locus-tag	class	description
HZS91_00002	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HZS91_00004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZS91_00005	COG0187	DNA topoisomerase II activity
HZS91_00007	COG0501	Belongs to the peptidase M48B family
HZS91_00013	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HZS91_00015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZS91_00024	COG0793	Belongs to the peptidase S41A family
HZS91_00025	COG4942	peptidase
HZS91_00027	COG2234	aminopeptidase activity
HZS91_00029	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZS91_00031	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZS91_00033	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZS91_00035	COG1064	alcohol dehydrogenase
HZS91_00037	COG0493	'glutamate synthase
HZS91_00038	COG0067	glutamate synthase
HZS91_00038	COG0069	glutamate synthase activity
HZS91_00038	COG0070	glutamate synthase
HZS91_00042	COG2366	antibiotic biosynthetic process
HZS91_00048	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HZS91_00051	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HZS91_00052	COG0297	glycogen (starch) synthase activity
HZS91_00052	COG0438	transferase activity, transferring glycosyl groups
HZS91_00056	COG0367	asparagine synthase
HZS91_00062	COG1132	(ABC) transporter
HZS91_00068	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HZS91_00087	COG1111	helicase
HZS91_00087	COG1205	dead DEAH box helicase
HZS91_00088	COG1272	protein, Hemolysin III
HZS91_00092	COG0300	oxidoreductase activity
HZS91_00093	COG1028	Short-chain dehydrogenase reductase Sdr
HZS91_00098	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZS91_00111	COG3237	CsbD-like
HZS91_00120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZS91_00122	COG0477	Major facilitator Superfamily
HZS91_00130	COG0714	Associated with various cellular activities
HZS91_00136	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HZS91_00138	COG4772	TonB-dependent receptor
HZS91_00140	COG0662	Cupin 2, conserved barrel domain protein
HZS91_00141	COG1012	belongs to the aldehyde dehydrogenase family
HZS91_00146	COG1304	FMN binding
HZS91_00149	COG4585	Histidine kinase
HZS91_00150	COG2197	response regulator
HZS91_00154	COG3710	Transcriptional regulator
HZS91_00155	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HZS91_00170	COG0366	Alpha amylase catalytic
HZS91_00171	COG0366	Alpha amylase catalytic
HZS91_00172	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HZS91_00176	COG2755	lipolytic protein G-D-S-L family
HZS91_00176	COG0657	acetylesterase activity
HZS91_00178	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HZS91_00181	COG3507	Belongs to the glycosyl hydrolase 43 family
HZS91_00182	COG1609	Transcriptional regulator
HZS91_00184	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HZS91_00185	COG1028	Short-chain dehydrogenase reductase Sdr
HZS91_00187	COG2755	lipolytic protein G-D-S-L family
HZS91_00190	COG3186	Phenylalanine-4-hydroxylase
HZS91_00191	COG1522	sequence-specific DNA binding
HZS91_00193	COG1752	Esterase of the alpha-beta hydrolase superfamily
HZS91_00195	COG1119	ATPase activity
HZS91_00198	COG1125	glycine betaine transport
HZS91_00201	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HZS91_00205	COG1396	sequence-specific DNA binding
HZS91_00210	COG0489	protein tyrosine kinase activity
HZS91_00211	COG2062	phosphohistidine phosphatase, SixA
HZS91_00213	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZS91_00223	COG1968	undecaprenyl-diphosphatase activity
HZS91_00225	COG0174	glutamine synthetase
HZS91_00226	COG0347	Belongs to the P(II) protein family
HZS91_00227	COG0004	ammonium transporteR
HZS91_00228	COG3852	Histidine kinase
HZS91_00229	COG2204	response regulator
HZS91_00230	COG2032	superoxide dismutase activity
HZS91_00231	COG2032	superoxide dismutase activity
HZS91_00233	COG0346	lactoylglutathione lyase activity
HZS91_00235	COG0183	Belongs to the thiolase family
HZS91_00242	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZS91_00243	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HZS91_00244	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HZS91_00247	COG0028	Belongs to the TPP enzyme family
HZS91_00248	COG2205	protein histidine kinase activity
HZS91_00253	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HZS91_00256	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZS91_00258	COG0596	Alpha beta hydrolase
HZS91_00259	COG0727	PFAM Uncharacterised protein family (UPF0153)
HZS91_00260	COG0318	PFAM AMP-dependent synthetase and ligase
HZS91_00261	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZS91_00264	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZS91_00267	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HZS91_00269	COG0564	pseudouridine synthase activity
HZS91_00274	COG0339	signal peptide processing
HZS91_00280	COG0475	glutathione-regulated potassium exporter activity
HZS91_00281	COG0583	DNA-binding transcription factor activity
HZS91_00282	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HZS91_00283	COG2224	Isocitrate lyase
HZS91_00289	COG4770	biotin carboxylase activity
HZS91_00290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZS91_00291	COG1960	acyl-CoA dehydrogenase activity
HZS91_00303	COG0523	cobalamin synthesis protein
HZS91_00305	COG0697	spore germination
HZS91_00307	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HZS91_00308	COG1846	Transcriptional regulator
HZS91_00309	COG1764	response to oxidative stress
HZS91_00315	COG2130	NADP-dependent
HZS91_00318	COG1187	pseudouridine synthase activity
HZS91_00321	COG1643	Atp-dependent helicase
HZS91_00323	COG4807	Protein conserved in bacteria
HZS91_00324	COG2351	hydroxyisourate hydrolase activity
HZS91_00325	COG2072	flavoprotein involved in K transport
HZS91_00329	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HZS91_00336	COG1957	nucleoside hydrolase
HZS91_00338	COG2252	PERMEase
HZS91_00343	COG0084	hydrolase, TatD family'
HZS91_00346	COG0583	DNA-binding transcription factor activity
HZS91_00347	COG2814	Major facilitator Superfamily
HZS91_00350	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HZS91_00351	COG1902	pentaerythritol trinitrate reductase activity
HZS91_00355	COG0745	RESPONSE REGULATOR receiver
HZS91_00356	COG2205	protein histidine kinase activity
HZS91_00357	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS91_00361	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HZS91_00362	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HZS91_00363	COG0583	DNA-binding transcription factor activity
HZS91_00370	COG0702	epimerase
HZS91_00371	COG1733	regulation of RNA biosynthetic process
HZS91_00378	COG0129	dihydroxy-acid dehydratase activity
HZS91_00381	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HZS91_00394	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HZS91_00395	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HZS91_00400	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HZS91_00401	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HZS91_00403	COG3485	protocatechuate 3,4-dioxygenase
HZS91_00404	COG3485	protocatechuate 3,4-dioxygenase
HZS91_00406	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZS91_00407	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZS91_00410	COG1414	Transcriptional regulator
HZS91_00412	COG0657	acetylesterase activity
HZS91_00414	COG0445	tRNA wobble uridine modification
HZS91_00416	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZS91_00422	COG2267	carboxylic ester hydrolase activity
HZS91_00424	COG0156	8-amino-7-oxononanoate synthase activity
HZS91_00425	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZS91_00426	COG1040	competence protein
HZS91_00427	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HZS91_00445	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZS91_00459	COG3264	Mechanosensitive ion channel
HZS91_00459	COG1511	domain protein
HZS91_00460	COG1368	sulfuric ester hydrolase activity
HZS91_00462	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HZS91_00463	COG2354	Protein conserved in bacteria
HZS91_00465	COG0297	glycogen (starch) synthase activity
HZS91_00466	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HZS91_00467	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HZS91_00472	COG0702	epimerase
HZS91_00473	COG1028	Short-chain dehydrogenase reductase Sdr
HZS91_00480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZS91_00481	COG1028	Short-chain dehydrogenase reductase Sdr
HZS91_00484	COG0513	Belongs to the DEAD box helicase family
HZS91_00488	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HZS91_00490	COG3483	tryptophan 2,3-dioxygenase activity
HZS91_00491	COG3104	oligopeptide transport
HZS91_00495	COG2852	Protein conserved in bacteria
HZS91_00496	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HZS91_00500	COG1320	monovalent cation:proton antiporter activity
HZS91_00501	COG2212	antiporter activity
HZS91_00503	COG0651	ATP synthesis coupled electron transport
HZS91_00504	COG1006	Multisubunit Na H antiporter MnhC subunit
HZS91_00505	COG2111	Na H antiporter
HZS91_00505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HZS91_00511	COG3179	chitinase
HZS91_00515	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HZS91_00516	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HZS91_00519	COG0456	acetyltransferase
HZS91_00520	COG1597	lipid kinase activity
HZS91_00524	COG0582	viral genome integration into host DNA
HZS91_00525	COG0659	secondary active sulfate transmembrane transporter activity
HZS91_00526	COG5002	protein histidine kinase activity
HZS91_00527	COG0745	RESPONSE REGULATOR receiver
HZS91_00533	COG3039	Transposase
HZS91_00539	COG2003	Belongs to the UPF0758 family
HZS91_00556	COG0270	DNA (cytosine-5-)-methyltransferase activity
HZS91_00570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZS91_00571	COG0134	indole-3-glycerol-phosphate synthase activity
HZS91_00573	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZS91_00574	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HZS91_00576	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HZS91_00578	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HZS91_00581	COG1051	belongs to the nudix hydrolase family
HZS91_00589	COG0316	Belongs to the HesB IscA family
HZS91_00594	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HZS91_00597	COG2814	Major facilitator Superfamily
HZS91_00598	COG0583	DNA-binding transcription factor activity
HZS91_00599	COG2814	Major facilitator Superfamily
HZS91_00600	COG1289	transmembrane transporter activity
HZS91_00602	COG0151	Belongs to the GarS family
HZS91_00604	COG0138	bifunctional purine biosynthesis protein purh
HZS91_00605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZS91_00606	COG2267	carboxylic ester hydrolase activity
HZS91_00607	COG0671	phosphoesterase, PA-phosphatase related
HZS91_00607	COG2453	phosphatase
HZS91_00612	COG4589	Belongs to the CDS family
HZS91_00613	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HZS91_00618	COG2264	protein methyltransferase activity
HZS91_00623	COG0439	Biotin carboxylase
HZS91_00625	COG0511	ligase activity, forming carbon-carbon bonds
HZS91_00626	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HZS91_00628	COG1324	tolerance protein
HZS91_00634	COG0300	oxidoreductase activity
HZS91_00635	COG2356	endonuclease I
HZS91_00638	COG0459	protein refolding
HZS91_00641	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HZS91_00644	COG3386	PFAM SMP-30 Gluconolaconase
HZS91_00646	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HZS91_00647	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HZS91_00651	COG0778	Nitroreductase
HZS91_00652	COG2353	YceI-like domain
HZS91_00658	COG3052	prosthetic group binding
HZS91_00663	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HZS91_00665	COG1802	Transcriptional regulator
HZS91_00677	COG4221	oxidoreductase activity
HZS91_00680	COG4221	oxidoreductase activity
HZS91_00682	COG0435	Glutathione S-transferase
HZS91_00687	COG2409	Drug exporters of the RND superfamily
HZS91_00689	COG1506	peptidase
HZS91_00689	COG0823	Involved in the tonB-independent uptake of proteins
HZS91_00696	COG0697	spore germination
HZS91_00699	COG1113	amino acid transport
HZS91_00703	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HZS91_00712	COG5001	Diguanylate cyclase
HZS91_00713	COG0840	transmembrane signaling receptor activity
HZS91_00714	COG5297	Belongs to the glycosyl hydrolase family 6
HZS91_00714	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZS91_00715	COG0659	secondary active sulfate transmembrane transporter activity
HZS91_00720	COG2943	transferase activity, transferring hexosyl groups
HZS91_00722	COG3275	phosphorelay sensor kinase activity
