locus-tag	class	description
B7L66_00005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B7L66_00020	COG0583	DNA-binding transcription factor activity
B7L66_00030	COG1056	cytidyltransferase-related domain
B7L66_00030	COG1051	belongs to the nudix hydrolase family
B7L66_00065	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B7L66_00070	COG0673	inositol 2-dehydrogenase activity
B7L66_00075	COG2823	Periplasmic or secreted lipoprotein
B7L66_00080	COG4251	negative regulation of phosphorylation
B7L66_00085	COG0784	Response regulator, receiver
B7L66_00090	COG4191	Histidine kinase
B7L66_00095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B7L66_00155	COG1459	type II secretion system
B7L66_00205	COG3250	beta-galactosidase activity
B7L66_00230	COG1609	Transcriptional regulator
B7L66_00235	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B7L66_00240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B7L66_00250	COG0617	tRNA 3'-terminal CCA addition
B7L66_00255	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B7L66_00260	COG1012	belongs to the aldehyde dehydrogenase family
B7L66_00265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B7L66_00280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B7L66_00295	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B7L66_00300	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B7L66_00320	COG2205	protein histidine kinase activity
B7L66_00325	COG0745	RESPONSE REGULATOR receiver
B7L66_00350	COG3791	Glutathione-dependent formaldehyde-activating
B7L66_00365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B7L66_00375	COG0697	spore germination
B7L66_00385	COG0488	(ABC) transporter
B7L66_00395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B7L66_00400	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B7L66_00410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B7L66_00410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B7L66_00430	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B7L66_00435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B7L66_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B7L66_00465	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B7L66_00470	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B7L66_00475	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B7L66_00480	COG2205	protein histidine kinase activity
B7L66_00485	COG0745	RESPONSE REGULATOR receiver
B7L66_00510	COG0277	FAD linked oxidase domain protein
B7L66_00515	COG1988	membrane-bound metal-dependent
B7L66_00520	COG0792	nuclease activity
B7L66_00550	COG2001	Belongs to the MraZ family
B7L66_00555	COG0275	rRNA processing
B7L66_00560	COG3116	cell division
B7L66_00570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B7L66_00575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B7L66_00580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B7L66_00590	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B7L66_00595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B7L66_00600	COG1181	Belongs to the D-alanine--D-alanine ligase family
B7L66_00605	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B7L66_00620	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B7L66_00630	COG0739	heme binding
B7L66_00635	COG0653	protein targeting
B7L66_00640	COG0494	nUDIX hydrolase
B7L66_00650	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B7L66_00665	COG0604	alcohol dehydrogenase
B7L66_00665	COG3321	synthase
B7L66_00665	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_00695	COG0366	Alpha amylase catalytic
B7L66_00730	COG2226	methyltransferase
B7L66_00735	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B7L66_00750	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B7L66_00795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B7L66_00805	COG4106	trans-aconitate 2-methyltransferase activity
B7L66_00810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B7L66_00820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B7L66_00825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B7L66_00835	COG0667	Aldo Keto reductase
B7L66_00845	COG4771	TonB-dependent receptor
B7L66_00865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L66_00870	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B7L66_00880	COG2175	clavaminate synthase activity
B7L66_00885	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B7L66_00890	COG4181	ATPase activity
B7L66_00905	COG0642	Histidine kinase
B7L66_00920	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B7L66_00940	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B7L66_00945	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B7L66_00960	COG3829	transcription factor binding
