locus-tag	class	description
BI315_00015	COG3279	Response regulator of the LytR AlgR family
BI315_00020	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BI315_00025	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BI315_00035	COG2198	Histidine kinase
BI315_00035	COG2205	protein histidine kinase activity
BI315_00035	COG0784	Response regulator, receiver
BI315_00040	COG1024	Enoyl-CoA hydratase
BI315_00045	COG0318	PFAM AMP-dependent synthetase and ligase
BI315_00075	COG2267	carboxylic ester hydrolase activity
BI315_00085	COG2201	protein-glutamate methylesterase activity
BI315_00090	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BI315_00100	COG0840	transmembrane signaling receptor activity
BI315_00110	COG0835	chemotaxis
BI315_00125	COG0840	transmembrane signaling receptor activity
BI315_00130	COG0840	transmembrane signaling receptor activity
BI315_00135	COG0840	transmembrane signaling receptor activity
BI315_00140	COG0840	transmembrane signaling receptor activity
BI315_00145	COG0840	transmembrane signaling receptor activity
BI315_00155	COG0840	transmembrane signaling receptor activity
BI315_00160	COG0840	transmembrane signaling receptor activity
BI315_00165	COG0840	transmembrane signaling receptor activity
BI315_00170	COG0840	transmembrane signaling receptor activity
BI315_00185	COG0840	transmembrane signaling receptor activity
BI315_00190	COG0840	transmembrane signaling receptor activity
BI315_00200	COG0840	transmembrane signaling receptor activity
BI315_00205	COG0643	Histidine kinase
BI315_00205	COG2198	Histidine kinase
BI315_00210	COG0745	RESPONSE REGULATOR receiver
BI315_00225	COG1192	Involved in chromosome partitioning
BI315_00230	COG1360	Flagellar Motor Protein
BI315_00235	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BI315_00310	COG3002	Belongs to the UPF0753 family
BI315_00350	COG0641	radical SAM
BI315_00370	COG2198	Histidine kinase
BI315_00370	COG0643	Histidine kinase
BI315_00390	COG0455	bacterial-type flagellum organization
BI315_00400	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BI315_00415	COG5001	Diguanylate cyclase
BI315_00415	COG3300	MHYT domain
BI315_00425	COG5001	Diguanylate cyclase
BI315_00425	COG3300	MHYT domain
BI315_00430	COG1684	flagellar biosynthetic protein fliR
BI315_00435	COG1987	bacterial-type flagellum assembly
BI315_00450	COG3190	flagellar
BI315_00500	COG1677	Flagellar hook-basal body complex protein FliE
BI315_00530	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_00535	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_00540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI315_00555	COG2204	response regulator
BI315_00560	COG2201	protein-glutamate methylesterase activity
BI315_00590	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BI315_00595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BI315_00600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BI315_00610	COG1705	Flagellar rod assembly protein muramidase FlgJ
BI315_00610	COG3951	Flagellar rod assembly protein muramidase FlgJ
BI315_00615	COG1706	bacterial-type flagellum-dependent cell motility
BI315_00620	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BI315_00625	COG4786	Flagellar basal body rod
BI315_00635	COG4787	bacterial-type flagellum-dependent cell motility
BI315_00640	COG1749	Flagellar hook protein flgE
BI315_00645	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BI315_00650	COG1558	bacterial-type flagellum-dependent cell motility
BI315_00660	COG0784	Response regulator, receiver
BI315_00660	COG0835	chemotaxis
BI315_00685	COG5002	protein histidine kinase activity
BI315_00715	COG2915	High frequency lysogenization protein hflD homolog
BI315_00720	COG0482	sulfurtransferase activity
BI315_00730	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BI315_00735	COG0542	response to heat
BI315_00740	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BI315_00745	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BI315_00755	COG0492	ferredoxin-NADP+ reductase activity
BI315_00760	COG1674	ftsk spoiiie
BI315_00770	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BI315_00780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BI315_00785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BI315_00795	COG0183	Belongs to the thiolase family
BI315_00800	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI315_00800	COG1024	Enoyl-CoA hydratase
BI315_00810	COG0105	UTP biosynthetic process
BI315_00815	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BI315_00825	COG1426	Protein conserved in bacteria
BI315_00835	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI315_00840	COG1160	GTP binding
BI315_00845	COG0303	'Molybdopterin
BI315_00850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BI315_00890	COG0708	Exodeoxyribonuclease III
BI315_00900	COG0303	'Molybdopterin
BI315_00905	COG0746	molybdenum cofactor guanylyltransferase activity
BI315_00920	COG1914	H( )-stimulated, divalent metal cation uptake system
BI315_00925	COG1321	iron dependent repressor
BI315_00930	COG0590	tRNA wobble adenosine to inosine editing
BI315_00935	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BI315_00940	COG0668	transmembrane transport
BI315_00950	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BI315_00965	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_00970	COG1183	phosphatidylcholine synthase activity
BI315_00980	COG3243	poly(R)-hydroxyalkanoic acid synthase
BI315_00995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI315_00995	COG0723	plastoquinol--plastocyanin reductase activity
BI315_01005	COG2183	response to ionizing radiation
BI315_01010	COG2205	protein histidine kinase activity
BI315_01010	COG0784	Response regulator, receiver
BI315_01090	COG0800	Aldolase
BI315_01095	COG0129	dihydroxy-acid dehydratase activity
BI315_01100	COG0363	glucosamine-6-phosphate deaminase activity
BI315_01105	COG0837	glucose binding
BI315_01110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BI315_01135	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BI315_01150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BI315_01155	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BI315_01165	COG4591	ABC-type transport system involved in lipoprotein release permease component
BI315_01170	COG1136	(ABC) transporter
BI315_01185	COG0811	peptide transport
BI315_01195	COG1132	(ABC) transporter
BI315_01200	COG1663	tetraacyldisaccharide 4'-kinase activity
BI315_01205	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BI315_01210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BI315_01220	COG0322	excinuclease ABC activity
BI315_01225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BI315_01250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BI315_01275	COG2801	Transposase and inactivated derivatives
BI315_01285	COG0582	viral genome integration into host DNA
BI315_01295	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BI315_01325	COG1530	ribonuclease E activity
BI315_01335	COG3064	Membrane
BI315_01340	COG0428	transporter
BI315_01350	COG2154	pterin-4-alpha-carbinolamine dehydratase
BI315_01355	COG0316	Belongs to the HesB IscA family
BI315_01355	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BI315_01400	COG2226	methyltransferase
BI315_01400	COG1073	alpha beta
BI315_01410	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_01485	COG1238	metal cluster binding
BI315_01520	COG3279	Response regulator of the LytR AlgR family
BI315_01570	COG4566	intracellular signal transduction
BI315_01580	COG5001	Diguanylate cyclase
BI315_01600	COG3685	Protein conserved in bacteria
BI315_01625	COG1648	precorrin-2 dehydrogenase activity
BI315_01625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BI315_01640	COG2814	Major facilitator Superfamily
BI315_01655	COG1335	isochorismatase
BI315_01670	COG2197	response regulator
BI315_01685	COG0583	DNA-binding transcription factor activity
BI315_01690	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BI315_01695	COG3002	Belongs to the UPF0753 family
BI315_01710	COG1396	sequence-specific DNA binding
BI315_01715	COG5489	Protein of unknown function (DUF736)
BI315_01720	COG2003	Belongs to the UPF0758 family
BI315_01745	COG0582	viral genome integration into host DNA
BI315_01760	COG4774	siderophore transport
BI315_01780	COG2336	PFAM SpoVT AbrB
BI315_01805	COG4206	TonB-dependent receptor
BI315_01845	COG2274	protein secretion by the type I secretion system
BI315_01855	COG1192	Involved in chromosome partitioning
BI315_01900	COG0270	DNA (cytosine-5-)-methyltransferase activity
BI315_01950	COG4804	nuclease activity
BI315_01965	COG5006	permease, DMT superfamily
BI315_01980	COG2249	NAD(P)H dehydrogenase (quinone) activity
BI315_01990	COG3938	Belongs to the proline racemase family
BI315_01995	COG0655	NAD(P)H dehydrogenase (quinone) activity
BI315_02005	COG2807	transmembrane transport
BI315_02010	COG2207	Transcriptional regulator
BI315_02160	COG0210	DNA helicase
BI315_02240	COG2084	Dehydrogenase
BI315_02260	COG2003	Belongs to the UPF0758 family
BI315_02295	COG0582	viral genome integration into host DNA
BI315_02300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BI315_02300	COG0519	Catalyzes the synthesis of GMP from XMP
BI315_02310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BI315_02320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BI315_02320	COG0475	glutathione-regulated potassium exporter activity
BI315_02325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BI315_02335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BI315_02340	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BI315_02350	COG0776	regulation of translation
BI315_02355	COG0539	negative regulation of cytoplasmic translation
BI315_02360	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BI315_02365	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BI315_02380	COG2957	Belongs to the agmatine deiminase family
BI315_02385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BI315_02410	COG0395	ABC-type sugar transport system, permease component
BI315_02415	COG1175	transmembrane transport
BI315_02445	COG2350	Protein conserved in bacteria
BI315_02450	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BI315_02455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BI315_02460	COG1187	pseudouridine synthase activity
BI315_02480	COG0436	Aminotransferase
BI315_02485	COG4133	protoheme IX ABC transporter activity
BI315_02505	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BI315_02510	COG1138	Cytochrome C-type biogenesis protein
BI315_02530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI315_02535	COG1278	Cold shock
BI315_02540	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BI315_02545	COG4988	ABC transporter
BI315_02555	COG1294	oxidase, subunit
BI315_02585	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BI315_02600	COG0165	Argininosuccinate lyase
BI315_02605	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BI315_02615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BI315_02630	COG0137	argininosuccinate synthase activity
BI315_02635	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BI315_02645	COG0215	cysteine-tRNA ligase activity
BI315_02650	COG2166	iron-sulfur cluster assembly
BI315_02660	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BI315_02665	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BI315_02670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BI315_02700	COG4302	ethanolamine ammonia-lyase activity
BI315_02735	COG2963	transposase activity
BI315_02765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BI315_02770	COG0402	S-adenosylhomocysteine deaminase activity
BI315_02780	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BI315_02785	COG1509	lysine 2,3-aminomutase activity
BI315_02790	COG5001	Diguanylate cyclase
BI315_02790	COG3300	MHYT domain
BI315_02805	COG0483	inositol monophosphate 1-phosphatase activity
BI315_02835	COG0513	Belongs to the DEAD box helicase family
BI315_02840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BI315_02845	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BI315_02855	COG0625	glutathione transferase activity
BI315_02865	COG4681	YaeQ
BI315_02870	COG2081	HI0933 family
BI315_02880	COG0501	Belongs to the peptidase M48B family
BI315_02885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI315_02890	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_02915	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BI315_02920	COG0860	N-Acetylmuramoyl-L-alanine amidase
BI315_02925	COG0802	atpase or kinase
BI315_02930	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BI315_02930	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BI315_02935	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BI315_02940	COG1570	exodeoxyribonuclease VII activity
BI315_02950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BI315_03135	COG0835	chemotaxis
BI315_03140	COG0840	transmembrane signaling receptor activity
BI315_03145	COG2094	Belongs to the DNA glycosylase MPG family
BI315_03150	COG1201	RNA secondary structure unwinding