HZS91_00724	COG0181	hydroxymethylbilane synthase activity
HZS91_00730	COG1505	serine-type exopeptidase activity
HZS91_00731	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HZS91_00732	COG0436	Aminotransferase
HZS91_00735	COG2832	Protein of unknown function (DUF454)
HZS91_00737	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HZS91_00739	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HZS91_00740	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HZS91_00741	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HZS91_00746	COG2226	methyltransferase
HZS91_00747	COG5001	Diguanylate cyclase
HZS91_00747	COG3300	MHYT domain
HZS91_00748	COG0308	aminopeptidase N
HZS91_00758	COG3284	Transcriptional regulator
HZS91_00759	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZS91_00760	COG1077	Cell shape determining protein MreB Mrl
HZS91_00761	COG1792	Involved in formation and maintenance of cell shape
HZS91_00764	COG0772	Belongs to the SEDS family
HZS91_00766	COG2951	lytic endotransglycosylase activity
HZS91_00767	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HZS91_00769	COG1686	Belongs to the peptidase S11 family
HZS91_00771	COG2921	Belongs to the UPF0250 family
HZS91_00772	COG0321	lipoyl(octanoyl) transferase activity
HZS91_00773	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HZS91_00776	COG0583	DNA-binding transcription factor activity
HZS91_00778	COG1051	belongs to the nudix hydrolase family
HZS91_00778	COG1056	cytidyltransferase-related domain
HZS91_00785	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HZS91_00786	COG0673	inositol 2-dehydrogenase activity
HZS91_00787	COG2823	Periplasmic or secreted lipoprotein
HZS91_00788	COG4251	negative regulation of phosphorylation
HZS91_00789	COG0784	Response regulator, receiver
HZS91_00790	COG4191	Histidine kinase
HZS91_00791	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HZS91_00803	COG1459	type II secretion system
HZS91_00813	COG3250	beta-galactosidase activity
HZS91_00816	COG2188	Transcriptional regulator
HZS91_00818	COG1609	Transcriptional regulator
HZS91_00819	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZS91_00820	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HZS91_00822	COG0617	tRNA 3'-terminal CCA addition
HZS91_00823	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HZS91_00824	COG1012	belongs to the aldehyde dehydrogenase family
HZS91_00825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HZS91_00828	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HZS91_00831	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HZS91_00832	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HZS91_00836	COG2205	protein histidine kinase activity
HZS91_00842	COG3791	Glutathione-dependent formaldehyde-activating
HZS91_00845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZS91_00847	COG0697	spore germination
HZS91_00849	COG0488	(ABC) transporter
HZS91_00851	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZS91_00852	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HZS91_00854	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZS91_00854	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZS91_00858	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HZS91_00859	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZS91_00860	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HZS91_00865	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HZS91_00866	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HZS91_00867	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HZS91_00868	COG2205	protein histidine kinase activity
HZS91_00869	COG0745	RESPONSE REGULATOR receiver
HZS91_00872	COG0277	FAD linked oxidase domain protein
HZS91_00873	COG1988	membrane-bound metal-dependent
HZS91_00874	COG0792	nuclease activity
HZS91_00881	COG0275	rRNA processing
HZS91_00882	COG3116	cell division
HZS91_00884	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZS91_00885	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HZS91_00886	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZS91_00888	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZS91_00889	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZS91_00890	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZS91_00891	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HZS91_00894	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HZS91_00896	COG0739	heme binding
HZS91_00897	COG0653	protein targeting
HZS91_00898	COG0494	nUDIX hydrolase
HZS91_00900	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HZS91_00903	COG0604	alcohol dehydrogenase
HZS91_00903	COG1028	Short-chain dehydrogenase reductase Sdr
HZS91_00903	COG3321	synthase
HZS91_00909	COG0366	Alpha amylase catalytic
HZS91_00915	COG2226	methyltransferase
HZS91_00916	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HZS91_00919	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HZS91_00929	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HZS91_00931	COG4106	trans-aconitate 2-methyltransferase activity
HZS91_00932	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZS91_00934	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZS91_00935	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HZS91_00937	COG0667	Aldo Keto reductase
HZS91_00939	COG4771	TonB-dependent receptor
HZS91_00943	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZS91_00944	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HZS91_00946	COG2175	clavaminate synthase activity
HZS91_00948	COG4181	ATPase activity
HZS91_00951	COG0642	Histidine kinase
HZS91_00954	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HZS91_00958	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HZS91_00959	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HZS91_00962	COG3829	transcription factor binding
HZS91_00964	COG1116	anion transmembrane transporter activity
HZS91_00965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZS91_00967	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZS91_00968	COG0431	NADPH-dependent FMN reductase
HZS91_00973	COG0747	negative chemotaxis
HZS91_00975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZS91_00977	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HZS91_00978	COG2967	ApaG domain
HZS91_00979	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HZS91_00980	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HZS91_00981	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZS91_00982	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HZS91_00985	COG0123	including yeast histone deacetylase and acetoin utilization protein
HZS91_00986	COG2096	Adenosyltransferase
HZS91_00989	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZS91_00990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZS91_00996	COG3384	dioxygenase
HZS91_00997	COG0583	DNA-binding transcription factor activity
HZS91_01000	COG1024	Enoyl-CoA hydratase
HZS91_01004	COG3386	PFAM SMP-30 Gluconolaconase
HZS91_01007	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HZS91_01011	COG0697	spore germination
HZS91_01013	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZS91_01017	COG0784	Response regulator, receiver
HZS91_01017	COG2205	protein histidine kinase activity
HZS91_01017	COG5002	protein histidine kinase activity
HZS91_01018	COG2197	response regulator
HZS91_01020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZS91_01022	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZS91_01023	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZS91_01025	COG0583	DNA-binding transcription factor activity
HZS91_01026	COG3634	alkyl hydroperoxide reductase activity
HZS91_01028	COG2890	protein-(glutamine-N5) methyltransferase activity
HZS91_01032	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZS91_01032	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZS91_01038	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HZS91_01044	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HZS91_01047	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZS91_01048	COG1404	Belongs to the peptidase S8 family
HZS91_01049	COG1404	Belongs to the peptidase S8 family
HZS91_01050	COG1404	Belongs to the peptidase S8 family
HZS91_01051	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HZS91_01053	COG5520	Belongs to the glycosyl hydrolase 30 family
HZS91_01056	COG1295	ribonuclease BN
HZS91_01057	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZS91_01058	COG1254	Belongs to the acylphosphatase family
HZS91_01061	COG0521	Mo-molybdopterin cofactor biosynthetic process
HZS91_01063	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HZS91_01064	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HZS91_01066	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HZS91_01067	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HZS91_01069	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HZS91_01070	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HZS91_01071	COG0193	aminoacyl-tRNA hydrolase activity
HZS91_01072	COG0012	GTP binding
HZS91_01076	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZS91_01079	COG0250	Participates in transcription elongation, termination and antitermination
HZS91_01080	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HZS91_01081	COG0081	regulation of translation
HZS91_01082	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HZS91_01083	COG0222	ribosome binding
HZS91_01084	COG0085	RNA polymerase activity
HZS91_01085	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HZS91_01086	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HZS91_01087	COG0049	tRNA binding
HZS91_01088	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HZS91_01089	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZS91_01090	COG0051	transcription antitermination factor activity, RNA binding
HZS91_01091	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HZS91_01092	COG0088	Forms part of the polypeptide exit tunnel
HZS91_01093	COG0089	rRNA binding
HZS91_01094	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HZS91_01095	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HZS91_01097	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HZS91_01098	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HZS91_01099	COG0255	Belongs to the universal ribosomal protein uL29 family
HZS91_01100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HZS91_01102	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HZS91_01103	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HZS91_01105	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HZS91_01106	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HZS91_01107	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HZS91_01109	COG1841	ribosomal large subunit assembly
HZS91_01110	COG0200	Binds to the 23S rRNA
HZS91_01111	COG0201	protein transport
HZS91_01116	COG0203	ribosomal protein L17
HZS91_01117	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HZS91_01121	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HZS91_01123	COG0154	amidase activity
HZS91_01125	COG1217	gtp-binding protein TYPA
HZS91_01126	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZS91_01127	COG0039	L-malate dehydrogenase activity
HZS91_01128	COG0625	glutathione transferase activity
HZS91_01132	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZS91_01132	COG1902	pentaerythritol trinitrate reductase activity
HZS91_01133	COG0604	alcohol dehydrogenase
HZS91_01139	COG0156	8-amino-7-oxononanoate synthase activity
HZS91_01140	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HZS91_01141	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HZS91_01142	COG4208	sulfate ABC transporter
HZS91_01143	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HZS91_01145	COG1063	alcohol dehydrogenase
HZS91_01151	COG0406	alpha-ribazole phosphatase activity
HZS91_01152	COG0285	dihydrofolate synthase activity
HZS91_01156	COG2833	Protein of unknown function (DUF455)
HZS91_01158	COG3291	Pkd domain containing protein
HZS91_01160	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZS91_01161	COG0671	phosphoesterase, PA-phosphatase related
HZS91_01162	COG0438	transferase activity, transferring glycosyl groups
HZS91_01164	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HZS91_01167	COG4783	chaperone-mediated protein folding
HZS91_01170	COG0473	3-isopropylmalate dehydrogenase activity
HZS91_01178	COG2963	transposase activity
HZS91_01198	COG3852	Histidine kinase
HZS91_01200	COG0544	peptidyl-prolyl cis-trans isomerase activity
HZS91_01202	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HZS91_01208	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZS91_01210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZS91_01212	COG0328	RNA-DNA hybrid ribonuclease activity