B7L66_00970	COG1116	anion transmembrane transporter activity
B7L66_00975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L66_00985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B7L66_00990	COG0431	NADPH-dependent FMN reductase
B7L66_01015	COG0747	negative chemotaxis
B7L66_01035	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B7L66_01040	COG2967	ApaG domain
B7L66_01045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B7L66_01050	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B7L66_01055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B7L66_01060	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B7L66_01075	COG0123	including yeast histone deacetylase and acetoin utilization protein
B7L66_01080	COG2096	Adenosyltransferase
B7L66_01095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L66_01100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L66_01130	COG3384	dioxygenase
B7L66_01135	COG0583	DNA-binding transcription factor activity
B7L66_01150	COG1024	Enoyl-CoA hydratase
B7L66_01170	COG3386	PFAM SMP-30 Gluconolaconase
B7L66_01185	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
B7L66_01210	COG0697	spore germination
B7L66_01220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L66_01235	COG0745	RESPONSE REGULATOR receiver
B7L66_01235	COG3706	GGDEF domain
B7L66_01240	COG5002	protein histidine kinase activity
B7L66_01240	COG2205	protein histidine kinase activity
B7L66_01240	COG0784	Response regulator, receiver
B7L66_01245	COG2197	response regulator
B7L66_01255	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B7L66_01265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B7L66_01270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B7L66_01280	COG0583	DNA-binding transcription factor activity
B7L66_01285	COG3634	alkyl hydroperoxide reductase activity
B7L66_01295	COG2890	protein-(glutamine-N5) methyltransferase activity
B7L66_01315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B7L66_01315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B7L66_01345	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B7L66_01365	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B7L66_01370	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B7L66_01385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B7L66_01390	COG1404	Belongs to the peptidase S8 family
B7L66_01395	COG1404	Belongs to the peptidase S8 family
B7L66_01400	COG1404	Belongs to the peptidase S8 family
B7L66_01405	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B7L66_01430	COG1295	ribonuclease BN
B7L66_01435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B7L66_01455	COG0521	Mo-molybdopterin cofactor biosynthetic process
B7L66_01465	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B7L66_01480	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B7L66_01485	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B7L66_01495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B7L66_01500	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B7L66_01505	COG0193	aminoacyl-tRNA hydrolase activity
B7L66_01510	COG0012	GTP binding
B7L66_01530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B7L66_01540	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B7L66_01545	COG0250	Participates in transcription elongation, termination and antitermination
B7L66_01550	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B7L66_01555	COG0081	regulation of translation
B7L66_01560	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B7L66_01565	COG0222	ribosome binding
B7L66_01570	COG0085	RNA polymerase activity
B7L66_01575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B7L66_01580	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B7L66_01585	COG0049	tRNA binding
B7L66_01590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B7L66_01595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B7L66_01600	COG0051	transcription antitermination factor activity, RNA binding
B7L66_01605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B7L66_01610	COG0088	Forms part of the polypeptide exit tunnel
B7L66_01615	COG0089	rRNA binding
B7L66_01620	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B7L66_01625	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B7L66_01630	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B7L66_01635	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B7L66_01640	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B7L66_01645	COG0255	Belongs to the universal ribosomal protein uL29 family
