locus-tag	class	description
H8Z71_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H8Z71_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8Z71_00020	COG0187	DNA topoisomerase II activity
H8Z71_00030	COG0501	Belongs to the peptidase M48B family
H8Z71_00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H8Z71_00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z71_00115	COG0793	Belongs to the peptidase S41A family
H8Z71_00120	COG4942	peptidase
H8Z71_00130	COG2234	aminopeptidase activity
H8Z71_00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z71_00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z71_00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z71_00165	COG1064	alcohol dehydrogenase
H8Z71_00175	COG0493	'glutamate synthase
H8Z71_00180	COG0067	glutamate synthase
H8Z71_00180	COG0070	glutamate synthase
H8Z71_00180	COG0069	glutamate synthase activity
H8Z71_00230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8Z71_00245	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H8Z71_00250	COG0438	transferase activity, transferring glycosyl groups
H8Z71_00250	COG0297	glycogen (starch) synthase activity
H8Z71_00270	COG0367	asparagine synthase
H8Z71_00300	COG1132	(ABC) transporter
H8Z71_00330	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H8Z71_00415	COG1205	dead DEAH box helicase
H8Z71_00415	COG1111	helicase
H8Z71_00420	COG1272	protein, Hemolysin III
H8Z71_00440	COG0300	oxidoreductase activity
H8Z71_00445	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_00465	COG2249	NAD(P)H dehydrogenase (quinone) activity
H8Z71_00485	COG1119	ATPase activity
H8Z71_00495	COG1752	Esterase of the alpha-beta hydrolase superfamily
H8Z71_00505	COG1522	sequence-specific DNA binding
H8Z71_00510	COG3186	Phenylalanine-4-hydroxylase
H8Z71_00525	COG2755	lipolytic protein G-D-S-L family
H8Z71_00535	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_00540	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H8Z71_00545	COG1609	Transcriptional regulator
H8Z71_00550	COG3507	Belongs to the glycosyl hydrolase 43 family
H8Z71_00565	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H8Z71_00575	COG0657	acetylesterase activity
H8Z71_00575	COG2755	lipolytic protein G-D-S-L family
H8Z71_00595	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z71_00600	COG0366	Alpha amylase catalytic
H8Z71_00605	COG0366	Alpha amylase catalytic
H8Z71_00750	COG0631	protein serine/threonine phosphatase activity
H8Z71_00755	COG0515	serine threonine protein kinase
H8Z71_00755	COG2815	serine threonine protein kinase
H8Z71_00790	COG0408	coproporphyrinogen oxidase activity
H8Z71_00805	COG4946	Tricorn protease homolog
H8Z71_00805	COG1506	peptidase
H8Z71_00805	COG0823	Involved in the tonB-independent uptake of proteins
H8Z71_00830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8Z71_00845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z71_00880	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_00900	COG0463	Glycosyl transferase, family 2
H8Z71_00910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8Z71_00915	COG3100	YcgL domain-containing protein
H8Z71_00930	COG3387	PFAM Glycoside hydrolase 15-related
H8Z71_00935	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8Z71_00950	COG2239	Acts as a magnesium transporter
H8Z71_00955	COG0045	succinate-CoA ligase (ADP-forming) activity
H8Z71_00955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8Z71_00955	COG1042	CoA-binding domain protein
H8Z71_00965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8Z71_00970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8Z71_01005	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H8Z71_01015	COG0842	Transport permease protein
H8Z71_01020	COG1131	(ABC) transporter
H8Z71_01025	COG0543	2 iron, 2 sulfur cluster binding
H8Z71_01025	COG0633	Ferredoxin
H8Z71_01070	COG1476	TRANSCRIPTIONal
H8Z71_01080	COG4555	ABC transporter
H8Z71_01115	COG0625	glutathione transferase activity
H8Z71_01180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8Z71_01195	COG1199	ATP-dependent helicase activity
H8Z71_01215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8Z71_01260	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H8Z71_01275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H8Z71_01315	COG3237	CsbD-like
H8Z71_01320	COG0180	Tryptophanyl-tRNA synthetase
H8Z71_01325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z71_01340	COG0697	spore germination
H8Z71_01365	COG1136	(ABC) transporter
H8Z71_01370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z71_01375	COG4585	Histidine kinase
H8Z71_01380	COG2197	response regulator
H8Z71_01395	COG0753	catalase activity
H8Z71_01410	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8Z71_01415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8Z71_01440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8Z71_01465	COG0642	Histidine kinase
H8Z71_01475	COG1090	epimerase
H8Z71_01515	COG1690	Belongs to the RtcB family
H8Z71_01540	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H8Z71_01555	COG0606	chelatase, subunit chli
H8Z71_01590	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H8Z71_01595	COG1166	arginine decarboxylase activity
H8Z71_01600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z71_01610	COG2755	lipolytic protein G-D-S-L family
H8Z71_01610	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H8Z71_01615	COG4221	oxidoreductase activity
H8Z71_01630	COG0018	arginyl-trna synthetase
H8Z71_01635	COG2003	Belongs to the UPF0758 family
H8Z71_01640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H8Z71_01645	COG0756	dUTP diphosphatase activity
H8Z71_01665	COG0463	Glycosyl transferase, family 2
H8Z71_01680	COG1475	DNA binding
H8Z71_01685	COG1192	Involved in chromosome partitioning
H8Z71_01695	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8Z71_01700	COG0708	Exodeoxyribonuclease III
H8Z71_01705	COG2223	nitrite transmembrane transporter activity
H8Z71_01715	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H8Z71_01720	COG0739	heme binding
H8Z71_01725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H8Z71_01765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H8Z71_01780	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H8Z71_01810	COG0109	protoheme IX farnesyltransferase activity
H8Z71_01825	COG0358	DNA primase activity
H8Z71_01830	COG1295	ribonuclease BN
H8Z71_01835	COG1610	YqeY-like protein
H8Z71_01845	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H8Z71_01850	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H8Z71_01860	COG2133	pyrroloquinoline quinone binding
H8Z71_01865	COG4682	membrane
H8Z71_01880	COG0531	amino acid
H8Z71_01890	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z71_01900	COG3023	N-Acetylmuramoyl-L-alanine amidase
H8Z71_01905	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H8Z71_01945	COG5383	Protein conserved in bacteria
H8Z71_01955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z71_01960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z71_01965	COG1473	amidohydrolase
H8Z71_01970	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8Z71_01970	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8Z71_01975	COG1652	LysM domain
H8Z71_01985	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H8Z71_01990	COG1518	maintenance of DNA repeat elements
H8Z71_02035	COG0583	DNA-binding transcription factor activity
H8Z71_02040	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H8Z71_02045	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H8Z71_02050	COG3118	belongs to the thioredoxin family
H8Z71_02055	COG0513	Belongs to the DEAD box helicase family
H8Z71_02060	COG2884	Cell division ATP-binding protein ftsE
H8Z71_02065	COG2177	Part of the ABC transporter FtsEX involved in
H8Z71_02070	COG2201	protein-glutamate methylesterase activity
H8Z71_02075	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H8Z71_02080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8Z71_02085	COG2860	membrane
H8Z71_02090	COG1252	NADH dehydrogenase
H8Z71_02105	COG0625	glutathione transferase activity
H8Z71_02110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H8Z71_02130	COG0534	Mate efflux family protein
H8Z71_02135	COG0616	signal peptide processing
H8Z71_02145	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_02160	COG0009	L-threonylcarbamoyladenylate synthase
H8Z71_02165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z71_02165	COG1754	DNA topoisomerase type I activity
H8Z71_02185	COG0758	DNA mediated transformation
H8Z71_02190	COG1652	LysM domain
H8Z71_02195	COG0242	peptide deformylase activity
H8Z71_02200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H8Z71_02205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H8Z71_02205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8Z71_02255	COG1560	Kdo2-lipid A biosynthetic process
H8Z71_02260	COG1490	D-aminoacyl-tRNA deacylase activity
H8Z71_02265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8Z71_02455	COG3179	chitinase
H8Z71_02500	COG4695	Portal protein
H8Z71_02530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8Z71_02575	COG0024	Methionine aminopeptidase
H8Z71_02620	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8Z71_02625	COG0583	DNA-binding transcription factor activity
H8Z71_02640	COG0840	transmembrane signaling receptor activity
H8Z71_02655	COG0251	oxidation-reduction process
H8Z71_02730	COG1063	alcohol dehydrogenase
H8Z71_02745	COG1132	(ABC) transporter
H8Z71_02765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8Z71_02770	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_02785	COG1294	oxidase, subunit
H8Z71_02790	COG1271	oxidase subunit
H8Z71_02835	COG3546	catalase activity
H8Z71_02840	COG3685	Protein conserved in bacteria
H8Z71_02855	COG2972	Histidine kinase
H8Z71_02870	COG0531	amino acid
H8Z71_02890	COG3590	peptidase
H8Z71_02900	COG0667	Aldo Keto reductase
H8Z71_02910	COG0583	DNA-binding transcription factor activity
H8Z71_02920	COG3384	dioxygenase
H8Z71_02930	COG1573	uracil-dna glycosylase
H8Z71_02935	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H8Z71_02940	COG0025	NhaP-type Na H and K H
H8Z71_02945	COG1131	(ABC) transporter
H8Z71_02950	COG0842	Transport permease protein
H8Z71_03010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z71_03015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8Z71_03035	COG2205	protein histidine kinase activity
H8Z71_03035	COG2202	Pas domain
H8Z71_03055	COG2813	Specifically methylates the guanine in position
H8Z71_03060	COG1187	pseudouridine synthase activity
H8Z71_03065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8Z71_03085	COG5002	protein histidine kinase activity
H8Z71_03085	COG0784	Response regulator, receiver
H8Z71_03085	COG2198	Histidine kinase
H8Z71_03095	COG1666	GTP binding
H8Z71_03100	COG0697	spore germination
H8Z71_03105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H8Z71_03150	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8Z71_03160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8Z71_03180	COG0356	it plays a direct role in the translocation of protons across the membrane
H8Z71_03190	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8Z71_03195	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H8Z71_03200	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H8Z71_03205	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H8Z71_03210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H8Z71_03215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H8Z71_03230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8Z71_03235	COG4191	Histidine kinase
H8Z71_03250	COG0577	efflux transmembrane transporter activity
H8Z71_03255	COG0577	efflux transmembrane transporter activity
H8Z71_03260	COG1136	(ABC) transporter
H8Z71_03260	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8Z71_03265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z71_03270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8Z71_03325	COG0339	signal peptide processing
H8Z71_03340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z71_03345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8Z71_03360	COG2819	hydrolase of the alpha beta superfamily
H8Z71_03370	COG1956	GAF domain-containing protein
H8Z71_03375	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H8Z71_03385	COG0720	synthase
H8Z71_03390	COG4206	TonB-dependent receptor
H8Z71_03400	COG0513	Belongs to the DEAD box helicase family
H8Z71_03410	COG0625	glutathione transferase activity
H8Z71_03440	COG0626	cystathionine gamma-synthase activity
H8Z71_03455	COG0110	maltose O-acetyltransferase activity
