locus-tag	class	description
B7L65_00020	COG0367	asparagine synthase
B7L65_00040	COG0438	transferase activity, transferring glycosyl groups
B7L65_00040	COG0297	glycogen (starch) synthase activity
B7L65_00045	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B7L65_00110	COG0067	glutamate synthase
B7L65_00110	COG0069	glutamate synthase activity
B7L65_00110	COG0070	glutamate synthase
B7L65_00115	COG0493	'glutamate synthase
B7L65_00120	COG1064	alcohol dehydrogenase
B7L65_00130	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L65_00175	COG2937	Belongs to the GPAT DAPAT family
B7L65_00210	COG0284	orotidine-5'-phosphate decarboxylase activity
B7L65_00215	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
B7L65_00240	COG0210	DNA helicase
B7L65_00245	COG1435	thymidine kinase activity
B7L65_00270	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B7L65_00280	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B7L65_00310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B7L65_00315	COG0739	heme binding
B7L65_00320	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B7L65_00330	COG2223	nitrite transmembrane transporter activity
B7L65_00335	COG0708	Exodeoxyribonuclease III
B7L65_00340	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B7L65_00350	COG1192	Involved in chromosome partitioning
B7L65_00355	COG1475	DNA binding
B7L65_00375	COG0463	Glycosyl transferase, family 2
B7L65_00395	COG0756	dUTP diphosphatase activity
B7L65_00400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B7L65_00405	COG2003	Belongs to the UPF0758 family
B7L65_00410	COG0018	arginyl-trna synthetase
B7L65_00425	COG4221	oxidoreductase activity
B7L65_00430	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B7L65_00430	COG2755	lipolytic protein G-D-S-L family
B7L65_00440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B7L65_00445	COG1166	arginine decarboxylase activity
B7L65_00450	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B7L65_00490	COG0606	chelatase, subunit chli
B7L65_00510	COG4943	cyclic-guanylate-specific phosphodiesterase activity
B7L65_00550	COG1690	Belongs to the RtcB family
B7L65_00585	COG1090	epimerase
B7L65_00590	COG0745	RESPONSE REGULATOR receiver
B7L65_00595	COG0642	Histidine kinase
B7L65_00625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B7L65_00650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B7L65_00655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B7L65_00670	COG0753	catalase activity
B7L65_00685	COG2197	response regulator
B7L65_00690	COG4585	Histidine kinase
B7L65_00695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L65_00700	COG1136	(ABC) transporter
B7L65_00725	COG0697	spore germination
B7L65_00745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L65_00750	COG0180	Tryptophanyl-tRNA synthetase
B7L65_00755	COG3237	CsbD-like
B7L65_00800	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B7L65_00815	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B7L65_00850	COG2205	protein histidine kinase activity
B7L65_00855	COG0745	RESPONSE REGULATOR receiver
B7L65_00865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B7L65_00895	COG1199	ATP-dependent helicase activity
B7L65_00910	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B7L65_00975	COG0625	glutathione transferase activity
B7L65_01015	COG4555	ABC transporter
B7L65_01025	COG1476	TRANSCRIPTIONal
B7L65_01070	COG0633	Ferredoxin
B7L65_01070	COG0543	2 iron, 2 sulfur cluster binding
B7L65_01075	COG1131	(ABC) transporter
B7L65_01080	COG0842	Transport permease protein
B7L65_01090	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B7L65_01125	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B7L65_01135	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B7L65_01155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B7L65_01155	COG1042	CoA-binding domain protein
B7L65_01155	COG0045	succinate-CoA ligase (ADP-forming) activity
B7L65_01160	COG2239	Acts as a magnesium transporter
B7L65_01180	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B7L65_01185	COG3387	PFAM Glycoside hydrolase 15-related
B7L65_01200	COG3100	YcgL domain-containing protein
B7L65_01205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B7L65_01215	COG0463	Glycosyl transferase, family 2
B7L65_01235	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_01270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B7L65_01285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B7L65_01315	COG0823	Involved in the tonB-independent uptake of proteins
B7L65_01315	COG4946	Tricorn protease homolog
B7L65_01315	COG1506	peptidase
B7L65_01335	COG0408	coproporphyrinogen oxidase activity
B7L65_01375	COG0515	serine threonine protein kinase
B7L65_01375	COG2815	serine threonine protein kinase
B7L65_01380	COG0631	protein serine/threonine phosphatase activity
B7L65_01415	COG3501	Rhs element vgr protein
B7L65_01550	COG0210	DNA helicase
B7L65_01565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L65_01570	COG0583	DNA-binding transcription factor activity
B7L65_01575	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B7L65_01590	COG2159	amidohydrolase
B7L65_01595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B7L65_01600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B7L65_01610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L65_01630	COG0357	Ribosomal RNA small subunit methyltransferase G
B7L65_01635	COG3540	Alkaline phosphatase
B7L65_01645	COG2091	lysine biosynthetic process via aminoadipic acid
B7L65_01660	COG0708	Exodeoxyribonuclease III
B7L65_01665	COG1846	Transcriptional regulator
B7L65_01665	COG1940	carbohydrate kinase activity
B7L65_01675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B7L65_01685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B7L65_01690	COG3162	membrane
B7L65_01700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B7L65_01730	COG3507	Belongs to the glycosyl hydrolase 43 family
B7L65_01750	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_01755	COG0179	Fumarylacetoacetate (FAA) hydrolase
B7L65_01765	COG4948	Mandelate Racemase Muconate Lactonizing
B7L65_01775	COG3254	rhamnose metabolic process
B7L65_01780	COG0738	Major facilitator superfamily
B7L65_01785	COG1414	Transcriptional regulator
B7L65_01790	COG1971	Probably functions as a manganese efflux pump
B7L65_01795	COG2205	protein histidine kinase activity
B7L65_01810	COG3459	Glycosyltransferase 36 associated
B7L65_01815	COG2211	Major facilitator Superfamily
B7L65_01820	COG3265	gluconokinase activity
B7L65_01830	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B7L65_01850	COG2911	Protein conserved in bacteria
B7L65_01855	COG0729	surface antigen
B7L65_01885	COG0752	glycyl-tRNA synthetase alpha subunit
B7L65_01890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B7L65_01920	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B7L65_01920	COG0519	Catalyzes the synthesis of GMP from XMP
B7L65_01930	COG0805	protein transport
B7L65_01935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B7L65_01940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B7L65_01950	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B7L65_01975	COG2974	May be involved in recombination
B7L65_01990	COG2115	Belongs to the xylose isomerase family
B7L65_02000	COG3661	Belongs to the glycosyl hydrolase 67 family
B7L65_02010	COG4948	Mandelate Racemase Muconate Lactonizing
B7L65_02020	COG1472	Belongs to the glycosyl hydrolase 3 family
B7L65_02025	COG0246	Mannitol dehydrogenase
B7L65_02075	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B7L65_02105	COG3386	PFAM SMP-30 Gluconolaconase
B7L65_02115	COG3250	beta-galactosidase activity
B7L65_02120	COG1904	glucuronate isomerase
B7L65_02135	COG3693	PFAM glycoside hydrolase, family 10
B7L65_02150	COG2211	Major facilitator Superfamily
B7L65_02195	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L65_02205	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L65_02215	COG2234	aminopeptidase activity
B7L65_02225	COG4942	peptidase
B7L65_02230	COG0793	Belongs to the peptidase S41A family
B7L65_02290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L65_02300	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B7L65_02330	COG0501	Belongs to the peptidase M48B family
B7L65_02340	COG0187	DNA topoisomerase II activity
B7L65_02345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B7L65_02355	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B7L65_02365	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B7L65_02370	COG0594	ribonuclease P activity
B7L65_02375	COG0706	membrane insertase activity
B7L65_02380	COG0726	polysaccharide deacetylase
B7L65_02385	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B7L65_02400	COG0584	glycerophosphoryl diester phosphodiesterase
B7L65_02415	COG0861	Integral membrane protein TerC family
B7L65_02425	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B7L65_02440	COG2271	Major facilitator Superfamily
B7L65_02445	COG1929	Belongs to the glycerate kinase type-1 family
B7L65_02450	COG3835	regulator
B7L65_02455	COG3706	GGDEF domain
B7L65_02470	COG3537	Alpha-1,2-mannosidase
B7L65_02475	COG0531	amino acid
B7L65_02485	COG0625	glutathione transferase activity
B7L65_02500	COG0583	DNA-binding transcription factor activity
B7L65_02505	COG0604	alcohol dehydrogenase
B7L65_02510	COG1322	Protein conserved in bacteria
B7L65_02520	COG0386	Belongs to the glutathione peroxidase family
B7L65_02530	COG2853	Lipoprotein
B7L65_02545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B7L65_02550	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B7L65_02555	COG1127	ABC transporter
B7L65_02570	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B7L65_02575	COG1074	ATP-dependent DNA helicase activity
B7L65_02610	COG0439	Biotin carboxylase
B7L65_02650	COG0564	pseudouridine synthase activity
B7L65_02675	COG1487	ribonuclease activity
B7L65_02680	COG4691	Plasmid stability protein
B7L65_02700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L65_02710	COG0477	Major facilitator Superfamily
B7L65_02715	COG1289	transmembrane transporter activity
B7L65_02725	COG1566	PFAM secretion protein HlyD family protein
B7L65_02740	COG0302	gtp cyclohydrolase
B7L65_02760	COG0730	response to heat
B7L65_02765	COG3012	SEC-C Motif Domain Protein
B7L65_02775	COG0676	glucose-6-phosphate 1-epimerase activity
B7L65_02795	COG3135	benzoate transporter
B7L65_02855	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B7L65_02865	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
B7L65_02895	COG0109	protoheme IX farnesyltransferase activity
B7L65_02910	COG0358	DNA primase activity
B7L65_02915	COG1295	ribonuclease BN
B7L65_02925	COG1610	YqeY-like protein
B7L65_02930	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B7L65_02935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B7L65_02940	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B7L65_02950	COG2133	pyrroloquinoline quinone binding
B7L65_02955	COG4682	membrane
B7L65_02970	COG0531	amino acid
B7L65_02980	COG4948	Mandelate Racemase Muconate Lactonizing
B7L65_02990	COG3023	N-Acetylmuramoyl-L-alanine amidase
B7L65_02995	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
B7L65_03045	COG5383	Protein conserved in bacteria
B7L65_03055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L65_03060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L65_03065	COG1473	amidohydrolase
B7L65_03070	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B7L65_03070	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B7L65_03075	COG1652	LysM domain
B7L65_03100	COG1518	maintenance of DNA repeat elements
B7L65_03145	COG0583	DNA-binding transcription factor activity
B7L65_03150	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
B7L65_03160	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B7L65_03165	COG3118	belongs to the thioredoxin family
B7L65_03170	COG0513	Belongs to the DEAD box helicase family
B7L65_03175	COG2884	Cell division ATP-binding protein ftsE
B7L65_03180	COG2177	Part of the ABC transporter FtsEX involved in
B7L65_03185	COG2201	protein-glutamate methylesterase activity
B7L65_03190	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B7L65_03195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B7L65_03200	COG2860	membrane
B7L65_03205	COG1252	NADH dehydrogenase
B7L65_03220	COG0625	glutathione transferase activity
B7L65_03225	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B7L65_03245	COG0534	Mate efflux family protein
B7L65_03250	COG0616	signal peptide processing
B7L65_03260	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_03275	COG0009	L-threonylcarbamoyladenylate synthase
B7L65_03280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L65_03280	COG1754	DNA topoisomerase type I activity
B7L65_03300	COG0758	DNA mediated transformation
B7L65_03305	COG1652	LysM domain
B7L65_03310	COG0242	peptide deformylase activity