B7L66_01650	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B7L66_01655	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B7L66_01660	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B7L66_01665	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B7L66_01670	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B7L66_01675	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B7L66_01680	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B7L66_01685	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B7L66_01690	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B7L66_01695	COG1841	ribosomal large subunit assembly
B7L66_01700	COG0200	Binds to the 23S rRNA
B7L66_01705	COG0201	protein transport
B7L66_01710	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B7L66_01715	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B7L66_01720	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B7L66_01725	COG0202	RNA polymerase activity
B7L66_01730	COG0203	ribosomal protein L17
B7L66_01735	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B7L66_01755	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B7L66_01765	COG0154	amidase activity
B7L66_01780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B7L66_01785	COG0039	L-malate dehydrogenase activity
B7L66_01790	COG0625	glutathione transferase activity
B7L66_01810	COG0446	pyridine nucleotide-disulphide oxidoreductase
B7L66_01810	COG1902	pentaerythritol trinitrate reductase activity
B7L66_01815	COG0604	alcohol dehydrogenase
B7L66_01845	COG0156	8-amino-7-oxononanoate synthase activity
B7L66_01850	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
B7L66_01855	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
B7L66_01860	COG4208	sulfate ABC transporter
B7L66_01865	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B7L66_01875	COG1063	alcohol dehydrogenase
B7L66_01910	COG0285	dihydrofolate synthase activity
B7L66_01930	COG2833	Protein of unknown function (DUF455)
B7L66_01940	COG3291	Pkd domain containing protein
B7L66_01950	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L66_01955	COG0671	phosphoesterase, PA-phosphatase related
B7L66_01960	COG0438	transferase activity, transferring glycosyl groups
B7L66_01970	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B7L66_01985	COG4783	chaperone-mediated protein folding
B7L66_02000	COG0473	3-isopropylmalate dehydrogenase activity
B7L66_02155	COG0544	peptidyl-prolyl cis-trans isomerase activity
B7L66_02160	COG0740	serine-type endopeptidase activity
B7L66_02165	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B7L66_02195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B7L66_02205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L66_02215	COG0328	RNA-DNA hybrid ribonuclease activity
B7L66_02220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B7L66_02225	COG0631	protein serine/threonine phosphatase activity
B7L66_02240	COG0859	PFAM glycosyl transferase family 9
B7L66_02245	COG3642	lipopolysaccharide core region biosynthetic process
B7L66_02250	COG1234	tRNA 3'-trailer cleavage
B7L66_02255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B7L66_02265	COG0315	cyclic pyranopterin monophosphate synthase activity
B7L66_02270	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B7L66_02275	COG0314	molybdopterin synthase activity
B7L66_02325	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B7L66_02330	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B7L66_02335	COG0537	adenosine 5'-monophosphoramidase activity
B7L66_02355	COG0714	Associated with various cellular activities
B7L66_02375	COG0424	maF-like protein
B7L66_02380	COG1399	metal-binding, possibly nucleic acid-binding protein
B7L66_02385	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B7L66_02390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B7L66_02405	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_02410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B7L66_02420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B7L66_02425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B7L66_02450	COG3829	transcription factor binding
B7L66_02470	COG3609	addiction module antidote protein, CC2985 family
B7L66_02500	COG2373	Large extracellular alpha-helical protein
B7L66_02520	COG4953	penicillin-binding protein 1C
B7L66_02530	COG0678	peroxiredoxin activity
B7L66_02555	COG0330	HflC and HflK could
B7L66_02560	COG0330	HflC and HflK could
B7L66_02570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B7L66_02575	COG0308	aminopeptidase N