H8Z71_03460	COG0438	transferase activity, transferring glycosyl groups
H8Z71_03460	COG1216	Glycosyl transferase, family 2
H8Z71_03465	COG3754	Rhamnan synthesis protein F
H8Z71_03475	COG2226	methyltransferase
H8Z71_03495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z71_03505	COG0300	oxidoreductase activity
H8Z71_03510	COG0277	FAD linked oxidase domain protein
H8Z71_03515	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8Z71_03515	COG0546	phosphoglycolate phosphatase activity
H8Z71_03530	COG2086	electron transfer activity
H8Z71_03560	COG0662	Cupin 2, conserved barrel domain protein
H8Z71_03560	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H8Z71_03565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8Z71_03600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8Z71_03600	COG3218	ABC-type transport auxiliary lipoprotein component
H8Z71_03605	COG1127	ABC transporter
H8Z71_03610	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8Z71_03625	COG0442	prolyl-tRNA aminoacylation
H8Z71_03635	COG1183	phosphatidylcholine synthase activity
H8Z71_03665	COG0525	valine-tRNA ligase activity
H8Z71_03680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8Z71_03690	COG0795	lipopolysaccharide-transporting ATPase activity
H8Z71_03705	COG4974	Belongs to the 'phage' integrase family
H8Z71_03710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8Z71_03715	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H8Z71_03715	COG0047	phosphoribosylformylglycinamidine synthase activity
H8Z71_03720	COG5295	Hep Hag repeat protein
H8Z71_03725	COG1404	Belongs to the peptidase S8 family
H8Z71_03730	COG5295	Hep Hag repeat protein
H8Z71_03735	COG1404	Belongs to the peptidase S8 family
H8Z71_03740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z71_03745	COG1459	type II secretion system
H8Z71_03750	COG2165	general secretion pathway protein
H8Z71_03755	COG4970	Tfp pilus assembly protein FimT
H8Z71_03760	COG2165	general secretion pathway protein
H8Z71_03765	COG4795	General secretion pathway protein
H8Z71_03770	COG3156	type II secretion system protein K
H8Z71_03775	COG3166	PFAM Fimbrial assembly family protein
H8Z71_03790	COG1450	Type ii and iii secretion system protein
H8Z71_03805	COG2188	Transcriptional regulator
H8Z71_03850	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H8Z71_03865	COG1215	transferase activity, transferring glycosyl groups
H8Z71_03870	COG1215	transferase activity, transferring glycosyl groups
H8Z71_03875	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H8Z71_03880	COG0457	Tetratricopeptide repeat
H8Z71_03900	COG0242	peptide deformylase activity
H8Z71_03905	COG1307	EDD domain protein, DegV family
H8Z71_03940	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8Z71_03945	COG0726	polysaccharide deacetylase
H8Z71_03950	COG4773	Receptor
H8Z71_03970	COG1162	GTPase activity
H8Z71_03995	COG2211	Major facilitator Superfamily
H8Z71_04000	COG1609	Transcriptional regulator
H8Z71_04005	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_04010	COG2851	Citrate transporter
H8Z71_04025	COG0642	Histidine kinase
H8Z71_04035	COG2197	response regulator
H8Z71_04050	COG0667	Aldo Keto reductase
H8Z71_04055	COG0583	DNA-binding transcription factor activity
H8Z71_04080	COG1301	dicarboxylic acid transport
H8Z71_04085	COG0280	phosphate acetyltransferase
H8Z71_04085	COG0281	malic enzyme
H8Z71_04110	COG1560	Kdo2-lipid A biosynthetic process
H8Z71_04115	COG1519	Transferase
H8Z71_04120	COG1538	Outer membrane efflux protein
H8Z71_04125	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H8Z71_04145	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H8Z71_04150	COG0066	3-isopropylmalate dehydratase activity
H8Z71_04155	COG0473	3-isopropylmalate dehydrogenase activity
H8Z71_04160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H8Z71_04180	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H8Z71_04185	COG0405	Gamma-glutamyltransferase
H8Z71_04190	COG0840	transmembrane signaling receptor activity
H8Z71_04200	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H8Z71_04205	COG3710	Transcriptional regulator
H8Z71_04225	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H8Z71_04235	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H8Z71_04250	COG0563	adenylate kinase activity
H8Z71_04255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8Z71_04265	COG3781	membrane
H8Z71_04270	COG0671	phosphoesterase, PA-phosphatase related
H8Z71_04280	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_04290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z71_04295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8Z71_04325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z71_04340	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8Z71_04355	COG0352	thiamine-phosphate diphosphorylase activity
H8Z71_04360	COG1773	rubredoxin
H8Z71_04365	COG2912	Transglutaminase-like superfamily
H8Z71_04375	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H8Z71_04385	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H8Z71_04405	COG3079	Belongs to the UPF0149 family
H8Z71_04410	COG0006	proline dipeptidase activity
H8Z71_04420	COG0006	proline dipeptidase activity
H8Z71_04435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8Z71_04440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8Z71_04450	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H8Z71_04455	COG1561	YicC-like family, N-terminal region
H8Z71_04460	COG0194	GDP metabolic process
H8Z71_04470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8Z71_04480	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8Z71_04505	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H8Z71_04535	COG0714	Associated with various cellular activities
H8Z71_04555	COG2304	oxidoreductase activity
H8Z71_04565	COG1301	dicarboxylic acid transport
H8Z71_04570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H8Z71_04575	COG0596	Alpha beta hydrolase
H8Z71_04580	COG4773	Receptor
H8Z71_04595	COG0739	heme binding
H8Z71_04600	COG1376	ErfK ybiS ycfS ynhG family protein
H8Z71_04635	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H8Z71_04640	COG4149	molybdate abc transporter
H8Z71_04645	COG0725	ABC transporter, periplasmic molybdate-binding protein
H8Z71_04650	COG3453	Protein conserved in bacteria
H8Z71_04650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z71_04660	COG3047	cAMP biosynthetic process
H8Z71_04665	COG3047	cAMP biosynthetic process
H8Z71_04675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8Z71_04695	COG0126	phosphoglycerate kinase activity
H8Z71_04705	COG0469	pyruvate kinase activity
H8Z71_04710	COG3588	fructose-bisphosphate aldolase
H8Z71_04715	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H8Z71_04730	COG1648	precorrin-2 dehydrogenase activity
H8Z71_04730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8Z71_04745	COG0784	Response regulator, receiver
H8Z71_04745	COG2205	protein histidine kinase activity
H8Z71_04745	COG2198	Histidine kinase
H8Z71_04765	COG0175	sulfate reduction
H8Z71_04770	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8Z71_04775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8Z71_04780	COG0175	sulfate reduction
H8Z71_04785	COG0529	Catalyzes the synthesis of activated sulfate
H8Z71_04785	COG2895	sulfate adenylyltransferase (ATP) activity
H8Z71_04795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z71_04830	COG0308	aminopeptidase N
H8Z71_04840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8Z71_04855	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z71_04860	COG3250	beta-galactosidase activity
H8Z71_04880	COG1970	mechanosensitive ion channel activity
H8Z71_04900	COG0471	metal ion transport
H8Z71_04900	COG3273	potassium ion transport
H8Z71_04905	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H8Z71_04910	COG2022	thiamine diphosphate biosynthetic process
H8Z71_04945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H8Z71_05065	COG4191	Histidine kinase
H8Z71_05065	COG0784	Response regulator, receiver
H8Z71_05070	COG4191	Histidine kinase
H8Z71_05070	COG0784	Response regulator, receiver
H8Z71_05095	COG2003	Belongs to the UPF0758 family
H8Z71_05120	COG3039	Transposase
H8Z71_05180	COG0745	RESPONSE REGULATOR receiver
H8Z71_05185	COG5002	protein histidine kinase activity
H8Z71_05210	COG0237	dephospho-CoA kinase activity
H8Z71_05215	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H8Z71_05245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z71_05260	COG0045	succinate-CoA ligase (ADP-forming) activity
H8Z71_05265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H8Z71_05315	COG4644	lycopene metabolic process
H8Z71_05320	COG2951	lytic endotransglycosylase activity
H8Z71_05340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8Z71_05340	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H8Z71_05350	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z71_05355	COG0564	pseudouridine synthase activity
H8Z71_05370	COG3011	Protein conserved in bacteria
H8Z71_05375	COG0840	transmembrane signaling receptor activity
H8Z71_05390	COG3387	PFAM Glycoside hydrolase 15-related
H8Z71_05395	COG1877	trehalose-phosphatase activity
H8Z71_05435	COG2827	Endonuclease containing a URI domain
H8Z71_05440	COG4771	TonB-dependent receptor
H8Z71_05445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z71_05450	COG0667	Aldo Keto reductase
H8Z71_05455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H8Z71_05460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z71_05465	COG1116	anion transmembrane transporter activity
H8Z71_05470	COG0542	response to heat
H8Z71_05475	COG4206	TonB-dependent receptor
H8Z71_05495	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8Z71_05505	COG1492	cobalamin metabolic process
H8Z71_05515	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H8Z71_05540	COG0019	diaminopimelate decarboxylase activity
H8Z71_05555	COG4264	IucA IucC family
H8Z71_05565	COG4772	TonB-dependent receptor
H8Z71_05590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8Z71_05590	COG4651	solute:proton antiporter activity
H8Z71_05620	COG0488	(ABC) transporter
H8Z71_05660	COG0477	Major facilitator Superfamily
H8Z71_05675	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H8Z71_05690	COG0217	transcriptional regulatory protein
H8Z71_05695	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H8Z71_05700	COG0632	four-way junction helicase activity
H8Z71_05705	COG3158	transport of potassium into the cell
H8Z71_05715	COG2255	four-way junction helicase activity
H8Z71_05720	COG0824	Thioesterase
H8Z71_05730	COG0848	biopolymer transport protein
H8Z71_05740	COG0823	Involved in the tonB-independent uptake of proteins
H8Z71_05745	COG2885	chlorophyll binding
H8Z71_05755	COG0602	queuosine metabolic process
H8Z71_05765	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H8Z71_05770	COG3920	Histidine kinase
H8Z71_05790	COG0840	transmembrane signaling receptor activity
H8Z71_05820	COG0514	ATP-dependent DNA helicase (RecQ)
H8Z71_05825	COG0783	Belongs to the Dps family
H8Z71_05830	COG1643	Atp-dependent helicase
H8Z71_05845	COG0837	glucose binding
H8Z71_05860	COG0535	radical SAM domain protein
H8Z71_05865	COG0535	radical SAM domain protein
H8Z71_05870	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
H8Z71_05875	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H8Z71_05885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8Z71_05895	COG1215	transferase activity, transferring glycosyl groups
H8Z71_05900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8Z71_05910	COG1199	ATP-dependent helicase activity
H8Z71_05930	COG0189	ligase activity
H8Z71_05945	COG0835	chemotaxis
H8Z71_05950	COG0840	transmembrane signaling receptor activity
H8Z71_05955	COG2198	Histidine kinase
H8Z71_05955	COG0784	Response regulator, receiver
H8Z71_05955	COG0643	Histidine kinase
H8Z71_05975	COG1446	asparaginase
H8Z71_05980	COG3142	Participates in the control of copper homeostasis
H8Z71_06015	COG3537	Alpha-1,2-mannosidase
H8Z71_06025	COG1486	melibiose metabolic process
H8Z71_06035	COG0531	amino acid
H8Z71_06050	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z71_06060	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H8Z71_06065	COG3858	chitin binding
H8Z71_06065	COG1388	LysM domain
H8Z71_06080	COG0837	glucose binding
H8Z71_06085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H8Z71_06095	COG0494	nUDIX hydrolase
H8Z71_06105	COG3956	TIGRFAM MazG family protein
H8Z71_06110	COG1742	UPF0060 membrane protein
H8Z71_06115	COG0330	HflC and HflK could
H8Z71_06125	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H8Z71_06130	COG0509	glycine decarboxylation via glycine cleavage system