HZS91_01213	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HZS91_01214	COG0631	protein serine/threonine phosphatase activity
HZS91_01217	COG0859	PFAM glycosyl transferase family 9
HZS91_01218	COG3642	lipopolysaccharide core region biosynthetic process
HZS91_01219	COG1234	tRNA 3'-trailer cleavage
HZS91_01220	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HZS91_01222	COG0315	cyclic pyranopterin monophosphate synthase activity
HZS91_01223	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HZS91_01224	COG0314	molybdopterin synthase activity
HZS91_01235	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HZS91_01236	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HZS91_01237	COG0537	adenosine 5'-monophosphoramidase activity
HZS91_01241	COG0714	Associated with various cellular activities
HZS91_01246	COG0424	maF-like protein
HZS91_01247	COG1399	metal-binding, possibly nucleic acid-binding protein
HZS91_01248	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HZS91_01249	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZS91_01252	COG1028	Short-chain dehydrogenase reductase Sdr
HZS91_01255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HZS91_01256	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HZS91_01262	COG3829	transcription factor binding
HZS91_01266	COG3609	addiction module antidote protein, CC2985 family
HZS91_01273	COG2373	Large extracellular alpha-helical protein
HZS91_01277	COG4953	penicillin-binding protein 1C
HZS91_01279	COG0678	peroxiredoxin activity
HZS91_01283	COG0330	HflC and HflK could
HZS91_01284	COG0330	HflC and HflK could
HZS91_01286	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HZS91_01287	COG0308	aminopeptidase N
HZS91_01288	COG1028	Short-chain dehydrogenase reductase Sdr
HZS91_01289	COG1309	transcriptional regulator
HZS91_01298	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HZS91_01305	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HZS91_01307	COG3387	PFAM Glycoside hydrolase 15-related
HZS91_01308	COG1028	Short-chain dehydrogenase reductase Sdr
HZS91_01310	COG3537	Alpha-1,2-mannosidase
HZS91_01314	COG0492	ferredoxin-NADP+ reductase activity
HZS91_01319	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZS91_01320	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HZS91_01321	COG2080	2 iron, 2 sulfur cluster binding
HZS91_01328	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HZS91_01331	COG0587	DNA-directed DNA polymerase activity
HZS91_01335	COG1297	OPT oligopeptide transporter protein
HZS91_01338	COG0823	Involved in the tonB-independent uptake of proteins
HZS91_01338	COG1506	peptidase
HZS91_01341	COG2207	Transcriptional regulator
HZS91_01341	COG1917	Cupin 2, conserved barrel domain protein
HZS91_01345	COG0753	catalase activity
HZS91_01346	COG0656	L-ascorbic acid biosynthetic process
HZS91_01348	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZS91_01348	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZS91_01349	COG2814	Major facilitator Superfamily
HZS91_01352	COG2194	sulfuric ester hydrolase activity
HZS91_01355	COG0745	RESPONSE REGULATOR receiver
HZS91_01356	COG0642	Histidine kinase
HZS91_01358	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HZS91_01359	COG2894	cell division
HZS91_01360	COG0850	regulation of cytokinetic process
HZS91_01363	COG4585	Histidine kinase
HZS91_01364	COG2197	response regulator
HZS91_01367	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HZS91_01373	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HZS91_01375	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HZS91_01379	COG1946	Acyl-CoA thioesterase
HZS91_01382	COG0824	Thioesterase
HZS91_01383	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZS91_01384	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HZS91_01385	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HZS91_01386	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HZS91_01387	COG0268	Binds directly to 16S ribosomal RNA
HZS91_01389	COG0196	riboflavin kinase activity
HZS91_01390	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HZS91_01391	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HZS91_01392	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HZS91_01395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZS91_01396	COG1845	cytochrome c oxidase, subunit III
HZS91_01397	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HZS91_01400	COG3152	Membrane
HZS91_01402	COG2207	Transcriptional regulator
HZS91_01403	COG0326	Molecular chaperone. Has ATPase activity
HZS91_01405	COG1366	Belongs to the anti-sigma-factor antagonist family
HZS91_01406	COG1366	Belongs to the anti-sigma-factor antagonist family
HZS91_01407	COG2172	sigma factor antagonist activity
HZS91_01412	COG4771	TonB-dependent receptor
HZS91_01414	COG5507	3-demethylubiquinone-9 3-methyltransferase
HZS91_01415	COG2205	protein histidine kinase activity
HZS91_01417	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HZS91_01418	COG2205	protein histidine kinase activity
HZS91_01418	COG3437	response regulator, receiver
HZS91_01418	COG3850	Histidine kinase
HZS91_01418	COG4999	Histidine kinase
HZS91_01419	COG4191	Histidine kinase
HZS91_01419	COG0784	Response regulator, receiver
HZS91_01424	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZS91_01426	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HZS91_01429	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZS91_01430	COG0228	four-way junction DNA binding
HZS91_01431	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HZS91_01432	COG0336	Belongs to the RNA methyltransferase TrmD family
HZS91_01433	COG0335	large ribosomal subunit rRNA binding
HZS91_01434	COG0534	Mate efflux family protein
HZS91_01438	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HZS91_01440	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HZS91_01442	COG3209	COG3209 Rhs family protein
HZS91_01447	COG3250	beta-galactosidase activity
HZS91_01448	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HZS91_01452	COG1960	acyl-CoA dehydrogenase activity
HZS91_01453	COG1024	Enoyl-CoA hydratase
HZS91_01457	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZS91_01457	COG1024	Enoyl-CoA hydratase
HZS91_01460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZS91_01461	COG0481	GTPase activity
HZS91_01464	COG0571	ribonuclease III activity
HZS91_01465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HZS91_01466	COG1381	Involved in DNA repair and RecF pathway recombination
HZS91_01468	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZS91_01469	COG2954	triphosphatase activity
HZS91_01470	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HZS91_01471	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HZS91_01472	COG3046	protein related to deoxyribodipyrimidine photolyase
HZS91_01473	COG1472	Belongs to the glycosyl hydrolase 3 family
HZS91_01474	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HZS91_01475	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HZS91_01476	COG1278	Cold shock
HZS91_01477	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZS91_01479	COG1201	RNA secondary structure unwinding
HZS91_01480	COG1793	dna ligase
HZS91_01482	COG1793	dna ligase
HZS91_01482	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HZS91_01488	COG0183	Belongs to the thiolase family
HZS91_01493	COG1451	nucleotide metabolic process
HZS91_01494	COG5487	UPF0391 membrane protein
HZS91_01496	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HZS91_01499	COG1077	Cell shape determining protein MreB Mrl
HZS91_01500	COG1047	Peptidyl-prolyl cis-trans
HZS91_01502	COG2824	Alkylphosphonate utilization operon protein PhnA
HZS91_01504	COG1902	pentaerythritol trinitrate reductase activity
HZS91_01505	COG2814	Major facilitator Superfamily
HZS91_01511	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HZS91_01511	COG0392	lysyltransferase activity
HZS91_01513	COG0251	oxidation-reduction process
HZS91_01514	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZS91_01517	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZS91_01522	COG1595	DNA-templated transcription, initiation
HZS91_01526	COG2878	Part of a membrane complex involved in electron transport
HZS91_01528	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZS91_01528	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZS91_01531	COG1131	(ABC) transporter
HZS91_01532	COG0346	lactoylglutathione lyase activity
HZS91_01533	COG0833	amino acid
HZS91_01534	COG2040	homocysteine
HZS91_01536	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HZS91_01540	COG1695	Transcriptional regulator
HZS91_01544	COG1981	membrane
HZS91_01547	COG0825	malonyl-CoA metabolic process
HZS91_01549	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HZS91_01550	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZS91_01551	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZS91_01552	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZS91_01553	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZS91_01556	COG0750	zinc metalloprotease
HZS91_01557	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HZS91_01558	COG0575	Belongs to the CDS family
HZS91_01559	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HZS91_01560	COG0233	cytoplasmic translational termination
HZS91_01561	COG0528	UMP kinase activity
HZS91_01563	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HZS91_01564	COG0052	Belongs to the universal ribosomal protein uS2 family
HZS91_01572	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HZS91_01574	COG1393	Belongs to the ArsC family
HZS91_01575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZS91_01576	COG0367	asparagine synthase
HZS91_01578	COG4774	siderophore transport
HZS91_01581	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZS91_01588	COG1566	PFAM secretion protein HlyD family protein
HZS91_01589	COG2814	Major facilitator Superfamily
HZS91_01599	COG0339	signal peptide processing
HZS91_01601	COG0386	Belongs to the glutathione peroxidase family
HZS91_01612	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HZS91_01613	COG0084	hydrolase, TatD family'
HZS91_01616	COG1960	acyl-CoA dehydrogenase activity
HZS91_01620	COG0367	asparagine synthase
HZS91_01622	COG0305	Participates in initiation and elongation during chromosome replication
HZS91_01623	COG0415	Belongs to the DNA photolyase family
HZS91_01627	COG0583	DNA-binding transcription factor activity
HZS91_01636	COG3706	GGDEF domain
HZS91_01660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HZS91_01663	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZS91_01665	COG0497	DNA recombination
HZS91_01666	COG1420	regulation of RNA biosynthetic process
HZS91_01667	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HZS91_01668	COG0443	Heat shock 70 kDa protein
HZS91_01669	COG0484	heat shock protein binding
HZS91_01671	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HZS91_01677	COG0583	DNA-binding transcription factor activity
HZS91_01678	COG1132	(ABC) transporter
HZS91_01685	COG2850	peptidyl-arginine hydroxylation
HZS91_01689	COG1253	flavin adenine dinucleotide binding
HZS91_01695	COG1131	(ABC) transporter
HZS91_01696	COG1725	Transcriptional regulator
HZS91_01698	COG0386	Belongs to the glutathione peroxidase family
HZS91_01701	COG2900	Belongs to the SlyX family
HZS91_01706	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZS91_01708	COG0646	methionine synthase
HZS91_01708	COG1410	methionine synthase
HZS91_01709	COG0646	methionine synthase
HZS91_01709	COG1410	methionine synthase
HZS91_01710	COG2226	methyltransferase
HZS91_01711	COG1960	acyl-CoA dehydrogenase activity
HZS91_01715	COG0557	exoribonuclease II activity
HZS91_01717	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZS91_01719	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HZS91_01721	COG0704	Plays a role in the regulation of phosphate uptake
HZS91_01722	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZS91_01723	COG0581	inorganic phosphate transmembrane transporter activity
HZS91_01724	COG0573	inorganic phosphate transmembrane transporter activity
HZS91_01725	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HZS91_01730	COG0659	secondary active sulfate transmembrane transporter activity
HZS91_01731	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HZS91_01733	COG1024	Enoyl-CoA hydratase
HZS91_01735	COG0494	nUDIX hydrolase
HZS91_01742	COG0488	(ABC) transporter
HZS91_01744	COG0116	Belongs to the methyltransferase superfamily
HZS91_01744	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HZS91_01745	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZS91_01750	COG2925	Exonuclease
HZS91_01752	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZS91_01753	COG3844	kynureninase activity
