locus-tag	class	description
H8Z74_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H8Z74_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8Z74_00020	COG0187	DNA topoisomerase II activity
H8Z74_00030	COG0501	Belongs to the peptidase M48B family
H8Z74_00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H8Z74_00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z74_00115	COG0793	Belongs to the peptidase S41A family
H8Z74_00120	COG4942	peptidase
H8Z74_00130	COG2234	aminopeptidase activity
H8Z74_00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z74_00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z74_00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z74_00165	COG1064	alcohol dehydrogenase
H8Z74_00175	COG0493	'glutamate synthase
H8Z74_00180	COG0067	glutamate synthase
H8Z74_00180	COG0069	glutamate synthase activity
H8Z74_00180	COG0070	glutamate synthase
H8Z74_00230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8Z74_00245	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H8Z74_00250	COG0297	glycogen (starch) synthase activity
H8Z74_00250	COG0438	transferase activity, transferring glycosyl groups
H8Z74_00270	COG0367	asparagine synthase
H8Z74_00300	COG1132	(ABC) transporter
H8Z74_00335	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H8Z74_00420	COG1111	helicase
H8Z74_00420	COG1205	dead DEAH box helicase
H8Z74_00425	COG1272	protein, Hemolysin III
H8Z74_00445	COG0300	oxidoreductase activity
H8Z74_00450	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z74_00470	COG2249	NAD(P)H dehydrogenase (quinone) activity
H8Z74_00525	COG3237	CsbD-like
H8Z74_00570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z74_00575	COG0477	Major facilitator Superfamily
H8Z74_00615	COG0714	Associated with various cellular activities
H8Z74_00645	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H8Z74_00655	COG4772	TonB-dependent receptor
H8Z74_00665	COG0662	Cupin 2, conserved barrel domain protein
H8Z74_00670	COG1012	belongs to the aldehyde dehydrogenase family
H8Z74_00695	COG1304	FMN binding
H8Z74_00705	COG4585	Histidine kinase
H8Z74_00710	COG2197	response regulator
H8Z74_00730	COG3710	Transcriptional regulator
H8Z74_00735	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H8Z74_00805	COG0366	Alpha amylase catalytic
H8Z74_00810	COG0366	Alpha amylase catalytic
H8Z74_00815	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z74_00835	COG0657	acetylesterase activity
H8Z74_00835	COG2755	lipolytic protein G-D-S-L family
H8Z74_00845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H8Z74_00860	COG3507	Belongs to the glycosyl hydrolase 43 family
H8Z74_00865	COG1609	Transcriptional regulator
H8Z74_00870	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H8Z74_00875	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z74_00885	COG2755	lipolytic protein G-D-S-L family
H8Z74_00900	COG3186	Phenylalanine-4-hydroxylase
H8Z74_00905	COG1522	sequence-specific DNA binding
H8Z74_00915	COG1752	Esterase of the alpha-beta hydrolase superfamily
H8Z74_00925	COG1119	ATPase activity
H8Z74_00940	COG1125	glycine betaine transport
H8Z74_00955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8Z74_00975	COG1396	sequence-specific DNA binding
H8Z74_00995	COG0489	protein tyrosine kinase activity
H8Z74_01000	COG2062	phosphohistidine phosphatase, SixA
H8Z74_01010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z74_01055	COG1968	undecaprenyl-diphosphatase activity
H8Z74_01060	COG0174	glutamine synthetase
H8Z74_01065	COG0347	Belongs to the P(II) protein family
H8Z74_01070	COG0004	ammonium transporteR
H8Z74_01075	COG3852	Histidine kinase
H8Z74_01080	COG2204	response regulator
H8Z74_01085	COG2032	superoxide dismutase activity
H8Z74_01090	COG2032	superoxide dismutase activity
H8Z74_01100	COG0346	lactoylglutathione lyase activity
H8Z74_01110	COG0183	Belongs to the thiolase family
H8Z74_01150	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H8Z74_01155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H8Z74_01170	COG0028	Belongs to the TPP enzyme family
H8Z74_01175	COG2205	protein histidine kinase activity
H8Z74_01200	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H8Z74_01215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z74_01225	COG0596	Alpha beta hydrolase
H8Z74_01230	COG0727	PFAM Uncharacterised protein family (UPF0153)
H8Z74_01235	COG0318	PFAM AMP-dependent synthetase and ligase
H8Z74_01240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z74_01250	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8Z74_01260	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8Z74_01295	COG0339	signal peptide processing
H8Z74_01325	COG0475	glutathione-regulated potassium exporter activity
H8Z74_01330	COG0583	DNA-binding transcription factor activity
H8Z74_01335	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H8Z74_01340	COG2224	Isocitrate lyase
H8Z74_01375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H8Z74_01380	COG1960	acyl-CoA dehydrogenase activity
H8Z74_01435	COG0523	cobalamin synthesis protein
H8Z74_01445	COG0697	spore germination
H8Z74_01455	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H8Z74_01460	COG1846	Transcriptional regulator
H8Z74_01465	COG1764	response to oxidative stress
H8Z74_01490	COG2130	NADP-dependent
H8Z74_01505	COG1187	pseudouridine synthase activity
H8Z74_01525	COG4807	Protein conserved in bacteria
H8Z74_01530	COG2351	hydroxyisourate hydrolase activity
H8Z74_01535	COG2072	flavoprotein involved in K transport
H8Z74_01555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H8Z74_01590	COG1957	nucleoside hydrolase
H8Z74_01600	COG2252	PERMEase
H8Z74_01620	COG0084	hydrolase, TatD family'
H8Z74_01635	COG0583	DNA-binding transcription factor activity
H8Z74_01640	COG2814	Major facilitator Superfamily
H8Z74_01655	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H8Z74_01660	COG1902	pentaerythritol trinitrate reductase activity
H8Z74_01680	COG0745	RESPONSE REGULATOR receiver
H8Z74_01685	COG2205	protein histidine kinase activity
H8Z74_01690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z74_01710	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H8Z74_01715	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8Z74_01720	COG0583	DNA-binding transcription factor activity
H8Z74_01750	COG0702	epimerase
H8Z74_01755	COG1733	regulation of RNA biosynthetic process
H8Z74_01785	COG0129	dihydroxy-acid dehydratase activity
H8Z74_01800	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H8Z74_01860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H8Z74_01865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H8Z74_01890	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H8Z74_01895	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H8Z74_01905	COG3485	protocatechuate 3,4-dioxygenase
H8Z74_01910	COG3485	protocatechuate 3,4-dioxygenase
H8Z74_01920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z74_01925	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H8Z74_01935	COG1414	Transcriptional regulator
H8Z74_01945	COG0657	acetylesterase activity
H8Z74_01955	COG0445	tRNA wobble uridine modification
H8Z74_01965	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H8Z74_01995	COG2267	carboxylic ester hydrolase activity
H8Z74_02005	COG0156	8-amino-7-oxononanoate synthase activity
H8Z74_02010	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H8Z74_02015	COG1040	competence protein
H8Z74_02020	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8Z74_02100	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8Z74_02170	COG1511	domain protein
H8Z74_02170	COG3264	Mechanosensitive ion channel
H8Z74_02175	COG1368	sulfuric ester hydrolase activity
H8Z74_02180	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8Z74_02185	COG2354	Protein conserved in bacteria
H8Z74_02195	COG0297	glycogen (starch) synthase activity
H8Z74_02200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z74_02230	COG0702	epimerase
H8Z74_02235	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z74_02265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z74_02270	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z74_02280	COG0513	Belongs to the DEAD box helicase family
H8Z74_02305	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H8Z74_02315	COG3483	tryptophan 2,3-dioxygenase activity
H8Z74_02320	COG3104	oligopeptide transport
H8Z74_02345	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H8Z74_02360	COG1320	monovalent cation:proton antiporter activity
H8Z74_02365	COG2212	antiporter activity
H8Z74_02375	COG0651	ATP synthesis coupled electron transport
H8Z74_02380	COG1006	Multisubunit Na H antiporter MnhC subunit
H8Z74_02385	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8Z74_02385	COG2111	Na H antiporter
H8Z74_02405	COG3179	chitinase
H8Z74_02425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H8Z74_02430	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H8Z74_02445	COG0456	acetyltransferase
H8Z74_02450	COG1597	lipid kinase activity
H8Z74_02475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8Z74_02480	COG0134	indole-3-glycerol-phosphate synthase activity
H8Z74_02490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z74_02495	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H8Z74_02505	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H8Z74_02515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H8Z74_02530	COG1051	belongs to the nudix hydrolase family
H8Z74_02570	COG0316	Belongs to the HesB IscA family
H8Z74_02585	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8Z74_02605	COG2814	Major facilitator Superfamily
H8Z74_02610	COG0583	DNA-binding transcription factor activity
H8Z74_02615	COG2814	Major facilitator Superfamily
H8Z74_02620	COG1289	transmembrane transporter activity
H8Z74_02630	COG0151	Belongs to the GarS family
H8Z74_02640	COG0138	bifunctional purine biosynthesis protein purh
H8Z74_02645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8Z74_02650	COG2267	carboxylic ester hydrolase activity
H8Z74_02655	COG2453	phosphatase
H8Z74_02655	COG0671	phosphoesterase, PA-phosphatase related
H8Z74_02680	COG4589	Belongs to the CDS family
H8Z74_02685	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H8Z74_02720	COG0439	Biotin carboxylase
H8Z74_02730	COG0511	ligase activity, forming carbon-carbon bonds
H8Z74_02735	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H8Z74_02745	COG1324	tolerance protein
H8Z74_02770	COG0300	oxidoreductase activity
H8Z74_02775	COG2356	endonuclease I
H8Z74_02790	COG0459	protein refolding
H8Z74_02805	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H8Z74_02820	COG3386	PFAM SMP-30 Gluconolaconase
H8Z74_02830	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H8Z74_02835	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8Z74_02850	COG0778	Nitroreductase
H8Z74_02855	COG2353	YceI-like domain
H8Z74_02885	COG3052	prosthetic group binding
H8Z74_02910	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8Z74_02920	COG1802	Transcriptional regulator
H8Z74_02975	COG4221	oxidoreductase activity
H8Z74_02990	COG4221	oxidoreductase activity
H8Z74_03000	COG0435	Glutathione S-transferase
H8Z74_03025	COG2409	Drug exporters of the RND superfamily
H8Z74_03030	COG0823	Involved in the tonB-independent uptake of proteins
H8Z74_03030	COG1506	peptidase
H8Z74_03070	COG0697	spore germination
H8Z74_03085	COG1113	amino acid transport
H8Z74_03105	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H8Z74_03140	COG5001	Diguanylate cyclase
H8Z74_03145	COG0840	transmembrane signaling receptor activity
H8Z74_03150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z74_03150	COG5297	Belongs to the glycosyl hydrolase family 6
H8Z74_03155	COG0659	secondary active sulfate transmembrane transporter activity
H8Z74_03170	COG2943	transferase activity, transferring hexosyl groups
H8Z74_03180	COG3275	phosphorelay sensor kinase activity
H8Z74_03190	COG0181	hydroxymethylbilane synthase activity
H8Z74_03220	COG0436	Aminotransferase
H8Z74_03230	COG2832	Protein of unknown function (DUF454)
H8Z74_03240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H8Z74_03250	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H8Z74_03255	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H8Z74_03260	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H8Z74_03285	COG2226	methyltransferase
H8Z74_03290	COG5001	Diguanylate cyclase
H8Z74_03290	COG3300	MHYT domain
H8Z74_03295	COG0308	aminopeptidase N
H8Z74_03340	COG3284	Transcriptional regulator