H8Z71_06160	COG1960	acyl-CoA dehydrogenase activity
H8Z71_06170	COG1309	transcriptional regulator
H8Z71_06180	COG4771	TonB-dependent receptor
H8Z71_06190	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H8Z71_06195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8Z71_06200	COG0463	Glycosyl transferase, family 2
H8Z71_06205	COG0517	IMP dehydrogenase activity
H8Z71_06205	COG0516	GMP reductase activity
H8Z71_06210	COG2982	Protein involved in outer membrane biogenesis
H8Z71_06215	COG1272	protein, Hemolysin III
H8Z71_06220	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H8Z71_06225	COG0739	heme binding
H8Z71_06230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z71_06235	COG0626	cystathionine gamma-synthase activity
H8Z71_06240	COG0527	aspartate kinase activity
H8Z71_06240	COG0460	homoserine dehydrogenase
H8Z71_06250	COG1760	l-serine dehydratase
H8Z71_06270	COG2353	YceI-like domain
H8Z71_06275	COG0784	Response regulator, receiver
H8Z71_06275	COG2198	Histidine kinase
H8Z71_06275	COG2205	protein histidine kinase activity
H8Z71_06295	COG0477	Major facilitator Superfamily
H8Z71_06380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H8Z71_06390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H8Z71_06395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H8Z71_06400	COG0259	pyridoxamine-phosphate oxidase activity
H8Z71_06410	COG1842	Phage shock protein A
H8Z71_06435	COG0754	glutathionylspermidine amidase activity
H8Z71_06445	COG2814	Major facilitator Superfamily
H8Z71_06480	COG1234	tRNA 3'-trailer cleavage
H8Z71_06500	COG0531	amino acid
H8Z71_06510	COG2197	response regulator
H8Z71_06530	COG1113	amino acid transport
H8Z71_06540	COG1271	oxidase subunit
H8Z71_06545	COG1294	oxidase, subunit
H8Z71_06560	COG2239	Acts as a magnesium transporter
H8Z71_06565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8Z71_06570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z71_06580	COG1660	Displays ATPase and GTPase activities
H8Z71_06585	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H8Z71_06590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z71_06605	COG1137	ATPase activity
H8Z71_06610	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H8Z71_06620	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H8Z71_06630	COG0271	Belongs to the BolA IbaG family
H8Z71_06635	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H8Z71_06655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H8Z71_06665	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H8Z71_06675	COG0628	permease
H8Z71_06685	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H8Z71_06690	COG3178	'Phosphotransferase
H8Z71_06700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z71_06705	COG1555	photosystem II stabilization
H8Z71_06720	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8Z71_06725	COG1477	protein flavinylation
H8Z71_06750	COG3128	pkhd-type hydroxylase
H8Z71_06755	COG4774	siderophore transport
H8Z71_06760	COG2146	nitrite reductase [NAD(P)H] activity
H8Z71_06770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H8Z71_06775	COG0719	Fe-S assembly protein
H8Z71_06780	COG0396	ATPase activity
H8Z71_06785	COG0719	Fe-S assembly protein
H8Z71_06790	COG1959	2 iron, 2 sulfur cluster binding
H8Z71_06800	COG0693	protein deglycase activity
H8Z71_06820	COG0739	heme binding
H8Z71_06835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H8Z71_06850	COG5297	Belongs to the glycosyl hydrolase family 6
H8Z71_06865	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z71_06870	COG1678	Uncharacterized ACR, COG1678
H8Z71_06875	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H8Z71_06880	COG0540	Belongs to the ATCase OTCase family
H8Z71_06885	COG1764	response to oxidative stress
H8Z71_06895	COG0384	phenazine biosynthesis protein PhzF
H8Z71_06900	COG0384	phenazine biosynthesis protein PhzF
H8Z71_06905	COG0527	aspartate kinase activity
H8Z71_06920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H8Z71_06930	COG0142	geranyltranstransferase activity
H8Z71_06935	COG0629	single-stranded DNA binding
H8Z71_06940	COG5001	Diguanylate cyclase
H8Z71_06940	COG4251	negative regulation of phosphorylation
H8Z71_06940	COG3706	GGDEF domain
H8Z71_06940	COG2203	Gaf domain
H8Z71_06960	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8Z71_06965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H8Z71_06970	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H8Z71_07005	COG2879	small protein
H8Z71_07010	COG1966	Carbon starvation protein
H8Z71_07015	COG1741	Belongs to the pirin family
H8Z71_07030	COG1741	Belongs to the pirin family
H8Z71_07040	COG1515	deoxyribonuclease V activity
H8Z71_07045	COG0588	phosphoglycerate mutase activity
H8Z71_07055	COG3590	peptidase
H8Z71_07060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z71_07065	COG2201	protein-glutamate methylesterase activity
H8Z71_07070	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8Z71_07075	COG2202	Pas domain
H8Z71_07075	COG2200	EAL domain
H8Z71_07075	COG2199	diguanylate cyclase activity
H8Z71_07080	COG0835	chemotaxis
H8Z71_07085	COG0840	transmembrane signaling receptor activity
H8Z71_07090	COG0643	Histidine kinase
H8Z71_07090	COG2198	Histidine kinase
H8Z71_07120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H8Z71_07130	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H8Z71_07135	COG0745	RESPONSE REGULATOR receiver
H8Z71_07140	COG2205	protein histidine kinase activity
H8Z71_07155	COG4452	Inner membrane protein CreD
H8Z71_07180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z71_07185	COG0735	belongs to the Fur family
H8Z71_07200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z71_07210	COG1309	transcriptional regulator
H8Z71_07220	COG2207	Transcriptional regulator
H8Z71_07230	COG0583	DNA-binding transcription factor activity
H8Z71_07235	COG2814	Major facilitator Superfamily
H8Z71_07240	COG0667	Aldo Keto reductase
H8Z71_07360	COG5001	Diguanylate cyclase
H8Z71_07360	COG5002	protein histidine kinase activity
H8Z71_07365	COG1187	pseudouridine synthase activity
H8Z71_07385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H8Z71_07395	COG0475	glutathione-regulated potassium exporter activity
H8Z71_07400	COG5002	protein histidine kinase activity
H8Z71_07400	COG5000	phosphorelay sensor kinase activity
H8Z71_07405	COG0745	RESPONSE REGULATOR receiver
H8Z71_07410	COG1538	Outer membrane efflux protein
H8Z71_07440	COG1132	(ABC) transporter
H8Z71_07495	COG2155	Conserved Protein
H8Z71_07520	COG3118	belongs to the thioredoxin family
H8Z71_07530	COG0495	leucyl-tRNA aminoacylation
H8Z71_07545	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H8Z71_07560	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H8Z71_07575	COG2968	Membrane
H8Z71_07580	COG0424	maF-like protein
H8Z71_07590	COG3164	Protein of unknown function
H8Z71_07600	COG0312	modulator of DNA gyrase
H8Z71_07605	COG3028	Belongs to the UPF0307 family
H8Z71_07610	COG0312	modulator of DNA gyrase
H8Z71_07620	COG4104	PAAR repeat-containing protein
H8Z71_07625	COG0142	geranyltranstransferase activity
H8Z71_07630	COG1722	exodeoxyribonuclease VII activity
H8Z71_07635	COG0037	tRNA processing
H8Z71_07640	COG1785	Belongs to the alkaline phosphatase family
H8Z71_07645	COG1301	dicarboxylic acid transport
H8Z71_07650	COG4106	trans-aconitate 2-methyltransferase activity
H8Z71_07660	COG0791	NLP P60 protein
H8Z71_07665	COG0791	NLP P60 protein
H8Z71_07670	COG1047	Peptidyl-prolyl cis-trans
H8Z71_07675	COG2311	Membrane
H8Z71_07680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z71_07685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8Z71_07705	COG3590	peptidase
H8Z71_07710	COG3590	peptidase
H8Z71_07730	COG0489	protein tyrosine kinase activity
H8Z71_07735	COG0717	Belongs to the dCTP deaminase family
H8Z71_07765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z71_07780	COG0494	nUDIX hydrolase
H8Z71_07785	COG0433	COG0433 Predicted ATPase
H8Z71_07795	COG0688	phosphatidylethanolamine metabolic process
H8Z71_07805	COG2890	protein-(glutamine-N5) methyltransferase activity
H8Z71_07810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H8Z71_07815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8Z71_07820	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H8Z71_07840	COG0101	tRNA pseudouridine synthase activity
H8Z71_07845	COG0135	phosphoribosylanthranilate isomerase activity
H8Z71_07855	COG0133	tryptophan synthase activity
H8Z71_07865	COG0159	tryptophan synthase activity
H8Z71_07870	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H8Z71_07875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8Z71_07905	COG0300	oxidoreductase activity
H8Z71_07910	COG0149	triose-phosphate isomerase activity
H8Z71_07925	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z71_07930	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z71_07935	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z71_07940	COG0649	NAD binding
H8Z71_07945	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H8Z71_07950	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H8Z71_07960	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H8Z71_07965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z71_07990	COG1007	ATP synthesis coupled electron transport
H8Z71_08000	COG0779	Required for maturation of 30S ribosomal subunits
H8Z71_08005	COG0195	Participates in both transcription termination and antitermination
H8Z71_08010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H8Z71_08015	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H8Z71_08020	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H8Z71_08025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H8Z71_08030	COG1185	polyribonucleotide nucleotidyltransferase activity
H8Z71_08065	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8Z71_08075	COG2095	MarC family integral membrane protein
H8Z71_08085	COG1611	Belongs to the LOG family
H8Z71_08090	COG3275	phosphorelay sensor kinase activity
H8Z71_08180	COG3179	chitinase
H8Z71_08225	COG4695	Portal protein
H8Z71_08315	COG0556	nucleotide-excision repair
H8Z71_08330	COG3505	Type IV secretory pathway VirD4
H8Z71_08350	COG2948	multi-organism process
H8Z71_08370	COG3702	type iv secretory pathway
H8Z71_08425	COG0366	Alpha amylase catalytic
H8Z71_08440	COG1082	Xylose isomerase domain protein TIM barrel
H8Z71_08465	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H8Z71_08470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H8Z71_08485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H8Z71_08490	COG0072	phenylalanine-tRNA ligase activity
H8Z71_08490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z71_08540	COG0438	transferase activity, transferring glycosyl groups
H8Z71_08545	COG0438	transferase activity, transferring glycosyl groups
H8Z71_08555	COG0438	transferase activity, transferring glycosyl groups
H8Z71_08580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z71_08585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z71_08590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z71_08610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H8Z71_08620	COG1960	acyl-CoA dehydrogenase activity
H8Z71_08635	COG3040	lipid binding
H8Z71_08650	COG0322	excinuclease ABC activity
H8Z71_08665	COG4191	Histidine kinase
H8Z71_08665	COG0784	Response regulator, receiver
H8Z71_08670	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H8Z71_08675	COG1194	a g-specific adenine glycosylase
H8Z71_08680	COG0552	protein localization to endoplasmic reticulum
H8Z71_08690	COG3938	Belongs to the proline racemase family
H8Z71_08695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z71_08710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8Z71_08720	COG0006	proline dipeptidase activity
H8Z71_08735	COG0531	amino acid
H8Z71_08815	COG0326	Molecular chaperone. Has ATPase activity
H8Z71_08820	COG0742	ribosomal rna small subunit methyltransferase
H8Z71_08825	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H8Z71_08835	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8Z71_08840	COG0405	Gamma-glutamyltransferase
H8Z71_08845	COG3291	Pkd domain containing protein
H8Z71_08850	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H8Z71_08885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H8Z71_08890	COG0343	queuine tRNA-ribosyltransferase activity
H8Z71_08895	COG1862	Preprotein translocase
H8Z71_08905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8Z71_08950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8Z71_08950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8Z71_08955	COG1105	Belongs to the carbohydrate kinase PfkB family