B7L65_03315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B7L65_03320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B7L65_03320	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B7L65_03375	COG1560	Kdo2-lipid A biosynthetic process
B7L65_03380	COG1490	D-aminoacyl-tRNA deacylase activity
B7L65_03385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B7L65_03480	COG0024	Methionine aminopeptidase
B7L65_03520	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B7L65_03540	COG0840	transmembrane signaling receptor activity
B7L65_03555	COG0251	oxidation-reduction process
B7L65_03630	COG1063	alcohol dehydrogenase
B7L65_03655	COG1132	(ABC) transporter
B7L65_03680	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_03695	COG1294	oxidase, subunit
B7L65_03700	COG1271	oxidase subunit
B7L65_03750	COG3546	catalase activity
B7L65_03755	COG3685	Protein conserved in bacteria
B7L65_03780	COG2972	Histidine kinase
B7L65_03795	COG0531	amino acid
B7L65_03815	COG3590	peptidase
B7L65_03830	COG0667	Aldo Keto reductase
B7L65_03840	COG0583	DNA-binding transcription factor activity
B7L65_03850	COG3384	dioxygenase
B7L65_03860	COG1573	uracil-dna glycosylase
B7L65_03865	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B7L65_03875	COG0025	NhaP-type Na H and K H
B7L65_03880	COG1131	(ABC) transporter
B7L65_03885	COG0842	Transport permease protein
B7L65_03945	COG1522	sequence-specific DNA binding
B7L65_03950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L65_03955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B7L65_03975	COG2202	Pas domain
B7L65_03975	COG2205	protein histidine kinase activity
B7L65_03995	COG2813	Specifically methylates the guanine in position
B7L65_04000	COG1187	pseudouridine synthase activity
B7L65_04005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B7L65_04025	COG0784	Response regulator, receiver
B7L65_04025	COG5002	protein histidine kinase activity
B7L65_04025	COG2198	Histidine kinase
B7L65_04035	COG1666	GTP binding
B7L65_04040	COG0697	spore germination
B7L65_04045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B7L65_04050	COG2011	ABC-type metal ion transport system permease component
B7L65_04090	COG0508	dehydrogenase complex catalyzes the overall conversion of
B7L65_04100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B7L65_04120	COG0356	it plays a direct role in the translocation of protons across the membrane
B7L65_04130	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B7L65_04135	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B7L65_04140	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B7L65_04145	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B7L65_04150	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B7L65_04155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B7L65_04170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B7L65_04175	COG4191	Histidine kinase
B7L65_04180	COG2204	response regulator
B7L65_04190	COG0577	efflux transmembrane transporter activity
B7L65_04195	COG0577	efflux transmembrane transporter activity
B7L65_04200	COG1136	(ABC) transporter
B7L65_04200	COG4591	ABC-type transport system involved in lipoprotein release permease component
B7L65_04205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L65_04210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B7L65_04265	COG0339	signal peptide processing
B7L65_04280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B7L65_04285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B7L65_04325	COG1956	GAF domain-containing protein
B7L65_04335	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B7L65_04345	COG0720	synthase
B7L65_04350	COG4206	TonB-dependent receptor
B7L65_04360	COG0513	Belongs to the DEAD box helicase family
B7L65_04375	COG0625	glutathione transferase activity
B7L65_04405	COG0626	cystathionine gamma-synthase activity
B7L65_04420	COG0110	maltose O-acetyltransferase activity
B7L65_04425	COG1216	Glycosyl transferase, family 2
B7L65_04425	COG0438	transferase activity, transferring glycosyl groups
B7L65_04430	COG3754	Rhamnan synthesis protein F
B7L65_04470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B7L65_04480	COG0300	oxidoreductase activity
B7L65_04485	COG0277	FAD linked oxidase domain protein
B7L65_04490	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B7L65_04490	COG0546	phosphoglycolate phosphatase activity
B7L65_04505	COG2086	electron transfer activity
B7L65_04540	COG0662	Cupin 2, conserved barrel domain protein
B7L65_04540	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
B7L65_04545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B7L65_04580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B7L65_04580	COG3218	ABC-type transport auxiliary lipoprotein component
B7L65_04585	COG1127	ABC transporter
B7L65_04590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B7L65_04605	COG0442	prolyl-tRNA aminoacylation
B7L65_04615	COG1183	phosphatidylcholine synthase activity
B7L65_04645	COG0525	valine-tRNA ligase activity
B7L65_04660	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B7L65_04670	COG0795	lipopolysaccharide-transporting ATPase activity
B7L65_04685	COG4974	Belongs to the 'phage' integrase family
B7L65_04700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B7L65_04715	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B7L65_04715	COG0047	phosphoribosylformylglycinamidine synthase activity
B7L65_04725	COG5295	Hep Hag repeat protein
B7L65_04730	COG1404	Belongs to the peptidase S8 family
B7L65_04735	COG5295	Hep Hag repeat protein
B7L65_04740	COG1404	Belongs to the peptidase S8 family
B7L65_04745	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B7L65_04755	COG1459	type II secretion system
B7L65_04760	COG2165	general secretion pathway protein
B7L65_04765	COG4970	Tfp pilus assembly protein FimT
B7L65_04770	COG2165	general secretion pathway protein
B7L65_04775	COG4795	General secretion pathway protein
B7L65_04780	COG3156	type II secretion system protein K
B7L65_04785	COG3166	PFAM Fimbrial assembly family protein
B7L65_04800	COG1450	Type ii and iii secretion system protein
B7L65_04810	COG2188	Transcriptional regulator
B7L65_04865	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B7L65_04880	COG1215	transferase activity, transferring glycosyl groups
B7L65_04885	COG1215	transferase activity, transferring glycosyl groups
B7L65_04890	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
B7L65_04925	COG0242	peptide deformylase activity
B7L65_04930	COG1307	EDD domain protein, DegV family
B7L65_04965	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B7L65_04970	COG0726	polysaccharide deacetylase
B7L65_04975	COG4773	Receptor
B7L65_05005	COG1162	GTPase activity
B7L65_05030	COG2211	Major facilitator Superfamily
B7L65_05035	COG1609	Transcriptional regulator
B7L65_05040	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_05045	COG2851	Citrate transporter
B7L65_05065	COG0642	Histidine kinase
B7L65_05070	COG1840	ABC-type Fe3 transport system, periplasmic component
B7L65_05075	COG2197	response regulator
B7L65_05090	COG0667	Aldo Keto reductase
B7L65_05100	COG0583	DNA-binding transcription factor activity
B7L65_05125	COG1301	dicarboxylic acid transport
B7L65_05130	COG0281	malic enzyme
B7L65_05130	COG0280	phosphate acetyltransferase
B7L65_05155	COG1560	Kdo2-lipid A biosynthetic process
B7L65_05165	COG1519	Transferase
B7L65_05170	COG1538	Outer membrane efflux protein
B7L65_05175	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B7L65_05195	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B7L65_05200	COG0066	3-isopropylmalate dehydratase activity
B7L65_05205	COG0473	3-isopropylmalate dehydrogenase activity
B7L65_05210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B7L65_05230	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B7L65_05235	COG0405	Gamma-glutamyltransferase
B7L65_05240	COG0840	transmembrane signaling receptor activity
B7L65_05255	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B7L65_05260	COG3710	Transcriptional regulator
B7L65_05280	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B7L65_05290	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B7L65_05305	COG0563	adenylate kinase activity
B7L65_05310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B7L65_05320	COG3781	membrane
B7L65_05325	COG0671	phosphoesterase, PA-phosphatase related
B7L65_05335	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_05340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B7L65_05345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B7L65_05375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B7L65_05390	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B7L65_05405	COG0352	thiamine-phosphate diphosphorylase activity
B7L65_05410	COG1773	rubredoxin
B7L65_05415	COG2912	Transglutaminase-like superfamily
B7L65_05425	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B7L65_05435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B7L65_05455	COG3079	Belongs to the UPF0149 family
B7L65_05460	COG0006	proline dipeptidase activity
B7L65_05470	COG0006	proline dipeptidase activity
B7L65_05485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B7L65_05490	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B7L65_05500	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B7L65_05505	COG1561	YicC-like family, N-terminal region
B7L65_05510	COG0194	GDP metabolic process
B7L65_05515	COG1758	RNA polymerase activity
B7L65_05520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B7L65_05530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B7L65_05540	COG0254	rRNA binding
B7L65_05555	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B7L65_05590	COG0714	Associated with various cellular activities
B7L65_05610	COG2304	oxidoreductase activity
B7L65_05625	COG1301	dicarboxylic acid transport
B7L65_05630	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B7L65_05635	COG0596	Alpha beta hydrolase
B7L65_05640	COG4773	Receptor
B7L65_05650	COG0739	heme binding
B7L65_05655	COG1376	ErfK ybiS ycfS ynhG family protein
B7L65_05690	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B7L65_05695	COG4149	molybdate abc transporter
B7L65_05700	COG0725	ABC transporter, periplasmic molybdate-binding protein
B7L65_05705	COG3453	Protein conserved in bacteria
B7L65_05705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L65_05715	COG3047	cAMP biosynthetic process
B7L65_05730	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B7L65_05755	COG0126	phosphoglycerate kinase activity
B7L65_05765	COG0469	pyruvate kinase activity
B7L65_05780	COG3588	fructose-bisphosphate aldolase
B7L65_05785	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B7L65_05800	COG1648	precorrin-2 dehydrogenase activity
B7L65_05800	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B7L65_05840	COG0175	sulfate reduction
B7L65_05845	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B7L65_05850	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B7L65_05855	COG0175	sulfate reduction
B7L65_05860	COG0529	Catalyzes the synthesis of activated sulfate
B7L65_05860	COG2895	sulfate adenylyltransferase (ATP) activity
B7L65_05885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L65_05950	COG2003	Belongs to the UPF0758 family
B7L65_06050	COG0745	RESPONSE REGULATOR receiver
B7L65_06055	COG5002	protein histidine kinase activity
B7L65_06085	COG0237	dephospho-CoA kinase activity
B7L65_06090	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B7L65_06140	COG0045	succinate-CoA ligase (ADP-forming) activity
B7L65_06145	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B7L65_06170	COG2369	cell adhesion
B7L65_06435	COG0784	Response regulator, receiver
B7L65_06435	COG4191	Histidine kinase
B7L65_06440	COG0745	RESPONSE REGULATOR receiver
B7L65_06505	COG4695	Portal protein
B7L65_06545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B7L65_06555	COG2201	protein-glutamate methylesterase activity
B7L65_06570	COG0544	peptidyl-prolyl cis-trans isomerase activity
B7L65_06575	COG0740	serine-type endopeptidase activity
B7L65_06580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B7L65_06610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B7L65_06620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L65_06630	COG0328	RNA-DNA hybrid ribonuclease activity
B7L65_06635	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B7L65_06640	COG0631	protein serine/threonine phosphatase activity
B7L65_06690	COG0859	PFAM glycosyl transferase family 9
B7L65_06695	COG3642	lipopolysaccharide core region biosynthetic process
B7L65_06700	COG1234	tRNA 3'-trailer cleavage
B7L65_06705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B7L65_06715	COG0315	cyclic pyranopterin monophosphate synthase activity
B7L65_06720	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B7L65_06725	COG0314	molybdopterin synthase activity
B7L65_06790	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B7L65_06795	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B7L65_06800	COG0537	adenosine 5'-monophosphoramidase activity
