG0758	DNA mediated transformation
H8Z73_19380	COG1754	DNA topoisomerase type I activity
H8Z73_19380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z73_19385	COG0009	L-threonylcarbamoyladenylate synthase
H8Z73_19400	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_19410	COG0616	signal peptide processing
H8Z73_19415	COG0534	Mate efflux family protein
H8Z73_19435	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H8Z73_19440	COG0625	glutathione transferase activity
H8Z73_19455	COG1252	NADH dehydrogenase
H8Z73_19460	COG2860	membrane
H8Z73_19465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8Z73_19470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H8Z73_19475	COG2201	protein-glutamate methylesterase activity
H8Z73_19480	COG2177	Part of the ABC transporter FtsEX involved in
H8Z73_19485	COG2884	Cell division ATP-binding protein ftsE
H8Z73_19490	COG0513	Belongs to the DEAD box helicase family
H8Z73_19495	COG3118	belongs to the thioredoxin family
H8Z73_19500	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H8Z73_19505	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H8Z73_19510	COG0583	DNA-binding transcription factor activity
H8Z73_19555	COG1518	maintenance of DNA repeat elements
H8Z73_19560	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H8Z73_19570	COG1652	LysM domain
H8Z73_19575	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8Z73_19575	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8Z73_19580	COG1473	amidohydrolase
H8Z73_19585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z73_19590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z73_19600	COG5383	Protein conserved in bacteria
H8Z73_19640	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H8Z73_19645	COG3023	N-Acetylmuramoyl-L-alanine amidase
H8Z73_19655	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z73_19665	COG0531	amino acid
H8Z73_19680	COG4682	membrane
H8Z73_19685	COG2133	pyrroloquinoline quinone binding
H8Z73_19695	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H8Z73_19700	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H8Z73_19710	COG1610	YqeY-like protein
H8Z73_19715	COG1295	ribonuclease BN
H8Z73_19720	COG0358	DNA primase activity
H8Z73_19735	COG0109	protoheme IX farnesyltransferase activity
H8Z73_19765	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H8Z73_19780	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H8Z73_19820	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H8Z73_19825	COG0739	heme binding
H8Z73_19830	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H8Z73_19840	COG2223	nitrite transmembrane transporter activity
H8Z73_19845	COG0708	Exodeoxyribonuclease III
H8Z73_19850	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8Z73_19860	COG1192	Involved in chromosome partitioning
H8Z73_19865	COG1475	DNA binding
H8Z73_19880	COG0463	Glycosyl transferase, family 2
H8Z73_19900	COG0756	dUTP diphosphatase activity
H8Z73_19905	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H8Z73_19910	COG2003	Belongs to the UPF0758 family
H8Z73_19915	COG0018	arginyl-trna synthetase
H8Z73_19930	COG4221	oxidoreductase activity
H8Z73_19935	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H8Z73_19935	COG2755	lipolytic protein G-D-S-L family
H8Z73_19945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z73_19950	COG1166	arginine decarboxylase activity
H8Z73_19955	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H8Z73_19990	COG0606	chelatase, subunit chli
H8Z73_20005	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H8Z73_20030	COG1690	Belongs to the RtcB family
H8Z73_20065	COG1090	epimerase
H8Z73_20075	COG0642	Histidine kinase
H8Z73_20100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8Z73_20125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8Z73_20130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8Z73_20145	COG0753	catalase activity
H8Z73_20160	COG2197	response regulator
H8Z73_20165	COG4585	Histidine kinase
H8Z73_20170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z73_20175	COG1136	(ABC) transporter
H8Z73_20200	COG0697	spore germination
H8Z73_20215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z73_20220	COG0180	Tryptophanyl-tRNA synthetase
H8Z73_20225	COG3237	CsbD-like
H8Z73_20265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H8Z73_20280	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H8Z73_20325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8Z73_20345	COG1199	ATP-dependent helicase activity