B7L66_02580	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_02585	COG1309	transcriptional regulator
B7L66_02630	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B7L66_02660	COG0328	RNA-DNA hybrid ribonuclease activity
B7L66_02660	COG0406	alpha-ribazole phosphatase activity
B7L66_02665	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B7L66_02675	COG3387	PFAM Glycoside hydrolase 15-related
B7L66_02680	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_02720	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B7L66_02725	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B7L66_02730	COG2080	2 iron, 2 sulfur cluster binding
B7L66_02765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B7L66_02780	COG0587	DNA-directed DNA polymerase activity
B7L66_02800	COG1297	OPT oligopeptide transporter protein
B7L66_02815	COG1506	peptidase
B7L66_02815	COG0823	Involved in the tonB-independent uptake of proteins
B7L66_02830	COG2207	Transcriptional regulator
B7L66_02830	COG1917	Cupin 2, conserved barrel domain protein
B7L66_02845	COG0753	catalase activity
B7L66_02850	COG0656	L-ascorbic acid biosynthetic process
B7L66_02860	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B7L66_02860	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B7L66_02865	COG2814	Major facilitator Superfamily
B7L66_02880	COG2194	sulfuric ester hydrolase activity
B7L66_02895	COG0745	RESPONSE REGULATOR receiver
B7L66_02900	COG0642	Histidine kinase
B7L66_02910	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B7L66_02915	COG2894	cell division
B7L66_02920	COG0850	regulation of cytokinetic process
B7L66_02935	COG4585	Histidine kinase
B7L66_02940	COG2197	response regulator
B7L66_02955	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B7L66_02985	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B7L66_02995	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B7L66_03015	COG1946	Acyl-CoA thioesterase
B7L66_03030	COG0824	Thioesterase
B7L66_03035	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B7L66_03040	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B7L66_03045	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B7L66_03050	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B7L66_03055	COG0268	Binds directly to 16S ribosomal RNA
B7L66_03065	COG0196	riboflavin kinase activity
B7L66_03070	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B7L66_03075	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B7L66_03080	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B7L66_03095	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B7L66_03100	COG1845	cytochrome c oxidase, subunit III
B7L66_03105	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B7L66_03125	COG3152	Membrane
B7L66_03135	COG2207	Transcriptional regulator
B7L66_03140	COG0326	Molecular chaperone. Has ATPase activity
B7L66_03155	COG1366	Belongs to the anti-sigma-factor antagonist family
B7L66_03160	COG1366	Belongs to the anti-sigma-factor antagonist family
B7L66_03165	COG2172	sigma factor antagonist activity
B7L66_03190	COG4771	TonB-dependent receptor
B7L66_03200	COG5507	3-demethylubiquinone-9 3-methyltransferase
B7L66_03205	COG2205	protein histidine kinase activity
B7L66_03215	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B7L66_03220	COG4999	Histidine kinase
B7L66_03220	COG3850	Histidine kinase
B7L66_03220	COG2205	protein histidine kinase activity
B7L66_03220	COG3437	response regulator, receiver
B7L66_03225	COG4191	Histidine kinase
B7L66_03225	COG0784	Response regulator, receiver
B7L66_03250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B7L66_03260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B7L66_03270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B7L66_03275	COG0228	four-way junction DNA binding
B7L66_03280	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B7L66_03285	COG0336	Belongs to the RNA methyltransferase TrmD family
B7L66_03290	COG0335	large ribosomal subunit rRNA binding
B7L66_03295	COG0534	Mate efflux family protein
B7L66_03315	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B7L66_03325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B7L66_03335	COG3209	COG3209 Rhs family protein
B7L66_03360	COG3250	beta-galactosidase activity
B7L66_03365	COG3867	Arabinogalactan endo-beta-1,4-galactanase
B7L66_03385	COG1960	acyl-CoA dehydrogenase activity
B7L66_03390	COG1024	Enoyl-CoA hydratase
B7L66_03410	COG1024	Enoyl-CoA hydratase
B7L66_03410	COG1250	3-hydroxyacyl-CoA dehydrogenase
B7L66_03425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B7L66_03430	COG0481	GTPase activity