H8Z74_03345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z74_03350	COG1077	Cell shape determining protein MreB Mrl
H8Z74_03355	COG1792	Involved in formation and maintenance of cell shape
H8Z74_03370	COG0772	Belongs to the SEDS family
H8Z74_03380	COG2951	lytic endotransglycosylase activity
H8Z74_03385	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H8Z74_03390	COG1686	Belongs to the peptidase S11 family
H8Z74_03400	COG2921	Belongs to the UPF0250 family
H8Z74_03405	COG0321	lipoyl(octanoyl) transferase activity
H8Z74_03410	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8Z74_03425	COG0583	DNA-binding transcription factor activity
H8Z74_03435	COG1051	belongs to the nudix hydrolase family
H8Z74_03435	COG1056	cytidyltransferase-related domain
H8Z74_03470	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H8Z74_03475	COG0673	inositol 2-dehydrogenase activity
H8Z74_03480	COG2823	Periplasmic or secreted lipoprotein
H8Z74_03485	COG4251	negative regulation of phosphorylation
H8Z74_03490	COG0784	Response regulator, receiver
H8Z74_03495	COG4191	Histidine kinase
H8Z74_03500	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H8Z74_03555	COG1459	type II secretion system
H8Z74_03605	COG3250	beta-galactosidase activity
H8Z74_03620	COG2188	Transcriptional regulator
H8Z74_03630	COG1609	Transcriptional regulator
H8Z74_03635	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8Z74_03640	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H8Z74_03650	COG0617	tRNA 3'-terminal CCA addition
H8Z74_03655	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H8Z74_03660	COG1012	belongs to the aldehyde dehydrogenase family
H8Z74_03665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H8Z74_03695	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H8Z74_03700	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8Z74_03745	COG3791	Glutathione-dependent formaldehyde-activating
H8Z74_03760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8Z74_03770	COG0697	spore germination
H8Z74_03780	COG0488	(ABC) transporter
H8Z74_03790	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H8Z74_03795	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H8Z74_03805	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8Z74_03805	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8Z74_03825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H8Z74_03830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8Z74_03835	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H8Z74_03855	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H8Z74_03865	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H8Z74_03870	COG2205	protein histidine kinase activity
H8Z74_03875	COG0745	RESPONSE REGULATOR receiver
H8Z74_03890	COG0277	FAD linked oxidase domain protein
H8Z74_03895	COG1988	membrane-bound metal-dependent
H8Z74_03900	COG0792	nuclease activity
H8Z74_03935	COG0275	rRNA processing
H8Z74_03940	COG3116	cell division
H8Z74_03950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8Z74_03955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H8Z74_03960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8Z74_03970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8Z74_03975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8Z74_03980	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8Z74_03985	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H8Z74_04000	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H8Z74_04010	COG0739	heme binding
H8Z74_04015	COG0653	protein targeting
H8Z74_04020	COG0494	nUDIX hydrolase
H8Z74_04030	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H8Z74_04040	COG3321	synthase
H8Z74_04040	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z74_04040	COG0604	alcohol dehydrogenase
H8Z74_04055	COG0366	Alpha amylase catalytic
H8Z74_04085	COG2226	methyltransferase
H8Z74_04090	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H8Z74_04100	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H8Z74_04140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H8Z74_04150	COG4106	trans-aconitate 2-methyltransferase activity
H8Z74_04155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8Z74_04165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z74_04170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8Z74_04175	COG0667	Aldo Keto reductase
H8Z74_04185	COG4771	TonB-dependent receptor
H8Z74_04205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z74_04210	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H8Z74_04220	COG2175	clavaminate synthase activity
H8Z74_04230	COG4181	ATPase activity
H8Z74_04255	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H8Z74_04275	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H8Z74_04280	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H8Z74_04295	COG3829	transcription factor binding
H8Z74_04305	COG1116	anion transmembrane transporter activity
H8Z74_04310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z74_04320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z74_04325	COG0431	NADPH-dependent FMN reductase
H8Z74_04350	COG0747	negative chemotaxis
H8Z74_04360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H8Z74_04370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H8Z74_04375	COG2967	ApaG domain
H8Z74_04380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H8Z74_04385	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H8Z74_04390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z74_04395	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H8Z74_04430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z74_04435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z74_04465	COG3384	dioxygenase
H8Z74_04470	COG0583	DNA-binding transcription factor activity
H8Z74_04485	COG1024	Enoyl-CoA hydratase
H8Z74_04505	COG3386	PFAM SMP-30 Gluconolaconase
H8Z74_04520	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H8Z74_04545	COG0697	spore germination
H8Z74_04550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z74_04570	COG5002	protein histidine kinase activity
H8Z74_04570	COG2205	protein histidine kinase activity
H8Z74_04570	COG0784	Response regulator, receiver
H8Z74_04575	COG2197	response regulator
H8Z74_04585	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8Z74_04595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8Z74_04600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z74_04605	COG0583	DNA-binding transcription factor activity
H8Z74_04610	COG3634	alkyl hydroperoxide reductase activity
H8Z74_04620	COG2890	protein-(glutamine-N5) methyltransferase activity
H8Z74_04640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8Z74_04640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8Z74_04670	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H8Z74_04695	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H8Z74_04710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8Z74_04715	COG1404	Belongs to the peptidase S8 family
H8Z74_04720	COG1404	Belongs to the peptidase S8 family
H8Z74_04725	COG1404	Belongs to the peptidase S8 family
H8Z74_04730	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H8Z74_04755	COG1295	ribonuclease BN
H8Z74_04760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z74_04765	COG1254	Belongs to the acylphosphatase family
H8Z74_04780	COG0521	Mo-molybdopterin cofactor biosynthetic process
H8Z74_04790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H8Z74_04795	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H8Z74_04805	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H8Z74_04810	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H8Z74_04820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H8Z74_04825	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H8Z74_04830	COG0193	aminoacyl-tRNA hydrolase activity
H8Z74_04835	COG0012	GTP binding
H8Z74_04855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8Z74_04870	COG0250	Participates in transcription elongation, termination and antitermination
H8Z74_04875	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H8Z74_04880	COG0081	regulation of translation
H8Z74_04885	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H8Z74_04890	COG0222	ribosome binding
H8Z74_04895	COG0085	RNA polymerase activity
H8Z74_04900	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8Z74_04905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H8Z74_04910	COG0049	tRNA binding
H8Z74_04915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H8Z74_04920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8Z74_04925	COG0051	transcription antitermination factor activity, RNA binding
H8Z74_04930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H8Z74_04935	COG0088	Forms part of the polypeptide exit tunnel
H8Z74_04940	COG0089	rRNA binding
H8Z74_04945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H8Z74_04950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H8Z74_04960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H8Z74_04965	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H8Z74_04970	COG0255	Belongs to the universal ribosomal protein uL29 family
H8Z74_04975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H8Z74_04985	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H8Z74_04990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H8Z74_05000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H8Z74_05005	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H8Z74_05010	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H8Z74_05020	COG1841	ribosomal large subunit assembly
H8Z74_05025	COG0200	Binds to the 23S rRNA
H8Z74_05030	COG0201	protein transport
H8Z74_05055	COG0203	ribosomal protein L17
H8Z74_05060	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H8Z74_05075	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H8Z74_05085	COG0154	amidase activity
H8Z74_05095	COG1217	gtp-binding protein TYPA
H8Z74_05100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8Z74_05105	COG0039	L-malate dehydrogenase activity
H8Z74_05110	COG0625	glutathione transferase activity
H8Z74_05120	COG0446	pyridine nucleotide-disulphide oxidoreductase
H8Z74_05120	COG1902	pentaerythritol trinitrate reductase activity
H8Z74_05125	COG0604	alcohol dehydrogenase
H8Z74_05150	COG0156	8-amino-7-oxononanoate synthase activity
H8Z74_05155	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H8Z74_05160	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H8Z74_05165	COG4208	sulfate ABC transporter
H8Z74_05170	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H8Z74_05180	COG1063	alcohol dehydrogenase
H8Z74_05215	COG0406	alpha-ribazole phosphatase activity
H8Z74_05220	COG0285	dihydrofolate synthase activity
H8Z74_05240	COG2833	Protein of unknown function (DUF455)
H8Z74_05250	COG3291	Pkd domain containing protein
H8Z74_05260	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z74_05265	COG0671	phosphoesterase, PA-phosphatase related
H8Z74_05270	COG0438	transferase activity, transferring glycosyl groups
H8Z74_05280	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H8Z74_05295	COG4783	chaperone-mediated protein folding
H8Z74_05310	COG0473	3-isopropylmalate dehydrogenase activity
H8Z74_05425	COG0544	peptidyl-prolyl cis-trans isomerase activity
H8Z74_05435	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H8Z74_05465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z74_05475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z74_05485	COG0328	RNA-DNA hybrid ribonuclease activity
H8Z74_05490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8Z74_05495	COG0631	protein serine/threonine phosphatase activity
H8Z74_05510	COG0859	PFAM glycosyl transferase family 9
H8Z74_05515	COG3642	lipopolysaccharide core region biosynthetic process
H8Z74_05520	COG1234	tRNA 3'-trailer cleavage
H8Z74_05525	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H8Z74_05535	COG0315	cyclic pyranopterin monophosphate synthase activity
H8Z74_05540	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H8Z74_05545	COG0314	molybdopterin synthase activity
H8Z74_05625	COG2003	Belongs to the UPF0758 family
H8Z74_05645	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H8Z74_05715	COG0210	DNA helicase
H8Z74_05760	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H8Z74_05765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H8Z74_05770	COG0537	adenosine 5'-monophosphoramidase activity
H8Z74_05790	COG0714	Associated with various cellular activities
H8Z74_05810	COG0424	maF-like protein