BI315_03170	COG2969	positive regulation of protein catabolic process
BI315_03175	COG0625	glutathione transferase activity
BI315_03180	COG2857	Cytochrome c1
BI315_03185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BI315_03190	COG0723	plastoquinol--plastocyanin reductase activity
BI315_03200	COG0741	lytic transglycosylase activity
BI315_03215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BI315_03220	COG1702	phosphate starvation-inducible protein PhoH
BI315_03230	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BI315_03240	COG4535	Mg2 and Co2 transporter CorC
BI315_03255	COG1012	belongs to the aldehyde dehydrogenase family
BI315_03260	COG1177	transmembrane transport
BI315_03265	COG1176	ABC-type spermidine putrescine transport system, permease component I
BI315_03270	COG3842	ATPase activity
BI315_03290	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BI315_03305	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BI315_03310	COG0174	glutamine synthetase
BI315_03315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI315_03320	COG3706	GGDEF domain
BI315_03320	COG0745	RESPONSE REGULATOR receiver
BI315_03325	COG2703	oxygen carrier activity
BI315_03330	COG0477	Major facilitator Superfamily
BI315_03340	COG0243	molybdopterin cofactor binding
BI315_03345	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BI315_03375	COG2733	membrane
BI315_03380	COG5002	protein histidine kinase activity
BI315_03380	COG0784	Response regulator, receiver
BI315_03380	COG2205	protein histidine kinase activity
BI315_03390	COG0477	Major facilitator Superfamily
BI315_03400	COG2902	Dehydrogenase
BI315_03410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI315_03415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI315_03420	COG1609	Transcriptional regulator
BI315_03425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BI315_03425	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI315_03430	COG1105	Belongs to the carbohydrate kinase PfkB family
BI315_03435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI315_03435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI315_03480	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BI315_03490	COG1862	Preprotein translocase
BI315_03495	COG0343	queuine tRNA-ribosyltransferase activity
BI315_03500	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BI315_03535	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BI315_03540	COG3291	Pkd domain containing protein
BI315_03545	COG0405	Gamma-glutamyltransferase
BI315_03550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BI315_03565	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BI315_03570	COG0742	ribosomal rna small subunit methyltransferase
BI315_03575	COG0326	Molecular chaperone. Has ATPase activity
BI315_03655	COG0531	amino acid
BI315_03670	COG0006	proline dipeptidase activity
BI315_03680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI315_03695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI315_03700	COG3938	Belongs to the proline racemase family
BI315_03710	COG0552	protein localization to endoplasmic reticulum
BI315_03720	COG1194	a g-specific adenine glycosylase
BI315_03725	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BI315_03730	COG0784	Response regulator, receiver
BI315_03730	COG4191	Histidine kinase
BI315_03745	COG0322	excinuclease ABC activity
BI315_03760	COG3040	lipid binding
BI315_03775	COG1960	acyl-CoA dehydrogenase activity
BI315_03785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BI315_03805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI315_03810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI315_03815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI315_03850	COG0438	transferase activity, transferring glycosyl groups
BI315_03855	COG0438	transferase activity, transferring glycosyl groups
BI315_03900	COG0776	regulation of translation
BI315_03905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI315_03905	COG0072	phenylalanine-tRNA ligase activity
BI315_03910	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BI315_03915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BI315_03920	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BI315_03925	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BI315_03930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BI315_03955	COG1082	Xylose isomerase domain protein TIM barrel
BI315_03980	COG0366	Alpha amylase catalytic
BI315_03985	COG2963	transposase activity
BI315_04045	COG3702	type iv secretory pathway
BI315_04065	COG2948	multi-organism process
BI315_04085	COG3505	Type IV secretory pathway VirD4
BI315_04100	COG0556	nucleotide-excision repair
BI315_04195	COG4695	Portal protein
BI315_04240	COG3179	chitinase
BI315_04340	COG3275	phosphorelay sensor kinase activity
BI315_04345	COG1611	Belongs to the LOG family
BI315_04360	COG2095	MarC family integral membrane protein
BI315_04370	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BI315_04375	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BI315_04405	COG1185	polyribonucleotide nucleotidyltransferase activity
BI315_04410	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BI315_04415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BI315_04420	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BI315_04425	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BI315_04430	COG0195	Participates in both transcription termination and antitermination
BI315_04435	COG0779	Required for maturation of 30S ribosomal subunits
BI315_04445	COG1007	ATP synthesis coupled electron transport
BI315_04460	COG0713	ATP synthesis coupled electron transport
BI315_04470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI315_04475	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BI315_04485	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BI315_04490	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BI315_04495	COG0649	NAD binding
BI315_04500	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI315_04505	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI315_04510	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI315_04525	COG0149	triose-phosphate isomerase activity
BI315_04530	COG0300	oxidoreductase activity
BI315_04560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BI315_04565	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BI315_04570	COG0159	tryptophan synthase activity
BI315_04580	COG0133	tryptophan synthase activity
BI315_04590	COG0135	phosphoribosylanthranilate isomerase activity
BI315_04595	COG0101	tRNA pseudouridine synthase activity
BI315_04615	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BI315_04620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BI315_04625	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BI315_04630	COG2890	protein-(glutamine-N5) methyltransferase activity
BI315_04640	COG0688	phosphatidylethanolamine metabolic process
BI315_04655	COG0433	COG0433 Predicted ATPase
BI315_04660	COG0494	nUDIX hydrolase
BI315_04680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI315_04685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BI315_04710	COG0717	Belongs to the dCTP deaminase family
BI315_04720	COG0489	protein tyrosine kinase activity
BI315_04740	COG3590	peptidase
BI315_04750	COG3590	peptidase
BI315_04770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI315_04775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI315_04780	COG2311	Membrane
BI315_04785	COG1047	Peptidyl-prolyl cis-trans
BI315_04790	COG0791	NLP P60 protein
BI315_04795	COG0791	NLP P60 protein
BI315_04805	COG4106	trans-aconitate 2-methyltransferase activity
BI315_04810	COG1301	dicarboxylic acid transport
BI315_04815	COG1785	Belongs to the alkaline phosphatase family
BI315_04825	COG0037	tRNA processing
BI315_04830	COG1722	exodeoxyribonuclease VII activity
BI315_04835	COG0142	geranyltranstransferase activity
BI315_04840	COG4104	PAAR repeat-containing protein
BI315_04850	COG0312	modulator of DNA gyrase
BI315_04855	COG3028	Belongs to the UPF0307 family
BI315_04860	COG0312	modulator of DNA gyrase
BI315_04870	COG3164	Protein of unknown function
BI315_04875	COG1530	ribonuclease E activity
BI315_04880	COG0424	maF-like protein
BI315_04885	COG2968	Membrane
BI315_04900	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BI315_04915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BI315_04930	COG0495	leucyl-tRNA aminoacylation
BI315_04940	COG3118	belongs to the thioredoxin family
BI315_04970	COG2155	Conserved Protein
BI315_04975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BI315_05015	COG1132	(ABC) transporter
BI315_05045	COG1538	Outer membrane efflux protein
BI315_05050	COG0745	RESPONSE REGULATOR receiver
BI315_05055	COG5002	protein histidine kinase activity
BI315_05055	COG5000	phosphorelay sensor kinase activity
BI315_05060	COG0475	glutathione-regulated potassium exporter activity
BI315_05065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BI315_05070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BI315_05090	COG3706	GGDEF domain
BI315_05090	COG0745	RESPONSE REGULATOR receiver
BI315_05095	COG1187	pseudouridine synthase activity
BI315_05100	COG5002	protein histidine kinase activity
BI315_05100	COG5001	Diguanylate cyclase
BI315_05225	COG0667	Aldo Keto reductase
BI315_05235	COG2814	Major facilitator Superfamily
BI315_05240	COG0583	DNA-binding transcription factor activity
BI315_05250	COG2207	Transcriptional regulator
BI315_05260	COG1309	transcriptional regulator
BI315_05265	COG1538	Outer membrane efflux protein
BI315_05285	COG0735	belongs to the Fur family
BI315_05290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI315_05315	COG4452	Inner membrane protein CreD
BI315_05325	COG2205	protein histidine kinase activity
BI315_05330	COG0745	RESPONSE REGULATOR receiver
BI315_05335	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BI315_05345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BI315_05380	COG2198	Histidine kinase
BI315_05380	COG0643	Histidine kinase
BI315_05390	COG0840	transmembrane signaling receptor activity
BI315_05395	COG0835	chemotaxis
BI315_05400	COG2200	EAL domain
BI315_05400	COG2202	Pas domain
BI315_05400	COG2199	diguanylate cyclase activity
BI315_05405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BI315_05410	COG2201	protein-glutamate methylesterase activity
BI315_05415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI315_05420	COG3590	peptidase
BI315_05430	COG0588	phosphoglycerate mutase activity
BI315_05435	COG1515	deoxyribonuclease V activity
BI315_05445	COG1741	Belongs to the pirin family
BI315_05460	COG1741	Belongs to the pirin family
BI315_05465	COG1966	Carbon starvation protein
BI315_05470	COG2879	small protein
BI315_05515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI315_05520	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BI315_05525	COG2080	2 iron, 2 sulfur cluster binding
BI315_05535	COG5001	Diguanylate cyclase
BI315_05535	COG4251	negative regulation of phosphorylation
BI315_05535	COG2203	Gaf domain
BI315_05535	COG3706	GGDEF domain
BI315_05540	COG0629	single-stranded DNA binding
BI315_05545	COG0142	geranyltranstransferase activity
BI315_05560	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BI315_05575	COG0527	aspartate kinase activity
BI315_05580	COG0384	phenazine biosynthesis protein PhzF
BI315_05585	COG0384	phenazine biosynthesis protein PhzF
BI315_05595	COG1764	response to oxidative stress
BI315_05600	COG0540	Belongs to the ATCase OTCase family
BI315_05605	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BI315_05610	COG1678	Uncharacterized ACR, COG1678
BI315_05620	COG0519	Catalyzes the synthesis of GMP from XMP
BI315_05630	COG5297	Belongs to the glycosyl hydrolase family 6
BI315_05645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BI315_05660	COG0739	heme binding
BI315_05680	COG0693	protein deglycase activity
BI315_05690	COG1959	2 iron, 2 sulfur cluster binding
BI315_05695	COG0719	Fe-S assembly protein
BI315_05700	COG0396	ATPase activity
BI315_05705	COG0719	Fe-S assembly protein
BI315_05710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BI315_05725	COG4774	siderophore transport
BI315_05730	COG3128	pkhd-type hydroxylase
BI315_05755	COG1477	protein flavinylation
BI315_05760	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BI315_05775	COG1555	photosystem II stabilization
BI315_05780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI315_05790	COG3178	'Phosphotransferase
BI315_05795	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BI315_05805	COG0628	permease
BI315_05815	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BI315_05825	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BI315_05845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BI315_05850	COG0271	Belongs to the BolA IbaG family
BI315_05860	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BI315_05870	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BI315_05875	COG1137	ATPase activity
BI315_05890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI315_05895	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BI315_05900	COG1660	Displays ATPase and GTPase activities