H8Z73_20360	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8Z73_20425	COG0625	glutathione transferase activity
H8Z73_20460	COG4555	ABC transporter
H8Z73_20470	COG1476	TRANSCRIPTIONal
H8Z73_20515	COG0543	2 iron, 2 sulfur cluster binding
H8Z73_20515	COG0633	Ferredoxin
H8Z73_20520	COG1131	(ABC) transporter
H8Z73_20525	COG0842	Transport permease protein
H8Z73_20535	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H8Z73_20570	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8Z73_20575	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8Z73_20585	COG0045	succinate-CoA ligase (ADP-forming) activity
H8Z73_20585	COG1042	CoA-binding domain protein
H8Z73_20585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8Z73_20590	COG2239	Acts as a magnesium transporter
H8Z73_20605	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8Z73_20610	COG3387	PFAM Glycoside hydrolase 15-related
H8Z73_20625	COG3100	YcgL domain-containing protein
H8Z73_20630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8Z73_20640	COG0463	Glycosyl transferase, family 2
H8Z73_20660	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_20695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z73_20710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8Z73_20735	COG0823	Involved in the tonB-independent uptake of proteins
H8Z73_20735	COG1506	peptidase
H8Z73_20735	COG4946	Tricorn protease homolog
H8Z73_20750	COG0408	coproporphyrinogen oxidase activity
H8Z73_20785	COG2815	serine threonine protein kinase
H8Z73_20785	COG0515	serine threonine protein kinase
H8Z73_20790	COG0631	protein serine/threonine phosphatase activity
H8Z73_20970	COG0210	DNA helicase
H8Z73_20980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z73_20985	COG0583	DNA-binding transcription factor activity
H8Z73_20990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H8Z73_21000	COG2159	amidohydrolase
H8Z73_21020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z73_21040	COG0357	Ribosomal RNA small subunit methyltransferase G
H8Z73_21045	COG3540	Alkaline phosphatase
H8Z73_21055	COG2091	lysine biosynthetic process via aminoadipic acid
H8Z73_21070	COG0708	Exodeoxyribonuclease III
H8Z73_21075	COG1940	carbohydrate kinase activity
H8Z73_21075	COG1846	Transcriptional regulator
H8Z73_21085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z73_21095	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8Z73_21100	COG3162	membrane
H8Z73_21110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8Z73_21135	COG3507	Belongs to the glycosyl hydrolase 43 family
H8Z73_21155	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z73_21160	COG0179	Fumarylacetoacetate (FAA) hydrolase
H8Z73_21165	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z73_21170	COG3254	rhamnose metabolic process
H8Z73_21175	COG0738	Major facilitator superfamily
H8Z73_21180	COG1414	Transcriptional regulator
H8Z73_21185	COG1971	Probably functions as a manganese efflux pump
H8Z73_21190	COG2205	protein histidine kinase activity
H8Z73_21200	COG3459	Glycosyltransferase 36 associated
H8Z73_21205	COG2211	Major facilitator Superfamily
H8Z73_21210	COG3265	gluconokinase activity
H8Z73_21215	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z73_21235	COG2911	Protein conserved in bacteria
H8Z73_21240	COG0729	surface antigen
H8Z73_21265	COG0752	glycyl-tRNA synthetase alpha subunit
H8Z73_21270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z73_21280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8Z73_21280	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z73_21290	COG0805	protein transport
H8Z73_21295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8Z73_21300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8Z73_21310	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8Z73_21330	COG2974	May be involved in recombination
H8Z73_21335	COG0037	tRNA processing
H8Z73_21340	COG2115	Belongs to the xylose isomerase family
H8Z73_21350	COG3661	Belongs to the glycosyl hydrolase 67 family
H8Z73_21360	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z73_21370	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z73_21375	COG0246	Mannitol dehydrogenase
H8Z73_21420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8Z73_21450	COG3386	PFAM SMP-30 Gluconolaconase
H8Z73_21460	COG3250	beta-galactosidase activity
H8Z73_21465	COG1904	glucuronate isomerase
H8Z73_21485	COG3693	PFAM glycoside hydrolase, family 10
H8Z73_21500	COG2211	Major facilitator Superfamily