B7L65_06820	COG0714	Associated with various cellular activities
B7L65_06840	COG0424	maF-like protein
B7L65_06845	COG1399	metal-binding, possibly nucleic acid-binding protein
B7L65_06850	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B7L65_06855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B7L65_06870	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_06875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B7L65_06885	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B7L65_06890	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B7L65_06915	COG3829	transcription factor binding
B7L65_06935	COG3609	addiction module antidote protein, CC2985 family
B7L65_06965	COG2373	Large extracellular alpha-helical protein
B7L65_06985	COG4953	penicillin-binding protein 1C
B7L65_06995	COG0678	peroxiredoxin activity
B7L65_07015	COG0330	HflC and HflK could
B7L65_07020	COG0330	HflC and HflK could
B7L65_07030	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B7L65_07035	COG0308	aminopeptidase N
B7L65_07040	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_07045	COG1309	transcriptional regulator
B7L65_07100	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B7L65_07130	COG0328	RNA-DNA hybrid ribonuclease activity
B7L65_07130	COG0406	alpha-ribazole phosphatase activity
B7L65_07135	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B7L65_07145	COG3387	PFAM Glycoside hydrolase 15-related
B7L65_07150	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_07160	COG3537	Alpha-1,2-mannosidase
B7L65_07180	COG0492	ferredoxin-NADP+ reductase activity
B7L65_07205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B7L65_07210	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B7L65_07215	COG2080	2 iron, 2 sulfur cluster binding
B7L65_07250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B7L65_07265	COG0587	DNA-directed DNA polymerase activity
B7L65_07285	COG1297	OPT oligopeptide transporter protein
B7L65_07300	COG1506	peptidase
B7L65_07300	COG0823	Involved in the tonB-independent uptake of proteins
B7L65_07315	COG2207	Transcriptional regulator
B7L65_07315	COG1917	Cupin 2, conserved barrel domain protein
B7L65_07345	COG0753	catalase activity
B7L65_07350	COG0656	L-ascorbic acid biosynthetic process
B7L65_07360	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B7L65_07360	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B7L65_07365	COG2814	Major facilitator Superfamily
B7L65_07380	COG2194	sulfuric ester hydrolase activity
B7L65_07395	COG0745	RESPONSE REGULATOR receiver
B7L65_07400	COG0642	Histidine kinase
B7L65_07410	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B7L65_07415	COG2894	cell division
B7L65_07420	COG0850	regulation of cytokinetic process
B7L65_07435	COG4585	Histidine kinase
B7L65_07440	COG2197	response regulator
B7L65_07455	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B7L65_07485	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B7L65_07495	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B7L65_07515	COG1946	Acyl-CoA thioesterase
B7L65_07530	COG0824	Thioesterase
B7L65_07535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B7L65_07540	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B7L65_07545	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B7L65_07550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B7L65_07555	COG0268	Binds directly to 16S ribosomal RNA
B7L65_07565	COG0196	riboflavin kinase activity
B7L65_07570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B7L65_07575	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B7L65_07580	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B7L65_07595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B7L65_07600	COG1845	cytochrome c oxidase, subunit III
B7L65_07605	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B7L65_07620	COG3152	Membrane
B7L65_07630	COG2207	Transcriptional regulator
B7L65_07635	COG0326	Molecular chaperone. Has ATPase activity
B7L65_07650	COG1366	Belongs to the anti-sigma-factor antagonist family
B7L65_07655	COG1366	Belongs to the anti-sigma-factor antagonist family
B7L65_07660	COG2172	sigma factor antagonist activity
B7L65_07685	COG4771	TonB-dependent receptor
B7L65_07695	COG5507	3-demethylubiquinone-9 3-methyltransferase
B7L65_07700	COG2205	protein histidine kinase activity
B7L65_07710	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B7L65_07715	COG2205	protein histidine kinase activity
B7L65_07715	COG3437	response regulator, receiver
B7L65_07715	COG3850	Histidine kinase
B7L65_07715	COG4999	Histidine kinase
B7L65_07720	COG0784	Response regulator, receiver
B7L65_07720	COG4191	Histidine kinase
B7L65_07745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B7L65_07750	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B7L65_07760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B7L65_07765	COG0228	four-way junction DNA binding
B7L65_07770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B7L65_07775	COG0336	Belongs to the RNA methyltransferase TrmD family
B7L65_07780	COG0335	large ribosomal subunit rRNA binding
B7L65_07785	COG0534	Mate efflux family protein
B7L65_07805	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B7L65_07815	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B7L65_07840	COG3209	COG3209 Rhs family protein
B7L65_07865	COG3250	beta-galactosidase activity
B7L65_07870	COG3867	Arabinogalactan endo-beta-1,4-galactanase
B7L65_07890	COG1960	acyl-CoA dehydrogenase activity
B7L65_07895	COG1024	Enoyl-CoA hydratase
B7L65_07915	COG1024	Enoyl-CoA hydratase
B7L65_07915	COG1250	3-hydroxyacyl-CoA dehydrogenase
B7L65_07930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B7L65_07935	COG0481	GTPase activity
B7L65_07950	COG0571	ribonuclease III activity
B7L65_07955	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B7L65_07960	COG1381	Involved in DNA repair and RecF pathway recombination
B7L65_07970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B7L65_07980	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B7L65_07985	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
B7L65_07990	COG3046	protein related to deoxyribodipyrimidine photolyase
B7L65_07995	COG1472	Belongs to the glycosyl hydrolase 3 family
B7L65_08005	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B7L65_08010	COG1278	Cold shock
B7L65_08015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L65_08025	COG1201	RNA secondary structure unwinding
B7L65_08030	COG1793	dna ligase
B7L65_08040	COG1793	dna ligase
B7L65_08040	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B7L65_08075	COG0183	Belongs to the thiolase family
B7L65_08100	COG1451	nucleotide metabolic process
B7L65_08105	COG5487	UPF0391 membrane protein
B7L65_08115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B7L65_08130	COG1077	Cell shape determining protein MreB Mrl
B7L65_08135	COG1047	Peptidyl-prolyl cis-trans
B7L65_08145	COG2824	Alkylphosphonate utilization operon protein PhnA
B7L65_08155	COG1902	pentaerythritol trinitrate reductase activity
B7L65_08160	COG2814	Major facilitator Superfamily
B7L65_08190	COG0392	lysyltransferase activity
B7L65_08190	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B7L65_08200	COG0251	oxidation-reduction process
B7L65_08205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B7L65_08220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B7L65_08245	COG1595	DNA-templated transcription, initiation
B7L65_08265	COG2878	Part of a membrane complex involved in electron transport
B7L65_08275	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L65_08275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L65_08290	COG1131	(ABC) transporter
B7L65_08295	COG0346	lactoylglutathione lyase activity
B7L65_08300	COG0833	amino acid
B7L65_08305	COG2040	homocysteine
B7L65_08315	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B7L65_08335	COG1695	Transcriptional regulator
B7L65_08370	COG0825	malonyl-CoA metabolic process
B7L65_08380	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B7L65_08385	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L65_08390	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L65_08395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B7L65_08400	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L65_08415	COG0750	zinc metalloprotease
B7L65_08420	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B7L65_08425	COG0575	Belongs to the CDS family
B7L65_08430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B7L65_08435	COG0233	cytoplasmic translational termination
B7L65_08440	COG0528	UMP kinase activity
B7L65_08445	COG3706	GGDEF domain
B7L65_08445	COG0745	RESPONSE REGULATOR receiver
B7L65_08450	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B7L65_08455	COG0052	Belongs to the universal ribosomal protein uS2 family
B7L65_08490	COG0024	Methionine aminopeptidase
B7L65_08495	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B7L65_08505	COG1393	Belongs to the ArsC family
B7L65_08510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B7L65_08515	COG0367	asparagine synthase
B7L65_08525	COG4774	siderophore transport
B7L65_08540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B7L65_08570	COG1566	PFAM secretion protein HlyD family protein
B7L65_08575	COG2814	Major facilitator Superfamily
B7L65_08595	COG3104	oligopeptide transport
B7L65_08625	COG0339	signal peptide processing
B7L65_08635	COG0386	Belongs to the glutathione peroxidase family
B7L65_08690	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B7L65_08695	COG0084	hydrolase, TatD family'
B7L65_08710	COG1960	acyl-CoA dehydrogenase activity
B7L65_08730	COG0367	asparagine synthase
B7L65_08740	COG0305	Participates in initiation and elongation during chromosome replication
B7L65_08745	COG0415	Belongs to the DNA photolyase family
B7L65_08765	COG0583	DNA-binding transcription factor activity
B7L65_08800	COG3706	GGDEF domain
B7L65_08810	COG3706	GGDEF domain
B7L65_08975	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B7L65_08990	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B7L65_09000	COG0497	DNA recombination
B7L65_09005	COG1420	regulation of RNA biosynthetic process
B7L65_09010	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B7L65_09015	COG0443	Heat shock 70 kDa protein
B7L65_09020	COG0484	heat shock protein binding
B7L65_09030	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B7L65_09060	COG0583	DNA-binding transcription factor activity
B7L65_09065	COG1132	(ABC) transporter
B7L65_09100	COG2850	peptidyl-arginine hydroxylation
B7L65_09120	COG1253	flavin adenine dinucleotide binding
B7L65_09150	COG1131	(ABC) transporter
B7L65_09155	COG1725	Transcriptional regulator
B7L65_09165	COG0386	Belongs to the glutathione peroxidase family
B7L65_09180	COG2900	Belongs to the SlyX family
B7L65_09205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B7L65_09215	COG0646	methionine synthase
B7L65_09215	COG1410	methionine synthase
B7L65_09220	COG1410	methionine synthase
B7L65_09220	COG0646	methionine synthase
B7L65_09230	COG1960	acyl-CoA dehydrogenase activity
B7L65_09235	COG1960	acyl-CoA dehydrogenase activity
B7L65_09240	COG1960	acyl-CoA dehydrogenase activity
B7L65_09260	COG0557	exoribonuclease II activity
B7L65_09270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B7L65_09275	COG3706	GGDEF domain
B7L65_09280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B7L65_09290	COG0704	Plays a role in the regulation of phosphate uptake
B7L65_09295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B7L65_09300	COG0581	inorganic phosphate transmembrane transporter activity
B7L65_09305	COG0573	inorganic phosphate transmembrane transporter activity
B7L65_09310	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B7L65_09335	COG0659	secondary active sulfate transmembrane transporter activity
B7L65_09340	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B7L65_09350	COG1024	Enoyl-CoA hydratase
B7L65_09360	COG0494	nUDIX hydrolase
B7L65_09405	COG0116	Belongs to the methyltransferase superfamily
B7L65_09405	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B7L65_09410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B7L65_09435	COG2925	Exonuclease
B7L65_09445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L65_09450	COG3844	kynureninase activity
B7L65_09460	COG0662	Cupin 2, conserved barrel domain protein
B7L65_09465	COG0288	reversible hydration of carbon dioxide
B7L65_09530	COG2808	Putative FMN-binding domain
B7L65_09550	COG0017	Asparaginyl-tRNA synthetase
B7L65_09560	COG0316	Belongs to the HesB IscA family
B7L65_09565	COG0360	Binds together with S18 to 16S ribosomal RNA
B7L65_09570	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B7L65_09575	COG0359	binds to the 23S rRNA
B7L65_09585	COG3115	cell septum assembly