HZS91_01755	COG0662	Cupin 2, conserved barrel domain protein
HZS91_01756	COG0288	reversible hydration of carbon dioxide
HZS91_01769	COG2808	Putative FMN-binding domain
HZS91_01773	COG0017	Asparaginyl-tRNA synthetase
HZS91_01775	COG0316	Belongs to the HesB IscA family
HZS91_01776	COG0360	Binds together with S18 to 16S ribosomal RNA
HZS91_01777	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HZS91_01778	COG0359	binds to the 23S rRNA
HZS91_01780	COG3115	cell septum assembly
HZS91_01782	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZS91_01783	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HZS91_01784	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HZS91_01787	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HZS91_01789	COG4993	Dehydrogenase
HZS91_01791	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HZS91_01793	COG2986	histidine ammonia-lyase
HZS91_01794	COG1228	amidohydrolase
HZS91_01804	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HZS91_01805	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HZS91_01806	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HZS91_01807	COG1605	Chorismate mutase
HZS91_01807	COG0077	Prephenate dehydratase
HZS91_01808	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HZS91_01811	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HZS91_01812	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HZS91_01813	COG0583	DNA-binding transcription factor activity
HZS91_01816	COG0840	transmembrane signaling receptor activity
HZS91_01823	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HZS91_01824	COG4191	Histidine kinase
HZS91_01824	COG0784	Response regulator, receiver
HZS91_01827	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZS91_01829	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HZS91_01831	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZS91_01834	COG1595	DNA-templated transcription, initiation
HZS91_01845	COG2244	polysaccharide biosynthetic process
HZS91_01852	COG2264	protein methyltransferase activity
HZS91_01854	COG0438	transferase activity, transferring glycosyl groups
HZS91_01857	COG1136	(ABC) transporter
HZS91_01859	COG0477	Major facilitator Superfamily
HZS91_01860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZS91_01863	COG1253	flavin adenine dinucleotide binding
HZS91_01866	COG0306	phosphate transporter
HZS91_01872	COG0504	CTP synthase activity
HZS91_01873	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HZS91_01875	COG0148	phosphopyruvate hydratase activity
HZS91_01876	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HZS91_01877	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HZS91_01878	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HZS91_01879	COG0585	pseudouridine synthase activity
HZS91_01880	COG2840	Smr protein MutS2
HZS91_01881	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HZS91_01882	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HZS91_01883	COG1238	metal cluster binding
HZS91_01886	COG1534	Rna-binding protein
HZS91_01887	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HZS91_01889	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HZS91_01890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HZS91_01892	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HZS91_01893	COG1546	Belongs to the CinA family
HZS91_01895	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HZS91_01896	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HZS91_01898	COG2137	regulation of response to DNA damage stimulus
HZS91_01899	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HZS91_01900	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HZS91_01904	COG1741	Belongs to the pirin family
HZS91_01905	COG0583	DNA-binding transcription factor activity
HZS91_01910	COG0352	thiamine-phosphate diphosphorylase activity
HZS91_01910	COG0351	phosphomethylpyrimidine kinase
HZS91_01913	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HZS91_01914	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HZS91_01917	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZS91_01919	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HZS91_01920	COG3734	2-keto-3-deoxy-galactonokinase
HZS91_01922	COG4948	Mandelate Racemase Muconate Lactonizing
HZS91_01923	COG0800	Aldolase
HZS91_01931	COG1501	Belongs to the glycosyl hydrolase 31 family
HZS91_01933	COG1070	Carbohydrate kinase
HZS91_01934	COG2115	Belongs to the xylose isomerase family
HZS91_01935	COG0477	Major facilitator Superfamily
HZS91_01939	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZS91_01940	COG1469	GTP cyclohydrolase I activity
HZS91_01944	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HZS91_01945	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HZS91_01946	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HZS91_01947	COG0166	Belongs to the GPI family
HZS91_01952	COG1472	Belongs to the glycosyl hydrolase 3 family
HZS91_01955	COG3706	GGDEF domain
HZS91_01955	COG5001	Diguanylate cyclase
HZS91_01955	COG2203	Gaf domain
HZS91_01955	COG4251	negative regulation of phosphorylation
HZS91_01956	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZS91_01957	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HZS91_01959	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HZS91_01960	COG0671	phosphoesterase, PA-phosphatase related
HZS91_01963	COG1794	racemase activity, acting on amino acids and derivatives
HZS91_01965	COG0697	spore germination
HZS91_01966	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HZS91_01967	COG0167	dihydroorotate dehydrogenase activity
HZS91_01971	COG1012	belongs to the aldehyde dehydrogenase family
HZS91_01974	COG1215	transferase activity, transferring glycosyl groups
HZS91_01975	COG1649	PFAM Uncharacterised BCR, COG1649
HZS91_01975	COG0726	polysaccharide deacetylase
HZS91_01978	COG3210	domain, Protein
HZS91_01980	COG3210	domain, Protein
HZS91_01991	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZS91_01992	COG0124	histidyl-tRNA synthetase
HZS91_01994	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HZS91_01995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HZS91_01996	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZS91_01997	COG0131	Imidazoleglycerol-phosphate dehydratase
HZS91_01997	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HZS91_01998	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HZS91_01999	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HZS91_02000	COG0107	imidazoleglycerol-phosphate synthase activity
HZS91_02001	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HZS91_02001	COG0140	phosphoribosyl-ATP diphosphatase activity
HZS91_02004	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HZS91_02005	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HZS91_02006	COG0235	Class ii aldolase
HZS91_02007	COG0531	amino acid
HZS91_02008	COG0531	amino acid
HZS91_02010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZS91_02011	COG0277	FAD linked oxidase domain protein
HZS91_02015	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HZS91_02024	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZS91_02025	COG2258	MOSC domain
HZS91_02026	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HZS91_02027	COG0505	Belongs to the CarA family
HZS91_02029	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HZS91_02030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZS91_02032	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HZS91_02040	COG3279	Response regulator of the LytR AlgR family
HZS91_02041	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HZS91_02042	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HZS91_02044	COG2198	Histidine kinase
HZS91_02044	COG0784	Response regulator, receiver
HZS91_02044	COG2205	protein histidine kinase activity
HZS91_02045	COG1024	Enoyl-CoA hydratase
HZS91_02046	COG0318	PFAM AMP-dependent synthetase and ligase
HZS91_02052	COG2267	carboxylic ester hydrolase activity
HZS91_02054	COG2201	protein-glutamate methylesterase activity
HZS91_02055	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HZS91_02057	COG0840	transmembrane signaling receptor activity
HZS91_02059	COG0835	chemotaxis
HZS91_02062	COG0840	transmembrane signaling receptor activity
HZS91_02063	COG0840	transmembrane signaling receptor activity
HZS91_02064	COG0840	transmembrane signaling receptor activity
HZS91_02065	COG0840	transmembrane signaling receptor activity
HZS91_02066	COG0840	transmembrane signaling receptor activity
HZS91_02068	COG0840	transmembrane signaling receptor activity
HZS91_02069	COG0840	transmembrane signaling receptor activity
HZS91_02070	COG0840	transmembrane signaling receptor activity
HZS91_02071	COG0840	transmembrane signaling receptor activity
HZS91_02074	COG0840	transmembrane signaling receptor activity
HZS91_02077	COG0840	transmembrane signaling receptor activity
HZS91_02078	COG0643	Histidine kinase
HZS91_02078	COG2198	Histidine kinase
HZS91_02079	COG0745	RESPONSE REGULATOR receiver
HZS91_02081	COG0835	chemotaxis
HZS91_02083	COG1360	Flagellar Motor Protein
HZS91_02084	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HZS91_02100	COG2963	transposase activity
HZS91_02106	COG0641	radical SAM
HZS91_02110	COG0643	Histidine kinase
HZS91_02110	COG0784	Response regulator, receiver
HZS91_02110	COG2198	Histidine kinase
HZS91_02116	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZS91_02122	COG1684	flagellar biosynthetic protein fliR
HZS91_02126	COG3190	flagellar
HZS91_02136	COG1677	Flagellar hook-basal body complex protein FliE
HZS91_02142	COG1028	Short-chain dehydrogenase reductase Sdr
HZS91_02143	COG1028	Short-chain dehydrogenase reductase Sdr
HZS91_02144	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZS91_02148	COG2201	protein-glutamate methylesterase activity
HZS91_02154	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HZS91_02156	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZS91_02157	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZS91_02159	COG3951	Flagellar rod assembly protein muramidase FlgJ
HZS91_02159	COG1705	Flagellar rod assembly protein muramidase FlgJ
HZS91_02160	COG1706	bacterial-type flagellum-dependent cell motility
HZS91_02161	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HZS91_02163	COG4787	bacterial-type flagellum-dependent cell motility
HZS91_02165	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HZS91_02166	COG1558	bacterial-type flagellum-dependent cell motility
HZS91_02168	COG0784	Response regulator, receiver
HZS91_02168	COG0835	chemotaxis
HZS91_02172	COG5002	protein histidine kinase activity
HZS91_02178	COG2915	High frequency lysogenization protein hflD homolog
HZS91_02179	COG0482	sulfurtransferase activity
HZS91_02182	COG0542	response to heat
HZS91_02184	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HZS91_02186	COG0492	ferredoxin-NADP+ reductase activity
HZS91_02187	COG1674	ftsk spoiiie
HZS91_02189	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HZS91_02191	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HZS91_02192	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HZS91_02194	COG0183	Belongs to the thiolase family
HZS91_02195	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZS91_02195	COG1024	Enoyl-CoA hydratase
HZS91_02198	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HZS91_02200	COG1426	Protein conserved in bacteria
HZS91_02202	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZS91_02203	COG1160	GTP binding
HZS91_02204	COG0303	'Molybdopterin
HZS91_02205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HZS91_02213	COG0708	Exodeoxyribonuclease III
HZS91_02215	COG0303	'Molybdopterin
HZS91_02216	COG0746	molybdenum cofactor guanylyltransferase activity
HZS91_02219	COG1914	H( )-stimulated, divalent metal cation uptake system
HZS91_02222	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HZS91_02223	COG0668	transmembrane transport
HZS91_02225	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HZS91_02228	COG1028	Short-chain dehydrogenase reductase Sdr
HZS91_02229	COG1183	phosphatidylcholine synthase activity
HZS91_02231	COG3243	poly(R)-hydroxyalkanoic acid synthase
HZS91_02234	COG0723	plastoquinol--plastocyanin reductase activity
HZS91_02234	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZS91_02236	COG2183	response to ionizing radiation
HZS91_02237	COG0784	Response regulator, receiver
HZS91_02237	COG2205	protein histidine kinase activity
HZS91_02253	COG0800	Aldolase
HZS91_02254	COG0129	dihydroxy-acid dehydratase activity
HZS91_02255	COG0363	glucosamine-6-phosphate deaminase activity
HZS91_02256	COG0837	glucose binding