B7L66_03445	COG0571	ribonuclease III activity
B7L66_03450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B7L66_03455	COG1381	Involved in DNA repair and RecF pathway recombination
B7L66_03465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B7L66_03475	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B7L66_03480	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
B7L66_03485	COG3046	protein related to deoxyribodipyrimidine photolyase
B7L66_03490	COG1472	Belongs to the glycosyl hydrolase 3 family
B7L66_03500	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B7L66_03505	COG1278	Cold shock
B7L66_03510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L66_03520	COG1201	RNA secondary structure unwinding
B7L66_03525	COG1793	dna ligase
B7L66_03535	COG1793	dna ligase
B7L66_03535	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B7L66_03550	COG3706	GGDEF domain
B7L66_03550	COG0745	RESPONSE REGULATOR receiver
B7L66_03570	COG0183	Belongs to the thiolase family
B7L66_03595	COG1451	nucleotide metabolic process
B7L66_03600	COG5487	UPF0391 membrane protein
B7L66_03610	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B7L66_03625	COG1077	Cell shape determining protein MreB Mrl
B7L66_03630	COG1047	Peptidyl-prolyl cis-trans
B7L66_03640	COG2824	Alkylphosphonate utilization operon protein PhnA
B7L66_03650	COG1902	pentaerythritol trinitrate reductase activity
B7L66_03655	COG2814	Major facilitator Superfamily
B7L66_03685	COG0392	lysyltransferase activity
B7L66_03685	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B7L66_03695	COG0251	oxidation-reduction process
B7L66_03700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B7L66_03715	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B7L66_03740	COG1595	DNA-templated transcription, initiation
B7L66_03760	COG2878	Part of a membrane complex involved in electron transport
B7L66_03770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L66_03770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L66_03785	COG1131	(ABC) transporter
B7L66_03790	COG0346	lactoylglutathione lyase activity
B7L66_03795	COG0833	amino acid
B7L66_03800	COG2040	homocysteine
B7L66_03810	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B7L66_03830	COG1695	Transcriptional regulator
B7L66_03865	COG0825	malonyl-CoA metabolic process
B7L66_03875	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B7L66_03880	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L66_03885	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L66_03890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B7L66_03895	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L66_03910	COG0750	zinc metalloprotease
B7L66_03915	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B7L66_03920	COG0575	Belongs to the CDS family
B7L66_03925	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B7L66_03930	COG0233	cytoplasmic translational termination
B7L66_03935	COG0528	UMP kinase activity
B7L66_03940	COG0745	RESPONSE REGULATOR receiver
B7L66_03940	COG3706	GGDEF domain
B7L66_03945	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B7L66_03950	COG0052	Belongs to the universal ribosomal protein uS2 family
B7L66_03985	COG0024	Methionine aminopeptidase
B7L66_03990	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B7L66_04000	COG1393	Belongs to the ArsC family
B7L66_04005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B7L66_04010	COG0367	asparagine synthase
B7L66_04020	COG4774	siderophore transport
B7L66_04040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B7L66_04070	COG1566	PFAM secretion protein HlyD family protein
B7L66_04075	COG2814	Major facilitator Superfamily
B7L66_04095	COG3104	oligopeptide transport
B7L66_04125	COG0339	signal peptide processing
B7L66_04135	COG0386	Belongs to the glutathione peroxidase family
B7L66_04190	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B7L66_04195	COG0084	hydrolase, TatD family'
B7L66_04210	COG1960	acyl-CoA dehydrogenase activity
B7L66_04230	COG0367	asparagine synthase
B7L66_04240	COG0305	Participates in initiation and elongation during chromosome replication
B7L66_04245	COG0415	Belongs to the DNA photolyase family
B7L66_04265	COG0583	DNA-binding transcription factor activity
B7L66_04300	COG3706	GGDEF domain
B7L66_04310	COG3706	GGDEF domain
B7L66_04360	COG0237	dephospho-CoA kinase activity
B7L66_04365	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B7L66_04400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B7L66_04415	COG0045	succinate-CoA ligase (ADP-forming) activity
B7L66_04420	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B7L66_04445	COG2369	cell adhesion
