locus-tag	class	description
J163_00006	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J163_00037	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J163_00042	COG1192	Involved in chromosome partitioning
J163_00050	COG2951	lytic endotransglycosylase activity
J163_00051	COG4644	lycopene metabolic process
J163_00079	COG2948	multi-organism process
J163_00080	COG3504	Conjugal transfer protein
J163_00101	COG4456	Virulence-associated protein
J163_00102	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J163_00104	COG2801	Transposase and inactivated derivatives
J163_00109	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J163_00110	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J163_00112	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J163_00114	COG0187	DNA topoisomerase II activity
J163_00116	COG0501	Belongs to the peptidase M48B family
J163_00122	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
J163_00124	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J163_00133	COG0793	Belongs to the peptidase S41A family
J163_00134	COG4942	peptidase
J163_00136	COG2234	aminopeptidase activity
J163_00138	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J163_00139	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J163_00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J163_00141	COG1064	alcohol dehydrogenase
J163_00142	COG0493	'glutamate synthase
J163_00143	COG0067	glutamate synthase
J163_00143	COG0069	glutamate synthase activity
J163_00143	COG0070	glutamate synthase
J163_00147	COG2366	antibiotic biosynthetic process
J163_00152	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J163_00155	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
J163_00156	COG0297	glycogen (starch) synthase activity
J163_00156	COG0438	transferase activity, transferring glycosyl groups
J163_00160	COG0367	asparagine synthase
J163_00166	COG1132	(ABC) transporter
J163_00190	COG1111	helicase
J163_00190	COG1205	dead DEAH box helicase
J163_00191	COG1272	protein, Hemolysin III
J163_00194	COG0300	oxidoreductase activity
J163_00195	COG1028	Short-chain dehydrogenase reductase Sdr
J163_00200	COG2249	NAD(P)H dehydrogenase (quinone) activity
J163_00202	COG2963	transposase activity
J163_00203	COG2801	Transposase and inactivated derivatives
J163_00211	COG3237	CsbD-like
J163_00220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J163_00221	COG0477	Major facilitator Superfamily
J163_00229	COG0714	Associated with various cellular activities
J163_00235	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
J163_00237	COG4772	TonB-dependent receptor
J163_00239	COG0662	Cupin 2, conserved barrel domain protein
J163_00240	COG1012	belongs to the aldehyde dehydrogenase family
J163_00245	COG1304	FMN binding
J163_00247	COG4585	Histidine kinase
J163_00248	COG2197	response regulator
J163_00252	COG3710	Transcriptional regulator
J163_00253	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J163_00266	COG2963	transposase activity
J163_00268	COG0366	Alpha amylase catalytic
J163_00269	COG0366	Alpha amylase catalytic
J163_00270	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J163_00274	COG2755	lipolytic protein G-D-S-L family
J163_00274	COG0657	acetylesterase activity
J163_00276	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J163_00279	COG3507	Belongs to the glycosyl hydrolase 43 family
J163_00280	COG1609	Transcriptional regulator
J163_00281	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
J163_00282	COG1028	Short-chain dehydrogenase reductase Sdr
J163_00284	COG2755	lipolytic protein G-D-S-L family
J163_00287	COG3186	Phenylalanine-4-hydroxylase
J163_00288	COG1522	sequence-specific DNA binding
J163_00290	COG1752	Esterase of the alpha-beta hydrolase superfamily
J163_00292	COG1119	ATPase activity
J163_00295	COG1125	glycine betaine transport
J163_00298	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J163_00301	COG1396	sequence-specific DNA binding
J163_00305	COG0489	protein tyrosine kinase activity
J163_00306	COG2062	phosphohistidine phosphatase, SixA
J163_00308	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J163_00317	COG1968	undecaprenyl-diphosphatase activity
J163_00318	COG0174	glutamine synthetase
J163_00319	COG0347	Belongs to the P(II) protein family
J163_00320	COG0004	ammonium transporteR
J163_00321	COG3852	Histidine kinase
J163_00322	COG2204	response regulator
J163_00323	COG2032	superoxide dismutase activity
J163_00324	COG2032	superoxide dismutase activity
J163_00325	COG0346	lactoylglutathione lyase activity
J163_00327	COG0183	Belongs to the thiolase family
J163_00334	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J163_00335	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
J163_00336	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J163_00338	COG0028	Belongs to the TPP enzyme family
J163_00339	COG2205	protein histidine kinase activity
J163_00344	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J163_00347	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J163_00349	COG0596	Alpha beta hydrolase
J163_00351	COG0318	PFAM AMP-dependent synthetase and ligase
J163_00353	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J163_00355	COG1181	Belongs to the D-alanine--D-alanine ligase family
J163_00357	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J163_00359	COG0564	pseudouridine synthase activity
J163_00364	COG0339	signal peptide processing
J163_00369	COG0475	glutathione-regulated potassium exporter activity
J163_00370	COG0583	DNA-binding transcription factor activity
J163_00371	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J163_00372	COG2224	Isocitrate lyase
J163_00373	COG3706	GGDEF domain
J163_00379	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J163_00380	COG1960	acyl-CoA dehydrogenase activity
J163_00391	COG0523	cobalamin synthesis protein
J163_00393	COG0697	spore germination
J163_00395	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
J163_00396	COG1846	Transcriptional regulator
J163_00397	COG1764	response to oxidative stress
J163_00402	COG2130	NADP-dependent
J163_00405	COG1187	pseudouridine synthase activity
J163_00408	COG1643	Atp-dependent helicase
J163_00409	COG4807	Protein conserved in bacteria
J163_00410	COG2351	hydroxyisourate hydrolase activity
J163_00411	COG2072	flavoprotein involved in K transport
J163_00415	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J163_00422	COG1957	nucleoside hydrolase
J163_00424	COG2252	PERMEase
J163_00428	COG0084	hydrolase, TatD family'
J163_00431	COG0583	DNA-binding transcription factor activity
J163_00432	COG2814	Major facilitator Superfamily
J163_00435	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J163_00436	COG1902	pentaerythritol trinitrate reductase activity
J163_00440	COG0745	RESPONSE REGULATOR receiver
J163_00441	COG2205	protein histidine kinase activity
J163_00442	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J163_00444	COG1538	Outer membrane efflux protein
J163_00446	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J163_00447	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J163_00448	COG0583	DNA-binding transcription factor activity
J163_00454	COG0702	epimerase
J163_00455	COG1733	regulation of RNA biosynthetic process
J163_00460	COG2963	transposase activity
J163_00462	COG0129	dihydroxy-acid dehydratase activity
J163_00465	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
J163_00476	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J163_00477	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J163_00482	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
J163_00483	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
J163_00485	COG3485	protocatechuate 3,4-dioxygenase
J163_00486	COG3485	protocatechuate 3,4-dioxygenase
J163_00488	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J163_00489	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J163_00491	COG1414	Transcriptional regulator
J163_00495	COG0445	tRNA wobble uridine modification
J163_00503	COG2267	carboxylic ester hydrolase activity
J163_00505	COG0156	8-amino-7-oxononanoate synthase activity
J163_00506	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J163_00507	COG1040	competence protein
J163_00508	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J163_00525	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J163_00539	COG3264	Mechanosensitive ion channel
J163_00539	COG1511	domain protein
J163_00540	COG1368	sulfuric ester hydrolase activity
J163_00541	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J163_00542	COG2354	Protein conserved in bacteria
J163_00543	COG3706	GGDEF domain
J163_00543	COG0745	RESPONSE REGULATOR receiver
J163_00544	COG0297	glycogen (starch) synthase activity
J163_00545	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J163_00546	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J163_00551	COG0702	epimerase
J163_00552	COG1028	Short-chain dehydrogenase reductase Sdr
J163_00558	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J163_00559	COG1028	Short-chain dehydrogenase reductase Sdr
J163_00561	COG0513	Belongs to the DEAD box helicase family
J163_00566	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J163_00568	COG3483	tryptophan 2,3-dioxygenase activity
J163_00569	COG3104	oligopeptide transport
J163_00573	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
J163_00576	COG1320	monovalent cation:proton antiporter activity
J163_00577	COG2212	antiporter activity
J163_00579	COG0651	ATP synthesis coupled electron transport
J163_00580	COG1006	Multisubunit Na H antiporter MnhC subunit
J163_00581	COG2111	Na H antiporter
J163_00581	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J163_00585	COG3179	chitinase
J163_00589	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J163_00590	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
J163_00593	COG0456	acetyltransferase
J163_00594	COG1597	lipid kinase activity
J163_00599	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J163_00600	COG0134	indole-3-glycerol-phosphate synthase activity
J163_00602	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J163_00603	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
J163_00605	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
J163_00606	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J163_00607	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J163_00610	COG1051	belongs to the nudix hydrolase family
J163_00617	COG0316	Belongs to the HesB IscA family
J163_00621	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
J163_00624	COG2814	Major facilitator Superfamily
J163_00625	COG0583	DNA-binding transcription factor activity
J163_00626	COG2814	Major facilitator Superfamily
J163_00627	COG1289	transmembrane transporter activity
J163_00628	COG0151	Belongs to the GarS family
J163_00630	COG0138	bifunctional purine biosynthesis protein purh
J163_00631	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J163_00632	COG2267	carboxylic ester hydrolase activity
J163_00633	COG2453	phosphatase
J163_00633	COG0671	phosphoesterase, PA-phosphatase related
J163_00638	COG4589	Belongs to the CDS family
J163_00639	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
J163_00644	COG2264	protein methyltransferase activity
J163_00647	COG0439	Biotin carboxylase
J163_00649	COG0511	ligase activity, forming carbon-carbon bonds
J163_00650	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
J163_00652	COG1324	tolerance protein
J163_00657	COG0300	oxidoreductase activity
J163_00658	COG2356	endonuclease I
J163_00659	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J163_00660	COG0459	protein refolding
J163_00663	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J163_00666	COG3386	PFAM SMP-30 Gluconolaconase
J163_00668	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
J163_00669	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J163_00672	COG0778	Nitroreductase
J163_00673	COG2353	YceI-like domain
J163_00678	COG3052	prosthetic group binding
J163_00682	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
J163_00684	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J163_00686	COG1802	Transcriptional regulator
J163_00696	COG2963	transposase activity
J163_00697	COG4221	oxidoreductase activity
J163_00700	COG4221	oxidoreductase activity
J163_00702	COG0435	Glutathione S-transferase
J163_00707	COG2409	Drug exporters of the RND superfamily
J163_00708	COG0823	Involved in the tonB-independent uptake of proteins
J163_00708	COG1506	peptidase
J163_00710	COG3706	GGDEF domain
J163_00714	COG0697	spore germination
J163_00718	COG1113	amino acid transport
J163_00720	COG0598	Magnesium transport protein CorA
J163_00722	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
J163_00729	COG5001	Diguanylate cyclase
J163_00730	COG0840	transmembrane signaling receptor activity
J163_00731	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J163_00731	COG5297	Belongs to the glycosyl hydrolase family 6
J163_00732	COG0659	secondary active sulfate transmembrane transporter activity
J163_00733	COG3706	GGDEF domain