H8Z71_08960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8Z71_08960	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z71_08965	COG1609	Transcriptional regulator
H8Z71_08970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z71_08975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z71_08985	COG2902	Dehydrogenase
H8Z71_08995	COG0477	Major facilitator Superfamily
H8Z71_09005	COG2205	protein histidine kinase activity
H8Z71_09005	COG0784	Response regulator, receiver
H8Z71_09005	COG5002	protein histidine kinase activity
H8Z71_09010	COG2733	membrane
H8Z71_09020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H8Z71_09025	COG2223	nitrite transmembrane transporter activity
H8Z71_09030	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H8Z71_09035	COG0243	molybdopterin cofactor binding
H8Z71_09045	COG0477	Major facilitator Superfamily
H8Z71_09050	COG2703	oxygen carrier activity
H8Z71_09060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z71_09065	COG0174	glutamine synthetase
H8Z71_09070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H8Z71_09085	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H8Z71_09105	COG3842	ATPase activity
H8Z71_09110	COG1176	ABC-type spermidine putrescine transport system, permease component I
H8Z71_09115	COG1177	transmembrane transport
H8Z71_09120	COG1012	belongs to the aldehyde dehydrogenase family
H8Z71_09135	COG4535	Mg2 and Co2 transporter CorC
H8Z71_09145	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H8Z71_09155	COG1702	phosphate starvation-inducible protein PhoH
H8Z71_09160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8Z71_09175	COG0741	lytic transglycosylase activity
H8Z71_09180	COG0723	plastoquinol--plastocyanin reductase activity
H8Z71_09185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8Z71_09190	COG2857	Cytochrome c1
H8Z71_09195	COG0625	glutathione transferase activity
H8Z71_09200	COG2969	positive regulation of protein catabolic process
H8Z71_09220	COG1201	RNA secondary structure unwinding
H8Z71_09225	COG2094	Belongs to the DNA glycosylase MPG family
H8Z71_09230	COG0840	transmembrane signaling receptor activity
H8Z71_09235	COG0835	chemotaxis
H8Z71_09315	COG1073	alpha beta
H8Z71_09315	COG2226	methyltransferase
H8Z71_09325	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_09340	COG1238	metal cluster binding
H8Z71_09375	COG3279	Response regulator of the LytR AlgR family
H8Z71_09415	COG4566	intracellular signal transduction
H8Z71_09425	COG5001	Diguanylate cyclase
H8Z71_09445	COG3685	Protein conserved in bacteria
H8Z71_09470	COG1648	precorrin-2 dehydrogenase activity
H8Z71_09470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8Z71_09485	COG2814	Major facilitator Superfamily
H8Z71_09500	COG1335	isochorismatase
H8Z71_09520	COG2197	response regulator
H8Z71_09540	COG0583	DNA-binding transcription factor activity
H8Z71_09545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8Z71_09550	COG3002	Belongs to the UPF0753 family
H8Z71_09565	COG1396	sequence-specific DNA binding
H8Z71_09570	COG5489	Protein of unknown function (DUF736)
H8Z71_09580	COG2003	Belongs to the UPF0758 family
H8Z71_09610	COG0582	viral genome integration into host DNA
H8Z71_09615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8Z71_09615	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z71_09625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H8Z71_09635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8Z71_09635	COG0475	glutathione-regulated potassium exporter activity
H8Z71_09640	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H8Z71_09650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8Z71_09655	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H8Z71_09665	COG0776	regulation of translation
H8Z71_09670	COG0539	negative regulation of cytoplasmic translation
H8Z71_09675	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H8Z71_09690	COG2957	Belongs to the agmatine deiminase family
H8Z71_09695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8Z71_09720	COG0395	ABC-type sugar transport system, permease component
H8Z71_09725	COG1175	transmembrane transport
H8Z71_09755	COG2350	Protein conserved in bacteria
H8Z71_09760	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H8Z71_09765	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H8Z71_09770	COG1187	pseudouridine synthase activity
H8Z71_09790	COG0436	Aminotransferase
H8Z71_09795	COG4133	protoheme IX ABC transporter activity
H8Z71_09815	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H8Z71_09820	COG1138	Cytochrome C-type biogenesis protein
H8Z71_09840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z71_09845	COG1278	Cold shock
H8Z71_09850	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H8Z71_09855	COG4988	ABC transporter
H8Z71_09900	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H8Z71_09905	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H8Z71_09915	COG0165	Argininosuccinate lyase
H8Z71_09920	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H8Z71_09930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H8Z71_09935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z71_09945	COG0137	argininosuccinate synthase activity
H8Z71_09950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H8Z71_09960	COG0215	cysteine-tRNA ligase activity
H8Z71_09965	COG2166	iron-sulfur cluster assembly
H8Z71_09980	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H8Z71_09985	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H8Z71_10015	COG4302	ethanolamine ammonia-lyase activity
H8Z71_10070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8Z71_10075	COG0402	S-adenosylhomocysteine deaminase activity
H8Z71_10085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8Z71_10090	COG1509	lysine 2,3-aminomutase activity
H8Z71_10095	COG3300	MHYT domain
H8Z71_10095	COG5001	Diguanylate cyclase
H8Z71_10110	COG0483	inositol monophosphate 1-phosphatase activity
H8Z71_10115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8Z71_10130	COG0488	(ABC) transporter
H8Z71_10135	COG0513	Belongs to the DEAD box helicase family
H8Z71_10140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8Z71_10145	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H8Z71_10160	COG0625	glutathione transferase activity
H8Z71_10170	COG4681	YaeQ
H8Z71_10175	COG2081	HI0933 family
H8Z71_10185	COG0501	Belongs to the peptidase M48B family
H8Z71_10190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z71_10195	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_10220	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H8Z71_10225	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8Z71_10230	COG0802	atpase or kinase
H8Z71_10235	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H8Z71_10235	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8Z71_10240	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8Z71_10245	COG1570	exodeoxyribonuclease VII activity
H8Z71_10255	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8Z71_10410	COG0316	Belongs to the HesB IscA family
H8Z71_10410	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H8Z71_10415	COG2154	pterin-4-alpha-carbinolamine dehydratase
H8Z71_10425	COG0428	transporter
H8Z71_10430	COG3064	Membrane
H8Z71_10440	COG1530	ribonuclease E activity
H8Z71_10450	COG1054	Belongs to the UPF0176 family
H8Z71_10470	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H8Z71_10480	COG0582	viral genome integration into host DNA
H8Z71_10495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z71_10500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z71_10585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8Z71_10650	COG0629	single-stranded DNA binding
H8Z71_10655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z71_10660	COG0270	DNA (cytosine-5-)-methyltransferase activity
H8Z71_10835	COG2003	Belongs to the UPF0758 family
H8Z71_10940	COG0583	DNA-binding transcription factor activity
H8Z71_10945	COG1396	sequence-specific DNA binding
H8Z71_10955	COG0582	viral genome integration into host DNA
H8Z71_10965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8Z71_10970	COG0322	excinuclease ABC activity
H8Z71_10980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8Z71_10985	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H8Z71_10990	COG1663	tetraacyldisaccharide 4'-kinase activity
H8Z71_10995	COG1132	(ABC) transporter
H8Z71_11005	COG0811	peptide transport
H8Z71_11020	COG1136	(ABC) transporter
H8Z71_11025	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8Z71_11035	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H8Z71_11040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H8Z71_11055	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H8Z71_11080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8Z71_11085	COG0837	glucose binding
H8Z71_11090	COG0363	glucosamine-6-phosphate deaminase activity
H8Z71_11095	COG0129	dihydroxy-acid dehydratase activity
H8Z71_11100	COG0800	Aldolase
H8Z71_11175	COG0784	Response regulator, receiver
H8Z71_11175	COG2205	protein histidine kinase activity
H8Z71_11180	COG2183	response to ionizing radiation
H8Z71_11190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z71_11190	COG0723	plastoquinol--plastocyanin reductase activity
H8Z71_11205	COG3243	poly(R)-hydroxyalkanoic acid synthase
H8Z71_11215	COG1183	phosphatidylcholine synthase activity
H8Z71_11220	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_11235	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H8Z71_11245	COG0668	transmembrane transport
H8Z71_11250	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H8Z71_11265	COG1914	H( )-stimulated, divalent metal cation uptake system
H8Z71_11280	COG0746	molybdenum cofactor guanylyltransferase activity
H8Z71_11285	COG0303	'Molybdopterin
H8Z71_11295	COG0708	Exodeoxyribonuclease III
H8Z71_11330	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H8Z71_11335	COG0303	'Molybdopterin
H8Z71_11340	COG1160	GTP binding
H8Z71_11345	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z71_11355	COG1426	Protein conserved in bacteria
H8Z71_11365	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H8Z71_11380	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8Z71_11380	COG1024	Enoyl-CoA hydratase
H8Z71_11385	COG0183	Belongs to the thiolase family
H8Z71_11390	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8Z71_11395	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H8Z71_11405	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H8Z71_11415	COG1674	ftsk spoiiie
H8Z71_11420	COG0492	ferredoxin-NADP+ reductase activity
H8Z71_11430	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H8Z71_11440	COG0542	response to heat
H8Z71_11455	COG0482	sulfurtransferase activity
H8Z71_11460	COG2915	High frequency lysogenization protein hflD homolog
H8Z71_11490	COG5002	protein histidine kinase activity
H8Z71_11510	COG0835	chemotaxis
H8Z71_11510	COG0784	Response regulator, receiver
H8Z71_11520	COG1558	bacterial-type flagellum-dependent cell motility
H8Z71_11525	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H8Z71_11535	COG4787	bacterial-type flagellum-dependent cell motility
H8Z71_11545	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H8Z71_11550	COG1706	bacterial-type flagellum-dependent cell motility
H8Z71_11555	COG1705	Flagellar rod assembly protein muramidase FlgJ
H8Z71_11555	COG3951	Flagellar rod assembly protein muramidase FlgJ
H8Z71_11565	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8Z71_11570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8Z71_11580	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H8Z71_11610	COG2201	protein-glutamate methylesterase activity
H8Z71_11630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z71_11635	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_11640	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_11670	COG1677	Flagellar hook-basal body complex protein FliE
H8Z71_11720	COG3190	flagellar
H8Z71_11735	COG1684	flagellar biosynthetic protein fliR
H8Z71_11760	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8Z71_11790	COG2198	Histidine kinase
H8Z71_11790	COG0784	Response regulator, receiver
H8Z71_11790	COG0643	Histidine kinase
H8Z71_11800	COG0641	radical SAM
H8Z71_11885	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H8Z71_11890	COG1360	Flagellar Motor Protein
H8Z71_11900	COG0835	chemotaxis
H8Z71_11910	COG0745	RESPONSE REGULATOR receiver
H8Z71_11915	COG0643	Histidine kinase
H8Z71_11915	COG2198	Histidine kinase
H8Z71_11920	COG0840	transmembrane signaling receptor activity
