locus-tag	class	description
J171_00032	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J171_00041	COG2951	lytic endotransglycosylase activity
J171_00042	COG4644	lycopene metabolic process
J171_00072	COG2948	multi-organism process
J171_00073	COG3504	Conjugal transfer protein
J171_00094	COG4456	Virulence-associated protein
J171_00095	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J171_00103	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J171_00104	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J171_00106	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J171_00108	COG0187	DNA topoisomerase II activity
J171_00110	COG0501	Belongs to the peptidase M48B family
J171_00116	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
J171_00118	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J171_00127	COG0793	Belongs to the peptidase S41A family
J171_00128	COG4942	peptidase
J171_00130	COG2234	aminopeptidase activity
J171_00132	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J171_00133	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J171_00134	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J171_00135	COG1064	alcohol dehydrogenase
J171_00136	COG0493	'glutamate synthase
J171_00137	COG0067	glutamate synthase
J171_00137	COG0069	glutamate synthase activity
J171_00137	COG0070	glutamate synthase
J171_00141	COG2366	antibiotic biosynthetic process
J171_00146	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J171_00149	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
J171_00150	COG0438	transferase activity, transferring glycosyl groups
J171_00150	COG0297	glycogen (starch) synthase activity
J171_00154	COG0367	asparagine synthase
J171_00160	COG1132	(ABC) transporter
J171_00184	COG1111	helicase
J171_00184	COG1205	dead DEAH box helicase
J171_00185	COG1272	protein, Hemolysin III
J171_00188	COG0300	oxidoreductase activity
J171_00189	COG1028	Short-chain dehydrogenase reductase Sdr
J171_00194	COG2249	NAD(P)H dehydrogenase (quinone) activity
J171_00196	COG2963	transposase activity
J171_00205	COG3237	CsbD-like
J171_00214	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J171_00215	COG0477	Major facilitator Superfamily
J171_00223	COG0714	Associated with various cellular activities
J171_00229	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
J171_00231	COG4772	TonB-dependent receptor
J171_00233	COG0662	Cupin 2, conserved barrel domain protein
J171_00234	COG1012	belongs to the aldehyde dehydrogenase family
J171_00239	COG1304	FMN binding
J171_00241	COG4585	Histidine kinase
J171_00242	COG2197	response regulator
J171_00246	COG3710	Transcriptional regulator
J171_00247	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J171_00260	COG2963	transposase activity
J171_00262	COG0366	Alpha amylase catalytic
J171_00263	COG0366	Alpha amylase catalytic
J171_00264	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J171_00268	COG0657	acetylesterase activity
J171_00268	COG2755	lipolytic protein G-D-S-L family
J171_00270	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J171_00273	COG3507	Belongs to the glycosyl hydrolase 43 family
J171_00274	COG1609	Transcriptional regulator
J171_00275	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
J171_00276	COG1028	Short-chain dehydrogenase reductase Sdr
J171_00278	COG2755	lipolytic protein G-D-S-L family
J171_00281	COG3186	Phenylalanine-4-hydroxylase
J171_00282	COG1522	sequence-specific DNA binding
J171_00284	COG1752	Esterase of the alpha-beta hydrolase superfamily
J171_00286	COG1119	ATPase activity
J171_00289	COG1125	glycine betaine transport
J171_00292	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J171_00295	COG1396	sequence-specific DNA binding
J171_00299	COG0489	protein tyrosine kinase activity
J171_00300	COG2062	phosphohistidine phosphatase, SixA
J171_00302	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J171_00311	COG1968	undecaprenyl-diphosphatase activity
J171_00312	COG0174	glutamine synthetase
J171_00313	COG0347	Belongs to the P(II) protein family
J171_00314	COG0004	ammonium transporteR
J171_00315	COG3852	Histidine kinase
J171_00316	COG2204	response regulator
J171_00317	COG2032	superoxide dismutase activity
J171_00318	COG2032	superoxide dismutase activity
J171_00319	COG0346	lactoylglutathione lyase activity
J171_00321	COG0183	Belongs to the thiolase family
J171_00328	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J171_00329	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
J171_00330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J171_00332	COG0028	Belongs to the TPP enzyme family
J171_00333	COG2205	protein histidine kinase activity
J171_00338	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J171_00341	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J171_00343	COG0596	Alpha beta hydrolase
J171_00345	COG0318	PFAM AMP-dependent synthetase and ligase
J171_00347	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J171_00349	COG1181	Belongs to the D-alanine--D-alanine ligase family
J171_00351	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J171_00353	COG0564	pseudouridine synthase activity
J171_00358	COG0339	signal peptide processing
J171_00363	COG0475	glutathione-regulated potassium exporter activity
J171_00364	COG0583	DNA-binding transcription factor activity
J171_00365	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J171_00366	COG2224	Isocitrate lyase
J171_00367	COG3706	GGDEF domain
J171_00374	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J171_00375	COG1960	acyl-CoA dehydrogenase activity
J171_00386	COG0523	cobalamin synthesis protein
J171_00388	COG0697	spore germination
J171_00390	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
J171_00391	COG1846	Transcriptional regulator
J171_00392	COG1764	response to oxidative stress
J171_00397	COG2130	NADP-dependent
J171_00400	COG1187	pseudouridine synthase activity
J171_00403	COG1643	Atp-dependent helicase
J171_00404	COG4807	Protein conserved in bacteria
J171_00405	COG2351	hydroxyisourate hydrolase activity
J171_00406	COG2072	flavoprotein involved in K transport
J171_00410	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J171_00417	COG1957	nucleoside hydrolase
J171_00419	COG2252	PERMEase
J171_00423	COG0084	hydrolase, TatD family'
J171_00426	COG0583	DNA-binding transcription factor activity
J171_00427	COG2814	Major facilitator Superfamily
J171_00430	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J171_00431	COG1902	pentaerythritol trinitrate reductase activity
J171_00435	COG0745	RESPONSE REGULATOR receiver
J171_00436	COG2205	protein histidine kinase activity
J171_00437	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J171_00439	COG1538	Outer membrane efflux protein
J171_00441	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J171_00442	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J171_00443	COG0583	DNA-binding transcription factor activity
J171_00449	COG0702	epimerase
J171_00450	COG1733	regulation of RNA biosynthetic process
J171_00455	COG2963	transposase activity
J171_00457	COG0129	dihydroxy-acid dehydratase activity
J171_00460	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
J171_00471	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J171_00472	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J171_00477	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
J171_00478	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
J171_00480	COG3485	protocatechuate 3,4-dioxygenase
J171_00481	COG3485	protocatechuate 3,4-dioxygenase
J171_00483	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J171_00484	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J171_00486	COG1414	Transcriptional regulator
J171_00490	COG0445	tRNA wobble uridine modification
J171_00498	COG2267	carboxylic ester hydrolase activity
J171_00500	COG0156	8-amino-7-oxononanoate synthase activity
J171_00501	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J171_00502	COG1040	competence protein
J171_00503	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J171_00520	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J171_00534	COG3264	Mechanosensitive ion channel
J171_00534	COG1511	domain protein
J171_00535	COG1368	sulfuric ester hydrolase activity
J171_00536	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J171_00537	COG2354	Protein conserved in bacteria
J171_00538	COG0745	RESPONSE REGULATOR receiver
J171_00538	COG3706	GGDEF domain
J171_00539	COG0297	glycogen (starch) synthase activity
J171_00540	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J171_00541	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J171_00546	COG0702	epimerase
J171_00547	COG1028	Short-chain dehydrogenase reductase Sdr
J171_00553	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J171_00554	COG1028	Short-chain dehydrogenase reductase Sdr
J171_00557	COG0513	Belongs to the DEAD box helicase family
J171_00562	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J171_00564	COG3483	tryptophan 2,3-dioxygenase activity
J171_00565	COG3104	oligopeptide transport
J171_00569	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
J171_00572	COG1320	monovalent cation:proton antiporter activity
J171_00573	COG2212	antiporter activity
J171_00575	COG0651	ATP synthesis coupled electron transport
J171_00576	COG1006	Multisubunit Na H antiporter MnhC subunit
J171_00577	COG2111	Na H antiporter
J171_00577	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J171_00581	COG3179	chitinase
J171_00585	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J171_00586	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
J171_00589	COG0456	acetyltransferase
J171_00590	COG1597	lipid kinase activity
J171_00595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J171_00596	COG0134	indole-3-glycerol-phosphate synthase activity
J171_00598	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J171_00599	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
J171_00601	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
J171_00602	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J171_00603	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J171_00606	COG1051	belongs to the nudix hydrolase family
J171_00613	COG0316	Belongs to the HesB IscA family
J171_00617	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
J171_00620	COG2814	Major facilitator Superfamily
J171_00621	COG0583	DNA-binding transcription factor activity
J171_00622	COG2814	Major facilitator Superfamily
J171_00623	COG1289	transmembrane transporter activity
J171_00624	COG0151	Belongs to the GarS family
J171_00626	COG0138	bifunctional purine biosynthesis protein purh
J171_00627	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J171_00628	COG2267	carboxylic ester hydrolase activity
J171_00629	COG2453	phosphatase
J171_00629	COG0671	phosphoesterase, PA-phosphatase related
J171_00634	COG4589	Belongs to the CDS family
J171_00635	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
J171_00640	COG2264	protein methyltransferase activity
J171_00643	COG0439	Biotin carboxylase
J171_00645	COG0511	ligase activity, forming carbon-carbon bonds
J171_00646	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
J171_00648	COG1324	tolerance protein
J171_00653	COG0300	oxidoreductase activity
J171_00654	COG2356	endonuclease I
J171_00655	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J171_00656	COG0459	protein refolding
J171_00659	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J171_00662	COG3386	PFAM SMP-30 Gluconolaconase
J171_00664	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
J171_00665	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J171_00668	COG0778	Nitroreductase
J171_00669	COG2353	YceI-like domain
J171_00674	COG3052	prosthetic group binding
J171_00678	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
J171_00680	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J171_00682	COG1802	Transcriptional regulator
J171_00692	COG2963	transposase activity
J171_00693	COG4221	oxidoreductase activity
J171_00696	COG4221	oxidoreductase activity
J171_00698	COG0435	Glutathione S-transferase
J171_00703	COG2409	Drug exporters of the RND superfamily
J171_00704	COG0823	Involved in the tonB-independent uptake of proteins
J171_00704	COG1506	peptidase
J171_00706	COG3706	GGDEF domain
J171_00710	COG0697	spore germination
J171_00714	COG1113	amino acid transport
J171_00716	COG0598	Magnesium transport protein CorA
J171_00718	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
J171_00725	COG5001	Diguanylate cyclase
J171_00726	COG0840	transmembrane signaling receptor activity
J171_00727	COG5297	Belongs to the glycosyl hydrolase family 6
J171_00727	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J171_00728	COG0659	secondary active sulfate transmembrane transporter activity
J171_00729	COG3706	GGDEF domain
J171_00732	COG2943	transferase activity, transferring hexosyl groups
J171_00734	COG3275	phosphorelay sensor kinase activity