J163_00736	COG2943	transferase activity, transferring hexosyl groups
J163_00738	COG3275	phosphorelay sensor kinase activity
J163_00740	COG0181	hydroxymethylbilane synthase activity
J163_00745	COG1505	serine-type exopeptidase activity
J163_00746	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J163_00749	COG2832	Protein of unknown function (DUF454)
J163_00751	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J163_00753	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
J163_00754	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
J163_00755	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
J163_00760	COG2226	methyltransferase
J163_00761	COG5001	Diguanylate cyclase
J163_00761	COG3300	MHYT domain
J163_00762	COG0308	aminopeptidase N
J163_00771	COG3284	Transcriptional regulator
J163_00773	COG1077	Cell shape determining protein MreB Mrl
J163_00774	COG1792	Involved in formation and maintenance of cell shape
J163_00777	COG0772	Belongs to the SEDS family
J163_00779	COG2951	lytic endotransglycosylase activity
J163_00780	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J163_00781	COG1686	Belongs to the peptidase S11 family
J163_00783	COG2921	Belongs to the UPF0250 family
J163_00784	COG0321	lipoyl(octanoyl) transferase activity
J163_00785	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J163_00788	COG0583	DNA-binding transcription factor activity
J163_00790	COG1051	belongs to the nudix hydrolase family
J163_00790	COG1056	cytidyltransferase-related domain
J163_00797	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
J163_00798	COG0673	inositol 2-dehydrogenase activity
J163_00799	COG2823	Periplasmic or secreted lipoprotein
J163_00800	COG4251	negative regulation of phosphorylation
J163_00801	COG0784	Response regulator, receiver
J163_00802	COG4191	Histidine kinase
J163_00803	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J163_00804	COG1028	Short-chain dehydrogenase reductase Sdr
J163_00814	COG1459	type II secretion system
J163_00825	COG3250	beta-galactosidase activity
J163_00831	COG1609	Transcriptional regulator
J163_00832	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J163_00833	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J163_00835	COG0617	tRNA 3'-terminal CCA addition
J163_00836	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
J163_00837	COG1012	belongs to the aldehyde dehydrogenase family
J163_00838	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J163_00840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J163_00844	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J163_00845	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J163_00848	COG2205	protein histidine kinase activity
J163_00849	COG0745	RESPONSE REGULATOR receiver
J163_00854	COG3791	Glutathione-dependent formaldehyde-activating
J163_00856	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J163_00858	COG0697	spore germination
J163_00860	COG0488	(ABC) transporter
J163_00862	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J163_00863	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J163_00865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J163_00865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J163_00870	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J163_00871	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J163_00872	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
J163_00876	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
J163_00877	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
J163_00878	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
J163_00879	COG2205	protein histidine kinase activity
J163_00880	COG0745	RESPONSE REGULATOR receiver
J163_00883	COG0277	FAD linked oxidase domain protein
J163_00884	COG1988	membrane-bound metal-dependent
J163_00885	COG0792	nuclease activity
J163_00892	COG2001	Belongs to the MraZ family
J163_00893	COG0275	rRNA processing
J163_00894	COG3116	cell division
J163_00896	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J163_00897	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J163_00898	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J163_00900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J163_00901	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J163_00902	COG1181	Belongs to the D-alanine--D-alanine ligase family
J163_00903	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J163_00906	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
J163_00908	COG0739	heme binding
J163_00909	COG0653	protein targeting
J163_00910	COG0494	nUDIX hydrolase
J163_00912	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J163_00915	COG0604	alcohol dehydrogenase
J163_00915	COG1028	Short-chain dehydrogenase reductase Sdr
J163_00915	COG3321	synthase
J163_00919	COG0366	Alpha amylase catalytic
J163_00925	COG2226	methyltransferase
J163_00926	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J163_00929	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
J163_00935	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J163_00937	COG4106	trans-aconitate 2-methyltransferase activity
J163_00938	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J163_00941	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J163_00942	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
J163_00943	COG0667	Aldo Keto reductase
J163_00945	COG4771	TonB-dependent receptor
J163_00950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J163_00951	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
J163_00953	COG2175	clavaminate synthase activity
J163_00955	COG4181	ATPase activity
J163_00958	COG0642	Histidine kinase
J163_00960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J163_00964	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J163_00965	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J163_00968	COG3829	transcription factor binding
J163_00970	COG1116	anion transmembrane transporter activity
J163_00971	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J163_00973	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J163_00974	COG0431	NADPH-dependent FMN reductase
J163_00979	COG0747	negative chemotaxis
J163_00984	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J163_00985	COG2967	ApaG domain
J163_00986	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J163_00987	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
J163_00988	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J163_00989	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
J163_00992	COG0123	including yeast histone deacetylase and acetoin utilization protein
J163_00993	COG2096	Adenosyltransferase
J163_00995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J163_00996	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J163_01002	COG3384	dioxygenase
J163_01003	COG0583	DNA-binding transcription factor activity
J163_01006	COG1024	Enoyl-CoA hydratase
J163_01010	COG3386	PFAM SMP-30 Gluconolaconase
J163_01012	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
J163_01015	COG0697	spore germination
J163_01016	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J163_01019	COG0745	RESPONSE REGULATOR receiver
J163_01019	COG3706	GGDEF domain
J163_01020	COG0784	Response regulator, receiver
J163_01020	COG2205	protein histidine kinase activity
J163_01020	COG5002	protein histidine kinase activity
J163_01021	COG2197	response regulator
J163_01023	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J163_01025	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J163_01026	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J163_01027	COG0583	DNA-binding transcription factor activity
J163_01028	COG3634	alkyl hydroperoxide reductase activity
J163_01030	COG2890	protein-(glutamine-N5) methyltransferase activity
J163_01034	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J163_01034	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J163_01040	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J163_01045	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J163_01046	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
J163_01049	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J163_01050	COG1404	Belongs to the peptidase S8 family
J163_01051	COG1404	Belongs to the peptidase S8 family
J163_01052	COG1404	Belongs to the peptidase S8 family
J163_01053	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J163_01059	COG1295	ribonuclease BN
J163_01060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J163_01061	COG1254	Belongs to the acylphosphatase family
J163_01064	COG0521	Mo-molybdopterin cofactor biosynthetic process
J163_01066	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J163_01067	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
J163_01069	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
J163_01070	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J163_01072	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J163_01073	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J163_01074	COG0193	aminoacyl-tRNA hydrolase activity
J163_01075	COG0012	GTP binding
J163_01079	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J163_01081	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J163_01082	COG0250	Participates in transcription elongation, termination and antitermination
J163_01083	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J163_01084	COG0081	regulation of translation
J163_01085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J163_01086	COG0222	ribosome binding
J163_01088	COG0085	RNA polymerase activity
J163_01089	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J163_01090	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J163_01091	COG0049	tRNA binding
J163_01092	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J163_01093	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J163_01094	COG0051	transcription antitermination factor activity, RNA binding
J163_01095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J163_01096	COG0088	Forms part of the polypeptide exit tunnel
J163_01097	COG0089	rRNA binding
J163_01098	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J163_01099	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J163_01100	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J163_01101	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J163_01102	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J163_01103	COG0255	Belongs to the universal ribosomal protein uL29 family
J163_01104	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J163_01105	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J163_01106	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J163_01107	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J163_01108	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J163_01109	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J163_01110	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J163_01111	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J163_01112	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J163_01113	COG1841	ribosomal large subunit assembly
J163_01114	COG0200	Binds to the 23S rRNA
J163_01115	COG0201	protein transport
J163_01116	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J163_01117	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J163_01118	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J163_01119	COG0202	RNA polymerase activity
J163_01120	COG0203	ribosomal protein L17
J163_01121	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
J163_01123	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
J163_01125	COG0154	amidase activity
J163_01128	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J163_01129	COG0039	L-malate dehydrogenase activity
J163_01130	COG0625	glutathione transferase activity
J163_01132	COG1902	pentaerythritol trinitrate reductase activity
J163_01132	COG0446	pyridine nucleotide-disulphide oxidoreductase
J163_01133	COG0604	alcohol dehydrogenase
J163_01138	COG0156	8-amino-7-oxononanoate synthase activity
J163_01139	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
J163_01140	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
J163_01141	COG4208	sulfate ABC transporter
J163_01142	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J163_01144	COG1063	alcohol dehydrogenase
J163_01149	COG0406	alpha-ribazole phosphatase activity
J163_01150	COG0285	dihydrofolate synthase activity
J163_01154	COG2833	Protein of unknown function (DUF455)
J163_01156	COG3291	Pkd domain containing protein
J163_01158	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J163_01160	COG0671	phosphoesterase, PA-phosphatase related
J163_01161	COG0438	transferase activity, transferring glycosyl groups
J163_01163	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J163_01166	COG4783	chaperone-mediated protein folding
J163_01169	COG0473	3-isopropylmalate dehydrogenase activity
J163_01175	COG2801	Transposase and inactivated derivatives
J163_01176	COG2963	transposase activity
J163_01199	COG2963	transposase activity
J163_01203	COG3852	Histidine kinase
