locus-tag	class	description
H8Z72_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H8Z72_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8Z72_00020	COG0187	DNA topoisomerase II activity
H8Z72_00030	COG0501	Belongs to the peptidase M48B family
H8Z72_00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H8Z72_00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z72_00115	COG0793	Belongs to the peptidase S41A family
H8Z72_00120	COG4942	peptidase
H8Z72_00130	COG2234	aminopeptidase activity
H8Z72_00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z72_00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z72_00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z72_00165	COG1064	alcohol dehydrogenase
H8Z72_00175	COG0493	'glutamate synthase
H8Z72_00180	COG0070	glutamate synthase
H8Z72_00180	COG0069	glutamate synthase activity
H8Z72_00180	COG0067	glutamate synthase
H8Z72_00230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8Z72_00245	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H8Z72_00250	COG0297	glycogen (starch) synthase activity
H8Z72_00250	COG0438	transferase activity, transferring glycosyl groups
H8Z72_00270	COG0367	asparagine synthase
H8Z72_00300	COG1132	(ABC) transporter
H8Z72_00330	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H8Z72_00415	COG1205	dead DEAH box helicase
H8Z72_00415	COG1111	helicase
H8Z72_00420	COG1272	protein, Hemolysin III
H8Z72_00440	COG0300	oxidoreductase activity
H8Z72_00445	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z72_00465	COG2249	NAD(P)H dehydrogenase (quinone) activity
H8Z72_00520	COG3237	CsbD-like
H8Z72_00565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z72_00570	COG0477	Major facilitator Superfamily
H8Z72_00610	COG0714	Associated with various cellular activities
H8Z72_00640	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H8Z72_00650	COG4772	TonB-dependent receptor
H8Z72_00660	COG0662	Cupin 2, conserved barrel domain protein
H8Z72_00665	COG1012	belongs to the aldehyde dehydrogenase family
H8Z72_00690	COG1304	FMN binding
H8Z72_00700	COG4585	Histidine kinase
H8Z72_00705	COG2197	response regulator
H8Z72_00725	COG3710	Transcriptional regulator
H8Z72_00730	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H8Z72_00805	COG0366	Alpha amylase catalytic
H8Z72_00810	COG0366	Alpha amylase catalytic
H8Z72_00815	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z72_00835	COG2755	lipolytic protein G-D-S-L family
H8Z72_00835	COG0657	acetylesterase activity
H8Z72_00845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H8Z72_00860	COG3507	Belongs to the glycosyl hydrolase 43 family
H8Z72_00865	COG1609	Transcriptional regulator
H8Z72_00870	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H8Z72_00875	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z72_00885	COG2755	lipolytic protein G-D-S-L family
H8Z72_00900	COG3186	Phenylalanine-4-hydroxylase
H8Z72_00905	COG1522	sequence-specific DNA binding
H8Z72_00915	COG1752	Esterase of the alpha-beta hydrolase superfamily
H8Z72_00925	COG1119	ATPase activity
H8Z72_00940	COG1125	glycine betaine transport
H8Z72_00955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8Z72_00975	COG1396	sequence-specific DNA binding
H8Z72_00995	COG0489	protein tyrosine kinase activity
H8Z72_01000	COG2062	phosphohistidine phosphatase, SixA
H8Z72_01010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z72_01055	COG1968	undecaprenyl-diphosphatase activity
H8Z72_01060	COG0174	glutamine synthetase
H8Z72_01065	COG0347	Belongs to the P(II) protein family
H8Z72_01070	COG0004	ammonium transporteR
H8Z72_01075	COG3852	Histidine kinase
H8Z72_01080	COG2204	response regulator
H8Z72_01085	COG2032	superoxide dismutase activity
H8Z72_01090	COG2032	superoxide dismutase activity
H8Z72_01100	COG0346	lactoylglutathione lyase activity
H8Z72_01110	COG0183	Belongs to the thiolase family
H8Z72_01145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8Z72_01150	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H8Z72_01155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H8Z72_01170	COG0028	Belongs to the TPP enzyme family
H8Z72_01175	COG2205	protein histidine kinase activity
H8Z72_01200	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H8Z72_01215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z72_01225	COG0596	Alpha beta hydrolase
H8Z72_01230	COG0727	PFAM Uncharacterised protein family (UPF0153)
H8Z72_01235	COG0318	PFAM AMP-dependent synthetase and ligase
H8Z72_01240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z72_01250	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8Z72_01260	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8Z72_01295	COG0339	signal peptide processing
H8Z72_01325	COG0475	glutathione-regulated potassium exporter activity
H8Z72_01330	COG0583	DNA-binding transcription factor activity
H8Z72_01335	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H8Z72_01340	COG2224	Isocitrate lyase
H8Z72_01375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H8Z72_01380	COG1960	acyl-CoA dehydrogenase activity
H8Z72_01435	COG0523	cobalamin synthesis protein
H8Z72_01445	COG0697	spore germination
H8Z72_01455	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H8Z72_01460	COG1846	Transcriptional regulator
H8Z72_01465	COG1764	response to oxidative stress
H8Z72_01490	COG2130	NADP-dependent
H8Z72_01505	COG1187	pseudouridine synthase activity
H8Z72_01520	COG1643	Atp-dependent helicase
H8Z72_01525	COG4807	Protein conserved in bacteria
H8Z72_01530	COG2351	hydroxyisourate hydrolase activity
H8Z72_01535	COG2072	flavoprotein involved in K transport
H8Z72_01555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H8Z72_01590	COG1957	nucleoside hydrolase
H8Z72_01600	COG2252	PERMEase
H8Z72_01620	COG0084	hydrolase, TatD family'
H8Z72_01635	COG0583	DNA-binding transcription factor activity
H8Z72_01640	COG2814	Major facilitator Superfamily
H8Z72_01655	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H8Z72_01660	COG1902	pentaerythritol trinitrate reductase activity
H8Z72_01680	COG0745	RESPONSE REGULATOR receiver
H8Z72_01685	COG2205	protein histidine kinase activity
H8Z72_01690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z72_01710	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H8Z72_01715	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8Z72_01720	COG0583	DNA-binding transcription factor activity
H8Z72_01750	COG0702	epimerase
H8Z72_01755	COG1733	regulation of RNA biosynthetic process
H8Z72_01785	COG0129	dihydroxy-acid dehydratase activity
H8Z72_01800	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H8Z72_01855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H8Z72_01860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H8Z72_01885	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H8Z72_01890	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H8Z72_01900	COG3485	protocatechuate 3,4-dioxygenase
H8Z72_01905	COG3485	protocatechuate 3,4-dioxygenase
H8Z72_01915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z72_01920	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H8Z72_01930	COG1414	Transcriptional regulator
H8Z72_01940	COG0657	acetylesterase activity
H8Z72_01950	COG0445	tRNA wobble uridine modification
H8Z72_01960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H8Z72_01990	COG2267	carboxylic ester hydrolase activity
H8Z72_02000	COG0156	8-amino-7-oxononanoate synthase activity
H8Z72_02005	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H8Z72_02010	COG1040	competence protein
H8Z72_02015	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8Z72_02095	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8Z72_02165	COG1511	domain protein
H8Z72_02165	COG3264	Mechanosensitive ion channel
H8Z72_02170	COG1368	sulfuric ester hydrolase activity
H8Z72_02175	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8Z72_02180	COG2354	Protein conserved in bacteria
H8Z72_02190	COG0297	glycogen (starch) synthase activity
H8Z72_02195	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z72_02200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z72_02225	COG0702	epimerase
H8Z72_02230	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z72_02260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z72_02265	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z72_02275	COG0513	Belongs to the DEAD box helicase family
H8Z72_02300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H8Z72_02310	COG3483	tryptophan 2,3-dioxygenase activity
H8Z72_02315	COG3104	oligopeptide transport
H8Z72_02340	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H8Z72_02355	COG1320	monovalent cation:proton antiporter activity
H8Z72_02360	COG2212	antiporter activity
H8Z72_02370	COG0651	ATP synthesis coupled electron transport
H8Z72_02375	COG1006	Multisubunit Na H antiporter MnhC subunit
H8Z72_02380	COG2111	Na H antiporter
H8Z72_02380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8Z72_02400	COG3179	chitinase
H8Z72_02420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H8Z72_02425	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H8Z72_02440	COG0456	acetyltransferase
H8Z72_02445	COG1597	lipid kinase activity
H8Z72_02470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8Z72_02475	COG0134	indole-3-glycerol-phosphate synthase activity
H8Z72_02485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z72_02490	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H8Z72_02500	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H8Z72_02510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H8Z72_02525	COG1051	belongs to the nudix hydrolase family
H8Z72_02565	COG0316	Belongs to the HesB IscA family
H8Z72_02580	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8Z72_02600	COG2814	Major facilitator Superfamily
H8Z72_02605	COG0583	DNA-binding transcription factor activity
H8Z72_02610	COG2814	Major facilitator Superfamily
H8Z72_02615	COG1289	transmembrane transporter activity
H8Z72_02620	COG0151	Belongs to the GarS family
H8Z72_02630	COG0138	bifunctional purine biosynthesis protein purh
H8Z72_02635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8Z72_02640	COG2267	carboxylic ester hydrolase activity
H8Z72_02645	COG2453	phosphatase
H8Z72_02645	COG0671	phosphoesterase, PA-phosphatase related
H8Z72_02670	COG4589	Belongs to the CDS family
H8Z72_02675	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H8Z72_02710	COG0439	Biotin carboxylase
H8Z72_02720	COG0511	ligase activity, forming carbon-carbon bonds
H8Z72_02725	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H8Z72_02735	COG1324	tolerance protein
H8Z72_02760	COG0300	oxidoreductase activity
H8Z72_02765	COG2356	endonuclease I
H8Z72_02780	COG0459	protein refolding
H8Z72_02795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H8Z72_02810	COG3386	PFAM SMP-30 Gluconolaconase
H8Z72_02820	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H8Z72_02825	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8Z72_02840	COG0778	Nitroreductase
H8Z72_02845	COG2353	YceI-like domain
H8Z72_02875	COG3052	prosthetic group binding
H8Z72_02900	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8Z72_02910	COG1802	Transcriptional regulator
H8Z72_02965	COG4221	oxidoreductase activity
H8Z72_02980	COG4221	oxidoreductase activity
H8Z72_02990	COG0435	Glutathione S-transferase
H8Z72_03015	COG2409	Drug exporters of the RND superfamily
H8Z72_03020	COG1506	peptidase
H8Z72_03020	COG0823	Involved in the tonB-independent uptake of proteins
H8Z72_03060	COG0697	spore germination
H8Z72_03075	COG1113	amino acid transport
H8Z72_03095	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H8Z72_03130	COG5001	Diguanylate cyclase
H8Z72_03135	COG0840	transmembrane signaling receptor activity
H8Z72_03140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z72_03140	COG5297	Belongs to the glycosyl hydrolase family 6
H8Z72_03145	COG0659	secondary active sulfate transmembrane transporter activity
H8Z72_03160	COG2943	transferase activity, transferring hexosyl groups
H8Z72_03170	COG3275	phosphorelay sensor kinase activity
H8Z72_03180	COG0181	hydroxymethylbilane synthase activity
H8Z72_03210	COG0436	Aminotransferase
H8Z72_03220	COG2832	Protein of unknown function (DUF454)
H8Z72_03230	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H8Z72_03240	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H8Z72_03245	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H8Z72_03250	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H8Z72_03275	COG2226	methyltransferase
H8Z72_03280	COG5001	Diguanylate cyclase
H8Z72_03280	COG3300	MHYT domain
H8Z72_03285	COG0308	aminopeptidase N
H8Z72_03330	COG3284	Transcriptional regulator
H8Z72_03335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z72_03340	COG1077	Cell shape determining protein MreB Mrl