J171_00736	COG0181	hydroxymethylbilane synthase activity
J171_00741	COG1505	serine-type exopeptidase activity
J171_00742	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J171_00745	COG2832	Protein of unknown function (DUF454)
J171_00747	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J171_00749	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
J171_00750	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
J171_00751	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
J171_00756	COG2226	methyltransferase
J171_00757	COG3300	MHYT domain
J171_00757	COG5001	Diguanylate cyclase
J171_00758	COG0308	aminopeptidase N
J171_00767	COG3284	Transcriptional regulator
J171_00769	COG1077	Cell shape determining protein MreB Mrl
J171_00770	COG1792	Involved in formation and maintenance of cell shape
J171_00773	COG0772	Belongs to the SEDS family
J171_00775	COG2951	lytic endotransglycosylase activity
J171_00776	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J171_00777	COG1686	Belongs to the peptidase S11 family
J171_00779	COG2921	Belongs to the UPF0250 family
J171_00780	COG0321	lipoyl(octanoyl) transferase activity
J171_00781	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J171_00784	COG0583	DNA-binding transcription factor activity
J171_00786	COG1056	cytidyltransferase-related domain
J171_00786	COG1051	belongs to the nudix hydrolase family
J171_00793	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
J171_00794	COG0673	inositol 2-dehydrogenase activity
J171_00795	COG2823	Periplasmic or secreted lipoprotein
J171_00796	COG4251	negative regulation of phosphorylation
J171_00797	COG0784	Response regulator, receiver
J171_00798	COG4191	Histidine kinase
J171_00799	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J171_00800	COG1028	Short-chain dehydrogenase reductase Sdr
J171_00810	COG1459	type II secretion system
J171_00821	COG3250	beta-galactosidase activity
J171_00827	COG1609	Transcriptional regulator
J171_00828	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J171_00829	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J171_00831	COG0617	tRNA 3'-terminal CCA addition
J171_00832	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
J171_00833	COG1012	belongs to the aldehyde dehydrogenase family
J171_00834	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J171_00836	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J171_00840	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J171_00841	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J171_00844	COG2205	protein histidine kinase activity
J171_00845	COG0745	RESPONSE REGULATOR receiver
J171_00850	COG3791	Glutathione-dependent formaldehyde-activating
J171_00852	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J171_00854	COG0697	spore germination
J171_00856	COG0488	(ABC) transporter
J171_00858	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J171_00859	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J171_00861	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J171_00861	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J171_00866	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J171_00867	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J171_00868	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
J171_00872	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
J171_00873	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
J171_00874	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
J171_00875	COG2205	protein histidine kinase activity
J171_00876	COG0745	RESPONSE REGULATOR receiver
J171_00879	COG0277	FAD linked oxidase domain protein
J171_00880	COG1988	membrane-bound metal-dependent
J171_00881	COG0792	nuclease activity
J171_00888	COG2001	Belongs to the MraZ family
J171_00889	COG0275	rRNA processing
J171_00890	COG3116	cell division
J171_00892	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J171_00893	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J171_00894	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J171_00896	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J171_00897	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J171_00898	COG1181	Belongs to the D-alanine--D-alanine ligase family
J171_00899	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J171_00902	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
J171_00904	COG0739	heme binding
J171_00905	COG0653	protein targeting
J171_00906	COG0494	nUDIX hydrolase
J171_00908	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J171_00911	COG3321	synthase
J171_00911	COG1028	Short-chain dehydrogenase reductase Sdr
J171_00911	COG0604	alcohol dehydrogenase
J171_00915	COG0366	Alpha amylase catalytic
J171_00921	COG2226	methyltransferase
J171_00922	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J171_00925	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
J171_00931	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J171_00933	COG4106	trans-aconitate 2-methyltransferase activity
J171_00934	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J171_00937	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J171_00938	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
J171_00939	COG0667	Aldo Keto reductase
J171_00941	COG4771	TonB-dependent receptor
J171_00946	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J171_00947	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
J171_00949	COG2175	clavaminate synthase activity
J171_00951	COG4181	ATPase activity
J171_00954	COG0642	Histidine kinase
J171_00956	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J171_00960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J171_00961	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J171_00964	COG3829	transcription factor binding
J171_00966	COG1116	anion transmembrane transporter activity
J171_00967	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J171_00969	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J171_00970	COG0431	NADPH-dependent FMN reductase
J171_00975	COG0747	negative chemotaxis
J171_00980	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J171_00981	COG2967	ApaG domain
J171_00982	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J171_00983	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
J171_00984	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J171_00985	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
J171_00988	COG0123	including yeast histone deacetylase and acetoin utilization protein
J171_00989	COG2096	Adenosyltransferase
J171_00991	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J171_00992	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J171_00998	COG3384	dioxygenase
J171_00999	COG0583	DNA-binding transcription factor activity
J171_01002	COG1024	Enoyl-CoA hydratase
J171_01006	COG3386	PFAM SMP-30 Gluconolaconase
J171_01008	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
J171_01011	COG0697	spore germination
J171_01012	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J171_01015	COG0745	RESPONSE REGULATOR receiver
J171_01015	COG3706	GGDEF domain
J171_01016	COG5002	protein histidine kinase activity
J171_01016	COG2205	protein histidine kinase activity
J171_01016	COG0784	Response regulator, receiver
J171_01017	COG2197	response regulator
J171_01019	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J171_01021	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J171_01022	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J171_01023	COG0583	DNA-binding transcription factor activity
J171_01024	COG3634	alkyl hydroperoxide reductase activity
J171_01026	COG2890	protein-(glutamine-N5) methyltransferase activity
J171_01030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J171_01030	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J171_01036	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J171_01041	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J171_01042	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
J171_01045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J171_01046	COG1404	Belongs to the peptidase S8 family
J171_01047	COG1404	Belongs to the peptidase S8 family
J171_01048	COG1404	Belongs to the peptidase S8 family
J171_01049	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J171_01055	COG1295	ribonuclease BN
J171_01056	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J171_01057	COG1254	Belongs to the acylphosphatase family
J171_01060	COG0521	Mo-molybdopterin cofactor biosynthetic process
J171_01062	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J171_01063	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
J171_01065	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
J171_01066	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J171_01068	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J171_01069	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J171_01070	COG0193	aminoacyl-tRNA hydrolase activity
J171_01071	COG0012	GTP binding
J171_01075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J171_01077	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J171_01078	COG0250	Participates in transcription elongation, termination and antitermination
J171_01079	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J171_01080	COG0081	regulation of translation
J171_01081	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J171_01082	COG0222	ribosome binding
J171_01084	COG0085	RNA polymerase activity
J171_01085	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J171_01086	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J171_01087	COG0049	tRNA binding
J171_01088	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J171_01089	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J171_01090	COG0051	transcription antitermination factor activity, RNA binding
J171_01091	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J171_01092	COG0088	Forms part of the polypeptide exit tunnel
J171_01093	COG0089	rRNA binding
J171_01094	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J171_01095	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J171_01096	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J171_01097	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J171_01098	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J171_01099	COG0255	Belongs to the universal ribosomal protein uL29 family
J171_01100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J171_01101	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J171_01102	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J171_01103	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J171_01104	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J171_01105	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J171_01106	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J171_01107	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J171_01108	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J171_01109	COG1841	ribosomal large subunit assembly
J171_01110	COG0200	Binds to the 23S rRNA
J171_01111	COG0201	protein transport
J171_01112	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J171_01113	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J171_01114	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J171_01115	COG0202	RNA polymerase activity
J171_01116	COG0203	ribosomal protein L17
J171_01117	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
J171_01119	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
J171_01121	COG0154	amidase activity
J171_01124	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J171_01125	COG0039	L-malate dehydrogenase activity
J171_01126	COG0625	glutathione transferase activity
J171_01128	COG1902	pentaerythritol trinitrate reductase activity
J171_01128	COG0446	pyridine nucleotide-disulphide oxidoreductase
J171_01129	COG0604	alcohol dehydrogenase
J171_01134	COG0156	8-amino-7-oxononanoate synthase activity
J171_01135	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
J171_01136	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
J171_01137	COG4208	sulfate ABC transporter
J171_01138	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J171_01140	COG1063	alcohol dehydrogenase
J171_01145	COG0406	alpha-ribazole phosphatase activity
J171_01146	COG0285	dihydrofolate synthase activity
J171_01150	COG2833	Protein of unknown function (DUF455)
J171_01152	COG3291	Pkd domain containing protein
J171_01154	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J171_01156	COG0671	phosphoesterase, PA-phosphatase related
J171_01157	COG0438	transferase activity, transferring glycosyl groups
J171_01159	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J171_01162	COG4783	chaperone-mediated protein folding
J171_01165	COG0473	3-isopropylmalate dehydrogenase activity
J171_01172	COG2963	transposase activity
J171_01195	COG2963	transposase activity
J171_01199	COG3852	Histidine kinase
J171_01202	COG0544	peptidyl-prolyl cis-trans isomerase activity