J163_01206	COG0544	peptidyl-prolyl cis-trans isomerase activity
J163_01207	COG0740	serine-type endopeptidase activity
J163_01208	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J163_01214	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J163_01217	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J163_01219	COG0328	RNA-DNA hybrid ribonuclease activity
J163_01220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J163_01221	COG0631	protein serine/threonine phosphatase activity
J163_01224	COG0859	PFAM glycosyl transferase family 9
J163_01225	COG3642	lipopolysaccharide core region biosynthetic process
J163_01226	COG1234	tRNA 3'-trailer cleavage
J163_01227	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J163_01228	COG0315	cyclic pyranopterin monophosphate synthase activity
J163_01229	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
J163_01230	COG0314	molybdopterin synthase activity
J163_01233	COG2963	transposase activity
J163_01234	COG2801	Transposase and inactivated derivatives
J163_01241	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
J163_01242	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J163_01243	COG0537	adenosine 5'-monophosphoramidase activity
J163_01247	COG0714	Associated with various cellular activities
J163_01251	COG0424	maF-like protein
J163_01252	COG1399	metal-binding, possibly nucleic acid-binding protein
J163_01253	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J163_01254	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J163_01257	COG1028	Short-chain dehydrogenase reductase Sdr
J163_01258	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J163_01260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J163_01261	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J163_01266	COG3829	transcription factor binding
J163_01270	COG3609	addiction module antidote protein, CC2985 family
J163_01275	COG2373	Large extracellular alpha-helical protein
J163_01278	COG4953	penicillin-binding protein 1C
J163_01280	COG0678	peroxiredoxin activity
J163_01286	COG0330	HflC and HflK could
J163_01287	COG0330	HflC and HflK could
J163_01289	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J163_01290	COG0308	aminopeptidase N
J163_01292	COG1028	Short-chain dehydrogenase reductase Sdr
J163_01293	COG1309	transcriptional regulator
J163_01306	COG0328	RNA-DNA hybrid ribonuclease activity
J163_01306	COG0406	alpha-ribazole phosphatase activity
J163_01307	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J163_01309	COG3387	PFAM Glycoside hydrolase 15-related
J163_01310	COG1028	Short-chain dehydrogenase reductase Sdr
J163_01311	COG3537	Alpha-1,2-mannosidase
J163_01315	COG0492	ferredoxin-NADP+ reductase activity
J163_01320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J163_01321	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J163_01322	COG2080	2 iron, 2 sulfur cluster binding
J163_01329	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J163_01332	COG0587	DNA-directed DNA polymerase activity
J163_01335	COG1297	OPT oligopeptide transporter protein
J163_01338	COG1506	peptidase
J163_01338	COG0823	Involved in the tonB-independent uptake of proteins
J163_01341	COG1917	Cupin 2, conserved barrel domain protein
J163_01341	COG2207	Transcriptional regulator
J163_01346	COG0753	catalase activity
J163_01347	COG0656	L-ascorbic acid biosynthetic process
J163_01349	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J163_01349	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J163_01352	COG2814	Major facilitator Superfamily
J163_01355	COG2194	sulfuric ester hydrolase activity
J163_01358	COG0745	RESPONSE REGULATOR receiver
J163_01359	COG0642	Histidine kinase
J163_01361	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
J163_01362	COG2894	cell division
J163_01363	COG0850	regulation of cytokinetic process
J163_01365	COG4585	Histidine kinase
J163_01366	COG2197	response regulator
J163_01369	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
J163_01374	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
J163_01376	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
J163_01381	COG1946	Acyl-CoA thioesterase
J163_01384	COG0824	Thioesterase
J163_01385	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J163_01386	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J163_01387	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J163_01388	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J163_01389	COG0268	Binds directly to 16S ribosomal RNA
J163_01391	COG0196	riboflavin kinase activity
J163_01392	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J163_01393	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J163_01394	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J163_01397	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J163_01398	COG1845	cytochrome c oxidase, subunit III
J163_01399	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
J163_01402	COG3152	Membrane
J163_01404	COG2207	Transcriptional regulator
J163_01405	COG0326	Molecular chaperone. Has ATPase activity
J163_01407	COG1366	Belongs to the anti-sigma-factor antagonist family
J163_01408	COG1366	Belongs to the anti-sigma-factor antagonist family
J163_01409	COG2172	sigma factor antagonist activity
J163_01414	COG4771	TonB-dependent receptor
J163_01416	COG5507	3-demethylubiquinone-9 3-methyltransferase
J163_01417	COG2205	protein histidine kinase activity
J163_01419	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J163_01420	COG2205	protein histidine kinase activity
J163_01420	COG3437	response regulator, receiver
J163_01420	COG3850	Histidine kinase
J163_01420	COG4999	Histidine kinase
J163_01421	COG0784	Response regulator, receiver
J163_01421	COG4191	Histidine kinase
J163_01426	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J163_01427	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J163_01429	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J163_01430	COG0228	four-way junction DNA binding
J163_01431	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J163_01432	COG0336	Belongs to the RNA methyltransferase TrmD family
J163_01433	COG0335	large ribosomal subunit rRNA binding
J163_01434	COG0534	Mate efflux family protein
J163_01435	COG0534	Mate efflux family protein
J163_01439	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
J163_01441	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J163_01444	COG3209	COG3209 Rhs family protein
J163_01448	COG3250	beta-galactosidase activity
J163_01449	COG3867	Arabinogalactan endo-beta-1,4-galactanase
J163_01453	COG1960	acyl-CoA dehydrogenase activity
J163_01454	COG1024	Enoyl-CoA hydratase
J163_01458	COG1250	3-hydroxyacyl-CoA dehydrogenase
J163_01458	COG1024	Enoyl-CoA hydratase
J163_01461	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J163_01462	COG0481	GTPase activity
J163_01465	COG0571	ribonuclease III activity
J163_01466	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J163_01467	COG1381	Involved in DNA repair and RecF pathway recombination
J163_01469	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J163_01471	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J163_01472	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
J163_01473	COG3046	protein related to deoxyribodipyrimidine photolyase
J163_01474	COG1472	Belongs to the glycosyl hydrolase 3 family
J163_01476	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
J163_01477	COG1278	Cold shock
J163_01478	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J163_01480	COG1201	RNA secondary structure unwinding
J163_01481	COG1793	dna ligase
J163_01483	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J163_01483	COG1793	dna ligase
J163_01486	COG0745	RESPONSE REGULATOR receiver
J163_01486	COG3706	GGDEF domain
J163_01489	COG0183	Belongs to the thiolase family
J163_01493	COG1451	nucleotide metabolic process
J163_01494	COG5487	UPF0391 membrane protein
J163_01496	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J163_01499	COG1077	Cell shape determining protein MreB Mrl
J163_01500	COG1047	Peptidyl-prolyl cis-trans
J163_01502	COG2824	Alkylphosphonate utilization operon protein PhnA
J163_01503	COG1902	pentaerythritol trinitrate reductase activity
J163_01504	COG2814	Major facilitator Superfamily
J163_01511	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
J163_01511	COG0392	lysyltransferase activity
J163_01514	COG0251	oxidation-reduction process
J163_01515	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J163_01518	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J163_01523	COG1595	DNA-templated transcription, initiation
J163_01526	COG2878	Part of a membrane complex involved in electron transport
J163_01528	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J163_01528	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J163_01531	COG1131	(ABC) transporter
J163_01532	COG0346	lactoylglutathione lyase activity
J163_01533	COG0833	amino acid
J163_01534	COG2040	homocysteine
J163_01536	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J163_01540	COG1695	Transcriptional regulator
J163_01547	COG0825	malonyl-CoA metabolic process
J163_01549	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J163_01550	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J163_01551	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J163_01552	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J163_01553	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J163_01556	COG0750	zinc metalloprotease
J163_01557	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J163_01558	COG0575	Belongs to the CDS family
J163_01559	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J163_01560	COG0233	cytoplasmic translational termination
J163_01561	COG0528	UMP kinase activity
J163_01562	COG0745	RESPONSE REGULATOR receiver
J163_01562	COG3706	GGDEF domain
J163_01563	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J163_01564	COG0052	Belongs to the universal ribosomal protein uS2 family
J163_01571	COG0024	Methionine aminopeptidase
J163_01572	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
J163_01574	COG1393	Belongs to the ArsC family
J163_01575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J163_01576	COG0367	asparagine synthase
J163_01578	COG4774	siderophore transport
J163_01582	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J163_01588	COG1566	PFAM secretion protein HlyD family protein
J163_01589	COG2814	Major facilitator Superfamily
J163_01593	COG3104	oligopeptide transport
J163_01599	COG0339	signal peptide processing
J163_01600	COG0386	Belongs to the glutathione peroxidase family
J163_01611	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J163_01612	COG0084	hydrolase, TatD family'
J163_01615	COG1960	acyl-CoA dehydrogenase activity
J163_01618	COG0367	asparagine synthase
J163_01620	COG0305	Participates in initiation and elongation during chromosome replication
J163_01621	COG0415	Belongs to the DNA photolyase family
J163_01624	COG0583	DNA-binding transcription factor activity
J163_01631	COG3706	GGDEF domain
J163_01633	COG3706	GGDEF domain
J163_01660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J163_01663	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J163_01665	COG0497	DNA recombination
J163_01666	COG1420	regulation of RNA biosynthetic process
J163_01667	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J163_01668	COG0443	Heat shock 70 kDa protein
J163_01669	COG0484	heat shock protein binding
J163_01671	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
J163_01677	COG0583	DNA-binding transcription factor activity
J163_01678	COG1132	(ABC) transporter
J163_01685	COG2850	peptidyl-arginine hydroxylation
J163_01689	COG1253	flavin adenine dinucleotide binding
J163_01695	COG1131	(ABC) transporter
J163_01696	COG1725	Transcriptional regulator
J163_01698	COG0386	Belongs to the glutathione peroxidase family
J163_01701	COG2900	Belongs to the SlyX family
J163_01706	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J163_01708	COG0646	methionine synthase
J163_01708	COG1410	methionine synthase
J163_01709	COG1410	methionine synthase
J163_01709	COG0646	methionine synthase
J163_01711	COG1960	acyl-CoA dehydrogenase activity
J163_01714	COG0557	exoribonuclease II activity
J163_01716	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J163_01717	COG3706	GGDEF domain
J163_01718	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J163_01720	COG0704	Plays a role in the regulation of phosphate uptake
J163_01721	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J163_01722	COG0581	inorganic phosphate transmembrane transporter activity
J163_01723	COG0573	inorganic phosphate transmembrane transporter activity
J163_01724	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J163_01729	COG0659	secondary active sulfate transmembrane transporter activity
J163_01730	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J163_01732	COG1024	Enoyl-CoA hydratase
J163_01734	COG0494	nUDIX hydrolase
J163_01742	COG0116	Belongs to the methyltransferase superfamily