B7L65_09595	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B7L65_09600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B7L65_09605	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
B7L65_09620	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B7L65_09640	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B7L65_09650	COG2986	histidine ammonia-lyase
B7L65_09655	COG1228	amidohydrolase
B7L65_09700	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
B7L65_09705	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B7L65_09710	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B7L65_09715	COG1605	Chorismate mutase
B7L65_09715	COG0077	Prephenate dehydratase
B7L65_09720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B7L65_09735	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B7L65_09740	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B7L65_09745	COG0583	DNA-binding transcription factor activity
B7L65_09800	COG0556	nucleotide-excision repair
B7L65_09815	COG3505	Type IV secretory pathway VirD4
B7L65_09835	COG2948	multi-organism process
B7L65_09855	COG3702	type iv secretory pathway
B7L65_09925	COG0366	Alpha amylase catalytic
B7L65_09940	COG1082	Xylose isomerase domain protein TIM barrel
B7L65_09965	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B7L65_09970	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B7L65_09975	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B7L65_09980	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B7L65_09985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B7L65_09990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L65_09990	COG0072	phenylalanine-tRNA ligase activity
B7L65_09995	COG0776	regulation of translation
B7L65_10040	COG0438	transferase activity, transferring glycosyl groups
B7L65_10045	COG0438	transferase activity, transferring glycosyl groups
B7L65_10080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B7L65_10085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L65_10090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B7L65_10110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B7L65_10120	COG1960	acyl-CoA dehydrogenase activity
B7L65_10135	COG3040	lipid binding
B7L65_10150	COG0322	excinuclease ABC activity
B7L65_10165	COG4191	Histidine kinase
B7L65_10165	COG0784	Response regulator, receiver
B7L65_10170	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
B7L65_10175	COG1194	a g-specific adenine glycosylase
B7L65_10185	COG0552	protein localization to endoplasmic reticulum
B7L65_10195	COG3938	Belongs to the proline racemase family
B7L65_10200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L65_10215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B7L65_10225	COG0006	proline dipeptidase activity
B7L65_10240	COG0531	amino acid
B7L65_10325	COG0326	Molecular chaperone. Has ATPase activity
B7L65_10330	COG0742	ribosomal rna small subunit methyltransferase
B7L65_10335	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B7L65_10350	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B7L65_10355	COG0405	Gamma-glutamyltransferase
B7L65_10360	COG3291	Pkd domain containing protein
B7L65_10365	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B7L65_10400	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B7L65_10405	COG0343	queuine tRNA-ribosyltransferase activity
B7L65_10410	COG1862	Preprotein translocase
B7L65_10420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B7L65_10490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B7L65_10490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B7L65_10495	COG1105	Belongs to the carbohydrate kinase PfkB family
B7L65_10500	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7L65_10500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B7L65_10505	COG1609	Transcriptional regulator
B7L65_10510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L65_10515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L65_10525	COG2902	Dehydrogenase
B7L65_10535	COG0477	Major facilitator Superfamily
B7L65_10545	COG5002	protein histidine kinase activity
B7L65_10545	COG2205	protein histidine kinase activity
B7L65_10545	COG0784	Response regulator, receiver
B7L65_10550	COG2733	membrane
B7L65_10580	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B7L65_10585	COG0243	molybdopterin cofactor binding
B7L65_10595	COG0477	Major facilitator Superfamily
B7L65_10600	COG2703	oxygen carrier activity
B7L65_10605	COG0745	RESPONSE REGULATOR receiver
B7L65_10605	COG3706	GGDEF domain
B7L65_10610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L65_10615	COG0174	glutamine synthetase
B7L65_10620	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B7L65_10635	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B7L65_10655	COG3842	ATPase activity
B7L65_10660	COG1176	ABC-type spermidine putrescine transport system, permease component I
B7L65_10665	COG1177	transmembrane transport
B7L65_10670	COG1012	belongs to the aldehyde dehydrogenase family
B7L65_10685	COG4535	Mg2 and Co2 transporter CorC
B7L65_10695	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B7L65_10705	COG1702	phosphate starvation-inducible protein PhoH
B7L65_10710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B7L65_10725	COG0741	lytic transglycosylase activity
B7L65_10735	COG0723	plastoquinol--plastocyanin reductase activity
B7L65_10740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B7L65_10745	COG2857	Cytochrome c1
B7L65_10750	COG0625	glutathione transferase activity
B7L65_10755	COG2969	positive regulation of protein catabolic process
B7L65_10775	COG1201	RNA secondary structure unwinding
B7L65_10780	COG2094	Belongs to the DNA glycosylase MPG family
B7L65_10785	COG0840	transmembrane signaling receptor activity
B7L65_10790	COG0835	chemotaxis
B7L65_10995	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B7L65_11005	COG1570	exodeoxyribonuclease VII activity
B7L65_11010	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B7L65_11015	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B7L65_11015	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B7L65_11020	COG0802	atpase or kinase
B7L65_11025	COG0860	N-Acetylmuramoyl-L-alanine amidase
B7L65_11030	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B7L65_11055	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_11060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L65_11065	COG0501	Belongs to the peptidase M48B family
B7L65_11075	COG2081	HI0933 family
B7L65_11080	COG4681	YaeQ
B7L65_11090	COG0625	glutathione transferase activity
B7L65_11100	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B7L65_11105	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B7L65_11110	COG0513	Belongs to the DEAD box helicase family
B7L65_11140	COG0483	inositol monophosphate 1-phosphatase activity
B7L65_11155	COG5001	Diguanylate cyclase
B7L65_11155	COG3300	MHYT domain
B7L65_11160	COG1509	lysine 2,3-aminomutase activity
B7L65_11165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B7L65_11175	COG0402	S-adenosylhomocysteine deaminase activity
B7L65_11180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B7L65_11240	COG4302	ethanolamine ammonia-lyase activity
B7L65_11270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B7L65_11275	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B7L65_11280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B7L65_11290	COG2166	iron-sulfur cluster assembly
B7L65_11295	COG0215	cysteine-tRNA ligase activity
B7L65_11305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B7L65_11310	COG0137	argininosuccinate synthase activity
B7L65_11325	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B7L65_11335	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B7L65_11340	COG0165	Argininosuccinate lyase
B7L65_11350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B7L65_11355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B7L65_11385	COG1294	oxidase, subunit
B7L65_11395	COG4988	ABC transporter
B7L65_11400	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B7L65_11405	COG1278	Cold shock
B7L65_11410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B7L65_11430	COG1138	Cytochrome C-type biogenesis protein
B7L65_11435	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B7L65_11455	COG4133	protoheme IX ABC transporter activity
B7L65_11460	COG0436	Aminotransferase
B7L65_11480	COG1187	pseudouridine synthase activity
B7L65_11485	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B7L65_11490	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B7L65_11495	COG2350	Protein conserved in bacteria
B7L65_11525	COG1175	transmembrane transport
B7L65_11530	COG0395	ABC-type sugar transport system, permease component
B7L65_11555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B7L65_11560	COG2957	Belongs to the agmatine deiminase family
B7L65_11575	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B7L65_11580	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B7L65_11585	COG0539	negative regulation of cytoplasmic translation
B7L65_11590	COG0776	regulation of translation
B7L65_11600	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B7L65_11605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B7L65_11615	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B7L65_11620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B7L65_11620	COG0475	glutathione-regulated potassium exporter activity
B7L65_11630	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B7L65_11640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B7L65_11640	COG0519	Catalyzes the synthesis of GMP from XMP
B7L65_11645	COG0582	viral genome integration into host DNA
B7L65_11690	COG2003	Belongs to the UPF0758 family
B7L65_11710	COG2084	Dehydrogenase
B7L65_11790	COG0210	DNA helicase
B7L65_11840	COG3002	Belongs to the UPF0753 family
B7L65_11875	COG0641	radical SAM
B7L65_11890	COG0643	Histidine kinase
B7L65_11890	COG2198	Histidine kinase
B7L65_11910	COG0455	bacterial-type flagellum organization
B7L65_11920	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B7L65_11935	COG5001	Diguanylate cyclase
B7L65_11935	COG3300	MHYT domain
B7L65_11945	COG3300	MHYT domain
B7L65_11945	COG5001	Diguanylate cyclase
B7L65_11950	COG1684	flagellar biosynthetic protein fliR
B7L65_11955	COG1987	bacterial-type flagellum assembly
B7L65_11965	COG3190	flagellar
B7L65_12015	COG1677	Flagellar hook-basal body complex protein FliE
B7L65_12045	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_12050	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_12055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B7L65_12070	COG2204	response regulator
B7L65_12075	COG2201	protein-glutamate methylesterase activity
B7L65_12105	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B7L65_12110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B7L65_12115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B7L65_12125	COG3951	Flagellar rod assembly protein muramidase FlgJ
B7L65_12125	COG1705	Flagellar rod assembly protein muramidase FlgJ
B7L65_12130	COG1706	bacterial-type flagellum-dependent cell motility
B7L65_12135	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B7L65_12140	COG4786	Flagellar basal body rod
B7L65_12150	COG4787	bacterial-type flagellum-dependent cell motility
B7L65_12155	COG1749	Flagellar hook protein flgE
B7L65_12160	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B7L65_12165	COG1558	bacterial-type flagellum-dependent cell motility
B7L65_12175	COG0835	chemotaxis
B7L65_12175	COG0784	Response regulator, receiver
B7L65_12195	COG5002	protein histidine kinase activity
B7L65_12225	COG2915	High frequency lysogenization protein hflD homolog
B7L65_12230	COG0482	sulfurtransferase activity
B7L65_12240	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B7L65_12245	COG0542	response to heat
B7L65_12250	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B7L65_12255	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B7L65_12265	COG0492	ferredoxin-NADP+ reductase activity
B7L65_12270	COG1674	ftsk spoiiie
B7L65_12280	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B7L65_12290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B7L65_12295	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B7L65_12305	COG0183	Belongs to the thiolase family
B7L65_12310	COG1024	Enoyl-CoA hydratase
B7L65_12310	COG1250	3-hydroxyacyl-CoA dehydrogenase
B7L65_12320	COG0105	UTP biosynthetic process
B7L65_12325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B7L65_12335	COG1426	Protein conserved in bacteria
B7L65_12345	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B7L65_12350	COG1160	GTP binding
B7L65_12355	COG0303	'Molybdopterin
B7L65_12360	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B7L65_12395	COG0708	Exodeoxyribonuclease III
B7L65_12405	COG0303	'Molybdopterin
B7L65_12410	COG0746	molybdenum cofactor guanylyltransferase activity
B7L65_12425	COG1914	H( )-stimulated, divalent metal cation uptake system
B7L65_12430	COG1321	iron dependent repressor