J171_01203	COG0740	serine-type endopeptidase activity
J171_01204	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J171_01210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J171_01213	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J171_01215	COG0328	RNA-DNA hybrid ribonuclease activity
J171_01216	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J171_01217	COG0631	protein serine/threonine phosphatase activity
J171_01220	COG0859	PFAM glycosyl transferase family 9
J171_01221	COG3642	lipopolysaccharide core region biosynthetic process
J171_01222	COG1234	tRNA 3'-trailer cleavage
J171_01223	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J171_01224	COG0315	cyclic pyranopterin monophosphate synthase activity
J171_01225	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
J171_01226	COG0314	molybdopterin synthase activity
J171_01229	COG2963	transposase activity
J171_01237	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
J171_01238	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J171_01239	COG0537	adenosine 5'-monophosphoramidase activity
J171_01243	COG0714	Associated with various cellular activities
J171_01247	COG0424	maF-like protein
J171_01248	COG1399	metal-binding, possibly nucleic acid-binding protein
J171_01249	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J171_01250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J171_01253	COG1028	Short-chain dehydrogenase reductase Sdr
J171_01254	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J171_01256	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J171_01257	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J171_01262	COG3829	transcription factor binding
J171_01266	COG3609	addiction module antidote protein, CC2985 family
J171_01271	COG2373	Large extracellular alpha-helical protein
J171_01274	COG4953	penicillin-binding protein 1C
J171_01276	COG0678	peroxiredoxin activity
J171_01282	COG0330	HflC and HflK could
J171_01283	COG0330	HflC and HflK could
J171_01285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J171_01286	COG0308	aminopeptidase N
J171_01288	COG1028	Short-chain dehydrogenase reductase Sdr
J171_01289	COG1309	transcriptional regulator
J171_01302	COG0328	RNA-DNA hybrid ribonuclease activity
J171_01302	COG0406	alpha-ribazole phosphatase activity
J171_01303	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J171_01305	COG3387	PFAM Glycoside hydrolase 15-related
J171_01306	COG1028	Short-chain dehydrogenase reductase Sdr
J171_01307	COG3537	Alpha-1,2-mannosidase
J171_01311	COG0492	ferredoxin-NADP+ reductase activity
J171_01316	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J171_01317	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J171_01318	COG2080	2 iron, 2 sulfur cluster binding
J171_01325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J171_01328	COG0587	DNA-directed DNA polymerase activity
J171_01331	COG1297	OPT oligopeptide transporter protein
J171_01334	COG1506	peptidase
J171_01334	COG0823	Involved in the tonB-independent uptake of proteins
J171_01337	COG1917	Cupin 2, conserved barrel domain protein
J171_01337	COG2207	Transcriptional regulator
J171_01342	COG0753	catalase activity
J171_01343	COG0656	L-ascorbic acid biosynthetic process
J171_01345	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J171_01345	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J171_01348	COG2814	Major facilitator Superfamily
J171_01351	COG2194	sulfuric ester hydrolase activity
J171_01354	COG0745	RESPONSE REGULATOR receiver
J171_01355	COG0642	Histidine kinase
J171_01357	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
J171_01358	COG2894	cell division
J171_01359	COG0850	regulation of cytokinetic process
J171_01361	COG4585	Histidine kinase
J171_01362	COG2197	response regulator
J171_01365	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
J171_01370	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
J171_01372	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
J171_01377	COG1946	Acyl-CoA thioesterase
J171_01380	COG0824	Thioesterase
J171_01381	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J171_01382	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J171_01383	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J171_01384	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J171_01385	COG0268	Binds directly to 16S ribosomal RNA
J171_01387	COG0196	riboflavin kinase activity
J171_01388	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J171_01389	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J171_01390	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J171_01393	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J171_01394	COG1845	cytochrome c oxidase, subunit III
J171_01395	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
J171_01398	COG3152	Membrane
J171_01400	COG2207	Transcriptional regulator
J171_01401	COG0326	Molecular chaperone. Has ATPase activity
J171_01403	COG1366	Belongs to the anti-sigma-factor antagonist family
J171_01404	COG1366	Belongs to the anti-sigma-factor antagonist family
J171_01405	COG2172	sigma factor antagonist activity
J171_01410	COG4771	TonB-dependent receptor
J171_01412	COG5507	3-demethylubiquinone-9 3-methyltransferase
J171_01413	COG2205	protein histidine kinase activity
J171_01415	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J171_01416	COG3850	Histidine kinase
J171_01416	COG3437	response regulator, receiver
J171_01416	COG2205	protein histidine kinase activity
J171_01416	COG4999	Histidine kinase
J171_01417	COG0784	Response regulator, receiver
J171_01417	COG4191	Histidine kinase
J171_01422	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J171_01423	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J171_01425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J171_01426	COG0228	four-way junction DNA binding
J171_01427	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J171_01428	COG0336	Belongs to the RNA methyltransferase TrmD family
J171_01429	COG0335	large ribosomal subunit rRNA binding
J171_01430	COG0534	Mate efflux family protein
J171_01431	COG0534	Mate efflux family protein
J171_01435	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
J171_01437	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J171_01440	COG3209	COG3209 Rhs family protein
J171_01444	COG3250	beta-galactosidase activity
J171_01445	COG3867	Arabinogalactan endo-beta-1,4-galactanase
J171_01449	COG1960	acyl-CoA dehydrogenase activity
J171_01450	COG1024	Enoyl-CoA hydratase
J171_01454	COG1024	Enoyl-CoA hydratase
J171_01454	COG1250	3-hydroxyacyl-CoA dehydrogenase
J171_01457	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J171_01458	COG0481	GTPase activity
J171_01461	COG0571	ribonuclease III activity
J171_01462	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J171_01463	COG1381	Involved in DNA repair and RecF pathway recombination
J171_01465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J171_01467	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J171_01468	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
J171_01469	COG3046	protein related to deoxyribodipyrimidine photolyase
J171_01470	COG1472	Belongs to the glycosyl hydrolase 3 family
J171_01472	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
J171_01473	COG1278	Cold shock
J171_01474	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J171_01476	COG1201	RNA secondary structure unwinding
J171_01477	COG1793	dna ligase
J171_01479	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J171_01479	COG1793	dna ligase
J171_01482	COG3706	GGDEF domain
J171_01482	COG0745	RESPONSE REGULATOR receiver
J171_01485	COG0183	Belongs to the thiolase family
J171_01489	COG1451	nucleotide metabolic process
J171_01490	COG5487	UPF0391 membrane protein
J171_01492	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J171_01495	COG1077	Cell shape determining protein MreB Mrl
J171_01496	COG1047	Peptidyl-prolyl cis-trans
J171_01498	COG2824	Alkylphosphonate utilization operon protein PhnA
J171_01499	COG1902	pentaerythritol trinitrate reductase activity
J171_01500	COG2814	Major facilitator Superfamily
J171_01507	COG0392	lysyltransferase activity
J171_01507	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
J171_01510	COG0251	oxidation-reduction process
J171_01511	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J171_01514	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J171_01519	COG1595	DNA-templated transcription, initiation
J171_01522	COG2878	Part of a membrane complex involved in electron transport
J171_01524	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J171_01524	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J171_01527	COG1131	(ABC) transporter
J171_01528	COG0346	lactoylglutathione lyase activity
J171_01529	COG0833	amino acid
J171_01530	COG2040	homocysteine
J171_01532	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J171_01536	COG1695	Transcriptional regulator
J171_01543	COG0825	malonyl-CoA metabolic process
J171_01545	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J171_01546	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J171_01547	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J171_01548	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J171_01549	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J171_01552	COG0750	zinc metalloprotease
J171_01553	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J171_01554	COG0575	Belongs to the CDS family
J171_01555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J171_01556	COG0233	cytoplasmic translational termination
J171_01557	COG0528	UMP kinase activity
J171_01558	COG3706	GGDEF domain
J171_01558	COG0745	RESPONSE REGULATOR receiver
J171_01559	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J171_01560	COG0052	Belongs to the universal ribosomal protein uS2 family
J171_01567	COG0024	Methionine aminopeptidase
J171_01568	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
J171_01570	COG1393	Belongs to the ArsC family
J171_01571	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J171_01572	COG0367	asparagine synthase
J171_01574	COG4774	siderophore transport
J171_01578	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J171_01584	COG1566	PFAM secretion protein HlyD family protein
J171_01585	COG2814	Major facilitator Superfamily
J171_01589	COG3104	oligopeptide transport
J171_01595	COG0339	signal peptide processing
J171_01596	COG0386	Belongs to the glutathione peroxidase family
J171_01607	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J171_01608	COG0084	hydrolase, TatD family'
J171_01611	COG1960	acyl-CoA dehydrogenase activity
J171_01614	COG0367	asparagine synthase
J171_01616	COG0305	Participates in initiation and elongation during chromosome replication
J171_01617	COG0415	Belongs to the DNA photolyase family
J171_01620	COG0583	DNA-binding transcription factor activity
J171_01627	COG3706	GGDEF domain
J171_01629	COG3706	GGDEF domain
J171_01656	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J171_01659	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J171_01661	COG0497	DNA recombination
J171_01662	COG1420	regulation of RNA biosynthetic process
J171_01663	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J171_01664	COG0443	Heat shock 70 kDa protein
J171_01665	COG0484	heat shock protein binding
J171_01667	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
J171_01674	COG0583	DNA-binding transcription factor activity
J171_01675	COG1132	(ABC) transporter
J171_01682	COG2850	peptidyl-arginine hydroxylation
J171_01686	COG1253	flavin adenine dinucleotide binding
J171_01692	COG1131	(ABC) transporter
J171_01693	COG1725	Transcriptional regulator
J171_01695	COG0386	Belongs to the glutathione peroxidase family
J171_01698	COG2900	Belongs to the SlyX family
J171_01703	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J171_01705	COG1410	methionine synthase
J171_01705	COG0646	methionine synthase
J171_01706	COG1410	methionine synthase
J171_01706	COG0646	methionine synthase
J171_01708	COG1960	acyl-CoA dehydrogenase activity
J171_01711	COG0557	exoribonuclease II activity
J171_01713	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J171_01714	COG3706	GGDEF domain
J171_01715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J171_01717	COG0704	Plays a role in the regulation of phosphate uptake
J171_01718	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J171_01719	COG0581	inorganic phosphate transmembrane transporter activity
J171_01720	COG0573	inorganic phosphate transmembrane transporter activity
J171_01721	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J171_01726	COG0659	secondary active sulfate transmembrane transporter activity
J171_01727	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J171_01729	COG1024	Enoyl-CoA hydratase
J171_01731	COG0494	nUDIX hydrolase
J171_01739	COG0116	Belongs to the methyltransferase superfamily