B7L66_04465	COG4644	lycopene metabolic process
B7L66_04470	COG2951	lytic endotransglycosylase activity
B7L66_04495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B7L66_04495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B7L66_04505	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B7L66_04510	COG0564	pseudouridine synthase activity
B7L66_04525	COG3011	Protein conserved in bacteria
B7L66_04530	COG0840	transmembrane signaling receptor activity
B7L66_04550	COG3387	PFAM Glycoside hydrolase 15-related
B7L66_04555	COG1877	trehalose-phosphatase activity
B7L66_04595	COG2827	Endonuclease containing a URI domain
B7L66_04600	COG4771	TonB-dependent receptor
B7L66_04610	COG0667	Aldo Keto reductase
B7L66_04615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B7L66_04620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L66_04625	COG1116	anion transmembrane transporter activity
B7L66_04630	COG0542	response to heat
B7L66_04635	COG4206	TonB-dependent receptor
B7L66_04655	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B7L66_04665	COG1492	cobalamin metabolic process
B7L66_04675	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B7L66_04710	COG0019	diaminopimelate decarboxylase activity
B7L66_04725	COG4264	IucA IucC family
B7L66_04735	COG4772	TonB-dependent receptor
B7L66_04760	COG4651	solute:proton antiporter activity
B7L66_04760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B7L66_04800	COG0488	(ABC) transporter
B7L66_04845	COG0477	Major facilitator Superfamily
B7L66_04860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B7L66_04875	COG0217	transcriptional regulatory protein
B7L66_04880	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B7L66_04885	COG0632	four-way junction helicase activity
B7L66_04890	COG3158	transport of potassium into the cell
B7L66_04900	COG2255	four-way junction helicase activity
B7L66_04905	COG0824	Thioesterase
B7L66_04915	COG0848	biopolymer transport protein
B7L66_04925	COG0823	Involved in the tonB-independent uptake of proteins
B7L66_04930	COG2885	chlorophyll binding
B7L66_04940	COG0602	queuosine metabolic process
B7L66_04950	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B7L66_04955	COG3920	Histidine kinase
B7L66_04975	COG0840	transmembrane signaling receptor activity
B7L66_05005	COG0514	ATP-dependent DNA helicase (RecQ)
B7L66_05015	COG0783	Belongs to the Dps family
B7L66_05020	COG1643	Atp-dependent helicase
B7L66_05035	COG0837	glucose binding
B7L66_05055	COG0535	radical SAM domain protein
B7L66_05060	COG0535	radical SAM domain protein
B7L66_05065	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
B7L66_05070	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B7L66_05080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B7L66_05100	COG1215	transferase activity, transferring glycosyl groups
B7L66_05105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B7L66_05115	COG1199	ATP-dependent helicase activity
B7L66_05125	COG1397	ADP-ribosylglycohydrolase
B7L66_05135	COG0189	ligase activity
B7L66_05155	COG0840	transmembrane signaling receptor activity
B7L66_05195	COG1446	asparaginase
B7L66_05200	COG3142	Participates in the control of copper homeostasis
B7L66_05240	COG3537	Alpha-1,2-mannosidase
B7L66_05250	COG1486	melibiose metabolic process
B7L66_05260	COG0531	amino acid
B7L66_05275	COG1472	Belongs to the glycosyl hydrolase 3 family
B7L66_05285	COG3525	Glycosyl hydrolase, family 20, catalytic domain
B7L66_05290	COG1388	LysM domain
B7L66_05290	COG3858	chitin binding
B7L66_05305	COG0837	glucose binding
B7L66_05310	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B7L66_05320	COG0494	nUDIX hydrolase
B7L66_05330	COG3956	TIGRFAM MazG family protein
B7L66_05335	COG1742	UPF0060 membrane protein
B7L66_05340	COG0330	HflC and HflK could
B7L66_05350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B7L66_05355	COG0509	glycine decarboxylation via glycine cleavage system
B7L66_05380	COG1960	acyl-CoA dehydrogenase activity
B7L66_05385	COG2267	carboxylic ester hydrolase activity
B7L66_05390	COG1309	transcriptional regulator
B7L66_05400	COG4771	TonB-dependent receptor
B7L66_05410	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B7L66_05415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B7L66_05420	COG0463	Glycosyl transferase, family 2
B7L66_05425	COG0516	GMP reductase activity
B7L66_05425	COG0517	IMP dehydrogenase activity
B7L66_05435	COG1272	protein, Hemolysin III
B7L66_05440	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B7L66_05445	COG0739	heme binding
