locus-tag	class	description
H8Z75_00020	COG3179	chitinase
H8Z75_00065	COG4695	Portal protein
H8Z75_00150	COG0556	nucleotide-excision repair
H8Z75_00165	COG3505	Type IV secretory pathway VirD4
H8Z75_00185	COG2948	multi-organism process
H8Z75_00310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H8Z75_00315	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H8Z75_00330	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H8Z75_00335	COG0072	phenylalanine-tRNA ligase activity
H8Z75_00335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8Z75_00385	COG0438	transferase activity, transferring glycosyl groups
H8Z75_00390	COG0438	transferase activity, transferring glycosyl groups
H8Z75_00400	COG0438	transferase activity, transferring glycosyl groups
H8Z75_00425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z75_00430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z75_00435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z75_00465	COG1960	acyl-CoA dehydrogenase activity
H8Z75_00480	COG3040	lipid binding
H8Z75_00495	COG0322	excinuclease ABC activity
H8Z75_00510	COG0784	Response regulator, receiver
H8Z75_00510	COG4191	Histidine kinase
H8Z75_00515	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H8Z75_00520	COG1194	a g-specific adenine glycosylase
H8Z75_00535	COG3938	Belongs to the proline racemase family
H8Z75_00555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8Z75_00565	COG0006	proline dipeptidase activity
H8Z75_00580	COG0531	amino acid
H8Z75_00675	COG0326	Molecular chaperone. Has ATPase activity
H8Z75_00680	COG0742	ribosomal rna small subunit methyltransferase
H8Z75_00685	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H8Z75_00695	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8Z75_00710	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H8Z75_00745	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H8Z75_00750	COG0343	queuine tRNA-ribosyltransferase activity
H8Z75_00755	COG1862	Preprotein translocase
H8Z75_00765	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8Z75_00810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8Z75_00810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8Z75_00815	COG1105	Belongs to the carbohydrate kinase PfkB family
H8Z75_00820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z75_00820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8Z75_00825	COG1609	Transcriptional regulator
H8Z75_00830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z75_00835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z75_00845	COG2902	Dehydrogenase
H8Z75_00855	COG0477	Major facilitator Superfamily
H8Z75_00865	COG2205	protein histidine kinase activity
H8Z75_00865	COG0784	Response regulator, receiver
H8Z75_00865	COG5002	protein histidine kinase activity
H8Z75_00870	COG2733	membrane
H8Z75_00890	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H8Z75_00910	COG2703	oxygen carrier activity
H8Z75_00920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z75_00925	COG0174	glutamine synthetase
H8Z75_00930	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H8Z75_00945	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H8Z75_00965	COG3842	ATPase activity
H8Z75_00995	COG4535	Mg2 and Co2 transporter CorC
H8Z75_01005	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H8Z75_01020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8Z75_01035	COG0741	lytic transglycosylase activity
H8Z75_01040	COG0723	plastoquinol--plastocyanin reductase activity
H8Z75_01045	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8Z75_01050	COG2857	Cytochrome c1
H8Z75_01055	COG0625	glutathione transferase activity
H8Z75_01085	COG2094	Belongs to the DNA glycosylase MPG family
H8Z75_01095	COG0835	chemotaxis
H8Z75_01295	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8Z75_01305	COG1570	exodeoxyribonuclease VII activity
H8Z75_01310	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8Z75_01315	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8Z75_01315	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H8Z75_01325	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8Z75_01355	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z75_01365	COG0501	Belongs to the peptidase M48B family
H8Z75_01375	COG2081	HI0933 family
H8Z75_01380	COG4681	YaeQ
H8Z75_01390	COG0625	glutathione transferase activity
H8Z75_01410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8Z75_01415	COG0513	Belongs to the DEAD box helicase family
H8Z75_01420	COG0488	(ABC) transporter
H8Z75_01435	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8Z75_01440	COG0483	inositol monophosphate 1-phosphatase activity
H8Z75_01455	COG5001	Diguanylate cyclase
H8Z75_01455	COG3300	MHYT domain
H8Z75_01460	COG1509	lysine 2,3-aminomutase activity
H8Z75_01465	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8Z75_01475	COG0402	S-adenosylhomocysteine deaminase activity
H8Z75_01480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8Z75_01535	COG4302	ethanolamine ammonia-lyase activity
H8Z75_01565	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H8Z75_01570	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H8Z75_01585	COG2166	iron-sulfur cluster assembly
H8Z75_01590	COG0215	cysteine-tRNA ligase activity
H8Z75_01600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H8Z75_01615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z75_01620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H8Z75_01630	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H8Z75_01635	COG0165	Argininosuccinate lyase
H8Z75_01645	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H8Z75_01655	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H8Z75_01680	COG1294	oxidase, subunit
H8Z75_01695	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H8Z75_01700	COG1278	Cold shock
H8Z75_01705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z75_01725	COG1138	Cytochrome C-type biogenesis protein
H8Z75_01730	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H8Z75_01750	COG4133	protoheme IX ABC transporter activity
H8Z75_01755	COG0436	Aminotransferase
H8Z75_01780	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H8Z75_01785	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H8Z75_01790	COG2350	Protein conserved in bacteria
H8Z75_01820	COG1175	transmembrane transport
H8Z75_01825	COG0395	ABC-type sugar transport system, permease component
H8Z75_01850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8Z75_01855	COG2957	Belongs to the agmatine deiminase family
H8Z75_01870	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H8Z75_01875	COG0539	negative regulation of cytoplasmic translation
H8Z75_01880	COG0776	regulation of translation
H8Z75_01890	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H8Z75_01895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8Z75_01905	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H8Z75_01910	COG0475	glutathione-regulated potassium exporter activity
H8Z75_01910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8Z75_01930	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8Z75_01930	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z75_01970	COG2003	Belongs to the UPF0758 family
H8Z75_01990	COG2084	Dehydrogenase
H8Z75_02290	COG0270	DNA (cytosine-5-)-methyltransferase activity
H8Z75_02295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z75_02300	COG0629	single-stranded DNA binding
H8Z75_02445	COG0582	viral genome integration into host DNA
H8Z75_02455	COG1396	sequence-specific DNA binding
H8Z75_02480	COG1538	Outer membrane efflux protein
H8Z75_02495	COG1309	transcriptional regulator
H8Z75_02535	COG1396	sequence-specific DNA binding
H8Z75_02540	COG0583	DNA-binding transcription factor activity
H8Z75_02555	COG2086	electron transfer activity
H8Z75_02560	COG1063	alcohol dehydrogenase
H8Z75_02565	COG0318	PFAM AMP-dependent synthetase and ligase
H8Z75_02575	COG1024	Enoyl-CoA hydratase
H8Z75_02580	COG1960	acyl-CoA dehydrogenase activity
H8Z75_02585	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8Z75_02590	COG3246	L-lysine catabolic process to acetate
H8Z75_02625	COG0066	3-isopropylmalate dehydratase activity
H8Z75_02630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H8Z75_02635	COG2271	Major facilitator Superfamily
H8Z75_02645	COG1063	alcohol dehydrogenase
H8Z75_02705	COG2207	Transcriptional regulator
H8Z75_02710	COG2807	transmembrane transport
H8Z75_02725	COG3938	Belongs to the proline racemase family
H8Z75_02735	COG2249	NAD(P)H dehydrogenase (quinone) activity
H8Z75_02750	COG5006	permease, DMT superfamily
H8Z75_02810	COG0270	DNA (cytosine-5-)-methyltransferase activity
H8Z75_02865	COG2274	protein secretion by the type I secretion system
H8Z75_02930	COG2336	PFAM SpoVT AbrB
H8Z75_02955	COG0582	viral genome integration into host DNA
H8Z75_02985	COG2003	Belongs to the UPF0758 family
H8Z75_03000	COG1396	sequence-specific DNA binding
H8Z75_03030	COG1073	alpha beta
H8Z75_03030	COG2226	methyltransferase
H8Z75_03075	COG0316	Belongs to the HesB IscA family
H8Z75_03075	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H8Z75_03080	COG2154	pterin-4-alpha-carbinolamine dehydratase
H8Z75_03090	COG0428	transporter
H8Z75_03095	COG3064	Membrane
H8Z75_03100	COG0564	pseudouridine synthase activity
H8Z75_03115	COG1054	Belongs to the UPF0176 family
H8Z75_03135	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H8Z75_03145	COG0582	viral genome integration into host DNA
H8Z75_03220	COG0629	single-stranded DNA binding
H8Z75_03325	COG3344	reverse transcriptase
H8Z75_03420	COG2003	Belongs to the UPF0758 family
H8Z75_03520	COG0583	DNA-binding transcription factor activity
H8Z75_03525	COG1396	sequence-specific DNA binding
H8Z75_03535	COG0582	viral genome integration into host DNA
H8Z75_03545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8Z75_03550	COG0322	excinuclease ABC activity
H8Z75_03560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8Z75_03565	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H8Z75_03570	COG1663	tetraacyldisaccharide 4'-kinase activity
H8Z75_03575	COG1132	(ABC) transporter
H8Z75_03585	COG0811	peptide transport
H8Z75_03600	COG1136	(ABC) transporter
H8Z75_03605	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8Z75_03615	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H8Z75_03620	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H8Z75_03635	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H8Z75_03665	COG0837	glucose binding
H8Z75_03670	COG0363	glucosamine-6-phosphate deaminase activity
H8Z75_03675	COG0129	dihydroxy-acid dehydratase activity
H8Z75_03680	COG0800	Aldolase
H8Z75_03755	COG2183	response to ionizing radiation
H8Z75_03765	COG0723	plastoquinol--plastocyanin reductase activity
H8Z75_03765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z75_03780	COG3243	poly(R)-hydroxyalkanoic acid synthase