J163_01742	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J163_01743	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J163_01747	COG2925	Exonuclease
J163_01748	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J163_01749	COG3844	kynureninase activity
J163_01751	COG0662	Cupin 2, conserved barrel domain protein
J163_01752	COG0288	reversible hydration of carbon dioxide
J163_01764	COG2808	Putative FMN-binding domain
J163_01768	COG0017	Asparaginyl-tRNA synthetase
J163_01769	COG0316	Belongs to the HesB IscA family
J163_01770	COG0360	Binds together with S18 to 16S ribosomal RNA
J163_01771	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J163_01772	COG0359	binds to the 23S rRNA
J163_01774	COG3115	cell septum assembly
J163_01776	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J163_01777	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J163_01778	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
J163_01780	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
J163_01782	COG4993	Dehydrogenase
J163_01784	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
J163_01786	COG2986	histidine ammonia-lyase
J163_01787	COG1228	amidohydrolase
J163_01795	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
J163_01796	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J163_01797	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
J163_01798	COG0077	Prephenate dehydratase
J163_01798	COG1605	Chorismate mutase
J163_01799	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J163_01802	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J163_01803	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J163_01804	COG0583	DNA-binding transcription factor activity
J163_01807	COG0840	transmembrane signaling receptor activity
J163_01811	COG0745	RESPONSE REGULATOR receiver
J163_01812	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
J163_01813	COG4191	Histidine kinase
J163_01813	COG0784	Response regulator, receiver
J163_01816	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J163_01818	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
J163_01820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J163_01823	COG1595	DNA-templated transcription, initiation
J163_01834	COG2244	polysaccharide biosynthetic process
J163_01840	COG2264	protein methyltransferase activity
J163_01842	COG0438	transferase activity, transferring glycosyl groups
J163_01845	COG1136	(ABC) transporter
J163_01847	COG0477	Major facilitator Superfamily
J163_01848	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J163_01851	COG1253	flavin adenine dinucleotide binding
J163_01853	COG0306	phosphate transporter
J163_01858	COG0504	CTP synthase activity
J163_01859	COG2877	3-deoxy-8-phosphooctulonate synthase activity
J163_01861	COG0148	phosphopyruvate hydratase activity
J163_01862	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
J163_01863	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J163_01864	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J163_01865	COG0585	pseudouridine synthase activity
J163_01866	COG2840	Smr protein MutS2
J163_01867	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
J163_01868	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J163_01869	COG1238	metal cluster binding
J163_01873	COG1534	Rna-binding protein
J163_01874	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
J163_01875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J163_01876	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J163_01877	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J163_01878	COG1923	regulation of RNA biosynthetic process
J163_01879	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J163_01880	COG1546	Belongs to the CinA family
J163_01882	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J163_01883	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J163_01884	COG2137	regulation of response to DNA damage stimulus
J163_01885	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J163_01886	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
J163_01889	COG1741	Belongs to the pirin family
J163_01890	COG0583	DNA-binding transcription factor activity
J163_01895	COG0351	phosphomethylpyrimidine kinase
J163_01895	COG0352	thiamine-phosphate diphosphorylase activity
J163_01898	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
J163_01899	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J163_01902	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J163_01904	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
J163_01905	COG3734	2-keto-3-deoxy-galactonokinase
J163_01907	COG4948	Mandelate Racemase Muconate Lactonizing
J163_01908	COG0800	Aldolase
J163_01916	COG1501	Belongs to the glycosyl hydrolase 31 family
J163_01918	COG1070	Carbohydrate kinase
J163_01919	COG2115	Belongs to the xylose isomerase family
J163_01920	COG0477	Major facilitator Superfamily
J163_01923	COG0860	N-Acetylmuramoyl-L-alanine amidase
J163_01924	COG1469	GTP cyclohydrolase I activity
J163_01930	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J163_01931	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
J163_01932	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
J163_01933	COG0166	Belongs to the GPI family
J163_01937	COG1472	Belongs to the glycosyl hydrolase 3 family
J163_01939	COG2203	Gaf domain
J163_01939	COG5001	Diguanylate cyclase
J163_01939	COG4251	negative regulation of phosphorylation
J163_01939	COG3706	GGDEF domain
J163_01940	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J163_01941	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
J163_01943	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J163_01944	COG0671	phosphoesterase, PA-phosphatase related
J163_01946	COG1794	racemase activity, acting on amino acids and derivatives
J163_01947	COG0697	spore germination
J163_01948	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J163_01949	COG0167	dihydroorotate dehydrogenase activity
J163_01952	COG1012	belongs to the aldehyde dehydrogenase family
J163_01955	COG1215	transferase activity, transferring glycosyl groups
J163_01956	COG1649	PFAM Uncharacterised BCR, COG1649
J163_01956	COG0726	polysaccharide deacetylase
J163_01959	COG3210	domain, Protein
J163_01960	COG3210	domain, Protein
J163_01969	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J163_01970	COG0124	histidyl-tRNA synthetase
J163_01972	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J163_01973	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J163_01974	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J163_01975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
J163_01975	COG0131	Imidazoleglycerol-phosphate dehydratase
J163_01976	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J163_01977	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J163_01978	COG0107	imidazoleglycerol-phosphate synthase activity
J163_01979	COG0140	phosphoribosyl-ATP diphosphatase activity
J163_01979	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J163_01982	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
J163_01983	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
J163_01984	COG0235	Class ii aldolase
J163_01985	COG0531	amino acid
J163_01986	COG0531	amino acid
J163_01988	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J163_01989	COG0277	FAD linked oxidase domain protein
J163_01993	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J163_02002	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J163_02003	COG2258	MOSC domain
J163_02004	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J163_02005	COG0505	Belongs to the CarA family
J163_02007	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J163_02008	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J163_02010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J163_02018	COG3279	Response regulator of the LytR AlgR family
J163_02019	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
J163_02020	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J163_02022	COG2198	Histidine kinase
J163_02022	COG2205	protein histidine kinase activity
J163_02022	COG0784	Response regulator, receiver
J163_02023	COG1024	Enoyl-CoA hydratase
J163_02024	COG0318	PFAM AMP-dependent synthetase and ligase
J163_02030	COG2267	carboxylic ester hydrolase activity
J163_02032	COG2201	protein-glutamate methylesterase activity
J163_02033	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
J163_02035	COG0840	transmembrane signaling receptor activity
J163_02036	COG0840	transmembrane signaling receptor activity
J163_02037	COG0840	transmembrane signaling receptor activity
J163_02038	COG0840	transmembrane signaling receptor activity
J163_02039	COG0840	transmembrane signaling receptor activity
J163_02040	COG0840	transmembrane signaling receptor activity
J163_02041	COG0840	transmembrane signaling receptor activity
J163_02043	COG0840	transmembrane signaling receptor activity
J163_02044	COG0840	transmembrane signaling receptor activity
J163_02044	COG0840	transmembrane signaling receptor activity
J163_02046	COG0840	transmembrane signaling receptor activity
J163_02047	COG0643	Histidine kinase
J163_02047	COG2198	Histidine kinase
J163_02048	COG0745	RESPONSE REGULATOR receiver
J163_02050	COG0835	chemotaxis
J163_02051	COG1192	Involved in chromosome partitioning
J163_02052	COG1360	Flagellar Motor Protein
J163_02053	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
J163_02065	COG2801	Transposase and inactivated derivatives
J163_02066	COG2963	transposase activity
J163_02072	COG0641	radical SAM
J163_02075	COG0643	Histidine kinase
J163_02075	COG2198	Histidine kinase
J163_02079	COG0455	bacterial-type flagellum organization
J163_02081	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J163_02084	COG5001	Diguanylate cyclase
J163_02084	COG3300	MHYT domain
J163_02085	COG5001	Diguanylate cyclase
J163_02085	COG3300	MHYT domain
J163_02086	COG1684	flagellar biosynthetic protein fliR
J163_02087	COG1987	bacterial-type flagellum assembly
J163_02090	COG3190	flagellar
J163_02100	COG1677	Flagellar hook-basal body complex protein FliE
J163_02107	COG1028	Short-chain dehydrogenase reductase Sdr
J163_02108	COG1028	Short-chain dehydrogenase reductase Sdr
J163_02109	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J163_02112	COG2204	response regulator
J163_02113	COG2201	protein-glutamate methylesterase activity
J163_02119	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
J163_02120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J163_02121	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J163_02123	COG3951	Flagellar rod assembly protein muramidase FlgJ
J163_02123	COG1705	Flagellar rod assembly protein muramidase FlgJ
J163_02124	COG1706	bacterial-type flagellum-dependent cell motility
J163_02125	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
J163_02126	COG4786	Flagellar basal body rod
J163_02127	COG4787	bacterial-type flagellum-dependent cell motility
J163_02128	COG1749	Flagellar hook protein flgE
J163_02129	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
J163_02130	COG1558	bacterial-type flagellum-dependent cell motility
J163_02132	COG0835	chemotaxis
J163_02132	COG0784	Response regulator, receiver
J163_02136	COG5002	protein histidine kinase activity
J163_02142	COG2915	High frequency lysogenization protein hflD homolog
J163_02143	COG0482	sulfurtransferase activity
J163_02145	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
J163_02146	COG0542	response to heat
J163_02147	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J163_02148	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
J163_02150	COG0492	ferredoxin-NADP+ reductase activity
J163_02151	COG1674	ftsk spoiiie
J163_02153	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
J163_02155	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J163_02157	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J163_02159	COG0183	Belongs to the thiolase family
J163_02160	COG1024	Enoyl-CoA hydratase
J163_02160	COG1250	3-hydroxyacyl-CoA dehydrogenase
J163_02162	COG0105	UTP biosynthetic process
J163_02163	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J163_02165	COG1426	Protein conserved in bacteria
J163_02167	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J163_02168	COG1160	GTP binding
J163_02169	COG0303	'Molybdopterin
J163_02170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J163_02177	COG0708	Exodeoxyribonuclease III
J163_02179	COG0303	'Molybdopterin
J163_02180	COG0746	molybdenum cofactor guanylyltransferase activity
J163_02183	COG1914	H( )-stimulated, divalent metal cation uptake system
J163_02184	COG1321	iron dependent repressor
J163_02185	COG0590	tRNA wobble adenosine to inosine editing
J163_02186	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
J163_02187	COG0668	transmembrane transport
J163_02189	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
J163_02192	COG1028	Short-chain dehydrogenase reductase Sdr
J163_02193	COG1183	phosphatidylcholine synthase activity
J163_02195	COG3243	poly(R)-hydroxyalkanoic acid synthase
J163_02198	COG0723	plastoquinol--plastocyanin reductase activity