BI315_05910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI315_05915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BI315_05920	COG2239	Acts as a magnesium transporter
BI315_05935	COG1294	oxidase, subunit
BI315_05940	COG1271	oxidase subunit
BI315_05950	COG1113	amino acid transport
BI315_05980	COG2197	response regulator
BI315_05985	COG0531	amino acid
BI315_06020	COG1234	tRNA 3'-trailer cleavage
BI315_06065	COG2814	Major facilitator Superfamily
BI315_06075	COG0754	glutathionylspermidine amidase activity
BI315_06100	COG1842	Phage shock protein A
BI315_06110	COG0259	pyridoxamine-phosphate oxidase activity
BI315_06115	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BI315_06120	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BI315_06130	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BI315_06205	COG2814	Major facilitator Superfamily
BI315_06230	COG2205	protein histidine kinase activity
BI315_06230	COG0784	Response regulator, receiver
BI315_06230	COG2198	Histidine kinase
BI315_06235	COG2353	YceI-like domain
BI315_06255	COG1760	l-serine dehydratase
BI315_06270	COG0527	aspartate kinase activity
BI315_06270	COG0460	homoserine dehydrogenase
BI315_06275	COG0626	cystathionine gamma-synthase activity
BI315_06280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI315_06285	COG0739	heme binding
BI315_06290	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BI315_06295	COG1272	protein, Hemolysin III
BI315_06300	COG2982	Protein involved in outer membrane biogenesis
BI315_06305	COG0516	GMP reductase activity
BI315_06305	COG0517	IMP dehydrogenase activity
BI315_06310	COG0463	Glycosyl transferase, family 2
BI315_06315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI315_06320	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BI315_06330	COG4771	TonB-dependent receptor
BI315_06340	COG1309	transcriptional regulator
BI315_06345	COG2267	carboxylic ester hydrolase activity
BI315_06350	COG1960	acyl-CoA dehydrogenase activity
BI315_06375	COG0509	glycine decarboxylation via glycine cleavage system
BI315_06380	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BI315_06390	COG0330	HflC and HflK could
BI315_06395	COG1742	UPF0060 membrane protein
BI315_06400	COG3956	TIGRFAM MazG family protein
BI315_06410	COG0494	nUDIX hydrolase
BI315_06420	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BI315_06425	COG0837	glucose binding
BI315_06440	COG1388	LysM domain
BI315_06440	COG3858	chitin binding
BI315_06455	COG1472	Belongs to the glycosyl hydrolase 3 family
BI315_06470	COG0531	amino acid
BI315_06480	COG1486	melibiose metabolic process
BI315_06490	COG3537	Alpha-1,2-mannosidase
BI315_06530	COG3142	Participates in the control of copper homeostasis
BI315_06535	COG1446	asparaginase
BI315_06575	COG0840	transmembrane signaling receptor activity
BI315_06595	COG0189	ligase activity
BI315_06605	COG1397	ADP-ribosylglycohydrolase
BI315_06615	COG1199	ATP-dependent helicase activity
BI315_06625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI315_06630	COG1215	transferase activity, transferring glycosyl groups
BI315_06650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BI315_06660	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BI315_06665	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
BI315_06670	COG0535	radical SAM domain protein
BI315_06675	COG0535	radical SAM domain protein
BI315_06690	COG0837	glucose binding
BI315_06705	COG1643	Atp-dependent helicase
BI315_06710	COG0783	Belongs to the Dps family
BI315_06720	COG0514	ATP-dependent DNA helicase (RecQ)
BI315_06755	COG0840	transmembrane signaling receptor activity
BI315_06775	COG3920	Histidine kinase
BI315_06780	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BI315_06790	COG0602	queuosine metabolic process
BI315_06800	COG2885	chlorophyll binding
BI315_06805	COG0823	Involved in the tonB-independent uptake of proteins
BI315_06815	COG0848	biopolymer transport protein
BI315_06825	COG0824	Thioesterase
BI315_06830	COG2255	four-way junction helicase activity
BI315_06840	COG3158	transport of potassium into the cell
BI315_06845	COG0632	four-way junction helicase activity
BI315_06850	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BI315_06855	COG0217	transcriptional regulatory protein
BI315_06870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BI315_06885	COG0477	Major facilitator Superfamily
BI315_06930	COG0488	(ABC) transporter
BI315_06970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BI315_06970	COG4651	solute:proton antiporter activity
BI315_06995	COG4772	TonB-dependent receptor
BI315_07005	COG4264	IucA IucC family
BI315_07020	COG0019	diaminopimelate decarboxylase activity
BI315_07045	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BI315_07055	COG1492	cobalamin metabolic process
BI315_07065	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BI315_07085	COG4206	TonB-dependent receptor
BI315_07090	COG0542	response to heat
BI315_07095	COG1116	anion transmembrane transporter activity
BI315_07100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI315_07105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BI315_07110	COG0667	Aldo Keto reductase
BI315_07120	COG4771	TonB-dependent receptor
BI315_07125	COG2827	Endonuclease containing a URI domain
BI315_07165	COG1877	trehalose-phosphatase activity
BI315_07170	COG3387	PFAM Glycoside hydrolase 15-related
BI315_07190	COG0840	transmembrane signaling receptor activity
BI315_07195	COG3011	Protein conserved in bacteria
BI315_07210	COG0564	pseudouridine synthase activity
BI315_07215	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI315_07225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BI315_07225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BI315_07255	COG2951	lytic endotransglycosylase activity
BI315_07260	COG4644	lycopene metabolic process
BI315_07285	COG2369	cell adhesion
BI315_07310	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BI315_07315	COG0045	succinate-CoA ligase (ADP-forming) activity
BI315_07330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI315_07365	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BI315_07370	COG0237	dephospho-CoA kinase activity
BI315_07400	COG5002	protein histidine kinase activity
BI315_07405	COG0745	RESPONSE REGULATOR receiver
BI315_07490	COG2003	Belongs to the UPF0758 family
BI315_07515	COG0784	Response regulator, receiver
BI315_07515	COG4191	Histidine kinase
BI315_07520	COG0784	Response regulator, receiver
BI315_07520	COG4191	Histidine kinase
BI315_07645	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BI315_07675	COG2022	thiamine diphosphate biosynthetic process
BI315_07685	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BI315_07690	COG0471	metal ion transport
BI315_07690	COG3273	potassium ion transport
BI315_07715	COG1970	mechanosensitive ion channel activity
BI315_07725	COG1609	Transcriptional regulator
BI315_07735	COG3250	beta-galactosidase activity
BI315_07740	COG4948	Mandelate Racemase Muconate Lactonizing
BI315_07755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI315_07765	COG0308	aminopeptidase N
BI315_07805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI315_07815	COG2895	sulfate adenylyltransferase (ATP) activity
BI315_07815	COG0529	Catalyzes the synthesis of activated sulfate
BI315_07820	COG0175	sulfate reduction
BI315_07825	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BI315_07830	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BI315_07835	COG0175	sulfate reduction
BI315_07875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BI315_07875	COG1648	precorrin-2 dehydrogenase activity
BI315_07890	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BI315_07895	COG3588	fructose-bisphosphate aldolase
BI315_07910	COG0469	pyruvate kinase activity
BI315_07920	COG0126	phosphoglycerate kinase activity
BI315_07945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BI315_07955	COG3047	cAMP biosynthetic process
BI315_07960	COG3047	cAMP biosynthetic process
BI315_07970	COG3453	Protein conserved in bacteria
BI315_07970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI315_07975	COG0725	ABC transporter, periplasmic molybdate-binding protein
BI315_07980	COG4149	molybdate abc transporter
BI315_07985	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BI315_08020	COG1376	ErfK ybiS ycfS ynhG family protein
BI315_08025	COG0739	heme binding
BI315_08035	COG4773	Receptor
BI315_08040	COG0596	Alpha beta hydrolase
BI315_08045	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BI315_08050	COG1301	dicarboxylic acid transport
BI315_08065	COG2304	oxidoreductase activity
BI315_08085	COG0714	Associated with various cellular activities
BI315_08120	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BI315_08135	COG0254	rRNA binding
BI315_08145	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BI315_08155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BI315_08160	COG1758	RNA polymerase activity
BI315_08165	COG0194	GDP metabolic process
BI315_08170	COG1561	YicC-like family, N-terminal region
BI315_08175	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BI315_08185	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BI315_08190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BI315_08205	COG0006	proline dipeptidase activity
BI315_08215	COG0006	proline dipeptidase activity
BI315_08220	COG3079	Belongs to the UPF0149 family
BI315_08240	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BI315_08250	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BI315_08260	COG2912	Transglutaminase-like superfamily
BI315_08265	COG1773	rubredoxin
BI315_08270	COG0352	thiamine-phosphate diphosphorylase activity
BI315_08285	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BI315_08300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI315_08330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BI315_08335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI315_08345	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_08355	COG0671	phosphoesterase, PA-phosphatase related
BI315_08360	COG3781	membrane
BI315_08370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BI315_08375	COG0563	adenylate kinase activity
BI315_08390	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BI315_08400	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BI315_08420	COG3710	Transcriptional regulator
BI315_08425	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BI315_08440	COG0840	transmembrane signaling receptor activity
BI315_08445	COG0405	Gamma-glutamyltransferase
BI315_08450	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BI315_08470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BI315_08475	COG0473	3-isopropylmalate dehydrogenase activity
BI315_08480	COG0066	3-isopropylmalate dehydratase activity
BI315_08485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BI315_08505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BI315_08510	COG1538	Outer membrane efflux protein
BI315_08515	COG1519	Transferase
BI315_08525	COG1560	Kdo2-lipid A biosynthetic process
BI315_08550	COG0280	phosphate acetyltransferase
BI315_08550	COG0281	malic enzyme
BI315_08555	COG1301	dicarboxylic acid transport
BI315_08580	COG0583	DNA-binding transcription factor activity
BI315_08590	COG0667	Aldo Keto reductase
BI315_08605	COG2197	response regulator
BI315_08615	COG1840	ABC-type Fe3 transport system, periplasmic component
BI315_08620	COG0642	Histidine kinase
BI315_08640	COG2851	Citrate transporter
BI315_08645	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_08650	COG1609	Transcriptional regulator
BI315_08655	COG2211	Major facilitator Superfamily
BI315_08680	COG1162	GTPase activity
BI315_08710	COG4773	Receptor
BI315_08715	COG0726	polysaccharide deacetylase
BI315_08720	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BI315_08735	COG2963	transposase activity
BI315_08740	COG2801	Transposase and inactivated derivatives
BI315_08765	COG1307	EDD domain protein, DegV family
BI315_08770	COG0242	peptide deformylase activity
BI315_08800	COG0457	Tetratricopeptide repeat
BI315_08805	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BI315_08810	COG1215	transferase activity, transferring glycosyl groups
BI315_08815	COG1215	transferase activity, transferring glycosyl groups
BI315_08830	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BI315_08885	COG2188	Transcriptional regulator
BI315_08895	COG1450	Type ii and iii secretion system protein
BI315_08910	COG3166	PFAM Fimbrial assembly family protein
BI315_08915	COG3156	type II secretion system protein K
BI315_08920	COG4795	General secretion pathway protein
BI315_08925	COG2165	general secretion pathway protein
BI315_08930	COG4970	Tfp pilus assembly protein FimT
BI315_08935	COG2165	general secretion pathway protein
BI315_08940	COG1459	type II secretion system
BI315_08950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI315_08955	COG1404	Belongs to the peptidase S8 family
BI315_08960	COG5295	Hep Hag repeat protein
BI315_08965	COG1404	Belongs to the peptidase S8 family
BI315_08970	COG5295	Hep Hag repeat protein