H8Z75_03790	COG1183	phosphatidylcholine synthase activity
H8Z75_03795	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z75_03810	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H8Z75_03820	COG0668	transmembrane transport
H8Z75_03825	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H8Z75_03840	COG1914	H( )-stimulated, divalent metal cation uptake system
H8Z75_03855	COG0746	molybdenum cofactor guanylyltransferase activity
H8Z75_03860	COG0303	'Molybdopterin
H8Z75_03870	COG0708	Exodeoxyribonuclease III
H8Z75_03905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H8Z75_03910	COG0303	'Molybdopterin
H8Z75_03920	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z75_03930	COG1426	Protein conserved in bacteria
H8Z75_03940	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H8Z75_03955	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8Z75_03955	COG1024	Enoyl-CoA hydratase
H8Z75_03960	COG0183	Belongs to the thiolase family
H8Z75_03970	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H8Z75_03980	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H8Z75_03995	COG0492	ferredoxin-NADP+ reductase activity
H8Z75_04035	COG2915	High frequency lysogenization protein hflD homolog
H8Z75_04065	COG5002	protein histidine kinase activity
H8Z75_04085	COG0835	chemotaxis
H8Z75_04085	COG0784	Response regulator, receiver
H8Z75_04095	COG1558	bacterial-type flagellum-dependent cell motility
H8Z75_04100	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H8Z75_04110	COG4787	bacterial-type flagellum-dependent cell motility
H8Z75_04125	COG1706	bacterial-type flagellum-dependent cell motility
H8Z75_04130	COG1705	Flagellar rod assembly protein muramidase FlgJ
H8Z75_04130	COG3951	Flagellar rod assembly protein muramidase FlgJ
H8Z75_04155	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H8Z75_04185	COG2201	protein-glutamate methylesterase activity
H8Z75_04205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z75_04210	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z75_04215	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z75_04245	COG1677	Flagellar hook-basal body complex protein FliE
H8Z75_04310	COG1684	flagellar biosynthetic protein fliR
H8Z75_04480	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H8Z75_04485	COG1360	Flagellar Motor Protein
H8Z75_04495	COG0835	chemotaxis
H8Z75_04505	COG0745	RESPONSE REGULATOR receiver
H8Z75_04515	COG0840	transmembrane signaling receptor activity
H8Z75_04545	COG0840	transmembrane signaling receptor activity
H8Z75_04550	COG0840	transmembrane signaling receptor activity
H8Z75_04560	COG0840	transmembrane signaling receptor activity
H8Z75_04565	COG0840	transmembrane signaling receptor activity
H8Z75_04570	COG0840	transmembrane signaling receptor activity
H8Z75_04575	COG0840	transmembrane signaling receptor activity
H8Z75_04590	COG0835	chemotaxis
H8Z75_04600	COG0840	transmembrane signaling receptor activity
H8Z75_04610	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H8Z75_04615	COG2201	protein-glutamate methylesterase activity
H8Z75_04625	COG2267	carboxylic ester hydrolase activity
H8Z75_04660	COG1024	Enoyl-CoA hydratase
H8Z75_04665	COG2198	Histidine kinase
H8Z75_04665	COG2205	protein histidine kinase activity
H8Z75_04665	COG0784	Response regulator, receiver
H8Z75_04675	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8Z75_04685	COG3279	Response regulator of the LytR AlgR family
H8Z75_04725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H8Z75_04735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z75_04755	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H8Z75_04760	COG2258	MOSC domain
H8Z75_04810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8Z75_04830	COG0277	FAD linked oxidase domain protein
H8Z75_04835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8Z75_04845	COG0531	amino acid
H8Z75_04855	COG0235	Class ii aldolase
H8Z75_04865	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H8Z75_04880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H8Z75_04880	COG0140	phosphoribosyl-ATP diphosphatase activity
H8Z75_04885	COG0107	imidazoleglycerol-phosphate synthase activity
H8Z75_04890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H8Z75_04895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H8Z75_04910	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H8Z75_04915	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H8Z75_04925	COG0124	histidyl-tRNA synthetase
H8Z75_04930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z75_05020	COG1649	PFAM Uncharacterised BCR, COG1649
H8Z75_05020	COG0726	polysaccharide deacetylase
H8Z75_05025	COG1215	transferase activity, transferring glycosyl groups
H8Z75_05040	COG1012	belongs to the aldehyde dehydrogenase family
H8Z75_05055	COG0167	dihydroorotate dehydrogenase activity
H8Z75_05060	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H8Z75_05065	COG0697	spore germination
H8Z75_05070	COG1794	racemase activity, acting on amino acids and derivatives
H8Z75_05085	COG0671	phosphoesterase, PA-phosphatase related
H8Z75_05090	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H8Z75_05100	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H8Z75_05105	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z75_05115	COG5001	Diguanylate cyclase
H8Z75_05115	COG2203	Gaf domain
H8Z75_05115	COG3706	GGDEF domain
H8Z75_05115	COG4251	negative regulation of phosphorylation
H8Z75_05125	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z75_05150	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H8Z75_05155	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H8Z75_05160	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H8Z75_05180	COG1469	GTP cyclohydrolase I activity
H8Z75_05185	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8Z75_05210	COG2115	Belongs to the xylose isomerase family
H8Z75_05215	COG1070	Carbohydrate kinase
H8Z75_05225	COG1501	Belongs to the glycosyl hydrolase 31 family
H8Z75_05260	COG0800	Aldolase
H8Z75_05265	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z75_05275	COG3734	2-keto-3-deoxy-galactonokinase
H8Z75_05280	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H8Z75_05290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8Z75_05305	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8Z75_05310	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H8Z75_05325	COG0351	phosphomethylpyrimidine kinase
H8Z75_05325	COG0352	thiamine-phosphate diphosphorylase activity
H8Z75_05355	COG1741	Belongs to the pirin family
H8Z75_05370	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H8Z75_05375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H8Z75_05380	COG2137	regulation of response to DNA damage stimulus
H8Z75_05385	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H8Z75_05390	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8Z75_05400	COG1546	Belongs to the CinA family
H8Z75_05405	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H8Z75_05415	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8Z75_05420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8Z75_05430	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H8Z75_05435	COG1534	Rna-binding protein
H8Z75_05450	COG1238	metal cluster binding
H8Z75_05455	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H8Z75_05460	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H8Z75_05465	COG2840	Smr protein MutS2
H8Z75_05475	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H8Z75_05485	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H8Z75_05500	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H8Z75_05505	COG0504	CTP synthase activity
H8Z75_05530	COG0306	phosphate transporter
H8Z75_05540	COG1253	flavin adenine dinucleotide binding
H8Z75_05555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z75_05560	COG0477	Major facilitator Superfamily
H8Z75_05570	COG1136	(ABC) transporter
H8Z75_05595	COG2264	protein methyltransferase activity
H8Z75_05625	COG2244	polysaccharide biosynthetic process
H8Z75_05690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8Z75_05700	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H8Z75_05710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z75_05725	COG0784	Response regulator, receiver
H8Z75_05725	COG4191	Histidine kinase
H8Z75_05730	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H8Z75_05755	COG0840	transmembrane signaling receptor activity
H8Z75_05815	COG0583	DNA-binding transcription factor activity
H8Z75_05820	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8Z75_05850	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H8Z75_05860	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H8Z75_05905	COG1228	amidohydrolase
H8Z75_05910	COG2986	histidine ammonia-lyase
H8Z75_05930	COG4993	Dehydrogenase
H8Z75_05940	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H8Z75_05955	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H8Z75_05960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8Z75_05965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8Z75_05985	COG0359	binds to the 23S rRNA
H8Z75_05990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H8Z75_05995	COG0360	Binds together with S18 to 16S ribosomal RNA
H8Z75_06025	COG2808	Putative FMN-binding domain
H8Z75_06110	COG0662	Cupin 2, conserved barrel domain protein
H8Z75_06125	COG3844	kynureninase activity
H8Z75_06130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z75_06140	COG2925	Exonuclease
H8Z75_06165	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8Z75_06170	COG0116	Belongs to the methyltransferase superfamily
H8Z75_06170	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H8Z75_06180	COG0488	(ABC) transporter
H8Z75_06215	COG0494	nUDIX hydrolase
H8Z75_06225	COG1024	Enoyl-CoA hydratase
H8Z75_06235	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H8Z75_06265	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8Z75_06270	COG0573	inorganic phosphate transmembrane transporter activity
H8Z75_06275	COG0581	inorganic phosphate transmembrane transporter activity
H8Z75_06280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8Z75_06285	COG0704	Plays a role in the regulation of phosphate uptake
H8Z75_06295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8Z75_06305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8Z75_06330	COG1960	acyl-CoA dehydrogenase activity
H8Z75_06335	COG1960	acyl-CoA dehydrogenase activity
H8Z75_06340	COG1960	acyl-CoA dehydrogenase activity
H8Z75_06345	COG1960	acyl-CoA dehydrogenase activity
H8Z75_06350	COG2226	methyltransferase
H8Z75_06355	COG0646	methionine synthase
H8Z75_06355	COG1410	methionine synthase
H8Z75_06360	COG1410	methionine synthase
H8Z75_06360	COG0646	methionine synthase
H8Z75_06370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z75_06410	COG0386	Belongs to the glutathione peroxidase family