J171_01739	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J171_01740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J171_01744	COG2925	Exonuclease
J171_01745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J171_01746	COG3844	kynureninase activity
J171_01748	COG0662	Cupin 2, conserved barrel domain protein
J171_01749	COG0288	reversible hydration of carbon dioxide
J171_01761	COG2808	Putative FMN-binding domain
J171_01765	COG0017	Asparaginyl-tRNA synthetase
J171_01766	COG0316	Belongs to the HesB IscA family
J171_01767	COG0360	Binds together with S18 to 16S ribosomal RNA
J171_01768	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J171_01769	COG0359	binds to the 23S rRNA
J171_01771	COG3115	cell septum assembly
J171_01773	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J171_01774	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J171_01775	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
J171_01777	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
J171_01779	COG4993	Dehydrogenase
J171_01781	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
J171_01783	COG2986	histidine ammonia-lyase
J171_01784	COG1228	amidohydrolase
J171_01792	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
J171_01793	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J171_01794	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
J171_01795	COG0077	Prephenate dehydratase
J171_01795	COG1605	Chorismate mutase
J171_01796	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J171_01799	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J171_01800	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J171_01801	COG0583	DNA-binding transcription factor activity
J171_01806	COG2963	transposase activity
J171_01812	COG0840	transmembrane signaling receptor activity
J171_01816	COG0745	RESPONSE REGULATOR receiver
J171_01817	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
J171_01818	COG0784	Response regulator, receiver
J171_01818	COG4191	Histidine kinase
J171_01821	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J171_01823	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
J171_01825	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J171_01828	COG1595	DNA-templated transcription, initiation
J171_01839	COG2244	polysaccharide biosynthetic process
J171_01845	COG2264	protein methyltransferase activity
J171_01847	COG0438	transferase activity, transferring glycosyl groups
J171_01850	COG1136	(ABC) transporter
J171_01852	COG0477	Major facilitator Superfamily
J171_01853	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J171_01856	COG1253	flavin adenine dinucleotide binding
J171_01858	COG0306	phosphate transporter
J171_01863	COG0504	CTP synthase activity
J171_01864	COG2877	3-deoxy-8-phosphooctulonate synthase activity
J171_01866	COG0148	phosphopyruvate hydratase activity
J171_01867	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
J171_01868	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J171_01869	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J171_01870	COG0585	pseudouridine synthase activity
J171_01871	COG2840	Smr protein MutS2
J171_01872	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
J171_01873	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J171_01874	COG1238	metal cluster binding
J171_01878	COG1534	Rna-binding protein
J171_01879	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
J171_01880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J171_01881	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J171_01882	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J171_01883	COG1923	regulation of RNA biosynthetic process
J171_01884	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J171_01885	COG1546	Belongs to the CinA family
J171_01887	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J171_01888	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J171_01889	COG2137	regulation of response to DNA damage stimulus
J171_01890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J171_01891	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
J171_01894	COG1741	Belongs to the pirin family
J171_01895	COG0583	DNA-binding transcription factor activity
J171_01900	COG0352	thiamine-phosphate diphosphorylase activity
J171_01900	COG0351	phosphomethylpyrimidine kinase
J171_01903	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
J171_01904	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J171_01907	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J171_01909	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
J171_01910	COG3734	2-keto-3-deoxy-galactonokinase
J171_01912	COG4948	Mandelate Racemase Muconate Lactonizing
J171_01913	COG0800	Aldolase
J171_01921	COG1501	Belongs to the glycosyl hydrolase 31 family
J171_01923	COG1070	Carbohydrate kinase
J171_01924	COG2115	Belongs to the xylose isomerase family
J171_01925	COG0477	Major facilitator Superfamily
J171_01928	COG0860	N-Acetylmuramoyl-L-alanine amidase
J171_01929	COG1469	GTP cyclohydrolase I activity
J171_01935	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J171_01936	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
J171_01937	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
J171_01938	COG0166	Belongs to the GPI family
J171_01942	COG1472	Belongs to the glycosyl hydrolase 3 family
J171_01944	COG5001	Diguanylate cyclase
J171_01944	COG2203	Gaf domain
J171_01944	COG3706	GGDEF domain
J171_01944	COG4251	negative regulation of phosphorylation
J171_01945	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J171_01946	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
J171_01948	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J171_01949	COG0671	phosphoesterase, PA-phosphatase related
J171_01951	COG1794	racemase activity, acting on amino acids and derivatives
J171_01952	COG0697	spore germination
J171_01953	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J171_01954	COG0167	dihydroorotate dehydrogenase activity
J171_01957	COG1012	belongs to the aldehyde dehydrogenase family
J171_01960	COG1215	transferase activity, transferring glycosyl groups
J171_01961	COG1649	PFAM Uncharacterised BCR, COG1649
J171_01961	COG0726	polysaccharide deacetylase
J171_01964	COG3210	domain, Protein
J171_01965	COG3210	domain, Protein
J171_01974	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J171_01975	COG0124	histidyl-tRNA synthetase
J171_01977	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J171_01978	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J171_01979	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J171_01980	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
J171_01980	COG0131	Imidazoleglycerol-phosphate dehydratase
J171_01981	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J171_01982	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J171_01983	COG0107	imidazoleglycerol-phosphate synthase activity
J171_01984	COG0140	phosphoribosyl-ATP diphosphatase activity
J171_01984	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J171_01987	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
J171_01988	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
J171_01989	COG0235	Class ii aldolase
J171_01990	COG0531	amino acid
J171_01991	COG0531	amino acid
J171_01993	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J171_01994	COG0277	FAD linked oxidase domain protein
J171_01998	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J171_02007	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J171_02008	COG2258	MOSC domain
J171_02009	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J171_02010	COG0505	Belongs to the CarA family
J171_02012	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J171_02013	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J171_02015	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J171_02023	COG3279	Response regulator of the LytR AlgR family
J171_02024	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
J171_02025	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J171_02027	COG0784	Response regulator, receiver
J171_02027	COG2205	protein histidine kinase activity
J171_02027	COG2198	Histidine kinase
J171_02028	COG1024	Enoyl-CoA hydratase
J171_02029	COG0318	PFAM AMP-dependent synthetase and ligase
J171_02035	COG2267	carboxylic ester hydrolase activity
J171_02037	COG2201	protein-glutamate methylesterase activity
J171_02038	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
J171_02040	COG0840	transmembrane signaling receptor activity
J171_02041	COG0840	transmembrane signaling receptor activity
J171_02042	COG0840	transmembrane signaling receptor activity
J171_02043	COG0840	transmembrane signaling receptor activity
J171_02044	COG0840	transmembrane signaling receptor activity
J171_02045	COG0840	transmembrane signaling receptor activity
J171_02046	COG0840	transmembrane signaling receptor activity
J171_02048	COG0840	transmembrane signaling receptor activity
J171_02049	COG0840	transmembrane signaling receptor activity
J171_02049	COG0840	transmembrane signaling receptor activity
J171_02051	COG0840	transmembrane signaling receptor activity
J171_02052	COG0643	Histidine kinase
J171_02052	COG2198	Histidine kinase
J171_02053	COG0745	RESPONSE REGULATOR receiver
J171_02055	COG0835	chemotaxis
J171_02056	COG1192	Involved in chromosome partitioning
J171_02057	COG1360	Flagellar Motor Protein
J171_02058	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
J171_02071	COG2963	transposase activity
J171_02077	COG0641	radical SAM
J171_02080	COG0643	Histidine kinase
J171_02080	COG2198	Histidine kinase
J171_02084	COG0455	bacterial-type flagellum organization
J171_02086	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J171_02089	COG5001	Diguanylate cyclase
J171_02089	COG3300	MHYT domain
J171_02090	COG3300	MHYT domain
J171_02090	COG5001	Diguanylate cyclase
J171_02091	COG1684	flagellar biosynthetic protein fliR
J171_02092	COG1987	bacterial-type flagellum assembly
J171_02095	COG3190	flagellar
J171_02105	COG1677	Flagellar hook-basal body complex protein FliE
J171_02112	COG1028	Short-chain dehydrogenase reductase Sdr
J171_02113	COG1028	Short-chain dehydrogenase reductase Sdr
J171_02114	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J171_02117	COG2204	response regulator
J171_02118	COG2201	protein-glutamate methylesterase activity
J171_02124	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
J171_02125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J171_02126	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J171_02128	COG3951	Flagellar rod assembly protein muramidase FlgJ
J171_02128	COG1705	Flagellar rod assembly protein muramidase FlgJ
J171_02129	COG1706	bacterial-type flagellum-dependent cell motility
J171_02130	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
J171_02131	COG4786	Flagellar basal body rod
J171_02132	COG4787	bacterial-type flagellum-dependent cell motility
J171_02133	COG1749	Flagellar hook protein flgE
J171_02134	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
J171_02135	COG1558	bacterial-type flagellum-dependent cell motility
J171_02137	COG0835	chemotaxis
J171_02137	COG0784	Response regulator, receiver
J171_02141	COG5002	protein histidine kinase activity
J171_02147	COG2915	High frequency lysogenization protein hflD homolog
J171_02148	COG0482	sulfurtransferase activity
J171_02150	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
J171_02151	COG0542	response to heat
J171_02152	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J171_02153	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
J171_02155	COG0492	ferredoxin-NADP+ reductase activity
J171_02156	COG1674	ftsk spoiiie
J171_02158	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
J171_02160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J171_02162	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J171_02164	COG0183	Belongs to the thiolase family
J171_02165	COG1250	3-hydroxyacyl-CoA dehydrogenase
J171_02165	COG1024	Enoyl-CoA hydratase
J171_02167	COG0105	UTP biosynthetic process
J171_02168	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J171_02170	COG1426	Protein conserved in bacteria
J171_02172	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J171_02173	COG1160	GTP binding
J171_02174	COG0303	'Molybdopterin
J171_02175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J171_02182	COG0708	Exodeoxyribonuclease III
J171_02184	COG0303	'Molybdopterin
J171_02185	COG0746	molybdenum cofactor guanylyltransferase activity
J171_02188	COG1914	H( )-stimulated, divalent metal cation uptake system
J171_02189	COG1321	iron dependent repressor
J171_02190	COG0590	tRNA wobble adenosine to inosine editing
J171_02191	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
J171_02192	COG0668	transmembrane transport
J171_02194	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
J171_02197	COG1028	Short-chain dehydrogenase reductase Sdr
J171_02198	COG1183	phosphatidylcholine synthase activity
J171_02200	COG3243	poly(R)-hydroxyalkanoic acid synthase