HZS91_02257	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HZS91_02262	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HZS91_02265	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HZS91_02266	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HZS91_02268	COG4591	ABC-type transport system involved in lipoprotein release permease component
HZS91_02269	COG1136	(ABC) transporter
HZS91_02272	COG0811	peptide transport
HZS91_02274	COG1132	(ABC) transporter
HZS91_02275	COG1663	tetraacyldisaccharide 4'-kinase activity
HZS91_02276	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HZS91_02277	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZS91_02279	COG0322	excinuclease ABC activity
HZS91_02280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZS91_02285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZS91_02286	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZS91_02294	COG0582	viral genome integration into host DNA
HZS91_02296	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HZS91_02300	COG1054	Belongs to the UPF0176 family
HZS91_02302	COG1530	ribonuclease E activity
HZS91_02304	COG3064	Membrane
HZS91_02305	COG0428	transporter
HZS91_02307	COG2154	pterin-4-alpha-carbinolamine dehydratase
HZS91_02308	COG0316	Belongs to the HesB IscA family
HZS91_02308	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HZS91_02317	COG2226	methyltransferase
HZS91_02317	COG1073	alpha beta
HZS91_02319	COG1028	Short-chain dehydrogenase reductase Sdr
HZS91_02338	COG1238	metal cluster binding
HZS91_02345	COG3279	Response regulator of the LytR AlgR family
HZS91_02354	COG4566	intracellular signal transduction
HZS91_02356	COG5001	Diguanylate cyclase
HZS91_02360	COG3685	Protein conserved in bacteria
HZS91_02365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HZS91_02365	COG1648	precorrin-2 dehydrogenase activity
HZS91_02368	COG2814	Major facilitator Superfamily
HZS91_02371	COG1335	isochorismatase
HZS91_02374	COG2197	response regulator
HZS91_02378	COG0583	DNA-binding transcription factor activity
HZS91_02379	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HZS91_02380	COG3002	Belongs to the UPF0753 family
HZS91_02382	COG1396	sequence-specific DNA binding
HZS91_02383	COG5489	Protein of unknown function (DUF736)
HZS91_02385	COG2003	Belongs to the UPF0758 family
HZS91_02391	COG0582	viral genome integration into host DNA
HZS91_02393	COG4774	siderophore transport
HZS91_02397	COG2336	PFAM SpoVT AbrB
HZS91_02402	COG4206	TonB-dependent receptor
HZS91_02410	COG2274	protein secretion by the type I secretion system
HZS91_02421	COG0270	DNA (cytosine-5-)-methyltransferase activity
HZS91_02431	COG4804	nuclease activity
HZS91_02432	COG2963	transposase activity
HZS91_02434	COG5006	permease, DMT superfamily
HZS91_02437	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZS91_02439	COG3938	Belongs to the proline racemase family
HZS91_02442	COG2807	transmembrane transport
HZS91_02443	COG2207	Transcriptional regulator
HZS91_02472	COG0210	DNA helicase
HZS91_02488	COG2084	Dehydrogenase
HZS91_02492	COG2003	Belongs to the UPF0758 family
HZS91_02499	COG0582	viral genome integration into host DNA
HZS91_02501	COG0519	Catalyzes the synthesis of GMP from XMP
HZS91_02501	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HZS91_02503	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HZS91_02505	COG0475	glutathione-regulated potassium exporter activity
HZS91_02505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZS91_02507	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HZS91_02509	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZS91_02510	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HZS91_02512	COG0776	regulation of translation
HZS91_02513	COG0539	negative regulation of cytoplasmic translation
HZS91_02514	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HZS91_02518	COG2957	Belongs to the agmatine deiminase family
HZS91_02519	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZS91_02524	COG0395	ABC-type sugar transport system, permease component
HZS91_02525	COG1175	transmembrane transport
HZS91_02531	COG2350	Protein conserved in bacteria
HZS91_02532	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HZS91_02533	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HZS91_02534	COG1187	pseudouridine synthase activity
HZS91_02538	COG0436	Aminotransferase
HZS91_02539	COG4133	protoheme IX ABC transporter activity
HZS91_02543	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HZS91_02544	COG1138	Cytochrome C-type biogenesis protein
HZS91_02548	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZS91_02549	COG1278	Cold shock
HZS91_02550	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HZS91_02551	COG4988	ABC transporter
HZS91_02553	COG1294	oxidase, subunit
HZS91_02559	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HZS91_02560	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HZS91_02562	COG0165	Argininosuccinate lyase
HZS91_02563	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HZS91_02565	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HZS91_02566	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZS91_02568	COG0137	argininosuccinate synthase activity
HZS91_02569	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZS91_02571	COG0215	cysteine-tRNA ligase activity
HZS91_02572	COG2166	iron-sulfur cluster assembly
HZS91_02575	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HZS91_02576	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZS91_02582	COG4302	ethanolamine ammonia-lyase activity
HZS91_02595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZS91_02596	COG0402	S-adenosylhomocysteine deaminase activity
HZS91_02598	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HZS91_02599	COG1509	lysine 2,3-aminomutase activity
HZS91_02600	COG3300	MHYT domain
HZS91_02600	COG5001	Diguanylate cyclase
HZS91_02603	COG0483	inositol monophosphate 1-phosphatase activity
HZS91_02604	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HZS91_02608	COG0488	(ABC) transporter
HZS91_02609	COG0513	Belongs to the DEAD box helicase family
HZS91_02610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZS91_02611	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HZS91_02613	COG0625	glutathione transferase activity
HZS91_02615	COG4681	YaeQ
HZS91_02616	COG2081	HI0933 family
HZS91_02618	COG0501	Belongs to the peptidase M48B family
HZS91_02619	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZS91_02620	COG1028	Short-chain dehydrogenase reductase Sdr
HZS91_02625	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HZS91_02626	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZS91_02627	COG0802	atpase or kinase
HZS91_02628	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HZS91_02628	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HZS91_02629	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HZS91_02630	COG1570	exodeoxyribonuclease VII activity
HZS91_02632	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HZS91_02672	COG0835	chemotaxis
HZS91_02673	COG0840	transmembrane signaling receptor activity
HZS91_02674	COG2094	Belongs to the DNA glycosylase MPG family
HZS91_02675	COG1201	RNA secondary structure unwinding
HZS91_02679	COG2969	positive regulation of protein catabolic process
HZS91_02680	COG0625	glutathione transferase activity
HZS91_02681	COG2857	Cytochrome c1
HZS91_02682	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HZS91_02683	COG0723	plastoquinol--plastocyanin reductase activity
HZS91_02685	COG0741	lytic transglycosylase activity
HZS91_02688	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZS91_02690	COG1702	phosphate starvation-inducible protein PhoH
HZS91_02692	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HZS91_02694	COG4535	Mg2 and Co2 transporter CorC
HZS91_02697	COG1012	belongs to the aldehyde dehydrogenase family
HZS91_02698	COG1177	transmembrane transport
HZS91_02699	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZS91_02700	COG3842	ATPase activity
HZS91_02704	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HZS91_02707	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HZS91_02708	COG0174	glutamine synthetase
HZS91_02709	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZS91_02711	COG2703	oxygen carrier activity
HZS91_02712	COG0477	Major facilitator Superfamily
HZS91_02714	COG0243	molybdopterin cofactor binding
HZS91_02715	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HZS91_02716	COG2223	nitrite transmembrane transporter activity
HZS91_02719	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZS91_02721	COG2733	membrane
HZS91_02722	COG5002	protein histidine kinase activity
HZS91_02722	COG2205	protein histidine kinase activity
HZS91_02722	COG0784	Response regulator, receiver
HZS91_02724	COG0477	Major facilitator Superfamily
HZS91_02726	COG2902	Dehydrogenase
HZS91_02728	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS91_02729	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZS91_02730	COG1609	Transcriptional regulator
HZS91_02731	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZS91_02731	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZS91_02732	COG1105	Belongs to the carbohydrate kinase PfkB family
HZS91_02733	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZS91_02733	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZS91_02743	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZS91_02745	COG1862	Preprotein translocase
HZS91_02746	COG0343	queuine tRNA-ribosyltransferase activity
HZS91_02747	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HZS91_02755	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HZS91_02756	COG3291	Pkd domain containing protein
HZS91_02757	COG0405	Gamma-glutamyltransferase
HZS91_02758	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZS91_02761	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HZS91_02762	COG0742	ribosomal rna small subunit methyltransferase
HZS91_02763	COG0326	Molecular chaperone. Has ATPase activity
HZS91_02781	COG0531	amino acid
HZS91_02784	COG0006	proline dipeptidase activity
HZS91_02786	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZS91_02789	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZS91_02790	COG3938	Belongs to the proline racemase family
HZS91_02792	COG0552	protein localization to endoplasmic reticulum
HZS91_02794	COG1194	a g-specific adenine glycosylase
HZS91_02795	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HZS91_02796	COG4191	Histidine kinase
HZS91_02796	COG0784	Response regulator, receiver
HZS91_02799	COG0322	excinuclease ABC activity
HZS91_02802	COG3040	lipid binding
HZS91_02805	COG1960	acyl-CoA dehydrogenase activity
HZS91_02807	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZS91_02811	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZS91_02812	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZS91_02813	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZS91_02818	COG0438	transferase activity, transferring glycosyl groups
HZS91_02820	COG0438	transferase activity, transferring glycosyl groups
HZS91_02821	COG0438	transferase activity, transferring glycosyl groups
HZS91_02831	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZS91_02831	COG0072	phenylalanine-tRNA ligase activity
HZS91_02832	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HZS91_02835	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HZS91_02836	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZS91_02841	COG1082	Xylose isomerase domain protein TIM barrel
HZS91_02844	COG0366	Alpha amylase catalytic
HZS91_02845	COG2801	Transposase and inactivated derivatives
HZS91_02856	COG3702	type iv secretory pathway
HZS91_02860	COG2948	multi-organism process
HZS91_02864	COG3505	Type IV secretory pathway VirD4
HZS91_02867	COG0556	nucleotide-excision repair
HZS91_02877	COG2963	transposase activity
HZS91_02885	COG4695	Portal protein
HZS91_02894	COG3179	chitinase
HZS91_02906	COG2963	transposase activity
HZS91_02913	COG3275	phosphorelay sensor kinase activity
HZS91_02914	COG1611	Belongs to the LOG family
HZS91_02917	COG2095	MarC family integral membrane protein
HZS91_02919	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HZS91_02926	COG1185	polyribonucleotide nucleotidyltransferase activity
HZS91_02927	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HZS91_02928	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HZS91_02929	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HZS91_02930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HZS91_02931	COG0195	Participates in both transcription termination and antitermination
HZS91_02932	COG0779	Required for maturation of 30S ribosomal subunits
HZS91_02934	COG1007	ATP synthesis coupled electron transport