B7L65_12435	COG0590	tRNA wobble adenosine to inosine editing
B7L65_12440	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B7L65_12445	COG0668	transmembrane transport
B7L65_12455	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B7L65_12470	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_12475	COG1183	phosphatidylcholine synthase activity
B7L65_12485	COG3243	poly(R)-hydroxyalkanoic acid synthase
B7L65_12500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L65_12500	COG0723	plastoquinol--plastocyanin reductase activity
B7L65_12510	COG2183	response to ionizing radiation
B7L65_12515	COG0784	Response regulator, receiver
B7L65_12515	COG2205	protein histidine kinase activity
B7L65_12590	COG0800	Aldolase
B7L65_12595	COG0129	dihydroxy-acid dehydratase activity
B7L65_12600	COG0363	glucosamine-6-phosphate deaminase activity
B7L65_12605	COG0837	glucose binding
B7L65_12610	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B7L65_12635	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B7L65_12650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B7L65_12655	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B7L65_12665	COG4591	ABC-type transport system involved in lipoprotein release permease component
B7L65_12670	COG1136	(ABC) transporter
B7L65_12685	COG0811	peptide transport
B7L65_12695	COG1132	(ABC) transporter
B7L65_12700	COG1663	tetraacyldisaccharide 4'-kinase activity
B7L65_12705	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B7L65_12710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B7L65_12720	COG0322	excinuclease ABC activity
B7L65_12725	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B7L65_12760	COG1396	sequence-specific DNA binding
B7L65_12765	COG0583	DNA-binding transcription factor activity
B7L65_12910	COG2003	Belongs to the UPF0758 family
B7L65_13105	COG0270	DNA (cytosine-5-)-methyltransferase activity
B7L65_13115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L65_13120	COG0629	single-stranded DNA binding
B7L65_13155	COG1192	Involved in chromosome partitioning
B7L65_13300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B7L65_13305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B7L65_13320	COG0582	viral genome integration into host DNA
B7L65_13330	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B7L65_13360	COG1530	ribonuclease E activity
B7L65_13370	COG3064	Membrane
B7L65_13375	COG0428	transporter
B7L65_13385	COG2154	pterin-4-alpha-carbinolamine dehydratase
B7L65_13390	COG0316	Belongs to the HesB IscA family
B7L65_13390	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B7L65_13435	COG1073	alpha beta
B7L65_13435	COG2226	methyltransferase
B7L65_13445	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_13595	COG1238	metal cluster binding
B7L65_13630	COG3279	Response regulator of the LytR AlgR family
B7L65_13680	COG4566	intracellular signal transduction
B7L65_13690	COG5001	Diguanylate cyclase
B7L65_13710	COG3685	Protein conserved in bacteria
B7L65_13735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B7L65_13735	COG1648	precorrin-2 dehydrogenase activity
B7L65_13750	COG2814	Major facilitator Superfamily
B7L65_13765	COG1335	isochorismatase
B7L65_13780	COG2197	response regulator
B7L65_13795	COG0583	DNA-binding transcription factor activity
B7L65_13800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B7L65_13805	COG3002	Belongs to the UPF0753 family
B7L65_13815	COG1396	sequence-specific DNA binding
B7L65_13820	COG5489	Protein of unknown function (DUF736)
B7L65_13825	COG2003	Belongs to the UPF0758 family
B7L65_13915	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B7L65_13920	COG1360	Flagellar Motor Protein
B7L65_13925	COG1192	Involved in chromosome partitioning
B7L65_13930	COG0835	chemotaxis
B7L65_13940	COG0745	RESPONSE REGULATOR receiver
B7L65_13945	COG2198	Histidine kinase
B7L65_13945	COG0643	Histidine kinase
B7L65_13950	COG0840	transmembrane signaling receptor activity
B7L65_13960	COG0840	transmembrane signaling receptor activity
B7L65_13960	COG0840	transmembrane signaling receptor activity
B7L65_13965	COG0840	transmembrane signaling receptor activity
B7L65_13980	COG0840	transmembrane signaling receptor activity
B7L65_13985	COG0840	transmembrane signaling receptor activity
B7L65_13990	COG0840	transmembrane signaling receptor activity
B7L65_13995	COG0840	transmembrane signaling receptor activity
B7L65_14005	COG0840	transmembrane signaling receptor activity
B7L65_14010	COG0840	transmembrane signaling receptor activity
B7L65_14015	COG0840	transmembrane signaling receptor activity
B7L65_14020	COG0840	transmembrane signaling receptor activity
B7L65_14025	COG0840	transmembrane signaling receptor activity
B7L65_14040	COG0835	chemotaxis
B7L65_14050	COG0840	transmembrane signaling receptor activity
B7L65_14060	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B7L65_14065	COG2201	protein-glutamate methylesterase activity
B7L65_14075	COG2267	carboxylic ester hydrolase activity
B7L65_14105	COG0318	PFAM AMP-dependent synthetase and ligase
B7L65_14110	COG1024	Enoyl-CoA hydratase
B7L65_14115	COG2205	protein histidine kinase activity
B7L65_14115	COG2198	Histidine kinase
B7L65_14115	COG0784	Response regulator, receiver
B7L65_14125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B7L65_14135	COG3279	Response regulator of the LytR AlgR family
B7L65_14175	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B7L65_14185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B7L65_14190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B7L65_14200	COG0505	Belongs to the CarA family
B7L65_14205	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B7L65_14210	COG2258	MOSC domain
B7L65_14215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B7L65_14260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B7L65_14280	COG0277	FAD linked oxidase domain protein
B7L65_14285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B7L65_14295	COG0531	amino acid
B7L65_14300	COG0531	amino acid
B7L65_14305	COG0235	Class ii aldolase
B7L65_14310	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B7L65_14315	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
B7L65_14330	COG0140	phosphoribosyl-ATP diphosphatase activity
B7L65_14330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B7L65_14335	COG0107	imidazoleglycerol-phosphate synthase activity
B7L65_14340	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B7L65_14345	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B7L65_14350	COG0131	Imidazoleglycerol-phosphate dehydratase
B7L65_14350	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B7L65_14355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B7L65_14360	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B7L65_14365	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B7L65_14375	COG0124	histidyl-tRNA synthetase
B7L65_14380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B7L65_14455	COG3210	domain, Protein
B7L65_14470	COG1649	PFAM Uncharacterised BCR, COG1649
B7L65_14470	COG0726	polysaccharide deacetylase
B7L65_14475	COG1215	transferase activity, transferring glycosyl groups
B7L65_14490	COG1012	belongs to the aldehyde dehydrogenase family
B7L65_14510	COG0167	dihydroorotate dehydrogenase activity
B7L65_14515	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B7L65_14520	COG0697	spore germination
B7L65_14530	COG1794	racemase activity, acting on amino acids and derivatives
B7L65_14545	COG0671	phosphoesterase, PA-phosphatase related
B7L65_14550	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B7L65_14565	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B7L65_14570	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L65_14580	COG2203	Gaf domain
B7L65_14580	COG4251	negative regulation of phosphorylation
B7L65_14580	COG5001	Diguanylate cyclase
B7L65_14580	COG3706	GGDEF domain
B7L65_14595	COG1472	Belongs to the glycosyl hydrolase 3 family
B7L65_14620	COG0166	Belongs to the GPI family
B7L65_14625	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B7L65_14630	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B7L65_14635	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B7L65_14655	COG1469	GTP cyclohydrolase I activity
B7L65_14660	COG0860	N-Acetylmuramoyl-L-alanine amidase
B7L65_14690	COG0477	Major facilitator Superfamily
B7L65_14695	COG2115	Belongs to the xylose isomerase family
B7L65_14700	COG1070	Carbohydrate kinase
B7L65_14710	COG1501	Belongs to the glycosyl hydrolase 31 family
B7L65_14750	COG0800	Aldolase
B7L65_14755	COG4948	Mandelate Racemase Muconate Lactonizing
B7L65_14765	COG3734	2-keto-3-deoxy-galactonokinase
B7L65_14770	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B7L65_14780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B7L65_14795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B7L65_14800	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B7L65_14815	COG0351	phosphomethylpyrimidine kinase
B7L65_14815	COG0352	thiamine-phosphate diphosphorylase activity
B7L65_14840	COG0583	DNA-binding transcription factor activity
B7L65_14845	COG1741	Belongs to the pirin family
B7L65_14865	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B7L65_14870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B7L65_14875	COG2137	regulation of response to DNA damage stimulus
B7L65_14885	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B7L65_14890	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B7L65_14900	COG1546	Belongs to the CinA family
B7L65_14905	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B7L65_14910	COG1923	regulation of RNA biosynthetic process
B7L65_14915	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B7L65_14920	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B7L65_14925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B7L65_14930	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B7L65_14935	COG1534	Rna-binding protein
B7L65_14950	COG1238	metal cluster binding
B7L65_14955	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B7L65_14960	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B7L65_14965	COG2840	Smr protein MutS2
B7L65_14970	COG0585	pseudouridine synthase activity
B7L65_14975	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B7L65_14980	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B7L65_14985	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B7L65_14990	COG0148	phosphopyruvate hydratase activity
B7L65_15000	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B7L65_15005	COG0504	CTP synthase activity
B7L65_15030	COG0306	phosphate transporter
B7L65_15045	COG1253	flavin adenine dinucleotide binding
B7L65_15060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B7L65_15065	COG0477	Major facilitator Superfamily
B7L65_15075	COG1136	(ABC) transporter
B7L65_15090	COG0438	transferase activity, transferring glycosyl groups
B7L65_15100	COG2264	protein methyltransferase activity
B7L65_15135	COG2244	polysaccharide biosynthetic process
B7L65_15190	COG1595	DNA-templated transcription, initiation
B7L65_15205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B7L65_15215	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B7L65_15225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B7L65_15240	COG0784	Response regulator, receiver
B7L65_15240	COG4191	Histidine kinase
B7L65_15245	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
B7L65_15255	COG5002	protein histidine kinase activity
B7L65_15255	COG2205	protein histidine kinase activity
B7L65_15255	COG0784	Response regulator, receiver
B7L65_15280	COG0840	transmembrane signaling receptor activity
B7L65_15350	COG3275	phosphorelay sensor kinase activity
B7L65_15355	COG1611	Belongs to the LOG family
B7L65_15370	COG2095	MarC family integral membrane protein
B7L65_15380	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B7L65_15385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B7L65_15415	COG1185	polyribonucleotide nucleotidyltransferase activity
B7L65_15420	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B7L65_15425	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B7L65_15430	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B7L65_15435	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B7L65_15440	COG0195	Participates in both transcription termination and antitermination
B7L65_15445	COG0779	Required for maturation of 30S ribosomal subunits
B7L65_15455	COG1007	ATP synthesis coupled electron transport
B7L65_15470	COG0713	ATP synthesis coupled electron transport
B7L65_15480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B7L65_15485	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B7L65_15495	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B7L65_15500	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
B7L65_15505	COG0649	NAD binding
B7L65_15510	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B7L65_15515	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B7L65_15520	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B7L65_15535	COG0149	triose-phosphate isomerase activity