J171_02203	COG0723	plastoquinol--plastocyanin reductase activity
J171_02203	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J171_02205	COG2183	response to ionizing radiation
J171_02206	COG0784	Response regulator, receiver
J171_02206	COG2205	protein histidine kinase activity
J171_02219	COG0800	Aldolase
J171_02220	COG0129	dihydroxy-acid dehydratase activity
J171_02221	COG0363	glucosamine-6-phosphate deaminase activity
J171_02222	COG0837	glucose binding
J171_02223	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J171_02228	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
J171_02231	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J171_02232	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
J171_02234	COG4591	ABC-type transport system involved in lipoprotein release permease component
J171_02235	COG1136	(ABC) transporter
J171_02238	COG0811	peptide transport
J171_02240	COG1132	(ABC) transporter
J171_02241	COG1663	tetraacyldisaccharide 4'-kinase activity
J171_02242	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
J171_02243	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J171_02245	COG0322	excinuclease ABC activity
J171_02246	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J171_02250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J171_02251	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J171_02255	COG2963	transposase activity
J171_02256	COG0582	viral genome integration into host DNA
J171_02258	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
J171_02264	COG1530	ribonuclease E activity
J171_02266	COG3064	Membrane
J171_02267	COG0428	transporter
J171_02269	COG2154	pterin-4-alpha-carbinolamine dehydratase
J171_02270	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
J171_02270	COG0316	Belongs to the HesB IscA family
J171_02281	COG1028	Short-chain dehydrogenase reductase Sdr
J171_02286	COG2963	transposase activity
J171_02288	COG1238	metal cluster binding
J171_02294	COG3279	Response regulator of the LytR AlgR family
J171_02302	COG4566	intracellular signal transduction
J171_02304	COG5001	Diguanylate cyclase
J171_02307	COG3685	Protein conserved in bacteria
J171_02311	COG1648	precorrin-2 dehydrogenase activity
J171_02311	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J171_02314	COG2814	Major facilitator Superfamily
J171_02317	COG1335	isochorismatase
J171_02320	COG2197	response regulator
J171_02323	COG0583	DNA-binding transcription factor activity
J171_02324	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J171_02325	COG3002	Belongs to the UPF0753 family
J171_02327	COG2963	transposase activity
J171_02328	COG1396	sequence-specific DNA binding
J171_02329	COG5489	Protein of unknown function (DUF736)
J171_02330	COG2003	Belongs to the UPF0758 family
J171_02335	COG0582	viral genome integration into host DNA
J171_02338	COG4774	siderophore transport
J171_02342	COG2336	PFAM SpoVT AbrB
J171_02347	COG4206	TonB-dependent receptor
J171_02352	COG2273	Hydrolase Family 16
J171_02352	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
J171_02357	COG2274	protein secretion by the type I secretion system
J171_02359	COG1192	Involved in chromosome partitioning
J171_02367	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J171_02368	COG0270	DNA (cytosine-5-)-methyltransferase activity
J171_02380	COG4804	nuclease activity
J171_02381	COG2963	transposase activity
J171_02383	COG5006	permease, DMT superfamily
J171_02386	COG2249	NAD(P)H dehydrogenase (quinone) activity
J171_02388	COG3938	Belongs to the proline racemase family
J171_02389	COG0655	NAD(P)H dehydrogenase (quinone) activity
J171_02391	COG2807	transmembrane transport
J171_02392	COG2207	Transcriptional regulator
J171_02422	COG0210	DNA helicase
J171_02438	COG2084	Dehydrogenase
J171_02443	COG2003	Belongs to the UPF0758 family
J171_02450	COG0582	viral genome integration into host DNA
J171_02451	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J171_02451	COG0519	Catalyzes the synthesis of GMP from XMP
J171_02453	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J171_02455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J171_02455	COG0475	glutathione-regulated potassium exporter activity
J171_02456	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J171_02458	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J171_02459	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
J171_02461	COG0776	regulation of translation
J171_02462	COG0539	negative regulation of cytoplasmic translation
J171_02463	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J171_02464	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J171_02467	COG2957	Belongs to the agmatine deiminase family
J171_02468	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J171_02473	COG0395	ABC-type sugar transport system, permease component
J171_02474	COG1175	transmembrane transport
J171_02480	COG2350	Protein conserved in bacteria
J171_02481	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
J171_02482	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J171_02483	COG1187	pseudouridine synthase activity
J171_02487	COG0436	Aminotransferase
J171_02488	COG4133	protoheme IX ABC transporter activity
J171_02492	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
J171_02493	COG1138	Cytochrome C-type biogenesis protein
J171_02497	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J171_02498	COG1278	Cold shock
J171_02499	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
J171_02500	COG4988	ABC transporter
J171_02502	COG1294	oxidase, subunit
J171_02507	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J171_02508	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J171_02510	COG0165	Argininosuccinate lyase
J171_02511	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J171_02513	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J171_02516	COG0137	argininosuccinate synthase activity
J171_02517	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J171_02519	COG0215	cysteine-tRNA ligase activity
J171_02520	COG2166	iron-sulfur cluster assembly
J171_02522	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J171_02523	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J171_02524	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J171_02529	COG4302	ethanolamine ammonia-lyase activity
J171_02535	COG2963	transposase activity
J171_02541	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J171_02542	COG0402	S-adenosylhomocysteine deaminase activity
J171_02544	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J171_02545	COG1509	lysine 2,3-aminomutase activity
J171_02546	COG3300	MHYT domain
J171_02546	COG5001	Diguanylate cyclase
J171_02549	COG0483	inositol monophosphate 1-phosphatase activity
J171_02554	COG0513	Belongs to the DEAD box helicase family
J171_02555	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J171_02556	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
J171_02558	COG0625	glutathione transferase activity
J171_02560	COG4681	YaeQ
J171_02561	COG2081	HI0933 family
J171_02563	COG0501	Belongs to the peptidase M48B family
J171_02564	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J171_02565	COG1028	Short-chain dehydrogenase reductase Sdr
J171_02569	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J171_02570	COG0860	N-Acetylmuramoyl-L-alanine amidase
J171_02571	COG0802	atpase or kinase
J171_02572	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J171_02572	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J171_02573	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J171_02574	COG1570	exodeoxyribonuclease VII activity
J171_02576	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J171_02615	COG0835	chemotaxis
J171_02616	COG0840	transmembrane signaling receptor activity
J171_02617	COG2094	Belongs to the DNA glycosylase MPG family
J171_02618	COG1201	RNA secondary structure unwinding
J171_02621	COG2969	positive regulation of protein catabolic process
J171_02622	COG0625	glutathione transferase activity
J171_02623	COG2857	Cytochrome c1
J171_02624	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J171_02625	COG0723	plastoquinol--plastocyanin reductase activity
J171_02626	COG0741	lytic transglycosylase activity
J171_02629	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J171_02630	COG1702	phosphate starvation-inducible protein PhoH
J171_02632	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J171_02634	COG4535	Mg2 and Co2 transporter CorC
J171_02637	COG1012	belongs to the aldehyde dehydrogenase family
J171_02638	COG1177	transmembrane transport
J171_02639	COG1176	ABC-type spermidine putrescine transport system, permease component I
J171_02640	COG3842	ATPase activity
J171_02644	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
J171_02647	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J171_02648	COG0174	glutamine synthetase
J171_02649	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J171_02650	COG0745	RESPONSE REGULATOR receiver
J171_02650	COG3706	GGDEF domain
J171_02651	COG2703	oxygen carrier activity
J171_02652	COG0477	Major facilitator Superfamily
J171_02654	COG0243	molybdopterin cofactor binding
J171_02655	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
J171_02659	COG2733	membrane
J171_02660	COG5002	protein histidine kinase activity
J171_02660	COG0784	Response regulator, receiver
J171_02660	COG2205	protein histidine kinase activity
J171_02662	COG0477	Major facilitator Superfamily
J171_02663	COG2902	Dehydrogenase
J171_02665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J171_02666	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J171_02667	COG1609	Transcriptional regulator
J171_02668	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J171_02668	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J171_02669	COG1105	Belongs to the carbohydrate kinase PfkB family
J171_02670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J171_02670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J171_02678	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J171_02680	COG1862	Preprotein translocase
J171_02681	COG0343	queuine tRNA-ribosyltransferase activity
J171_02682	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
J171_02690	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
J171_02691	COG3291	Pkd domain containing protein
J171_02692	COG0405	Gamma-glutamyltransferase
J171_02693	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J171_02696	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J171_02697	COG0742	ribosomal rna small subunit methyltransferase
J171_02698	COG0326	Molecular chaperone. Has ATPase activity
J171_02714	COG0531	amino acid
J171_02717	COG0006	proline dipeptidase activity
J171_02719	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J171_02722	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J171_02723	COG3938	Belongs to the proline racemase family
J171_02725	COG0552	protein localization to endoplasmic reticulum
J171_02726	COG1194	a g-specific adenine glycosylase
J171_02727	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
J171_02728	COG4191	Histidine kinase
J171_02728	COG0784	Response regulator, receiver
J171_02731	COG0322	excinuclease ABC activity
J171_02734	COG3040	lipid binding
J171_02736	COG1960	acyl-CoA dehydrogenase activity
J171_02738	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J171_02742	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J171_02743	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J171_02744	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J171_02751	COG0438	transferase activity, transferring glycosyl groups
J171_02752	COG0438	transferase activity, transferring glycosyl groups
J171_02761	COG0776	regulation of translation
J171_02762	COG0072	phenylalanine-tRNA ligase activity
J171_02762	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J171_02763	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J171_02764	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J171_02765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J171_02767	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J171_02768	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J171_02773	COG1082	Xylose isomerase domain protein TIM barrel
J171_02777	COG0366	Alpha amylase catalytic
J171_02779	COG2963	transposase activity
J171_02780	COG2801	Transposase and inactivated derivatives
J171_02789	COG3702	type iv secretory pathway
J171_02793	COG2948	multi-organism process
J171_02797	COG3505	Type IV secretory pathway VirD4
J171_02800	COG0556	nucleotide-excision repair
J171_02809	COG2963	transposase activity
J171_02819	COG4695	Portal protein
J171_02828	COG3179	chitinase
J171_02839	COG2963	transposase activity
J171_02844	COG3275	phosphorelay sensor kinase activity
J171_02845	COG1611	Belongs to the LOG family
J171_02847	COG2095	MarC family integral membrane protein