H8Z72_03345	COG1792	Involved in formation and maintenance of cell shape
H8Z72_03360	COG0772	Belongs to the SEDS family
H8Z72_03370	COG2951	lytic endotransglycosylase activity
H8Z72_03375	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H8Z72_03380	COG1686	Belongs to the peptidase S11 family
H8Z72_03390	COG2921	Belongs to the UPF0250 family
H8Z72_03395	COG0321	lipoyl(octanoyl) transferase activity
H8Z72_03400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8Z72_03415	COG0583	DNA-binding transcription factor activity
H8Z72_03425	COG1051	belongs to the nudix hydrolase family
H8Z72_03425	COG1056	cytidyltransferase-related domain
H8Z72_03460	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H8Z72_03465	COG0673	inositol 2-dehydrogenase activity
H8Z72_03470	COG2823	Periplasmic or secreted lipoprotein
H8Z72_03475	COG4251	negative regulation of phosphorylation
H8Z72_03480	COG0784	Response regulator, receiver
H8Z72_03485	COG4191	Histidine kinase
H8Z72_03490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H8Z72_03545	COG1459	type II secretion system
H8Z72_03595	COG3250	beta-galactosidase activity
H8Z72_03610	COG2188	Transcriptional regulator
H8Z72_03620	COG1609	Transcriptional regulator
H8Z72_03625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8Z72_03630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H8Z72_03640	COG0617	tRNA 3'-terminal CCA addition
H8Z72_03645	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H8Z72_03650	COG1012	belongs to the aldehyde dehydrogenase family
H8Z72_03655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H8Z72_03670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8Z72_03685	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H8Z72_03690	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8Z72_03705	COG2205	protein histidine kinase activity
H8Z72_03735	COG3791	Glutathione-dependent formaldehyde-activating
H8Z72_03750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8Z72_03760	COG0697	spore germination
H8Z72_03770	COG0488	(ABC) transporter
H8Z72_03780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H8Z72_03785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H8Z72_03795	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8Z72_03795	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8Z72_03815	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H8Z72_03820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8Z72_03825	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H8Z72_03845	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H8Z72_03850	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H8Z72_03855	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H8Z72_03860	COG2205	protein histidine kinase activity
H8Z72_03865	COG0745	RESPONSE REGULATOR receiver
H8Z72_03880	COG0277	FAD linked oxidase domain protein
H8Z72_03885	COG1988	membrane-bound metal-dependent
H8Z72_03890	COG0792	nuclease activity
H8Z72_03925	COG0275	rRNA processing
H8Z72_03930	COG3116	cell division
H8Z72_03940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8Z72_03945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H8Z72_03950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8Z72_03960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8Z72_03965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8Z72_03970	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8Z72_03975	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H8Z72_03990	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H8Z72_04000	COG0739	heme binding
H8Z72_04005	COG0653	protein targeting
H8Z72_04010	COG0494	nUDIX hydrolase
H8Z72_04020	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H8Z72_04030	COG0604	alcohol dehydrogenase
H8Z72_04030	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z72_04030	COG3321	synthase
H8Z72_04045	COG0366	Alpha amylase catalytic
H8Z72_04070	COG2226	methyltransferase
H8Z72_04075	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H8Z72_04085	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H8Z72_04125	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H8Z72_04135	COG4106	trans-aconitate 2-methyltransferase activity
H8Z72_04140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8Z72_04150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z72_04155	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8Z72_04160	COG0667	Aldo Keto reductase
H8Z72_04170	COG4771	TonB-dependent receptor
H8Z72_04190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z72_04195	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H8Z72_04205	COG2175	clavaminate synthase activity
H8Z72_04215	COG4181	ATPase activity
H8Z72_04240	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H8Z72_04260	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H8Z72_04265	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H8Z72_04280	COG3829	transcription factor binding
H8Z72_04290	COG1116	anion transmembrane transporter activity
H8Z72_04295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z72_04305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z72_04310	COG0431	NADPH-dependent FMN reductase
H8Z72_04335	COG0747	negative chemotaxis
H8Z72_04345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H8Z72_04355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H8Z72_04360	COG2967	ApaG domain
H8Z72_04365	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H8Z72_04370	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H8Z72_04375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z72_04380	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H8Z72_04395	COG0123	including yeast histone deacetylase and acetoin utilization protein
H8Z72_04400	COG2096	Adenosyltransferase
H8Z72_04415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z72_04420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z72_04450	COG3384	dioxygenase
H8Z72_04455	COG0583	DNA-binding transcription factor activity
H8Z72_04470	COG1024	Enoyl-CoA hydratase
H8Z72_04490	COG3386	PFAM SMP-30 Gluconolaconase
H8Z72_04505	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H8Z72_04530	COG0697	spore germination
H8Z72_04535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z72_04555	COG5002	protein histidine kinase activity
H8Z72_04555	COG2205	protein histidine kinase activity
H8Z72_04555	COG0784	Response regulator, receiver
H8Z72_04560	COG2197	response regulator
H8Z72_04570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8Z72_04580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8Z72_04585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z72_04590	COG0583	DNA-binding transcription factor activity
H8Z72_04595	COG3634	alkyl hydroperoxide reductase activity
H8Z72_04605	COG2890	protein-(glutamine-N5) methyltransferase activity
H8Z72_04625	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8Z72_04625	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8Z72_04655	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H8Z72_04680	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H8Z72_04695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8Z72_04700	COG1404	Belongs to the peptidase S8 family
H8Z72_04705	COG1404	Belongs to the peptidase S8 family
H8Z72_04710	COG1404	Belongs to the peptidase S8 family
H8Z72_04715	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H8Z72_04740	COG1295	ribonuclease BN
H8Z72_04745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z72_04750	COG1254	Belongs to the acylphosphatase family
H8Z72_04765	COG0521	Mo-molybdopterin cofactor biosynthetic process
H8Z72_04775	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H8Z72_04780	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H8Z72_04790	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H8Z72_04795	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H8Z72_04805	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H8Z72_04810	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H8Z72_04815	COG0193	aminoacyl-tRNA hydrolase activity
H8Z72_04820	COG0012	GTP binding
H8Z72_04840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8Z72_04855	COG0250	Participates in transcription elongation, termination and antitermination
H8Z72_04860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H8Z72_04865	COG0081	regulation of translation
H8Z72_04870	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H8Z72_04875	COG0222	ribosome binding
H8Z72_04880	COG0085	RNA polymerase activity
H8Z72_04885	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8Z72_04890	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H8Z72_04895	COG0049	tRNA binding
H8Z72_04900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H8Z72_04905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8Z72_04910	COG0051	transcription antitermination factor activity, RNA binding
H8Z72_04915	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H8Z72_04920	COG0088	Forms part of the polypeptide exit tunnel
H8Z72_04925	COG0089	rRNA binding
H8Z72_04930	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H8Z72_04935	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H8Z72_04945	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H8Z72_04950	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H8Z72_04955	COG0255	Belongs to the universal ribosomal protein uL29 family
H8Z72_04960	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H8Z72_04970	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H8Z72_04975	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H8Z72_04985	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H8Z72_04990	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H8Z72_04995	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H8Z72_05005	COG1841	ribosomal large subunit assembly
H8Z72_05010	COG0200	Binds to the 23S rRNA
H8Z72_05015	COG0201	protein transport
H8Z72_05040	COG0203	ribosomal protein L17
H8Z72_05045	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H8Z72_05060	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H8Z72_05070	COG0154	amidase activity
H8Z72_05080	COG1217	gtp-binding protein TYPA
H8Z72_05085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8Z72_05090	COG0039	L-malate dehydrogenase activity
H8Z72_05095	COG0625	glutathione transferase activity
H8Z72_05105	COG0446	pyridine nucleotide-disulphide oxidoreductase
H8Z72_05105	COG1902	pentaerythritol trinitrate reductase activity
H8Z72_05110	COG0604	alcohol dehydrogenase
H8Z72_05135	COG0156	8-amino-7-oxononanoate synthase activity
H8Z72_05140	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H8Z72_05145	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H8Z72_05150	COG4208	sulfate ABC transporter
H8Z72_05155	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H8Z72_05165	COG1063	alcohol dehydrogenase
H8Z72_05195	COG0406	alpha-ribazole phosphatase activity
H8Z72_05200	COG0285	dihydrofolate synthase activity
H8Z72_05220	COG2833	Protein of unknown function (DUF455)
H8Z72_05230	COG3291	Pkd domain containing protein
H8Z72_05240	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z72_05245	COG0671	phosphoesterase, PA-phosphatase related
H8Z72_05250	COG0438	transferase activity, transferring glycosyl groups
H8Z72_05260	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H8Z72_05275	COG4783	chaperone-mediated protein folding
H8Z72_05290	COG0473	3-isopropylmalate dehydrogenase activity
H8Z72_05385	COG2801	Transposase and inactivated derivatives
H8Z72_05410	COG0544	peptidyl-prolyl cis-trans isomerase activity
H8Z72_05420	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H8Z72_05450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z72_05460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z72_05470	COG0328	RNA-DNA hybrid ribonuclease activity
H8Z72_05475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8Z72_05480	COG0631	protein serine/threonine phosphatase activity
H8Z72_05495	COG0859	PFAM glycosyl transferase family 9
H8Z72_05500	COG3642	lipopolysaccharide core region biosynthetic process
H8Z72_05505	COG1234	tRNA 3'-trailer cleavage
H8Z72_05510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H8Z72_05520	COG0315	cyclic pyranopterin monophosphate synthase activity
H8Z72_05525	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H8Z72_05530	COG0314	molybdopterin synthase activity
H8Z72_05610	COG2003	Belongs to the UPF0758 family
H8Z72_05630	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H8Z72_05705	COG0210	DNA helicase
H8Z72_05750	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H8Z72_05755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H8Z72_05760	COG0537	adenosine 5'-monophosphoramidase activity
H8Z72_05780	COG0714	Associated with various cellular activities