H8Z74_05815	COG1399	metal-binding, possibly nucleic acid-binding protein
H8Z74_05820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H8Z74_05825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z74_05840	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z74_05855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H8Z74_05860	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H8Z74_05885	COG3829	transcription factor binding
H8Z74_05905	COG3609	addiction module antidote protein, CC2985 family
H8Z74_05935	COG2373	Large extracellular alpha-helical protein
H8Z74_05950	COG4953	penicillin-binding protein 1C
H8Z74_05970	COG0678	peroxiredoxin activity
H8Z74_05990	COG0330	HflC and HflK could
H8Z74_05995	COG0330	HflC and HflK could
H8Z74_06005	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H8Z74_06010	COG0308	aminopeptidase N
H8Z74_06015	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z74_06020	COG1309	transcriptional regulator
H8Z74_06095	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8Z74_06105	COG3387	PFAM Glycoside hydrolase 15-related
H8Z74_06110	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z74_06115	COG3537	Alpha-1,2-mannosidase
H8Z74_06135	COG0492	ferredoxin-NADP+ reductase activity
H8Z74_06160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H8Z74_06165	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8Z74_06170	COG2080	2 iron, 2 sulfur cluster binding
H8Z74_06205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8Z74_06220	COG0587	DNA-directed DNA polymerase activity
H8Z74_06240	COG1297	OPT oligopeptide transporter protein
H8Z74_06255	COG0823	Involved in the tonB-independent uptake of proteins
H8Z74_06255	COG1506	peptidase
H8Z74_06270	COG1917	Cupin 2, conserved barrel domain protein
H8Z74_06270	COG2207	Transcriptional regulator
H8Z74_06285	COG0753	catalase activity
H8Z74_06290	COG0656	L-ascorbic acid biosynthetic process
H8Z74_06300	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8Z74_06300	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8Z74_06305	COG2814	Major facilitator Superfamily
H8Z74_06320	COG2194	sulfuric ester hydrolase activity
H8Z74_06335	COG0745	RESPONSE REGULATOR receiver
H8Z74_06340	COG0642	Histidine kinase
H8Z74_06350	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H8Z74_06355	COG2894	cell division
H8Z74_06360	COG0850	regulation of cytokinetic process
H8Z74_06370	COG4585	Histidine kinase
H8Z74_06375	COG2197	response regulator
H8Z74_06390	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H8Z74_06415	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H8Z74_06425	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H8Z74_06445	COG1946	Acyl-CoA thioesterase
H8Z74_06460	COG0824	Thioesterase
H8Z74_06465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H8Z74_06470	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H8Z74_06475	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H8Z74_06480	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H8Z74_06485	COG0268	Binds directly to 16S ribosomal RNA
H8Z74_06495	COG0196	riboflavin kinase activity
H8Z74_06500	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H8Z74_06505	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H8Z74_06510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H8Z74_06525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H8Z74_06530	COG1845	cytochrome c oxidase, subunit III
H8Z74_06535	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H8Z74_06550	COG3152	Membrane
H8Z74_06560	COG2207	Transcriptional regulator
H8Z74_06575	COG1366	Belongs to the anti-sigma-factor antagonist family
H8Z74_06580	COG1366	Belongs to the anti-sigma-factor antagonist family
H8Z74_06585	COG2172	sigma factor antagonist activity
H8Z74_06610	COG4771	TonB-dependent receptor
H8Z74_06620	COG5507	3-demethylubiquinone-9 3-methyltransferase
H8Z74_06625	COG2205	protein histidine kinase activity
H8Z74_06635	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8Z74_06640	COG4999	Histidine kinase
H8Z74_06640	COG3850	Histidine kinase
H8Z74_06640	COG3437	response regulator, receiver
H8Z74_06640	COG2205	protein histidine kinase activity
H8Z74_06645	COG0784	Response regulator, receiver
H8Z74_06645	COG4191	Histidine kinase
H8Z74_06675	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8Z74_06680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H8Z74_06690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8Z74_06695	COG0228	four-way junction DNA binding
H8Z74_06700	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H8Z74_06705	COG0336	Belongs to the RNA methyltransferase TrmD family
H8Z74_06710	COG0335	large ribosomal subunit rRNA binding
H8Z74_06715	COG0534	Mate efflux family protein
H8Z74_06735	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H8Z74_06745	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H8Z74_06755	COG3209	COG3209 Rhs family protein
H8Z74_06775	COG3250	beta-galactosidase activity
H8Z74_06780	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H8Z74_06800	COG1960	acyl-CoA dehydrogenase activity
H8Z74_06805	COG1024	Enoyl-CoA hydratase
H8Z74_06825	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8Z74_06825	COG1024	Enoyl-CoA hydratase
H8Z74_06840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8Z74_06845	COG0481	GTPase activity
H8Z74_06860	COG0571	ribonuclease III activity
H8Z74_06865	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H8Z74_06870	COG1381	Involved in DNA repair and RecF pathway recombination
H8Z74_06880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8Z74_06885	COG2954	triphosphatase activity
H8Z74_06890	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H8Z74_06895	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
H8Z74_06900	COG3046	protein related to deoxyribodipyrimidine photolyase
H8Z74_06905	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z74_06910	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H8Z74_06915	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H8Z74_06920	COG1278	Cold shock
H8Z74_06925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z74_06935	COG1201	RNA secondary structure unwinding
H8Z74_06940	COG1793	dna ligase
H8Z74_06950	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8Z74_06950	COG1793	dna ligase
H8Z74_06980	COG0183	Belongs to the thiolase family
H8Z74_07005	COG1451	nucleotide metabolic process
H8Z74_07010	COG5487	UPF0391 membrane protein
H8Z74_07020	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H8Z74_07035	COG1077	Cell shape determining protein MreB Mrl
H8Z74_07040	COG1047	Peptidyl-prolyl cis-trans
H8Z74_07045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H8Z74_07050	COG2824	Alkylphosphonate utilization operon protein PhnA
H8Z74_07055	COG1902	pentaerythritol trinitrate reductase activity
H8Z74_07060	COG2814	Major facilitator Superfamily
H8Z74_07095	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H8Z74_07095	COG0392	lysyltransferase activity
H8Z74_07105	COG0251	oxidation-reduction process
H8Z74_07110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H8Z74_07125	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H8Z74_07150	COG1595	DNA-templated transcription, initiation
H8Z74_07165	COG2878	Part of a membrane complex involved in electron transport
H8Z74_07175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z74_07175	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z74_07190	COG1131	(ABC) transporter
H8Z74_07195	COG0346	lactoylglutathione lyase activity
H8Z74_07200	COG0833	amino acid
H8Z74_07205	COG2040	homocysteine
H8Z74_07215	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8Z74_07235	COG1695	Transcriptional regulator
H8Z74_07255	COG1981	membrane
H8Z74_07270	COG0825	malonyl-CoA metabolic process
H8Z74_07280	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H8Z74_07285	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z74_07290	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z74_07295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z74_07300	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z74_07315	COG0750	zinc metalloprotease
H8Z74_07320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H8Z74_07325	COG0575	Belongs to the CDS family
H8Z74_07330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H8Z74_07335	COG0233	cytoplasmic translational termination
H8Z74_07340	COG0528	UMP kinase activity
H8Z74_07350	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H8Z74_07355	COG0052	Belongs to the universal ribosomal protein uS2 family
H8Z74_07395	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H8Z74_07405	COG1393	Belongs to the ArsC family
H8Z74_07410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z74_07415	COG0367	asparagine synthase
H8Z74_07425	COG4774	siderophore transport
H8Z74_07440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8Z74_07470	COG1566	PFAM secretion protein HlyD family protein
H8Z74_07475	COG2814	Major facilitator Superfamily
H8Z74_07525	COG0339	signal peptide processing
H8Z74_07530	COG0386	Belongs to the glutathione peroxidase family
H8Z74_07585	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H8Z74_07590	COG0084	hydrolase, TatD family'
H8Z74_07605	COG1960	acyl-CoA dehydrogenase activity
H8Z74_07620	COG0367	asparagine synthase
H8Z74_07630	COG0305	Participates in initiation and elongation during chromosome replication
H8Z74_07635	COG0415	Belongs to the DNA photolyase family
H8Z74_07645	COG0583	DNA-binding transcription factor activity
H8Z74_07660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z74_07690	COG3706	GGDEF domain
H8Z74_07715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H8Z74_07730	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z74_07740	COG0497	DNA recombination
H8Z74_07745	COG1420	regulation of RNA biosynthetic process
H8Z74_07750	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H8Z74_07755	COG0443	Heat shock 70 kDa protein
H8Z74_07760	COG0484	heat shock protein binding
H8Z74_07770	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H8Z74_07800	COG0583	DNA-binding transcription factor activity
H8Z74_07805	COG1132	(ABC) transporter
H8Z74_07840	COG2850	peptidyl-arginine hydroxylation
H8Z74_07860	COG1253	flavin adenine dinucleotide binding
H8Z74_07890	COG1131	(ABC) transporter
H8Z74_07895	COG1725	Transcriptional regulator
H8Z74_07905	COG0386	Belongs to the glutathione peroxidase family
H8Z74_07920	COG2900	Belongs to the SlyX family
H8Z74_07945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z74_07955	COG1410	methionine synthase
H8Z74_07955	COG0646	methionine synthase
H8Z74_07960	COG1410	methionine synthase
H8Z74_07960	COG0646	methionine synthase
H8Z74_07965	COG2226	methyltransferase
H8Z74_07970	COG1960	acyl-CoA dehydrogenase activity
H8Z74_07975	COG1960	acyl-CoA dehydrogenase activity
H8Z74_07980	COG1960	acyl-CoA dehydrogenase activity
H8Z74_07985	COG1960	acyl-CoA dehydrogenase activity
H8Z74_08000	COG0557	exoribonuclease II activity
H8Z74_08010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8Z74_08020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8Z74_08030	COG0704	Plays a role in the regulation of phosphate uptake
H8Z74_08035	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8Z74_08040	COG0581	inorganic phosphate transmembrane transporter activity
H8Z74_08045	COG0573	inorganic phosphate transmembrane transporter activity
H8Z74_08050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8Z74_08075	COG0659	secondary active sulfate transmembrane transporter activity
H8Z74_08080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H8Z74_08090	COG1024	Enoyl-CoA hydratase
H8Z74_08100	COG0494	nUDIX hydrolase
H8Z74_08135	COG0488	(ABC) transporter
H8Z74_08145	COG0116	Belongs to the methyltransferase superfamily
H8Z74_08145	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H8Z74_08150	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8Z74_08175	COG2925	Exonuclease
H8Z74_08185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z74_08190	COG3844	kynureninase activity
H8Z74_08200	COG0662	Cupin 2, conserved barrel domain protein
H8Z74_08205	COG0288	reversible hydration of carbon dioxide
H8Z74_08255	COG3002	Belongs to the UPF0753 family
H8Z74_08280	COG2808	Putative FMN-binding domain
H8Z74_08300	COG0017	Asparaginyl-tRNA synthetase
H8Z74_08305	COG0316	Belongs to the HesB IscA family
H8Z74_08310	COG0360	Binds together with S18 to 16S ribosomal RNA
H8Z74_08315	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H8Z74_08320	COG0359	binds to the 23S rRNA