J163_02198	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J163_02200	COG2183	response to ionizing radiation
J163_02201	COG0784	Response regulator, receiver
J163_02201	COG2205	protein histidine kinase activity
J163_02214	COG0800	Aldolase
J163_02215	COG0129	dihydroxy-acid dehydratase activity
J163_02216	COG0363	glucosamine-6-phosphate deaminase activity
J163_02217	COG0837	glucose binding
J163_02218	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J163_02223	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
J163_02226	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J163_02227	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
J163_02229	COG4591	ABC-type transport system involved in lipoprotein release permease component
J163_02230	COG1136	(ABC) transporter
J163_02233	COG0811	peptide transport
J163_02235	COG1132	(ABC) transporter
J163_02236	COG1663	tetraacyldisaccharide 4'-kinase activity
J163_02237	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
J163_02238	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J163_02240	COG0322	excinuclease ABC activity
J163_02241	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J163_02245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J163_02246	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J163_02250	COG2963	transposase activity
J163_02251	COG0582	viral genome integration into host DNA
J163_02253	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
J163_02259	COG1530	ribonuclease E activity
J163_02261	COG3064	Membrane
J163_02262	COG0428	transporter
J163_02264	COG2154	pterin-4-alpha-carbinolamine dehydratase
J163_02265	COG0316	Belongs to the HesB IscA family
J163_02265	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
J163_02274	COG2226	methyltransferase
J163_02274	COG1073	alpha beta
J163_02276	COG1028	Short-chain dehydrogenase reductase Sdr
J163_02277	COG2801	Transposase and inactivated derivatives
J163_02278	COG2963	transposase activity
J163_02280	COG1238	metal cluster binding
J163_02286	COG3279	Response regulator of the LytR AlgR family
J163_02294	COG4566	intracellular signal transduction
J163_02296	COG5001	Diguanylate cyclase
J163_02299	COG3685	Protein conserved in bacteria
J163_02303	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J163_02303	COG1648	precorrin-2 dehydrogenase activity
J163_02306	COG2814	Major facilitator Superfamily
J163_02309	COG1335	isochorismatase
J163_02312	COG2197	response regulator
J163_02315	COG0583	DNA-binding transcription factor activity
J163_02316	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J163_02317	COG3002	Belongs to the UPF0753 family
J163_02318	COG2801	Transposase and inactivated derivatives
J163_02319	COG2963	transposase activity
J163_02320	COG1396	sequence-specific DNA binding
J163_02321	COG5489	Protein of unknown function (DUF736)
J163_02322	COG2003	Belongs to the UPF0758 family
J163_02327	COG0582	viral genome integration into host DNA
J163_02330	COG4774	siderophore transport
J163_02334	COG2336	PFAM SpoVT AbrB
J163_02339	COG4206	TonB-dependent receptor
J163_02344	COG2273	Hydrolase Family 16
J163_02344	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
J163_02349	COG2274	protein secretion by the type I secretion system
J163_02351	COG1192	Involved in chromosome partitioning
J163_02359	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J163_02360	COG0270	DNA (cytosine-5-)-methyltransferase activity
J163_02372	COG4804	nuclease activity
J163_02373	COG2963	transposase activity
J163_02374	COG2801	Transposase and inactivated derivatives
J163_02375	COG5006	permease, DMT superfamily
J163_02378	COG2249	NAD(P)H dehydrogenase (quinone) activity
J163_02380	COG3938	Belongs to the proline racemase family
J163_02381	COG0655	NAD(P)H dehydrogenase (quinone) activity
J163_02383	COG2807	transmembrane transport
J163_02384	COG2207	Transcriptional regulator
J163_02414	COG0210	DNA helicase
J163_02430	COG2084	Dehydrogenase
J163_02435	COG2003	Belongs to the UPF0758 family
J163_02442	COG0582	viral genome integration into host DNA
J163_02443	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J163_02443	COG0519	Catalyzes the synthesis of GMP from XMP
J163_02445	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J163_02447	COG0475	glutathione-regulated potassium exporter activity
J163_02447	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J163_02448	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J163_02450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J163_02451	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
J163_02453	COG0776	regulation of translation
J163_02454	COG0539	negative regulation of cytoplasmic translation
J163_02455	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J163_02456	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J163_02459	COG2957	Belongs to the agmatine deiminase family
J163_02460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J163_02465	COG0395	ABC-type sugar transport system, permease component
J163_02466	COG1175	transmembrane transport
J163_02472	COG2350	Protein conserved in bacteria
J163_02473	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
J163_02474	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J163_02475	COG1187	pseudouridine synthase activity
J163_02479	COG0436	Aminotransferase
J163_02480	COG4133	protoheme IX ABC transporter activity
J163_02484	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
J163_02485	COG1138	Cytochrome C-type biogenesis protein
J163_02489	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J163_02490	COG1278	Cold shock
J163_02491	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
J163_02492	COG4988	ABC transporter
J163_02494	COG1294	oxidase, subunit
J163_02499	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J163_02500	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J163_02502	COG0165	Argininosuccinate lyase
J163_02503	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J163_02505	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J163_02508	COG0137	argininosuccinate synthase activity
J163_02509	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J163_02511	COG0215	cysteine-tRNA ligase activity
J163_02512	COG2166	iron-sulfur cluster assembly
J163_02514	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J163_02515	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J163_02516	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J163_02521	COG4302	ethanolamine ammonia-lyase activity
J163_02527	COG2963	transposase activity
J163_02533	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J163_02534	COG0402	S-adenosylhomocysteine deaminase activity
J163_02536	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J163_02537	COG1509	lysine 2,3-aminomutase activity
J163_02538	COG3300	MHYT domain
J163_02538	COG5001	Diguanylate cyclase
J163_02541	COG0483	inositol monophosphate 1-phosphatase activity
J163_02546	COG0513	Belongs to the DEAD box helicase family
J163_02547	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J163_02548	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
J163_02550	COG0625	glutathione transferase activity
J163_02552	COG4681	YaeQ
J163_02553	COG2081	HI0933 family
J163_02555	COG0501	Belongs to the peptidase M48B family
J163_02556	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J163_02557	COG1028	Short-chain dehydrogenase reductase Sdr
J163_02561	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J163_02562	COG0860	N-Acetylmuramoyl-L-alanine amidase
J163_02563	COG0802	atpase or kinase
J163_02564	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J163_02564	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J163_02565	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J163_02566	COG1570	exodeoxyribonuclease VII activity
J163_02568	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J163_02607	COG0835	chemotaxis
J163_02608	COG0840	transmembrane signaling receptor activity
J163_02609	COG2094	Belongs to the DNA glycosylase MPG family
J163_02610	COG1201	RNA secondary structure unwinding
J163_02613	COG2969	positive regulation of protein catabolic process
J163_02614	COG0625	glutathione transferase activity
J163_02615	COG2857	Cytochrome c1
J163_02616	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J163_02617	COG0723	plastoquinol--plastocyanin reductase activity
J163_02618	COG0741	lytic transglycosylase activity
J163_02621	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J163_02622	COG1702	phosphate starvation-inducible protein PhoH
J163_02624	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J163_02626	COG4535	Mg2 and Co2 transporter CorC
J163_02629	COG1012	belongs to the aldehyde dehydrogenase family
J163_02630	COG1177	transmembrane transport
J163_02631	COG1176	ABC-type spermidine putrescine transport system, permease component I
J163_02632	COG3842	ATPase activity
J163_02636	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
J163_02639	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J163_02640	COG0174	glutamine synthetase
J163_02641	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J163_02642	COG0745	RESPONSE REGULATOR receiver
J163_02642	COG3706	GGDEF domain
J163_02643	COG2703	oxygen carrier activity
J163_02644	COG0477	Major facilitator Superfamily
J163_02646	COG0243	molybdopterin cofactor binding
J163_02647	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
J163_02651	COG2733	membrane
J163_02652	COG2205	protein histidine kinase activity
J163_02652	COG0784	Response regulator, receiver
J163_02652	COG5002	protein histidine kinase activity
J163_02654	COG0477	Major facilitator Superfamily
J163_02655	COG2902	Dehydrogenase
J163_02657	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J163_02658	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J163_02659	COG1609	Transcriptional regulator
J163_02660	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J163_02660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J163_02661	COG1105	Belongs to the carbohydrate kinase PfkB family
J163_02662	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J163_02662	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J163_02670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J163_02672	COG1862	Preprotein translocase
J163_02673	COG0343	queuine tRNA-ribosyltransferase activity
J163_02674	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
J163_02682	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
J163_02683	COG3291	Pkd domain containing protein
J163_02684	COG0405	Gamma-glutamyltransferase
J163_02685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J163_02688	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J163_02689	COG0742	ribosomal rna small subunit methyltransferase
J163_02690	COG0326	Molecular chaperone. Has ATPase activity
J163_02706	COG0531	amino acid
J163_02709	COG0006	proline dipeptidase activity
J163_02711	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J163_02714	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J163_02715	COG3938	Belongs to the proline racemase family
J163_02717	COG0552	protein localization to endoplasmic reticulum
J163_02718	COG1194	a g-specific adenine glycosylase
J163_02719	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
J163_02720	COG0784	Response regulator, receiver
J163_02720	COG4191	Histidine kinase
J163_02723	COG0322	excinuclease ABC activity
J163_02726	COG3040	lipid binding
J163_02728	COG1960	acyl-CoA dehydrogenase activity
J163_02730	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J163_02734	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J163_02735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J163_02736	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J163_02743	COG0438	transferase activity, transferring glycosyl groups
J163_02744	COG0438	transferase activity, transferring glycosyl groups
J163_02753	COG0776	regulation of translation
J163_02754	COG0072	phenylalanine-tRNA ligase activity
J163_02754	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J163_02755	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J163_02756	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J163_02757	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J163_02759	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J163_02760	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J163_02765	COG1082	Xylose isomerase domain protein TIM barrel
J163_02769	COG0366	Alpha amylase catalytic
J163_02771	COG2963	transposase activity
J163_02772	COG2801	Transposase and inactivated derivatives
J163_02785	COG2948	multi-organism process
J163_02789	COG3505	Type IV secretory pathway VirD4
J163_02792	COG0556	nucleotide-excision repair
J163_02800	COG2963	transposase activity
J163_02801	COG2801	Transposase and inactivated derivatives
J163_02808	COG4695	Portal protein
J163_02817	COG3179	chitinase
J163_02827	COG2801	Transposase and inactivated derivatives
J163_02828	COG2963	transposase activity
J163_02834	COG3275	phosphorelay sensor kinase activity
J163_02835	COG1611	Belongs to the LOG family