BI315_08980	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BI315_08980	COG0047	phosphoribosylformylglycinamidine synthase activity
BI315_08995	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BI315_09005	COG4974	Belongs to the 'phage' integrase family
BI315_09020	COG0795	lipopolysaccharide-transporting ATPase activity
BI315_09030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BI315_09045	COG0525	valine-tRNA ligase activity
BI315_09075	COG1183	phosphatidylcholine synthase activity
BI315_09085	COG0442	prolyl-tRNA aminoacylation
BI315_09100	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BI315_09105	COG1127	ABC transporter
BI315_09110	COG3218	ABC-type transport auxiliary lipoprotein component
BI315_09110	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BI315_09145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BI315_09150	COG0662	Cupin 2, conserved barrel domain protein
BI315_09150	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BI315_09185	COG2086	electron transfer activity
BI315_09200	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BI315_09200	COG0546	phosphoglycolate phosphatase activity
BI315_09205	COG0277	FAD linked oxidase domain protein
BI315_09220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI315_09250	COG0438	transferase activity, transferring glycosyl groups
BI315_09250	COG1216	Glycosyl transferase, family 2
BI315_09270	COG0626	cystathionine gamma-synthase activity
BI315_09305	COG0625	glutathione transferase activity
BI315_09320	COG0513	Belongs to the DEAD box helicase family
BI315_09330	COG4206	TonB-dependent receptor
BI315_09340	COG0720	synthase
BI315_09350	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BI315_09355	COG1956	GAF domain-containing protein
BI315_09365	COG2819	hydrolase of the alpha beta superfamily
BI315_09380	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BI315_09385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI315_09400	COG0339	signal peptide processing
BI315_09415	COG2132	Multicopper oxidase
BI315_09455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BI315_09460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI315_09465	COG1136	(ABC) transporter
BI315_09465	COG4591	ABC-type transport system involved in lipoprotein release permease component
BI315_09470	COG1136	(ABC) transporter
BI315_09470	COG0577	efflux transmembrane transporter activity
BI315_09475	COG0577	efflux transmembrane transporter activity
BI315_09495	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BI315_09510	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BI315_09515	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BI315_09520	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BI315_09525	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BI315_09530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BI315_09535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BI315_09545	COG0356	it plays a direct role in the translocation of protons across the membrane
BI315_09565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI315_09575	COG0508	dehydrogenase complex catalyzes the overall conversion of
BI315_09615	COG2011	ABC-type metal ion transport system permease component
BI315_09620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BI315_09625	COG0697	spore germination
BI315_09630	COG1666	GTP binding
BI315_09640	COG0784	Response regulator, receiver
BI315_09640	COG2198	Histidine kinase
BI315_09640	COG5002	protein histidine kinase activity
BI315_09660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BI315_09665	COG1187	pseudouridine synthase activity
BI315_09670	COG2813	Specifically methylates the guanine in position
BI315_09690	COG2202	Pas domain
BI315_09690	COG2205	protein histidine kinase activity
BI315_09710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BI315_09715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI315_09720	COG1522	sequence-specific DNA binding
BI315_09780	COG0842	Transport permease protein
BI315_09785	COG1131	(ABC) transporter
BI315_09790	COG0025	NhaP-type Na H and K H
BI315_09800	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BI315_09805	COG1573	uracil-dna glycosylase
BI315_09815	COG3384	dioxygenase
BI315_09825	COG0583	DNA-binding transcription factor activity
BI315_09835	COG0667	Aldo Keto reductase
BI315_09870	COG0531	amino acid
BI315_09885	COG2972	Histidine kinase
BI315_09910	COG3685	Protein conserved in bacteria
BI315_09915	COG3546	catalase activity
BI315_09950	COG2204	response regulator
BI315_09965	COG1271	oxidase subunit
BI315_09970	COG1294	oxidase, subunit
BI315_09985	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_09990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BI315_10010	COG1132	(ABC) transporter
BI315_10025	COG1063	alcohol dehydrogenase
BI315_10100	COG0251	oxidation-reduction process
BI315_10130	COG0840	transmembrane signaling receptor activity
BI315_10150	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BI315_10195	COG0024	Methionine aminopeptidase
BI315_10230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BI315_10235	COG1490	D-aminoacyl-tRNA deacylase activity
BI315_10240	COG1560	Kdo2-lipid A biosynthetic process
BI315_10295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BI315_10295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BI315_10300	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BI315_10305	COG0242	peptide deformylase activity
BI315_10310	COG1652	LysM domain
BI315_10315	COG0758	DNA mediated transformation
BI315_10320	COG2922	Belongs to the Smg family
BI315_10335	COG1754	DNA topoisomerase type I activity
BI315_10335	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BI315_10340	COG0009	L-threonylcarbamoyladenylate synthase
BI315_10355	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_10365	COG0616	signal peptide processing
BI315_10370	COG0534	Mate efflux family protein
BI315_10390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BI315_10395	COG0625	glutathione transferase activity
BI315_10410	COG1252	NADH dehydrogenase
BI315_10415	COG2860	membrane
BI315_10420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BI315_10425	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BI315_10430	COG3437	response regulator, receiver
BI315_10435	COG2177	Part of the ABC transporter FtsEX involved in
BI315_10440	COG2884	Cell division ATP-binding protein ftsE
BI315_10445	COG0513	Belongs to the DEAD box helicase family
BI315_10450	COG3118	belongs to the thioredoxin family
BI315_10455	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BI315_10460	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BI315_10465	COG0583	DNA-binding transcription factor activity
BI315_10510	COG1518	maintenance of DNA repeat elements
BI315_10515	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BI315_10525	COG1652	LysM domain
BI315_10530	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BI315_10530	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BI315_10535	COG1473	amidohydrolase
BI315_10540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI315_10545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI315_10555	COG5383	Protein conserved in bacteria
BI315_10600	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BI315_10605	COG3023	N-Acetylmuramoyl-L-alanine amidase
BI315_10615	COG4948	Mandelate Racemase Muconate Lactonizing
BI315_10625	COG0531	amino acid
BI315_10640	COG4682	membrane
BI315_10645	COG2133	pyrroloquinoline quinone binding
BI315_10655	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BI315_10660	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BI315_10665	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BI315_10670	COG1610	YqeY-like protein
BI315_10680	COG1295	ribonuclease BN
BI315_10685	COG0358	DNA primase activity
BI315_10700	COG0109	protoheme IX farnesyltransferase activity
BI315_10730	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BI315_10745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BI315_10790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BI315_10795	COG0739	heme binding
BI315_10800	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BI315_10810	COG2211	Major facilitator Superfamily
BI315_10815	COG0708	Exodeoxyribonuclease III
BI315_10820	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BI315_10830	COG1192	Involved in chromosome partitioning
BI315_10835	COG1475	DNA binding
BI315_10855	COG0463	Glycosyl transferase, family 2
BI315_10875	COG0756	dUTP diphosphatase activity
BI315_10880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BI315_10885	COG2003	Belongs to the UPF0758 family
BI315_10890	COG0018	arginyl-trna synthetase
BI315_10905	COG4221	oxidoreductase activity
BI315_10910	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BI315_10910	COG2755	lipolytic protein G-D-S-L family
BI315_10920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BI315_10925	COG1166	arginine decarboxylase activity
BI315_10930	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BI315_10970	COG0606	chelatase, subunit chli
BI315_10985	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BI315_11025	COG1690	Belongs to the RtcB family
BI315_11060	COG1090	epimerase
BI315_11065	COG0745	RESPONSE REGULATOR receiver
BI315_11070	COG0642	Histidine kinase
BI315_11100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI315_11125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BI315_11130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BI315_11145	COG0753	catalase activity
BI315_11160	COG2197	response regulator
BI315_11165	COG4585	Histidine kinase
BI315_11170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI315_11175	COG1136	(ABC) transporter
BI315_11200	COG0697	spore germination
BI315_11220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI315_11225	COG0180	Tryptophanyl-tRNA synthetase
BI315_11230	COG3237	CsbD-like
BI315_11275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BI315_11290	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BI315_11325	COG2205	protein histidine kinase activity
BI315_11330	COG0745	RESPONSE REGULATOR receiver
BI315_11340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BI315_11380	COG1199	ATP-dependent helicase activity
BI315_11395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BI315_11460	COG0625	glutathione transferase activity
BI315_11500	COG4555	ABC transporter
BI315_11510	COG1476	TRANSCRIPTIONal
BI315_11555	COG0543	2 iron, 2 sulfur cluster binding
BI315_11555	COG0633	Ferredoxin
BI315_11560	COG1131	(ABC) transporter
BI315_11565	COG0842	Transport permease protein
BI315_11575	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BI315_11610	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI315_11620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI315_11635	COG1042	CoA-binding domain protein
BI315_11635	COG0045	succinate-CoA ligase (ADP-forming) activity
BI315_11635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BI315_11640	COG2239	Acts as a magnesium transporter
BI315_11660	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BI315_11665	COG3387	PFAM Glycoside hydrolase 15-related
BI315_11680	COG3100	YcgL domain-containing protein
BI315_11685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BI315_11695	COG0463	Glycosyl transferase, family 2
BI315_11715	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_11755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI315_11770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BI315_11800	COG4946	Tricorn protease homolog
BI315_11800	COG1506	peptidase
BI315_11800	COG0823	Involved in the tonB-independent uptake of proteins
BI315_11820	COG0408	coproporphyrinogen oxidase activity
BI315_11860	COG0515	serine threonine protein kinase
BI315_11860	COG2815	serine threonine protein kinase
BI315_11865	COG0631	protein serine/threonine phosphatase activity
BI315_11900	COG3501	Rhs element vgr protein
BI315_12035	COG0210	DNA helicase
BI315_12050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI315_12055	COG0583	DNA-binding transcription factor activity
BI315_12060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BI315_12075	COG2159	amidohydrolase
BI315_12080	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BI315_12085	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BI315_12095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI315_12115	COG0357	Ribosomal RNA small subunit methyltransferase G
BI315_12120	COG3540	Alkaline phosphatase
BI315_12130	COG2091	lysine biosynthetic process via aminoadipic acid
BI315_12145	COG0708	Exodeoxyribonuclease III
BI315_12150	COG1846	Transcriptional regulator
BI315_12150	COG1940	carbohydrate kinase activity
BI315_12160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI315_12170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BI315_12175	COG3162	membrane
BI315_12185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BI315_12215	COG3507	Belongs to the glycosyl hydrolase 43 family
BI315_12235	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_12240	COG0179	Fumarylacetoacetate (FAA) hydrolase