H8Z75_06420	COG1725	Transcriptional regulator
H8Z75_06425	COG1131	(ABC) transporter
H8Z75_06455	COG1253	flavin adenine dinucleotide binding
H8Z75_06475	COG2850	peptidyl-arginine hydroxylation
H8Z75_06510	COG1132	(ABC) transporter
H8Z75_06515	COG0583	DNA-binding transcription factor activity
H8Z75_06545	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H8Z75_06555	COG0484	heat shock protein binding
H8Z75_06565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H8Z75_06570	COG1420	regulation of RNA biosynthetic process
H8Z75_06575	COG0497	DNA recombination
H8Z75_06585	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z75_06600	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H8Z75_06625	COG3706	GGDEF domain
H8Z75_06670	COG0583	DNA-binding transcription factor activity
H8Z75_06680	COG0415	Belongs to the DNA photolyase family
H8Z75_06685	COG0305	Participates in initiation and elongation during chromosome replication
H8Z75_06695	COG0367	asparagine synthase
H8Z75_06710	COG1960	acyl-CoA dehydrogenase activity
H8Z75_06725	COG0084	hydrolase, TatD family'
H8Z75_06785	COG0386	Belongs to the glutathione peroxidase family
H8Z75_06790	COG0339	signal peptide processing
H8Z75_06840	COG2814	Major facilitator Superfamily
H8Z75_06845	COG1566	PFAM secretion protein HlyD family protein
H8Z75_06875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8Z75_06900	COG0367	asparagine synthase
H8Z75_06905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z75_06910	COG1393	Belongs to the ArsC family
H8Z75_06965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H8Z75_06975	COG0528	UMP kinase activity
H8Z75_06980	COG0233	cytoplasmic translational termination
H8Z75_06985	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H8Z75_06995	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H8Z75_07005	COG0750	zinc metalloprotease
H8Z75_07020	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z75_07025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z75_07030	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z75_07040	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H8Z75_07050	COG0825	malonyl-CoA metabolic process
H8Z75_07065	COG1981	membrane
H8Z75_07085	COG1695	Transcriptional regulator
H8Z75_07105	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8Z75_07115	COG2040	homocysteine
H8Z75_07120	COG0833	amino acid
H8Z75_07125	COG0346	lactoylglutathione lyase activity
H8Z75_07130	COG1131	(ABC) transporter
H8Z75_07155	COG2878	Part of a membrane complex involved in electron transport
H8Z75_07170	COG1595	DNA-templated transcription, initiation
H8Z75_07195	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H8Z75_07210	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H8Z75_07215	COG0251	oxidation-reduction process
H8Z75_07225	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H8Z75_07225	COG0392	lysyltransferase activity
H8Z75_07265	COG1902	pentaerythritol trinitrate reductase activity
H8Z75_07270	COG2824	Alkylphosphonate utilization operon protein PhnA
H8Z75_07280	COG1047	Peptidyl-prolyl cis-trans
H8Z75_07285	COG1077	Cell shape determining protein MreB Mrl
H8Z75_07300	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H8Z75_07310	COG5487	UPF0391 membrane protein
H8Z75_07315	COG1451	nucleotide metabolic process
H8Z75_07340	COG0183	Belongs to the thiolase family
H8Z75_07370	COG1793	dna ligase
H8Z75_07370	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8Z75_07385	COG1201	RNA secondary structure unwinding
H8Z75_07400	COG1278	Cold shock
H8Z75_07405	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H8Z75_07410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H8Z75_07415	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z75_07425	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
H8Z75_07430	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H8Z75_07435	COG2954	triphosphatase activity
H8Z75_07450	COG1381	Involved in DNA repair and RecF pathway recombination
H8Z75_07455	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H8Z75_07460	COG0571	ribonuclease III activity
H8Z75_07475	COG0481	GTPase activity
H8Z75_07480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8Z75_07495	COG1024	Enoyl-CoA hydratase
H8Z75_07495	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8Z75_07515	COG1024	Enoyl-CoA hydratase
H8Z75_07520	COG1960	acyl-CoA dehydrogenase activity
H8Z75_07545	COG3250	beta-galactosidase activity
H8Z75_07570	COG3209	COG3209 Rhs family protein
H8Z75_07590	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H8Z75_07610	COG0534	Mate efflux family protein
H8Z75_07615	COG0335	large ribosomal subunit rRNA binding
H8Z75_07620	COG0336	Belongs to the RNA methyltransferase TrmD family
H8Z75_07625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H8Z75_07630	COG0228	four-way junction DNA binding
H8Z75_07635	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8Z75_07645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H8Z75_07650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8Z75_07680	COG4191	Histidine kinase
H8Z75_07680	COG0784	Response regulator, receiver
H8Z75_07685	COG3437	response regulator, receiver
H8Z75_07685	COG4999	Histidine kinase
H8Z75_07685	COG3850	Histidine kinase
H8Z75_07685	COG2205	protein histidine kinase activity
H8Z75_07690	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8Z75_07700	COG2205	protein histidine kinase activity
H8Z75_07705	COG5507	3-demethylubiquinone-9 3-methyltransferase
H8Z75_07715	COG4771	TonB-dependent receptor
H8Z75_07740	COG2172	sigma factor antagonist activity
H8Z75_07745	COG1366	Belongs to the anti-sigma-factor antagonist family
H8Z75_07750	COG1366	Belongs to the anti-sigma-factor antagonist family
H8Z75_07760	COG0326	Molecular chaperone. Has ATPase activity
H8Z75_07765	COG2207	Transcriptional regulator
H8Z75_07775	COG3152	Membrane
H8Z75_07790	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H8Z75_07795	COG1845	cytochrome c oxidase, subunit III
H8Z75_07800	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H8Z75_07815	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H8Z75_07820	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H8Z75_07825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H8Z75_07830	COG0196	riboflavin kinase activity
H8Z75_07840	COG0268	Binds directly to 16S ribosomal RNA
H8Z75_07845	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H8Z75_07850	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H8Z75_07855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H8Z75_07860	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H8Z75_07865	COG0824	Thioesterase
H8Z75_07880	COG1946	Acyl-CoA thioesterase
H8Z75_07900	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H8Z75_07910	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H8Z75_07935	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H8Z75_07950	COG2197	response regulator
H8Z75_07955	COG4585	Histidine kinase
H8Z75_07965	COG0850	regulation of cytokinetic process
H8Z75_07970	COG2894	cell division
H8Z75_07975	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H8Z75_07985	COG0642	Histidine kinase
H8Z75_07990	COG0745	RESPONSE REGULATOR receiver
H8Z75_08005	COG2194	sulfuric ester hydrolase activity
H8Z75_08020	COG2814	Major facilitator Superfamily
H8Z75_08025	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8Z75_08025	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8Z75_08035	COG0656	L-ascorbic acid biosynthetic process
H8Z75_08040	COG0753	catalase activity
H8Z75_08055	COG2207	Transcriptional regulator
H8Z75_08055	COG1917	Cupin 2, conserved barrel domain protein
H8Z75_08070	COG0823	Involved in the tonB-independent uptake of proteins
H8Z75_08070	COG1506	peptidase
H8Z75_08085	COG1297	OPT oligopeptide transporter protein
H8Z75_08120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8Z75_08155	COG2080	2 iron, 2 sulfur cluster binding
H8Z75_08160	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8Z75_08190	COG0492	ferredoxin-NADP+ reductase activity
H8Z75_08210	COG3537	Alpha-1,2-mannosidase
H8Z75_08215	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z75_08220	COG3387	PFAM Glycoside hydrolase 15-related
H8Z75_08230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8Z75_08305	COG1309	transcriptional regulator
H8Z75_08310	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z75_08320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H8Z75_08330	COG0330	HflC and HflK could
H8Z75_08335	COG0330	HflC and HflK could
H8Z75_08355	COG0678	peroxiredoxin activity
H8Z75_08375	COG4953	penicillin-binding protein 1C
H8Z75_08415	COG3609	addiction module antidote protein, CC2985 family
H8Z75_08435	COG3829	transcription factor binding
H8Z75_08460	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H8Z75_08465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H8Z75_08480	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z75_08495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z75_08500	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H8Z75_08505	COG1399	metal-binding, possibly nucleic acid-binding protein
H8Z75_08510	COG0424	maF-like protein
H8Z75_08530	COG0714	Associated with various cellular activities
H8Z75_08550	COG0537	adenosine 5'-monophosphoramidase activity
H8Z75_08555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H8Z75_08560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H8Z75_08605	COG0210	DNA helicase
H8Z75_08770	COG0314	molybdopterin synthase activity
H8Z75_08775	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H8Z75_08780	COG0315	cyclic pyranopterin monophosphate synthase activity
H8Z75_08790	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H8Z75_08795	COG1234	tRNA 3'-trailer cleavage
H8Z75_08800	COG3642	lipopolysaccharide core region biosynthetic process
H8Z75_08805	COG0859	PFAM glycosyl transferase family 9
H8Z75_08820	COG0631	protein serine/threonine phosphatase activity
H8Z75_08825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8Z75_08830	COG0328	RNA-DNA hybrid ribonuclease activity
H8Z75_08840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z75_08850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z75_08880	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H8Z75_08890	COG0544	peptidyl-prolyl cis-trans isomerase activity
H8Z75_09055	COG0473	3-isopropylmalate dehydrogenase activity
H8Z75_09085	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H8Z75_09100	COG0671	phosphoesterase, PA-phosphatase related
H8Z75_09105	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8Z75_09115	COG3291	Pkd domain containing protein
H8Z75_09125	COG2833	Protein of unknown function (DUF455)
H8Z75_09145	COG0285	dihydrofolate synthase activity
H8Z75_09150	COG0406	alpha-ribazole phosphatase activity