B7L65_15540	COG0300	oxidoreductase activity
B7L65_15570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B7L65_15575	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B7L65_15580	COG0159	tryptophan synthase activity
B7L65_15590	COG0133	tryptophan synthase activity
B7L65_15600	COG0135	phosphoribosylanthranilate isomerase activity
B7L65_15605	COG0101	tRNA pseudouridine synthase activity
B7L65_15625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B7L65_15630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B7L65_15635	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B7L65_15640	COG2890	protein-(glutamine-N5) methyltransferase activity
B7L65_15650	COG0688	phosphatidylethanolamine metabolic process
B7L65_15665	COG0433	COG0433 Predicted ATPase
B7L65_15670	COG0494	nUDIX hydrolase
B7L65_15685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B7L65_15690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B7L65_15710	COG0717	Belongs to the dCTP deaminase family
B7L65_15720	COG0489	protein tyrosine kinase activity
B7L65_15740	COG3590	peptidase
B7L65_15750	COG3590	peptidase
B7L65_15770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B7L65_15775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L65_15780	COG2311	Membrane
B7L65_15785	COG1047	Peptidyl-prolyl cis-trans
B7L65_15790	COG0791	NLP P60 protein
B7L65_15795	COG0791	NLP P60 protein
B7L65_15805	COG4106	trans-aconitate 2-methyltransferase activity
B7L65_15810	COG1301	dicarboxylic acid transport
B7L65_15815	COG1785	Belongs to the alkaline phosphatase family
B7L65_15825	COG0037	tRNA processing
B7L65_15830	COG1722	exodeoxyribonuclease VII activity
B7L65_15835	COG0142	geranyltranstransferase activity
B7L65_15840	COG4104	PAAR repeat-containing protein
B7L65_15850	COG0312	modulator of DNA gyrase
B7L65_15855	COG3028	Belongs to the UPF0307 family
B7L65_15860	COG0312	modulator of DNA gyrase
B7L65_15870	COG3164	Protein of unknown function
B7L65_15875	COG1530	ribonuclease E activity
B7L65_15880	COG0424	maF-like protein
B7L65_15885	COG2968	Membrane
B7L65_15900	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B7L65_15915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B7L65_15930	COG0495	leucyl-tRNA aminoacylation
B7L65_15940	COG3118	belongs to the thioredoxin family
B7L65_15970	COG2155	Conserved Protein
B7L65_15975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B7L65_16015	COG1132	(ABC) transporter
B7L65_16045	COG1538	Outer membrane efflux protein
B7L65_16050	COG0745	RESPONSE REGULATOR receiver
B7L65_16055	COG5002	protein histidine kinase activity
B7L65_16055	COG5000	phosphorelay sensor kinase activity
B7L65_16060	COG0475	glutathione-regulated potassium exporter activity
B7L65_16065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B7L65_16070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B7L65_16090	COG3706	GGDEF domain
B7L65_16090	COG0745	RESPONSE REGULATOR receiver
B7L65_16095	COG1187	pseudouridine synthase activity
B7L65_16100	COG5001	Diguanylate cyclase
B7L65_16100	COG5002	protein histidine kinase activity
B7L65_16150	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B7L65_16220	COG0667	Aldo Keto reductase
B7L65_16225	COG2814	Major facilitator Superfamily
B7L65_16230	COG0583	DNA-binding transcription factor activity
B7L65_16240	COG2207	Transcriptional regulator
B7L65_16250	COG1309	transcriptional regulator
B7L65_16255	COG1538	Outer membrane efflux protein
B7L65_16260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L65_16275	COG0735	belongs to the Fur family
B7L65_16280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L65_16305	COG4452	Inner membrane protein CreD
B7L65_16315	COG2205	protein histidine kinase activity
B7L65_16320	COG0745	RESPONSE REGULATOR receiver
B7L65_16325	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B7L65_16335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B7L65_16385	COG0643	Histidine kinase
B7L65_16385	COG2198	Histidine kinase
B7L65_16390	COG0840	transmembrane signaling receptor activity
B7L65_16395	COG0835	chemotaxis
B7L65_16400	COG2199	diguanylate cyclase activity
B7L65_16400	COG2200	EAL domain
B7L65_16400	COG2202	Pas domain
B7L65_16405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B7L65_16410	COG2201	protein-glutamate methylesterase activity
B7L65_16415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L65_16420	COG3590	peptidase
B7L65_16430	COG0588	phosphoglycerate mutase activity
B7L65_16435	COG1515	deoxyribonuclease V activity
B7L65_16445	COG1741	Belongs to the pirin family
B7L65_16460	COG1741	Belongs to the pirin family
B7L65_16465	COG1966	Carbon starvation protein
B7L65_16470	COG2879	small protein
B7L65_16520	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B7L65_16525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B7L65_16530	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B7L65_16535	COG2080	2 iron, 2 sulfur cluster binding
B7L65_16545	COG2203	Gaf domain
B7L65_16545	COG5001	Diguanylate cyclase
B7L65_16545	COG3706	GGDEF domain
B7L65_16545	COG4251	negative regulation of phosphorylation
B7L65_16550	COG0629	single-stranded DNA binding
B7L65_16555	COG0142	geranyltranstransferase activity
B7L65_16570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B7L65_16585	COG0527	aspartate kinase activity
B7L65_16590	COG0384	phenazine biosynthesis protein PhzF
B7L65_16595	COG0384	phenazine biosynthesis protein PhzF
B7L65_16605	COG1764	response to oxidative stress
B7L65_16610	COG0540	Belongs to the ATCase OTCase family
B7L65_16615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B7L65_16620	COG1678	Uncharacterized ACR, COG1678
B7L65_16630	COG0519	Catalyzes the synthesis of GMP from XMP
B7L65_16640	COG5297	Belongs to the glycosyl hydrolase family 6
B7L65_16655	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B7L65_16670	COG0739	heme binding
B7L65_16690	COG0693	protein deglycase activity
B7L65_16700	COG1959	2 iron, 2 sulfur cluster binding
B7L65_16705	COG0719	Fe-S assembly protein
B7L65_16710	COG0396	ATPase activity
B7L65_16715	COG0719	Fe-S assembly protein
B7L65_16720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B7L65_16735	COG4774	siderophore transport
B7L65_16740	COG3128	pkhd-type hydroxylase
B7L65_16765	COG1477	protein flavinylation
B7L65_16770	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B7L65_16785	COG1555	photosystem II stabilization
B7L65_16790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B7L65_16800	COG3178	'Phosphotransferase
B7L65_16805	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B7L65_16815	COG0628	permease
B7L65_16825	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B7L65_16835	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B7L65_16855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B7L65_16860	COG0271	Belongs to the BolA IbaG family
B7L65_16870	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B7L65_16880	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
B7L65_16885	COG1137	ATPase activity
B7L65_16900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7L65_16905	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B7L65_16910	COG1660	Displays ATPase and GTPase activities
B7L65_16920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7L65_16925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B7L65_16935	COG2239	Acts as a magnesium transporter
B7L65_16950	COG1294	oxidase, subunit
B7L65_16955	COG1271	oxidase subunit
B7L65_16965	COG1113	amino acid transport
B7L65_16995	COG2197	response regulator
B7L65_17000	COG0531	amino acid
B7L65_17035	COG1234	tRNA 3'-trailer cleavage
B7L65_17075	COG2814	Major facilitator Superfamily
B7L65_17085	COG0754	glutathionylspermidine amidase activity
B7L65_17110	COG1842	Phage shock protein A
B7L65_17120	COG0259	pyridoxamine-phosphate oxidase activity
B7L65_17125	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B7L65_17130	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B7L65_17140	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B7L65_17215	COG0477	Major facilitator Superfamily
B7L65_17235	COG0784	Response regulator, receiver
B7L65_17235	COG2205	protein histidine kinase activity
B7L65_17235	COG2198	Histidine kinase
B7L65_17240	COG2353	YceI-like domain
B7L65_17260	COG1760	l-serine dehydratase
B7L65_17275	COG0460	homoserine dehydrogenase
B7L65_17275	COG0527	aspartate kinase activity
B7L65_17280	COG0626	cystathionine gamma-synthase activity
B7L65_17285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B7L65_17290	COG0739	heme binding
B7L65_17295	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B7L65_17300	COG1272	protein, Hemolysin III
B7L65_17305	COG2982	Protein involved in outer membrane biogenesis
B7L65_17310	COG0516	GMP reductase activity
B7L65_17310	COG0517	IMP dehydrogenase activity
B7L65_17315	COG0463	Glycosyl transferase, family 2
B7L65_17320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B7L65_17325	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B7L65_17335	COG4771	TonB-dependent receptor
B7L65_17345	COG1309	transcriptional regulator
B7L65_17350	COG2267	carboxylic ester hydrolase activity
B7L65_17355	COG1960	acyl-CoA dehydrogenase activity
B7L65_17380	COG0509	glycine decarboxylation via glycine cleavage system
B7L65_17385	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B7L65_17395	COG0330	HflC and HflK could
B7L65_17400	COG1742	UPF0060 membrane protein
B7L65_17405	COG3956	TIGRFAM MazG family protein
B7L65_17415	COG0494	nUDIX hydrolase
B7L65_17425	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B7L65_17430	COG0837	glucose binding
B7L65_17445	COG1388	LysM domain
B7L65_17445	COG3858	chitin binding
B7L65_17450	COG3525	Glycosyl hydrolase, family 20, catalytic domain
B7L65_17460	COG1472	Belongs to the glycosyl hydrolase 3 family
B7L65_17475	COG0531	amino acid
B7L65_17485	COG1486	melibiose metabolic process
B7L65_17495	COG3537	Alpha-1,2-mannosidase
B7L65_17535	COG3142	Participates in the control of copper homeostasis
B7L65_17540	COG1446	asparaginase
B7L65_17580	COG0840	transmembrane signaling receptor activity
B7L65_17600	COG0189	ligase activity
B7L65_17610	COG1397	ADP-ribosylglycohydrolase
B7L65_17620	COG1199	ATP-dependent helicase activity
B7L65_17630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B7L65_17635	COG1215	transferase activity, transferring glycosyl groups
B7L65_17655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B7L65_17665	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B7L65_17670	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
B7L65_17675	COG0535	radical SAM domain protein
B7L65_17680	COG0535	radical SAM domain protein
B7L65_17695	COG0837	glucose binding
B7L65_17710	COG1643	Atp-dependent helicase
B7L65_17715	COG0783	Belongs to the Dps family
B7L65_17725	COG0514	ATP-dependent DNA helicase (RecQ)
B7L65_17755	COG0840	transmembrane signaling receptor activity
B7L65_17790	COG3920	Histidine kinase
B7L65_17795	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B7L65_17805	COG0602	queuosine metabolic process
B7L65_17815	COG2885	chlorophyll binding
B7L65_17820	COG0823	Involved in the tonB-independent uptake of proteins
B7L65_17830	COG0848	biopolymer transport protein
B7L65_17840	COG0824	Thioesterase
B7L65_17845	COG2255	four-way junction helicase activity
B7L65_17855	COG3158	transport of potassium into the cell
B7L65_17860	COG0632	four-way junction helicase activity
B7L65_17865	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B7L65_17870	COG0217	transcriptional regulatory protein
B7L65_17885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B7L65_17900	COG0477	Major facilitator Superfamily
B7L65_17945	COG0488	(ABC) transporter
B7L65_17985	COG4651	solute:proton antiporter activity
B7L65_17985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B7L65_18010	COG4772	TonB-dependent receptor
B7L65_18020	COG4264	IucA IucC family
B7L65_18035	COG0019	diaminopimelate decarboxylase activity
B7L65_18060	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B7L65_18070	COG1492	cobalamin metabolic process
B7L65_18080	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B7L65_18100	COG4206	TonB-dependent receptor
B7L65_18105	COG0542	response to heat
B7L65_18110	COG1116	anion transmembrane transporter activity
B7L65_18115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L65_18120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B7L65_18125	COG0667	Aldo Keto reductase
B7L65_18135	COG4771	TonB-dependent receptor
B7L65_18140	COG2827	Endonuclease containing a URI domain
B7L65_18180	COG1877	trehalose-phosphatase activity
B7L65_18185	COG3387	PFAM Glycoside hydrolase 15-related
B7L65_18205	COG0840	transmembrane signaling receptor activity
B7L65_18210	COG3011	Protein conserved in bacteria
B7L65_18225	COG0564	pseudouridine synthase activity