BI315_12250	COG4948	Mandelate Racemase Muconate Lactonizing
BI315_12260	COG3254	rhamnose metabolic process
BI315_12265	COG0738	Major facilitator superfamily
BI315_12270	COG1414	Transcriptional regulator
BI315_12275	COG1971	Probably functions as a manganese efflux pump
BI315_12280	COG2205	protein histidine kinase activity
BI315_12295	COG3459	Glycosyltransferase 36 associated
BI315_12300	COG2211	Major facilitator Superfamily
BI315_12305	COG3265	gluconokinase activity
BI315_12315	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI315_12335	COG2911	Protein conserved in bacteria
BI315_12340	COG0729	surface antigen
BI315_12375	COG0752	glycyl-tRNA synthetase alpha subunit
BI315_12380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI315_12395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BI315_12395	COG0519	Catalyzes the synthesis of GMP from XMP
BI315_12405	COG0805	protein transport
BI315_12410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BI315_12415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BI315_12425	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BI315_12450	COG2974	May be involved in recombination
BI315_12455	COG0037	tRNA processing
BI315_12465	COG2115	Belongs to the xylose isomerase family
BI315_12475	COG3661	Belongs to the glycosyl hydrolase 67 family
BI315_12485	COG4948	Mandelate Racemase Muconate Lactonizing
BI315_12495	COG1472	Belongs to the glycosyl hydrolase 3 family
BI315_12500	COG0246	Mannitol dehydrogenase
BI315_12575	COG3386	PFAM SMP-30 Gluconolaconase
BI315_12585	COG3250	beta-galactosidase activity
BI315_12605	COG3693	PFAM glycoside hydrolase, family 10
BI315_12620	COG2211	Major facilitator Superfamily
BI315_12685	COG2937	Belongs to the GPAT DAPAT family
BI315_12720	COG0284	orotidine-5'-phosphate decarboxylase activity
BI315_12725	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BI315_12735	COG3132	Protein of unknown function, DUF480
BI315_12750	COG0210	DNA helicase
BI315_12755	COG1435	thymidine kinase activity
BI315_12765	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BI315_12775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BI315_12810	COG3135	benzoate transporter
BI315_12830	COG0676	glucose-6-phosphate 1-epimerase activity
BI315_12840	COG3012	SEC-C Motif Domain Protein
BI315_12845	COG0730	response to heat
BI315_12865	COG0302	gtp cyclohydrolase
BI315_12880	COG1566	PFAM secretion protein HlyD family protein
BI315_12890	COG1289	transmembrane transporter activity
BI315_12895	COG0477	Major facilitator Superfamily
BI315_12905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI315_12925	COG4691	Plasmid stability protein
BI315_12930	COG1487	ribonuclease activity
BI315_12955	COG0564	pseudouridine synthase activity
BI315_12995	COG0439	Biotin carboxylase
BI315_13045	COG1074	ATP-dependent DNA helicase activity
BI315_13050	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BI315_13065	COG1127	ABC transporter
BI315_13070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BI315_13075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BI315_13090	COG2853	Lipoprotein
BI315_13100	COG0386	Belongs to the glutathione peroxidase family
BI315_13110	COG1322	Protein conserved in bacteria
BI315_13115	COG0604	alcohol dehydrogenase
BI315_13120	COG0583	DNA-binding transcription factor activity
BI315_13135	COG0625	glutathione transferase activity
BI315_13145	COG0531	amino acid
BI315_13150	COG3537	Alpha-1,2-mannosidase
BI315_13165	COG3706	GGDEF domain
BI315_13170	COG3835	regulator
BI315_13175	COG1929	Belongs to the glycerate kinase type-1 family
BI315_13180	COG2271	Major facilitator Superfamily
BI315_13195	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BI315_13205	COG0861	Integral membrane protein TerC family
BI315_13220	COG0584	glycerophosphoryl diester phosphodiesterase
BI315_13235	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BI315_13240	COG0726	polysaccharide deacetylase
BI315_13245	COG0706	membrane insertase activity
BI315_13250	COG0594	ribonuclease P activity
BI315_13255	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BI315_13265	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BI315_13275	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BI315_13280	COG0187	DNA topoisomerase II activity
BI315_13290	COG0501	Belongs to the peptidase M48B family
BI315_13320	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BI315_13330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI315_13375	COG0793	Belongs to the peptidase S41A family
BI315_13380	COG4942	peptidase
BI315_13390	COG2234	aminopeptidase activity
BI315_13400	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI315_13410	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI315_13415	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI315_13425	COG1064	alcohol dehydrogenase
BI315_13435	COG0493	'glutamate synthase
BI315_13440	COG0070	glutamate synthase
BI315_13440	COG0069	glutamate synthase activity
BI315_13440	COG0067	glutamate synthase
BI315_13490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BI315_13505	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BI315_13510	COG0438	transferase activity, transferring glycosyl groups
BI315_13510	COG0297	glycogen (starch) synthase activity
BI315_13530	COG0367	asparagine synthase
BI315_13560	COG1132	(ABC) transporter
BI315_13685	COG1111	helicase
BI315_13685	COG1205	dead DEAH box helicase
BI315_13690	COG1272	protein, Hemolysin III
BI315_13715	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_13740	COG2249	NAD(P)H dehydrogenase (quinone) activity
BI315_13755	COG2801	Transposase and inactivated derivatives
BI315_13810	COG3237	CsbD-like
BI315_13860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI315_13870	COG0477	Major facilitator Superfamily
BI315_13910	COG0714	Associated with various cellular activities
BI315_13940	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BI315_13950	COG4772	TonB-dependent receptor
BI315_13960	COG0662	Cupin 2, conserved barrel domain protein
BI315_13965	COG1012	belongs to the aldehyde dehydrogenase family
BI315_13990	COG1304	FMN binding
BI315_14005	COG4585	Histidine kinase
BI315_14010	COG2197	response regulator
BI315_14030	COG3710	Transcriptional regulator
BI315_14035	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BI315_14125	COG0366	Alpha amylase catalytic
BI315_14130	COG0366	Alpha amylase catalytic
BI315_14135	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BI315_14160	COG0657	acetylesterase activity
BI315_14160	COG2755	lipolytic protein G-D-S-L family
BI315_14170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BI315_14185	COG3507	Belongs to the glycosyl hydrolase 43 family
BI315_14190	COG1609	Transcriptional regulator
BI315_14205	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BI315_14210	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_14220	COG2755	lipolytic protein G-D-S-L family
BI315_14235	COG3186	Phenylalanine-4-hydroxylase
BI315_14240	COG1522	sequence-specific DNA binding
BI315_14250	COG1752	Esterase of the alpha-beta hydrolase superfamily
BI315_14260	COG1119	ATPase activity
BI315_14275	COG1125	glycine betaine transport
BI315_14290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BI315_14310	COG1396	sequence-specific DNA binding
BI315_14335	COG0489	protein tyrosine kinase activity
BI315_14340	COG2062	phosphohistidine phosphatase, SixA
BI315_14350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI315_14395	COG1968	undecaprenyl-diphosphatase activity
BI315_14405	COG0174	glutamine synthetase
BI315_14410	COG0347	Belongs to the P(II) protein family
BI315_14415	COG0004	ammonium transporteR
BI315_14420	COG3852	Histidine kinase
BI315_14425	COG2204	response regulator
BI315_14430	COG2032	superoxide dismutase activity
BI315_14435	COG2032	superoxide dismutase activity
BI315_14445	COG0346	lactoylglutathione lyase activity
BI315_14455	COG0183	Belongs to the thiolase family
BI315_14490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BI315_14495	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BI315_14500	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BI315_14515	COG0028	Belongs to the TPP enzyme family
BI315_14520	COG2205	protein histidine kinase activity
BI315_14545	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BI315_14560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI315_14570	COG0596	Alpha beta hydrolase
BI315_14580	COG0318	PFAM AMP-dependent synthetase and ligase
BI315_14585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI315_14600	COG1181	Belongs to the D-alanine--D-alanine ligase family
BI315_14615	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BI315_14625	COG0564	pseudouridine synthase activity
BI315_14650	COG0339	signal peptide processing
BI315_14680	COG0475	glutathione-regulated potassium exporter activity
BI315_14685	COG0583	DNA-binding transcription factor activity
BI315_14690	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BI315_14695	COG2224	Isocitrate lyase
BI315_14700	COG3706	GGDEF domain
BI315_14730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BI315_14735	COG1960	acyl-CoA dehydrogenase activity
BI315_14795	COG0523	cobalamin synthesis protein
BI315_14805	COG0697	spore germination
BI315_14815	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BI315_14820	COG1846	Transcriptional regulator
BI315_14825	COG1764	response to oxidative stress
BI315_14855	COG2130	NADP-dependent
BI315_14870	COG1187	pseudouridine synthase activity
BI315_14885	COG1643	Atp-dependent helicase
BI315_14895	COG4807	Protein conserved in bacteria
BI315_14900	COG2351	hydroxyisourate hydrolase activity
BI315_14925	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BI315_14970	COG2252	PERMEase
BI315_14995	COG0084	hydrolase, TatD family'
BI315_15010	COG0583	DNA-binding transcription factor activity
BI315_15015	COG2814	Major facilitator Superfamily
BI315_15030	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BI315_15035	COG1902	pentaerythritol trinitrate reductase activity
BI315_15055	COG0745	RESPONSE REGULATOR receiver
BI315_15060	COG2205	protein histidine kinase activity
BI315_15065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI315_15075	COG1538	Outer membrane efflux protein
BI315_15085	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BI315_15090	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BI315_15095	COG0583	DNA-binding transcription factor activity
BI315_15130	COG0702	epimerase
BI315_15135	COG1733	regulation of RNA biosynthetic process
BI315_15175	COG0129	dihydroxy-acid dehydratase activity
BI315_15190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BI315_15245	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BI315_15250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BI315_15275	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BI315_15280	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BI315_15290	COG3485	protocatechuate 3,4-dioxygenase
BI315_15295	COG3485	protocatechuate 3,4-dioxygenase
BI315_15305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI315_15310	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BI315_15320	COG1414	Transcriptional regulator
BI315_15340	COG0445	tRNA wobble uridine modification
BI315_15380	COG2267	carboxylic ester hydrolase activity
BI315_15390	COG0156	8-amino-7-oxononanoate synthase activity
BI315_15395	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BI315_15400	COG1040	competence protein
BI315_15405	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BI315_15490	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BI315_15565	COG3264	Mechanosensitive ion channel
BI315_15565	COG1511	domain protein
BI315_15570	COG1368	sulfuric ester hydrolase activity
BI315_15580	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BI315_15585	COG2354	Protein conserved in bacteria
BI315_15590	COG3706	GGDEF domain
BI315_15590	COG0745	RESPONSE REGULATOR receiver
BI315_15595	COG0297	glycogen (starch) synthase activity
BI315_15600	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BI315_15605	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BI315_15630	COG0702	epimerase
BI315_15635	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_15670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI315_15675	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_15685	COG0513	Belongs to the DEAD box helicase family
BI315_15705	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BI315_15715	COG3483	tryptophan 2,3-dioxygenase activity
BI315_15720	COG3104	oligopeptide transport
BI315_15745	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BI315_15765	COG1320	monovalent cation:proton antiporter activity
BI315_15770	COG2212	antiporter activity
BI315_15780	COG0651	ATP synthesis coupled electron transport
BI315_15785	COG1006	Multisubunit Na H antiporter MnhC subunit
BI315_15790	COG2111	Na H antiporter
BI315_15790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BI315_15835	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BI315_15840	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BI315_15855	COG0456	acetyltransferase