H8Z72_05800	COG0424	maF-like protein
H8Z72_05805	COG1399	metal-binding, possibly nucleic acid-binding protein
H8Z72_05810	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H8Z72_05815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z72_05830	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z72_05845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H8Z72_05850	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H8Z72_05875	COG3829	transcription factor binding
H8Z72_05895	COG3609	addiction module antidote protein, CC2985 family
H8Z72_05925	COG2373	Large extracellular alpha-helical protein
H8Z72_05940	COG4953	penicillin-binding protein 1C
H8Z72_05955	COG0019	diaminopimelate decarboxylase activity
H8Z72_05970	COG4264	IucA IucC family
H8Z72_05980	COG4772	TonB-dependent receptor
H8Z72_06005	COG4651	solute:proton antiporter activity
H8Z72_06005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8Z72_06035	COG0488	(ABC) transporter
H8Z72_06075	COG0477	Major facilitator Superfamily
H8Z72_06090	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H8Z72_06105	COG0217	transcriptional regulatory protein
H8Z72_06110	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H8Z72_06115	COG0632	four-way junction helicase activity
H8Z72_06120	COG3158	transport of potassium into the cell
H8Z72_06130	COG2255	four-way junction helicase activity
H8Z72_06135	COG0824	Thioesterase
H8Z72_06145	COG0848	biopolymer transport protein
H8Z72_06155	COG0823	Involved in the tonB-independent uptake of proteins
H8Z72_06160	COG2885	chlorophyll binding
H8Z72_06170	COG0602	queuosine metabolic process
H8Z72_06180	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H8Z72_06185	COG3920	Histidine kinase
H8Z72_06205	COG0840	transmembrane signaling receptor activity
H8Z72_06235	COG0514	ATP-dependent DNA helicase (RecQ)
H8Z72_06240	COG0783	Belongs to the Dps family
H8Z72_06245	COG1643	Atp-dependent helicase
H8Z72_06260	COG0837	glucose binding
H8Z72_06275	COG0535	radical SAM domain protein
H8Z72_06280	COG0535	radical SAM domain protein
H8Z72_06285	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
H8Z72_06290	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H8Z72_06300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8Z72_06310	COG1215	transferase activity, transferring glycosyl groups
H8Z72_06315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8Z72_06325	COG1199	ATP-dependent helicase activity
H8Z72_06335	COG1397	ADP-ribosylglycohydrolase
H8Z72_06345	COG0189	ligase activity
H8Z72_06360	COG0835	chemotaxis
H8Z72_06365	COG0840	transmembrane signaling receptor activity
H8Z72_06370	COG0643	Histidine kinase
H8Z72_06370	COG2198	Histidine kinase
H8Z72_06370	COG0784	Response regulator, receiver
H8Z72_06395	COG1446	asparaginase
H8Z72_06400	COG3142	Participates in the control of copper homeostasis
H8Z72_06435	COG3537	Alpha-1,2-mannosidase
H8Z72_06445	COG1486	melibiose metabolic process
H8Z72_06455	COG0531	amino acid
H8Z72_06470	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z72_06480	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H8Z72_06485	COG3858	chitin binding
H8Z72_06485	COG1388	LysM domain
H8Z72_06500	COG0837	glucose binding
H8Z72_06505	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H8Z72_06515	COG0494	nUDIX hydrolase
H8Z72_06525	COG3956	TIGRFAM MazG family protein
H8Z72_06530	COG1742	UPF0060 membrane protein
H8Z72_06535	COG0330	HflC and HflK could
H8Z72_06545	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H8Z72_06550	COG0509	glycine decarboxylation via glycine cleavage system
H8Z72_06580	COG1960	acyl-CoA dehydrogenase activity
H8Z72_06590	COG1309	transcriptional regulator
H8Z72_06610	COG4771	TonB-dependent receptor
H8Z72_06620	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H8Z72_06625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8Z72_06630	COG0463	Glycosyl transferase, family 2
H8Z72_06635	COG0517	IMP dehydrogenase activity
H8Z72_06635	COG0516	GMP reductase activity
H8Z72_06640	COG2982	Protein involved in outer membrane biogenesis
H8Z72_06645	COG1272	protein, Hemolysin III
H8Z72_06650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H8Z72_06655	COG0739	heme binding
H8Z72_06660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z72_06665	COG0626	cystathionine gamma-synthase activity
H8Z72_06670	COG0460	homoserine dehydrogenase
H8Z72_06670	COG0527	aspartate kinase activity
H8Z72_06680	COG1760	l-serine dehydratase
H8Z72_06700	COG2353	YceI-like domain
H8Z72_06705	COG0784	Response regulator, receiver
H8Z72_06705	COG2198	Histidine kinase
H8Z72_06705	COG2205	protein histidine kinase activity
H8Z72_06725	COG0477	Major facilitator Superfamily
H8Z72_06815	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H8Z72_06825	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H8Z72_06830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H8Z72_06835	COG0259	pyridoxamine-phosphate oxidase activity
H8Z72_06845	COG1842	Phage shock protein A
H8Z72_06870	COG0754	glutathionylspermidine amidase activity
H8Z72_06880	COG2814	Major facilitator Superfamily
H8Z72_06915	COG1234	tRNA 3'-trailer cleavage
H8Z72_06935	COG0531	amino acid
H8Z72_06945	COG2197	response regulator
H8Z72_06965	COG1113	amino acid transport
H8Z72_06975	COG1271	oxidase subunit
H8Z72_06980	COG1294	oxidase, subunit
H8Z72_06995	COG2239	Acts as a magnesium transporter
H8Z72_07000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8Z72_07005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z72_07015	COG1660	Displays ATPase and GTPase activities
H8Z72_07020	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H8Z72_07025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z72_07040	COG1137	ATPase activity
H8Z72_07045	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H8Z72_07055	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H8Z72_07065	COG0271	Belongs to the BolA IbaG family
H8Z72_07070	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H8Z72_07090	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H8Z72_07100	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H8Z72_07110	COG0628	permease
H8Z72_07120	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H8Z72_07125	COG3178	'Phosphotransferase
H8Z72_07135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z72_07140	COG1555	photosystem II stabilization
H8Z72_07155	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8Z72_07160	COG1477	protein flavinylation
H8Z72_07185	COG3128	pkhd-type hydroxylase
H8Z72_07190	COG4774	siderophore transport
H8Z72_07195	COG2146	nitrite reductase [NAD(P)H] activity
H8Z72_07205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H8Z72_07210	COG0719	Fe-S assembly protein
H8Z72_07215	COG0396	ATPase activity
H8Z72_07220	COG0719	Fe-S assembly protein
H8Z72_07225	COG1959	2 iron, 2 sulfur cluster binding
H8Z72_07235	COG0693	protein deglycase activity
H8Z72_07255	COG0739	heme binding
H8Z72_07270	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H8Z72_07285	COG5297	Belongs to the glycosyl hydrolase family 6
H8Z72_07300	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z72_07305	COG1678	Uncharacterized ACR, COG1678
H8Z72_07310	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H8Z72_07315	COG0540	Belongs to the ATCase OTCase family
H8Z72_07320	COG1764	response to oxidative stress
H8Z72_07330	COG0384	phenazine biosynthesis protein PhzF
H8Z72_07335	COG0384	phenazine biosynthesis protein PhzF
H8Z72_07340	COG0527	aspartate kinase activity
H8Z72_07355	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H8Z72_07365	COG0142	geranyltranstransferase activity
H8Z72_07370	COG0629	single-stranded DNA binding
H8Z72_07375	COG5001	Diguanylate cyclase
H8Z72_07375	COG2203	Gaf domain
H8Z72_07375	COG3706	GGDEF domain
H8Z72_07375	COG4251	negative regulation of phosphorylation
H8Z72_07390	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8Z72_07395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H8Z72_07400	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H8Z72_07435	COG2879	small protein
H8Z72_07440	COG1966	Carbon starvation protein
H8Z72_07445	COG1741	Belongs to the pirin family
H8Z72_07460	COG1741	Belongs to the pirin family
H8Z72_07470	COG1515	deoxyribonuclease V activity
H8Z72_07475	COG0588	phosphoglycerate mutase activity
H8Z72_07485	COG3590	peptidase
H8Z72_07490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z72_07495	COG2201	protein-glutamate methylesterase activity
H8Z72_07500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8Z72_07505	COG2199	diguanylate cyclase activity
H8Z72_07505	COG2202	Pas domain
H8Z72_07505	COG2200	EAL domain
H8Z72_07510	COG0835	chemotaxis
H8Z72_07515	COG0840	transmembrane signaling receptor activity
H8Z72_07520	COG2198	Histidine kinase
H8Z72_07520	COG0643	Histidine kinase
H8Z72_07550	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H8Z72_07560	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H8Z72_07565	COG0745	RESPONSE REGULATOR receiver
H8Z72_07570	COG2205	protein histidine kinase activity
H8Z72_07585	COG4452	Inner membrane protein CreD
H8Z72_07610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z72_07615	COG0735	belongs to the Fur family
H8Z72_07630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z72_07640	COG1309	transcriptional regulator
H8Z72_07650	COG2207	Transcriptional regulator
H8Z72_07660	COG0583	DNA-binding transcription factor activity
H8Z72_07665	COG2814	Major facilitator Superfamily
H8Z72_07670	COG0667	Aldo Keto reductase
H8Z72_07740	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H8Z72_07790	COG5001	Diguanylate cyclase
H8Z72_07790	COG5002	protein histidine kinase activity
H8Z72_07795	COG1187	pseudouridine synthase activity
H8Z72_07815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H8Z72_07825	COG0475	glutathione-regulated potassium exporter activity
H8Z72_07830	COG5002	protein histidine kinase activity
H8Z72_07830	COG5000	phosphorelay sensor kinase activity
H8Z72_07835	COG0745	RESPONSE REGULATOR receiver
H8Z72_07840	COG1538	Outer membrane efflux protein
H8Z72_07870	COG1132	(ABC) transporter
H8Z72_07915	COG2155	Conserved Protein
H8Z72_07940	COG3118	belongs to the thioredoxin family
H8Z72_07950	COG0495	leucyl-tRNA aminoacylation
H8Z72_07965	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H8Z72_07980	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H8Z72_07995	COG2968	Membrane
H8Z72_08000	COG0424	maF-like protein
H8Z72_08010	COG3164	Protein of unknown function
H8Z72_08020	COG0312	modulator of DNA gyrase
H8Z72_08025	COG3028	Belongs to the UPF0307 family
H8Z72_08030	COG0312	modulator of DNA gyrase
H8Z72_08040	COG4104	PAAR repeat-containing protein
H8Z72_08045	COG0142	geranyltranstransferase activity
H8Z72_08050	COG1722	exodeoxyribonuclease VII activity
H8Z72_08055	COG0037	tRNA processing
H8Z72_08060	COG1785	Belongs to the alkaline phosphatase family
H8Z72_08065	COG1301	dicarboxylic acid transport
H8Z72_08070	COG4106	trans-aconitate 2-methyltransferase activity
H8Z72_08080	COG0791	NLP P60 protein
H8Z72_08085	COG0791	NLP P60 protein
H8Z72_08090	COG1047	Peptidyl-prolyl cis-trans
H8Z72_08095	COG2311	Membrane
H8Z72_08100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z72_08105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8Z72_08125	COG3590	peptidase
H8Z72_08130	COG3590	peptidase
H8Z72_08150	COG0489	protein tyrosine kinase activity
H8Z72_08155	COG0717	Belongs to the dCTP deaminase family
H8Z72_08180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8Z72_08185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z72_08200	COG0494	nUDIX hydrolase
H8Z72_08205	COG0433	COG0433 Predicted ATPase
H8Z72_08215	COG0688	phosphatidylethanolamine metabolic process
H8Z72_08225	COG2890	protein-(glutamine-N5) methyltransferase activity
H8Z72_08230	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H8Z72_08235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8Z72_08240	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H8Z72_08260	COG0101	tRNA pseudouridine synthase activity
H8Z72_08265	COG0135	phosphoribosylanthranilate isomerase activity
H8Z72_08275	COG0133	tryptophan synthase activity
H8Z72_08285	COG0159	tryptophan synthase activity
H8Z72_08290	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H8Z72_08295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8Z72_08325	COG0300	oxidoreductase activity
H8Z72_08330	COG0149	triose-phosphate isomerase activity
H8Z72_08345	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z72_08350	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z72_08355	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z72_08360	COG0649	NAD binding