H8Z75_09180	COG1063	alcohol dehydrogenase
H8Z75_09190	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H8Z75_09195	COG4208	sulfate ABC transporter
H8Z75_09205	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H8Z75_09210	COG0156	8-amino-7-oxononanoate synthase activity
H8Z75_09235	COG0604	alcohol dehydrogenase
H8Z75_09240	COG0446	pyridine nucleotide-disulphide oxidoreductase
H8Z75_09240	COG1902	pentaerythritol trinitrate reductase activity
H8Z75_09250	COG0625	glutathione transferase activity
H8Z75_09260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8Z75_09265	COG1217	gtp-binding protein TYPA
H8Z75_09275	COG0154	amidase activity
H8Z75_09285	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H8Z75_09300	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H8Z75_09305	COG0203	ribosomal protein L17
H8Z75_09330	COG0201	protein transport
H8Z75_09335	COG0200	Binds to the 23S rRNA
H8Z75_09340	COG1841	ribosomal large subunit assembly
H8Z75_09350	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H8Z75_09355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H8Z75_09360	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H8Z75_09370	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H8Z75_09375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H8Z75_09385	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H8Z75_09390	COG0255	Belongs to the universal ribosomal protein uL29 family
H8Z75_09395	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H8Z75_09400	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H8Z75_09410	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H8Z75_09415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H8Z75_09420	COG0089	rRNA binding
H8Z75_09425	COG0088	Forms part of the polypeptide exit tunnel
H8Z75_09430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H8Z75_09435	COG0051	transcription antitermination factor activity, RNA binding
H8Z75_09440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8Z75_09445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H8Z75_09450	COG0049	tRNA binding
H8Z75_09455	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H8Z75_09460	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8Z75_09465	COG0085	RNA polymerase activity
H8Z75_09470	COG0222	ribosome binding
H8Z75_09475	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H8Z75_09480	COG0081	regulation of translation
H8Z75_09485	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H8Z75_09490	COG0250	Participates in transcription elongation, termination and antitermination
H8Z75_09505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8Z75_09525	COG0012	GTP binding
H8Z75_09530	COG0193	aminoacyl-tRNA hydrolase activity
H8Z75_09535	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H8Z75_09540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H8Z75_09550	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H8Z75_09555	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H8Z75_09565	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H8Z75_09570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H8Z75_09580	COG0521	Mo-molybdopterin cofactor biosynthetic process
H8Z75_09595	COG1254	Belongs to the acylphosphatase family
H8Z75_09600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z75_09605	COG1295	ribonuclease BN
H8Z75_09630	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H8Z75_09635	COG1404	Belongs to the peptidase S8 family
H8Z75_09640	COG1404	Belongs to the peptidase S8 family
H8Z75_09650	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8Z75_09690	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H8Z75_09720	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8Z75_09720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8Z75_09740	COG2890	protein-(glutamine-N5) methyltransferase activity
H8Z75_09750	COG3634	alkyl hydroperoxide reductase activity
H8Z75_09755	COG0583	DNA-binding transcription factor activity
H8Z75_09760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8Z75_09765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8Z75_09775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8Z75_09790	COG0784	Response regulator, receiver
H8Z75_09790	COG2205	protein histidine kinase activity
H8Z75_09790	COG5002	protein histidine kinase activity
H8Z75_09810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z75_09815	COG0697	spore germination
H8Z75_09840	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H8Z75_09855	COG3386	PFAM SMP-30 Gluconolaconase
H8Z75_09875	COG1024	Enoyl-CoA hydratase
H8Z75_09890	COG0583	DNA-binding transcription factor activity
H8Z75_09895	COG3384	dioxygenase
H8Z75_09925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z75_09930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8Z75_09940	COG2096	Adenosyltransferase
H8Z75_09945	COG0123	including yeast histone deacetylase and acetoin utilization protein
H8Z75_09960	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H8Z75_09965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z75_09970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H8Z75_09975	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H8Z75_09980	COG2967	ApaG domain
H8Z75_09985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H8Z75_09995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H8Z75_10005	COG0747	negative chemotaxis
H8Z75_10030	COG0431	NADPH-dependent FMN reductase
H8Z75_10035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z75_10045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z75_10050	COG1116	anion transmembrane transporter activity
H8Z75_10075	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H8Z75_10080	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H8Z75_10100	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H8Z75_10110	COG0642	Histidine kinase
H8Z75_10125	COG4181	ATPase activity
H8Z75_10135	COG2175	clavaminate synthase activity
H8Z75_10145	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H8Z75_10150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z75_10170	COG4771	TonB-dependent receptor
H8Z75_10180	COG0667	Aldo Keto reductase
H8Z75_10185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8Z75_10190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z75_10200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8Z75_10215	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H8Z75_10255	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H8Z75_10265	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H8Z75_10270	COG2226	methyltransferase
H8Z75_10300	COG0366	Alpha amylase catalytic
H8Z75_10315	COG0604	alcohol dehydrogenase
H8Z75_10315	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z75_10315	COG3321	synthase
H8Z75_10325	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H8Z75_10340	COG0653	protein targeting
H8Z75_10345	COG0739	heme binding
H8Z75_10355	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H8Z75_10375	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8Z75_10380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8Z75_10400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H8Z75_10405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8Z75_10415	COG3116	cell division
H8Z75_10420	COG0275	rRNA processing
H8Z75_10455	COG0792	nuclease activity
H8Z75_10460	COG1988	membrane-bound metal-dependent
H8Z75_10465	COG0277	FAD linked oxidase domain protein
H8Z75_10480	COG0745	RESPONSE REGULATOR receiver
H8Z75_10490	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H8Z75_10500	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H8Z75_10520	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H8Z75_10525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8Z75_10530	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H8Z75_10545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8Z75_10545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8Z75_10555	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H8Z75_10560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H8Z75_10570	COG0488	(ABC) transporter
H8Z75_10580	COG0697	spore germination
H8Z75_10590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8Z75_10605	COG3791	Glutathione-dependent formaldehyde-activating
H8Z75_10630	COG2205	protein histidine kinase activity
H8Z75_10645	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H8Z75_10650	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H8Z75_10665	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8Z75_10690	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H8Z75_10695	COG0617	tRNA 3'-terminal CCA addition
H8Z75_10705	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H8Z75_10710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8Z75_10715	COG1609	Transcriptional regulator
H8Z75_10725	COG2188	Transcriptional regulator
H8Z75_10740	COG3250	beta-galactosidase activity
H8Z75_10790	COG1459	type II secretion system
H8Z75_10845	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H8Z75_10850	COG4191	Histidine kinase
H8Z75_10855	COG0784	Response regulator, receiver
H8Z75_10860	COG4251	negative regulation of phosphorylation
H8Z75_10865	COG2823	Periplasmic or secreted lipoprotein
H8Z75_10870	COG0673	inositol 2-dehydrogenase activity
H8Z75_10875	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H8Z75_10910	COG1056	cytidyltransferase-related domain
H8Z75_10910	COG1051	belongs to the nudix hydrolase family
H8Z75_10920	COG0583	DNA-binding transcription factor activity
H8Z75_10935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8Z75_10940	COG0321	lipoyl(octanoyl) transferase activity
H8Z75_10945	COG2921	Belongs to the UPF0250 family
H8Z75_10955	COG1686	Belongs to the peptidase S11 family
H8Z75_10960	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H8Z75_10965	COG2951	lytic endotransglycosylase activity
H8Z75_10975	COG0772	Belongs to the SEDS family
H8Z75_10990	COG1792	Involved in formation and maintenance of cell shape
H8Z75_10995	COG1077	Cell shape determining protein MreB Mrl
H8Z75_11000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8Z75_11005	COG3284	Transcriptional regulator
H8Z75_11055	COG5001	Diguanylate cyclase
H8Z75_11055	COG3300	MHYT domain
H8Z75_11060	COG2226	methyltransferase
H8Z75_11085	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H8Z75_11090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H8Z75_11095	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H8Z75_11105	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H8Z75_11115	COG2832	Protein of unknown function (DUF454)
H8Z75_11125	COG0436	Aminotransferase
H8Z75_11130	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8Z75_11160	COG0181	hydroxymethylbilane synthase activity
H8Z75_11200	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z75_11200	COG5297	Belongs to the glycosyl hydrolase family 6