B7L65_18230	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B7L65_18240	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B7L65_18240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B7L65_18265	COG2951	lytic endotransglycosylase activity
B7L65_18270	COG4644	lycopene metabolic process
B7L65_18355	COG0473	3-isopropylmalate dehydrogenase activity
B7L65_18370	COG4783	chaperone-mediated protein folding
B7L65_18385	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B7L65_18395	COG0438	transferase activity, transferring glycosyl groups
B7L65_18400	COG0671	phosphoesterase, PA-phosphatase related
B7L65_18405	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L65_18415	COG3291	Pkd domain containing protein
B7L65_18425	COG2833	Protein of unknown function (DUF455)
B7L65_18445	COG0285	dihydrofolate synthase activity
B7L65_18450	COG0406	alpha-ribazole phosphatase activity
B7L65_18480	COG1063	alcohol dehydrogenase
B7L65_18490	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B7L65_18495	COG4208	sulfate ABC transporter
B7L65_18500	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
B7L65_18505	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
B7L65_18510	COG0156	8-amino-7-oxononanoate synthase activity
B7L65_18540	COG0604	alcohol dehydrogenase
B7L65_18545	COG0446	pyridine nucleotide-disulphide oxidoreductase
B7L65_18545	COG1902	pentaerythritol trinitrate reductase activity
B7L65_18565	COG0625	glutathione transferase activity
B7L65_18570	COG0039	L-malate dehydrogenase activity
B7L65_18575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B7L65_18590	COG0154	amidase activity
B7L65_18600	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B7L65_18620	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B7L65_18625	COG0203	ribosomal protein L17
B7L65_18630	COG0202	RNA polymerase activity
B7L65_18635	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B7L65_18640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B7L65_18645	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B7L65_18650	COG0201	protein transport
B7L65_18655	COG0200	Binds to the 23S rRNA
B7L65_18660	COG1841	ribosomal large subunit assembly
B7L65_18665	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B7L65_18670	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B7L65_18675	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B7L65_18680	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B7L65_18685	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B7L65_18690	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B7L65_18695	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B7L65_18700	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B7L65_18705	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B7L65_18710	COG0255	Belongs to the universal ribosomal protein uL29 family
B7L65_18715	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B7L65_18720	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B7L65_18725	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B7L65_18730	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B7L65_18735	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B7L65_18740	COG0089	rRNA binding
B7L65_18745	COG0088	Forms part of the polypeptide exit tunnel
B7L65_18750	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B7L65_18755	COG0051	transcription antitermination factor activity, RNA binding
B7L65_18760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B7L65_18765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B7L65_18770	COG0049	tRNA binding
B7L65_18775	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B7L65_18780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B7L65_18785	COG0085	RNA polymerase activity
B7L65_18790	COG0222	ribosome binding
B7L65_18795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B7L65_18800	COG0081	regulation of translation
B7L65_18805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B7L65_18810	COG0250	Participates in transcription elongation, termination and antitermination
B7L65_18815	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B7L65_18825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B7L65_18845	COG0012	GTP binding
B7L65_18850	COG0193	aminoacyl-tRNA hydrolase activity
B7L65_18855	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B7L65_18860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B7L65_18870	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B7L65_18875	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B7L65_18890	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B7L65_18900	COG0521	Mo-molybdopterin cofactor biosynthetic process
B7L65_18920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B7L65_18925	COG1295	ribonuclease BN
B7L65_18950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B7L65_18955	COG1404	Belongs to the peptidase S8 family
B7L65_18960	COG1404	Belongs to the peptidase S8 family
B7L65_18965	COG1404	Belongs to the peptidase S8 family
B7L65_18970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B7L65_18985	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B7L65_18990	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B7L65_19010	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B7L65_19040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B7L65_19040	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B7L65_19060	COG2890	protein-(glutamine-N5) methyltransferase activity
B7L65_19070	COG3634	alkyl hydroperoxide reductase activity
B7L65_19075	COG0583	DNA-binding transcription factor activity
B7L65_19085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B7L65_19090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B7L65_19100	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B7L65_19110	COG2197	response regulator
B7L65_19115	COG5002	protein histidine kinase activity
B7L65_19115	COG0784	Response regulator, receiver
B7L65_19115	COG2205	protein histidine kinase activity
B7L65_19120	COG3706	GGDEF domain
B7L65_19120	COG0745	RESPONSE REGULATOR receiver
B7L65_19135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L65_19145	COG0697	spore germination
B7L65_19170	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
B7L65_19185	COG3386	PFAM SMP-30 Gluconolaconase
B7L65_19205	COG1024	Enoyl-CoA hydratase
B7L65_19220	COG0583	DNA-binding transcription factor activity
B7L65_19225	COG3384	dioxygenase
B7L65_19255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L65_19260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L65_19275	COG2096	Adenosyltransferase
B7L65_19280	COG0123	including yeast histone deacetylase and acetoin utilization protein
B7L65_19295	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B7L65_19300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B7L65_19305	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B7L65_19310	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B7L65_19315	COG2967	ApaG domain
B7L65_19320	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B7L65_19340	COG0747	negative chemotaxis
B7L65_19365	COG0431	NADPH-dependent FMN reductase
B7L65_19370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B7L65_19380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L65_19385	COG1116	anion transmembrane transporter activity
B7L65_19395	COG3829	transcription factor binding
B7L65_19410	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B7L65_19415	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B7L65_19435	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B7L65_19450	COG0642	Histidine kinase
B7L65_19465	COG4181	ATPase activity
B7L65_19475	COG2175	clavaminate synthase activity
B7L65_19485	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B7L65_19490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L65_19510	COG4771	TonB-dependent receptor
B7L65_19520	COG0667	Aldo Keto reductase
B7L65_19530	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B7L65_19535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B7L65_19545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B7L65_19550	COG4106	trans-aconitate 2-methyltransferase activity
B7L65_19560	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B7L65_19605	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B7L65_19620	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B7L65_19625	COG2226	methyltransferase
B7L65_19660	COG0366	Alpha amylase catalytic
B7L65_19690	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_19690	COG3321	synthase
B7L65_19690	COG0604	alcohol dehydrogenase
B7L65_19705	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B7L65_19715	COG0494	nUDIX hydrolase
B7L65_19720	COG0653	protein targeting
B7L65_19725	COG0739	heme binding
B7L65_19735	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B7L65_19750	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B7L65_19755	COG1181	Belongs to the D-alanine--D-alanine ligase family
B7L65_19760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B7L65_19765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B7L65_19775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B7L65_19780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B7L65_19785	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B7L65_19795	COG3116	cell division
B7L65_19800	COG0275	rRNA processing
B7L65_19805	COG2001	Belongs to the MraZ family
B7L65_19835	COG0792	nuclease activity
B7L65_19840	COG1988	membrane-bound metal-dependent
B7L65_19845	COG0277	FAD linked oxidase domain protein
B7L65_19860	COG0745	RESPONSE REGULATOR receiver
B7L65_19865	COG2205	protein histidine kinase activity
B7L65_19870	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B7L65_19875	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B7L65_19880	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B7L65_19905	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B7L65_19910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B7L65_19915	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B7L65_19935	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B7L65_19935	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B7L65_19945	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B7L65_19950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B7L65_19960	COG0488	(ABC) transporter
B7L65_19970	COG0697	spore germination
B7L65_19980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B7L65_19995	COG3791	Glutathione-dependent formaldehyde-activating
B7L65_20020	COG0745	RESPONSE REGULATOR receiver
B7L65_20025	COG2205	protein histidine kinase activity
B7L65_20045	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B7L65_20050	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B7L65_20065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B7L65_20080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B7L65_20085	COG1012	belongs to the aldehyde dehydrogenase family
B7L65_20090	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B7L65_20095	COG0617	tRNA 3'-terminal CCA addition
B7L65_20105	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B7L65_20110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B7L65_20115	COG1609	Transcriptional regulator
B7L65_20140	COG3250	beta-galactosidase activity
B7L65_20190	COG1459	type II secretion system
B7L65_20250	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B7L65_20255	COG4191	Histidine kinase
B7L65_20260	COG0784	Response regulator, receiver
B7L65_20265	COG4251	negative regulation of phosphorylation
B7L65_20270	COG2823	Periplasmic or secreted lipoprotein
B7L65_20275	COG0673	inositol 2-dehydrogenase activity
B7L65_20280	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B7L65_20315	COG1056	cytidyltransferase-related domain
B7L65_20315	COG1051	belongs to the nudix hydrolase family
B7L65_20325	COG0583	DNA-binding transcription factor activity
B7L65_20340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B7L65_20345	COG0321	lipoyl(octanoyl) transferase activity
B7L65_20350	COG2921	Belongs to the UPF0250 family
B7L65_20360	COG1686	Belongs to the peptidase S11 family
B7L65_20370	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B7L65_20375	COG2951	lytic endotransglycosylase activity
B7L65_20385	COG0772	Belongs to the SEDS family
B7L65_20400	COG1792	Involved in formation and maintenance of cell shape
B7L65_20405	COG1077	Cell shape determining protein MreB Mrl
B7L65_20415	COG3284	Transcriptional regulator
B7L65_20465	COG0308	aminopeptidase N
B7L65_20470	COG5001	Diguanylate cyclase
B7L65_20470	COG3300	MHYT domain
B7L65_20475	COG2226	methyltransferase
B7L65_20500	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B7L65_20505	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B7L65_20510	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B7L65_20520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B7L65_20530	COG2832	Protein of unknown function (DUF454)
B7L65_20545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B7L65_20550	COG1505	serine-type exopeptidase activity