H8Z72_08365	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H8Z72_08370	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H8Z72_08380	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H8Z72_08385	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z72_08410	COG1007	ATP synthesis coupled electron transport
H8Z72_08420	COG0779	Required for maturation of 30S ribosomal subunits
H8Z72_08425	COG0195	Participates in both transcription termination and antitermination
H8Z72_08430	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H8Z72_08435	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H8Z72_08440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H8Z72_08445	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H8Z72_08450	COG1185	polyribonucleotide nucleotidyltransferase activity
H8Z72_08485	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8Z72_08495	COG2095	MarC family integral membrane protein
H8Z72_08505	COG1611	Belongs to the LOG family
H8Z72_08510	COG3275	phosphorelay sensor kinase activity
H8Z72_08565	COG3179	chitinase
H8Z72_08610	COG4695	Portal protein
H8Z72_08700	COG0556	nucleotide-excision repair
H8Z72_08715	COG3505	Type IV secretory pathway VirD4
H8Z72_08735	COG2948	multi-organism process
H8Z72_08755	COG3702	type iv secretory pathway
H8Z72_08840	COG1082	Xylose isomerase domain protein TIM barrel
H8Z72_08865	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H8Z72_08870	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H8Z72_08885	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H8Z72_08890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z72_08890	COG0072	phenylalanine-tRNA ligase activity
H8Z72_08940	COG0438	transferase activity, transferring glycosyl groups
H8Z72_08945	COG0438	transferase activity, transferring glycosyl groups
H8Z72_08955	COG0438	transferase activity, transferring glycosyl groups
H8Z72_08980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z72_08985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z72_08990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z72_09010	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H8Z72_09020	COG1960	acyl-CoA dehydrogenase activity
H8Z72_09035	COG3040	lipid binding
H8Z72_09050	COG0322	excinuclease ABC activity
H8Z72_09065	COG4191	Histidine kinase
H8Z72_09065	COG0784	Response regulator, receiver
H8Z72_09070	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H8Z72_09075	COG1194	a g-specific adenine glycosylase
H8Z72_09080	COG0552	protein localization to endoplasmic reticulum
H8Z72_09090	COG3938	Belongs to the proline racemase family
H8Z72_09095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z72_09110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8Z72_09120	COG0006	proline dipeptidase activity
H8Z72_09135	COG0531	amino acid
H8Z72_09210	COG0326	Molecular chaperone. Has ATPase activity
H8Z72_09215	COG0742	ribosomal rna small subunit methyltransferase
H8Z72_09220	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H8Z72_09230	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8Z72_09235	COG0405	Gamma-glutamyltransferase
H8Z72_09240	COG3291	Pkd domain containing protein
H8Z72_09245	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H8Z72_09280	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H8Z72_09285	COG0343	queuine tRNA-ribosyltransferase activity
H8Z72_09290	COG1862	Preprotein translocase
H8Z72_09300	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8Z72_09355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8Z72_09355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8Z72_09360	COG1105	Belongs to the carbohydrate kinase PfkB family
H8Z72_09365	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z72_09365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8Z72_09370	COG1609	Transcriptional regulator
H8Z72_09375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z72_09380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z72_09390	COG2902	Dehydrogenase
H8Z72_09400	COG0477	Major facilitator Superfamily
H8Z72_09410	COG5002	protein histidine kinase activity
H8Z72_09410	COG2205	protein histidine kinase activity
H8Z72_09410	COG0784	Response regulator, receiver
H8Z72_09415	COG2733	membrane
H8Z72_09425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H8Z72_09430	COG2223	nitrite transmembrane transporter activity
H8Z72_09435	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H8Z72_09440	COG0243	molybdopterin cofactor binding
H8Z72_09450	COG0477	Major facilitator Superfamily
H8Z72_09455	COG2703	oxygen carrier activity
H8Z72_09465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z72_09470	COG0174	glutamine synthetase
H8Z72_09475	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H8Z72_09490	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H8Z72_09510	COG3842	ATPase activity
H8Z72_09515	COG1176	ABC-type spermidine putrescine transport system, permease component I
H8Z72_09520	COG1177	transmembrane transport
H8Z72_09525	COG1012	belongs to the aldehyde dehydrogenase family
H8Z72_09540	COG4535	Mg2 and Co2 transporter CorC
H8Z72_09550	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H8Z72_09560	COG1702	phosphate starvation-inducible protein PhoH
H8Z72_09565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8Z72_09580	COG0741	lytic transglycosylase activity
H8Z72_09585	COG0723	plastoquinol--plastocyanin reductase activity
H8Z72_09590	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8Z72_09595	COG2857	Cytochrome c1
H8Z72_09600	COG0625	glutathione transferase activity
H8Z72_09605	COG2969	positive regulation of protein catabolic process
H8Z72_09625	COG1201	RNA secondary structure unwinding
H8Z72_09630	COG2094	Belongs to the DNA glycosylase MPG family
H8Z72_09635	COG0840	transmembrane signaling receptor activity
H8Z72_09640	COG0835	chemotaxis
H8Z72_09840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8Z72_09850	COG1570	exodeoxyribonuclease VII activity
H8Z72_09855	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8Z72_09860	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8Z72_09860	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H8Z72_09865	COG0802	atpase or kinase
H8Z72_09870	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8Z72_09875	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H8Z72_09900	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z72_09905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z72_09910	COG0501	Belongs to the peptidase M48B family
H8Z72_09920	COG2081	HI0933 family
H8Z72_09925	COG4681	YaeQ
H8Z72_09935	COG0625	glutathione transferase activity
H8Z72_09950	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H8Z72_09955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8Z72_09960	COG0513	Belongs to the DEAD box helicase family
H8Z72_09965	COG0488	(ABC) transporter
H8Z72_09980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8Z72_09985	COG0483	inositol monophosphate 1-phosphatase activity
H8Z72_10000	COG3300	MHYT domain
H8Z72_10000	COG5001	Diguanylate cyclase
H8Z72_10005	COG1509	lysine 2,3-aminomutase activity
H8Z72_10010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8Z72_10020	COG0402	S-adenosylhomocysteine deaminase activity
H8Z72_10025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8Z72_10080	COG4302	ethanolamine ammonia-lyase activity
H8Z72_10110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H8Z72_10115	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H8Z72_10130	COG2166	iron-sulfur cluster assembly
H8Z72_10135	COG0215	cysteine-tRNA ligase activity
H8Z72_10145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H8Z72_10150	COG0137	argininosuccinate synthase activity
H8Z72_10160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z72_10165	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H8Z72_10175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H8Z72_10180	COG0165	Argininosuccinate lyase
H8Z72_10190	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H8Z72_10200	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H8Z72_10225	COG1294	oxidase, subunit
H8Z72_10245	COG4988	ABC transporter
H8Z72_10250	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H8Z72_10255	COG1278	Cold shock
H8Z72_10260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z72_10280	COG1138	Cytochrome C-type biogenesis protein
H8Z72_10285	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H8Z72_10305	COG4133	protoheme IX ABC transporter activity
H8Z72_10310	COG0436	Aminotransferase
H8Z72_10330	COG1187	pseudouridine synthase activity
H8Z72_10335	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H8Z72_10340	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H8Z72_10345	COG2350	Protein conserved in bacteria
H8Z72_10375	COG1175	transmembrane transport
H8Z72_10380	COG0395	ABC-type sugar transport system, permease component
H8Z72_10405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8Z72_10410	COG2957	Belongs to the agmatine deiminase family
H8Z72_10425	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H8Z72_10430	COG0539	negative regulation of cytoplasmic translation
H8Z72_10435	COG0776	regulation of translation
H8Z72_10445	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H8Z72_10450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8Z72_10460	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H8Z72_10465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8Z72_10465	COG0475	glutathione-regulated potassium exporter activity
H8Z72_10475	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H8Z72_10485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8Z72_10485	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z72_10490	COG0582	viral genome integration into host DNA
H8Z72_10525	COG2003	Belongs to the UPF0758 family
H8Z72_10545	COG2084	Dehydrogenase
H8Z72_10685	COG0270	DNA (cytosine-5-)-methyltransferase activity
H8Z72_10740	COG2274	protein secretion by the type I secretion system
H8Z72_10760	COG2273	Hydrolase Family 16
H8Z72_10760	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
H8Z72_10780	COG4206	TonB-dependent receptor
H8Z72_10805	COG2336	PFAM SpoVT AbrB
H8Z72_10825	COG2801	Transposase and inactivated derivatives
H8Z72_10835	COG4774	siderophore transport
H8Z72_10850	COG0582	viral genome integration into host DNA
H8Z72_10880	COG2003	Belongs to the UPF0758 family
H8Z72_10890	COG5489	Protein of unknown function (DUF736)
H8Z72_10895	COG1396	sequence-specific DNA binding
H8Z72_10900	COG2801	Transposase and inactivated derivatives
H8Z72_10905	COG3002	Belongs to the UPF0753 family
H8Z72_10910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8Z72_10915	COG0583	DNA-binding transcription factor activity
H8Z72_10935	COG2197	response regulator
H8Z72_10955	COG1335	isochorismatase
H8Z72_10970	COG2814	Major facilitator Superfamily
H8Z72_10985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8Z72_10985	COG1648	precorrin-2 dehydrogenase activity
H8Z72_11010	COG3685	Protein conserved in bacteria
H8Z72_11030	COG5001	Diguanylate cyclase
H8Z72_11040	COG4566	intracellular signal transduction
H8Z72_11080	COG3279	Response regulator of the LytR AlgR family
H8Z72_11115	COG1238	metal cluster binding
H8Z72_11145	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z72_11155	COG2226	methyltransferase
H8Z72_11155	COG1073	alpha beta
H8Z72_11200	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H8Z72_11200	COG0316	Belongs to the HesB IscA family
H8Z72_11205	COG2154	pterin-4-alpha-carbinolamine dehydratase
H8Z72_11215	COG0428	transporter
H8Z72_11220	COG3064	Membrane
H8Z72_11230	COG1530	ribonuclease E activity
H8Z72_11240	COG1054	Belongs to the UPF0176 family
H8Z72_11260	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H8Z72_11270	COG0582	viral genome integration into host DNA
H8Z72_11285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z72_11290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z72_11425	COG0629	single-stranded DNA binding
H8Z72_11430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z72_11435	COG0270	DNA (cytosine-5-)-methyltransferase activity
H8Z72_11610	COG2003	Belongs to the UPF0758 family
H8Z72_11710	COG2801	Transposase and inactivated derivatives
H8Z72_11715	COG0582	viral genome integration into host DNA
H8Z72_11725	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8Z72_11730	COG0322	excinuclease ABC activity
H8Z72_11740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8Z72_11745	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H8Z72_11750	COG1663	tetraacyldisaccharide 4'-kinase activity
H8Z72_11755	COG1132	(ABC) transporter
H8Z72_11765	COG0811	peptide transport
H8Z72_11780	COG1136	(ABC) transporter
H8Z72_11785	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8Z72_11795	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H8Z72_11800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H8Z72_11815	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H8Z72_11840	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8Z72_11845	COG0837	glucose binding