H8Z75_11205	COG0840	transmembrane signaling receptor activity
H8Z75_11245	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H8Z75_11275	COG0697	spore germination
H8Z75_11315	COG1506	peptidase
H8Z75_11315	COG0823	Involved in the tonB-independent uptake of proteins
H8Z75_11345	COG0435	Glutathione S-transferase
H8Z75_11370	COG4221	oxidoreductase activity
H8Z75_11425	COG1802	Transcriptional regulator
H8Z75_11435	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8Z75_11460	COG3052	prosthetic group binding
H8Z75_11490	COG2353	YceI-like domain
H8Z75_11510	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8Z75_11525	COG3386	PFAM SMP-30 Gluconolaconase
H8Z75_11540	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H8Z75_11555	COG0459	protein refolding
H8Z75_11575	COG0300	oxidoreductase activity
H8Z75_11600	COG1324	tolerance protein
H8Z75_11610	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H8Z75_11615	COG0511	ligase activity, forming carbon-carbon bonds
H8Z75_11625	COG0439	Biotin carboxylase
H8Z75_11640	COG2264	protein methyltransferase activity
H8Z75_11660	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H8Z75_11665	COG4589	Belongs to the CDS family
H8Z75_11690	COG2453	phosphatase
H8Z75_11690	COG0671	phosphoesterase, PA-phosphatase related
H8Z75_11695	COG2267	carboxylic ester hydrolase activity
H8Z75_11700	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8Z75_11705	COG0138	bifunctional purine biosynthesis protein purh
H8Z75_11715	COG0151	Belongs to the GarS family
H8Z75_11730	COG2814	Major facilitator Superfamily
H8Z75_11735	COG0583	DNA-binding transcription factor activity
H8Z75_11740	COG2814	Major facilitator Superfamily
H8Z75_11755	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8Z75_11770	COG0316	Belongs to the HesB IscA family
H8Z75_11810	COG1051	belongs to the nudix hydrolase family
H8Z75_11825	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H8Z75_11835	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H8Z75_11845	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H8Z75_11850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z75_11860	COG0134	indole-3-glycerol-phosphate synthase activity
H8Z75_11865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8Z75_11890	COG1597	lipid kinase activity
H8Z75_11895	COG0456	acetyltransferase
H8Z75_11910	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H8Z75_11915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H8Z75_11935	COG3179	chitinase
H8Z75_11955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8Z75_11955	COG2111	Na H antiporter
H8Z75_11960	COG1006	Multisubunit Na H antiporter MnhC subunit
H8Z75_11975	COG2212	antiporter activity
H8Z75_11980	COG1320	monovalent cation:proton antiporter activity
H8Z75_11995	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H8Z75_12020	COG3104	oligopeptide transport
H8Z75_12025	COG3483	tryptophan 2,3-dioxygenase activity
H8Z75_12035	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H8Z75_12060	COG0513	Belongs to the DEAD box helicase family
H8Z75_12070	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z75_12075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z75_12105	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z75_12110	COG0702	epimerase
H8Z75_12145	COG0297	glycogen (starch) synthase activity
H8Z75_12155	COG2354	Protein conserved in bacteria
H8Z75_12170	COG3264	Mechanosensitive ion channel
H8Z75_12170	COG1511	domain protein
H8Z75_12240	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8Z75_12320	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8Z75_12325	COG1040	competence protein
H8Z75_12330	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H8Z75_12335	COG0156	8-amino-7-oxononanoate synthase activity
H8Z75_12345	COG2267	carboxylic ester hydrolase activity
H8Z75_12375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H8Z75_12385	COG0445	tRNA wobble uridine modification
H8Z75_12395	COG0657	acetylesterase activity
H8Z75_12405	COG1414	Transcriptional regulator
H8Z75_12415	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H8Z75_12420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z75_12430	COG3485	protocatechuate 3,4-dioxygenase
H8Z75_12435	COG3485	protocatechuate 3,4-dioxygenase
H8Z75_12450	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H8Z75_12475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H8Z75_12480	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H8Z75_12540	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H8Z75_12585	COG1733	regulation of RNA biosynthetic process
H8Z75_12590	COG0702	epimerase
H8Z75_12620	COG0583	DNA-binding transcription factor activity
H8Z75_12625	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8Z75_12630	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H8Z75_12650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z75_12660	COG0745	RESPONSE REGULATOR receiver
H8Z75_12680	COG1902	pentaerythritol trinitrate reductase activity
H8Z75_12685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H8Z75_12700	COG2814	Major facilitator Superfamily
H8Z75_12720	COG0084	hydrolase, TatD family'
H8Z75_12750	COG1957	nucleoside hydrolase
H8Z75_12780	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H8Z75_12800	COG2072	flavoprotein involved in K transport
H8Z75_12805	COG2351	hydroxyisourate hydrolase activity
H8Z75_12810	COG4807	Protein conserved in bacteria
H8Z75_12830	COG1187	pseudouridine synthase activity
H8Z75_12845	COG2130	NADP-dependent
H8Z75_12870	COG1764	response to oxidative stress
H8Z75_12875	COG1846	Transcriptional regulator
H8Z75_12880	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H8Z75_12890	COG0697	spore germination
H8Z75_12900	COG0523	cobalamin synthesis protein
H8Z75_12965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H8Z75_12970	COG4770	biotin carboxylase activity
H8Z75_13000	COG2224	Isocitrate lyase
H8Z75_13005	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H8Z75_13010	COG0583	DNA-binding transcription factor activity
H8Z75_13015	COG0475	glutathione-regulated potassium exporter activity
H8Z75_13045	COG0339	signal peptide processing
H8Z75_13080	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8Z75_13090	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8Z75_13100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z75_13105	COG0318	PFAM AMP-dependent synthetase and ligase
H8Z75_13110	COG0727	PFAM Uncharacterised protein family (UPF0153)
H8Z75_13115	COG0596	Alpha beta hydrolase
H8Z75_13125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8Z75_13165	COG2205	protein histidine kinase activity
H8Z75_13170	COG0028	Belongs to the TPP enzyme family
H8Z75_13185	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H8Z75_13190	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H8Z75_13195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8Z75_13230	COG0183	Belongs to the thiolase family
H8Z75_13240	COG0346	lactoylglutathione lyase activity
H8Z75_13255	COG2032	superoxide dismutase activity
H8Z75_13260	COG2204	response regulator
H8Z75_13265	COG3852	Histidine kinase
H8Z75_13270	COG0004	ammonium transporteR
H8Z75_13275	COG0347	Belongs to the P(II) protein family
H8Z75_13280	COG0174	glutamine synthetase
H8Z75_13285	COG1968	undecaprenyl-diphosphatase activity
H8Z75_13330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z75_13340	COG2062	phosphohistidine phosphatase, SixA
H8Z75_13345	COG0489	protein tyrosine kinase activity
H8Z75_13385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8Z75_13425	COG1119	ATPase activity
H8Z75_13435	COG1752	Esterase of the alpha-beta hydrolase superfamily
H8Z75_13445	COG1522	sequence-specific DNA binding
H8Z75_13450	COG3186	Phenylalanine-4-hydroxylase
H8Z75_13465	COG2755	lipolytic protein G-D-S-L family
H8Z75_13475	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z75_13480	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H8Z75_13485	COG1609	Transcriptional regulator
H8Z75_13490	COG3507	Belongs to the glycosyl hydrolase 43 family
H8Z75_13505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H8Z75_13515	COG0657	acetylesterase activity
H8Z75_13515	COG2755	lipolytic protein G-D-S-L family
H8Z75_13535	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8Z75_13540	COG0366	Alpha amylase catalytic
H8Z75_13645	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H8Z75_13670	COG2197	response regulator
H8Z75_13675	COG4585	Histidine kinase
H8Z75_13685	COG1304	FMN binding
H8Z75_13710	COG1012	belongs to the aldehyde dehydrogenase family
H8Z75_13720	COG0662	Cupin 2, conserved barrel domain protein
H8Z75_13730	COG4772	TonB-dependent receptor
H8Z75_13770	COG0714	Associated with various cellular activities
H8Z75_13815	COG0477	Major facilitator Superfamily
H8Z75_13820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8Z75_13865	COG3237	CsbD-like
H8Z75_13930	COG2249	NAD(P)H dehydrogenase (quinone) activity
H8Z75_13950	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z75_13955	COG0300	oxidoreductase activity
H8Z75_13975	COG1272	protein, Hemolysin III
H8Z75_13980	COG1111	helicase
H8Z75_13980	COG1205	dead DEAH box helicase
H8Z75_14095	COG1132	(ABC) transporter
H8Z75_14145	COG0297	glycogen (starch) synthase activity
H8Z75_14145	COG0438	transferase activity, transferring glycosyl groups
H8Z75_14150	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H8Z75_14215	COG0067	glutamate synthase
H8Z75_14215	COG0069	glutamate synthase activity
H8Z75_14215	COG0070	glutamate synthase
H8Z75_14220	COG0493	'glutamate synthase
H8Z75_14230	COG1064	alcohol dehydrogenase
H8Z75_14235	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z75_14245	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z75_14255	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8Z75_14275	COG4942	peptidase
H8Z75_14280	COG0793	Belongs to the peptidase S41A family
H8Z75_14325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z75_14335	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H8Z75_14365	COG0501	Belongs to the peptidase M48B family
H8Z75_14380	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8Z75_14390	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H8Z75_14400	COG0594	ribonuclease P activity
H8Z75_14410	COG0726	polysaccharide deacetylase
H8Z75_14415	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H8Z75_14430	COG0584	glycerophosphoryl diester phosphodiesterase
H8Z75_14440	COG0861	Integral membrane protein TerC family
H8Z75_14445	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H8Z75_14465	COG1929	Belongs to the glycerate kinase type-1 family
H8Z75_14470	COG3835	regulator
H8Z75_14475	COG3706	GGDEF domain
H8Z75_14490	COG0531	amino acid
H8Z75_14500	COG0625	glutathione transferase activity
H8Z75_14515	COG0604	alcohol dehydrogenase
H8Z75_14520	COG1322	Protein conserved in bacteria