J163_02837	COG2095	MarC family integral membrane protein
J163_02839	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J163_02840	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J163_02846	COG1185	polyribonucleotide nucleotidyltransferase activity
J163_02847	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J163_02848	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J163_02849	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J163_02850	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J163_02851	COG0195	Participates in both transcription termination and antitermination
J163_02852	COG0779	Required for maturation of 30S ribosomal subunits
J163_02854	COG1007	ATP synthesis coupled electron transport
J163_02857	COG0713	ATP synthesis coupled electron transport
J163_02859	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J163_02860	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
J163_02862	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J163_02863	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
J163_02864	COG0649	NAD binding
J163_02865	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J163_02866	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J163_02867	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J163_02870	COG0149	triose-phosphate isomerase activity
J163_02871	COG0300	oxidoreductase activity
J163_02877	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J163_02878	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
J163_02879	COG0159	tryptophan synthase activity
J163_02881	COG0133	tryptophan synthase activity
J163_02883	COG0135	phosphoribosylanthranilate isomerase activity
J163_02884	COG0101	tRNA pseudouridine synthase activity
J163_02888	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J163_02889	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J163_02890	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J163_02891	COG2890	protein-(glutamine-N5) methyltransferase activity
J163_02893	COG0688	phosphatidylethanolamine metabolic process
J163_02895	COG0433	COG0433 Predicted ATPase
J163_02896	COG0494	nUDIX hydrolase
J163_02899	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J163_02900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J163_02905	COG0717	Belongs to the dCTP deaminase family
J163_02906	COG0489	protein tyrosine kinase activity
J163_02910	COG3590	peptidase
J163_02911	COG3590	peptidase
J163_02915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J163_02916	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J163_02917	COG2311	Membrane
J163_02918	COG1047	Peptidyl-prolyl cis-trans
J163_02919	COG0791	NLP P60 protein
J163_02920	COG0791	NLP P60 protein
J163_02922	COG4106	trans-aconitate 2-methyltransferase activity
J163_02923	COG1301	dicarboxylic acid transport
J163_02924	COG1785	Belongs to the alkaline phosphatase family
J163_02925	COG0037	tRNA processing
J163_02926	COG1722	exodeoxyribonuclease VII activity
J163_02927	COG0142	geranyltranstransferase activity
J163_02928	COG4104	PAAR repeat-containing protein
J163_02930	COG0312	modulator of DNA gyrase
J163_02931	COG3028	Belongs to the UPF0307 family
J163_02932	COG0312	modulator of DNA gyrase
J163_02934	COG3164	Protein of unknown function
J163_02935	COG1530	ribonuclease E activity
J163_02936	COG0424	maF-like protein
J163_02937	COG2968	Membrane
J163_02940	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J163_02943	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J163_02946	COG0495	leucyl-tRNA aminoacylation
J163_02948	COG3118	belongs to the thioredoxin family
J163_02953	COG2155	Conserved Protein
J163_02954	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J163_02961	COG1132	(ABC) transporter
J163_02967	COG1538	Outer membrane efflux protein
J163_02968	COG0745	RESPONSE REGULATOR receiver
J163_02969	COG5000	phosphorelay sensor kinase activity
J163_02969	COG5002	protein histidine kinase activity
J163_02970	COG0475	glutathione-regulated potassium exporter activity
J163_02971	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J163_02972	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J163_02975	COG0745	RESPONSE REGULATOR receiver
J163_02975	COG3706	GGDEF domain
J163_02976	COG1187	pseudouridine synthase activity
J163_02977	COG5001	Diguanylate cyclase
J163_02977	COG5002	protein histidine kinase activity
J163_03001	COG0667	Aldo Keto reductase
J163_03002	COG2814	Major facilitator Superfamily
J163_03003	COG0583	DNA-binding transcription factor activity
J163_03005	COG2207	Transcriptional regulator
J163_03007	COG1309	transcriptional regulator
J163_03008	COG1538	Outer membrane efflux protein
J163_03012	COG0735	belongs to the Fur family
J163_03013	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J163_03018	COG4452	Inner membrane protein CreD
J163_03020	COG2205	protein histidine kinase activity
J163_03021	COG0745	RESPONSE REGULATOR receiver
J163_03022	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
J163_03024	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J163_03031	COG2198	Histidine kinase
J163_03031	COG0643	Histidine kinase
J163_03032	COG0840	transmembrane signaling receptor activity
J163_03033	COG0835	chemotaxis
J163_03034	COG2202	Pas domain
J163_03034	COG2200	EAL domain
J163_03034	COG2199	diguanylate cyclase activity
J163_03035	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J163_03036	COG2201	protein-glutamate methylesterase activity
J163_03037	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J163_03038	COG3590	peptidase
J163_03040	COG0588	phosphoglycerate mutase activity
J163_03041	COG1515	deoxyribonuclease V activity
J163_03043	COG1741	Belongs to the pirin family
J163_03046	COG1741	Belongs to the pirin family
J163_03047	COG1966	Carbon starvation protein
J163_03048	COG2879	small protein
J163_03059	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
J163_03060	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J163_03061	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J163_03062	COG2080	2 iron, 2 sulfur cluster binding
J163_03064	COG3706	GGDEF domain
J163_03064	COG4251	negative regulation of phosphorylation
J163_03064	COG2203	Gaf domain
J163_03064	COG5001	Diguanylate cyclase
J163_03065	COG0629	single-stranded DNA binding
J163_03066	COG0142	geranyltranstransferase activity
J163_03068	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J163_03071	COG0527	aspartate kinase activity
J163_03072	COG0384	phenazine biosynthesis protein PhzF
J163_03073	COG0384	phenazine biosynthesis protein PhzF
J163_03075	COG1764	response to oxidative stress
J163_03076	COG0540	Belongs to the ATCase OTCase family
J163_03077	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J163_03078	COG1678	Uncharacterized ACR, COG1678
J163_03079	COG0519	Catalyzes the synthesis of GMP from XMP
J163_03082	COG5297	Belongs to the glycosyl hydrolase family 6
J163_03085	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J163_03088	COG0739	heme binding
J163_03092	COG0693	protein deglycase activity
J163_03094	COG1959	2 iron, 2 sulfur cluster binding
J163_03095	COG0719	Fe-S assembly protein
J163_03096	COG0396	ATPase activity
J163_03097	COG0719	Fe-S assembly protein
J163_03098	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J163_03101	COG4774	siderophore transport
J163_03102	COG3128	pkhd-type hydroxylase
J163_03107	COG1477	protein flavinylation
J163_03108	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J163_03111	COG1555	photosystem II stabilization
J163_03112	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J163_03114	COG3178	'Phosphotransferase
J163_03115	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J163_03117	COG0628	permease
J163_03119	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J163_03121	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J163_03125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J163_03126	COG0271	Belongs to the BolA IbaG family
J163_03128	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
J163_03130	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
J163_03131	COG1137	ATPase activity
J163_03134	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J163_03135	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
J163_03136	COG1660	Displays ATPase and GTPase activities
J163_03138	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J163_03139	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J163_03140	COG2239	Acts as a magnesium transporter
J163_03142	COG1294	oxidase, subunit
J163_03143	COG1271	oxidase subunit
J163_03145	COG1113	amino acid transport
J163_03148	COG2197	response regulator
J163_03149	COG0531	amino acid
J163_03154	COG1234	tRNA 3'-trailer cleavage
J163_03161	COG2814	Major facilitator Superfamily
J163_03163	COG0754	glutathionylspermidine amidase activity
J163_03168	COG1842	Phage shock protein A
J163_03170	COG0259	pyridoxamine-phosphate oxidase activity
J163_03171	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J163_03172	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J163_03174	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J163_03188	COG2814	Major facilitator Superfamily
J163_03192	COG2198	Histidine kinase
J163_03192	COG0784	Response regulator, receiver
J163_03192	COG2205	protein histidine kinase activity
J163_03193	COG2353	YceI-like domain
J163_03197	COG1760	l-serine dehydratase
J163_03199	COG0527	aspartate kinase activity
J163_03199	COG0460	homoserine dehydrogenase
J163_03200	COG0626	cystathionine gamma-synthase activity
J163_03201	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J163_03203	COG0739	heme binding
J163_03204	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J163_03205	COG1272	protein, Hemolysin III
J163_03206	COG2982	Protein involved in outer membrane biogenesis
J163_03207	COG0516	GMP reductase activity
J163_03207	COG0517	IMP dehydrogenase activity
J163_03208	COG0463	Glycosyl transferase, family 2
J163_03209	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J163_03210	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
J163_03212	COG4771	TonB-dependent receptor
J163_03214	COG1309	transcriptional regulator
J163_03215	COG2267	carboxylic ester hydrolase activity
J163_03216	COG1960	acyl-CoA dehydrogenase activity
J163_03221	COG0509	glycine decarboxylation via glycine cleavage system
J163_03222	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J163_03224	COG0330	HflC and HflK could
J163_03225	COG1742	UPF0060 membrane protein
J163_03226	COG3956	TIGRFAM MazG family protein
J163_03228	COG0494	nUDIX hydrolase
J163_03230	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J163_03231	COG0837	glucose binding
J163_03234	COG3858	chitin binding
J163_03234	COG1388	LysM domain
J163_03235	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J163_03237	COG1472	Belongs to the glycosyl hydrolase 3 family
J163_03240	COG0531	amino acid
J163_03242	COG1486	melibiose metabolic process
J163_03244	COG3537	Alpha-1,2-mannosidase
J163_03251	COG3142	Participates in the control of copper homeostasis
J163_03252	COG1446	asparaginase
J163_03257	COG0840	transmembrane signaling receptor activity
J163_03261	COG0189	ligase activity
J163_03263	COG1397	ADP-ribosylglycohydrolase
J163_03265	COG1199	ATP-dependent helicase activity
J163_03267	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J163_03268	COG1215	transferase activity, transferring glycosyl groups
J163_03270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J163_03271	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
J163_03272	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
J163_03273	COG0535	radical SAM domain protein
J163_03274	COG0535	radical SAM domain protein
J163_03277	COG0837	glucose binding
J163_03279	COG1643	Atp-dependent helicase
J163_03280	COG0783	Belongs to the Dps family
J163_03281	COG0514	ATP-dependent DNA helicase (RecQ)
J163_03288	COG0840	transmembrane signaling receptor activity
J163_03292	COG3920	Histidine kinase
J163_03293	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
J163_03295	COG0602	queuosine metabolic process
J163_03297	COG2885	chlorophyll binding
J163_03298	COG0823	Involved in the tonB-independent uptake of proteins
J163_03300	COG0848	biopolymer transport protein
J163_03302	COG0824	Thioesterase
J163_03303	COG2255	four-way junction helicase activity
J163_03305	COG3158	transport of potassium into the cell
J163_03306	COG0632	four-way junction helicase activity
J163_03307	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J163_03308	COG0217	transcriptional regulatory protein
J163_03311	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J163_03314	COG0477	Major facilitator Superfamily
J163_03322	COG0488	(ABC) transporter
J163_03328	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J163_03328	COG4651	solute:proton antiporter activity
J163_03333	COG4772	TonB-dependent receptor
J163_03335	COG4264	IucA IucC family
J163_03338	COG0019	diaminopimelate decarboxylase activity
J163_03343	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
J163_03345	COG1492	cobalamin metabolic process