H8Z72_11850	COG0363	glucosamine-6-phosphate deaminase activity
H8Z72_11855	COG0129	dihydroxy-acid dehydratase activity
H8Z72_11860	COG0800	Aldolase
H8Z72_11930	COG0784	Response regulator, receiver
H8Z72_11930	COG2205	protein histidine kinase activity
H8Z72_11940	COG2183	response to ionizing radiation
H8Z72_11950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z72_11950	COG0723	plastoquinol--plastocyanin reductase activity
H8Z72_11965	COG3243	poly(R)-hydroxyalkanoic acid synthase
H8Z72_11975	COG1183	phosphatidylcholine synthase activity
H8Z72_11980	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z72_11995	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H8Z72_12005	COG0668	transmembrane transport
H8Z72_12010	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H8Z72_12025	COG1914	H( )-stimulated, divalent metal cation uptake system
H8Z72_12040	COG0746	molybdenum cofactor guanylyltransferase activity
H8Z72_12045	COG0303	'Molybdopterin
H8Z72_12055	COG0708	Exodeoxyribonuclease III
H8Z72_12090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H8Z72_12095	COG0303	'Molybdopterin
H8Z72_12100	COG1160	GTP binding
H8Z72_12105	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z72_12115	COG1426	Protein conserved in bacteria
H8Z72_12125	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H8Z72_12140	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8Z72_12140	COG1024	Enoyl-CoA hydratase
H8Z72_12145	COG0183	Belongs to the thiolase family
H8Z72_12150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8Z72_12155	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H8Z72_12165	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H8Z72_12175	COG1674	ftsk spoiiie
H8Z72_12180	COG0492	ferredoxin-NADP+ reductase activity
H8Z72_12190	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H8Z72_12200	COG0542	response to heat
H8Z72_12215	COG0482	sulfurtransferase activity
H8Z72_12220	COG2915	High frequency lysogenization protein hflD homolog
H8Z72_12250	COG5002	protein histidine kinase activity
H8Z72_12270	COG0784	Response regulator, receiver
H8Z72_12270	COG0835	chemotaxis
H8Z72_12280	COG1558	bacterial-type flagellum-dependent cell motility
H8Z72_12285	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H8Z72_12295	COG4787	bacterial-type flagellum-dependent cell motility
H8Z72_12310	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H8Z72_12315	COG1706	bacterial-type flagellum-dependent cell motility
H8Z72_12320	COG1705	Flagellar rod assembly protein muramidase FlgJ
H8Z72_12320	COG3951	Flagellar rod assembly protein muramidase FlgJ
H8Z72_12330	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8Z72_12335	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8Z72_12345	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H8Z72_12375	COG2201	protein-glutamate methylesterase activity
H8Z72_12395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z72_12400	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z72_12405	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z72_12435	COG1677	Flagellar hook-basal body complex protein FliE
H8Z72_12485	COG3190	flagellar
H8Z72_12500	COG1684	flagellar biosynthetic protein fliR
H8Z72_12525	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8Z72_12555	COG0643	Histidine kinase
H8Z72_12555	COG2198	Histidine kinase
H8Z72_12555	COG0784	Response regulator, receiver
H8Z72_12565	COG0641	radical SAM
H8Z72_12605	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H8Z72_12610	COG1360	Flagellar Motor Protein
H8Z72_12620	COG0835	chemotaxis
H8Z72_12630	COG0745	RESPONSE REGULATOR receiver
H8Z72_12635	COG0643	Histidine kinase
H8Z72_12635	COG2198	Histidine kinase
H8Z72_12660	COG0840	transmembrane signaling receptor activity
H8Z72_12670	COG0840	transmembrane signaling receptor activity
H8Z72_12675	COG0840	transmembrane signaling receptor activity
H8Z72_12680	COG0840	transmembrane signaling receptor activity
H8Z72_12685	COG0840	transmembrane signaling receptor activity
H8Z72_12690	COG0840	transmembrane signaling receptor activity
H8Z72_12705	COG0840	transmembrane signaling receptor activity
H8Z72_12710	COG0840	transmembrane signaling receptor activity
H8Z72_12720	COG0835	chemotaxis
H8Z72_12730	COG0840	transmembrane signaling receptor activity
H8Z72_12740	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H8Z72_12745	COG2201	protein-glutamate methylesterase activity
H8Z72_12755	COG2267	carboxylic ester hydrolase activity
H8Z72_12790	COG1024	Enoyl-CoA hydratase
H8Z72_12795	COG2205	protein histidine kinase activity
H8Z72_12795	COG2198	Histidine kinase
H8Z72_12795	COG0784	Response regulator, receiver
H8Z72_12805	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8Z72_12815	COG3279	Response regulator of the LytR AlgR family
H8Z72_12855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H8Z72_12865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z72_12870	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H8Z72_12880	COG0505	Belongs to the CarA family
H8Z72_12885	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H8Z72_12890	COG2258	MOSC domain
H8Z72_12895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8Z72_12940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8Z72_12960	COG0277	FAD linked oxidase domain protein
H8Z72_12965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8Z72_12975	COG0531	amino acid
H8Z72_12980	COG0531	amino acid
H8Z72_12985	COG0235	Class ii aldolase
H8Z72_12990	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H8Z72_12995	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H8Z72_13010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H8Z72_13010	COG0140	phosphoribosyl-ATP diphosphatase activity
H8Z72_13015	COG0107	imidazoleglycerol-phosphate synthase activity
H8Z72_13020	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H8Z72_13025	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H8Z72_13030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H8Z72_13030	COG0131	Imidazoleglycerol-phosphate dehydratase
H8Z72_13035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z72_13040	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H8Z72_13045	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H8Z72_13055	COG0124	histidyl-tRNA synthetase
H8Z72_13060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z72_13130	COG3210	domain, Protein
H8Z72_13145	COG1649	PFAM Uncharacterised BCR, COG1649
H8Z72_13145	COG0726	polysaccharide deacetylase
H8Z72_13150	COG1215	transferase activity, transferring glycosyl groups
H8Z72_13165	COG1012	belongs to the aldehyde dehydrogenase family
H8Z72_13180	COG0167	dihydroorotate dehydrogenase activity
H8Z72_13185	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H8Z72_13190	COG0697	spore germination
H8Z72_13195	COG1794	racemase activity, acting on amino acids and derivatives
H8Z72_13210	COG0671	phosphoesterase, PA-phosphatase related
H8Z72_13215	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H8Z72_13225	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H8Z72_13230	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z72_13235	COG2203	Gaf domain
H8Z72_13235	COG3706	GGDEF domain
H8Z72_13235	COG4251	negative regulation of phosphorylation
H8Z72_13235	COG5001	Diguanylate cyclase
H8Z72_13245	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z72_13265	COG0166	Belongs to the GPI family
H8Z72_13270	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H8Z72_13275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H8Z72_13280	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H8Z72_13300	COG1469	GTP cyclohydrolase I activity
H8Z72_13305	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8Z72_13325	COG0477	Major facilitator Superfamily
H8Z72_13330	COG2115	Belongs to the xylose isomerase family
H8Z72_13335	COG1070	Carbohydrate kinase
H8Z72_13345	COG1501	Belongs to the glycosyl hydrolase 31 family
H8Z72_13380	COG0800	Aldolase
H8Z72_13385	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z72_13395	COG3734	2-keto-3-deoxy-galactonokinase
H8Z72_13400	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H8Z72_13410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8Z72_13425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8Z72_13430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H8Z72_13445	COG0351	phosphomethylpyrimidine kinase
H8Z72_13445	COG0352	thiamine-phosphate diphosphorylase activity
H8Z72_13470	COG0583	DNA-binding transcription factor activity
H8Z72_13475	COG1741	Belongs to the pirin family
H8Z72_13490	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H8Z72_13495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H8Z72_13500	COG2137	regulation of response to DNA damage stimulus
H8Z72_13505	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H8Z72_13510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8Z72_13520	COG1546	Belongs to the CinA family
H8Z72_13525	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H8Z72_13535	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8Z72_13540	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8Z72_13550	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H8Z72_13555	COG1534	Rna-binding protein
H8Z72_13570	COG1238	metal cluster binding
H8Z72_13575	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H8Z72_13580	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H8Z72_13585	COG2840	Smr protein MutS2
H8Z72_13590	COG0585	pseudouridine synthase activity
H8Z72_13595	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H8Z72_13600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H8Z72_13605	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H8Z72_13610	COG0148	phosphopyruvate hydratase activity
H8Z72_13620	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H8Z72_13625	COG0504	CTP synthase activity
H8Z72_13650	COG0306	phosphate transporter
H8Z72_13660	COG1253	flavin adenine dinucleotide binding
H8Z72_13675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z72_13680	COG0477	Major facilitator Superfamily
H8Z72_13690	COG1136	(ABC) transporter
H8Z72_13705	COG0438	transferase activity, transferring glycosyl groups
H8Z72_13715	COG2264	protein methyltransferase activity
H8Z72_13745	COG2244	polysaccharide biosynthetic process
H8Z72_13795	COG1595	DNA-templated transcription, initiation
H8Z72_13810	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8Z72_13820	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H8Z72_13830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z72_13845	COG0784	Response regulator, receiver
H8Z72_13845	COG4191	Histidine kinase
H8Z72_13850	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H8Z72_13880	COG0840	transmembrane signaling receptor activity
H8Z72_13945	COG0583	DNA-binding transcription factor activity
H8Z72_13950	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8Z72_13955	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H8Z72_13970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H8Z72_13975	COG0077	Prephenate dehydratase
H8Z72_13975	COG1605	Chorismate mutase
H8Z72_13980	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H8Z72_13985	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H8Z72_13990	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H8Z72_14035	COG1228	amidohydrolase
H8Z72_14040	COG2986	histidine ammonia-lyase
H8Z72_14050	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H8Z72_14060	COG4993	Dehydrogenase
H8Z72_14070	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H8Z72_14085	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H8Z72_14090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8Z72_14095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z72_14105	COG3115	cell septum assembly
H8Z72_14115	COG0359	binds to the 23S rRNA
H8Z72_14120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H8Z72_14125	COG0360	Binds together with S18 to 16S ribosomal RNA
H8Z72_14130	COG0316	Belongs to the HesB IscA family
H8Z72_14135	COG0017	Asparaginyl-tRNA synthetase
H8Z72_14155	COG2808	Putative FMN-binding domain
H8Z72_14180	COG3002	Belongs to the UPF0753 family
H8Z72_14230	COG0288	reversible hydration of carbon dioxide
H8Z72_14235	COG0662	Cupin 2, conserved barrel domain protein
H8Z72_14245	COG3844	kynureninase activity
H8Z72_14250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z72_14260	COG2925	Exonuclease
H8Z72_14285	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8Z72_14290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H8Z72_14290	COG0116	Belongs to the methyltransferase superfamily
H8Z72_14300	COG0488	(ABC) transporter