BI315_15860	COG1597	lipid kinase activity
BI315_15885	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BI315_15890	COG0134	indole-3-glycerol-phosphate synthase activity
BI315_15900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI315_15905	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BI315_15915	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BI315_15920	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BI315_15925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BI315_15940	COG1051	belongs to the nudix hydrolase family
BI315_15980	COG0316	Belongs to the HesB IscA family
BI315_16010	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BI315_16025	COG2814	Major facilitator Superfamily
BI315_16030	COG0583	DNA-binding transcription factor activity
BI315_16035	COG2814	Major facilitator Superfamily
BI315_16040	COG1289	transmembrane transporter activity
BI315_16050	COG0151	Belongs to the GarS family
BI315_16060	COG0138	bifunctional purine biosynthesis protein purh
BI315_16065	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BI315_16070	COG2267	carboxylic ester hydrolase activity
BI315_16075	COG0671	phosphoesterase, PA-phosphatase related
BI315_16075	COG2453	phosphatase
BI315_16100	COG4589	Belongs to the CDS family
BI315_16105	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BI315_16125	COG2264	protein methyltransferase activity
BI315_16145	COG0439	Biotin carboxylase
BI315_16155	COG0511	ligase activity, forming carbon-carbon bonds
BI315_16160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BI315_16170	COG1324	tolerance protein
BI315_16200	COG0300	oxidoreductase activity
BI315_16205	COG2356	endonuclease I
BI315_16215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BI315_16220	COG0459	protein refolding
BI315_16235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BI315_16250	COG3386	PFAM SMP-30 Gluconolaconase
BI315_16260	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BI315_16265	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BI315_16285	COG0778	Nitroreductase
BI315_16290	COG2353	YceI-like domain
BI315_16320	COG3052	prosthetic group binding
BI315_16340	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
BI315_16345	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BI315_16355	COG1802	Transcriptional regulator
BI315_16405	COG2801	Transposase and inactivated derivatives
BI315_16415	COG4221	oxidoreductase activity
BI315_16430	COG4221	oxidoreductase activity
BI315_16440	COG0435	Glutathione S-transferase
BI315_16465	COG2409	Drug exporters of the RND superfamily
BI315_16475	COG1506	peptidase
BI315_16475	COG0823	Involved in the tonB-independent uptake of proteins
BI315_16490	COG3706	GGDEF domain
BI315_16515	COG0697	spore germination
BI315_16530	COG1113	amino acid transport
BI315_16540	COG0598	Magnesium transport protein CorA
BI315_16550	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
BI315_16600	COG0840	transmembrane signaling receptor activity
BI315_16605	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI315_16605	COG5297	Belongs to the glycosyl hydrolase family 6
BI315_16610	COG0659	secondary active sulfate transmembrane transporter activity
BI315_16620	COG3706	GGDEF domain
BI315_16640	COG2943	transferase activity, transferring hexosyl groups
BI315_16650	COG3275	phosphorelay sensor kinase activity
BI315_16660	COG0181	hydroxymethylbilane synthase activity
BI315_16690	COG1505	serine-type exopeptidase activity
BI315_16695	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BI315_16715	COG2832	Protein of unknown function (DUF454)
BI315_16725	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BI315_16735	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BI315_16740	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BI315_16745	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BI315_16770	COG2226	methyltransferase
BI315_16775	COG5001	Diguanylate cyclase
BI315_16775	COG3300	MHYT domain
BI315_16780	COG0308	aminopeptidase N
BI315_16830	COG3284	Transcriptional regulator
BI315_16840	COG1077	Cell shape determining protein MreB Mrl
BI315_16845	COG1792	Involved in formation and maintenance of cell shape
BI315_16860	COG0772	Belongs to the SEDS family
BI315_16870	COG2951	lytic endotransglycosylase activity
BI315_16875	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BI315_16885	COG1686	Belongs to the peptidase S11 family
BI315_16895	COG2921	Belongs to the UPF0250 family
BI315_16900	COG0321	lipoyl(octanoyl) transferase activity
BI315_16905	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BI315_16920	COG0583	DNA-binding transcription factor activity
BI315_16930	COG1051	belongs to the nudix hydrolase family
BI315_16930	COG1056	cytidyltransferase-related domain
BI315_16965	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BI315_16970	COG0673	inositol 2-dehydrogenase activity
BI315_16975	COG2823	Periplasmic or secreted lipoprotein
BI315_16980	COG4251	negative regulation of phosphorylation
BI315_16985	COG0784	Response regulator, receiver
BI315_16990	COG4191	Histidine kinase
BI315_16995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BI315_17055	COG1459	type II secretion system
BI315_17130	COG1609	Transcriptional regulator
BI315_17135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BI315_17140	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BI315_17150	COG0617	tRNA 3'-terminal CCA addition
BI315_17155	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BI315_17160	COG1012	belongs to the aldehyde dehydrogenase family
BI315_17165	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BI315_17180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BI315_17195	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BI315_17200	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BI315_17220	COG2205	protein histidine kinase activity
BI315_17225	COG0745	RESPONSE REGULATOR receiver
BI315_17250	COG3791	Glutathione-dependent formaldehyde-activating
BI315_17265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI315_17275	COG0697	spore germination
BI315_17285	COG0488	(ABC) transporter
BI315_17295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BI315_17300	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BI315_17310	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI315_17310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI315_17330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BI315_17335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BI315_17340	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BI315_17365	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BI315_17370	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BI315_17375	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BI315_17380	COG2205	protein histidine kinase activity
BI315_17385	COG0745	RESPONSE REGULATOR receiver
BI315_17400	COG0277	FAD linked oxidase domain protein
BI315_17405	COG1988	membrane-bound metal-dependent
BI315_17410	COG0792	nuclease activity
BI315_17440	COG2001	Belongs to the MraZ family
BI315_17445	COG0275	rRNA processing
BI315_17450	COG3116	cell division
BI315_17460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BI315_17465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BI315_17470	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BI315_17480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BI315_17485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BI315_17490	COG1181	Belongs to the D-alanine--D-alanine ligase family
BI315_17495	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BI315_17510	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BI315_17520	COG0739	heme binding
BI315_17525	COG0653	protein targeting
BI315_17530	COG0494	nUDIX hydrolase
BI315_17540	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BI315_17555	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_17555	COG3321	synthase
BI315_17555	COG0604	alcohol dehydrogenase
BI315_17585	COG0366	Alpha amylase catalytic
BI315_17620	COG2226	methyltransferase
BI315_17625	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BI315_17640	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BI315_17685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BI315_17695	COG4106	trans-aconitate 2-methyltransferase activity
BI315_17700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BI315_17710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI315_17715	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BI315_17725	COG0667	Aldo Keto reductase
BI315_17735	COG4771	TonB-dependent receptor
BI315_17755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI315_17760	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BI315_17770	COG2175	clavaminate synthase activity
BI315_17780	COG4181	ATPase activity
BI315_17795	COG0642	Histidine kinase
BI315_17810	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BI315_17830	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BI315_17835	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BI315_17850	COG3829	transcription factor binding
BI315_17860	COG1116	anion transmembrane transporter activity
BI315_17865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI315_17875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI315_17880	COG0431	NADPH-dependent FMN reductase
BI315_17905	COG0747	negative chemotaxis
BI315_17925	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BI315_17930	COG2967	ApaG domain
BI315_17935	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BI315_17940	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BI315_17945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI315_17950	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BI315_17965	COG0123	including yeast histone deacetylase and acetoin utilization protein
BI315_17970	COG2096	Adenosyltransferase
BI315_17985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI315_17990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI315_18020	COG3384	dioxygenase
BI315_18025	COG0583	DNA-binding transcription factor activity
BI315_18040	COG1024	Enoyl-CoA hydratase
BI315_18060	COG3386	PFAM SMP-30 Gluconolaconase
BI315_18075	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BI315_18100	COG0697	spore germination
BI315_18110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI315_18125	COG3706	GGDEF domain
BI315_18125	COG0745	RESPONSE REGULATOR receiver
BI315_18130	COG0784	Response regulator, receiver
BI315_18130	COG5002	protein histidine kinase activity
BI315_18130	COG2205	protein histidine kinase activity
BI315_18135	COG2197	response regulator
BI315_18145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BI315_18155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BI315_18160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI315_18170	COG0583	DNA-binding transcription factor activity
BI315_18175	COG3634	alkyl hydroperoxide reductase activity
BI315_18185	COG2890	protein-(glutamine-N5) methyltransferase activity
BI315_18205	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI315_18205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI315_18235	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BI315_18260	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BI315_18265	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BI315_18280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BI315_18285	COG1404	Belongs to the peptidase S8 family
BI315_18290	COG1404	Belongs to the peptidase S8 family
BI315_18295	COG1404	Belongs to the peptidase S8 family
BI315_18300	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BI315_18325	COG1295	ribonuclease BN
BI315_18330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI315_18350	COG0521	Mo-molybdopterin cofactor biosynthetic process
BI315_18360	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BI315_18375	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BI315_18380	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BI315_18390	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BI315_18395	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BI315_18400	COG0193	aminoacyl-tRNA hydrolase activity
BI315_18405	COG0012	GTP binding
BI315_18425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BI315_18435	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BI315_18440	COG0250	Participates in transcription elongation, termination and antitermination
BI315_18445	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BI315_18450	COG0081	regulation of translation
BI315_18455	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BI315_18460	COG0222	ribosome binding
BI315_18465	COG0085	RNA polymerase activity
BI315_18470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BI315_18475	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BI315_18480	COG0049	tRNA binding
BI315_18485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BI315_18490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BI315_18495	COG0051	transcription antitermination factor activity, RNA binding
BI315_18500	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BI315_18505	COG0088	Forms part of the polypeptide exit tunnel