H8Z74_08330	COG3115	cell septum assembly
H8Z74_08340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z74_08345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8Z74_08350	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H8Z74_08365	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H8Z74_08375	COG4993	Dehydrogenase
H8Z74_08385	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H8Z74_08395	COG2986	histidine ammonia-lyase
H8Z74_08400	COG1228	amidohydrolase
H8Z74_08445	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H8Z74_08450	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H8Z74_08455	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H8Z74_08460	COG0077	Prephenate dehydratase
H8Z74_08460	COG1605	Chorismate mutase
H8Z74_08465	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H8Z74_08480	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H8Z74_08485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8Z74_08490	COG0583	DNA-binding transcription factor activity
H8Z74_08555	COG0840	transmembrane signaling receptor activity
H8Z74_08580	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H8Z74_08585	COG0784	Response regulator, receiver
H8Z74_08585	COG4191	Histidine kinase
H8Z74_08600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z74_08610	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H8Z74_08620	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8Z74_08635	COG1595	DNA-templated transcription, initiation
H8Z74_08685	COG2244	polysaccharide biosynthetic process
H8Z74_08715	COG2264	protein methyltransferase activity
H8Z74_08725	COG0438	transferase activity, transferring glycosyl groups
H8Z74_08740	COG1136	(ABC) transporter
H8Z74_08750	COG0477	Major facilitator Superfamily
H8Z74_08755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z74_08770	COG1253	flavin adenine dinucleotide binding
H8Z74_08780	COG0306	phosphate transporter
H8Z74_08805	COG0504	CTP synthase activity
H8Z74_08810	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H8Z74_08820	COG0148	phosphopyruvate hydratase activity
H8Z74_08825	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H8Z74_08830	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H8Z74_08835	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H8Z74_08840	COG0585	pseudouridine synthase activity
H8Z74_08845	COG2840	Smr protein MutS2
H8Z74_08850	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H8Z74_08855	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H8Z74_08860	COG1238	metal cluster binding
H8Z74_08875	COG1534	Rna-binding protein
H8Z74_08880	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H8Z74_08890	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8Z74_08895	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8Z74_08905	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H8Z74_08910	COG1546	Belongs to the CinA family
H8Z74_08920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8Z74_08925	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H8Z74_08930	COG2137	regulation of response to DNA damage stimulus
H8Z74_08935	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H8Z74_08940	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H8Z74_08955	COG1741	Belongs to the pirin family
H8Z74_08960	COG0583	DNA-binding transcription factor activity
H8Z74_08985	COG0352	thiamine-phosphate diphosphorylase activity
H8Z74_08985	COG0351	phosphomethylpyrimidine kinase
H8Z74_09000	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H8Z74_09005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8Z74_09020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8Z74_09030	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H8Z74_09035	COG3734	2-keto-3-deoxy-galactonokinase
H8Z74_09045	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z74_09050	COG0800	Aldolase
H8Z74_09085	COG1501	Belongs to the glycosyl hydrolase 31 family
H8Z74_09095	COG1070	Carbohydrate kinase
H8Z74_09100	COG2115	Belongs to the xylose isomerase family
H8Z74_09105	COG0477	Major facilitator Superfamily
H8Z74_09125	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8Z74_09130	COG1469	GTP cyclohydrolase I activity
H8Z74_09150	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H8Z74_09155	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H8Z74_09160	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H8Z74_09185	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z74_09195	COG3706	GGDEF domain
H8Z74_09195	COG5001	Diguanylate cyclase
H8Z74_09195	COG2203	Gaf domain
H8Z74_09195	COG4251	negative regulation of phosphorylation
H8Z74_09205	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z74_09210	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H8Z74_09220	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H8Z74_09225	COG0671	phosphoesterase, PA-phosphatase related
H8Z74_09240	COG1794	racemase activity, acting on amino acids and derivatives
H8Z74_09245	COG0697	spore germination
H8Z74_09250	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H8Z74_09255	COG0167	dihydroorotate dehydrogenase activity
H8Z74_09270	COG1012	belongs to the aldehyde dehydrogenase family
H8Z74_09285	COG1215	transferase activity, transferring glycosyl groups
H8Z74_09290	COG1649	PFAM Uncharacterised BCR, COG1649
H8Z74_09290	COG0726	polysaccharide deacetylase
H8Z74_09375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z74_09380	COG0124	histidyl-tRNA synthetase
H8Z74_09390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H8Z74_09395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H8Z74_09400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z74_09405	COG0131	Imidazoleglycerol-phosphate dehydratase
H8Z74_09405	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H8Z74_09410	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H8Z74_09415	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H8Z74_09420	COG0107	imidazoleglycerol-phosphate synthase activity
H8Z74_09425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H8Z74_09425	COG0140	phosphoribosyl-ATP diphosphatase activity
H8Z74_09440	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H8Z74_09445	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H8Z74_09450	COG0235	Class ii aldolase
H8Z74_09455	COG0531	amino acid
H8Z74_09460	COG0531	amino acid
H8Z74_09470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8Z74_09475	COG0277	FAD linked oxidase domain protein
H8Z74_09495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8Z74_09540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8Z74_09545	COG2258	MOSC domain
H8Z74_09550	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H8Z74_09555	COG0505	Belongs to the CarA family
H8Z74_09565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H8Z74_09570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z74_09580	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H8Z74_09620	COG3279	Response regulator of the LytR AlgR family
H8Z74_09630	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8Z74_09640	COG2205	protein histidine kinase activity
H8Z74_09640	COG2198	Histidine kinase
H8Z74_09640	COG0784	Response regulator, receiver
H8Z74_09645	COG1024	Enoyl-CoA hydratase
H8Z74_09680	COG2267	carboxylic ester hydrolase activity
H8Z74_09690	COG2201	protein-glutamate methylesterase activity
H8Z74_09695	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H8Z74_09705	COG0840	transmembrane signaling receptor activity
H8Z74_09715	COG0835	chemotaxis
H8Z74_09725	COG0840	transmembrane signaling receptor activity
H8Z74_09730	COG0840	transmembrane signaling receptor activity
H8Z74_09745	COG0840	transmembrane signaling receptor activity
H8Z74_09750	COG0840	transmembrane signaling receptor activity
H8Z74_09755	COG0840	transmembrane signaling receptor activity
H8Z74_09760	COG0840	transmembrane signaling receptor activity
H8Z74_09765	COG0840	transmembrane signaling receptor activity
H8Z74_09775	COG0840	transmembrane signaling receptor activity
H8Z74_09795	COG2198	Histidine kinase
H8Z74_09795	COG0643	Histidine kinase
H8Z74_09800	COG0745	RESPONSE REGULATOR receiver
H8Z74_09820	COG1360	Flagellar Motor Protein
H8Z74_09825	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H8Z74_09860	COG0641	radical SAM
H8Z74_09870	COG0784	Response regulator, receiver
H8Z74_09870	COG0643	Histidine kinase
H8Z74_09870	COG2198	Histidine kinase
H8Z74_09900	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8Z74_09925	COG1684	flagellar biosynthetic protein fliR
H8Z74_09990	COG1677	Flagellar hook-basal body complex protein FliE
H8Z74_10020	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z74_10025	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z74_10030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z74_10050	COG2201	protein-glutamate methylesterase activity
H8Z74_10080	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H8Z74_10090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8Z74_10095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8Z74_10105	COG3951	Flagellar rod assembly protein muramidase FlgJ
H8Z74_10105	COG1705	Flagellar rod assembly protein muramidase FlgJ
H8Z74_10110	COG1706	bacterial-type flagellum-dependent cell motility
H8Z74_10115	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H8Z74_10130	COG4787	bacterial-type flagellum-dependent cell motility
H8Z74_10140	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H8Z74_10145	COG1558	bacterial-type flagellum-dependent cell motility
H8Z74_10155	COG0835	chemotaxis
H8Z74_10155	COG0784	Response regulator, receiver
H8Z74_10175	COG5002	protein histidine kinase activity
H8Z74_10205	COG2915	High frequency lysogenization protein hflD homolog
H8Z74_10210	COG0482	sulfurtransferase activity
H8Z74_10225	COG0542	response to heat
H8Z74_10245	COG0492	ferredoxin-NADP+ reductase activity
H8Z74_10250	COG1674	ftsk spoiiie
H8Z74_10260	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H8Z74_10270	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H8Z74_10275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8Z74_10280	COG0183	Belongs to the thiolase family
H8Z74_10285	COG1024	Enoyl-CoA hydratase
H8Z74_10285	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8Z74_10300	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H8Z74_10310	COG1426	Protein conserved in bacteria
H8Z74_10320	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z74_10325	COG1160	GTP binding
H8Z74_10330	COG0303	'Molybdopterin
H8Z74_10335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H8Z74_10370	COG0708	Exodeoxyribonuclease III
H8Z74_10380	COG0303	'Molybdopterin
H8Z74_10385	COG0746	molybdenum cofactor guanylyltransferase activity
H8Z74_10400	COG1914	H( )-stimulated, divalent metal cation uptake system
H8Z74_10415	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H8Z74_10420	COG0668	transmembrane transport
H8Z74_10430	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H8Z74_10445	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z74_10450	COG1183	phosphatidylcholine synthase activity
H8Z74_10460	COG3243	poly(R)-hydroxyalkanoic acid synthase
H8Z74_10475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z74_10475	COG0723	plastoquinol--plastocyanin reductase activity
H8Z74_10485	COG2183	response to ionizing radiation
H8Z74_10570	COG0800	Aldolase
H8Z74_10575	COG0129	dihydroxy-acid dehydratase activity
H8Z74_10580	COG0363	glucosamine-6-phosphate deaminase activity
H8Z74_10585	COG0837	glucose binding
H8Z74_10590	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8Z74_10615	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H8Z74_10630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H8Z74_10635	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H8Z74_10645	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8Z74_10650	COG1136	(ABC) transporter
H8Z74_10665	COG0811	peptide transport
H8Z74_10675	COG1132	(ABC) transporter
H8Z74_10680	COG1663	tetraacyldisaccharide 4'-kinase activity
H8Z74_10685	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H8Z74_10690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8Z74_10700	COG0322	excinuclease ABC activity
H8Z74_10705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8Z74_10715	COG0582	viral genome integration into host DNA
H8Z74_10820	COG2003	Belongs to the UPF0758 family
H8Z74_10995	COG0270	DNA (cytosine-5-)-methyltransferase activity
H8Z74_11000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z74_11005	COG0629	single-stranded DNA binding