H8Z72_14335	COG0494	nUDIX hydrolase
H8Z72_14345	COG1024	Enoyl-CoA hydratase
H8Z72_14355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H8Z72_14360	COG0659	secondary active sulfate transmembrane transporter activity
H8Z72_14385	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8Z72_14390	COG0573	inorganic phosphate transmembrane transporter activity
H8Z72_14395	COG0581	inorganic phosphate transmembrane transporter activity
H8Z72_14400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8Z72_14405	COG0704	Plays a role in the regulation of phosphate uptake
H8Z72_14415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8Z72_14425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8Z72_14435	COG0557	exoribonuclease II activity
H8Z72_14450	COG1960	acyl-CoA dehydrogenase activity
H8Z72_14455	COG1960	acyl-CoA dehydrogenase activity
H8Z72_14460	COG1960	acyl-CoA dehydrogenase activity
H8Z72_14465	COG1960	acyl-CoA dehydrogenase activity
H8Z72_14470	COG2226	methyltransferase
H8Z72_14475	COG1410	methionine synthase
H8Z72_14475	COG0646	methionine synthase
H8Z72_14480	COG0646	methionine synthase
H8Z72_14480	COG1410	methionine synthase
H8Z72_14490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z72_14515	COG2900	Belongs to the SlyX family
H8Z72_14530	COG0386	Belongs to the glutathione peroxidase family
H8Z72_14540	COG1725	Transcriptional regulator
H8Z72_14545	COG1131	(ABC) transporter
H8Z72_14575	COG1253	flavin adenine dinucleotide binding
H8Z72_14595	COG2850	peptidyl-arginine hydroxylation
H8Z72_14630	COG1132	(ABC) transporter
H8Z72_14635	COG0583	DNA-binding transcription factor activity
H8Z72_14665	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H8Z72_14675	COG0484	heat shock protein binding
H8Z72_14680	COG0443	Heat shock 70 kDa protein
H8Z72_14685	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H8Z72_14690	COG1420	regulation of RNA biosynthetic process
H8Z72_14695	COG0497	DNA recombination
H8Z72_14705	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z72_14720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H8Z72_14745	COG3706	GGDEF domain
H8Z72_14775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z72_14790	COG0583	DNA-binding transcription factor activity
H8Z72_14800	COG0415	Belongs to the DNA photolyase family
H8Z72_14805	COG0305	Participates in initiation and elongation during chromosome replication
H8Z72_14815	COG0367	asparagine synthase
H8Z72_14830	COG1960	acyl-CoA dehydrogenase activity
H8Z72_14845	COG0084	hydrolase, TatD family'
H8Z72_14850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H8Z72_14905	COG0386	Belongs to the glutathione peroxidase family
H8Z72_14910	COG0339	signal peptide processing
H8Z72_14960	COG2814	Major facilitator Superfamily
H8Z72_14965	COG1566	PFAM secretion protein HlyD family protein
H8Z72_14995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8Z72_15010	COG4774	siderophore transport
H8Z72_15020	COG0367	asparagine synthase
H8Z72_15025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z72_15030	COG1393	Belongs to the ArsC family
H8Z72_15040	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H8Z72_15080	COG0052	Belongs to the universal ribosomal protein uS2 family
H8Z72_15085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H8Z72_15095	COG0528	UMP kinase activity
H8Z72_15100	COG0233	cytoplasmic translational termination
H8Z72_15105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H8Z72_15110	COG0575	Belongs to the CDS family
H8Z72_15115	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H8Z72_15120	COG0750	zinc metalloprotease
H8Z72_15135	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z72_15140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z72_15145	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z72_15150	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z72_15155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H8Z72_15165	COG0825	malonyl-CoA metabolic process
H8Z72_15180	COG1981	membrane
H8Z72_15200	COG1695	Transcriptional regulator
H8Z72_15220	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8Z72_15230	COG2040	homocysteine
H8Z72_15235	COG0833	amino acid
H8Z72_15240	COG0346	lactoylglutathione lyase activity
H8Z72_15245	COG1131	(ABC) transporter
H8Z72_15260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z72_15260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z72_15270	COG2878	Part of a membrane complex involved in electron transport
H8Z72_15285	COG1595	DNA-templated transcription, initiation
H8Z72_15310	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H8Z72_15325	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H8Z72_15330	COG0251	oxidation-reduction process
H8Z72_15340	COG0392	lysyltransferase activity
H8Z72_15340	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H8Z72_15375	COG2814	Major facilitator Superfamily
H8Z72_15380	COG1902	pentaerythritol trinitrate reductase activity
H8Z72_15385	COG2824	Alkylphosphonate utilization operon protein PhnA
H8Z72_15390	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H8Z72_15395	COG1047	Peptidyl-prolyl cis-trans
H8Z72_15400	COG1077	Cell shape determining protein MreB Mrl
H8Z72_15415	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H8Z72_15425	COG5487	UPF0391 membrane protein
H8Z72_15430	COG1451	nucleotide metabolic process
H8Z72_15455	COG0183	Belongs to the thiolase family
H8Z72_15485	COG1793	dna ligase
H8Z72_15485	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8Z72_15495	COG1793	dna ligase
H8Z72_15500	COG1201	RNA secondary structure unwinding
H8Z72_15510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z72_15515	COG1278	Cold shock
H8Z72_15520	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H8Z72_15525	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H8Z72_15530	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z72_15535	COG3046	protein related to deoxyribodipyrimidine photolyase
H8Z72_15540	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
H8Z72_15545	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H8Z72_15550	COG2954	triphosphatase activity
H8Z72_15555	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8Z72_15565	COG1381	Involved in DNA repair and RecF pathway recombination
H8Z72_15570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H8Z72_15575	COG0571	ribonuclease III activity
H8Z72_15590	COG0481	GTPase activity
H8Z72_15595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8Z72_15610	COG1024	Enoyl-CoA hydratase
H8Z72_15610	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8Z72_15630	COG1024	Enoyl-CoA hydratase
H8Z72_15635	COG1960	acyl-CoA dehydrogenase activity
H8Z72_15655	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H8Z72_15660	COG3250	beta-galactosidase activity
H8Z72_15680	COG3209	COG3209 Rhs family protein
H8Z72_15690	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H8Z72_15700	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H8Z72_15720	COG0534	Mate efflux family protein
H8Z72_15725	COG0335	large ribosomal subunit rRNA binding
H8Z72_15730	COG0336	Belongs to the RNA methyltransferase TrmD family
H8Z72_15735	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H8Z72_15740	COG0228	four-way junction DNA binding
H8Z72_15745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8Z72_15755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H8Z72_15760	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8Z72_15790	COG0784	Response regulator, receiver
H8Z72_15790	COG4191	Histidine kinase
H8Z72_15795	COG3850	Histidine kinase
H8Z72_15795	COG2205	protein histidine kinase activity
H8Z72_15795	COG3437	response regulator, receiver
H8Z72_15795	COG4999	Histidine kinase
H8Z72_15800	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8Z72_15810	COG2205	protein histidine kinase activity
H8Z72_15815	COG5507	3-demethylubiquinone-9 3-methyltransferase
H8Z72_15825	COG4771	TonB-dependent receptor
H8Z72_15850	COG2172	sigma factor antagonist activity
H8Z72_15855	COG1366	Belongs to the anti-sigma-factor antagonist family
H8Z72_15860	COG1366	Belongs to the anti-sigma-factor antagonist family
H8Z72_15875	COG2207	Transcriptional regulator
H8Z72_15885	COG3152	Membrane
H8Z72_15900	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H8Z72_15905	COG1845	cytochrome c oxidase, subunit III
H8Z72_15910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H8Z72_15925	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H8Z72_15930	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H8Z72_15935	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H8Z72_15940	COG0196	riboflavin kinase activity
H8Z72_15950	COG0268	Binds directly to 16S ribosomal RNA
H8Z72_15955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H8Z72_15960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H8Z72_15965	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H8Z72_15970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H8Z72_15975	COG0824	Thioesterase
H8Z72_15990	COG1946	Acyl-CoA thioesterase
H8Z72_16010	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H8Z72_16020	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H8Z72_16045	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H8Z72_16060	COG2197	response regulator
H8Z72_16065	COG4585	Histidine kinase
H8Z72_16075	COG0850	regulation of cytokinetic process
H8Z72_16080	COG2894	cell division
H8Z72_16085	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H8Z72_16095	COG0642	Histidine kinase
H8Z72_16100	COG0745	RESPONSE REGULATOR receiver
H8Z72_16115	COG2194	sulfuric ester hydrolase activity
H8Z72_16130	COG2814	Major facilitator Superfamily
H8Z72_16135	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8Z72_16135	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8Z72_16145	COG0656	L-ascorbic acid biosynthetic process
H8Z72_16150	COG0753	catalase activity
H8Z72_16165	COG2207	Transcriptional regulator
H8Z72_16165	COG1917	Cupin 2, conserved barrel domain protein
H8Z72_16180	COG1506	peptidase
H8Z72_16180	COG0823	Involved in the tonB-independent uptake of proteins
H8Z72_16195	COG1297	OPT oligopeptide transporter protein
H8Z72_16215	COG0587	DNA-directed DNA polymerase activity
H8Z72_16230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8Z72_16265	COG2080	2 iron, 2 sulfur cluster binding
H8Z72_16270	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8Z72_16275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H8Z72_16300	COG0492	ferredoxin-NADP+ reductase activity
H8Z72_16320	COG3537	Alpha-1,2-mannosidase
H8Z72_16325	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z72_16330	COG3387	PFAM Glycoside hydrolase 15-related
H8Z72_16340	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8Z72_16415	COG1309	transcriptional regulator
H8Z72_16420	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z72_16425	COG0308	aminopeptidase N
H8Z72_16430	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H8Z72_16440	COG0330	HflC and HflK could
H8Z72_16445	COG0330	HflC and HflK could
H8Z72_16465	COG0678	peroxiredoxin activity
H8Z72_16500	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H8Z72_16510	COG1492	cobalamin metabolic process
H8Z72_16520	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8Z72_16540	COG4206	TonB-dependent receptor
H8Z72_16545	COG0542	response to heat
H8Z72_16550	COG1116	anion transmembrane transporter activity
H8Z72_16555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z72_16560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H8Z72_16565	COG0667	Aldo Keto reductase
H8Z72_16570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z72_16575	COG4771	TonB-dependent receptor
H8Z72_16580	COG2827	Endonuclease containing a URI domain
H8Z72_16620	COG1877	trehalose-phosphatase activity
H8Z72_16625	COG3387	PFAM Glycoside hydrolase 15-related
H8Z72_16640	COG0840	transmembrane signaling receptor activity
H8Z72_16645	COG3011	Protein conserved in bacteria
H8Z72_16660	COG0564	pseudouridine synthase activity
H8Z72_16665	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z72_16675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8Z72_16675	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H8Z72_16695	COG2951	lytic endotransglycosylase activity
H8Z72_16700	COG4644	lycopene metabolic process
H8Z72_16725	COG2369	cell adhesion
H8Z72_16750	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H8Z72_16755	COG0045	succinate-CoA ligase (ADP-forming) activity
H8Z72_16770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z72_16800	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H8Z72_16805	COG0237	dephospho-CoA kinase activity
H8Z72_16840	COG5002	protein histidine kinase activity
H8Z72_16845	COG0745	RESPONSE REGULATOR receiver
H8Z72_16990	COG2022	thiamine diphosphate biosynthetic process