J171_02849	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J171_02850	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J171_02856	COG1185	polyribonucleotide nucleotidyltransferase activity
J171_02857	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J171_02858	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J171_02859	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J171_02860	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J171_02861	COG0195	Participates in both transcription termination and antitermination
J171_02862	COG0779	Required for maturation of 30S ribosomal subunits
J171_02864	COG1007	ATP synthesis coupled electron transport
J171_02867	COG0713	ATP synthesis coupled electron transport
J171_02869	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J171_02870	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
J171_02872	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J171_02873	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
J171_02874	COG0649	NAD binding
J171_02875	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J171_02876	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J171_02877	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J171_02880	COG0149	triose-phosphate isomerase activity
J171_02881	COG0300	oxidoreductase activity
J171_02887	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J171_02888	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
J171_02889	COG0159	tryptophan synthase activity
J171_02891	COG0133	tryptophan synthase activity
J171_02893	COG0135	phosphoribosylanthranilate isomerase activity
J171_02894	COG0101	tRNA pseudouridine synthase activity
J171_02898	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J171_02899	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J171_02900	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J171_02901	COG2890	protein-(glutamine-N5) methyltransferase activity
J171_02903	COG0688	phosphatidylethanolamine metabolic process
J171_02905	COG0433	COG0433 Predicted ATPase
J171_02906	COG0494	nUDIX hydrolase
J171_02909	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J171_02910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J171_02915	COG0717	Belongs to the dCTP deaminase family
J171_02916	COG0489	protein tyrosine kinase activity
J171_02920	COG3590	peptidase
J171_02921	COG3590	peptidase
J171_02925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J171_02926	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J171_02927	COG2311	Membrane
J171_02928	COG1047	Peptidyl-prolyl cis-trans
J171_02929	COG0791	NLP P60 protein
J171_02930	COG0791	NLP P60 protein
J171_02932	COG4106	trans-aconitate 2-methyltransferase activity
J171_02933	COG1301	dicarboxylic acid transport
J171_02934	COG1785	Belongs to the alkaline phosphatase family
J171_02935	COG0037	tRNA processing
J171_02936	COG1722	exodeoxyribonuclease VII activity
J171_02937	COG0142	geranyltranstransferase activity
J171_02938	COG4104	PAAR repeat-containing protein
J171_02940	COG0312	modulator of DNA gyrase
J171_02941	COG3028	Belongs to the UPF0307 family
J171_02942	COG0312	modulator of DNA gyrase
J171_02944	COG3164	Protein of unknown function
J171_02945	COG1530	ribonuclease E activity
J171_02946	COG0424	maF-like protein
J171_02947	COG2968	Membrane
J171_02950	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J171_02953	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J171_02956	COG0495	leucyl-tRNA aminoacylation
J171_02958	COG3118	belongs to the thioredoxin family
J171_02963	COG2155	Conserved Protein
J171_02964	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J171_02971	COG1132	(ABC) transporter
J171_02977	COG1538	Outer membrane efflux protein
J171_02978	COG0745	RESPONSE REGULATOR receiver
J171_02979	COG5000	phosphorelay sensor kinase activity
J171_02979	COG5002	protein histidine kinase activity
J171_02980	COG0475	glutathione-regulated potassium exporter activity
J171_02981	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J171_02982	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J171_02985	COG0745	RESPONSE REGULATOR receiver
J171_02985	COG3706	GGDEF domain
J171_02986	COG1187	pseudouridine synthase activity
J171_02987	COG5002	protein histidine kinase activity
J171_02987	COG5001	Diguanylate cyclase
J171_02997	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
J171_03011	COG0667	Aldo Keto reductase
J171_03012	COG2814	Major facilitator Superfamily
J171_03013	COG0583	DNA-binding transcription factor activity
J171_03015	COG2207	Transcriptional regulator
J171_03017	COG1309	transcriptional regulator
J171_03018	COG1538	Outer membrane efflux protein
J171_03022	COG0735	belongs to the Fur family
J171_03023	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J171_03028	COG4452	Inner membrane protein CreD
J171_03030	COG2205	protein histidine kinase activity
J171_03031	COG0745	RESPONSE REGULATOR receiver
J171_03032	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
J171_03034	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J171_03041	COG0643	Histidine kinase
J171_03041	COG2198	Histidine kinase
J171_03042	COG0840	transmembrane signaling receptor activity
J171_03043	COG0835	chemotaxis
J171_03044	COG2200	EAL domain
J171_03044	COG2202	Pas domain
J171_03044	COG2199	diguanylate cyclase activity
J171_03045	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J171_03046	COG2201	protein-glutamate methylesterase activity
J171_03047	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J171_03048	COG3590	peptidase
J171_03050	COG0588	phosphoglycerate mutase activity
J171_03051	COG1515	deoxyribonuclease V activity
J171_03053	COG1741	Belongs to the pirin family
J171_03056	COG1741	Belongs to the pirin family
J171_03057	COG1966	Carbon starvation protein
J171_03058	COG2879	small protein
J171_03069	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
J171_03070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J171_03071	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J171_03072	COG2080	2 iron, 2 sulfur cluster binding
J171_03074	COG4251	negative regulation of phosphorylation
J171_03074	COG3706	GGDEF domain
J171_03074	COG2203	Gaf domain
J171_03074	COG5001	Diguanylate cyclase
J171_03083	COG0629	single-stranded DNA binding
J171_03084	COG0142	geranyltranstransferase activity
J171_03086	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J171_03089	COG0527	aspartate kinase activity
J171_03090	COG0384	phenazine biosynthesis protein PhzF
J171_03091	COG0384	phenazine biosynthesis protein PhzF
J171_03093	COG1764	response to oxidative stress
J171_03094	COG0540	Belongs to the ATCase OTCase family
J171_03095	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J171_03096	COG1678	Uncharacterized ACR, COG1678
J171_03097	COG0519	Catalyzes the synthesis of GMP from XMP
J171_03100	COG5297	Belongs to the glycosyl hydrolase family 6
J171_03103	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J171_03106	COG0739	heme binding
J171_03110	COG0693	protein deglycase activity
J171_03112	COG1959	2 iron, 2 sulfur cluster binding
J171_03113	COG0719	Fe-S assembly protein
J171_03114	COG0396	ATPase activity
J171_03115	COG0719	Fe-S assembly protein
J171_03116	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J171_03119	COG4774	siderophore transport
J171_03120	COG3128	pkhd-type hydroxylase
J171_03125	COG1477	protein flavinylation
J171_03126	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J171_03129	COG1555	photosystem II stabilization
J171_03130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J171_03132	COG3178	'Phosphotransferase
J171_03133	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J171_03135	COG0628	permease
J171_03137	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J171_03139	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J171_03143	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J171_03144	COG0271	Belongs to the BolA IbaG family
J171_03146	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
J171_03148	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
J171_03149	COG1137	ATPase activity
J171_03152	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J171_03153	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
J171_03154	COG1660	Displays ATPase and GTPase activities
J171_03156	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J171_03157	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J171_03158	COG2239	Acts as a magnesium transporter
J171_03160	COG1294	oxidase, subunit
J171_03161	COG1271	oxidase subunit
J171_03163	COG1113	amino acid transport
J171_03166	COG2197	response regulator
J171_03167	COG0531	amino acid
J171_03172	COG1234	tRNA 3'-trailer cleavage
J171_03179	COG2814	Major facilitator Superfamily
J171_03181	COG0754	glutathionylspermidine amidase activity
J171_03186	COG1842	Phage shock protein A
J171_03188	COG0259	pyridoxamine-phosphate oxidase activity
J171_03189	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J171_03190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J171_03192	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J171_03206	COG2814	Major facilitator Superfamily
J171_03210	COG0784	Response regulator, receiver
J171_03210	COG2198	Histidine kinase
J171_03210	COG2205	protein histidine kinase activity
J171_03211	COG2353	YceI-like domain
J171_03215	COG1760	l-serine dehydratase
J171_03217	COG0527	aspartate kinase activity
J171_03217	COG0460	homoserine dehydrogenase
J171_03218	COG0626	cystathionine gamma-synthase activity
J171_03219	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J171_03221	COG0739	heme binding
J171_03222	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J171_03223	COG1272	protein, Hemolysin III
J171_03224	COG2982	Protein involved in outer membrane biogenesis
J171_03225	COG0516	GMP reductase activity
J171_03225	COG0517	IMP dehydrogenase activity
J171_03226	COG0463	Glycosyl transferase, family 2
J171_03227	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J171_03228	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
J171_03230	COG4771	TonB-dependent receptor
J171_03232	COG1309	transcriptional regulator
J171_03233	COG2267	carboxylic ester hydrolase activity
J171_03234	COG1960	acyl-CoA dehydrogenase activity
J171_03239	COG0509	glycine decarboxylation via glycine cleavage system
J171_03240	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J171_03242	COG0330	HflC and HflK could
J171_03243	COG1742	UPF0060 membrane protein
J171_03244	COG3956	TIGRFAM MazG family protein
J171_03246	COG0494	nUDIX hydrolase
J171_03248	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J171_03249	COG0837	glucose binding
J171_03252	COG3858	chitin binding
J171_03252	COG1388	LysM domain
J171_03253	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J171_03255	COG1472	Belongs to the glycosyl hydrolase 3 family
J171_03258	COG0531	amino acid
J171_03260	COG1486	melibiose metabolic process
J171_03262	COG3537	Alpha-1,2-mannosidase
J171_03269	COG3142	Participates in the control of copper homeostasis
J171_03270	COG1446	asparaginase
J171_03275	COG0840	transmembrane signaling receptor activity
J171_03279	COG0189	ligase activity
J171_03281	COG1397	ADP-ribosylglycohydrolase
J171_03283	COG1199	ATP-dependent helicase activity
J171_03285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J171_03286	COG1215	transferase activity, transferring glycosyl groups
J171_03288	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J171_03289	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
J171_03290	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
J171_03291	COG0535	radical SAM domain protein
J171_03292	COG0535	radical SAM domain protein
J171_03295	COG0837	glucose binding
J171_03297	COG1643	Atp-dependent helicase
J171_03298	COG0783	Belongs to the Dps family
J171_03299	COG0514	ATP-dependent DNA helicase (RecQ)
J171_03306	COG0840	transmembrane signaling receptor activity
J171_03310	COG3920	Histidine kinase
J171_03311	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
J171_03313	COG0602	queuosine metabolic process
J171_03315	COG2885	chlorophyll binding
J171_03316	COG0823	Involved in the tonB-independent uptake of proteins
J171_03318	COG0848	biopolymer transport protein
J171_03320	COG0824	Thioesterase
J171_03321	COG2255	four-way junction helicase activity
J171_03323	COG3158	transport of potassium into the cell
J171_03324	COG0632	four-way junction helicase activity
J171_03325	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J171_03326	COG0217	transcriptional regulatory protein
J171_03329	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J171_03332	COG0477	Major facilitator Superfamily
J171_03340	COG0488	(ABC) transporter
J171_03346	COG4651	solute:proton antiporter activity
J171_03346	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J171_03351	COG4772	TonB-dependent receptor
J171_03353	COG4264	IucA IucC family
J171_03356	COG0019	diaminopimelate decarboxylase activity
J171_03361	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
J171_03363	COG1492	cobalamin metabolic process