B7L65_20580	COG0181	hydroxymethylbilane synthase activity
B7L65_20590	COG3275	phosphorelay sensor kinase activity
B7L65_20600	COG2943	transferase activity, transferring hexosyl groups
B7L65_20620	COG3706	GGDEF domain
B7L65_20635	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L65_20635	COG5297	Belongs to the glycosyl hydrolase family 6
B7L65_20640	COG0840	transmembrane signaling receptor activity
B7L65_20645	COG5001	Diguanylate cyclase
B7L65_20700	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
B7L65_20710	COG0598	Magnesium transport protein CorA
B7L65_20720	COG1113	amino acid transport
B7L65_20735	COG0697	spore germination
B7L65_20775	COG1506	peptidase
B7L65_20775	COG0823	Involved in the tonB-independent uptake of proteins
B7L65_20785	COG2409	Drug exporters of the RND superfamily
B7L65_20955	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B7L65_20975	COG3012	SEC-C Motif Domain Protein
B7L65_20975	COG3318	Belongs to the UPF0149 family
B7L65_21010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B7L65_21015	COG4456	Virulence-associated protein
B7L65_21050	COG4191	Histidine kinase
B7L65_21050	COG0784	Response regulator, receiver
B7L65_21185	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B7L65_21215	COG2022	thiamine diphosphate biosynthetic process
B7L65_21225	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B7L65_21230	COG0471	metal ion transport
B7L65_21230	COG3273	potassium ion transport
B7L65_21255	COG1970	mechanosensitive ion channel activity
B7L65_21275	COG3250	beta-galactosidase activity
B7L65_21280	COG4948	Mandelate Racemase Muconate Lactonizing
B7L65_21295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B7L65_21305	COG0308	aminopeptidase N
B7L65_21340	COG0435	Glutathione S-transferase
B7L65_21350	COG4221	oxidoreductase activity
B7L65_21365	COG4221	oxidoreductase activity
B7L65_21420	COG1802	Transcriptional regulator
B7L65_21430	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B7L65_21435	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
B7L65_21455	COG3052	prosthetic group binding
B7L65_21485	COG2353	YceI-like domain
B7L65_21490	COG0778	Nitroreductase
B7L65_21510	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B7L65_21515	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B7L65_21525	COG3386	PFAM SMP-30 Gluconolaconase
B7L65_21540	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B7L65_21555	COG0459	protein refolding
B7L65_21560	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B7L65_21570	COG2356	endonuclease I
B7L65_21575	COG0300	oxidoreductase activity
B7L65_21605	COG1324	tolerance protein
B7L65_21615	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B7L65_21620	COG0511	ligase activity, forming carbon-carbon bonds
B7L65_21630	COG0439	Biotin carboxylase
B7L65_21660	COG2264	protein methyltransferase activity
B7L65_21680	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
B7L65_21685	COG4589	Belongs to the CDS family
B7L65_21710	COG2453	phosphatase
B7L65_21710	COG0671	phosphoesterase, PA-phosphatase related
B7L65_21715	COG2267	carboxylic ester hydrolase activity
B7L65_21720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B7L65_21725	COG0138	bifunctional purine biosynthesis protein purh
B7L65_21735	COG0151	Belongs to the GarS family
B7L65_21745	COG1289	transmembrane transporter activity
B7L65_21750	COG2814	Major facilitator Superfamily
B7L65_21755	COG0583	DNA-binding transcription factor activity
B7L65_21760	COG2814	Major facilitator Superfamily
B7L65_21780	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B7L65_21800	COG0316	Belongs to the HesB IscA family
B7L65_21840	COG1051	belongs to the nudix hydrolase family
B7L65_21855	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B7L65_21860	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B7L65_21865	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
B7L65_21875	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B7L65_21880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B7L65_21890	COG0134	indole-3-glycerol-phosphate synthase activity
B7L65_21895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B7L65_21920	COG1597	lipid kinase activity
B7L65_21940	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B7L65_21945	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B7L65_21965	COG3179	chitinase
B7L65_21985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B7L65_21985	COG2111	Na H antiporter
B7L65_21990	COG1006	Multisubunit Na H antiporter MnhC subunit
B7L65_21995	COG0651	ATP synthesis coupled electron transport
B7L65_22005	COG2212	antiporter activity
B7L65_22010	COG1320	monovalent cation:proton antiporter activity
B7L65_22030	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B7L65_22055	COG3104	oligopeptide transport
B7L65_22060	COG3483	tryptophan 2,3-dioxygenase activity
B7L65_22070	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B7L65_22090	COG0513	Belongs to the DEAD box helicase family
B7L65_22100	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_22105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L65_22140	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_22145	COG0702	epimerase
B7L65_22170	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B7L65_22175	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B7L65_22180	COG0297	glycogen (starch) synthase activity
B7L65_22185	COG3706	GGDEF domain
B7L65_22185	COG0745	RESPONSE REGULATOR receiver
B7L65_22190	COG2354	Protein conserved in bacteria
B7L65_22205	COG1368	sulfuric ester hydrolase activity
B7L65_22210	COG3264	Mechanosensitive ion channel
B7L65_22210	COG1511	domain protein
B7L65_22280	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B7L65_22370	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B7L65_22375	COG1040	competence protein
B7L65_22380	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B7L65_22385	COG0156	8-amino-7-oxononanoate synthase activity
B7L65_22395	COG2267	carboxylic ester hydrolase activity
B7L65_22435	COG0445	tRNA wobble uridine modification
B7L65_22455	COG1414	Transcriptional regulator
B7L65_22465	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B7L65_22470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B7L65_22480	COG3485	protocatechuate 3,4-dioxygenase
B7L65_22485	COG3485	protocatechuate 3,4-dioxygenase
B7L65_22495	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B7L65_22500	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B7L65_22525	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B7L65_22530	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B7L65_22585	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B7L65_22600	COG0129	dihydroxy-acid dehydratase activity
B7L65_22645	COG1733	regulation of RNA biosynthetic process
B7L65_22650	COG0702	epimerase
B7L65_22685	COG0583	DNA-binding transcription factor activity
B7L65_22690	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B7L65_22695	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B7L65_22705	COG1538	Outer membrane efflux protein
B7L65_22715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L65_22720	COG2205	protein histidine kinase activity
B7L65_22725	COG0745	RESPONSE REGULATOR receiver
B7L65_22745	COG1902	pentaerythritol trinitrate reductase activity
B7L65_22750	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B7L65_22755	COG2267	carboxylic ester hydrolase activity
B7L65_22765	COG2814	Major facilitator Superfamily
B7L65_22770	COG0583	DNA-binding transcription factor activity
B7L65_22785	COG0084	hydrolase, TatD family'
B7L65_22810	COG2252	PERMEase
B7L65_22820	COG1957	nucleoside hydrolase
B7L65_22855	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B7L65_22875	COG2072	flavoprotein involved in K transport
B7L65_22880	COG2351	hydroxyisourate hydrolase activity
B7L65_22885	COG4807	Protein conserved in bacteria
B7L65_22895	COG1643	Atp-dependent helicase
B7L65_22910	COG1187	pseudouridine synthase activity
B7L65_22925	COG2130	NADP-dependent
B7L65_22955	COG1764	response to oxidative stress
B7L65_22960	COG1846	Transcriptional regulator
B7L65_22965	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B7L65_22975	COG0697	spore germination
B7L65_22985	COG0523	cobalamin synthesis protein
B7L65_23045	COG1960	acyl-CoA dehydrogenase activity
B7L65_23050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B7L65_23080	COG3706	GGDEF domain
B7L65_23090	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B7L65_23095	COG0583	DNA-binding transcription factor activity
B7L65_23100	COG0475	glutathione-regulated potassium exporter activity
B7L65_23130	COG0339	signal peptide processing
B7L65_23155	COG0564	pseudouridine synthase activity
B7L65_23165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B7L65_23180	COG1181	Belongs to the D-alanine--D-alanine ligase family
B7L65_23195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B7L65_23200	COG0318	PFAM AMP-dependent synthetase and ligase
B7L65_23210	COG0596	Alpha beta hydrolase
B7L65_23235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B7L65_23250	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B7L65_23275	COG2205	protein histidine kinase activity
B7L65_23280	COG0028	Belongs to the TPP enzyme family
B7L65_23295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B7L65_23300	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B7L65_23305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B7L65_23340	COG0183	Belongs to the thiolase family
B7L65_23360	COG2032	superoxide dismutase activity
B7L65_23365	COG2032	superoxide dismutase activity
B7L65_23380	COG2204	response regulator
B7L65_23385	COG3852	Histidine kinase
B7L65_23390	COG0004	ammonium transporteR
B7L65_23395	COG0347	Belongs to the P(II) protein family
B7L65_23400	COG0174	glutamine synthetase
B7L65_23405	COG1968	undecaprenyl-diphosphatase activity
B7L65_23455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L65_23465	COG2062	phosphohistidine phosphatase, SixA
B7L65_23470	COG0489	protein tyrosine kinase activity
B7L65_23495	COG1396	sequence-specific DNA binding
B7L65_23515	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B7L65_23530	COG1125	glycine betaine transport
B7L65_23545	COG1119	ATPase activity
B7L65_23555	COG1752	Esterase of the alpha-beta hydrolase superfamily
B7L65_23565	COG1522	sequence-specific DNA binding
B7L65_23570	COG3186	Phenylalanine-4-hydroxylase
B7L65_23585	COG2755	lipolytic protein G-D-S-L family
B7L65_23595	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_23600	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
B7L65_23610	COG1609	Transcriptional regulator
B7L65_23615	COG3507	Belongs to the glycosyl hydrolase 43 family
B7L65_23630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B7L65_23640	COG0657	acetylesterase activity
B7L65_23640	COG2755	lipolytic protein G-D-S-L family
B7L65_23660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B7L65_23665	COG0366	Alpha amylase catalytic
B7L65_23670	COG0366	Alpha amylase catalytic
B7L65_23760	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B7L65_23765	COG3710	Transcriptional regulator
B7L65_23785	COG2197	response regulator
B7L65_23790	COG4585	Histidine kinase
B7L65_23805	COG1304	FMN binding
B7L65_23830	COG1012	belongs to the aldehyde dehydrogenase family
B7L65_23835	COG0662	Cupin 2, conserved barrel domain protein
B7L65_23845	COG4772	TonB-dependent receptor
B7L65_23855	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B7L65_23885	COG0714	Associated with various cellular activities
B7L65_23925	COG0477	Major facilitator Superfamily
B7L65_23935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B7L65_23985	COG3237	CsbD-like
B7L65_24050	COG2249	NAD(P)H dehydrogenase (quinone) activity
B7L65_24075	COG1028	Short-chain dehydrogenase reductase Sdr
B7L65_24080	COG0300	oxidoreductase activity
B7L65_24100	COG1272	protein, Hemolysin III
B7L65_24105	COG1111	helicase
B7L65_24105	COG1205	dead DEAH box helicase
B7L65_24230	COG1132	(ABC) transporter
B7L65_24255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L65_24265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L65_24265	COG0551	DNA topoisomerase type I activity
B7L65_24280	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B7L65_24345	COG0305	Participates in initiation and elongation during chromosome replication
B7L65_24450	COG4974	Belongs to the 'phage' integrase family
B7L65_24860	COG1674	ftsk spoiiie
B7L65_25015	COG0489	protein tyrosine kinase activity
B7L65_25120	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B7L65_25140	COG3012	SEC-C Motif Domain Protein
B7L65_25140	COG3318	Belongs to the UPF0149 family
B7L65_25160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L65_25195	COG3846	protein secretion by the type IV secretion system
B7L65_25205	COG3451	type IV secretory pathway VirB4
B7L65_25215	COG3838	Conjugal transfer protein Trbc
B7L65_25220	COG4962	Type ii secretion system protein e