H8Z71_11935	COG0840	transmembrane signaling receptor activity
H8Z71_11945	COG0840	transmembrane signaling receptor activity
H8Z71_11950	COG0840	transmembrane signaling receptor activity
H8Z71_11955	COG0840	transmembrane signaling receptor activity
H8Z71_11960	COG0840	transmembrane signaling receptor activity
H8Z71_11965	COG0840	transmembrane signaling receptor activity
H8Z71_11970	COG0840	transmembrane signaling receptor activity
H8Z71_11975	COG0840	transmembrane signaling receptor activity
H8Z71_11980	COG0840	transmembrane signaling receptor activity
H8Z71_11985	COG0840	transmembrane signaling receptor activity
H8Z71_11995	COG0835	chemotaxis
H8Z71_12005	COG0840	transmembrane signaling receptor activity
H8Z71_12015	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H8Z71_12020	COG2201	protein-glutamate methylesterase activity
H8Z71_12030	COG2267	carboxylic ester hydrolase activity
H8Z71_12065	COG1024	Enoyl-CoA hydratase
H8Z71_12070	COG2205	protein histidine kinase activity
H8Z71_12070	COG2198	Histidine kinase
H8Z71_12070	COG0784	Response regulator, receiver
H8Z71_12080	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8Z71_12090	COG3279	Response regulator of the LytR AlgR family
H8Z71_12130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H8Z71_12140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z71_12145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H8Z71_12155	COG0505	Belongs to the CarA family
H8Z71_12160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H8Z71_12165	COG2258	MOSC domain
H8Z71_12170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8Z71_12215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8Z71_12235	COG0277	FAD linked oxidase domain protein
H8Z71_12240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8Z71_12250	COG0531	amino acid
H8Z71_12255	COG0531	amino acid
H8Z71_12260	COG0235	Class ii aldolase
H8Z71_12265	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H8Z71_12270	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H8Z71_12285	COG0140	phosphoribosyl-ATP diphosphatase activity
H8Z71_12285	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H8Z71_12290	COG0107	imidazoleglycerol-phosphate synthase activity
H8Z71_12295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H8Z71_12300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H8Z71_12305	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H8Z71_12305	COG0131	Imidazoleglycerol-phosphate dehydratase
H8Z71_12310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z71_12315	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H8Z71_12320	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H8Z71_12330	COG0124	histidyl-tRNA synthetase
H8Z71_12335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z71_12385	COG3210	domain, Protein
H8Z71_12395	COG3210	domain, Protein
H8Z71_12410	COG0726	polysaccharide deacetylase
H8Z71_12410	COG1649	PFAM Uncharacterised BCR, COG1649
H8Z71_12415	COG1215	transferase activity, transferring glycosyl groups
H8Z71_12430	COG1012	belongs to the aldehyde dehydrogenase family
H8Z71_12445	COG0167	dihydroorotate dehydrogenase activity
H8Z71_12450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H8Z71_12455	COG0697	spore germination
H8Z71_12460	COG1794	racemase activity, acting on amino acids and derivatives
H8Z71_12475	COG0671	phosphoesterase, PA-phosphatase related
H8Z71_12480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H8Z71_12490	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H8Z71_12495	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z71_12505	COG4251	negative regulation of phosphorylation
H8Z71_12505	COG3706	GGDEF domain
H8Z71_12505	COG5001	Diguanylate cyclase
H8Z71_12505	COG2203	Gaf domain
H8Z71_12515	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z71_12535	COG0166	Belongs to the GPI family
H8Z71_12540	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H8Z71_12545	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H8Z71_12550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H8Z71_12570	COG1469	GTP cyclohydrolase I activity
H8Z71_12575	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8Z71_12595	COG0477	Major facilitator Superfamily
H8Z71_12600	COG2115	Belongs to the xylose isomerase family
H8Z71_12605	COG1070	Carbohydrate kinase
H8Z71_12615	COG1501	Belongs to the glycosyl hydrolase 31 family
H8Z71_12650	COG0800	Aldolase
H8Z71_12655	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z71_12665	COG3734	2-keto-3-deoxy-galactonokinase
H8Z71_12670	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H8Z71_12680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8Z71_12695	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8Z71_12700	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H8Z71_12715	COG0351	phosphomethylpyrimidine kinase
H8Z71_12715	COG0352	thiamine-phosphate diphosphorylase activity
H8Z71_12740	COG0583	DNA-binding transcription factor activity
H8Z71_12745	COG1741	Belongs to the pirin family
H8Z71_12760	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H8Z71_12765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H8Z71_12770	COG2137	regulation of response to DNA damage stimulus
H8Z71_12775	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H8Z71_12780	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8Z71_12790	COG1546	Belongs to the CinA family
H8Z71_12795	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H8Z71_12805	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8Z71_12810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8Z71_12820	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H8Z71_12825	COG1534	Rna-binding protein
H8Z71_12840	COG1238	metal cluster binding
H8Z71_12845	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H8Z71_12850	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H8Z71_12855	COG2840	Smr protein MutS2
H8Z71_12860	COG0585	pseudouridine synthase activity
H8Z71_12865	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H8Z71_12870	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H8Z71_12875	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H8Z71_12880	COG0148	phosphopyruvate hydratase activity
H8Z71_12890	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H8Z71_12895	COG0504	CTP synthase activity
H8Z71_12920	COG0306	phosphate transporter
H8Z71_12930	COG1253	flavin adenine dinucleotide binding
H8Z71_12945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z71_12950	COG0477	Major facilitator Superfamily
H8Z71_12960	COG1136	(ABC) transporter
H8Z71_12975	COG0438	transferase activity, transferring glycosyl groups
H8Z71_12985	COG2264	protein methyltransferase activity
H8Z71_13015	COG2244	polysaccharide biosynthetic process
H8Z71_13065	COG1595	DNA-templated transcription, initiation
H8Z71_13080	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8Z71_13090	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H8Z71_13100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z71_13115	COG4191	Histidine kinase
H8Z71_13115	COG0784	Response regulator, receiver
H8Z71_13120	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H8Z71_13145	COG0840	transmembrane signaling receptor activity
H8Z71_13210	COG0583	DNA-binding transcription factor activity
H8Z71_13215	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8Z71_13220	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H8Z71_13235	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H8Z71_13240	COG0077	Prephenate dehydratase
H8Z71_13240	COG1605	Chorismate mutase
H8Z71_13245	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H8Z71_13250	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H8Z71_13255	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H8Z71_13300	COG1228	amidohydrolase
H8Z71_13305	COG2986	histidine ammonia-lyase
H8Z71_13315	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H8Z71_13325	COG4993	Dehydrogenase
H8Z71_13335	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H8Z71_13350	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H8Z71_13355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8Z71_13360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z71_13370	COG3115	cell septum assembly
H8Z71_13380	COG0359	binds to the 23S rRNA
H8Z71_13385	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H8Z71_13390	COG0360	Binds together with S18 to 16S ribosomal RNA
H8Z71_13395	COG0316	Belongs to the HesB IscA family
H8Z71_13400	COG0017	Asparaginyl-tRNA synthetase
H8Z71_13420	COG2808	Putative FMN-binding domain
H8Z71_13485	COG0288	reversible hydration of carbon dioxide
H8Z71_13490	COG0662	Cupin 2, conserved barrel domain protein
H8Z71_13500	COG3844	kynureninase activity
H8Z71_13505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z71_13515	COG2925	Exonuclease
H8Z71_13540	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8Z71_13545	COG0116	Belongs to the methyltransferase superfamily
H8Z71_13545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H8Z71_13555	COG0488	(ABC) transporter
H8Z71_13590	COG0494	nUDIX hydrolase
H8Z71_13600	COG1024	Enoyl-CoA hydratase
H8Z71_13610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H8Z71_13615	COG0659	secondary active sulfate transmembrane transporter activity
H8Z71_13640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8Z71_13645	COG0573	inorganic phosphate transmembrane transporter activity
H8Z71_13650	COG0581	inorganic phosphate transmembrane transporter activity
H8Z71_13655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8Z71_13660	COG0704	Plays a role in the regulation of phosphate uptake
H8Z71_13670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8Z71_13680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8Z71_13690	COG0557	exoribonuclease II activity
H8Z71_13705	COG1960	acyl-CoA dehydrogenase activity
H8Z71_13710	COG1960	acyl-CoA dehydrogenase activity
H8Z71_13715	COG1960	acyl-CoA dehydrogenase activity
H8Z71_13720	COG1960	acyl-CoA dehydrogenase activity
H8Z71_13725	COG2226	methyltransferase
H8Z71_13730	COG1410	methionine synthase
H8Z71_13730	COG0646	methionine synthase
H8Z71_13735	COG1410	methionine synthase
H8Z71_13735	COG0646	methionine synthase
H8Z71_13745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z71_13770	COG2900	Belongs to the SlyX family
H8Z71_13785	COG0386	Belongs to the glutathione peroxidase family
H8Z71_13795	COG1725	Transcriptional regulator
H8Z71_13800	COG1131	(ABC) transporter
H8Z71_13830	COG1253	flavin adenine dinucleotide binding
H8Z71_13850	COG2850	peptidyl-arginine hydroxylation
H8Z71_13885	COG1132	(ABC) transporter
H8Z71_13890	COG0583	DNA-binding transcription factor activity
H8Z71_13920	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H8Z71_13930	COG0484	heat shock protein binding
H8Z71_13935	COG0443	Heat shock 70 kDa protein
H8Z71_13940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H8Z71_13945	COG1420	regulation of RNA biosynthetic process
H8Z71_13950	COG0497	DNA recombination
H8Z71_13960	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z71_13975	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H8Z71_14000	COG3706	GGDEF domain
H8Z71_14045	COG0583	DNA-binding transcription factor activity
H8Z71_14055	COG0415	Belongs to the DNA photolyase family
H8Z71_14060	COG0305	Participates in initiation and elongation during chromosome replication
H8Z71_14070	COG0367	asparagine synthase
H8Z71_14085	COG1960	acyl-CoA dehydrogenase activity
H8Z71_14100	COG0084	hydrolase, TatD family'
H8Z71_14105	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H8Z71_14160	COG0386	Belongs to the glutathione peroxidase family
H8Z71_14165	COG0339	signal peptide processing
H8Z71_14215	COG2814	Major facilitator Superfamily
H8Z71_14220	COG1566	PFAM secretion protein HlyD family protein
H8Z71_14250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8Z71_14265	COG4774	siderophore transport
H8Z71_14275	COG0367	asparagine synthase
H8Z71_14280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z71_14285	COG1393	Belongs to the ArsC family
H8Z71_14295	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H8Z71_14335	COG0052	Belongs to the universal ribosomal protein uS2 family
H8Z71_14340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H8Z71_14350	COG0528	UMP kinase activity
H8Z71_14355	COG0233	cytoplasmic translational termination
H8Z71_14360	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H8Z71_14365	COG0575	Belongs to the CDS family
H8Z71_14370	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H8Z71_14375	COG0750	zinc metalloprotease