H8Z75_14530	COG0386	Belongs to the glutathione peroxidase family
H8Z75_14540	COG2853	Lipoprotein
H8Z75_14555	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8Z75_14560	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8Z75_14565	COG1127	ABC transporter
H8Z75_14585	COG1074	ATP-dependent DNA helicase activity
H8Z75_14640	COG0564	pseudouridine synthase activity
H8Z75_14675	COG1487	ribonuclease activity
H8Z75_14680	COG4691	Plasmid stability protein
H8Z75_14700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z75_14710	COG0477	Major facilitator Superfamily
H8Z75_14725	COG1566	PFAM secretion protein HlyD family protein
H8Z75_14740	COG0302	gtp cyclohydrolase
H8Z75_14765	COG0730	response to heat
H8Z75_14770	COG3012	SEC-C Motif Domain Protein
H8Z75_14800	COG3135	benzoate transporter
H8Z75_14830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H8Z75_14840	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H8Z75_14850	COG1435	thymidine kinase activity
H8Z75_14855	COG0210	DNA helicase
H8Z75_14870	COG3132	Protein of unknown function, DUF480
H8Z75_14875	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H8Z75_14880	COG0284	orotidine-5'-phosphate decarboxylase activity
H8Z75_14910	COG2937	Belongs to the GPAT DAPAT family
H8Z75_14990	COG2211	Major facilitator Superfamily
H8Z75_15005	COG3693	PFAM glycoside hydrolase, family 10
H8Z75_15015	COG3693	PFAM glycoside hydrolase, family 10
H8Z75_15020	COG1904	glucuronate isomerase
H8Z75_15035	COG3386	PFAM SMP-30 Gluconolaconase
H8Z75_15065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8Z75_15115	COG0246	Mannitol dehydrogenase
H8Z75_15120	COG1472	Belongs to the glycosyl hydrolase 3 family
H8Z75_15130	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z75_15140	COG3661	Belongs to the glycosyl hydrolase 67 family
H8Z75_15150	COG2115	Belongs to the xylose isomerase family
H8Z75_15160	COG2974	May be involved in recombination
H8Z75_15180	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8Z75_15190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8Z75_15195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8Z75_15200	COG0805	protein transport
H8Z75_15210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8Z75_15210	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z75_15220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z75_15225	COG0752	glycyl-tRNA synthetase alpha subunit
H8Z75_15260	COG0729	surface antigen
H8Z75_15265	COG2911	Protein conserved in bacteria
H8Z75_15295	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z75_15300	COG3265	gluconokinase activity
H8Z75_15305	COG2211	Major facilitator Superfamily
H8Z75_15320	COG2205	protein histidine kinase activity
H8Z75_15325	COG1971	Probably functions as a manganese efflux pump
H8Z75_15330	COG1414	Transcriptional regulator
H8Z75_15335	COG0738	Major facilitator superfamily
H8Z75_15340	COG3254	rhamnose metabolic process
H8Z75_15345	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z75_15350	COG0179	Fumarylacetoacetate (FAA) hydrolase
H8Z75_15355	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z75_15375	COG3507	Belongs to the glycosyl hydrolase 43 family
H8Z75_15400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8Z75_15410	COG3162	membrane
H8Z75_15415	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8Z75_15425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8Z75_15440	COG0708	Exodeoxyribonuclease III
H8Z75_15455	COG2091	lysine biosynthetic process via aminoadipic acid
H8Z75_15465	COG3540	Alkaline phosphatase
H8Z75_15470	COG0357	Ribosomal RNA small subunit methyltransferase G
H8Z75_15490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z75_15520	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H8Z75_15530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z75_15540	COG0210	DNA helicase
H8Z75_15715	COG0631	protein serine/threonine phosphatase activity
H8Z75_15720	COG0515	serine threonine protein kinase
H8Z75_15720	COG2815	serine threonine protein kinase
H8Z75_15765	COG0408	coproporphyrinogen oxidase activity
H8Z75_15780	COG0823	Involved in the tonB-independent uptake of proteins
H8Z75_15780	COG1506	peptidase
H8Z75_15780	COG4946	Tricorn protease homolog
H8Z75_15805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8Z75_15820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z75_15855	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z75_15875	COG0463	Glycosyl transferase, family 2
H8Z75_15885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8Z75_15890	COG3100	YcgL domain-containing protein
H8Z75_15905	COG3387	PFAM Glycoside hydrolase 15-related
H8Z75_15910	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8Z75_15925	COG2239	Acts as a magnesium transporter
H8Z75_15940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8Z75_15945	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8Z75_15980	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H8Z75_15990	COG0842	Transport permease protein
H8Z75_15995	COG1131	(ABC) transporter
H8Z75_16000	COG0543	2 iron, 2 sulfur cluster binding
H8Z75_16000	COG0633	Ferredoxin
H8Z75_16090	COG0625	glutathione transferase activity
H8Z75_16155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8Z75_16160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8Z75_16175	COG1199	ATP-dependent helicase activity
H8Z75_16200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8Z75_16245	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H8Z75_16300	COG3237	CsbD-like
H8Z75_16305	COG0180	Tryptophanyl-tRNA synthetase
H8Z75_16310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z75_16350	COG1136	(ABC) transporter
H8Z75_16355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z75_16360	COG4585	Histidine kinase
H8Z75_16365	COG2197	response regulator
H8Z75_16380	COG0753	catalase activity
H8Z75_16395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8Z75_16400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8Z75_16425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8Z75_16450	COG0642	Histidine kinase
H8Z75_16460	COG1090	epimerase
H8Z75_16495	COG1690	Belongs to the RtcB family
H8Z75_16520	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H8Z75_16535	COG0606	chelatase, subunit chli
H8Z75_16570	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H8Z75_16575	COG1166	arginine decarboxylase activity
H8Z75_16590	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H8Z75_16590	COG2755	lipolytic protein G-D-S-L family
H8Z75_16595	COG4221	oxidoreductase activity
H8Z75_16615	COG2003	Belongs to the UPF0758 family
H8Z75_16620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H8Z75_16625	COG0756	dUTP diphosphatase activity
H8Z75_16645	COG0463	Glycosyl transferase, family 2
H8Z75_16665	COG1192	Involved in chromosome partitioning
H8Z75_16675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8Z75_16680	COG0708	Exodeoxyribonuclease III
H8Z75_16685	COG2223	nitrite transmembrane transporter activity
H8Z75_16700	COG0739	heme binding
H8Z75_16745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H8Z75_16755	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H8Z75_16785	COG0109	protoheme IX farnesyltransferase activity
H8Z75_16800	COG0358	DNA primase activity
H8Z75_16805	COG1295	ribonuclease BN
H8Z75_16810	COG1610	YqeY-like protein
H8Z75_16820	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H8Z75_16825	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H8Z75_16835	COG2133	pyrroloquinoline quinone binding
H8Z75_16855	COG0531	amino acid
H8Z75_16865	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z75_16875	COG3023	N-Acetylmuramoyl-L-alanine amidase
H8Z75_16880	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H8Z75_16920	COG5383	Protein conserved in bacteria
H8Z75_16930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8Z75_16940	COG1473	amidohydrolase
H8Z75_16945	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8Z75_16945	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8Z75_16950	COG1652	LysM domain
H8Z75_16965	COG1518	maintenance of DNA repeat elements
H8Z75_17010	COG0583	DNA-binding transcription factor activity
H8Z75_17015	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H8Z75_17025	COG3118	belongs to the thioredoxin family
H8Z75_17030	COG0513	Belongs to the DEAD box helicase family
H8Z75_17035	COG2884	Cell division ATP-binding protein ftsE
H8Z75_17040	COG2177	Part of the ABC transporter FtsEX involved in
H8Z75_17045	COG2201	protein-glutamate methylesterase activity
H8Z75_17050	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H8Z75_17055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8Z75_17060	COG2860	membrane
H8Z75_17065	COG1252	NADH dehydrogenase
H8Z75_17080	COG0625	glutathione transferase activity
H8Z75_17105	COG0534	Mate efflux family protein
H8Z75_17110	COG0616	signal peptide processing
H8Z75_17120	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z75_17135	COG0009	L-threonylcarbamoyladenylate synthase
H8Z75_17140	COG1754	DNA topoisomerase type I activity
H8Z75_17140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z75_17160	COG0758	DNA mediated transformation
H8Z75_17165	COG1652	LysM domain
H8Z75_17170	COG0242	peptide deformylase activity
H8Z75_17175	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H8Z75_17180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H8Z75_17180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8Z75_17230	COG1560	Kdo2-lipid A biosynthetic process
H8Z75_17235	COG1490	D-aminoacyl-tRNA deacylase activity
H8Z75_17240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8Z75_17425	COG3179	chitinase
H8Z75_17470	COG4695	Portal protein
H8Z75_17500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8Z75_17515	COG0431	NADPH-dependent FMN reductase
H8Z75_17545	COG0024	Methionine aminopeptidase
H8Z75_17590	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8Z75_17595	COG0583	DNA-binding transcription factor activity
H8Z75_17610	COG0840	transmembrane signaling receptor activity
H8Z75_17625	COG0251	oxidation-reduction process
H8Z75_17700	COG1063	alcohol dehydrogenase
H8Z75_17725	COG1132	(ABC) transporter
H8Z75_17745	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8Z75_17750	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z75_17765	COG1294	oxidase, subunit
H8Z75_17770	COG1271	oxidase subunit
H8Z75_17820	COG3685	Protein conserved in bacteria
H8Z75_17835	COG2972	Histidine kinase
H8Z75_17850	COG0531	amino acid
H8Z75_17870	COG3590	peptidase
H8Z75_17880	COG0667	Aldo Keto reductase
H8Z75_17890	COG0583	DNA-binding transcription factor activity
H8Z75_17900	COG3384	dioxygenase
H8Z75_17910	COG1573	uracil-dna glycosylase
H8Z75_17915	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H8Z75_17925	COG1131	(ABC) transporter
H8Z75_17930	COG0842	Transport permease protein