H8Z74_11140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z74_11160	COG0582	viral genome integration into host DNA
H8Z74_11170	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H8Z74_11190	COG1054	Belongs to the UPF0176 family
H8Z74_11200	COG1530	ribonuclease E activity
H8Z74_11210	COG3064	Membrane
H8Z74_11215	COG0428	transporter
H8Z74_11225	COG2154	pterin-4-alpha-carbinolamine dehydratase
H8Z74_11230	COG0316	Belongs to the HesB IscA family
H8Z74_11230	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H8Z74_11275	COG1073	alpha beta
H8Z74_11275	COG2226	methyltransferase
H8Z74_11285	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z74_11315	COG1238	metal cluster binding
H8Z74_11350	COG3279	Response regulator of the LytR AlgR family
H8Z74_11390	COG4566	intracellular signal transduction
H8Z74_11400	COG5001	Diguanylate cyclase
H8Z74_11420	COG3685	Protein conserved in bacteria
H8Z74_11445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8Z74_11445	COG1648	precorrin-2 dehydrogenase activity
H8Z74_11460	COG2814	Major facilitator Superfamily
H8Z74_11475	COG1335	isochorismatase
H8Z74_11495	COG2197	response regulator
H8Z74_11515	COG0583	DNA-binding transcription factor activity
H8Z74_11520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8Z74_11525	COG3002	Belongs to the UPF0753 family
H8Z74_11535	COG1396	sequence-specific DNA binding
H8Z74_11540	COG5489	Protein of unknown function (DUF736)
H8Z74_11550	COG2003	Belongs to the UPF0758 family
H8Z74_11580	COG0582	viral genome integration into host DNA
H8Z74_11595	COG4774	siderophore transport
H8Z74_11625	COG2336	PFAM SpoVT AbrB
H8Z74_11650	COG4206	TonB-dependent receptor
H8Z74_11690	COG2274	protein secretion by the type I secretion system
H8Z74_11745	COG0270	DNA (cytosine-5-)-methyltransferase activity
H8Z74_11885	COG2084	Dehydrogenase
H8Z74_11905	COG2003	Belongs to the UPF0758 family
H8Z74_11940	COG0582	viral genome integration into host DNA
H8Z74_11945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8Z74_11945	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z74_11955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H8Z74_11965	COG0475	glutathione-regulated potassium exporter activity
H8Z74_11965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8Z74_11970	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H8Z74_11980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8Z74_11985	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H8Z74_11995	COG0776	regulation of translation
H8Z74_12000	COG0539	negative regulation of cytoplasmic translation
H8Z74_12005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H8Z74_12020	COG2957	Belongs to the agmatine deiminase family
H8Z74_12025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8Z74_12050	COG0395	ABC-type sugar transport system, permease component
H8Z74_12055	COG1175	transmembrane transport
H8Z74_12085	COG2350	Protein conserved in bacteria
H8Z74_12090	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H8Z74_12095	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H8Z74_12100	COG1187	pseudouridine synthase activity
H8Z74_12120	COG0436	Aminotransferase
H8Z74_12125	COG4133	protoheme IX ABC transporter activity
H8Z74_12145	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H8Z74_12150	COG1138	Cytochrome C-type biogenesis protein
H8Z74_12170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z74_12175	COG1278	Cold shock
H8Z74_12180	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H8Z74_12185	COG4988	ABC transporter
H8Z74_12205	COG1294	oxidase, subunit
H8Z74_12230	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H8Z74_12240	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H8Z74_12250	COG0165	Argininosuccinate lyase
H8Z74_12255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H8Z74_12265	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H8Z74_12270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z74_12280	COG0137	argininosuccinate synthase activity
H8Z74_12285	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H8Z74_12295	COG0215	cysteine-tRNA ligase activity
H8Z74_12300	COG2166	iron-sulfur cluster assembly
H8Z74_12315	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H8Z74_12320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H8Z74_12350	COG4302	ethanolamine ammonia-lyase activity
H8Z74_12405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8Z74_12410	COG0402	S-adenosylhomocysteine deaminase activity
H8Z74_12420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8Z74_12425	COG1509	lysine 2,3-aminomutase activity
H8Z74_12430	COG5001	Diguanylate cyclase
H8Z74_12430	COG3300	MHYT domain
H8Z74_12445	COG0483	inositol monophosphate 1-phosphatase activity
H8Z74_12450	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8Z74_12465	COG0488	(ABC) transporter
H8Z74_12470	COG0513	Belongs to the DEAD box helicase family
H8Z74_12475	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8Z74_12480	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H8Z74_12495	COG0625	glutathione transferase activity
H8Z74_12505	COG4681	YaeQ
H8Z74_12510	COG2081	HI0933 family
H8Z74_12520	COG0501	Belongs to the peptidase M48B family
H8Z74_12525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z74_12530	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z74_12555	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H8Z74_12560	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8Z74_12565	COG0802	atpase or kinase
H8Z74_12570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8Z74_12570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H8Z74_12575	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8Z74_12580	COG1570	exodeoxyribonuclease VII activity
H8Z74_12790	COG0835	chemotaxis
H8Z74_12795	COG0840	transmembrane signaling receptor activity
H8Z74_12800	COG2094	Belongs to the DNA glycosylase MPG family
H8Z74_12805	COG1201	RNA secondary structure unwinding
H8Z74_12825	COG2969	positive regulation of protein catabolic process
H8Z74_12830	COG0625	glutathione transferase activity
H8Z74_12835	COG2857	Cytochrome c1
H8Z74_12840	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8Z74_12845	COG0723	plastoquinol--plastocyanin reductase activity
H8Z74_12850	COG0741	lytic transglycosylase activity
H8Z74_12865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8Z74_12870	COG1702	phosphate starvation-inducible protein PhoH
H8Z74_12880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H8Z74_12890	COG4535	Mg2 and Co2 transporter CorC
H8Z74_12905	COG1012	belongs to the aldehyde dehydrogenase family
H8Z74_12910	COG1177	transmembrane transport
H8Z74_12915	COG1176	ABC-type spermidine putrescine transport system, permease component I
H8Z74_12920	COG3842	ATPase activity
H8Z74_12940	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H8Z74_12955	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H8Z74_12960	COG0174	glutamine synthetase
H8Z74_12965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z74_12975	COG2703	oxygen carrier activity
H8Z74_12995	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H8Z74_13000	COG2223	nitrite transmembrane transporter activity
H8Z74_13005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H8Z74_13015	COG2733	membrane
H8Z74_13020	COG2205	protein histidine kinase activity
H8Z74_13020	COG0784	Response regulator, receiver
H8Z74_13020	COG5002	protein histidine kinase activity
H8Z74_13030	COG0477	Major facilitator Superfamily
H8Z74_13040	COG2902	Dehydrogenase
H8Z74_13050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z74_13055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z74_13060	COG1609	Transcriptional regulator
H8Z74_13065	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z74_13065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8Z74_13070	COG1105	Belongs to the carbohydrate kinase PfkB family
H8Z74_13075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8Z74_13075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8Z74_13120	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8Z74_13130	COG1862	Preprotein translocase
H8Z74_13135	COG0343	queuine tRNA-ribosyltransferase activity
H8Z74_13140	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H8Z74_13175	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H8Z74_13180	COG3291	Pkd domain containing protein
H8Z74_13185	COG0405	Gamma-glutamyltransferase
H8Z74_13190	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8Z74_13200	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H8Z74_13205	COG0742	ribosomal rna small subunit methyltransferase
H8Z74_13210	COG0326	Molecular chaperone. Has ATPase activity
H8Z74_13285	COG0531	amino acid
H8Z74_13300	COG0006	proline dipeptidase activity
H8Z74_13310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8Z74_13325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z74_13330	COG3938	Belongs to the proline racemase family
H8Z74_13340	COG0552	protein localization to endoplasmic reticulum
H8Z74_13345	COG1194	a g-specific adenine glycosylase
H8Z74_13350	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H8Z74_13355	COG4191	Histidine kinase
H8Z74_13355	COG0784	Response regulator, receiver
H8Z74_13370	COG0322	excinuclease ABC activity
H8Z74_13385	COG3040	lipid binding
H8Z74_13400	COG1960	acyl-CoA dehydrogenase activity
H8Z74_13410	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H8Z74_13430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z74_13435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z74_13440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z74_13465	COG0438	transferase activity, transferring glycosyl groups
H8Z74_13475	COG0438	transferase activity, transferring glycosyl groups
H8Z74_13480	COG0438	transferase activity, transferring glycosyl groups
H8Z74_13530	COG0072	phenylalanine-tRNA ligase activity
H8Z74_13530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z74_13535	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H8Z74_13550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H8Z74_13555	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H8Z74_13580	COG1082	Xylose isomerase domain protein TIM barrel
H8Z74_13670	COG3702	type iv secretory pathway
H8Z74_13690	COG2948	multi-organism process
H8Z74_13710	COG3505	Type IV secretory pathway VirD4
H8Z74_13725	COG0556	nucleotide-excision repair
H8Z74_13810	COG4695	Portal protein
H8Z74_13855	COG3179	chitinase
H8Z74_13910	COG3275	phosphorelay sensor kinase activity
H8Z74_13925	COG2095	MarC family integral membrane protein
H8Z74_13935	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8Z74_13970	COG1185	polyribonucleotide nucleotidyltransferase activity
H8Z74_13975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H8Z74_13980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H8Z74_13985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H8Z74_13990	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H8Z74_13995	COG0195	Participates in both transcription termination and antitermination
H8Z74_14000	COG0779	Required for maturation of 30S ribosomal subunits
H8Z74_14010	COG1007	ATP synthesis coupled electron transport
H8Z74_14035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z74_14040	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H8Z74_14050	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H8Z74_14055	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H8Z74_14060	COG0649	NAD binding
H8Z74_14065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z74_14070	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z74_14075	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z74_14090	COG0149	triose-phosphate isomerase activity
H8Z74_14095	COG0300	oxidoreductase activity
H8Z74_14125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8Z74_14130	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H8Z74_14135	COG0159	tryptophan synthase activity
H8Z74_14145	COG0133	tryptophan synthase activity
H8Z74_14155	COG0135	phosphoribosylanthranilate isomerase activity
H8Z74_14160	COG0101	tRNA pseudouridine synthase activity
H8Z74_14180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H8Z74_14185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8Z74_14190	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H8Z74_14195	COG2890	protein-(glutamine-N5) methyltransferase activity
H8Z74_14205	COG0688	phosphatidylethanolamine metabolic process
H8Z74_14215	COG0433	COG0433 Predicted ATPase
H8Z74_14220	COG0494	nUDIX hydrolase