H8Z71_14390	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z71_14395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z71_14400	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z71_14405	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z71_14410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H8Z71_14420	COG0825	malonyl-CoA metabolic process
H8Z71_14435	COG1981	membrane
H8Z71_14455	COG1695	Transcriptional regulator
H8Z71_14475	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8Z71_14485	COG2040	homocysteine
H8Z71_14490	COG0833	amino acid
H8Z71_14495	COG0346	lactoylglutathione lyase activity
H8Z71_14500	COG1131	(ABC) transporter
H8Z71_14515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z71_14515	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z71_14525	COG2878	Part of a membrane complex involved in electron transport
H8Z71_14540	COG1595	DNA-templated transcription, initiation
H8Z71_14565	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H8Z71_14580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H8Z71_14585	COG0251	oxidation-reduction process
H8Z71_14595	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H8Z71_14595	COG0392	lysyltransferase activity
H8Z71_14630	COG2814	Major facilitator Superfamily
H8Z71_14635	COG1902	pentaerythritol trinitrate reductase activity
H8Z71_14640	COG2824	Alkylphosphonate utilization operon protein PhnA
H8Z71_14650	COG1047	Peptidyl-prolyl cis-trans
H8Z71_14655	COG1077	Cell shape determining protein MreB Mrl
H8Z71_14670	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H8Z71_14680	COG5487	UPF0391 membrane protein
H8Z71_14685	COG1451	nucleotide metabolic process
H8Z71_14710	COG0183	Belongs to the thiolase family
H8Z71_14740	COG1793	dna ligase
H8Z71_14740	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8Z71_14750	COG1793	dna ligase
H8Z71_14755	COG1201	RNA secondary structure unwinding
H8Z71_14765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z71_14770	COG1278	Cold shock
H8Z71_14775	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H8Z71_14780	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H8Z71_14785	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z71_14790	COG3046	protein related to deoxyribodipyrimidine photolyase
H8Z71_14795	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
H8Z71_14800	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H8Z71_14805	COG2954	triphosphatase activity
H8Z71_14810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8Z71_14820	COG1381	Involved in DNA repair and RecF pathway recombination
H8Z71_14825	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H8Z71_14830	COG0571	ribonuclease III activity
H8Z71_14845	COG0481	GTPase activity
H8Z71_14850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8Z71_14865	COG1024	Enoyl-CoA hydratase
H8Z71_14865	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8Z71_14885	COG1024	Enoyl-CoA hydratase
H8Z71_14890	COG1960	acyl-CoA dehydrogenase activity
H8Z71_14910	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H8Z71_14915	COG3250	beta-galactosidase activity
H8Z71_14935	COG3209	COG3209 Rhs family protein
H8Z71_14945	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H8Z71_14955	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H8Z71_14975	COG0534	Mate efflux family protein
H8Z71_14980	COG0335	large ribosomal subunit rRNA binding
H8Z71_14985	COG0336	Belongs to the RNA methyltransferase TrmD family
H8Z71_14990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H8Z71_14995	COG0228	four-way junction DNA binding
H8Z71_15000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8Z71_15010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H8Z71_15015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8Z71_15045	COG4191	Histidine kinase
H8Z71_15045	COG0784	Response regulator, receiver
H8Z71_15050	COG2205	protein histidine kinase activity
H8Z71_15050	COG3437	response regulator, receiver
H8Z71_15050	COG3850	Histidine kinase
H8Z71_15050	COG4999	Histidine kinase
H8Z71_15055	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8Z71_15065	COG2205	protein histidine kinase activity
H8Z71_15070	COG5507	3-demethylubiquinone-9 3-methyltransferase
H8Z71_15080	COG4771	TonB-dependent receptor
H8Z71_15105	COG2172	sigma factor antagonist activity
H8Z71_15110	COG1366	Belongs to the anti-sigma-factor antagonist family
H8Z71_15115	COG1366	Belongs to the anti-sigma-factor antagonist family
H8Z71_15125	COG0326	Molecular chaperone. Has ATPase activity
H8Z71_15130	COG2207	Transcriptional regulator
H8Z71_15140	COG3152	Membrane
H8Z71_15155	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H8Z71_15160	COG1845	cytochrome c oxidase, subunit III
H8Z71_15165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H8Z71_15180	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H8Z71_15185	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H8Z71_15190	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H8Z71_15195	COG0196	riboflavin kinase activity
H8Z71_15205	COG0268	Binds directly to 16S ribosomal RNA
H8Z71_15210	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H8Z71_15215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H8Z71_15220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H8Z71_15225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H8Z71_15230	COG0824	Thioesterase
H8Z71_15245	COG1946	Acyl-CoA thioesterase
H8Z71_15265	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H8Z71_15275	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H8Z71_15300	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H8Z71_15315	COG2197	response regulator
H8Z71_15320	COG4585	Histidine kinase
H8Z71_15330	COG0850	regulation of cytokinetic process
H8Z71_15335	COG2894	cell division
H8Z71_15340	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H8Z71_15350	COG0642	Histidine kinase
H8Z71_15355	COG0745	RESPONSE REGULATOR receiver
H8Z71_15370	COG2194	sulfuric ester hydrolase activity
H8Z71_15385	COG2814	Major facilitator Superfamily
H8Z71_15390	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8Z71_15390	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8Z71_15400	COG0656	L-ascorbic acid biosynthetic process
H8Z71_15405	COG0753	catalase activity
H8Z71_15420	COG1917	Cupin 2, conserved barrel domain protein
H8Z71_15420	COG2207	Transcriptional regulator
H8Z71_15435	COG1506	peptidase
H8Z71_15435	COG0823	Involved in the tonB-independent uptake of proteins
H8Z71_15450	COG1297	OPT oligopeptide transporter protein
H8Z71_15470	COG0587	DNA-directed DNA polymerase activity
H8Z71_15485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8Z71_15520	COG2080	2 iron, 2 sulfur cluster binding
H8Z71_15525	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8Z71_15530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H8Z71_15555	COG0492	ferredoxin-NADP+ reductase activity
H8Z71_15575	COG3537	Alpha-1,2-mannosidase
H8Z71_15580	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_15585	COG3387	PFAM Glycoside hydrolase 15-related
H8Z71_15595	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8Z71_15670	COG1309	transcriptional regulator
H8Z71_15675	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_15680	COG0308	aminopeptidase N
H8Z71_15685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H8Z71_15695	COG0330	HflC and HflK could
H8Z71_15700	COG0330	HflC and HflK could
H8Z71_15720	COG0678	peroxiredoxin activity
H8Z71_15730	COG4953	penicillin-binding protein 1C
H8Z71_15745	COG2373	Large extracellular alpha-helical protein
H8Z71_15775	COG3609	addiction module antidote protein, CC2985 family
H8Z71_15795	COG3829	transcription factor binding
H8Z71_15820	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H8Z71_15825	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H8Z71_15840	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_15855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z71_15860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H8Z71_15865	COG1399	metal-binding, possibly nucleic acid-binding protein
H8Z71_15870	COG0424	maF-like protein
H8Z71_15890	COG0714	Associated with various cellular activities
H8Z71_15910	COG0537	adenosine 5'-monophosphoramidase activity
H8Z71_15915	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H8Z71_15920	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H8Z71_15965	COG0210	DNA helicase
H8Z71_16035	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H8Z71_16055	COG2003	Belongs to the UPF0758 family
H8Z71_16135	COG0314	molybdopterin synthase activity
H8Z71_16140	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H8Z71_16145	COG0315	cyclic pyranopterin monophosphate synthase activity
H8Z71_16155	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H8Z71_16160	COG1234	tRNA 3'-trailer cleavage
H8Z71_16165	COG3642	lipopolysaccharide core region biosynthetic process
H8Z71_16170	COG0859	PFAM glycosyl transferase family 9
H8Z71_16185	COG0631	protein serine/threonine phosphatase activity
H8Z71_16190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8Z71_16195	COG0328	RNA-DNA hybrid ribonuclease activity
H8Z71_16205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z71_16215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z71_16245	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H8Z71_16255	COG0544	peptidyl-prolyl cis-trans isomerase activity
H8Z71_16410	COG0473	3-isopropylmalate dehydrogenase activity
H8Z71_16425	COG4783	chaperone-mediated protein folding
H8Z71_16440	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H8Z71_16450	COG0438	transferase activity, transferring glycosyl groups
H8Z71_16455	COG0671	phosphoesterase, PA-phosphatase related
H8Z71_16460	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z71_16470	COG3291	Pkd domain containing protein
H8Z71_16480	COG2833	Protein of unknown function (DUF455)
H8Z71_16500	COG0285	dihydrofolate synthase activity
H8Z71_16505	COG0406	alpha-ribazole phosphatase activity
H8Z71_16535	COG1063	alcohol dehydrogenase
H8Z71_16545	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H8Z71_16550	COG4208	sulfate ABC transporter
H8Z71_16555	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H8Z71_16560	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H8Z71_16565	COG0156	8-amino-7-oxononanoate synthase activity
H8Z71_16590	COG0604	alcohol dehydrogenase
H8Z71_16595	COG0446	pyridine nucleotide-disulphide oxidoreductase
H8Z71_16595	COG1902	pentaerythritol trinitrate reductase activity
H8Z71_16605	COG0625	glutathione transferase activity
H8Z71_16610	COG0039	L-malate dehydrogenase activity
H8Z71_16615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8Z71_16620	COG1217	gtp-binding protein TYPA
H8Z71_16630	COG0154	amidase activity
H8Z71_16640	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H8Z71_16655	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H8Z71_16660	COG0203	ribosomal protein L17
H8Z71_16685	COG0201	protein transport
H8Z71_16690	COG0200	Binds to the 23S rRNA
H8Z71_16695	COG1841	ribosomal large subunit assembly
H8Z71_16705	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H8Z71_16710	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H8Z71_16715	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H8Z71_16725	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H8Z71_16730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H8Z71_16740	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H8Z71_16745	COG0255	Belongs to the universal ribosomal protein uL29 family
H8Z71_16750	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H8Z71_16755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H8Z71_16765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H8Z71_16770	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H8Z71_16775	COG0089	rRNA binding
H8Z71_16780	COG0088	Forms part of the polypeptide exit tunnel
H8Z71_16785	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H8Z71_16790	COG0051	transcription antitermination factor activity, RNA binding
H8Z71_16795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8Z71_16800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H8Z71_16805	COG0049	tRNA binding
H8Z71_16810	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H8Z71_16815	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8Z71_16820	COG0085	RNA polymerase activity
H8Z71_16825	COG0222	ribosome binding
H8Z71_16830	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H8Z71_16835	COG0081	regulation of translation
H8Z71_16840	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H8Z71_16845	COG0250	Participates in transcription elongation, termination and antitermination