BI315_18510	COG0089	rRNA binding
BI315_18515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BI315_18520	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BI315_18525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BI315_18530	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BI315_18535	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BI315_18540	COG0255	Belongs to the universal ribosomal protein uL29 family
BI315_18545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BI315_18550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BI315_18555	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BI315_18560	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BI315_18565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BI315_18570	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BI315_18575	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BI315_18580	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BI315_18585	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BI315_18590	COG1841	ribosomal large subunit assembly
BI315_18595	COG0200	Binds to the 23S rRNA
BI315_18600	COG0201	protein transport
BI315_18605	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BI315_18610	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BI315_18615	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BI315_18620	COG0202	RNA polymerase activity
BI315_18625	COG0203	ribosomal protein L17
BI315_18630	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BI315_18650	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BI315_18660	COG0154	amidase activity
BI315_18675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BI315_18680	COG0039	L-malate dehydrogenase activity
BI315_18685	COG0625	glutathione transferase activity
BI315_18700	COG1902	pentaerythritol trinitrate reductase activity
BI315_18700	COG0446	pyridine nucleotide-disulphide oxidoreductase
BI315_18705	COG0604	alcohol dehydrogenase
BI315_18735	COG0156	8-amino-7-oxononanoate synthase activity
BI315_18740	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BI315_18745	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BI315_18750	COG4208	sulfate ABC transporter
BI315_18755	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BI315_18765	COG1063	alcohol dehydrogenase
BI315_18795	COG0406	alpha-ribazole phosphatase activity
BI315_18800	COG0285	dihydrofolate synthase activity
BI315_18820	COG2833	Protein of unknown function (DUF455)
BI315_18830	COG3291	Pkd domain containing protein
BI315_18840	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI315_18845	COG0671	phosphoesterase, PA-phosphatase related
BI315_18850	COG0438	transferase activity, transferring glycosyl groups
BI315_18860	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BI315_18875	COG4783	chaperone-mediated protein folding
BI315_18890	COG0473	3-isopropylmalate dehydrogenase activity
BI315_18920	COG2801	Transposase and inactivated derivatives
BI315_19025	COG2801	Transposase and inactivated derivatives
BI315_19050	COG0544	peptidyl-prolyl cis-trans isomerase activity
BI315_19055	COG0740	serine-type endopeptidase activity
BI315_19060	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BI315_19085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI315_19095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI315_19105	COG0328	RNA-DNA hybrid ribonuclease activity
BI315_19110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BI315_19115	COG0631	protein serine/threonine phosphatase activity
BI315_19130	COG0859	PFAM glycosyl transferase family 9
BI315_19135	COG3642	lipopolysaccharide core region biosynthetic process
BI315_19140	COG1234	tRNA 3'-trailer cleavage
BI315_19145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BI315_19155	COG0315	cyclic pyranopterin monophosphate synthase activity
BI315_19160	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BI315_19165	COG0314	molybdopterin synthase activity
BI315_19230	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BI315_19235	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BI315_19240	COG0537	adenosine 5'-monophosphoramidase activity
BI315_19260	COG0714	Associated with various cellular activities
BI315_19285	COG0424	maF-like protein
BI315_19290	COG1399	metal-binding, possibly nucleic acid-binding protein
BI315_19295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BI315_19300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI315_19315	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_19320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BI315_19330	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BI315_19335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BI315_19360	COG3829	transcription factor binding
BI315_19380	COG3609	addiction module antidote protein, CC2985 family
BI315_19410	COG2373	Large extracellular alpha-helical protein
BI315_19430	COG4953	penicillin-binding protein 1C
BI315_19440	COG0678	peroxiredoxin activity
BI315_19460	COG0330	HflC and HflK could
BI315_19465	COG0330	HflC and HflK could
BI315_19480	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BI315_19485	COG0308	aminopeptidase N
BI315_19490	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_19495	COG1309	transcriptional regulator
BI315_19540	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BI315_19570	COG0406	alpha-ribazole phosphatase activity
BI315_19570	COG0328	RNA-DNA hybrid ribonuclease activity
BI315_19575	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BI315_19585	COG3387	PFAM Glycoside hydrolase 15-related
BI315_19590	COG1028	Short-chain dehydrogenase reductase Sdr
BI315_19600	COG3537	Alpha-1,2-mannosidase
BI315_19620	COG0492	ferredoxin-NADP+ reductase activity
BI315_19645	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI315_19650	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BI315_19655	COG2080	2 iron, 2 sulfur cluster binding
BI315_19690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BI315_19705	COG0587	DNA-directed DNA polymerase activity
BI315_19725	COG1297	OPT oligopeptide transporter protein
BI315_19740	COG0823	Involved in the tonB-independent uptake of proteins
BI315_19740	COG1506	peptidase
BI315_19760	COG2207	Transcriptional regulator
BI315_19760	COG1917	Cupin 2, conserved barrel domain protein
BI315_19775	COG0753	catalase activity
BI315_19780	COG0656	L-ascorbic acid biosynthetic process
BI315_19790	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BI315_19790	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BI315_19795	COG2814	Major facilitator Superfamily
BI315_19810	COG2194	sulfuric ester hydrolase activity
BI315_19825	COG0745	RESPONSE REGULATOR receiver
BI315_19830	COG0642	Histidine kinase
BI315_19840	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BI315_19845	COG2894	cell division
BI315_19850	COG0850	regulation of cytokinetic process
BI315_19865	COG4585	Histidine kinase
BI315_19870	COG2197	response regulator
BI315_19885	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BI315_19915	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BI315_19925	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BI315_19945	COG1946	Acyl-CoA thioesterase
BI315_19960	COG0824	Thioesterase
BI315_19965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BI315_19970	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BI315_19975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BI315_19980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BI315_19985	COG0268	Binds directly to 16S ribosomal RNA
BI315_19995	COG0196	riboflavin kinase activity
BI315_20000	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BI315_20005	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BI315_20010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BI315_20025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BI315_20030	COG1845	cytochrome c oxidase, subunit III
BI315_20035	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BI315_20050	COG3152	Membrane
BI315_20060	COG2207	Transcriptional regulator
BI315_20065	COG0326	Molecular chaperone. Has ATPase activity
BI315_20080	COG1366	Belongs to the anti-sigma-factor antagonist family
BI315_20085	COG1366	Belongs to the anti-sigma-factor antagonist family
BI315_20090	COG2172	sigma factor antagonist activity
BI315_20115	COG4771	TonB-dependent receptor
BI315_20125	COG5507	3-demethylubiquinone-9 3-methyltransferase
BI315_20130	COG2205	protein histidine kinase activity
BI315_20140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BI315_20145	COG4999	Histidine kinase
BI315_20145	COG2205	protein histidine kinase activity
BI315_20145	COG3850	Histidine kinase
BI315_20145	COG3437	response regulator, receiver
BI315_20150	COG4191	Histidine kinase
BI315_20150	COG0784	Response regulator, receiver
BI315_20175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BI315_20180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BI315_20190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BI315_20195	COG0228	four-way junction DNA binding
BI315_20200	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BI315_20205	COG0336	Belongs to the RNA methyltransferase TrmD family
BI315_20210	COG0335	large ribosomal subunit rRNA binding
BI315_20235	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BI315_20245	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BI315_20265	COG3209	COG3209 Rhs family protein
BI315_20290	COG3250	beta-galactosidase activity
BI315_20295	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BI315_20315	COG1960	acyl-CoA dehydrogenase activity
BI315_20320	COG1024	Enoyl-CoA hydratase
BI315_20340	COG1024	Enoyl-CoA hydratase
BI315_20340	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI315_20355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI315_20360	COG0481	GTPase activity
BI315_20375	COG0571	ribonuclease III activity
BI315_20380	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BI315_20385	COG1381	Involved in DNA repair and RecF pathway recombination
BI315_20395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BI315_20405	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BI315_20410	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BI315_20415	COG3046	protein related to deoxyribodipyrimidine photolyase
BI315_20420	COG1472	Belongs to the glycosyl hydrolase 3 family
BI315_20430	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BI315_20435	COG1278	Cold shock
BI315_20440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI315_20450	COG1201	RNA secondary structure unwinding
BI315_20455	COG1793	dna ligase
BI315_20465	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BI315_20465	COG1793	dna ligase
BI315_20480	COG0745	RESPONSE REGULATOR receiver
BI315_20480	COG3706	GGDEF domain
BI315_20500	COG0183	Belongs to the thiolase family
BI315_20525	COG1451	nucleotide metabolic process
BI315_20530	COG5487	UPF0391 membrane protein
BI315_20540	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BI315_20555	COG1077	Cell shape determining protein MreB Mrl
BI315_20560	COG1047	Peptidyl-prolyl cis-trans
BI315_20570	COG2824	Alkylphosphonate utilization operon protein PhnA
BI315_20580	COG1902	pentaerythritol trinitrate reductase activity
BI315_20585	COG2814	Major facilitator Superfamily
BI315_20620	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BI315_20620	COG0392	lysyltransferase activity
BI315_20630	COG0251	oxidation-reduction process
BI315_20635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BI315_20650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BI315_20675	COG1595	DNA-templated transcription, initiation
BI315_20695	COG2878	Part of a membrane complex involved in electron transport
BI315_20705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI315_20705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI315_20720	COG1131	(ABC) transporter
BI315_20725	COG0346	lactoylglutathione lyase activity
BI315_20730	COG0833	amino acid
BI315_20735	COG2040	homocysteine
BI315_20745	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BI315_20765	COG1695	Transcriptional regulator
BI315_20800	COG0825	malonyl-CoA metabolic process
BI315_20810	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BI315_20815	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI315_20820	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI315_20825	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI315_20830	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI315_20845	COG0750	zinc metalloprotease
BI315_20850	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BI315_20855	COG0575	Belongs to the CDS family
BI315_20860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BI315_20865	COG0233	cytoplasmic translational termination
BI315_20870	COG0528	UMP kinase activity
BI315_20875	COG3706	GGDEF domain
BI315_20875	COG0745	RESPONSE REGULATOR receiver
BI315_20880	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BI315_20885	COG0052	Belongs to the universal ribosomal protein uS2 family
BI315_20920	COG0024	Methionine aminopeptidase