H8Z74_14235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z74_14240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8Z74_14265	COG0717	Belongs to the dCTP deaminase family
H8Z74_14270	COG0489	protein tyrosine kinase activity
H8Z74_14290	COG3590	peptidase
H8Z74_14295	COG3590	peptidase
H8Z74_14315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8Z74_14320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z74_14325	COG2311	Membrane
H8Z74_14330	COG1047	Peptidyl-prolyl cis-trans
H8Z74_14335	COG0791	NLP P60 protein
H8Z74_14340	COG0791	NLP P60 protein
H8Z74_14350	COG4106	trans-aconitate 2-methyltransferase activity
H8Z74_14355	COG1301	dicarboxylic acid transport
H8Z74_14360	COG1785	Belongs to the alkaline phosphatase family
H8Z74_14365	COG0037	tRNA processing
H8Z74_14370	COG1722	exodeoxyribonuclease VII activity
H8Z74_14375	COG0142	geranyltranstransferase activity
H8Z74_14380	COG4104	PAAR repeat-containing protein
H8Z74_14390	COG0312	modulator of DNA gyrase
H8Z74_14395	COG3028	Belongs to the UPF0307 family
H8Z74_14400	COG0312	modulator of DNA gyrase
H8Z74_14425	COG0424	maF-like protein
H8Z74_14430	COG2968	Membrane
H8Z74_14445	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H8Z74_14460	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H8Z74_14475	COG0495	leucyl-tRNA aminoacylation
H8Z74_14485	COG3118	belongs to the thioredoxin family
H8Z74_14510	COG2155	Conserved Protein
H8Z74_14555	COG1132	(ABC) transporter
H8Z74_14585	COG1538	Outer membrane efflux protein
H8Z74_14590	COG0745	RESPONSE REGULATOR receiver
H8Z74_14595	COG5000	phosphorelay sensor kinase activity
H8Z74_14595	COG5002	protein histidine kinase activity
H8Z74_14600	COG0475	glutathione-regulated potassium exporter activity
H8Z74_14610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H8Z74_14630	COG1187	pseudouridine synthase activity
H8Z74_14635	COG5001	Diguanylate cyclase
H8Z74_14635	COG5002	protein histidine kinase activity
H8Z74_14755	COG0667	Aldo Keto reductase
H8Z74_14760	COG2814	Major facilitator Superfamily
H8Z74_14765	COG0583	DNA-binding transcription factor activity
H8Z74_14775	COG2207	Transcriptional regulator
H8Z74_14785	COG1309	transcriptional regulator
H8Z74_14795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z74_14810	COG0735	belongs to the Fur family
H8Z74_14815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z74_14840	COG4452	Inner membrane protein CreD
H8Z74_14855	COG2205	protein histidine kinase activity
H8Z74_14860	COG0745	RESPONSE REGULATOR receiver
H8Z74_14875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H8Z74_14905	COG0643	Histidine kinase
H8Z74_14905	COG2198	Histidine kinase
H8Z74_14910	COG0840	transmembrane signaling receptor activity
H8Z74_14915	COG0835	chemotaxis
H8Z74_14920	COG2202	Pas domain
H8Z74_14920	COG2200	EAL domain
H8Z74_14920	COG2199	diguanylate cyclase activity
H8Z74_14925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8Z74_14930	COG2201	protein-glutamate methylesterase activity
H8Z74_14935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z74_14940	COG3590	peptidase
H8Z74_14950	COG0588	phosphoglycerate mutase activity
H8Z74_14955	COG1515	deoxyribonuclease V activity
H8Z74_14965	COG1741	Belongs to the pirin family
H8Z74_14980	COG1741	Belongs to the pirin family
H8Z74_14985	COG1966	Carbon starvation protein
H8Z74_14990	COG2879	small protein
H8Z74_15025	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H8Z74_15030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H8Z74_15035	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8Z74_15055	COG3706	GGDEF domain
H8Z74_15055	COG5001	Diguanylate cyclase
H8Z74_15055	COG4251	negative regulation of phosphorylation
H8Z74_15055	COG2203	Gaf domain
H8Z74_15060	COG0629	single-stranded DNA binding
H8Z74_15065	COG0142	geranyltranstransferase activity
H8Z74_15075	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H8Z74_15090	COG0527	aspartate kinase activity
H8Z74_15095	COG0384	phenazine biosynthesis protein PhzF
H8Z74_15100	COG0384	phenazine biosynthesis protein PhzF
H8Z74_15110	COG1764	response to oxidative stress
H8Z74_15115	COG0540	Belongs to the ATCase OTCase family
H8Z74_15120	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H8Z74_15125	COG1678	Uncharacterized ACR, COG1678
H8Z74_15130	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z74_15145	COG5297	Belongs to the glycosyl hydrolase family 6
H8Z74_15160	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H8Z74_15175	COG0739	heme binding
H8Z74_15195	COG0693	protein deglycase activity
H8Z74_15205	COG1959	2 iron, 2 sulfur cluster binding
H8Z74_15210	COG0719	Fe-S assembly protein
H8Z74_15215	COG0396	ATPase activity
H8Z74_15220	COG0719	Fe-S assembly protein
H8Z74_15225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H8Z74_15235	COG2146	nitrite reductase [NAD(P)H] activity
H8Z74_15240	COG4774	siderophore transport
H8Z74_15245	COG3128	pkhd-type hydroxylase
H8Z74_15270	COG1477	protein flavinylation
H8Z74_15275	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8Z74_15290	COG1555	photosystem II stabilization
H8Z74_15295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z74_15305	COG3178	'Phosphotransferase
H8Z74_15310	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H8Z74_15320	COG0628	permease
H8Z74_15330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H8Z74_15340	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H8Z74_15360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H8Z74_15365	COG0271	Belongs to the BolA IbaG family
H8Z74_15375	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H8Z74_15385	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H8Z74_15390	COG1137	ATPase activity
H8Z74_15405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z74_15410	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H8Z74_15415	COG1660	Displays ATPase and GTPase activities
H8Z74_15425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z74_15430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8Z74_15435	COG2239	Acts as a magnesium transporter
H8Z74_15450	COG1294	oxidase, subunit
H8Z74_15455	COG1271	oxidase subunit
H8Z74_15465	COG1113	amino acid transport
H8Z74_15485	COG2197	response regulator
H8Z74_15495	COG0531	amino acid
H8Z74_15515	COG1234	tRNA 3'-trailer cleavage
H8Z74_15550	COG2814	Major facilitator Superfamily
H8Z74_15560	COG0754	glutathionylspermidine amidase activity
H8Z74_15585	COG1842	Phage shock protein A
H8Z74_15595	COG0259	pyridoxamine-phosphate oxidase activity
H8Z74_15600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H8Z74_15605	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H8Z74_15615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H8Z74_15695	COG0477	Major facilitator Superfamily
H8Z74_15715	COG0784	Response regulator, receiver
H8Z74_15715	COG2198	Histidine kinase
H8Z74_15715	COG2205	protein histidine kinase activity
H8Z74_15720	COG2353	YceI-like domain
H8Z74_15740	COG1760	l-serine dehydratase
H8Z74_15750	COG0460	homoserine dehydrogenase
H8Z74_15750	COG0527	aspartate kinase activity
H8Z74_15755	COG0626	cystathionine gamma-synthase activity
H8Z74_15760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z74_15765	COG0739	heme binding
H8Z74_15770	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H8Z74_15775	COG1272	protein, Hemolysin III
H8Z74_15780	COG2982	Protein involved in outer membrane biogenesis
H8Z74_15785	COG0517	IMP dehydrogenase activity
H8Z74_15785	COG0516	GMP reductase activity
H8Z74_15790	COG0463	Glycosyl transferase, family 2
H8Z74_15795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8Z74_15800	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H8Z74_15810	COG4771	TonB-dependent receptor
H8Z74_15830	COG1309	transcriptional regulator
H8Z74_15840	COG1960	acyl-CoA dehydrogenase activity
H8Z74_15870	COG0509	glycine decarboxylation via glycine cleavage system
H8Z74_15875	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H8Z74_15885	COG0330	HflC and HflK could
H8Z74_15890	COG1742	UPF0060 membrane protein
H8Z74_15895	COG3956	TIGRFAM MazG family protein
H8Z74_15905	COG0494	nUDIX hydrolase
H8Z74_15915	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H8Z74_15920	COG0837	glucose binding
H8Z74_15935	COG1388	LysM domain
H8Z74_15935	COG3858	chitin binding
H8Z74_15940	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H8Z74_15950	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z74_15965	COG0531	amino acid
H8Z74_15975	COG1486	melibiose metabolic process
H8Z74_15985	COG3537	Alpha-1,2-mannosidase
H8Z74_16020	COG3142	Participates in the control of copper homeostasis
H8Z74_16025	COG1446	asparaginase
H8Z74_16050	COG0840	transmembrane signaling receptor activity
H8Z74_16055	COG0835	chemotaxis
H8Z74_16070	COG0189	ligase activity
H8Z74_16080	COG1397	ADP-ribosylglycohydrolase
H8Z74_16090	COG1199	ATP-dependent helicase activity
H8Z74_16100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8Z74_16105	COG1215	transferase activity, transferring glycosyl groups
H8Z74_16115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8Z74_16125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H8Z74_16130	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
H8Z74_16135	COG0535	radical SAM domain protein
H8Z74_16140	COG0535	radical SAM domain protein
H8Z74_16155	COG0837	glucose binding
H8Z74_16170	COG1643	Atp-dependent helicase
H8Z74_16175	COG0783	Belongs to the Dps family
H8Z74_16180	COG0514	ATP-dependent DNA helicase (RecQ)
H8Z74_16210	COG0840	transmembrane signaling receptor activity
H8Z74_16230	COG3920	Histidine kinase
H8Z74_16235	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H8Z74_16245	COG0602	queuosine metabolic process
H8Z74_16255	COG2885	chlorophyll binding
H8Z74_16260	COG0823	Involved in the tonB-independent uptake of proteins
H8Z74_16270	COG0848	biopolymer transport protein
H8Z74_16280	COG0824	Thioesterase
H8Z74_16285	COG2255	four-way junction helicase activity
H8Z74_16295	COG3158	transport of potassium into the cell
H8Z74_16300	COG0632	four-way junction helicase activity
H8Z74_16305	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H8Z74_16310	COG0217	transcriptional regulatory protein
H8Z74_16325	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H8Z74_16340	COG0477	Major facilitator Superfamily
H8Z74_16380	COG0488	(ABC) transporter
H8Z74_16410	COG4651	solute:proton antiporter activity
H8Z74_16410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8Z74_16435	COG4772	TonB-dependent receptor
H8Z74_16445	COG4264	IucA IucC family
H8Z74_16460	COG0019	diaminopimelate decarboxylase activity
H8Z74_16490	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H8Z74_16500	COG1492	cobalamin metabolic process
H8Z74_16510	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8Z74_16530	COG4206	TonB-dependent receptor
H8Z74_16535	COG0542	response to heat
H8Z74_16540	COG1116	anion transmembrane transporter activity
H8Z74_16545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z74_16550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H8Z74_16555	COG0667	Aldo Keto reductase
H8Z74_16560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z74_16565	COG4771	TonB-dependent receptor
H8Z74_16570	COG2827	Endonuclease containing a URI domain
H8Z74_16610	COG1877	trehalose-phosphatase activity
H8Z74_16615	COG3387	PFAM Glycoside hydrolase 15-related
H8Z74_16630	COG0840	transmembrane signaling receptor activity
H8Z74_16635	COG3011	Protein conserved in bacteria
H8Z74_16650	COG0564	pseudouridine synthase activity
H8Z74_16655	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z74_16665	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H8Z74_16665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8Z74_16685	COG2951	lytic endotransglycosylase activity
H8Z74_16690	COG4644	lycopene metabolic process
H8Z74_16715	COG2369	cell adhesion
H8Z74_16740	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H8Z74_16745	COG0045	succinate-CoA ligase (ADP-forming) activity
H8Z74_16760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z74_16790	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H8Z74_16795	COG0237	dephospho-CoA kinase activity
H8Z74_16830	COG5002	protein histidine kinase activity
H8Z74_16835	COG0745	RESPONSE REGULATOR receiver
H8Z74_16980	COG2022	thiamine diphosphate biosynthetic process
H8Z74_16985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H8Z74_16990	COG0471	metal ion transport
H8Z74_16990	COG3273	potassium ion transport
H8Z74_17010	COG1970	mechanosensitive ion channel activity