H8Z71_16860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8Z71_16880	COG0012	GTP binding
H8Z71_16885	COG0193	aminoacyl-tRNA hydrolase activity
H8Z71_16890	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H8Z71_16895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H8Z71_16905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H8Z71_16910	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H8Z71_16920	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H8Z71_16925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H8Z71_16935	COG0521	Mo-molybdopterin cofactor biosynthetic process
H8Z71_16950	COG1254	Belongs to the acylphosphatase family
H8Z71_16955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z71_16960	COG1295	ribonuclease BN
H8Z71_16985	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H8Z71_16990	COG1404	Belongs to the peptidase S8 family
H8Z71_16995	COG1404	Belongs to the peptidase S8 family
H8Z71_17000	COG1404	Belongs to the peptidase S8 family
H8Z71_17005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8Z71_17020	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H8Z71_17045	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H8Z71_17075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8Z71_17075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8Z71_17095	COG2890	protein-(glutamine-N5) methyltransferase activity
H8Z71_17105	COG3634	alkyl hydroperoxide reductase activity
H8Z71_17110	COG0583	DNA-binding transcription factor activity
H8Z71_17115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z71_17120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8Z71_17130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8Z71_17140	COG2197	response regulator
H8Z71_17145	COG0784	Response regulator, receiver
H8Z71_17145	COG5002	protein histidine kinase activity
H8Z71_17145	COG2205	protein histidine kinase activity
H8Z71_17165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z71_17170	COG0697	spore germination
H8Z71_17195	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H8Z71_17210	COG3386	PFAM SMP-30 Gluconolaconase
H8Z71_17230	COG1024	Enoyl-CoA hydratase
H8Z71_17245	COG0583	DNA-binding transcription factor activity
H8Z71_17250	COG3384	dioxygenase
H8Z71_17280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z71_17285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z71_17300	COG2096	Adenosyltransferase
H8Z71_17305	COG0123	including yeast histone deacetylase and acetoin utilization protein
H8Z71_17320	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H8Z71_17325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z71_17330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H8Z71_17335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H8Z71_17340	COG2967	ApaG domain
H8Z71_17345	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H8Z71_17355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H8Z71_17365	COG0747	negative chemotaxis
H8Z71_17390	COG0431	NADPH-dependent FMN reductase
H8Z71_17395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z71_17405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z71_17410	COG1116	anion transmembrane transporter activity
H8Z71_17420	COG3829	transcription factor binding
H8Z71_17435	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H8Z71_17440	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H8Z71_17460	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H8Z71_17470	COG0642	Histidine kinase
H8Z71_17485	COG4181	ATPase activity
H8Z71_17495	COG2175	clavaminate synthase activity
H8Z71_17505	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H8Z71_17510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z71_17530	COG4771	TonB-dependent receptor
H8Z71_17540	COG0667	Aldo Keto reductase
H8Z71_17545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8Z71_17550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z71_17560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8Z71_17565	COG4106	trans-aconitate 2-methyltransferase activity
H8Z71_17575	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H8Z71_17615	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H8Z71_17625	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H8Z71_17630	COG2226	methyltransferase
H8Z71_17655	COG0366	Alpha amylase catalytic
H8Z71_17670	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_17670	COG0604	alcohol dehydrogenase
H8Z71_17670	COG3321	synthase
H8Z71_17690	COG0494	nUDIX hydrolase
H8Z71_17695	COG0653	protein targeting
H8Z71_17700	COG0739	heme binding
H8Z71_17710	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H8Z71_17725	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H8Z71_17730	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8Z71_17735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8Z71_17740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8Z71_17750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8Z71_17755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H8Z71_17760	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8Z71_17770	COG3116	cell division
H8Z71_17775	COG0275	rRNA processing
H8Z71_17810	COG0792	nuclease activity
H8Z71_17815	COG1988	membrane-bound metal-dependent
H8Z71_17820	COG0277	FAD linked oxidase domain protein
H8Z71_17840	COG0745	RESPONSE REGULATOR receiver
H8Z71_17845	COG2205	protein histidine kinase activity
H8Z71_17850	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H8Z71_17855	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H8Z71_17860	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H8Z71_17880	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H8Z71_17885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8Z71_17890	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H8Z71_17910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8Z71_17910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8Z71_17920	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H8Z71_17925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H8Z71_17935	COG0488	(ABC) transporter
H8Z71_17945	COG0697	spore germination
H8Z71_17955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8Z71_17970	COG3791	Glutathione-dependent formaldehyde-activating
H8Z71_18000	COG2205	protein histidine kinase activity
H8Z71_18015	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8Z71_18020	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H8Z71_18035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8Z71_18050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H8Z71_18055	COG1012	belongs to the aldehyde dehydrogenase family
H8Z71_18060	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H8Z71_18065	COG0617	tRNA 3'-terminal CCA addition
H8Z71_18075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H8Z71_18080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8Z71_18085	COG1609	Transcriptional regulator
H8Z71_18095	COG2188	Transcriptional regulator
H8Z71_18110	COG3250	beta-galactosidase activity
H8Z71_18160	COG1459	type II secretion system
H8Z71_18215	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H8Z71_18220	COG4191	Histidine kinase
H8Z71_18225	COG0784	Response regulator, receiver
H8Z71_18230	COG4251	negative regulation of phosphorylation
H8Z71_18235	COG2823	Periplasmic or secreted lipoprotein
H8Z71_18245	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H8Z71_18280	COG1051	belongs to the nudix hydrolase family
H8Z71_18280	COG1056	cytidyltransferase-related domain
H8Z71_18290	COG0583	DNA-binding transcription factor activity
H8Z71_18305	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8Z71_18310	COG0321	lipoyl(octanoyl) transferase activity
H8Z71_18315	COG2921	Belongs to the UPF0250 family
H8Z71_18325	COG1686	Belongs to the peptidase S11 family
H8Z71_18330	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H8Z71_18335	COG2951	lytic endotransglycosylase activity
H8Z71_18345	COG0772	Belongs to the SEDS family
H8Z71_18360	COG1792	Involved in formation and maintenance of cell shape
H8Z71_18365	COG1077	Cell shape determining protein MreB Mrl
H8Z71_18370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z71_18375	COG3284	Transcriptional regulator
H8Z71_18420	COG0308	aminopeptidase N
H8Z71_18425	COG3300	MHYT domain
H8Z71_18425	COG5001	Diguanylate cyclase
H8Z71_18430	COG2226	methyltransferase
H8Z71_18455	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H8Z71_18460	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H8Z71_18465	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H8Z71_18475	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H8Z71_18485	COG2832	Protein of unknown function (DUF454)
H8Z71_18495	COG0436	Aminotransferase
H8Z71_18500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8Z71_18505	COG1505	serine-type exopeptidase activity
H8Z71_18530	COG0181	hydroxymethylbilane synthase activity
H8Z71_18540	COG3275	phosphorelay sensor kinase activity
H8Z71_18550	COG2943	transferase activity, transferring hexosyl groups
H8Z71_18565	COG0659	secondary active sulfate transmembrane transporter activity
H8Z71_18570	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z71_18570	COG5297	Belongs to the glycosyl hydrolase family 6
H8Z71_18575	COG0840	transmembrane signaling receptor activity
H8Z71_18580	COG5001	Diguanylate cyclase
H8Z71_18615	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H8Z71_18635	COG1113	amino acid transport
H8Z71_18650	COG0697	spore germination
H8Z71_18690	COG1506	peptidase
H8Z71_18690	COG0823	Involved in the tonB-independent uptake of proteins
H8Z71_18695	COG2409	Drug exporters of the RND superfamily
H8Z71_18720	COG0435	Glutathione S-transferase
H8Z71_18730	COG4221	oxidoreductase activity
H8Z71_18745	COG4221	oxidoreductase activity
H8Z71_18800	COG1802	Transcriptional regulator
H8Z71_18810	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8Z71_18835	COG3052	prosthetic group binding
H8Z71_18865	COG2353	YceI-like domain
H8Z71_18870	COG0778	Nitroreductase
H8Z71_18885	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8Z71_18890	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H8Z71_18900	COG3386	PFAM SMP-30 Gluconolaconase
H8Z71_18915	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H8Z71_18930	COG0459	protein refolding
H8Z71_18945	COG2356	endonuclease I
H8Z71_18950	COG0300	oxidoreductase activity
H8Z71_18975	COG1324	tolerance protein
H8Z71_18985	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H8Z71_18990	COG0511	ligase activity, forming carbon-carbon bonds
H8Z71_19000	COG0439	Biotin carboxylase
H8Z71_19015	COG2264	protein methyltransferase activity
H8Z71_19035	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H8Z71_19040	COG4589	Belongs to the CDS family
H8Z71_19065	COG0671	phosphoesterase, PA-phosphatase related
H8Z71_19065	COG2453	phosphatase
H8Z71_19070	COG2267	carboxylic ester hydrolase activity
H8Z71_19075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8Z71_19080	COG0138	bifunctional purine biosynthesis protein purh
H8Z71_19090	COG0151	Belongs to the GarS family
H8Z71_19100	COG1289	transmembrane transporter activity
H8Z71_19105	COG2814	Major facilitator Superfamily
H8Z71_19110	COG0583	DNA-binding transcription factor activity
H8Z71_19115	COG2814	Major facilitator Superfamily
H8Z71_19130	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8Z71_19145	COG0316	Belongs to the HesB IscA family
H8Z71_19185	COG1051	belongs to the nudix hydrolase family
H8Z71_19200	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H8Z71_19210	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H8Z71_19220	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H8Z71_19225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z71_19235	COG0134	indole-3-glycerol-phosphate synthase activity
H8Z71_19240	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8Z71_19265	COG1597	lipid kinase activity
H8Z71_19270	COG0456	acetyltransferase
H8Z71_19285	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H8Z71_19290	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H8Z71_19310	COG3179	chitinase
H8Z71_19330	COG2111	Na H antiporter
H8Z71_19330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8Z71_19335	COG1006	Multisubunit Na H antiporter MnhC subunit
H8Z71_19340	COG0651	ATP synthesis coupled electron transport
H8Z71_19350	COG2212	antiporter activity
H8Z71_19355	COG1320	monovalent cation:proton antiporter activity
H8Z71_19370	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H8Z71_19395	COG3104	oligopeptide transport
H8Z71_19400	COG3483	tryptophan 2,3-dioxygenase activity