H8Z72_16995	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H8Z72_17000	COG0471	metal ion transport
H8Z72_17000	COG3273	potassium ion transport
H8Z72_17020	COG1970	mechanosensitive ion channel activity
H8Z72_17040	COG3250	beta-galactosidase activity
H8Z72_17045	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z72_17060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8Z72_17070	COG0308	aminopeptidase N
H8Z72_17105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z72_17120	COG0529	Catalyzes the synthesis of activated sulfate
H8Z72_17120	COG2895	sulfate adenylyltransferase (ATP) activity
H8Z72_17125	COG0175	sulfate reduction
H8Z72_17130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8Z72_17135	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8Z72_17140	COG0175	sulfate reduction
H8Z72_17160	COG2205	protein histidine kinase activity
H8Z72_17160	COG2198	Histidine kinase
H8Z72_17160	COG0784	Response regulator, receiver
H8Z72_17175	COG1648	precorrin-2 dehydrogenase activity
H8Z72_17175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8Z72_17190	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H8Z72_17195	COG3588	fructose-bisphosphate aldolase
H8Z72_17200	COG0469	pyruvate kinase activity
H8Z72_17210	COG0126	phosphoglycerate kinase activity
H8Z72_17230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8Z72_17240	COG3047	cAMP biosynthetic process
H8Z72_17245	COG3047	cAMP biosynthetic process
H8Z72_17255	COG3453	Protein conserved in bacteria
H8Z72_17255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z72_17260	COG0725	ABC transporter, periplasmic molybdate-binding protein
H8Z72_17265	COG4149	molybdate abc transporter
H8Z72_17270	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H8Z72_17305	COG1376	ErfK ybiS ycfS ynhG family protein
H8Z72_17310	COG0739	heme binding
H8Z72_17320	COG4773	Receptor
H8Z72_17325	COG0596	Alpha beta hydrolase
H8Z72_17330	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H8Z72_17335	COG1301	dicarboxylic acid transport
H8Z72_17345	COG2304	oxidoreductase activity
H8Z72_17365	COG0714	Associated with various cellular activities
H8Z72_17395	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H8Z72_17420	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8Z72_17430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8Z72_17440	COG0194	GDP metabolic process
H8Z72_17445	COG1561	YicC-like family, N-terminal region
H8Z72_17450	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H8Z72_17460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8Z72_17465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8Z72_17480	COG0006	proline dipeptidase activity
H8Z72_17490	COG0006	proline dipeptidase activity
H8Z72_17495	COG3079	Belongs to the UPF0149 family
H8Z72_17515	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H8Z72_17525	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H8Z72_17535	COG2912	Transglutaminase-like superfamily
H8Z72_17540	COG1773	rubredoxin
H8Z72_17545	COG0352	thiamine-phosphate diphosphorylase activity
H8Z72_17560	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8Z72_17575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z72_17605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8Z72_17610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z72_17620	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z72_17630	COG0671	phosphoesterase, PA-phosphatase related
H8Z72_17635	COG3781	membrane
H8Z72_17645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8Z72_17650	COG0563	adenylate kinase activity
H8Z72_17665	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H8Z72_17675	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H8Z72_17695	COG3710	Transcriptional regulator
H8Z72_17700	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H8Z72_17710	COG0840	transmembrane signaling receptor activity
H8Z72_17715	COG0405	Gamma-glutamyltransferase
H8Z72_17720	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H8Z72_17740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H8Z72_17745	COG0473	3-isopropylmalate dehydrogenase activity
H8Z72_17750	COG0066	3-isopropylmalate dehydratase activity
H8Z72_17755	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H8Z72_17775	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H8Z72_17780	COG1538	Outer membrane efflux protein
H8Z72_17785	COG1519	Transferase
H8Z72_17790	COG1560	Kdo2-lipid A biosynthetic process
H8Z72_17815	COG0280	phosphate acetyltransferase
H8Z72_17815	COG0281	malic enzyme
H8Z72_17820	COG1301	dicarboxylic acid transport
H8Z72_17845	COG0583	DNA-binding transcription factor activity
H8Z72_17850	COG0667	Aldo Keto reductase
H8Z72_17865	COG2197	response regulator
H8Z72_17875	COG0642	Histidine kinase
H8Z72_17890	COG2851	Citrate transporter
H8Z72_17895	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z72_17900	COG1609	Transcriptional regulator
H8Z72_17905	COG2211	Major facilitator Superfamily
H8Z72_17930	COG1162	GTPase activity
H8Z72_17950	COG4773	Receptor
H8Z72_17955	COG0726	polysaccharide deacetylase
H8Z72_17960	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8Z72_17990	COG1307	EDD domain protein, DegV family
H8Z72_17995	COG0242	peptide deformylase activity
H8Z72_18015	COG0457	Tetratricopeptide repeat
H8Z72_18020	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H8Z72_18025	COG1215	transferase activity, transferring glycosyl groups
H8Z72_18030	COG1215	transferase activity, transferring glycosyl groups
H8Z72_18045	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H8Z72_18090	COG2188	Transcriptional regulator
H8Z72_18105	COG1450	Type ii and iii secretion system protein
H8Z72_18120	COG3166	PFAM Fimbrial assembly family protein
H8Z72_18125	COG3156	type II secretion system protein K
H8Z72_18130	COG4795	General secretion pathway protein
H8Z72_18135	COG2165	general secretion pathway protein
H8Z72_18140	COG4970	Tfp pilus assembly protein FimT
H8Z72_18145	COG2165	general secretion pathway protein
H8Z72_18150	COG1459	type II secretion system
H8Z72_18155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z72_18160	COG1404	Belongs to the peptidase S8 family
H8Z72_18165	COG5295	Hep Hag repeat protein
H8Z72_18170	COG1404	Belongs to the peptidase S8 family
H8Z72_18175	COG5295	Hep Hag repeat protein
H8Z72_18180	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H8Z72_18180	COG0047	phosphoribosylformylglycinamidine synthase activity
H8Z72_18185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8Z72_18190	COG4974	Belongs to the 'phage' integrase family
H8Z72_18205	COG0795	lipopolysaccharide-transporting ATPase activity
H8Z72_18215	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8Z72_18230	COG0525	valine-tRNA ligase activity
H8Z72_18265	COG1183	phosphatidylcholine synthase activity
H8Z72_18275	COG0442	prolyl-tRNA aminoacylation
H8Z72_18290	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8Z72_18295	COG1127	ABC transporter
H8Z72_18300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8Z72_18300	COG3218	ABC-type transport auxiliary lipoprotein component
H8Z72_18335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8Z72_18340	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H8Z72_18340	COG0662	Cupin 2, conserved barrel domain protein
H8Z72_18370	COG2086	electron transfer activity
H8Z72_18385	COG0546	phosphoglycolate phosphatase activity
H8Z72_18385	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8Z72_18390	COG0277	FAD linked oxidase domain protein
H8Z72_18395	COG0300	oxidoreductase activity
H8Z72_18405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z72_18425	COG2226	methyltransferase
H8Z72_18435	COG3754	Rhamnan synthesis protein F
H8Z72_18440	COG0438	transferase activity, transferring glycosyl groups
H8Z72_18440	COG1216	Glycosyl transferase, family 2
H8Z72_18445	COG0110	maltose O-acetyltransferase activity
H8Z72_18460	COG0626	cystathionine gamma-synthase activity
H8Z72_18490	COG0625	glutathione transferase activity
H8Z72_18500	COG0513	Belongs to the DEAD box helicase family
H8Z72_18510	COG4206	TonB-dependent receptor
H8Z72_18515	COG0720	synthase
H8Z72_18525	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H8Z72_18530	COG1956	GAF domain-containing protein
H8Z72_18540	COG2819	hydrolase of the alpha beta superfamily
H8Z72_18555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8Z72_18560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z72_18575	COG0339	signal peptide processing
H8Z72_18630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8Z72_18635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z72_18640	COG1136	(ABC) transporter
H8Z72_18640	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8Z72_18645	COG0577	efflux transmembrane transporter activity
H8Z72_18650	COG0577	efflux transmembrane transporter activity
H8Z72_18665	COG4191	Histidine kinase
H8Z72_18670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8Z72_18685	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H8Z72_18690	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H8Z72_18695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H8Z72_18700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H8Z72_18705	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H8Z72_18710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8Z72_18720	COG0356	it plays a direct role in the translocation of protons across the membrane
H8Z72_18740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8Z72_18750	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8Z72_18790	COG2011	ABC-type metal ion transport system permease component
H8Z72_18795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H8Z72_18800	COG0697	spore germination
H8Z72_18805	COG1666	GTP binding
H8Z72_18815	COG5002	protein histidine kinase activity
H8Z72_18815	COG2198	Histidine kinase
H8Z72_18815	COG0784	Response regulator, receiver
H8Z72_18835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8Z72_18840	COG1187	pseudouridine synthase activity
H8Z72_18845	COG2813	Specifically methylates the guanine in position
H8Z72_18865	COG2202	Pas domain
H8Z72_18865	COG2205	protein histidine kinase activity
H8Z72_18885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8Z72_18890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z72_18945	COG0842	Transport permease protein
H8Z72_18950	COG1131	(ABC) transporter
H8Z72_18955	COG0025	NhaP-type Na H and K H
H8Z72_18960	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H8Z72_18965	COG1573	uracil-dna glycosylase
H8Z72_18975	COG3384	dioxygenase
H8Z72_18985	COG0583	DNA-binding transcription factor activity
H8Z72_18995	COG0667	Aldo Keto reductase
H8Z72_19005	COG3590	peptidase
H8Z72_19025	COG0531	amino acid
H8Z72_19040	COG2972	Histidine kinase
H8Z72_19055	COG3685	Protein conserved in bacteria
H8Z72_19060	COG3546	catalase activity
H8Z72_19105	COG1271	oxidase subunit
H8Z72_19110	COG1294	oxidase, subunit
H8Z72_19125	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z72_19130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8Z72_19150	COG1132	(ABC) transporter
H8Z72_19165	COG1063	alcohol dehydrogenase
H8Z72_19240	COG0251	oxidation-reduction process
H8Z72_19255	COG0840	transmembrane signaling receptor activity
H8Z72_19270	COG0583	DNA-binding transcription factor activity
H8Z72_19275	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8Z72_19320	COG0024	Methionine aminopeptidase
H8Z72_19360	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8Z72_19390	COG4695	Portal protein
H8Z72_19435	COG3179	chitinase
H8Z72_19625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8Z72_19630	COG1490	D-aminoacyl-tRNA deacylase activity
H8Z72_19635	COG1560	Kdo2-lipid A biosynthetic process
H8Z72_19685	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H8Z72_19685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8Z72_19690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H8Z72_19695	COG0242	peptide deformylase activity
H8Z72_19700	COG1652	LysM domain
H8Z72_19705	COG0758	DNA mediated transformation
H8Z72_19725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z72_19725	COG1754	DNA topoisomerase type I activity
H8Z72_19730	COG0009	L-threonylcarbamoyladenylate synthase
H8Z72_19745	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z72_19755	COG0616	signal peptide processing
H8Z72_19760	COG0534	Mate efflux family protein
H8Z72_19780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H8Z72_19785	COG0625	glutathione transferase activity
H8Z72_19800	COG1252	NADH dehydrogenase
H8Z72_19805	COG2860	membrane
H8Z72_19810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8Z72_19815	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H8Z72_19820	COG2201	protein-glutamate methylesterase activity
H8Z72_19825	COG2177	Part of the ABC transporter FtsEX involved in