HZS91_02939	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZS91_02940	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HZS91_02942	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HZS91_02943	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HZS91_02944	COG0649	NAD binding
HZS91_02945	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZS91_02946	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZS91_02947	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZS91_02950	COG0149	triose-phosphate isomerase activity
HZS91_02951	COG0300	oxidoreductase activity
HZS91_02957	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZS91_02958	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HZS91_02959	COG0159	tryptophan synthase activity
HZS91_02961	COG0133	tryptophan synthase activity
HZS91_02963	COG0135	phosphoribosylanthranilate isomerase activity
HZS91_02964	COG0101	tRNA pseudouridine synthase activity
HZS91_02968	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HZS91_02969	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZS91_02970	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HZS91_02971	COG2890	protein-(glutamine-N5) methyltransferase activity
HZS91_02973	COG0688	phosphatidylethanolamine metabolic process
HZS91_02976	COG0433	COG0433 Predicted ATPase
HZS91_02977	COG0494	nUDIX hydrolase
HZS91_02981	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZS91_02982	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZS91_02987	COG0717	Belongs to the dCTP deaminase family
HZS91_02989	COG0489	protein tyrosine kinase activity
HZS91_02993	COG3590	peptidase
HZS91_02995	COG3590	peptidase
HZS91_02999	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZS91_03000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZS91_03001	COG2311	Membrane
HZS91_03002	COG1047	Peptidyl-prolyl cis-trans
HZS91_03003	COG0791	NLP P60 protein
HZS91_03004	COG0791	NLP P60 protein
HZS91_03006	COG4106	trans-aconitate 2-methyltransferase activity
HZS91_03007	COG1301	dicarboxylic acid transport
HZS91_03008	COG1785	Belongs to the alkaline phosphatase family
HZS91_03010	COG0037	tRNA processing
HZS91_03011	COG1722	exodeoxyribonuclease VII activity
HZS91_03012	COG0142	geranyltranstransferase activity
HZS91_03013	COG4104	PAAR repeat-containing protein
HZS91_03015	COG0312	modulator of DNA gyrase
HZS91_03016	COG3028	Belongs to the UPF0307 family
HZS91_03017	COG0312	modulator of DNA gyrase
HZS91_03019	COG3164	Protein of unknown function
HZS91_03021	COG0424	maF-like protein
HZS91_03022	COG2968	Membrane
HZS91_03025	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HZS91_03028	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HZS91_03031	COG0495	leucyl-tRNA aminoacylation
HZS91_03033	COG3118	belongs to the thioredoxin family
HZS91_03038	COG2155	Conserved Protein
HZS91_03047	COG1132	(ABC) transporter
HZS91_03053	COG1538	Outer membrane efflux protein
HZS91_03054	COG0745	RESPONSE REGULATOR receiver
HZS91_03055	COG5000	phosphorelay sensor kinase activity
HZS91_03055	COG5002	protein histidine kinase activity
HZS91_03056	COG0475	glutathione-regulated potassium exporter activity
HZS91_03058	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HZS91_03063	COG1187	pseudouridine synthase activity
HZS91_03064	COG5002	protein histidine kinase activity
HZS91_03064	COG5001	Diguanylate cyclase
HZS91_03088	COG0667	Aldo Keto reductase
HZS91_03090	COG2814	Major facilitator Superfamily
HZS91_03091	COG0583	DNA-binding transcription factor activity
HZS91_03093	COG2207	Transcriptional regulator
HZS91_03095	COG1309	transcriptional regulator
HZS91_03100	COG0735	belongs to the Fur family
HZS91_03101	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZS91_03106	COG4452	Inner membrane protein CreD
HZS91_03109	COG2205	protein histidine kinase activity
HZS91_03110	COG0745	RESPONSE REGULATOR receiver
HZS91_03111	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HZS91_03114	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HZS91_03122	COG0643	Histidine kinase
HZS91_03122	COG2198	Histidine kinase
HZS91_03124	COG0840	transmembrane signaling receptor activity
HZS91_03125	COG0835	chemotaxis
HZS91_03126	COG2199	diguanylate cyclase activity
HZS91_03126	COG2200	EAL domain
HZS91_03126	COG2202	Pas domain
HZS91_03127	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HZS91_03128	COG2201	protein-glutamate methylesterase activity
HZS91_03129	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZS91_03130	COG3590	peptidase
HZS91_03132	COG0588	phosphoglycerate mutase activity
HZS91_03133	COG1515	deoxyribonuclease V activity
HZS91_03135	COG1741	Belongs to the pirin family
HZS91_03138	COG1741	Belongs to the pirin family
HZS91_03139	COG1966	Carbon starvation protein
HZS91_03140	COG2879	small protein
HZS91_03150	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZS91_03151	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HZS91_03152	COG2080	2 iron, 2 sulfur cluster binding
HZS91_03155	COG5001	Diguanylate cyclase
HZS91_03155	COG4251	negative regulation of phosphorylation
HZS91_03155	COG3706	GGDEF domain
HZS91_03155	COG2203	Gaf domain
HZS91_03156	COG0629	single-stranded DNA binding
HZS91_03157	COG0142	geranyltranstransferase activity
HZS91_03160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HZS91_03163	COG0527	aspartate kinase activity
HZS91_03164	COG0384	phenazine biosynthesis protein PhzF
HZS91_03165	COG0384	phenazine biosynthesis protein PhzF
HZS91_03167	COG1764	response to oxidative stress
HZS91_03168	COG0540	Belongs to the ATCase OTCase family
HZS91_03169	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HZS91_03170	COG1678	Uncharacterized ACR, COG1678
HZS91_03172	COG0519	Catalyzes the synthesis of GMP from XMP
HZS91_03174	COG5297	Belongs to the glycosyl hydrolase family 6
HZS91_03177	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HZS91_03180	COG0739	heme binding
HZS91_03184	COG0693	protein deglycase activity
HZS91_03186	COG1959	2 iron, 2 sulfur cluster binding
HZS91_03187	COG0719	Fe-S assembly protein
HZS91_03188	COG0396	ATPase activity
HZS91_03189	COG0719	Fe-S assembly protein
HZS91_03190	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZS91_03192	COG2146	nitrite reductase [NAD(P)H] activity
HZS91_03193	COG4774	siderophore transport
HZS91_03194	COG3128	pkhd-type hydroxylase
HZS91_03199	COG1477	protein flavinylation
HZS91_03200	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HZS91_03203	COG1555	photosystem II stabilization
HZS91_03204	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZS91_03206	COG3178	'Phosphotransferase
HZS91_03207	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HZS91_03209	COG0628	permease
HZS91_03211	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HZS91_03213	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HZS91_03217	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HZS91_03218	COG0271	Belongs to the BolA IbaG family
HZS91_03220	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HZS91_03222	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HZS91_03223	COG1137	ATPase activity
HZS91_03226	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZS91_03227	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HZS91_03228	COG1660	Displays ATPase and GTPase activities
HZS91_03230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZS91_03231	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZS91_03233	COG2239	Acts as a magnesium transporter
HZS91_03236	COG1294	oxidase, subunit
HZS91_03237	COG1271	oxidase subunit
HZS91_03239	COG1113	amino acid transport
HZS91_03245	COG2197	response regulator
HZS91_03246	COG0531	amino acid
HZS91_03253	COG1234	tRNA 3'-trailer cleavage
HZS91_03262	COG2814	Major facilitator Superfamily
HZS91_03264	COG0754	glutathionylspermidine amidase activity
HZS91_03269	COG1842	Phage shock protein A
HZS91_03271	COG0259	pyridoxamine-phosphate oxidase activity
HZS91_03272	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HZS91_03273	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HZS91_03275	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HZS91_03290	COG2814	Major facilitator Superfamily
HZS91_03293	COG2205	protein histidine kinase activity
HZS91_03293	COG2198	Histidine kinase
HZS91_03293	COG0784	Response regulator, receiver
HZS91_03294	COG2205	protein histidine kinase activity
HZS91_03294	COG2198	Histidine kinase
HZS91_03294	COG0784	Response regulator, receiver
HZS91_03295	COG2353	YceI-like domain
HZS91_03299	COG1760	l-serine dehydratase
HZS91_03302	COG0460	homoserine dehydrogenase
HZS91_03302	COG0527	aspartate kinase activity
HZS91_03303	COG0626	cystathionine gamma-synthase activity
HZS91_03304	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZS91_03305	COG0739	heme binding
HZS91_03306	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HZS91_03307	COG1272	protein, Hemolysin III
HZS91_03308	COG2982	Protein involved in outer membrane biogenesis
HZS91_03309	COG0516	GMP reductase activity
HZS91_03309	COG0517	IMP dehydrogenase activity
HZS91_03310	COG0463	Glycosyl transferase, family 2
HZS91_03311	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZS91_03312	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HZS91_03314	COG4771	TonB-dependent receptor
HZS91_03316	COG1309	transcriptional regulator
HZS91_03318	COG1960	acyl-CoA dehydrogenase activity
HZS91_03324	COG0509	glycine decarboxylation via glycine cleavage system
HZS91_03325	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HZS91_03327	COG0330	HflC and HflK could
HZS91_03328	COG1742	UPF0060 membrane protein
HZS91_03329	COG3956	TIGRFAM MazG family protein
HZS91_03331	COG0494	nUDIX hydrolase
HZS91_03333	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HZS91_03334	COG0837	glucose binding
HZS91_03337	COG1388	LysM domain
HZS91_03337	COG3858	chitin binding
HZS91_03338	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HZS91_03340	COG1472	Belongs to the glycosyl hydrolase 3 family
HZS91_03343	COG0531	amino acid
HZS91_03345	COG1486	melibiose metabolic process
HZS91_03347	COG3537	Alpha-1,2-mannosidase
HZS91_03355	COG3142	Participates in the control of copper homeostasis
HZS91_03356	COG1446	asparaginase
HZS91_03362	COG2198	Histidine kinase
HZS91_03362	COG0643	Histidine kinase
HZS91_03362	COG0784	Response regulator, receiver
HZS91_03363	COG0840	transmembrane signaling receptor activity
HZS91_03364	COG0835	chemotaxis
HZS91_03367	COG0189	ligase activity
HZS91_03369	COG1397	ADP-ribosylglycohydrolase
HZS91_03371	COG1199	ATP-dependent helicase activity
HZS91_03373	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZS91_03374	COG1215	transferase activity, transferring glycosyl groups
HZS91_03379	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZS91_03381	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HZS91_03382	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HZS91_03383	COG0535	radical SAM domain protein
HZS91_03384	COG0535	radical SAM domain protein
HZS91_03388	COG0837	glucose binding
HZS91_03391	COG1643	Atp-dependent helicase
HZS91_03392	COG0783	Belongs to the Dps family
HZS91_03394	COG0514	ATP-dependent DNA helicase (RecQ)
HZS91_03401	COG0840	transmembrane signaling receptor activity
HZS91_03405	COG3920	Histidine kinase
HZS91_03406	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HZS91_03408	COG0602	queuosine metabolic process
HZS91_03410	COG2885	chlorophyll binding
HZS91_03411	COG0823	Involved in the tonB-independent uptake of proteins
HZS91_03413	COG0848	biopolymer transport protein
HZS91_03415	COG0824	Thioesterase
HZS91_03416	COG2255	four-way junction helicase activity
HZS91_03418	COG3158	transport of potassium into the cell
HZS91_03419	COG0632	four-way junction helicase activity
HZS91_03420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HZS91_03421	COG0217	transcriptional regulatory protein
HZS91_03424	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HZS91_03427	COG0477	Major facilitator Superfamily
HZS91_03436	COG0488	(ABC) transporter
HZS91_03444	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZS91_03444	COG4651	solute:proton antiporter activity
HZS91_03449	COG4772	TonB-dependent receptor
HZS91_03451	COG4264	IucA IucC family
HZS91_03454	COG0019	diaminopimelate decarboxylase activity
HZS91_03459	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HZS91_03461	COG1492	cobalamin metabolic process
HZS91_03463	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HZS91_03467	COG4206	TonB-dependent receptor
HZS91_03468	COG0542	response to heat
HZS91_03469	COG1116	anion transmembrane transporter activity
HZS91_03470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZS91_03471	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZS91_03472	COG0667	Aldo Keto reductase
HZS91_03473	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZS91_03474	COG4771	TonB-dependent receptor