BI315_20925	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BI315_20935	COG1393	Belongs to the ArsC family
BI315_20940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI315_20945	COG0367	asparagine synthase
BI315_20955	COG4774	siderophore transport
BI315_20975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BI315_21005	COG1566	PFAM secretion protein HlyD family protein
BI315_21010	COG2814	Major facilitator Superfamily
BI315_21030	COG3104	oligopeptide transport
BI315_21060	COG0339	signal peptide processing
BI315_21070	COG0386	Belongs to the glutathione peroxidase family
BI315_21125	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BI315_21145	COG1960	acyl-CoA dehydrogenase activity
BI315_21165	COG0367	asparagine synthase
BI315_21175	COG0305	Participates in initiation and elongation during chromosome replication
BI315_21180	COG0415	Belongs to the DNA photolyase family
BI315_21205	COG0583	DNA-binding transcription factor activity
BI315_21240	COG3706	GGDEF domain
BI315_21250	COG3706	GGDEF domain
BI315_21375	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BI315_21390	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI315_21400	COG0497	DNA recombination
BI315_21405	COG1420	regulation of RNA biosynthetic process
BI315_21410	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BI315_21415	COG0443	Heat shock 70 kDa protein
BI315_21420	COG0484	heat shock protein binding
BI315_21430	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BI315_21460	COG0583	DNA-binding transcription factor activity
BI315_21465	COG1132	(ABC) transporter
BI315_21500	COG2850	peptidyl-arginine hydroxylation
BI315_21520	COG1253	flavin adenine dinucleotide binding
BI315_21550	COG1131	(ABC) transporter
BI315_21555	COG1725	Transcriptional regulator
BI315_21565	COG0386	Belongs to the glutathione peroxidase family
BI315_21580	COG2900	Belongs to the SlyX family
BI315_21605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI315_21615	COG0646	methionine synthase
BI315_21615	COG1410	methionine synthase
BI315_21620	COG1410	methionine synthase
BI315_21620	COG0646	methionine synthase
BI315_21630	COG1960	acyl-CoA dehydrogenase activity
BI315_21635	COG1960	acyl-CoA dehydrogenase activity
BI315_21640	COG1960	acyl-CoA dehydrogenase activity
BI315_21645	COG1960	acyl-CoA dehydrogenase activity
BI315_21665	COG0557	exoribonuclease II activity
BI315_21675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI315_21680	COG3706	GGDEF domain
BI315_21685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BI315_21695	COG0704	Plays a role in the regulation of phosphate uptake
BI315_21700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BI315_21705	COG0581	inorganic phosphate transmembrane transporter activity
BI315_21710	COG0573	inorganic phosphate transmembrane transporter activity
BI315_21715	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BI315_21740	COG0659	secondary active sulfate transmembrane transporter activity
BI315_21745	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BI315_21755	COG1024	Enoyl-CoA hydratase
BI315_21765	COG0494	nUDIX hydrolase
BI315_21810	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BI315_21810	COG0116	Belongs to the methyltransferase superfamily
BI315_21815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BI315_21840	COG2925	Exonuclease
BI315_21850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI315_21855	COG3844	kynureninase activity
BI315_21865	COG0662	Cupin 2, conserved barrel domain protein
BI315_21870	COG0288	reversible hydration of carbon dioxide
BI315_21935	COG2808	Putative FMN-binding domain
BI315_21955	COG0017	Asparaginyl-tRNA synthetase
BI315_21965	COG0316	Belongs to the HesB IscA family
BI315_21970	COG0360	Binds together with S18 to 16S ribosomal RNA
BI315_21975	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BI315_21980	COG0359	binds to the 23S rRNA
BI315_21990	COG3115	cell septum assembly
BI315_22000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI315_22005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BI315_22010	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BI315_22025	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BI315_22035	COG4993	Dehydrogenase
BI315_22045	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BI315_22055	COG2986	histidine ammonia-lyase
BI315_22060	COG1228	amidohydrolase
BI315_22105	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BI315_22110	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BI315_22115	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BI315_22120	COG0077	Prephenate dehydratase
BI315_22120	COG1605	Chorismate mutase
BI315_22125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BI315_22140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BI315_22145	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BI315_22150	COG0583	DNA-binding transcription factor activity
BI315_22210	COG0840	transmembrane signaling receptor activity
BI315_22245	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BI315_22250	COG4191	Histidine kinase
BI315_22250	COG0784	Response regulator, receiver
BI315_22265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI315_22275	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BI315_22285	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BI315_22300	COG1595	DNA-templated transcription, initiation
BI315_22355	COG2244	polysaccharide biosynthetic process
BI315_22390	COG2264	protein methyltransferase activity
BI315_22400	COG0438	transferase activity, transferring glycosyl groups
BI315_22415	COG1136	(ABC) transporter
BI315_22425	COG0477	Major facilitator Superfamily
BI315_22430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI315_22445	COG1253	flavin adenine dinucleotide binding
BI315_22460	COG0306	phosphate transporter
BI315_22485	COG0504	CTP synthase activity
BI315_22490	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BI315_22500	COG0148	phosphopyruvate hydratase activity
BI315_22505	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BI315_22510	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BI315_22515	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BI315_22520	COG0585	pseudouridine synthase activity
BI315_22525	COG2840	Smr protein MutS2
BI315_22530	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BI315_22535	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BI315_22540	COG1238	metal cluster binding
BI315_22555	COG1534	Rna-binding protein
BI315_22560	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BI315_22565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BI315_22570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BI315_22575	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BI315_22580	COG1923	regulation of RNA biosynthetic process
BI315_22585	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BI315_22590	COG1546	Belongs to the CinA family
BI315_22600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BI315_22605	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BI315_22615	COG2137	regulation of response to DNA damage stimulus
BI315_22620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BI315_22625	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BI315_22645	COG1741	Belongs to the pirin family
BI315_22650	COG0583	DNA-binding transcription factor activity
BI315_22675	COG0352	thiamine-phosphate diphosphorylase activity
BI315_22675	COG0351	phosphomethylpyrimidine kinase
BI315_22690	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BI315_22695	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BI315_22710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI315_22720	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BI315_22725	COG3734	2-keto-3-deoxy-galactonokinase
BI315_22735	COG4948	Mandelate Racemase Muconate Lactonizing
BI315_22740	COG0800	Aldolase
BI315_22780	COG1501	Belongs to the glycosyl hydrolase 31 family
BI315_22790	COG1070	Carbohydrate kinase
BI315_22795	COG2115	Belongs to the xylose isomerase family
BI315_22800	COG0477	Major facilitator Superfamily
BI315_22820	COG0860	N-Acetylmuramoyl-L-alanine amidase
BI315_22825	COG1469	GTP cyclohydrolase I activity
BI315_22845	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BI315_22850	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BI315_22855	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BI315_22860	COG0166	Belongs to the GPI family
BI315_22885	COG1472	Belongs to the glycosyl hydrolase 3 family
BI315_22900	COG5001	Diguanylate cyclase
BI315_22900	COG3706	GGDEF domain
BI315_22900	COG2203	Gaf domain
BI315_22900	COG4251	negative regulation of phosphorylation
BI315_22910	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI315_22915	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BI315_22930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BI315_22935	COG0671	phosphoesterase, PA-phosphatase related
BI315_22950	COG1794	racemase activity, acting on amino acids and derivatives
BI315_22955	COG0697	spore germination
BI315_22960	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BI315_22965	COG0167	dihydroorotate dehydrogenase activity
BI315_22985	COG1012	belongs to the aldehyde dehydrogenase family
BI315_23000	COG1215	transferase activity, transferring glycosyl groups
BI315_23005	COG0726	polysaccharide deacetylase
BI315_23005	COG1649	PFAM Uncharacterised BCR, COG1649
BI315_23020	COG3210	domain, Protein
BI315_23030	COG3210	domain, Protein
BI315_23075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI315_23080	COG0124	histidyl-tRNA synthetase
BI315_23090	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BI315_23095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BI315_23100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI315_23105	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BI315_23105	COG0131	Imidazoleglycerol-phosphate dehydratase
BI315_23110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BI315_23115	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BI315_23120	COG0107	imidazoleglycerol-phosphate synthase activity
BI315_23125	COG0140	phosphoribosyl-ATP diphosphatase activity
BI315_23125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BI315_23140	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BI315_23145	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BI315_23150	COG0235	Class ii aldolase
BI315_23155	COG0531	amino acid
BI315_23160	COG0531	amino acid
BI315_23170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BI315_23175	COG0277	FAD linked oxidase domain protein
BI315_23195	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BI315_23240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI315_23245	COG2258	MOSC domain
BI315_23250	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BI315_23255	COG0505	Belongs to the CarA family
BI315_23265	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BI315_23270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI315_23280	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BI315_23300	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BI315_23325	COG0653	protein targeting
BI315_23355	COG2132	Multicopper oxidase
BI315_23410	COG0010	Belongs to the arginase family
BI315_23425	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI315_23430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI315_23520	COG4232	protein-disulfide reductase activity
BI315_23620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BI315_23645	COG0629	single-stranded DNA binding
BI315_23680	COG1475	DNA binding
BI315_23710	COG2963	transposase activity
BI315_23715	COG2801	Transposase and inactivated derivatives
BI315_23750	COG1525	nuclease
BI315_23830	COG0745	RESPONSE REGULATOR receiver
BI315_23840	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BI315_23850	COG1199	ATP-dependent helicase activity
BI315_24295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BI315_24320	COG4644	lycopene metabolic process
BI315_24365	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BI315_24370	COG0431	NADPH-dependent FMN reductase
BI315_24440	COG2948	multi-organism process
BI315_24445	COG3504	Conjugal transfer protein
BI315_24555	COG4456	Virulence-associated protein
BI315_24560	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BI315_24565	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BI315_24600	COG3318	Belongs to the UPF0149 family
BI315_24600	COG3012	SEC-C Motif Domain Protein
BI315_24660	COG3318	Belongs to the UPF0149 family
BI315_24660	COG3012	SEC-C Motif Domain Protein
BI315_24680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BI315_24725	COG2951	lytic endotransglycosylase activity
BI315_24730	COG4644	lycopene metabolic process
BI315_24840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BI315_24870	COG1192	Involved in chromosome partitioning
BI315_25025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BI315_25090	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BI315_25110	COG3318	Belongs to the UPF0149 family
BI315_25110	COG3012	SEC-C Motif Domain Protein
BI315_25200	COG1475	DNA binding
BI315_25220	COG2885	chlorophyll binding