H8Z73_21580	COG2937	Belongs to the GPAT DAPAT family
H8Z73_21610	COG0284	orotidine-5'-phosphate decarboxylase activity
H8Z73_21615	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H8Z73_21620	COG3132	Protein of unknown function, DUF480
H8Z73_21635	COG0210	DNA helicase
H8Z73_21640	COG1435	thymidine kinase activity
H8Z73_21650	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H8Z73_21660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H8Z73_21690	COG3135	benzoate transporter
H8Z73_21710	COG0676	glucose-6-phosphate 1-epimerase activity
H8Z73_21720	COG3012	SEC-C Motif Domain Protein
H8Z73_21725	COG0730	response to heat
H8Z73_21750	COG0302	gtp cyclohydrolase
H8Z73_21765	COG1566	PFAM secretion protein HlyD family protein
H8Z73_21775	COG1289	transmembrane transporter activity
H8Z73_21780	COG0477	Major facilitator Superfamily
H8Z73_21790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z73_21810	COG4691	Plasmid stability protein
H8Z73_21815	COG1487	ribonuclease activity
H8Z73_21850	COG0564	pseudouridine synthase activity
H8Z73_21905	COG1074	ATP-dependent DNA helicase activity
H8Z73_21910	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H8Z73_21925	COG1127	ABC transporter
H8Z73_21930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8Z73_21935	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8Z73_21950	COG2853	Lipoprotein
H8Z73_21960	COG0386	Belongs to the glutathione peroxidase family
H8Z73_21970	COG1322	Protein conserved in bacteria
H8Z73_21975	COG0604	alcohol dehydrogenase
H8Z73_21990	COG0625	glutathione transferase activity
H8Z73_22000	COG0531	amino acid
H8Z73_22005	COG3537	Alpha-1,2-mannosidase
H8Z73_22015	COG3706	GGDEF domain
H8Z73_22020	COG3835	regulator
H8Z73_22025	COG1929	Belongs to the glycerate kinase type-1 family
H8Z73_22030	COG2271	Major facilitator Superfamily
H8Z73_22045	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H8Z73_22050	COG0861	Integral membrane protein TerC family
H8Z73_22060	COG0584	glycerophosphoryl diester phosphodiesterase
H8Z73_22075	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H8Z73_22080	COG0726	polysaccharide deacetylase
H8Z73_22085	COG0706	membrane insertase activity
H8Z73_22090	COG0594	ribonuclease P activity
H8Z73_22105	COG2188	Transcriptional regulator
H8Z73_22125	COG2871	sodium ion transport
H8Z73_22150	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z73_22155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z73_22170	COG2217	Heavy metal translocating P-type atpase
H8Z73_22175	COG2217	Heavy metal translocating P-type atpase
H8Z73_22185	COG1063	alcohol dehydrogenase
H8Z73_22380	COG1192	Involved in chromosome partitioning
H8Z73_22550	COG3550	peptidyl-serine autophosphorylation
H8Z73_22650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8Z73_22695	COG0741	lytic transglycosylase activity
H8Z73_22790	COG1475	DNA binding
H8Z73_22830	COG0629	single-stranded DNA binding
H8Z73_22865	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8Z73_23090	COG4644	lycopene metabolic process
H8Z73_23140	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8Z73_23165	COG2132	Multicopper oxidase
H8Z73_23200	COG0010	Belongs to the arginase family
H8Z73_23205	COG2986	histidine ammonia-lyase
H8Z73_23325	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z73_23345	COG3318	Belongs to the UPF0149 family
H8Z73_23345	COG3012	SEC-C Motif Domain Protein
H8Z73_23365	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z73_23370	COG4456	Virulence-associated protein
H8Z73_23550	COG0489	protein tyrosine kinase activity
H8Z73_23585	COG4680	protein conserved in bacteria
H8Z73_23630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z73_23670	COG3012	SEC-C Motif Domain Protein
H8Z73_23670	COG3318	Belongs to the UPF0149 family
H8Z73_23690	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z73_23710	COG3451	type IV secretory pathway VirB4
H8Z73_23720	COG3838	Conjugal transfer protein Trbc
H8Z73_23725	COG4962	Type ii secretion system protein e
H8Z73_23785	COG3318	Belongs to the UPF0149 family
H8Z73_23785	COG3012	SEC-C Motif Domain Protein
H8Z73_23835	COG1192	Involved in chromosome partitioning
H8Z73_23945	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z73_23955	COG1487	ribonuclease activity
H8Z73_23970	COG3505	Type IV secretory pathway VirD4
H8Z73_24010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z73_24035	COG3318	Belongs to the UPF0149 family
H8Z73_24035	COG3012	SEC-C Motif Domain Protein