H8Z75_17995	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8Z75_18015	COG2202	Pas domain
H8Z75_18015	COG2205	protein histidine kinase activity
H8Z75_18035	COG2813	Specifically methylates the guanine in position
H8Z75_18040	COG1187	pseudouridine synthase activity
H8Z75_18045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8Z75_18065	COG0784	Response regulator, receiver
H8Z75_18065	COG2198	Histidine kinase
H8Z75_18065	COG5002	protein histidine kinase activity
H8Z75_18075	COG1666	GTP binding
H8Z75_18085	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H8Z75_18090	COG2011	ABC-type metal ion transport system permease component
H8Z75_18130	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8Z75_18140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8Z75_18155	COG0356	it plays a direct role in the translocation of protons across the membrane
H8Z75_18165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8Z75_18170	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H8Z75_18175	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H8Z75_18180	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H8Z75_18190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H8Z75_18205	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8Z75_18230	COG0577	efflux transmembrane transporter activity
H8Z75_18235	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8Z75_18235	COG1136	(ABC) transporter
H8Z75_18240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8Z75_18315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8Z75_18320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8Z75_18335	COG2819	hydrolase of the alpha beta superfamily
H8Z75_18340	COG1956	GAF domain-containing protein
H8Z75_18345	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H8Z75_18370	COG0513	Belongs to the DEAD box helicase family
H8Z75_18380	COG0625	glutathione transferase activity
H8Z75_18410	COG0626	cystathionine gamma-synthase activity
H8Z75_18430	COG0438	transferase activity, transferring glycosyl groups
H8Z75_18430	COG1216	Glycosyl transferase, family 2
H8Z75_18435	COG3754	Rhamnan synthesis protein F
H8Z75_18445	COG2226	methyltransferase
H8Z75_18465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8Z75_18475	COG0300	oxidoreductase activity
H8Z75_18485	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H8Z75_18485	COG0546	phosphoglycolate phosphatase activity
H8Z75_18500	COG2086	electron transfer activity
H8Z75_18530	COG0662	Cupin 2, conserved barrel domain protein
H8Z75_18530	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H8Z75_18535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8Z75_18570	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8Z75_18570	COG3218	ABC-type transport auxiliary lipoprotein component
H8Z75_18575	COG1127	ABC transporter
H8Z75_18595	COG0442	prolyl-tRNA aminoacylation
H8Z75_18605	COG1183	phosphatidylcholine synthase activity
H8Z75_18655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8Z75_18665	COG0795	lipopolysaccharide-transporting ATPase activity
H8Z75_18680	COG4974	Belongs to the 'phage' integrase family
H8Z75_18685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8Z75_18700	COG1404	Belongs to the peptidase S8 family
H8Z75_18710	COG1404	Belongs to the peptidase S8 family
H8Z75_18715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z75_18720	COG1459	type II secretion system
H8Z75_18725	COG2165	general secretion pathway protein
H8Z75_18730	COG4970	Tfp pilus assembly protein FimT
H8Z75_18735	COG2165	general secretion pathway protein
H8Z75_18740	COG4795	General secretion pathway protein
H8Z75_18745	COG3156	type II secretion system protein K
H8Z75_18750	COG3166	PFAM Fimbrial assembly family protein
H8Z75_18785	COG2188	Transcriptional regulator
H8Z75_18830	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H8Z75_18845	COG1215	transferase activity, transferring glycosyl groups
H8Z75_18855	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H8Z75_18860	COG0457	Tetratricopeptide repeat
H8Z75_18880	COG0242	peptide deformylase activity
H8Z75_18885	COG1307	EDD domain protein, DegV family
H8Z75_18915	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8Z75_18920	COG0726	polysaccharide deacetylase
H8Z75_18925	COG4773	Receptor
H8Z75_18945	COG1162	GTPase activity
H8Z75_18970	COG2211	Major facilitator Superfamily
H8Z75_18975	COG1609	Transcriptional regulator
H8Z75_18980	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z75_18985	COG2851	Citrate transporter
H8Z75_19000	COG0642	Histidine kinase
H8Z75_19025	COG0667	Aldo Keto reductase
H8Z75_19030	COG0583	DNA-binding transcription factor activity
H8Z75_19055	COG1301	dicarboxylic acid transport
H8Z75_19085	COG1560	Kdo2-lipid A biosynthetic process
H8Z75_19095	COG1538	Outer membrane efflux protein
H8Z75_19100	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H8Z75_19120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H8Z75_19125	COG0066	3-isopropylmalate dehydratase activity
H8Z75_19130	COG0473	3-isopropylmalate dehydrogenase activity
H8Z75_19135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H8Z75_19155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H8Z75_19160	COG0405	Gamma-glutamyltransferase
H8Z75_19165	COG0840	transmembrane signaling receptor activity
H8Z75_19175	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H8Z75_19180	COG3710	Transcriptional regulator
H8Z75_19200	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H8Z75_19225	COG0563	adenylate kinase activity
H8Z75_19230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8Z75_19240	COG3781	membrane
H8Z75_19255	COG1028	Short-chain dehydrogenase reductase Sdr
H8Z75_19265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8Z75_19270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8Z75_19315	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8Z75_19330	COG0352	thiamine-phosphate diphosphorylase activity
H8Z75_19335	COG1773	rubredoxin
H8Z75_19340	COG2912	Transglutaminase-like superfamily
H8Z75_19350	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H8Z75_19360	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H8Z75_19380	COG3079	Belongs to the UPF0149 family
H8Z75_19385	COG0006	proline dipeptidase activity
H8Z75_19395	COG0006	proline dipeptidase activity
H8Z75_19410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8Z75_19415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8Z75_19425	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H8Z75_19430	COG1561	YicC-like family, N-terminal region
H8Z75_19445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8Z75_19455	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8Z75_19480	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H8Z75_19510	COG0714	Associated with various cellular activities
H8Z75_19530	COG2304	oxidoreductase activity
H8Z75_19550	COG0596	Alpha beta hydrolase
H8Z75_19555	COG4773	Receptor
H8Z75_19565	COG0739	heme binding
H8Z75_19570	COG1376	ErfK ybiS ycfS ynhG family protein
H8Z75_19605	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H8Z75_19615	COG0725	ABC transporter, periplasmic molybdate-binding protein
H8Z75_19620	COG3453	Protein conserved in bacteria
H8Z75_19620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8Z75_19630	COG3047	cAMP biosynthetic process
H8Z75_19635	COG3047	cAMP biosynthetic process
H8Z75_19645	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8Z75_19665	COG0126	phosphoglycerate kinase activity
H8Z75_19675	COG0469	pyruvate kinase activity
H8Z75_19680	COG3588	fructose-bisphosphate aldolase
H8Z75_19685	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H8Z75_19700	COG1648	precorrin-2 dehydrogenase activity
H8Z75_19700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8Z75_19740	COG0175	sulfate reduction
H8Z75_19745	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8Z75_19750	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8Z75_19760	COG0529	Catalyzes the synthesis of activated sulfate
H8Z75_19760	COG2895	sulfate adenylyltransferase (ATP) activity
H8Z75_19810	COG0308	aminopeptidase N
H8Z75_19820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8Z75_19835	COG4948	Mandelate Racemase Muconate Lactonizing
H8Z75_19840	COG3250	beta-galactosidase activity
H8Z75_19860	COG1970	mechanosensitive ion channel activity
H8Z75_19880	COG0471	metal ion transport
H8Z75_19880	COG3273	potassium ion transport
H8Z75_19885	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H8Z75_19890	COG2022	thiamine diphosphate biosynthetic process
H8Z75_19985	COG0745	RESPONSE REGULATOR receiver
H8Z75_19990	COG5002	protein histidine kinase activity
H8Z75_20000	COG2801	Transposase and inactivated derivatives
H8Z75_20015	COG0237	dephospho-CoA kinase activity
H8Z75_20020	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H8Z75_20050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8Z75_20065	COG0045	succinate-CoA ligase (ADP-forming) activity
H8Z75_20070	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H8Z75_20140	COG2951	lytic endotransglycosylase activity
H8Z75_20150	COG2801	Transposase and inactivated derivatives
H8Z75_20160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H8Z75_20160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8Z75_20170	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8Z75_20175	COG0564	pseudouridine synthase activity
H8Z75_20190	COG3011	Protein conserved in bacteria
H8Z75_20195	COG0840	transmembrane signaling receptor activity
H8Z75_20210	COG3387	PFAM Glycoside hydrolase 15-related
H8Z75_20215	COG1877	trehalose-phosphatase activity
H8Z75_20255	COG2827	Endonuclease containing a URI domain
H8Z75_20260	COG4771	TonB-dependent receptor
H8Z75_20265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8Z75_20270	COG0667	Aldo Keto reductase
H8Z75_20275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H8Z75_20280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8Z75_20285	COG1116	anion transmembrane transporter activity
H8Z75_20290	COG0542	response to heat
H8Z75_20295	COG4206	TonB-dependent receptor
H8Z75_20315	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H8Z75_20325	COG1492	cobalamin metabolic process
H8Z75_20335	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H8Z75_20365	COG0019	diaminopimelate decarboxylase activity
H8Z75_20380	COG4264	IucA IucC family
H8Z75_20390	COG4772	TonB-dependent receptor
H8Z75_20415	COG4651	solute:proton antiporter activity
H8Z75_20415	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8Z75_20485	COG0477	Major facilitator Superfamily
H8Z75_20500	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H8Z75_20515	COG0217	transcriptional regulatory protein
H8Z75_20520	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H8Z75_20525	COG0632	four-way junction helicase activity
H8Z75_20530	COG3158	transport of potassium into the cell
H8Z75_20540	COG2255	four-way junction helicase activity