HZS91_03475	COG2827	Endonuclease containing a URI domain
HZS91_03484	COG1877	trehalose-phosphatase activity
HZS91_03485	COG3387	PFAM Glycoside hydrolase 15-related
HZS91_03489	COG0840	transmembrane signaling receptor activity
HZS91_03490	COG3011	Protein conserved in bacteria
HZS91_03493	COG0564	pseudouridine synthase activity
HZS91_03494	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZS91_03496	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HZS91_03496	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZS91_03501	COG2951	lytic endotransglycosylase activity
HZS91_03502	COG4644	lycopene metabolic process
HZS91_03505	COG2369	cell adhesion
HZS91_03510	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HZS91_03511	COG0045	succinate-CoA ligase (ADP-forming) activity
HZS91_03515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZS91_03522	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HZS91_03523	COG0237	dephospho-CoA kinase activity
HZS91_03529	COG5002	protein histidine kinase activity
HZS91_03530	COG0745	RESPONSE REGULATOR receiver
HZS91_03532	COG0189	ligase activity
HZS91_03548	COG2003	Belongs to the UPF0758 family
HZS91_03553	COG4191	Histidine kinase
HZS91_03553	COG0784	Response regulator, receiver
HZS91_03554	COG0784	Response regulator, receiver
HZS91_03554	COG4191	Histidine kinase
HZS91_03583	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HZS91_03590	COG2022	thiamine diphosphate biosynthetic process
HZS91_03591	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HZS91_03592	COG0471	metal ion transport
HZS91_03592	COG3273	potassium ion transport
HZS91_03597	COG1970	mechanosensitive ion channel activity
HZS91_03601	COG3250	beta-galactosidase activity
HZS91_03602	COG4948	Mandelate Racemase Muconate Lactonizing
HZS91_03605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZS91_03607	COG0308	aminopeptidase N
HZS91_03615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZS91_03617	COG0529	Catalyzes the synthesis of activated sulfate
HZS91_03617	COG2895	sulfate adenylyltransferase (ATP) activity
HZS91_03618	COG0175	sulfate reduction
HZS91_03619	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HZS91_03620	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZS91_03621	COG0175	sulfate reduction
HZS91_03625	COG2198	Histidine kinase
HZS91_03625	COG0784	Response regulator, receiver
HZS91_03625	COG2205	protein histidine kinase activity
HZS91_03629	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HZS91_03629	COG1648	precorrin-2 dehydrogenase activity
HZS91_03632	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HZS91_03633	COG3588	fructose-bisphosphate aldolase
HZS91_03636	COG0469	pyruvate kinase activity
HZS91_03638	COG0126	phosphoglycerate kinase activity
HZS91_03643	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HZS91_03645	COG3047	cAMP biosynthetic process
HZS91_03646	COG3047	cAMP biosynthetic process
HZS91_03648	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZS91_03648	COG3453	Protein conserved in bacteria
HZS91_03649	COG0725	ABC transporter, periplasmic molybdate-binding protein
HZS91_03650	COG4149	molybdate abc transporter
HZS91_03651	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HZS91_03658	COG1376	ErfK ybiS ycfS ynhG family protein
HZS91_03659	COG0739	heme binding
HZS91_03661	COG4773	Receptor
HZS91_03662	COG0596	Alpha beta hydrolase
HZS91_03663	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HZS91_03664	COG1301	dicarboxylic acid transport
HZS91_03666	COG2304	oxidoreductase activity
HZS91_03670	COG0714	Associated with various cellular activities
HZS91_03677	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HZS91_03682	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HZS91_03684	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZS91_03686	COG0194	GDP metabolic process
HZS91_03687	COG1561	YicC-like family, N-terminal region
HZS91_03688	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HZS91_03690	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HZS91_03691	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZS91_03694	COG0006	proline dipeptidase activity
HZS91_03696	COG0006	proline dipeptidase activity
HZS91_03697	COG3079	Belongs to the UPF0149 family
HZS91_03701	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HZS91_03703	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HZS91_03705	COG2912	Transglutaminase-like superfamily
HZS91_03706	COG1773	rubredoxin
HZS91_03707	COG0352	thiamine-phosphate diphosphorylase activity
HZS91_03710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZS91_03713	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZS91_03719	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZS91_03720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZS91_03722	COG1028	Short-chain dehydrogenase reductase Sdr
HZS91_03724	COG0671	phosphoesterase, PA-phosphatase related
HZS91_03725	COG3781	membrane
HZS91_03727	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZS91_03728	COG0563	adenylate kinase activity
HZS91_03731	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HZS91_03733	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HZS91_03737	COG3710	Transcriptional regulator
HZS91_03738	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HZS91_03741	COG0840	transmembrane signaling receptor activity
HZS91_03742	COG0405	Gamma-glutamyltransferase
HZS91_03743	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HZS91_03747	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZS91_03748	COG0473	3-isopropylmalate dehydrogenase activity
HZS91_03749	COG0066	3-isopropylmalate dehydratase activity
HZS91_03750	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HZS91_03754	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HZS91_03755	COG1538	Outer membrane efflux protein
HZS91_03756	COG1519	Transferase
HZS91_03757	COG1560	Kdo2-lipid A biosynthetic process
HZS91_03762	COG0280	phosphate acetyltransferase
HZS91_03762	COG0281	malic enzyme
HZS91_03763	COG1301	dicarboxylic acid transport
HZS91_03768	COG0583	DNA-binding transcription factor activity
HZS91_03769	COG0667	Aldo Keto reductase
HZS91_03772	COG2197	response regulator
HZS91_03774	COG0642	Histidine kinase
HZS91_03778	COG2851	Citrate transporter
HZS91_03779	COG1028	Short-chain dehydrogenase reductase Sdr
HZS91_03780	COG1609	Transcriptional regulator
HZS91_03782	COG2211	Major facilitator Superfamily
HZS91_03787	COG1162	GTPase activity
HZS91_03793	COG4773	Receptor
HZS91_03794	COG0726	polysaccharide deacetylase
HZS91_03795	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HZS91_03798	COG2801	Transposase and inactivated derivatives
HZS91_03802	COG1307	EDD domain protein, DegV family
HZS91_03803	COG0242	peptide deformylase activity
HZS91_03809	COG0457	Tetratricopeptide repeat
HZS91_03810	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HZS91_03811	COG1215	transferase activity, transferring glycosyl groups
HZS91_03812	COG1215	transferase activity, transferring glycosyl groups
HZS91_03815	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HZS91_03826	COG2188	Transcriptional regulator
HZS91_03829	COG1450	Type ii and iii secretion system protein
HZS91_03832	COG3166	PFAM Fimbrial assembly family protein
HZS91_03833	COG3156	type II secretion system protein K
HZS91_03834	COG4795	General secretion pathway protein
HZS91_03835	COG2165	general secretion pathway protein
HZS91_03836	COG4970	Tfp pilus assembly protein FimT
HZS91_03837	COG2165	general secretion pathway protein
HZS91_03838	COG1459	type II secretion system
HZS91_03840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZS91_03841	COG1404	Belongs to the peptidase S8 family
HZS91_03842	COG5295	Hep Hag repeat protein
HZS91_03843	COG1404	Belongs to the peptidase S8 family
HZS91_03844	COG5295	Hep Hag repeat protein
HZS91_03846	COG0047	phosphoribosylformylglycinamidine synthase activity
HZS91_03846	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZS91_03848	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HZS91_03850	COG4974	Belongs to the 'phage' integrase family
HZS91_03853	COG0795	lipopolysaccharide-transporting ATPase activity
HZS91_03855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HZS91_03858	COG0525	valine-tRNA ligase activity
HZS91_03864	COG1183	phosphatidylcholine synthase activity
HZS91_03866	COG0442	prolyl-tRNA aminoacylation
HZS91_03869	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HZS91_03870	COG1127	ABC transporter
HZS91_03871	COG3218	ABC-type transport auxiliary lipoprotein component
HZS91_03871	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HZS91_03878	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZS91_03879	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HZS91_03879	COG0662	Cupin 2, conserved barrel domain protein
HZS91_03886	COG2086	electron transfer activity
HZS91_03889	COG0546	phosphoglycolate phosphatase activity
HZS91_03889	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HZS91_03890	COG0277	FAD linked oxidase domain protein
HZS91_03893	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZS91_03899	COG0438	transferase activity, transferring glycosyl groups
HZS91_03899	COG1216	Glycosyl transferase, family 2
HZS91_03903	COG0626	cystathionine gamma-synthase activity
HZS91_03909	COG0625	glutathione transferase activity
HZS91_03912	COG0513	Belongs to the DEAD box helicase family
HZS91_03914	COG4206	TonB-dependent receptor
HZS91_03916	COG0720	synthase
HZS91_03918	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HZS91_03920	COG1956	GAF domain-containing protein
HZS91_03922	COG2819	hydrolase of the alpha beta superfamily
HZS91_03925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZS91_03926	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZS91_03929	COG0339	signal peptide processing
HZS91_03940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZS91_03941	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS91_03942	COG1136	(ABC) transporter
HZS91_03942	COG4591	ABC-type transport system involved in lipoprotein release permease component
HZS91_03943	COG0577	efflux transmembrane transporter activity
HZS91_03943	COG1136	(ABC) transporter
HZS91_03944	COG0577	efflux transmembrane transporter activity
HZS91_03948	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HZS91_03951	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HZS91_03952	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HZS91_03953	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HZS91_03954	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HZS91_03955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZS91_03956	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HZS91_03958	COG0356	it plays a direct role in the translocation of protons across the membrane
HZS91_03962	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZS91_03964	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZS91_03972	COG2011	ABC-type metal ion transport system permease component
HZS91_03973	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HZS91_03974	COG0697	spore germination
HZS91_03975	COG1666	GTP binding
HZS91_03977	COG2198	Histidine kinase
HZS91_03977	COG5002	protein histidine kinase activity
HZS91_03977	COG0784	Response regulator, receiver
HZS91_03982	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZS91_03983	COG1187	pseudouridine synthase activity
HZS91_03984	COG2813	Specifically methylates the guanine in position
HZS91_03988	COG2202	Pas domain
HZS91_03988	COG2205	protein histidine kinase activity
HZS91_03992	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HZS91_03993	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZS91_04005	COG0842	Transport permease protein
HZS91_04006	COG1131	(ABC) transporter
HZS91_04007	COG0025	NhaP-type Na H and K H
HZS91_04009	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HZS91_04010	COG1573	uracil-dna glycosylase
HZS91_04012	COG3384	dioxygenase
HZS91_04014	COG0583	DNA-binding transcription factor activity
HZS91_04016	COG0667	Aldo Keto reductase
HZS91_04019	COG3590	peptidase
HZS91_04023	COG0531	amino acid
HZS91_04026	COG2972	Histidine kinase
HZS91_04031	COG3685	Protein conserved in bacteria
HZS91_04032	COG3546	catalase activity
HZS91_04042	COG1271	oxidase subunit
HZS91_04043	COG1294	oxidase, subunit
HZS91_04046	COG1028	Short-chain dehydrogenase reductase Sdr
HZS91_04047	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HZS91_04051	COG1132	(ABC) transporter
HZS91_04054	COG1063	alcohol dehydrogenase
HZS91_04069	COG0251	oxidation-reduction process
HZS91_04075	COG0840	transmembrane signaling receptor activity
HZS91_04079	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HZS91_04088	COG0024	Methionine aminopeptidase