J171_03366	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
J171_03370	COG4206	TonB-dependent receptor
J171_03372	COG0542	response to heat
J171_03373	COG1116	anion transmembrane transporter activity
J171_03374	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J171_03375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J171_03376	COG0667	Aldo Keto reductase
J171_03378	COG4771	TonB-dependent receptor
J171_03379	COG2827	Endonuclease containing a URI domain
J171_03387	COG1877	trehalose-phosphatase activity
J171_03388	COG3387	PFAM Glycoside hydrolase 15-related
J171_03391	COG0840	transmembrane signaling receptor activity
J171_03392	COG3011	Protein conserved in bacteria
J171_03395	COG0564	pseudouridine synthase activity
J171_03396	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J171_03398	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J171_03398	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
J171_03400	COG2963	transposase activity
J171_03404	COG2951	lytic endotransglycosylase activity
J171_03405	COG4644	lycopene metabolic process
J171_03409	COG2369	cell adhesion
J171_03414	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
J171_03415	COG0045	succinate-CoA ligase (ADP-forming) activity
J171_03419	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J171_03425	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
J171_03426	COG0237	dephospho-CoA kinase activity
J171_03429	COG2963	transposase activity
J171_03431	COG5002	protein histidine kinase activity
J171_03432	COG0745	RESPONSE REGULATOR receiver
J171_03434	COG0189	ligase activity
J171_03448	COG2003	Belongs to the UPF0758 family
J171_03453	COG0784	Response regulator, receiver
J171_03453	COG4191	Histidine kinase
J171_03454	COG0784	Response regulator, receiver
J171_03454	COG4191	Histidine kinase
J171_03473	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J171_03479	COG2022	thiamine diphosphate biosynthetic process
J171_03480	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J171_03481	COG0471	metal ion transport
J171_03481	COG3273	potassium ion transport
J171_03485	COG1970	mechanosensitive ion channel activity
J171_03489	COG3250	beta-galactosidase activity
J171_03490	COG4948	Mandelate Racemase Muconate Lactonizing
J171_03493	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J171_03495	COG0308	aminopeptidase N
J171_03498	COG2963	transposase activity
J171_03504	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J171_03506	COG2895	sulfate adenylyltransferase (ATP) activity
J171_03506	COG0529	Catalyzes the synthesis of activated sulfate
J171_03507	COG0175	sulfate reduction
J171_03508	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J171_03509	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J171_03510	COG0175	sulfate reduction
J171_03517	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J171_03517	COG1648	precorrin-2 dehydrogenase activity
J171_03520	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
J171_03521	COG3588	fructose-bisphosphate aldolase
J171_03522	COG0469	pyruvate kinase activity
J171_03524	COG0126	phosphoglycerate kinase activity
J171_03529	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J171_03531	COG3047	cAMP biosynthetic process
J171_03532	COG3047	cAMP biosynthetic process
J171_03534	COG3453	Protein conserved in bacteria
J171_03534	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J171_03535	COG0725	ABC transporter, periplasmic molybdate-binding protein
J171_03536	COG4149	molybdate abc transporter
J171_03537	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
J171_03544	COG1376	ErfK ybiS ycfS ynhG family protein
J171_03545	COG0739	heme binding
J171_03547	COG4773	Receptor
J171_03548	COG0596	Alpha beta hydrolase
J171_03549	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
J171_03550	COG1301	dicarboxylic acid transport
J171_03552	COG2304	oxidoreductase activity
J171_03556	COG0714	Associated with various cellular activities
J171_03563	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J171_03567	COG0254	rRNA binding
J171_03569	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J171_03571	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J171_03572	COG1758	RNA polymerase activity
J171_03573	COG0194	GDP metabolic process
J171_03574	COG1561	YicC-like family, N-terminal region
J171_03575	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J171_03577	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J171_03578	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J171_03581	COG0006	proline dipeptidase activity
J171_03583	COG0006	proline dipeptidase activity
J171_03584	COG3079	Belongs to the UPF0149 family
J171_03588	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J171_03590	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
J171_03592	COG2912	Transglutaminase-like superfamily
J171_03593	COG1773	rubredoxin
J171_03594	COG0352	thiamine-phosphate diphosphorylase activity
J171_03597	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J171_03600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J171_03606	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J171_03607	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J171_03608	COG1028	Short-chain dehydrogenase reductase Sdr
J171_03610	COG0671	phosphoesterase, PA-phosphatase related
J171_03611	COG3781	membrane
J171_03613	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J171_03614	COG0563	adenylate kinase activity
J171_03617	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
J171_03619	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
J171_03623	COG3710	Transcriptional regulator
J171_03624	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
J171_03627	COG0840	transmembrane signaling receptor activity
J171_03628	COG0405	Gamma-glutamyltransferase
J171_03629	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J171_03633	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J171_03634	COG0473	3-isopropylmalate dehydrogenase activity
J171_03635	COG0066	3-isopropylmalate dehydratase activity
J171_03636	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J171_03640	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J171_03641	COG1538	Outer membrane efflux protein
J171_03642	COG1519	Transferase
J171_03643	COG1560	Kdo2-lipid A biosynthetic process
J171_03648	COG0280	phosphate acetyltransferase
J171_03648	COG0281	malic enzyme
J171_03649	COG1301	dicarboxylic acid transport
J171_03654	COG0583	DNA-binding transcription factor activity
J171_03655	COG0667	Aldo Keto reductase
J171_03659	COG2197	response regulator
J171_03660	COG1840	ABC-type Fe3 transport system, periplasmic component
J171_03661	COG0642	Histidine kinase
J171_03664	COG2851	Citrate transporter
J171_03666	COG1028	Short-chain dehydrogenase reductase Sdr
J171_03667	COG1609	Transcriptional regulator
J171_03668	COG2211	Major facilitator Superfamily
J171_03673	COG1162	GTPase activity
J171_03677	COG4773	Receptor
J171_03678	COG0726	polysaccharide deacetylase
J171_03679	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J171_03682	COG2963	transposase activity
J171_03683	COG2801	Transposase and inactivated derivatives
J171_03687	COG1307	EDD domain protein, DegV family
J171_03688	COG0242	peptide deformylase activity
J171_03692	COG0457	Tetratricopeptide repeat
J171_03693	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
J171_03694	COG1215	transferase activity, transferring glycosyl groups
J171_03695	COG1215	transferase activity, transferring glycosyl groups
J171_03699	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
J171_03709	COG2188	Transcriptional regulator
J171_03711	COG1450	Type ii and iii secretion system protein
J171_03714	COG3166	PFAM Fimbrial assembly family protein
J171_03715	COG3156	type II secretion system protein K
J171_03716	COG4795	General secretion pathway protein
J171_03717	COG2165	general secretion pathway protein
J171_03718	COG4970	Tfp pilus assembly protein FimT
J171_03719	COG2165	general secretion pathway protein
J171_03720	COG1459	type II secretion system
J171_03721	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J171_03722	COG1404	Belongs to the peptidase S8 family
J171_03723	COG5295	Hep Hag repeat protein
J171_03724	COG1404	Belongs to the peptidase S8 family
J171_03725	COG5295	Hep Hag repeat protein
J171_03726	COG0047	phosphoribosylformylglycinamidine synthase activity
J171_03726	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J171_03727	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J171_03728	COG4974	Belongs to the 'phage' integrase family
J171_03731	COG0795	lipopolysaccharide-transporting ATPase activity
J171_03733	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J171_03736	COG0525	valine-tRNA ligase activity
J171_03742	COG1183	phosphatidylcholine synthase activity
J171_03744	COG0442	prolyl-tRNA aminoacylation
J171_03747	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J171_03748	COG1127	ABC transporter
J171_03749	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J171_03749	COG3218	ABC-type transport auxiliary lipoprotein component
J171_03756	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J171_03757	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
J171_03757	COG0662	Cupin 2, conserved barrel domain protein
J171_03763	COG2086	electron transfer activity
J171_03766	COG0546	phosphoglycolate phosphatase activity
J171_03766	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J171_03767	COG0277	FAD linked oxidase domain protein
J171_03770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J171_03776	COG0438	transferase activity, transferring glycosyl groups
J171_03776	COG1216	Glycosyl transferase, family 2
J171_03780	COG0626	cystathionine gamma-synthase activity
J171_03786	COG0625	glutathione transferase activity
J171_03788	COG0513	Belongs to the DEAD box helicase family
J171_03791	COG4206	TonB-dependent receptor
J171_03792	COG0720	synthase
J171_03794	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
J171_03795	COG1956	GAF domain-containing protein
J171_03797	COG2819	hydrolase of the alpha beta superfamily
J171_03800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J171_03801	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J171_03804	COG0339	signal peptide processing
J171_03807	COG2132	Multicopper oxidase
J171_03815	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J171_03816	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J171_03817	COG4591	ABC-type transport system involved in lipoprotein release permease component
J171_03817	COG1136	(ABC) transporter
J171_03818	COG0577	efflux transmembrane transporter activity
J171_03818	COG1136	(ABC) transporter
J171_03819	COG0577	efflux transmembrane transporter activity
J171_03821	COG2204	response regulator
J171_03822	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J171_03825	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J171_03826	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J171_03827	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J171_03828	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J171_03829	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J171_03830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J171_03832	COG0356	it plays a direct role in the translocation of protons across the membrane
J171_03836	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J171_03838	COG0508	dehydrogenase complex catalyzes the overall conversion of
J171_03845	COG2011	ABC-type metal ion transport system permease component
J171_03846	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J171_03847	COG0697	spore germination
J171_03848	COG1666	GTP binding
J171_03850	COG2198	Histidine kinase
J171_03850	COG5002	protein histidine kinase activity
J171_03850	COG0784	Response regulator, receiver
J171_03854	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J171_03855	COG1187	pseudouridine synthase activity
J171_03856	COG2813	Specifically methylates the guanine in position
J171_03860	COG2205	protein histidine kinase activity
J171_03860	COG2202	Pas domain
J171_03864	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J171_03865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J171_03866	COG1522	sequence-specific DNA binding
J171_03876	COG0842	Transport permease protein
J171_03877	COG1131	(ABC) transporter
J171_03878	COG0025	NhaP-type Na H and K H
J171_03879	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
J171_03880	COG1573	uracil-dna glycosylase
J171_03882	COG3384	dioxygenase
J171_03884	COG0583	DNA-binding transcription factor activity
J171_03886	COG0667	Aldo Keto reductase
J171_03888	COG3590	peptidase
J171_03892	COG0531	amino acid
J171_03895	COG2972	Histidine kinase
J171_03898	COG3685	Protein conserved in bacteria
J171_03899	COG3546	catalase activity
J171_03907	COG1271	oxidase subunit
J171_03908	COG1294	oxidase, subunit
J171_03911	COG1028	Short-chain dehydrogenase reductase Sdr
J171_03912	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J171_03916	COG1132	(ABC) transporter