B7L66_05450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B7L66_05455	COG0626	cystathionine gamma-synthase activity
B7L66_05460	COG0460	homoserine dehydrogenase
B7L66_05460	COG0527	aspartate kinase activity
B7L66_05475	COG1760	l-serine dehydratase
B7L66_05495	COG2353	YceI-like domain
B7L66_05500	COG2205	protein histidine kinase activity
B7L66_05500	COG0784	Response regulator, receiver
B7L66_05500	COG2198	Histidine kinase
B7L66_05520	COG0477	Major facilitator Superfamily
B7L66_05595	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B7L66_05605	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B7L66_05610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B7L66_05615	COG0259	pyridoxamine-phosphate oxidase activity
B7L66_05625	COG1842	Phage shock protein A
B7L66_05650	COG0754	glutathionylspermidine amidase activity
B7L66_05660	COG2814	Major facilitator Superfamily
B7L66_05705	COG1234	tRNA 3'-trailer cleavage
B7L66_05740	COG0531	amino acid
B7L66_05745	COG2197	response regulator
B7L66_05775	COG1113	amino acid transport
B7L66_05785	COG1271	oxidase subunit
B7L66_05790	COG1294	oxidase, subunit
B7L66_05805	COG2239	Acts as a magnesium transporter
B7L66_05815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B7L66_05820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7L66_05830	COG1660	Displays ATPase and GTPase activities
B7L66_05835	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B7L66_05840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7L66_05855	COG1137	ATPase activity
B7L66_05860	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
B7L66_05870	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B7L66_05880	COG0271	Belongs to the BolA IbaG family
B7L66_05885	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B7L66_05905	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B7L66_05915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B7L66_05925	COG0628	permease
B7L66_05935	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B7L66_05940	COG3178	'Phosphotransferase
B7L66_05950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B7L66_05955	COG1555	photosystem II stabilization
B7L66_05970	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B7L66_05975	COG1477	protein flavinylation
B7L66_06000	COG3128	pkhd-type hydroxylase
B7L66_06005	COG4774	siderophore transport
B7L66_06020	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B7L66_06025	COG0719	Fe-S assembly protein
B7L66_06030	COG0396	ATPase activity
B7L66_06035	COG0719	Fe-S assembly protein
B7L66_06040	COG1959	2 iron, 2 sulfur cluster binding
B7L66_06050	COG0693	protein deglycase activity
B7L66_06070	COG0739	heme binding
B7L66_06085	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B7L66_06100	COG5297	Belongs to the glycosyl hydrolase family 6
B7L66_06110	COG0519	Catalyzes the synthesis of GMP from XMP
B7L66_06120	COG1678	Uncharacterized ACR, COG1678
B7L66_06125	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B7L66_06130	COG0540	Belongs to the ATCase OTCase family
B7L66_06135	COG1764	response to oxidative stress
B7L66_06145	COG0384	phenazine biosynthesis protein PhzF
B7L66_06150	COG0384	phenazine biosynthesis protein PhzF
B7L66_06155	COG0527	aspartate kinase activity
B7L66_06170	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B7L66_06185	COG0142	geranyltranstransferase activity
B7L66_06190	COG0629	single-stranded DNA binding
B7L66_06195	COG4251	negative regulation of phosphorylation
B7L66_06195	COG3706	GGDEF domain
B7L66_06195	COG2203	Gaf domain
B7L66_06195	COG5001	Diguanylate cyclase
B7L66_06210	COG2080	2 iron, 2 sulfur cluster binding
B7L66_06215	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B7L66_06220	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B7L66_06275	COG2879	small protein
B7L66_06280	COG1966	Carbon starvation protein
B7L66_06285	COG1741	Belongs to the pirin family
B7L66_06300	COG1741	Belongs to the pirin family
B7L66_06310	COG1515	deoxyribonuclease V activity
B7L66_06315	COG0588	phosphoglycerate mutase activity
B7L66_06325	COG3590	peptidase
B7L66_06330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L66_06335	COG2201	protein-glutamate methylesterase activity
B7L66_06340	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B7L66_06345	COG2202	Pas domain
B7L66_06345	COG2200	EAL domain
B7L66_06345	COG2199	diguanylate cyclase activity
B7L66_06350	COG0835	chemotaxis
B7L66_06355	COG0840	transmembrane signaling receptor activity
B7L66_06360	COG0643	Histidine kinase
B7L66_06360	COG2198	Histidine kinase
B7L66_06405	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B7L66_06415	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B7L66_06420	COG0745	RESPONSE REGULATOR receiver