H8Z72_19830	COG2884	Cell division ATP-binding protein ftsE
H8Z72_19835	COG0513	Belongs to the DEAD box helicase family
H8Z72_19840	COG3118	belongs to the thioredoxin family
H8Z72_19845	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H8Z72_19850	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H8Z72_19855	COG0583	DNA-binding transcription factor activity
H8Z72_19900	COG1518	maintenance of DNA repeat elements
H8Z72_19905	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H8Z72_19915	COG1652	LysM domain
H8Z72_19920	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8Z72_19920	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8Z72_19925	COG1473	amidohydrolase
H8Z72_19930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z72_19935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z72_19945	COG5383	Protein conserved in bacteria
H8Z72_19985	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H8Z72_19990	COG3023	N-Acetylmuramoyl-L-alanine amidase
H8Z72_20000	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z72_20010	COG0531	amino acid
H8Z72_20025	COG4682	membrane
H8Z72_20030	COG2133	pyrroloquinoline quinone binding
H8Z72_20040	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H8Z72_20045	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H8Z72_20055	COG1610	YqeY-like protein
H8Z72_20060	COG1295	ribonuclease BN
H8Z72_20065	COG0358	DNA primase activity
H8Z72_20080	COG0109	protoheme IX farnesyltransferase activity
H8Z72_20110	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H8Z72_20125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H8Z72_20165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H8Z72_20170	COG0739	heme binding
H8Z72_20175	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H8Z72_20185	COG2223	nitrite transmembrane transporter activity
H8Z72_20190	COG0708	Exodeoxyribonuclease III
H8Z72_20195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8Z72_20205	COG1192	Involved in chromosome partitioning
H8Z72_20210	COG1475	DNA binding
H8Z72_20225	COG0463	Glycosyl transferase, family 2
H8Z72_20245	COG0756	dUTP diphosphatase activity
H8Z72_20250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H8Z72_20255	COG2003	Belongs to the UPF0758 family
H8Z72_20260	COG0018	arginyl-trna synthetase
H8Z72_20275	COG4221	oxidoreductase activity
H8Z72_20280	COG2755	lipolytic protein G-D-S-L family
H8Z72_20280	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H8Z72_20290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z72_20295	COG1166	arginine decarboxylase activity
H8Z72_20300	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H8Z72_20335	COG0606	chelatase, subunit chli
H8Z72_20350	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H8Z72_20375	COG1690	Belongs to the RtcB family
H8Z72_20415	COG1090	epimerase
H8Z72_20425	COG0642	Histidine kinase
H8Z72_20450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8Z72_20475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8Z72_20480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8Z72_20495	COG0753	catalase activity
H8Z72_20510	COG2197	response regulator
H8Z72_20515	COG4585	Histidine kinase
H8Z72_20520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z72_20525	COG1136	(ABC) transporter
H8Z72_20550	COG0697	spore germination
H8Z72_20565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z72_20570	COG0180	Tryptophanyl-tRNA synthetase
H8Z72_20575	COG3237	CsbD-like
H8Z72_20615	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H8Z72_20630	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H8Z72_20675	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8Z72_20695	COG1199	ATP-dependent helicase activity
H8Z72_20710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8Z72_20775	COG0625	glutathione transferase activity
H8Z72_20810	COG4555	ABC transporter
H8Z72_20820	COG1476	TRANSCRIPTIONal
H8Z72_20865	COG0543	2 iron, 2 sulfur cluster binding
H8Z72_20865	COG0633	Ferredoxin
H8Z72_20870	COG1131	(ABC) transporter
H8Z72_20875	COG0842	Transport permease protein
H8Z72_20885	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H8Z72_20920	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8Z72_20925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8Z72_20935	COG0045	succinate-CoA ligase (ADP-forming) activity
H8Z72_20935	COG1042	CoA-binding domain protein
H8Z72_20935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8Z72_20940	COG2239	Acts as a magnesium transporter
H8Z72_20955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8Z72_20960	COG3387	PFAM Glycoside hydrolase 15-related
H8Z72_20975	COG3100	YcgL domain-containing protein
H8Z72_20980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8Z72_20990	COG0463	Glycosyl transferase, family 2
H8Z72_21010	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z72_21045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z72_21060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8Z72_21085	COG1506	peptidase
H8Z72_21085	COG4946	Tricorn protease homolog
H8Z72_21085	COG0823	Involved in the tonB-independent uptake of proteins
H8Z72_21100	COG0408	coproporphyrinogen oxidase activity
H8Z72_21135	COG0515	serine threonine protein kinase
H8Z72_21135	COG2815	serine threonine protein kinase
H8Z72_21140	COG0631	protein serine/threonine phosphatase activity
H8Z72_21320	COG0210	DNA helicase
H8Z72_21330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z72_21335	COG0583	DNA-binding transcription factor activity
H8Z72_21340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H8Z72_21350	COG2159	amidohydrolase
H8Z72_21370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z72_21390	COG0357	Ribosomal RNA small subunit methyltransferase G
H8Z72_21395	COG3540	Alkaline phosphatase
H8Z72_21405	COG2091	lysine biosynthetic process via aminoadipic acid
H8Z72_21420	COG0708	Exodeoxyribonuclease III
H8Z72_21425	COG1940	carbohydrate kinase activity
H8Z72_21425	COG1846	Transcriptional regulator
H8Z72_21435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z72_21445	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8Z72_21450	COG3162	membrane
H8Z72_21460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8Z72_21485	COG3507	Belongs to the glycosyl hydrolase 43 family
H8Z72_21505	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z72_21510	COG0179	Fumarylacetoacetate (FAA) hydrolase
H8Z72_21515	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z72_21520	COG3254	rhamnose metabolic process
H8Z72_21525	COG0738	Major facilitator superfamily
H8Z72_21530	COG1414	Transcriptional regulator
H8Z72_21535	COG1971	Probably functions as a manganese efflux pump
H8Z72_21540	COG2205	protein histidine kinase activity
H8Z72_21550	COG3459	Glycosyltransferase 36 associated
H8Z72_21555	COG2211	Major facilitator Superfamily
H8Z72_21560	COG3265	gluconokinase activity
H8Z72_21565	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z72_21585	COG2911	Protein conserved in bacteria
H8Z72_21590	COG0729	surface antigen
H8Z72_21615	COG0752	glycyl-tRNA synthetase alpha subunit
H8Z72_21620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z72_21630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8Z72_21630	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z72_21640	COG0805	protein transport
H8Z72_21645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8Z72_21650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8Z72_21660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8Z72_21680	COG2974	May be involved in recombination
H8Z72_21685	COG0037	tRNA processing
H8Z72_21690	COG2115	Belongs to the xylose isomerase family
H8Z72_21700	COG3661	Belongs to the glycosyl hydrolase 67 family
H8Z72_21710	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z72_21720	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z72_21725	COG0246	Mannitol dehydrogenase
H8Z72_21770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8Z72_21800	COG3386	PFAM SMP-30 Gluconolaconase
H8Z72_21810	COG3250	beta-galactosidase activity
H8Z72_21815	COG1904	glucuronate isomerase
H8Z72_21835	COG3693	PFAM glycoside hydrolase, family 10
H8Z72_21850	COG2211	Major facilitator Superfamily
H8Z72_21930	COG2937	Belongs to the GPAT DAPAT family
H8Z72_21960	COG0284	orotidine-5'-phosphate decarboxylase activity
H8Z72_21965	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H8Z72_21970	COG3132	Protein of unknown function, DUF480
H8Z72_21985	COG0210	DNA helicase
H8Z72_21990	COG1435	thymidine kinase activity
H8Z72_22000	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H8Z72_22010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H8Z72_22040	COG3135	benzoate transporter
H8Z72_22060	COG0676	glucose-6-phosphate 1-epimerase activity
H8Z72_22070	COG3012	SEC-C Motif Domain Protein
H8Z72_22075	COG0730	response to heat
H8Z72_22100	COG0302	gtp cyclohydrolase
H8Z72_22115	COG1566	PFAM secretion protein HlyD family protein
H8Z72_22125	COG1289	transmembrane transporter activity
H8Z72_22130	COG0477	Major facilitator Superfamily
H8Z72_22140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z72_22160	COG4691	Plasmid stability protein
H8Z72_22165	COG1487	ribonuclease activity
H8Z72_22200	COG0564	pseudouridine synthase activity
H8Z72_22255	COG1074	ATP-dependent DNA helicase activity
H8Z72_22260	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H8Z72_22275	COG1127	ABC transporter
H8Z72_22280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8Z72_22285	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8Z72_22300	COG2853	Lipoprotein
H8Z72_22310	COG0386	Belongs to the glutathione peroxidase family
H8Z72_22320	COG1322	Protein conserved in bacteria
H8Z72_22325	COG0604	alcohol dehydrogenase
H8Z72_22340	COG0625	glutathione transferase activity
H8Z72_22350	COG0531	amino acid
H8Z72_22355	COG3537	Alpha-1,2-mannosidase
H8Z72_22365	COG3706	GGDEF domain
H8Z72_22370	COG3835	regulator
H8Z72_22375	COG1929	Belongs to the glycerate kinase type-1 family
H8Z72_22380	COG2271	Major facilitator Superfamily
H8Z72_22395	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H8Z72_22400	COG0861	Integral membrane protein TerC family
H8Z72_22410	COG0584	glycerophosphoryl diester phosphodiesterase
H8Z72_22425	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H8Z72_22430	COG0726	polysaccharide deacetylase
H8Z72_22435	COG0706	membrane insertase activity
H8Z72_22440	COG0594	ribonuclease P activity
H8Z72_22470	COG0741	lytic transglycosylase activity
H8Z72_22515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8Z72_22615	COG3550	peptidyl-serine autophosphorylation
H8Z72_22785	COG1192	Involved in chromosome partitioning
H8Z72_22975	COG1063	alcohol dehydrogenase
H8Z72_22985	COG2217	Heavy metal translocating P-type atpase
H8Z72_22990	COG2217	Heavy metal translocating P-type atpase
H8Z72_23005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z72_23010	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z72_23035	COG2871	sodium ion transport
H8Z72_23055	COG2188	Transcriptional regulator
H8Z72_23060	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H8Z72_23065	COG2986	histidine ammonia-lyase
H8Z72_23070	COG0010	Belongs to the arginase family
H8Z72_23105	COG2132	Multicopper oxidase
H8Z72_23130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8Z72_23180	COG4644	lycopene metabolic process
H8Z72_23405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8Z72_23440	COG0629	single-stranded DNA binding
H8Z72_23480	COG1475	DNA binding
H8Z72_23665	COG4456	Virulence-associated protein
H8Z72_23670	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z72_23690	COG3318	Belongs to the UPF0149 family
H8Z72_23690	COG3012	SEC-C Motif Domain Protein
H8Z72_23710	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z72_23905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z72_23945	COG3012	SEC-C Motif Domain Protein
H8Z72_23945	COG3318	Belongs to the UPF0149 family
H8Z72_23965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z72_23985	COG3451	type IV secretory pathway VirB4
H8Z72_23995	COG3838	Conjugal transfer protein Trbc
H8Z72_24000	COG4962	Type ii secretion system protein e
H8Z72_24065	COG0489	protein tyrosine kinase activity
H8Z72_24105	COG4680	protein conserved in bacteria
H8Z72_24195	COG1192	Involved in chromosome partitioning
H8Z72_24250	COG3318	Belongs to the UPF0149 family
H8Z72_24250	COG3012	SEC-C Motif Domain Protein
H8Z72_24270	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z72_24305	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z72_24345	COG3505	Type IV secretory pathway VirD4
H8Z72_24360	COG1487	ribonuclease activity
H8Z72_24370	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z72_24390	COG3012	SEC-C Motif Domain Protein
H8Z72_24390	COG3318	Belongs to the UPF0149 family