J171_03919	COG1063	alcohol dehydrogenase
J171_03934	COG0251	oxidation-reduction process
J171_03940	COG0840	transmembrane signaling receptor activity
J171_03944	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J171_03953	COG0024	Methionine aminopeptidase
J171_03958	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J171_03959	COG1490	D-aminoacyl-tRNA deacylase activity
J171_03960	COG1560	Kdo2-lipid A biosynthetic process
J171_03969	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J171_03969	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J171_03970	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J171_03971	COG0242	peptide deformylase activity
J171_03972	COG1652	LysM domain
J171_03973	COG0758	DNA mediated transformation
J171_03974	COG2922	Belongs to the Smg family
J171_03977	COG1754	DNA topoisomerase type I activity
J171_03977	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J171_03978	COG0009	L-threonylcarbamoyladenylate synthase
J171_03981	COG1028	Short-chain dehydrogenase reductase Sdr
J171_03983	COG0616	signal peptide processing
J171_03984	COG0534	Mate efflux family protein
J171_03988	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J171_03989	COG0625	glutathione transferase activity
J171_03992	COG1252	NADH dehydrogenase
J171_03993	COG2860	membrane
J171_03994	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J171_03995	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J171_03996	COG2201	protein-glutamate methylesterase activity
J171_03997	COG2177	Part of the ABC transporter FtsEX involved in
J171_03998	COG2884	Cell division ATP-binding protein ftsE
J171_03999	COG0513	Belongs to the DEAD box helicase family
J171_04000	COG3118	belongs to the thioredoxin family
J171_04001	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J171_04002	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
J171_04003	COG0583	DNA-binding transcription factor activity
J171_04013	COG1518	maintenance of DNA repeat elements
J171_04014	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
J171_04016	COG1652	LysM domain
J171_04017	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J171_04017	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J171_04018	COG1473	amidohydrolase
J171_04019	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J171_04020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J171_04022	COG5383	Protein conserved in bacteria
J171_04030	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
J171_04031	COG3023	N-Acetylmuramoyl-L-alanine amidase
J171_04033	COG4948	Mandelate Racemase Muconate Lactonizing
J171_04035	COG0531	amino acid
J171_04038	COG4682	membrane
J171_04039	COG2133	pyrroloquinoline quinone binding
J171_04041	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J171_04042	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J171_04043	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J171_04044	COG1610	YqeY-like protein
J171_04045	COG1295	ribonuclease BN
J171_04046	COG0358	DNA primase activity
J171_04049	COG0109	protoheme IX farnesyltransferase activity
J171_04055	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
J171_04058	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J171_04068	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J171_04069	COG0739	heme binding
J171_04070	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
J171_04072	COG2223	nitrite transmembrane transporter activity
J171_04073	COG0708	Exodeoxyribonuclease III
J171_04074	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J171_04076	COG1192	Involved in chromosome partitioning
J171_04077	COG1475	DNA binding
J171_04080	COG0463	Glycosyl transferase, family 2
J171_04084	COG0756	dUTP diphosphatase activity
J171_04085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J171_04086	COG2003	Belongs to the UPF0758 family
J171_04087	COG0018	arginyl-trna synthetase
J171_04090	COG4221	oxidoreductase activity
J171_04091	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J171_04091	COG2755	lipolytic protein G-D-S-L family
J171_04093	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J171_04094	COG1166	arginine decarboxylase activity
J171_04095	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
J171_04102	COG0606	chelatase, subunit chli
J171_04116	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J171_04125	COG0606	chelatase, subunit chli
J171_04128	COG4943	cyclic-guanylate-specific phosphodiesterase activity
J171_04137	COG1690	Belongs to the RtcB family
J171_04145	COG1090	epimerase
J171_04146	COG0745	RESPONSE REGULATOR receiver
J171_04147	COG0642	Histidine kinase
J171_04151	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J171_04156	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J171_04157	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J171_04160	COG0753	catalase activity
J171_04163	COG2197	response regulator
J171_04164	COG4585	Histidine kinase
J171_04165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J171_04166	COG1136	(ABC) transporter
J171_04170	COG2962	Rard protein
J171_04172	COG0697	spore germination
J171_04175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J171_04176	COG0180	Tryptophanyl-tRNA synthetase
J171_04177	COG3237	CsbD-like
J171_04185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J171_04188	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
J171_04189	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J171_04189	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J171_04194	COG2205	protein histidine kinase activity
J171_04195	COG0745	RESPONSE REGULATOR receiver
J171_04197	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J171_04201	COG1199	ATP-dependent helicase activity
J171_04204	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J171_04215	COG0625	glutathione transferase activity
J171_04222	COG4555	ABC transporter
J171_04224	COG1476	TRANSCRIPTIONal
J171_04233	COG0633	Ferredoxin
J171_04233	COG0543	2 iron, 2 sulfur cluster binding
J171_04234	COG1131	(ABC) transporter
J171_04235	COG0842	Transport permease protein
J171_04238	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
J171_04244	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J171_04245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J171_04247	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J171_04247	COG0045	succinate-CoA ligase (ADP-forming) activity
J171_04247	COG1042	CoA-binding domain protein
J171_04248	COG2239	Acts as a magnesium transporter
J171_04249	COG3338	carbonate dehydratase activity
J171_04251	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J171_04252	COG3387	PFAM Glycoside hydrolase 15-related
J171_04255	COG3100	YcgL domain-containing protein
J171_04256	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J171_04258	COG0463	Glycosyl transferase, family 2
J171_04261	COG1028	Short-chain dehydrogenase reductase Sdr
J171_04269	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J171_04272	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J171_04277	COG4946	Tricorn protease homolog
J171_04277	COG1506	peptidase
J171_04277	COG0823	Involved in the tonB-independent uptake of proteins
J171_04280	COG0408	coproporphyrinogen oxidase activity
J171_04287	COG0515	serine threonine protein kinase
J171_04287	COG2815	serine threonine protein kinase
J171_04288	COG0631	protein serine/threonine phosphatase activity
J171_04295	COG3501	Rhs element vgr protein
J171_04321	COG0210	DNA helicase
J171_04323	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J171_04324	COG0583	DNA-binding transcription factor activity
J171_04325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J171_04327	COG2159	amidohydrolase
J171_04328	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J171_04329	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J171_04331	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J171_04335	COG0357	Ribosomal RNA small subunit methyltransferase G
J171_04336	COG3540	Alkaline phosphatase
J171_04339	COG2091	lysine biosynthetic process via aminoadipic acid
J171_04342	COG0708	Exodeoxyribonuclease III
J171_04344	COG1940	carbohydrate kinase activity
J171_04344	COG1846	Transcriptional regulator
J171_04346	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J171_04348	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J171_04349	COG3162	membrane
J171_04351	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J171_04357	COG3507	Belongs to the glycosyl hydrolase 43 family
J171_04360	COG1028	Short-chain dehydrogenase reductase Sdr
J171_04361	COG0179	Fumarylacetoacetate (FAA) hydrolase
J171_04362	COG4948	Mandelate Racemase Muconate Lactonizing
J171_04364	COG3254	rhamnose metabolic process
J171_04365	COG0738	Major facilitator superfamily
J171_04366	COG1414	Transcriptional regulator
J171_04367	COG1971	Probably functions as a manganese efflux pump
J171_04368	COG2205	protein histidine kinase activity
J171_04370	COG3459	Glycosyltransferase 36 associated
J171_04371	COG2211	Major facilitator Superfamily
J171_04372	COG3265	gluconokinase activity
J171_04373	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J171_04377	COG2911	Protein conserved in bacteria
J171_04378	COG0729	surface antigen
J171_04381	COG2963	transposase activity
J171_04386	COG0752	glycyl-tRNA synthetase alpha subunit
J171_04387	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J171_04389	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J171_04389	COG0519	Catalyzes the synthesis of GMP from XMP
J171_04391	COG0805	protein transport
J171_04392	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J171_04393	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J171_04395	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J171_04398	COG2974	May be involved in recombination
J171_04399	COG0037	tRNA processing
J171_04400	COG2115	Belongs to the xylose isomerase family
J171_04402	COG3661	Belongs to the glycosyl hydrolase 67 family
J171_04404	COG4948	Mandelate Racemase Muconate Lactonizing
J171_04406	COG1472	Belongs to the glycosyl hydrolase 3 family
J171_04407	COG0246	Mannitol dehydrogenase
J171_04415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J171_04416	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J171_04421	COG3386	PFAM SMP-30 Gluconolaconase
J171_04423	COG3250	beta-galactosidase activity
J171_04424	COG1904	glucuronate isomerase
J171_04425	COG3693	PFAM glycoside hydrolase, family 10
J171_04427	COG3693	PFAM glycoside hydrolase, family 10
J171_04430	COG2211	Major facilitator Superfamily
J171_04442	COG2937	Belongs to the GPAT DAPAT family
J171_04448	COG0284	orotidine-5'-phosphate decarboxylase activity
J171_04449	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
J171_04451	COG3132	Protein of unknown function, DUF480
J171_04454	COG0210	DNA helicase
J171_04455	COG1435	thymidine kinase activity
J171_04457	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
J171_04459	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J171_04466	COG3135	benzoate transporter
J171_04470	COG0676	glucose-6-phosphate 1-epimerase activity
J171_04472	COG3012	SEC-C Motif Domain Protein
J171_04473	COG0730	response to heat
J171_04477	COG0302	gtp cyclohydrolase
J171_04480	COG1566	PFAM secretion protein HlyD family protein
J171_04482	COG1289	transmembrane transporter activity
J171_04483	COG0477	Major facilitator Superfamily
J171_04485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J171_04489	COG4691	Plasmid stability protein
J171_04490	COG1487	ribonuclease activity
J171_04495	COG0564	pseudouridine synthase activity
J171_04497	COG2963	transposase activity
J171_04501	COG0439	Biotin carboxylase
J171_04512	COG1074	ATP-dependent DNA helicase activity
J171_04513	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
J171_04515	COG1127	ABC transporter
J171_04516	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J171_04517	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J171_04520	COG2853	Lipoprotein
J171_04522	COG0386	Belongs to the glutathione peroxidase family
J171_04524	COG1322	Protein conserved in bacteria
J171_04525	COG0604	alcohol dehydrogenase
J171_04526	COG0583	DNA-binding transcription factor activity
J171_04528	COG0625	glutathione transferase activity
J171_04530	COG0531	amino acid
J171_04531	COG3537	Alpha-1,2-mannosidase
J171_04533	COG3706	GGDEF domain
J171_04534	COG3835	regulator
J171_04535	COG1929	Belongs to the glycerate kinase type-1 family
J171_04536	COG2271	Major facilitator Superfamily
J171_04539	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J171_04541	COG0861	Integral membrane protein TerC family
J171_04543	COG0584	glycerophosphoryl diester phosphodiesterase
J171_04546	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
J171_04547	COG0726	polysaccharide deacetylase
J171_04548	COG0706	membrane insertase activity
J171_04549	COG0594	ribonuclease P activity
J171_04550	COG0230	Belongs to the bacterial ribosomal protein bL34 family