J163_03348	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
J163_03352	COG4206	TonB-dependent receptor
J163_03354	COG0542	response to heat
J163_03355	COG1116	anion transmembrane transporter activity
J163_03356	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J163_03357	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J163_03358	COG0667	Aldo Keto reductase
J163_03360	COG4771	TonB-dependent receptor
J163_03361	COG2827	Endonuclease containing a URI domain
J163_03369	COG1877	trehalose-phosphatase activity
J163_03370	COG3387	PFAM Glycoside hydrolase 15-related
J163_03373	COG0840	transmembrane signaling receptor activity
J163_03374	COG3011	Protein conserved in bacteria
J163_03377	COG0564	pseudouridine synthase activity
J163_03378	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J163_03380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J163_03380	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
J163_03382	COG2963	transposase activity
J163_03383	COG2801	Transposase and inactivated derivatives
J163_03386	COG2951	lytic endotransglycosylase activity
J163_03387	COG4644	lycopene metabolic process
J163_03391	COG2369	cell adhesion
J163_03396	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
J163_03397	COG0045	succinate-CoA ligase (ADP-forming) activity
J163_03401	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J163_03407	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
J163_03408	COG0237	dephospho-CoA kinase activity
J163_03412	COG2963	transposase activity
J163_03414	COG5002	protein histidine kinase activity
J163_03415	COG0745	RESPONSE REGULATOR receiver
J163_03417	COG0189	ligase activity
J163_03431	COG2003	Belongs to the UPF0758 family
J163_03435	COG0784	Response regulator, receiver
J163_03435	COG4191	Histidine kinase
J163_03436	COG0784	Response regulator, receiver
J163_03436	COG4191	Histidine kinase
J163_03455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J163_03460	COG2022	thiamine diphosphate biosynthetic process
J163_03461	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J163_03462	COG3273	potassium ion transport
J163_03462	COG0471	metal ion transport
J163_03466	COG1970	mechanosensitive ion channel activity
J163_03470	COG3250	beta-galactosidase activity
J163_03471	COG4948	Mandelate Racemase Muconate Lactonizing
J163_03474	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J163_03476	COG0308	aminopeptidase N
J163_03478	COG2801	Transposase and inactivated derivatives
J163_03479	COG2963	transposase activity
J163_03485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J163_03487	COG2895	sulfate adenylyltransferase (ATP) activity
J163_03487	COG0529	Catalyzes the synthesis of activated sulfate
J163_03488	COG0175	sulfate reduction
J163_03489	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J163_03490	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J163_03491	COG0175	sulfate reduction
J163_03498	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J163_03498	COG1648	precorrin-2 dehydrogenase activity
J163_03501	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
J163_03502	COG3588	fructose-bisphosphate aldolase
J163_03503	COG0469	pyruvate kinase activity
J163_03505	COG0126	phosphoglycerate kinase activity
J163_03510	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J163_03512	COG3047	cAMP biosynthetic process
J163_03513	COG3047	cAMP biosynthetic process
J163_03515	COG3453	Protein conserved in bacteria
J163_03515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J163_03516	COG0725	ABC transporter, periplasmic molybdate-binding protein
J163_03517	COG4149	molybdate abc transporter
J163_03518	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
J163_03525	COG1376	ErfK ybiS ycfS ynhG family protein
J163_03526	COG0739	heme binding
J163_03528	COG4773	Receptor
J163_03529	COG0596	Alpha beta hydrolase
J163_03530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
J163_03531	COG1301	dicarboxylic acid transport
J163_03533	COG2304	oxidoreductase activity
J163_03537	COG0714	Associated with various cellular activities
J163_03544	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J163_03548	COG0254	rRNA binding
J163_03550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J163_03552	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J163_03553	COG1758	RNA polymerase activity
J163_03554	COG0194	GDP metabolic process
J163_03555	COG1561	YicC-like family, N-terminal region
J163_03556	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J163_03558	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J163_03559	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J163_03562	COG0006	proline dipeptidase activity
J163_03564	COG0006	proline dipeptidase activity
J163_03565	COG0006	proline dipeptidase activity
J163_03566	COG3079	Belongs to the UPF0149 family
J163_03570	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J163_03572	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
J163_03574	COG2912	Transglutaminase-like superfamily
J163_03575	COG1773	rubredoxin
J163_03576	COG0352	thiamine-phosphate diphosphorylase activity
J163_03579	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J163_03582	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J163_03588	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J163_03589	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J163_03590	COG1028	Short-chain dehydrogenase reductase Sdr
J163_03592	COG0671	phosphoesterase, PA-phosphatase related
J163_03593	COG3781	membrane
J163_03595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J163_03596	COG0563	adenylate kinase activity
J163_03599	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
J163_03601	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
J163_03605	COG3710	Transcriptional regulator
J163_03606	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
J163_03609	COG0840	transmembrane signaling receptor activity
J163_03610	COG0405	Gamma-glutamyltransferase
J163_03611	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J163_03615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J163_03616	COG0473	3-isopropylmalate dehydrogenase activity
J163_03617	COG0066	3-isopropylmalate dehydratase activity
J163_03618	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J163_03622	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J163_03623	COG1538	Outer membrane efflux protein
J163_03624	COG1519	Transferase
J163_03625	COG1560	Kdo2-lipid A biosynthetic process
J163_03630	COG0280	phosphate acetyltransferase
J163_03630	COG0281	malic enzyme
J163_03631	COG1301	dicarboxylic acid transport
J163_03636	COG0583	DNA-binding transcription factor activity
J163_03637	COG0667	Aldo Keto reductase
J163_03641	COG2197	response regulator
J163_03642	COG1840	ABC-type Fe3 transport system, periplasmic component
J163_03643	COG0642	Histidine kinase
J163_03646	COG2851	Citrate transporter
J163_03648	COG1028	Short-chain dehydrogenase reductase Sdr
J163_03649	COG1609	Transcriptional regulator
J163_03650	COG2211	Major facilitator Superfamily
J163_03655	COG1162	GTPase activity
J163_03659	COG4773	Receptor
J163_03660	COG0726	polysaccharide deacetylase
J163_03661	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J163_03664	COG2963	transposase activity
J163_03665	COG2801	Transposase and inactivated derivatives
J163_03669	COG1307	EDD domain protein, DegV family
J163_03670	COG0242	peptide deformylase activity
J163_03674	COG0457	Tetratricopeptide repeat
J163_03675	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
J163_03676	COG1215	transferase activity, transferring glycosyl groups
J163_03677	COG1215	transferase activity, transferring glycosyl groups
J163_03680	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
J163_03689	COG2188	Transcriptional regulator
J163_03691	COG1450	Type ii and iii secretion system protein
J163_03694	COG3166	PFAM Fimbrial assembly family protein
J163_03695	COG3156	type II secretion system protein K
J163_03696	COG4795	General secretion pathway protein
J163_03697	COG2165	general secretion pathway protein
J163_03698	COG4970	Tfp pilus assembly protein FimT
J163_03699	COG2165	general secretion pathway protein
J163_03700	COG1459	type II secretion system
J163_03701	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J163_03702	COG1404	Belongs to the peptidase S8 family
J163_03703	COG5295	Hep Hag repeat protein
J163_03704	COG1404	Belongs to the peptidase S8 family
J163_03705	COG5295	Hep Hag repeat protein
J163_03706	COG0047	phosphoribosylformylglycinamidine synthase activity
J163_03706	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J163_03707	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J163_03708	COG4974	Belongs to the 'phage' integrase family
J163_03711	COG0795	lipopolysaccharide-transporting ATPase activity
J163_03713	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J163_03716	COG0525	valine-tRNA ligase activity
J163_03722	COG1183	phosphatidylcholine synthase activity
J163_03724	COG0442	prolyl-tRNA aminoacylation
J163_03727	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J163_03728	COG1127	ABC transporter
J163_03729	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J163_03729	COG3218	ABC-type transport auxiliary lipoprotein component
J163_03736	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J163_03737	COG0662	Cupin 2, conserved barrel domain protein
J163_03737	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
J163_03743	COG2086	electron transfer activity
J163_03746	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J163_03746	COG0546	phosphoglycolate phosphatase activity
J163_03747	COG0277	FAD linked oxidase domain protein
J163_03750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J163_03756	COG0438	transferase activity, transferring glycosyl groups
J163_03756	COG1216	Glycosyl transferase, family 2
J163_03760	COG0626	cystathionine gamma-synthase activity
J163_03766	COG0625	glutathione transferase activity
J163_03768	COG0513	Belongs to the DEAD box helicase family
J163_03771	COG4206	TonB-dependent receptor
J163_03772	COG0720	synthase
J163_03774	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
J163_03775	COG1956	GAF domain-containing protein
J163_03777	COG2819	hydrolase of the alpha beta superfamily
J163_03780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J163_03781	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J163_03784	COG0339	signal peptide processing
J163_03787	COG2132	Multicopper oxidase
J163_03795	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J163_03796	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J163_03797	COG1136	(ABC) transporter
J163_03797	COG4591	ABC-type transport system involved in lipoprotein release permease component
J163_03798	COG0577	efflux transmembrane transporter activity
J163_03798	COG1136	(ABC) transporter
J163_03799	COG0577	efflux transmembrane transporter activity
J163_03801	COG2204	response regulator
J163_03802	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J163_03805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J163_03806	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J163_03807	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J163_03808	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J163_03809	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J163_03810	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J163_03812	COG0356	it plays a direct role in the translocation of protons across the membrane
J163_03816	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J163_03818	COG0508	dehydrogenase complex catalyzes the overall conversion of
J163_03825	COG2011	ABC-type metal ion transport system permease component
J163_03826	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J163_03827	COG0697	spore germination
J163_03828	COG1666	GTP binding
J163_03830	COG5002	protein histidine kinase activity
J163_03830	COG2198	Histidine kinase
J163_03830	COG0784	Response regulator, receiver
J163_03834	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J163_03835	COG1187	pseudouridine synthase activity
J163_03836	COG2813	Specifically methylates the guanine in position
J163_03840	COG2205	protein histidine kinase activity
J163_03840	COG2202	Pas domain
J163_03844	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J163_03845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J163_03846	COG1522	sequence-specific DNA binding
J163_03856	COG0842	Transport permease protein
J163_03857	COG1131	(ABC) transporter
J163_03858	COG0025	NhaP-type Na H and K H
J163_03859	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
J163_03860	COG1573	uracil-dna glycosylase
J163_03862	COG3384	dioxygenase
J163_03864	COG0583	DNA-binding transcription factor activity
J163_03866	COG0667	Aldo Keto reductase
J163_03868	COG3590	peptidase
J163_03872	COG0531	amino acid
J163_03875	COG2972	Histidine kinase
J163_03878	COG3685	Protein conserved in bacteria
J163_03879	COG3546	catalase activity
J163_03887	COG1271	oxidase subunit
J163_03888	COG1294	oxidase, subunit
J163_03891	COG1028	Short-chain dehydrogenase reductase Sdr