H8Z74_17030	COG3250	beta-galactosidase activity
H8Z74_17035	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z74_17050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8Z74_17060	COG0308	aminopeptidase N
H8Z74_17095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z74_17110	COG0529	Catalyzes the synthesis of activated sulfate
H8Z74_17110	COG2895	sulfate adenylyltransferase (ATP) activity
H8Z74_17115	COG0175	sulfate reduction
H8Z74_17120	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8Z74_17125	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8Z74_17130	COG0175	sulfate reduction
H8Z74_17150	COG2198	Histidine kinase
H8Z74_17150	COG2205	protein histidine kinase activity
H8Z74_17150	COG0784	Response regulator, receiver
H8Z74_17165	COG1648	precorrin-2 dehydrogenase activity
H8Z74_17165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8Z74_17180	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H8Z74_17185	COG3588	fructose-bisphosphate aldolase
H8Z74_17190	COG0469	pyruvate kinase activity
H8Z74_17200	COG0126	phosphoglycerate kinase activity
H8Z74_17220	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8Z74_17230	COG3047	cAMP biosynthetic process
H8Z74_17235	COG3047	cAMP biosynthetic process
H8Z74_17245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z74_17245	COG3453	Protein conserved in bacteria
H8Z74_17250	COG0725	ABC transporter, periplasmic molybdate-binding protein
H8Z74_17255	COG4149	molybdate abc transporter
H8Z74_17260	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H8Z74_17295	COG1376	ErfK ybiS ycfS ynhG family protein
H8Z74_17300	COG0739	heme binding
H8Z74_17310	COG4773	Receptor
H8Z74_17315	COG0596	Alpha beta hydrolase
H8Z74_17320	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H8Z74_17335	COG2304	oxidoreductase activity
H8Z74_17355	COG0714	Associated with various cellular activities
H8Z74_17385	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H8Z74_17410	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8Z74_17420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8Z74_17430	COG0194	GDP metabolic process
H8Z74_17435	COG1561	YicC-like family, N-terminal region
H8Z74_17440	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H8Z74_17450	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8Z74_17455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8Z74_17470	COG0006	proline dipeptidase activity
H8Z74_17480	COG0006	proline dipeptidase activity
H8Z74_17485	COG3079	Belongs to the UPF0149 family
H8Z74_17505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H8Z74_17515	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H8Z74_17525	COG2912	Transglutaminase-like superfamily
H8Z74_17530	COG1773	rubredoxin
H8Z74_17535	COG0352	thiamine-phosphate diphosphorylase activity
H8Z74_17550	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8Z74_17565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z74_17595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8Z74_17600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z74_17610	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z74_17620	COG0671	phosphoesterase, PA-phosphatase related
H8Z74_17625	COG3781	membrane
H8Z74_17635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8Z74_17640	COG0563	adenylate kinase activity
H8Z74_17655	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H8Z74_17665	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H8Z74_17685	COG3710	Transcriptional regulator
H8Z74_17690	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H8Z74_17700	COG0840	transmembrane signaling receptor activity
H8Z74_17705	COG0405	Gamma-glutamyltransferase
H8Z74_17710	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H8Z74_17730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H8Z74_17735	COG0473	3-isopropylmalate dehydrogenase activity
H8Z74_17740	COG0066	3-isopropylmalate dehydratase activity
H8Z74_17745	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H8Z74_17765	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H8Z74_17770	COG1538	Outer membrane efflux protein
H8Z74_17775	COG1519	Transferase
H8Z74_17780	COG1560	Kdo2-lipid A biosynthetic process
H8Z74_17805	COG0280	phosphate acetyltransferase
H8Z74_17805	COG0281	malic enzyme
H8Z74_17810	COG1301	dicarboxylic acid transport
H8Z74_17835	COG0583	DNA-binding transcription factor activity
H8Z74_17840	COG0667	Aldo Keto reductase
H8Z74_17855	COG2197	response regulator
H8Z74_17865	COG0642	Histidine kinase
H8Z74_17880	COG2851	Citrate transporter
H8Z74_17885	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z74_17890	COG1609	Transcriptional regulator
H8Z74_17895	COG2211	Major facilitator Superfamily
H8Z74_17920	COG1162	GTPase activity
H8Z74_17940	COG4773	Receptor
H8Z74_17945	COG0726	polysaccharide deacetylase
H8Z74_17950	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8Z74_17980	COG1307	EDD domain protein, DegV family
H8Z74_17985	COG0242	peptide deformylase activity
H8Z74_18005	COG0457	Tetratricopeptide repeat
H8Z74_18010	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H8Z74_18015	COG1215	transferase activity, transferring glycosyl groups
H8Z74_18020	COG1215	transferase activity, transferring glycosyl groups
H8Z74_18035	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H8Z74_18080	COG2188	Transcriptional regulator
H8Z74_18095	COG1450	Type ii and iii secretion system protein
H8Z74_18110	COG3166	PFAM Fimbrial assembly family protein
H8Z74_18115	COG3156	type II secretion system protein K
H8Z74_18120	COG4795	General secretion pathway protein
H8Z74_18125	COG2165	general secretion pathway protein
H8Z74_18130	COG4970	Tfp pilus assembly protein FimT
H8Z74_18135	COG2165	general secretion pathway protein
H8Z74_18145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z74_18150	COG1404	Belongs to the peptidase S8 family
H8Z74_18155	COG5295	Hep Hag repeat protein
H8Z74_18160	COG1404	Belongs to the peptidase S8 family
H8Z74_18165	COG5295	Hep Hag repeat protein
H8Z74_18170	COG0047	phosphoribosylformylglycinamidine synthase activity
H8Z74_18170	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H8Z74_18175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8Z74_18180	COG4974	Belongs to the 'phage' integrase family
H8Z74_18195	COG0795	lipopolysaccharide-transporting ATPase activity
H8Z74_18205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8Z74_18220	COG0525	valine-tRNA ligase activity
H8Z74_18255	COG1183	phosphatidylcholine synthase activity
H8Z74_18265	COG0442	prolyl-tRNA aminoacylation
H8Z74_18280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8Z74_18285	COG1127	ABC transporter
H8Z74_18290	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8Z74_18290	COG3218	ABC-type transport auxiliary lipoprotein component
H8Z74_18325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8Z74_18330	COG0662	Cupin 2, conserved barrel domain protein
H8Z74_18330	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H8Z74_18360	COG2086	electron transfer activity
H8Z74_18375	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8Z74_18375	COG0546	phosphoglycolate phosphatase activity
H8Z74_18380	COG0277	FAD linked oxidase domain protein
H8Z74_18385	COG0300	oxidoreductase activity
H8Z74_18395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z74_18415	COG2226	methyltransferase
H8Z74_18425	COG3754	Rhamnan synthesis protein F
H8Z74_18430	COG1216	Glycosyl transferase, family 2
H8Z74_18430	COG0438	transferase activity, transferring glycosyl groups
H8Z74_18435	COG0110	maltose O-acetyltransferase activity
H8Z74_18450	COG0626	cystathionine gamma-synthase activity
H8Z74_18480	COG0625	glutathione transferase activity
H8Z74_18490	COG0513	Belongs to the DEAD box helicase family
H8Z74_18500	COG4206	TonB-dependent receptor
H8Z74_18505	COG0720	synthase
H8Z74_18515	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H8Z74_18520	COG1956	GAF domain-containing protein
H8Z74_18530	COG2819	hydrolase of the alpha beta superfamily
H8Z74_18545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8Z74_18550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z74_18565	COG0339	signal peptide processing
H8Z74_18620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8Z74_18625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z74_18630	COG1136	(ABC) transporter
H8Z74_18630	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8Z74_18635	COG0577	efflux transmembrane transporter activity
H8Z74_18640	COG0577	efflux transmembrane transporter activity
H8Z74_18655	COG4191	Histidine kinase
H8Z74_18660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8Z74_18675	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H8Z74_18680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H8Z74_18685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H8Z74_18690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H8Z74_18695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H8Z74_18700	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8Z74_18710	COG0356	it plays a direct role in the translocation of protons across the membrane
H8Z74_18730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8Z74_18740	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8Z74_18780	COG2011	ABC-type metal ion transport system permease component
H8Z74_18785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H8Z74_18790	COG0697	spore germination
H8Z74_18795	COG1666	GTP binding
H8Z74_18805	COG5002	protein histidine kinase activity
H8Z74_18805	COG2198	Histidine kinase
H8Z74_18805	COG0784	Response regulator, receiver
H8Z74_18825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8Z74_18830	COG1187	pseudouridine synthase activity
H8Z74_18835	COG2813	Specifically methylates the guanine in position
H8Z74_18855	COG2205	protein histidine kinase activity
H8Z74_18855	COG2202	Pas domain
H8Z74_18875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8Z74_18880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z74_18935	COG0842	Transport permease protein
H8Z74_18940	COG1131	(ABC) transporter
H8Z74_18945	COG0025	NhaP-type Na H and K H
H8Z74_18950	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H8Z74_18955	COG1573	uracil-dna glycosylase
H8Z74_18965	COG3384	dioxygenase
H8Z74_18975	COG0583	DNA-binding transcription factor activity
H8Z74_18985	COG0667	Aldo Keto reductase
H8Z74_18995	COG3590	peptidase
H8Z74_19015	COG0531	amino acid
H8Z74_19030	COG2972	Histidine kinase
H8Z74_19045	COG3685	Protein conserved in bacteria
H8Z74_19050	COG3546	catalase activity
H8Z74_19095	COG1271	oxidase subunit
H8Z74_19100	COG1294	oxidase, subunit
H8Z74_19115	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z74_19120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8Z74_19140	COG1132	(ABC) transporter
H8Z74_19155	COG1063	alcohol dehydrogenase
H8Z74_19230	COG0251	oxidation-reduction process
H8Z74_19245	COG0840	transmembrane signaling receptor activity
H8Z74_19260	COG0583	DNA-binding transcription factor activity
H8Z74_19265	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8Z74_19310	COG0024	Methionine aminopeptidase
H8Z74_19345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8Z74_19350	COG1490	D-aminoacyl-tRNA deacylase activity
H8Z74_19355	COG1560	Kdo2-lipid A biosynthetic process
H8Z74_19405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8Z74_19405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H8Z74_19410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H8Z74_19415	COG0242	peptide deformylase activity
H8Z74_19420	COG1652	LysM domain
H8Z74_19425	COG0758	DNA mediated transformation
H8Z74_19445	COG1754	DNA topoisomerase type I activity
H8Z74_19445	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z74_19450	COG0009	L-threonylcarbamoyladenylate synthase
H8Z74_19465	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z74_19475	COG0616	signal peptide processing
H8Z74_19480	COG0534	Mate efflux family protein
H8Z74_19500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H8Z74_19505	COG0625	glutathione transferase activity
H8Z74_19520	COG1252	NADH dehydrogenase
H8Z74_19525	COG2860	membrane
H8Z74_19530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8Z74_19535	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H8Z74_19540	COG2201	protein-glutamate methylesterase activity
H8Z74_19545	COG2177	Part of the ABC transporter FtsEX involved in
H8Z74_19550	COG2884	Cell division ATP-binding protein ftsE
H8Z74_19555	COG0513	Belongs to the DEAD box helicase family