H8Z75_20545	COG0824	Thioesterase
H8Z75_20555	COG0848	biopolymer transport protein
H8Z75_20565	COG0823	Involved in the tonB-independent uptake of proteins
H8Z75_20570	COG2885	chlorophyll binding
H8Z75_20615	COG0840	transmembrane signaling receptor activity
H8Z75_20650	COG0514	ATP-dependent DNA helicase (RecQ)
H8Z75_20655	COG0783	Belongs to the Dps family
H8Z75_20675	COG0837	glucose binding
H8Z75_20690	COG0535	radical SAM domain protein
H8Z75_20700	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
H8Z75_20705	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H8Z75_20715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8Z75_20730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8Z75_20740	COG1199	ATP-dependent helicase activity
H8Z75_20750	COG1397	ADP-ribosylglycohydrolase
H8Z75_20760	COG0189	ligase activity
H8Z75_20775	COG0835	chemotaxis
H8Z75_20780	COG0840	transmembrane signaling receptor activity
H8Z75_20785	COG0643	Histidine kinase
H8Z75_20785	COG0784	Response regulator, receiver
H8Z75_20785	COG2198	Histidine kinase
H8Z75_20805	COG1446	asparaginase
H8Z75_20810	COG3142	Participates in the control of copper homeostasis
H8Z75_20845	COG3537	Alpha-1,2-mannosidase
H8Z75_20865	COG0531	amino acid
H8Z75_20890	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H8Z75_20910	COG0837	glucose binding
H8Z75_20915	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H8Z75_20925	COG0494	nUDIX hydrolase
H8Z75_20935	COG3956	TIGRFAM MazG family protein
H8Z75_20940	COG1742	UPF0060 membrane protein
H8Z75_20945	COG0330	HflC and HflK could
H8Z75_20960	COG0509	glycine decarboxylation via glycine cleavage system
H8Z75_20990	COG1960	acyl-CoA dehydrogenase activity
H8Z75_21000	COG1309	transcriptional regulator
H8Z75_21020	COG4771	TonB-dependent receptor
H8Z75_21030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H8Z75_21035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8Z75_21040	COG0463	Glycosyl transferase, family 2
H8Z75_21045	COG0516	GMP reductase activity
H8Z75_21045	COG0517	IMP dehydrogenase activity
H8Z75_21050	COG2982	Protein involved in outer membrane biogenesis
H8Z75_21055	COG1272	protein, Hemolysin III
H8Z75_21060	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H8Z75_21065	COG0739	heme binding
H8Z75_21070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8Z75_21075	COG0626	cystathionine gamma-synthase activity
H8Z75_21080	COG0460	homoserine dehydrogenase
H8Z75_21080	COG0527	aspartate kinase activity
H8Z75_21090	COG1760	l-serine dehydratase
H8Z75_21110	COG2353	YceI-like domain
H8Z75_21115	COG2198	Histidine kinase
H8Z75_21115	COG0784	Response regulator, receiver
H8Z75_21115	COG2205	protein histidine kinase activity
H8Z75_21135	COG0477	Major facilitator Superfamily
H8Z75_21220	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H8Z75_21240	COG1842	Phage shock protein A
H8Z75_21265	COG0754	glutathionylspermidine amidase activity
H8Z75_21275	COG2814	Major facilitator Superfamily
H8Z75_21310	COG1234	tRNA 3'-trailer cleavage
H8Z75_21330	COG0531	amino acid
H8Z75_21340	COG2197	response regulator
H8Z75_21360	COG1113	amino acid transport
H8Z75_21375	COG1294	oxidase, subunit
H8Z75_21390	COG2239	Acts as a magnesium transporter
H8Z75_21395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8Z75_21400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z75_21410	COG1660	Displays ATPase and GTPase activities
H8Z75_21415	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H8Z75_21420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8Z75_21435	COG1137	ATPase activity
H8Z75_21440	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H8Z75_21450	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H8Z75_21460	COG0271	Belongs to the BolA IbaG family
H8Z75_21465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H8Z75_21495	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H8Z75_21505	COG0628	permease
H8Z75_21520	COG3178	'Phosphotransferase
H8Z75_21530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8Z75_21535	COG1555	photosystem II stabilization
H8Z75_21550	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8Z75_21555	COG1477	protein flavinylation
H8Z75_21580	COG3128	pkhd-type hydroxylase
H8Z75_21585	COG4774	siderophore transport
H8Z75_21590	COG2146	nitrite reductase [NAD(P)H] activity
H8Z75_21600	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H8Z75_21605	COG0719	Fe-S assembly protein
H8Z75_21610	COG0396	ATPase activity
H8Z75_21615	COG0719	Fe-S assembly protein
H8Z75_21620	COG1959	2 iron, 2 sulfur cluster binding
H8Z75_21630	COG0693	protein deglycase activity
H8Z75_21650	COG0739	heme binding
H8Z75_21665	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H8Z75_21680	COG5297	Belongs to the glycosyl hydrolase family 6
H8Z75_21695	COG0519	Catalyzes the synthesis of GMP from XMP
H8Z75_21700	COG1678	Uncharacterized ACR, COG1678
H8Z75_21705	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H8Z75_21710	COG0540	Belongs to the ATCase OTCase family
H8Z75_21715	COG1764	response to oxidative stress
H8Z75_21725	COG0384	phenazine biosynthesis protein PhzF
H8Z75_21730	COG0384	phenazine biosynthesis protein PhzF
H8Z75_21735	COG0527	aspartate kinase activity
H8Z75_21760	COG0142	geranyltranstransferase activity
H8Z75_21765	COG0629	single-stranded DNA binding
H8Z75_21790	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8Z75_21800	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H8Z75_21835	COG2879	small protein
H8Z75_21840	COG1966	Carbon starvation protein
H8Z75_21845	COG1741	Belongs to the pirin family
H8Z75_21860	COG1741	Belongs to the pirin family
H8Z75_21870	COG1515	deoxyribonuclease V activity
H8Z75_21875	COG0588	phosphoglycerate mutase activity
H8Z75_21885	COG3590	peptidase
H8Z75_21890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8Z75_21895	COG2201	protein-glutamate methylesterase activity
H8Z75_21900	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8Z75_21905	COG2202	Pas domain
H8Z75_21905	COG2199	diguanylate cyclase activity
H8Z75_21905	COG2200	EAL domain
H8Z75_21910	COG0835	chemotaxis
H8Z75_21915	COG0840	transmembrane signaling receptor activity
H8Z75_21920	COG0643	Histidine kinase
H8Z75_21920	COG2198	Histidine kinase
H8Z75_21960	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H8Z75_21965	COG0745	RESPONSE REGULATOR receiver
H8Z75_21970	COG2205	protein histidine kinase activity
H8Z75_21985	COG4452	Inner membrane protein CreD
H8Z75_22010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8Z75_22015	COG0735	belongs to the Fur family
H8Z75_22040	COG1309	transcriptional regulator
H8Z75_22050	COG2207	Transcriptional regulator
H8Z75_22060	COG0583	DNA-binding transcription factor activity
H8Z75_22070	COG0667	Aldo Keto reductase
H8Z75_22190	COG5002	protein histidine kinase activity
H8Z75_22190	COG5001	Diguanylate cyclase
H8Z75_22195	COG1187	pseudouridine synthase activity
H8Z75_22215	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H8Z75_22225	COG0475	glutathione-regulated potassium exporter activity
H8Z75_22230	COG5000	phosphorelay sensor kinase activity
H8Z75_22230	COG5002	protein histidine kinase activity
H8Z75_22270	COG1132	(ABC) transporter
H8Z75_22315	COG2155	Conserved Protein
H8Z75_22340	COG3118	belongs to the thioredoxin family
H8Z75_22365	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H8Z75_22380	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H8Z75_22395	COG2968	Membrane
H8Z75_22420	COG0312	modulator of DNA gyrase
H8Z75_22425	COG3028	Belongs to the UPF0307 family
H8Z75_22430	COG0312	modulator of DNA gyrase
H8Z75_22440	COG4104	PAAR repeat-containing protein
H8Z75_22450	COG1722	exodeoxyribonuclease VII activity
H8Z75_22455	COG0037	tRNA processing
H8Z75_22470	COG4106	trans-aconitate 2-methyltransferase activity
H8Z75_22480	COG0791	NLP P60 protein
H8Z75_22485	COG0791	NLP P60 protein
H8Z75_22490	COG1047	Peptidyl-prolyl cis-trans
H8Z75_22495	COG2311	Membrane
H8Z75_22500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8Z75_22505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8Z75_22525	COG3590	peptidase
H8Z75_22555	COG0717	Belongs to the dCTP deaminase family
H8Z75_22580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8Z75_22600	COG0494	nUDIX hydrolase
H8Z75_22605	COG0433	COG0433 Predicted ATPase
H8Z75_22615	COG0688	phosphatidylethanolamine metabolic process
H8Z75_22625	COG2890	protein-(glutamine-N5) methyltransferase activity
H8Z75_22630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H8Z75_22635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8Z75_22640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H8Z75_22665	COG0135	phosphoribosylanthranilate isomerase activity
H8Z75_22675	COG0133	tryptophan synthase activity
H8Z75_22685	COG0159	tryptophan synthase activity
H8Z75_22690	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H8Z75_22695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8Z75_22725	COG0300	oxidoreductase activity
H8Z75_22730	COG0149	triose-phosphate isomerase activity
H8Z75_22745	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z75_22750	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z75_22755	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z75_22765	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H8Z75_22770	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H8Z75_22780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H8Z75_22785	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8Z75_22810	COG1007	ATP synthesis coupled electron transport
H8Z75_22820	COG0779	Required for maturation of 30S ribosomal subunits
H8Z75_22825	COG0195	Participates in both transcription termination and antitermination
H8Z75_22830	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H8Z75_22835	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H8Z75_22840	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H8Z75_22845	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H8Z75_22850	COG1185	polyribonucleotide nucleotidyltransferase activity
H8Z75_22885	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8Z75_22895	COG2095	MarC family integral membrane protein
H8Z75_22905	COG1611	Belongs to the LOG family
H8Z75_22910	COG3275	phosphorelay sensor kinase activity
H8Z75_23070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8Z75_23095	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H8Z75_23650	COG1674	ftsk spoiiie
H8Z75_23710	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z75_23730	COG3012	SEC-C Motif Domain Protein
H8Z75_23730	COG3318	Belongs to the UPF0149 family
H8Z75_23765	COG1192	Involved in chromosome partitioning
H8Z75_23970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8Z75_23995	COG3012	SEC-C Motif Domain Protein
H8Z75_23995	COG3318	Belongs to the UPF0149 family
H8Z75_24010	COG1192	Involved in chromosome partitioning