H8Z71_19410	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H8Z71_19425	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8Z71_19435	COG0513	Belongs to the DEAD box helicase family
H8Z71_19445	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_19450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z71_19480	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_19485	COG0702	epimerase
H8Z71_19510	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z71_19515	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z71_19520	COG0297	glycogen (starch) synthase activity
H8Z71_19530	COG2354	Protein conserved in bacteria
H8Z71_19535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8Z71_19540	COG1368	sulfuric ester hydrolase activity
H8Z71_19545	COG1511	domain protein
H8Z71_19545	COG3264	Mechanosensitive ion channel
H8Z71_19615	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8Z71_19695	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8Z71_19700	COG1040	competence protein
H8Z71_19705	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H8Z71_19710	COG0156	8-amino-7-oxononanoate synthase activity
H8Z71_19720	COG2267	carboxylic ester hydrolase activity
H8Z71_19750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H8Z71_19760	COG0445	tRNA wobble uridine modification
H8Z71_19770	COG0657	acetylesterase activity
H8Z71_19780	COG1414	Transcriptional regulator
H8Z71_19790	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H8Z71_19795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z71_19805	COG3485	protocatechuate 3,4-dioxygenase
H8Z71_19810	COG3485	protocatechuate 3,4-dioxygenase
H8Z71_19820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H8Z71_19825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H8Z71_19850	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H8Z71_19855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H8Z71_19910	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H8Z71_19925	COG0129	dihydroxy-acid dehydratase activity
H8Z71_19955	COG1733	regulation of RNA biosynthetic process
H8Z71_19960	COG0702	epimerase
H8Z71_19990	COG0583	DNA-binding transcription factor activity
H8Z71_19995	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8Z71_20000	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H8Z71_20020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z71_20025	COG2205	protein histidine kinase activity
H8Z71_20030	COG0745	RESPONSE REGULATOR receiver
H8Z71_20050	COG1902	pentaerythritol trinitrate reductase activity
H8Z71_20055	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H8Z71_20070	COG2814	Major facilitator Superfamily
H8Z71_20075	COG0583	DNA-binding transcription factor activity
H8Z71_20090	COG0084	hydrolase, TatD family'
H8Z71_20110	COG2252	PERMEase
H8Z71_20120	COG1957	nucleoside hydrolase
H8Z71_20155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H8Z71_20175	COG2072	flavoprotein involved in K transport
H8Z71_20180	COG2351	hydroxyisourate hydrolase activity
H8Z71_20185	COG4807	Protein conserved in bacteria
H8Z71_20190	COG1643	Atp-dependent helicase
H8Z71_20205	COG1187	pseudouridine synthase activity
H8Z71_20220	COG2130	NADP-dependent
H8Z71_20245	COG1764	response to oxidative stress
H8Z71_20250	COG1846	Transcriptional regulator
H8Z71_20255	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H8Z71_20265	COG0697	spore germination
H8Z71_20275	COG0523	cobalamin synthesis protein
H8Z71_20335	COG1960	acyl-CoA dehydrogenase activity
H8Z71_20340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H8Z71_20345	COG4770	biotin carboxylase activity
H8Z71_20375	COG2224	Isocitrate lyase
H8Z71_20380	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H8Z71_20385	COG0583	DNA-binding transcription factor activity
H8Z71_20390	COG0475	glutathione-regulated potassium exporter activity
H8Z71_20420	COG0339	signal peptide processing
H8Z71_20455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8Z71_20465	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8Z71_20475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z71_20480	COG0318	PFAM AMP-dependent synthetase and ligase
H8Z71_20485	COG0727	PFAM Uncharacterised protein family (UPF0153)
H8Z71_20490	COG0596	Alpha beta hydrolase
H8Z71_20500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z71_20515	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H8Z71_20540	COG2205	protein histidine kinase activity
H8Z71_20545	COG0028	Belongs to the TPP enzyme family
H8Z71_20560	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H8Z71_20565	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H8Z71_20570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8Z71_20605	COG0183	Belongs to the thiolase family
H8Z71_20615	COG0346	lactoylglutathione lyase activity
H8Z71_20625	COG2032	superoxide dismutase activity
H8Z71_20630	COG2032	superoxide dismutase activity
H8Z71_20635	COG2204	response regulator
H8Z71_20640	COG3852	Histidine kinase
H8Z71_20645	COG0004	ammonium transporteR
H8Z71_20650	COG0347	Belongs to the P(II) protein family
H8Z71_20655	COG0174	glutamine synthetase
H8Z71_20660	COG1968	undecaprenyl-diphosphatase activity
H8Z71_20705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z71_20715	COG2062	phosphohistidine phosphatase, SixA
H8Z71_20720	COG0489	protein tyrosine kinase activity
H8Z71_20740	COG1396	sequence-specific DNA binding
H8Z71_20760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8Z71_20775	COG1125	glycine betaine transport
H8Z71_20840	COG3237	CsbD-like
H8Z71_20885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z71_20890	COG0477	Major facilitator Superfamily
H8Z71_20930	COG0714	Associated with various cellular activities
H8Z71_20965	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H8Z71_20975	COG4772	TonB-dependent receptor
H8Z71_20985	COG0662	Cupin 2, conserved barrel domain protein
H8Z71_20990	COG1012	belongs to the aldehyde dehydrogenase family
H8Z71_21015	COG1304	FMN binding
H8Z71_21025	COG4585	Histidine kinase
H8Z71_21030	COG2197	response regulator
H8Z71_21050	COG3710	Transcriptional regulator
H8Z71_21055	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H8Z71_21170	COG0210	DNA helicase
H8Z71_21180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z71_21185	COG0583	DNA-binding transcription factor activity
H8Z71_21190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H8Z71_21200	COG2159	amidohydrolase
H8Z71_21220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z71_21240	COG0357	Ribosomal RNA small subunit methyltransferase G
H8Z71_21245	COG3540	Alkaline phosphatase
H8Z71_21255	COG2091	lysine biosynthetic process via aminoadipic acid
H8Z71_21270	COG0708	Exodeoxyribonuclease III
H8Z71_21275	COG1940	carbohydrate kinase activity
H8Z71_21275	COG1846	Transcriptional regulator
H8Z71_21285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z71_21295	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8Z71_21300	COG3162	membrane
H8Z71_21310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8Z71_21335	COG3507	Belongs to the glycosyl hydrolase 43 family
H8Z71_21355	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z71_21360	COG0179	Fumarylacetoacetate (FAA) hydrolase
H8Z71_21365	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z71_21370	COG3254	rhamnose metabolic process
H8Z71_21375	COG0738	Major facilitator superfamily
H8Z71_21380	COG1414	Transcriptional regulator
H8Z71_21385	COG1971	Probably functions as a manganese efflux pump
H8Z71_21390	COG2205	protein histidine kinase activity
H8Z71_21400	COG3459	Glycosyltransferase 36 associated
H8Z71_21405	COG2211	Major facilitator Superfamily
H8Z71_21410	COG3265	gluconokinase activity
H8Z71_21415	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z71_21435	COG2911	Protein conserved in bacteria
H8Z71_21440	COG0729	surface antigen
H8Z71_21490	COG0752	glycyl-tRNA synthetase alpha subunit
H8Z71_21495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z71_21505	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z71_21505	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8Z71_21515	COG0805	protein transport
H8Z71_21520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8Z71_21525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8Z71_21535	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8Z71_21555	COG2974	May be involved in recombination
H8Z71_21560	COG0037	tRNA processing
H8Z71_21565	COG2115	Belongs to the xylose isomerase family
H8Z71_21575	COG3661	Belongs to the glycosyl hydrolase 67 family
H8Z71_21585	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z71_21595	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z71_21600	COG0246	Mannitol dehydrogenase
H8Z71_21645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8Z71_21675	COG3386	PFAM SMP-30 Gluconolaconase
H8Z71_21685	COG3250	beta-galactosidase activity
H8Z71_21690	COG1904	glucuronate isomerase
H8Z71_21695	COG3693	PFAM glycoside hydrolase, family 10
H8Z71_21705	COG3693	PFAM glycoside hydrolase, family 10
H8Z71_21720	COG2211	Major facilitator Superfamily
H8Z71_21790	COG2937	Belongs to the GPAT DAPAT family
H8Z71_21820	COG0284	orotidine-5'-phosphate decarboxylase activity
H8Z71_21825	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H8Z71_21830	COG3132	Protein of unknown function, DUF480
H8Z71_21845	COG0210	DNA helicase
H8Z71_21850	COG1435	thymidine kinase activity
H8Z71_21860	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H8Z71_21870	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H8Z71_21900	COG3135	benzoate transporter
H8Z71_21920	COG0676	glucose-6-phosphate 1-epimerase activity
H8Z71_21930	COG3012	SEC-C Motif Domain Protein
H8Z71_21935	COG0730	response to heat
H8Z71_21955	COG0302	gtp cyclohydrolase
H8Z71_21970	COG1566	PFAM secretion protein HlyD family protein
H8Z71_21980	COG1289	transmembrane transporter activity
H8Z71_21985	COG0477	Major facilitator Superfamily
H8Z71_21995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z71_22015	COG4691	Plasmid stability protein
H8Z71_22020	COG1487	ribonuclease activity
H8Z71_22055	COG0564	pseudouridine synthase activity
H8Z71_22085	COG0439	Biotin carboxylase
H8Z71_22130	COG1074	ATP-dependent DNA helicase activity
H8Z71_22135	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H8Z71_22150	COG1127	ABC transporter
H8Z71_22155	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8Z71_22160	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8Z71_22175	COG2853	Lipoprotein
H8Z71_22185	COG0386	Belongs to the glutathione peroxidase family
H8Z71_22195	COG1322	Protein conserved in bacteria
H8Z71_22200	COG0604	alcohol dehydrogenase
H8Z71_22215	COG0625	glutathione transferase activity
H8Z71_22225	COG0531	amino acid
H8Z71_22230	COG3537	Alpha-1,2-mannosidase
H8Z71_22240	COG3706	GGDEF domain
H8Z71_22245	COG3835	regulator
H8Z71_22250	COG1929	Belongs to the glycerate kinase type-1 family
H8Z71_22255	COG2271	Major facilitator Superfamily
H8Z71_22270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H8Z71_22275	COG0861	Integral membrane protein TerC family
H8Z71_22285	COG0584	glycerophosphoryl diester phosphodiesterase
H8Z71_22300	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H8Z71_22305	COG0726	polysaccharide deacetylase
H8Z71_22310	COG0706	membrane insertase activity
H8Z71_22315	COG0594	ribonuclease P activity
H8Z71_22410	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z71_22430	COG3012	SEC-C Motif Domain Protein
H8Z71_22430	COG3318	Belongs to the UPF0149 family
H8Z71_22450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z71_22455	COG4456	Virulence-associated protein
H8Z71_22535	COG2948	multi-organism process
H8Z71_22540	COG3504	Conjugal transfer protein
H8Z71_22550	COG3704	protein secretion by the type IV secretion system
H8Z71_22690	COG3451	type IV secretory pathway VirB4
H8Z71_22705	COG4962	Type ii secretion system protein e
H8Z71_22775	COG0489	protein tyrosine kinase activity
H8Z71_22855	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8Z71_22915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z71_22945	COG3701	Conjugal transfer protein
H8Z71_22985	COG3704	protein secretion by the type IV secretion system
H8Z71_22995	COG3504	Conjugal transfer protein
H8Z71_23000	COG2948	multi-organism process
H8Z71_23020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z71_23090	COG3041	Addiction module toxin RelE StbE family
H8Z71_23095	COG3077	Addiction module antitoxin, RelB DinJ family
H8Z71_23110	COG1192	Involved in chromosome partitioning
H8Z71_23175	COG1192	Involved in chromosome partitioning
H8Z71_23220	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z71_23240	COG3012	SEC-C Motif Domain Protein
H8Z71_23240	COG3318	Belongs to the UPF0149 family