H8Z74_19560	COG3118	belongs to the thioredoxin family
H8Z74_19565	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H8Z74_19570	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H8Z74_19575	COG0583	DNA-binding transcription factor activity
H8Z74_19620	COG1518	maintenance of DNA repeat elements
H8Z74_19625	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H8Z74_19635	COG1652	LysM domain
H8Z74_19640	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8Z74_19640	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8Z74_19645	COG1473	amidohydrolase
H8Z74_19650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z74_19655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z74_19665	COG5383	Protein conserved in bacteria
H8Z74_19705	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H8Z74_19710	COG3023	N-Acetylmuramoyl-L-alanine amidase
H8Z74_19720	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z74_19730	COG0531	amino acid
H8Z74_19745	COG4682	membrane
H8Z74_19750	COG2133	pyrroloquinoline quinone binding
H8Z74_19760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H8Z74_19765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H8Z74_19775	COG1610	YqeY-like protein
H8Z74_19780	COG1295	ribonuclease BN
H8Z74_19785	COG0358	DNA primase activity
H8Z74_19800	COG0109	protoheme IX farnesyltransferase activity
H8Z74_19830	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H8Z74_19845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H8Z74_19885	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H8Z74_19890	COG0739	heme binding
H8Z74_19895	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H8Z74_19905	COG2223	nitrite transmembrane transporter activity
H8Z74_19910	COG0708	Exodeoxyribonuclease III
H8Z74_19915	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8Z74_19925	COG1192	Involved in chromosome partitioning
H8Z74_19930	COG1475	DNA binding
H8Z74_19945	COG0463	Glycosyl transferase, family 2
H8Z74_19965	COG0756	dUTP diphosphatase activity
H8Z74_19970	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H8Z74_19975	COG2003	Belongs to the UPF0758 family
H8Z74_19980	COG0018	arginyl-trna synthetase
H8Z74_19995	COG4221	oxidoreductase activity
H8Z74_20000	COG2755	lipolytic protein G-D-S-L family
H8Z74_20000	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H8Z74_20010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8Z74_20015	COG1166	arginine decarboxylase activity
H8Z74_20020	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H8Z74_20055	COG0606	chelatase, subunit chli
H8Z74_20070	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H8Z74_20135	COG1090	epimerase
H8Z74_20145	COG0642	Histidine kinase
H8Z74_20170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8Z74_20195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8Z74_20200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8Z74_20215	COG0753	catalase activity
H8Z74_20230	COG2197	response regulator
H8Z74_20235	COG4585	Histidine kinase
H8Z74_20240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z74_20245	COG1136	(ABC) transporter
H8Z74_20270	COG0697	spore germination
H8Z74_20285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z74_20290	COG0180	Tryptophanyl-tRNA synthetase
H8Z74_20295	COG3237	CsbD-like
H8Z74_20335	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H8Z74_20350	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H8Z74_20395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8Z74_20415	COG1199	ATP-dependent helicase activity
H8Z74_20430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8Z74_20495	COG0625	glutathione transferase activity
H8Z74_20530	COG4555	ABC transporter
H8Z74_20540	COG1476	TRANSCRIPTIONal
H8Z74_20585	COG0543	2 iron, 2 sulfur cluster binding
H8Z74_20585	COG0633	Ferredoxin
H8Z74_20590	COG1131	(ABC) transporter
H8Z74_20595	COG0842	Transport permease protein
H8Z74_20605	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H8Z74_20640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8Z74_20645	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8Z74_20655	COG1042	CoA-binding domain protein
H8Z74_20655	COG0045	succinate-CoA ligase (ADP-forming) activity
H8Z74_20655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8Z74_20660	COG2239	Acts as a magnesium transporter
H8Z74_20675	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8Z74_20680	COG3387	PFAM Glycoside hydrolase 15-related
H8Z74_20695	COG3100	YcgL domain-containing protein
H8Z74_20700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8Z74_20710	COG0463	Glycosyl transferase, family 2
H8Z74_20730	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z74_20765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z74_20780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8Z74_20805	COG1506	peptidase
H8Z74_20805	COG0823	Involved in the tonB-independent uptake of proteins
H8Z74_20805	COG4946	Tricorn protease homolog
H8Z74_20820	COG0408	coproporphyrinogen oxidase activity
H8Z74_20855	COG2815	serine threonine protein kinase
H8Z74_20855	COG0515	serine threonine protein kinase
H8Z74_20860	COG0631	protein serine/threonine phosphatase activity
H8Z74_21045	COG0210	DNA helicase
H8Z74_21055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z74_21060	COG0583	DNA-binding transcription factor activity
H8Z74_21065	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H8Z74_21075	COG2159	amidohydrolase
H8Z74_21095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z74_21115	COG0357	Ribosomal RNA small subunit methyltransferase G
H8Z74_21120	COG3540	Alkaline phosphatase
H8Z74_21130	COG2091	lysine biosynthetic process via aminoadipic acid
H8Z74_21145	COG0708	Exodeoxyribonuclease III
H8Z74_21150	COG1940	carbohydrate kinase activity
H8Z74_21150	COG1846	Transcriptional regulator
H8Z74_21160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z74_21170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8Z74_21175	COG3162	membrane
H8Z74_21185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8Z74_21210	COG3507	Belongs to the glycosyl hydrolase 43 family
H8Z74_21230	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z74_21235	COG0179	Fumarylacetoacetate (FAA) hydrolase
H8Z74_21240	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z74_21245	COG3254	rhamnose metabolic process
H8Z74_21250	COG0738	Major facilitator superfamily
H8Z74_21255	COG1414	Transcriptional regulator
H8Z74_21260	COG1971	Probably functions as a manganese efflux pump
H8Z74_21265	COG2205	protein histidine kinase activity
H8Z74_21275	COG3459	Glycosyltransferase 36 associated
H8Z74_21280	COG2211	Major facilitator Superfamily
H8Z74_21285	COG3265	gluconokinase activity
H8Z74_21290	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z74_21310	COG2911	Protein conserved in bacteria
H8Z74_21315	COG0729	surface antigen
H8Z74_21340	COG0752	glycyl-tRNA synthetase alpha subunit
H8Z74_21345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z74_21355	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z74_21355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8Z74_21365	COG0805	protein transport
H8Z74_21370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8Z74_21375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8Z74_21385	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8Z74_21405	COG2974	May be involved in recombination
H8Z74_21410	COG0037	tRNA processing
H8Z74_21415	COG2115	Belongs to the xylose isomerase family
H8Z74_21425	COG3661	Belongs to the glycosyl hydrolase 67 family
H8Z74_21435	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z74_21445	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z74_21450	COG0246	Mannitol dehydrogenase
H8Z74_21495	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8Z74_21525	COG3386	PFAM SMP-30 Gluconolaconase
H8Z74_21535	COG3250	beta-galactosidase activity
H8Z74_21540	COG1904	glucuronate isomerase
H8Z74_21560	COG3693	PFAM glycoside hydrolase, family 10
H8Z74_21575	COG2211	Major facilitator Superfamily
H8Z74_21655	COG2937	Belongs to the GPAT DAPAT family
H8Z74_21685	COG0284	orotidine-5'-phosphate decarboxylase activity
H8Z74_21690	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H8Z74_21695	COG3132	Protein of unknown function, DUF480
H8Z74_21710	COG0210	DNA helicase
H8Z74_21715	COG1435	thymidine kinase activity
H8Z74_21725	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H8Z74_21735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H8Z74_21765	COG3135	benzoate transporter
H8Z74_21800	COG3012	SEC-C Motif Domain Protein
H8Z74_21805	COG0730	response to heat
H8Z74_21825	COG0302	gtp cyclohydrolase
H8Z74_21840	COG1566	PFAM secretion protein HlyD family protein
H8Z74_21850	COG1289	transmembrane transporter activity
H8Z74_21855	COG0477	Major facilitator Superfamily
H8Z74_21865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z74_21885	COG4691	Plasmid stability protein
H8Z74_21890	COG1487	ribonuclease activity
H8Z74_21925	COG0564	pseudouridine synthase activity
H8Z74_21980	COG1074	ATP-dependent DNA helicase activity
H8Z74_21985	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H8Z74_22000	COG1127	ABC transporter
H8Z74_22005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8Z74_22010	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8Z74_22025	COG2853	Lipoprotein
H8Z74_22035	COG0386	Belongs to the glutathione peroxidase family
H8Z74_22045	COG1322	Protein conserved in bacteria
H8Z74_22050	COG0604	alcohol dehydrogenase
H8Z74_22065	COG0625	glutathione transferase activity
H8Z74_22075	COG0531	amino acid
H8Z74_22080	COG3537	Alpha-1,2-mannosidase
H8Z74_22090	COG3706	GGDEF domain
H8Z74_22095	COG3835	regulator
H8Z74_22100	COG1929	Belongs to the glycerate kinase type-1 family
H8Z74_22105	COG2271	Major facilitator Superfamily
H8Z74_22120	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H8Z74_22125	COG0861	Integral membrane protein TerC family
H8Z74_22135	COG0584	glycerophosphoryl diester phosphodiesterase
H8Z74_22150	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H8Z74_22155	COG0726	polysaccharide deacetylase
H8Z74_22160	COG0706	membrane insertase activity
H8Z74_22165	COG0594	ribonuclease P activity
H8Z74_22210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z74_22255	COG4680	protein conserved in bacteria
H8Z74_22290	COG0489	protein tyrosine kinase activity
H8Z74_22355	COG4962	Type ii secretion system protein e
H8Z74_22360	COG3838	Conjugal transfer protein Trbc
H8Z74_22370	COG3451	type IV secretory pathway VirB4
H8Z74_22395	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z74_22415	COG3012	SEC-C Motif Domain Protein
H8Z74_22415	COG3318	Belongs to the UPF0149 family
H8Z74_22425	COG1487	ribonuclease activity
H8Z74_22440	COG3505	Type IV secretory pathway VirD4
H8Z74_22480	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z74_22505	COG3012	SEC-C Motif Domain Protein
H8Z74_22505	COG3318	Belongs to the UPF0149 family
H8Z74_22525	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z74_22565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8Z74_22610	COG0741	lytic transglycosylase activity
H8Z74_22705	COG1475	DNA binding
H8Z74_22745	COG0629	single-stranded DNA binding
H8Z74_22780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8Z74_23005	COG4644	lycopene metabolic process
H8Z74_23055	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8Z74_23080	COG2132	Multicopper oxidase
H8Z74_23115	COG0010	Belongs to the arginase family
H8Z74_23120	COG2986	histidine ammonia-lyase
H8Z74_23125	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H8Z74_23130	COG2188	Transcriptional regulator
H8Z74_23150	COG2871	sodium ion transport
H8Z74_23175	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z74_23180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z74_23195	COG2217	Heavy metal translocating P-type atpase
H8Z74_23200	COG2217	Heavy metal translocating P-type atpase
H8Z74_23210	COG1063	alcohol dehydrogenase
H8Z74_23400	COG1192	Involved in chromosome partitioning
H8Z74_23570	COG3550	peptidyl-serine autophosphorylation
H8Z74_23690	COG1192	Involved in chromosome partitioning
H8Z74_23785	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z74_23805	COG3012	SEC-C Motif Domain Protein
H8Z74_23805	COG3318	Belongs to the UPF0149 family
H8Z74_23925	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z74_23945	COG3318	Belongs to the UPF0149 family
H8Z74_23945	COG3012	SEC-C Motif Domain Protein
H8Z74_23970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z74_23975	COG4456	Virulence-associated protein