J163_03892	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J163_03896	COG1132	(ABC) transporter
J163_03899	COG1063	alcohol dehydrogenase
J163_03914	COG0251	oxidation-reduction process
J163_03920	COG0840	transmembrane signaling receptor activity
J163_03924	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J163_03933	COG0024	Methionine aminopeptidase
J163_03938	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J163_03939	COG1490	D-aminoacyl-tRNA deacylase activity
J163_03940	COG1560	Kdo2-lipid A biosynthetic process
J163_03949	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J163_03949	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J163_03950	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J163_03951	COG0242	peptide deformylase activity
J163_03952	COG1652	LysM domain
J163_03953	COG0758	DNA mediated transformation
J163_03954	COG2922	Belongs to the Smg family
J163_03957	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J163_03957	COG1754	DNA topoisomerase type I activity
J163_03958	COG0009	L-threonylcarbamoyladenylate synthase
J163_03961	COG1028	Short-chain dehydrogenase reductase Sdr
J163_03963	COG0616	signal peptide processing
J163_03964	COG0534	Mate efflux family protein
J163_03968	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J163_03969	COG0625	glutathione transferase activity
J163_03972	COG1252	NADH dehydrogenase
J163_03973	COG2860	membrane
J163_03974	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J163_03975	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J163_03976	COG2201	protein-glutamate methylesterase activity
J163_03977	COG2177	Part of the ABC transporter FtsEX involved in
J163_03978	COG2884	Cell division ATP-binding protein ftsE
J163_03979	COG0513	Belongs to the DEAD box helicase family
J163_03980	COG3118	belongs to the thioredoxin family
J163_03981	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J163_03982	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
J163_03983	COG0583	DNA-binding transcription factor activity
J163_03993	COG1518	maintenance of DNA repeat elements
J163_03994	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
J163_03996	COG1652	LysM domain
J163_03997	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J163_03997	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J163_03998	COG1473	amidohydrolase
J163_03999	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J163_04000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J163_04002	COG5383	Protein conserved in bacteria
J163_04010	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
J163_04011	COG3023	N-Acetylmuramoyl-L-alanine amidase
J163_04013	COG4948	Mandelate Racemase Muconate Lactonizing
J163_04015	COG0531	amino acid
J163_04018	COG4682	membrane
J163_04019	COG2133	pyrroloquinoline quinone binding
J163_04021	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J163_04022	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J163_04023	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J163_04024	COG1610	YqeY-like protein
J163_04025	COG1295	ribonuclease BN
J163_04026	COG0358	DNA primase activity
J163_04029	COG0109	protoheme IX farnesyltransferase activity
J163_04035	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
J163_04038	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J163_04048	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J163_04049	COG0739	heme binding
J163_04050	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
J163_04052	COG2223	nitrite transmembrane transporter activity
J163_04053	COG0708	Exodeoxyribonuclease III
J163_04054	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J163_04056	COG1192	Involved in chromosome partitioning
J163_04057	COG1475	DNA binding
J163_04060	COG0463	Glycosyl transferase, family 2
J163_04064	COG0756	dUTP diphosphatase activity
J163_04065	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J163_04066	COG2003	Belongs to the UPF0758 family
J163_04067	COG0018	arginyl-trna synthetase
J163_04070	COG4221	oxidoreductase activity
J163_04071	COG2755	lipolytic protein G-D-S-L family
J163_04071	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J163_04073	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J163_04074	COG1166	arginine decarboxylase activity
J163_04075	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
J163_04082	COG0606	chelatase, subunit chli
J163_04085	COG4943	cyclic-guanylate-specific phosphodiesterase activity
J163_04094	COG1690	Belongs to the RtcB family
J163_04102	COG1090	epimerase
J163_04103	COG0745	RESPONSE REGULATOR receiver
J163_04104	COG0642	Histidine kinase
J163_04108	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J163_04113	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J163_04114	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J163_04117	COG0753	catalase activity
J163_04120	COG2197	response regulator
J163_04121	COG4585	Histidine kinase
J163_04122	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J163_04123	COG1136	(ABC) transporter
J163_04127	COG2962	Rard protein
J163_04129	COG0697	spore germination
J163_04132	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J163_04133	COG0180	Tryptophanyl-tRNA synthetase
J163_04134	COG3237	CsbD-like
J163_04142	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J163_04145	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
J163_04146	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J163_04146	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J163_04151	COG2205	protein histidine kinase activity
J163_04152	COG0745	RESPONSE REGULATOR receiver
J163_04154	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J163_04158	COG1199	ATP-dependent helicase activity
J163_04161	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J163_04172	COG0625	glutathione transferase activity
J163_04179	COG4555	ABC transporter
J163_04181	COG1476	TRANSCRIPTIONal
J163_04190	COG0633	Ferredoxin
J163_04190	COG0543	2 iron, 2 sulfur cluster binding
J163_04191	COG1131	(ABC) transporter
J163_04192	COG0842	Transport permease protein
J163_04195	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
J163_04201	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J163_04202	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J163_04204	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J163_04204	COG0045	succinate-CoA ligase (ADP-forming) activity
J163_04204	COG1042	CoA-binding domain protein
J163_04205	COG2239	Acts as a magnesium transporter
J163_04206	COG3338	carbonate dehydratase activity
J163_04208	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J163_04209	COG3387	PFAM Glycoside hydrolase 15-related
J163_04212	COG3100	YcgL domain-containing protein
J163_04213	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J163_04215	COG0463	Glycosyl transferase, family 2
J163_04218	COG1028	Short-chain dehydrogenase reductase Sdr
J163_04226	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J163_04229	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J163_04234	COG0823	Involved in the tonB-independent uptake of proteins
J163_04234	COG4946	Tricorn protease homolog
J163_04234	COG1506	peptidase
J163_04237	COG0408	coproporphyrinogen oxidase activity
J163_04244	COG0515	serine threonine protein kinase
J163_04244	COG2815	serine threonine protein kinase
J163_04245	COG0631	protein serine/threonine phosphatase activity
J163_04252	COG3501	Rhs element vgr protein
J163_04278	COG0210	DNA helicase
J163_04279	COG0210	DNA helicase
J163_04281	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J163_04282	COG0583	DNA-binding transcription factor activity
J163_04283	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J163_04285	COG2159	amidohydrolase
J163_04286	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J163_04287	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J163_04289	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J163_04293	COG0357	Ribosomal RNA small subunit methyltransferase G
J163_04294	COG3540	Alkaline phosphatase
J163_04297	COG2091	lysine biosynthetic process via aminoadipic acid
J163_04300	COG0708	Exodeoxyribonuclease III
J163_04302	COG1846	Transcriptional regulator
J163_04302	COG1940	carbohydrate kinase activity
J163_04304	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J163_04306	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J163_04307	COG3162	membrane
J163_04309	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J163_04315	COG3507	Belongs to the glycosyl hydrolase 43 family
J163_04318	COG1028	Short-chain dehydrogenase reductase Sdr
J163_04319	COG0179	Fumarylacetoacetate (FAA) hydrolase
J163_04320	COG4948	Mandelate Racemase Muconate Lactonizing
J163_04322	COG3254	rhamnose metabolic process
J163_04323	COG0738	Major facilitator superfamily
J163_04324	COG1414	Transcriptional regulator
J163_04325	COG1971	Probably functions as a manganese efflux pump
J163_04326	COG2205	protein histidine kinase activity
J163_04328	COG3459	Glycosyltransferase 36 associated
J163_04329	COG2211	Major facilitator Superfamily
J163_04330	COG3265	gluconokinase activity
J163_04331	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J163_04335	COG2911	Protein conserved in bacteria
J163_04336	COG0729	surface antigen
J163_04339	COG2963	transposase activity
J163_04340	COG2801	Transposase and inactivated derivatives
J163_04344	COG0752	glycyl-tRNA synthetase alpha subunit
J163_04345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J163_04347	COG0519	Catalyzes the synthesis of GMP from XMP
J163_04347	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J163_04349	COG0805	protein transport
J163_04350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J163_04351	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J163_04353	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J163_04356	COG2974	May be involved in recombination
J163_04357	COG0037	tRNA processing
J163_04358	COG2115	Belongs to the xylose isomerase family
J163_04360	COG3661	Belongs to the glycosyl hydrolase 67 family
J163_04362	COG4948	Mandelate Racemase Muconate Lactonizing
J163_04364	COG1472	Belongs to the glycosyl hydrolase 3 family
J163_04365	COG0246	Mannitol dehydrogenase
J163_04373	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J163_04374	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J163_04379	COG3386	PFAM SMP-30 Gluconolaconase
J163_04381	COG3250	beta-galactosidase activity
J163_04382	COG1904	glucuronate isomerase
J163_04383	COG3693	PFAM glycoside hydrolase, family 10
J163_04385	COG3693	PFAM glycoside hydrolase, family 10
J163_04388	COG2211	Major facilitator Superfamily
J163_04400	COG2937	Belongs to the GPAT DAPAT family
J163_04406	COG0284	orotidine-5'-phosphate decarboxylase activity
J163_04407	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
J163_04409	COG3132	Protein of unknown function, DUF480
J163_04412	COG0210	DNA helicase
J163_04413	COG1435	thymidine kinase activity
J163_04415	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
J163_04417	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J163_04424	COG3135	benzoate transporter
J163_04428	COG0676	glucose-6-phosphate 1-epimerase activity
J163_04430	COG3012	SEC-C Motif Domain Protein
J163_04431	COG0730	response to heat
J163_04435	COG0302	gtp cyclohydrolase
J163_04438	COG1566	PFAM secretion protein HlyD family protein
J163_04440	COG1289	transmembrane transporter activity
J163_04441	COG0477	Major facilitator Superfamily
J163_04443	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J163_04447	COG4691	Plasmid stability protein
J163_04448	COG1487	ribonuclease activity
J163_04453	COG0564	pseudouridine synthase activity
J163_04455	COG2963	transposase activity
J163_04456	COG2801	Transposase and inactivated derivatives
J163_04459	COG0439	Biotin carboxylase
J163_04470	COG1074	ATP-dependent DNA helicase activity
J163_04471	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
J163_04473	COG1127	ABC transporter
J163_04474	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J163_04475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J163_04478	COG2853	Lipoprotein
J163_04480	COG0386	Belongs to the glutathione peroxidase family
J163_04482	COG1322	Protein conserved in bacteria
J163_04483	COG0604	alcohol dehydrogenase
J163_04484	COG0583	DNA-binding transcription factor activity
J163_04486	COG0625	glutathione transferase activity
J163_04488	COG0531	amino acid
J163_04489	COG3537	Alpha-1,2-mannosidase
J163_04491	COG3706	GGDEF domain
J163_04492	COG3835	regulator
J163_04493	COG1929	Belongs to the glycerate kinase type-1 family
J163_04494	COG2271	Major facilitator Superfamily
J163_04497	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J163_04499	COG0861	Integral membrane protein TerC family
J163_04501	COG0584	glycerophosphoryl diester phosphodiesterase
J163_04504	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
J163_04505	COG0726	polysaccharide deacetylase
J163_04506	COG0706	membrane insertase activity
J163_04507	COG0594	ribonuclease P activity
J163_04508	COG0230	Belongs to the bacterial ribosomal protein bL34 family