HZS91_04095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZS91_04096	COG1490	D-aminoacyl-tRNA deacylase activity
HZS91_04097	COG1560	Kdo2-lipid A biosynthetic process
HZS91_04108	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HZS91_04108	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZS91_04109	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HZS91_04110	COG0242	peptide deformylase activity
HZS91_04111	COG1652	LysM domain
HZS91_04112	COG0758	DNA mediated transformation
HZS91_04113	COG2922	Belongs to the Smg family
HZS91_04116	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZS91_04116	COG1754	DNA topoisomerase type I activity
HZS91_04117	COG0009	L-threonylcarbamoyladenylate synthase
HZS91_04120	COG1028	Short-chain dehydrogenase reductase Sdr
HZS91_04122	COG0616	signal peptide processing
HZS91_04123	COG0534	Mate efflux family protein
HZS91_04127	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HZS91_04128	COG0625	glutathione transferase activity
HZS91_04131	COG1252	NADH dehydrogenase
HZS91_04132	COG2860	membrane
HZS91_04133	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZS91_04134	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HZS91_04135	COG3437	response regulator, receiver
HZS91_04136	COG2177	Part of the ABC transporter FtsEX involved in
HZS91_04137	COG2884	Cell division ATP-binding protein ftsE
HZS91_04138	COG0513	Belongs to the DEAD box helicase family
HZS91_04139	COG3118	belongs to the thioredoxin family
HZS91_04140	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HZS91_04142	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HZS91_04143	COG0583	DNA-binding transcription factor activity
HZS91_04152	COG1518	maintenance of DNA repeat elements
HZS91_04153	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HZS91_04155	COG1652	LysM domain
HZS91_04156	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HZS91_04156	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HZS91_04157	COG1473	amidohydrolase
HZS91_04158	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS91_04159	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZS91_04161	COG5383	Protein conserved in bacteria
HZS91_04172	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HZS91_04173	COG3023	N-Acetylmuramoyl-L-alanine amidase
HZS91_04175	COG4948	Mandelate Racemase Muconate Lactonizing
HZS91_04177	COG0531	amino acid
HZS91_04180	COG4682	membrane
HZS91_04181	COG2133	pyrroloquinoline quinone binding
HZS91_04183	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HZS91_04184	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HZS91_04186	COG1610	YqeY-like protein
HZS91_04188	COG1295	ribonuclease BN
HZS91_04189	COG0358	DNA primase activity
HZS91_04192	COG0109	protoheme IX farnesyltransferase activity
HZS91_04198	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HZS91_04201	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HZS91_04210	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HZS91_04211	COG0739	heme binding
HZS91_04212	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HZS91_04214	COG2211	Major facilitator Superfamily
HZS91_04215	COG0708	Exodeoxyribonuclease III
HZS91_04216	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HZS91_04218	COG1192	Involved in chromosome partitioning
HZS91_04219	COG1475	DNA binding
HZS91_04223	COG0463	Glycosyl transferase, family 2
HZS91_04227	COG0756	dUTP diphosphatase activity
HZS91_04228	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZS91_04229	COG2003	Belongs to the UPF0758 family
HZS91_04230	COG0018	arginyl-trna synthetase
HZS91_04233	COG4221	oxidoreductase activity
HZS91_04234	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HZS91_04234	COG2755	lipolytic protein G-D-S-L family
HZS91_04236	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZS91_04237	COG1166	arginine decarboxylase activity
HZS91_04238	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HZS91_04247	COG0606	chelatase, subunit chli
HZS91_04250	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HZS91_04257	COG1690	Belongs to the RtcB family
HZS91_04264	COG1090	epimerase
HZS91_04266	COG0642	Histidine kinase
HZS91_04272	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZS91_04277	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZS91_04278	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HZS91_04281	COG0753	catalase activity
HZS91_04284	COG2197	response regulator
HZS91_04285	COG4585	Histidine kinase
HZS91_04286	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS91_04287	COG1136	(ABC) transporter
HZS91_04291	COG2962	Rard protein
HZS91_04292	COG0697	spore germination
HZS91_04296	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZS91_04297	COG0180	Tryptophanyl-tRNA synthetase
HZS91_04298	COG3237	CsbD-like
HZS91_04307	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HZS91_04310	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HZS91_04320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZS91_04326	COG1199	ATP-dependent helicase activity
HZS91_04329	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HZS91_04342	COG0625	glutathione transferase activity
HZS91_04350	COG4555	ABC transporter
HZS91_04352	COG1476	TRANSCRIPTIONal
HZS91_04361	COG0543	2 iron, 2 sulfur cluster binding
HZS91_04361	COG0633	Ferredoxin
HZS91_04362	COG1131	(ABC) transporter
HZS91_04363	COG0842	Transport permease protein
HZS91_04365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HZS91_04372	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZS91_04373	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZS91_04376	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZS91_04376	COG1042	CoA-binding domain protein
HZS91_04376	COG0045	succinate-CoA ligase (ADP-forming) activity
HZS91_04377	COG2239	Acts as a magnesium transporter
HZS91_04378	COG3338	carbonate dehydratase activity
HZS91_04380	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HZS91_04381	COG3387	PFAM Glycoside hydrolase 15-related
HZS91_04384	COG3100	YcgL domain-containing protein
HZS91_04385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZS91_04387	COG0463	Glycosyl transferase, family 2
HZS91_04391	COG1028	Short-chain dehydrogenase reductase Sdr
HZS91_04399	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZS91_04402	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZS91_04408	COG0823	Involved in the tonB-independent uptake of proteins
HZS91_04408	COG1506	peptidase
HZS91_04408	COG4946	Tricorn protease homolog
HZS91_04412	COG0408	coproporphyrinogen oxidase activity
HZS91_04420	COG0515	serine threonine protein kinase
HZS91_04420	COG2815	serine threonine protein kinase
HZS91_04421	COG0631	protein serine/threonine phosphatase activity
HZS91_04457	COG0210	DNA helicase
HZS91_04460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZS91_04461	COG0583	DNA-binding transcription factor activity
HZS91_04462	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HZS91_04465	COG2159	amidohydrolase
HZS91_04469	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZS91_04473	COG0357	Ribosomal RNA small subunit methyltransferase G
HZS91_04474	COG3540	Alkaline phosphatase
HZS91_04476	COG2091	lysine biosynthetic process via aminoadipic acid
HZS91_04479	COG0708	Exodeoxyribonuclease III
HZS91_04480	COG1846	Transcriptional regulator
HZS91_04480	COG1940	carbohydrate kinase activity
HZS91_04482	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZS91_04484	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZS91_04485	COG3162	membrane
HZS91_04487	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZS91_04493	COG3507	Belongs to the glycosyl hydrolase 43 family
HZS91_04497	COG1028	Short-chain dehydrogenase reductase Sdr
HZS91_04498	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZS91_04500	COG4948	Mandelate Racemase Muconate Lactonizing
HZS91_04501	COG3254	rhamnose metabolic process
HZS91_04502	COG0738	Major facilitator superfamily
HZS91_04503	COG1414	Transcriptional regulator
HZS91_04504	COG1971	Probably functions as a manganese efflux pump
HZS91_04505	COG2205	protein histidine kinase activity
HZS91_04508	COG3459	Glycosyltransferase 36 associated
HZS91_04509	COG2211	Major facilitator Superfamily
HZS91_04510	COG3265	gluconokinase activity
HZS91_04511	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZS91_04515	COG2911	Protein conserved in bacteria
HZS91_04516	COG0729	surface antigen
HZS91_04520	COG2963	transposase activity
HZS91_04524	COG0752	glycyl-tRNA synthetase alpha subunit
HZS91_04525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZS91_04528	COG0519	Catalyzes the synthesis of GMP from XMP
HZS91_04528	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HZS91_04530	COG0805	protein transport
HZS91_04531	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZS91_04532	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZS91_04534	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HZS91_04539	COG2974	May be involved in recombination
HZS91_04540	COG0037	tRNA processing
HZS91_04542	COG2115	Belongs to the xylose isomerase family
HZS91_04544	COG3661	Belongs to the glycosyl hydrolase 67 family
HZS91_04546	COG4948	Mandelate Racemase Muconate Lactonizing
HZS91_04548	COG1472	Belongs to the glycosyl hydrolase 3 family
HZS91_04549	COG0246	Mannitol dehydrogenase
HZS91_04559	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZS91_04565	COG3386	PFAM SMP-30 Gluconolaconase
HZS91_04567	COG3250	beta-galactosidase activity
HZS91_04568	COG1904	glucuronate isomerase
HZS91_04569	COG3693	PFAM glycoside hydrolase, family 10
HZS91_04571	COG3693	PFAM glycoside hydrolase, family 10
HZS91_04574	COG2211	Major facilitator Superfamily
HZS91_04588	COG2937	Belongs to the GPAT DAPAT family
HZS91_04595	COG0284	orotidine-5'-phosphate decarboxylase activity
HZS91_04596	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HZS91_04598	COG3132	Protein of unknown function, DUF480
HZS91_04601	COG0210	DNA helicase
HZS91_04602	COG1435	thymidine kinase activity
HZS91_04604	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HZS91_04606	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HZS91_04613	COG3135	benzoate transporter
HZS91_04617	COG0676	glucose-6-phosphate 1-epimerase activity
HZS91_04619	COG3012	SEC-C Motif Domain Protein
HZS91_04620	COG0730	response to heat
HZS91_04625	COG0302	gtp cyclohydrolase
HZS91_04628	COG1566	PFAM secretion protein HlyD family protein
HZS91_04630	COG1289	transmembrane transporter activity
HZS91_04631	COG0477	Major facilitator Superfamily
HZS91_04633	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZS91_04637	COG4691	Plasmid stability protein
HZS91_04638	COG1487	ribonuclease activity
HZS91_04645	COG0564	pseudouridine synthase activity
HZS91_04648	COG2963	transposase activity
HZS91_04653	COG0439	Biotin carboxylase
HZS91_04661	COG1074	ATP-dependent DNA helicase activity
HZS91_04662	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HZS91_04665	COG1127	ABC transporter
HZS91_04666	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HZS91_04667	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HZS91_04670	COG2853	Lipoprotein
HZS91_04672	COG0386	Belongs to the glutathione peroxidase family
HZS91_04674	COG1322	Protein conserved in bacteria
HZS91_04675	COG0604	alcohol dehydrogenase
HZS91_04679	COG0625	glutathione transferase activity
HZS91_04681	COG0531	amino acid
HZS91_04683	COG3537	Alpha-1,2-mannosidase
HZS91_04686	COG3706	GGDEF domain
HZS91_04687	COG3835	regulator
HZS91_04688	COG1929	Belongs to the glycerate kinase type-1 family
HZS91_04689	COG2271	Major facilitator Superfamily
HZS91_04692	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HZS91_04694	COG0861	Integral membrane protein TerC family
HZS91_04697	COG0584	glycerophosphoryl diester phosphodiesterase
HZS91_04700	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HZS91_04701	COG0726	polysaccharide deacetylase
HZS91_04702	COG0706	membrane insertase activity
HZS91_04703	COG0594	ribonuclease P activity
HZS91_04713	COG0534	Mate efflux family protein
HZS91_04719	COG2963	transposase activity
HZS91_04722	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HZS91_04722	COG2273	Hydrolase Family 16
HZS91_04729	COG2963	transposase activity
HZS91_04732	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZS91_05024	COG4644	lycopene metabolic process
HZS91_05025	COG2951	lytic endotransglycosylase activity
HZS91_05035	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZS91_05039	COG3012	SEC-C Motif Domain Protein
HZS91_05039	COG3318	Belongs to the UPF0149 family
HZS91_05046	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZS91_05048	COG4456	Virulence-associated protein
HZS91_05069	COG3504	Conjugal transfer protein
HZS91_05070	COG2948	multi-organism process