B7L66_06425	COG2205	protein histidine kinase activity
B7L66_06435	COG4452	Inner membrane protein CreD
B7L66_06460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L66_06465	COG0735	belongs to the Fur family
B7L66_06480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L66_06485	COG1538	Outer membrane efflux protein
B7L66_06490	COG1309	transcriptional regulator
B7L66_06500	COG2207	Transcriptional regulator
B7L66_06510	COG0583	DNA-binding transcription factor activity
B7L66_06515	COG2814	Major facilitator Superfamily
B7L66_06520	COG0667	Aldo Keto reductase
B7L66_06590	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B7L66_06640	COG5001	Diguanylate cyclase
B7L66_06640	COG5002	protein histidine kinase activity
B7L66_06645	COG1187	pseudouridine synthase activity
B7L66_06650	COG3706	GGDEF domain
B7L66_06650	COG0745	RESPONSE REGULATOR receiver
B7L66_06670	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B7L66_06675	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B7L66_06680	COG0475	glutathione-regulated potassium exporter activity
B7L66_06685	COG5000	phosphorelay sensor kinase activity
B7L66_06685	COG5002	protein histidine kinase activity
B7L66_06690	COG0745	RESPONSE REGULATOR receiver
B7L66_06695	COG1538	Outer membrane efflux protein
B7L66_06725	COG1132	(ABC) transporter
B7L66_06765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B7L66_06770	COG2155	Conserved Protein
B7L66_06800	COG3118	belongs to the thioredoxin family
B7L66_06810	COG0495	leucyl-tRNA aminoacylation
B7L66_06825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B7L66_06840	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B7L66_06855	COG2968	Membrane
B7L66_06860	COG0424	maF-like protein
B7L66_06865	COG1530	ribonuclease E activity
B7L66_06870	COG3164	Protein of unknown function
B7L66_06880	COG0312	modulator of DNA gyrase
B7L66_06885	COG3028	Belongs to the UPF0307 family
B7L66_06890	COG0312	modulator of DNA gyrase
B7L66_06900	COG4104	PAAR repeat-containing protein
B7L66_06905	COG0142	geranyltranstransferase activity
B7L66_06910	COG1722	exodeoxyribonuclease VII activity
B7L66_06915	COG0037	tRNA processing
B7L66_06925	COG1785	Belongs to the alkaline phosphatase family
B7L66_06930	COG1301	dicarboxylic acid transport
B7L66_06935	COG4106	trans-aconitate 2-methyltransferase activity
B7L66_06945	COG0791	NLP P60 protein
B7L66_06950	COG0791	NLP P60 protein
B7L66_06955	COG1047	Peptidyl-prolyl cis-trans
B7L66_06960	COG2311	Membrane
B7L66_06965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L66_06970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B7L66_06990	COG3590	peptidase
B7L66_07000	COG3590	peptidase
B7L66_07020	COG0489	protein tyrosine kinase activity
B7L66_07030	COG0717	Belongs to the dCTP deaminase family
B7L66_07050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B7L66_07055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B7L66_07070	COG0494	nUDIX hydrolase
B7L66_07075	COG0433	COG0433 Predicted ATPase
B7L66_07090	COG0688	phosphatidylethanolamine metabolic process
B7L66_07100	COG2890	protein-(glutamine-N5) methyltransferase activity
B7L66_07105	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B7L66_07110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B7L66_07115	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B7L66_07140	COG0101	tRNA pseudouridine synthase activity
B7L66_07145	COG0135	phosphoribosylanthranilate isomerase activity
B7L66_07155	COG0133	tryptophan synthase activity
B7L66_07165	COG0159	tryptophan synthase activity
B7L66_07170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B7L66_07175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B7L66_07205	COG0300	oxidoreductase activity
B7L66_07210	COG0149	triose-phosphate isomerase activity
B7L66_07225	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B7L66_07230	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B7L66_07235	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B7L66_07240	COG0649	NAD binding
B7L66_07245	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
B7L66_07250	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B7L66_07260	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B7L66_07265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B7L66_07275	COG0713	ATP synthesis coupled electron transport
B7L66_07290	COG1007	ATP synthesis coupled electron transport
B7L66_07300	COG0779	Required for maturation of 30S ribosomal subunits
B7L66_07305	COG0195	Participates in both transcription termination and antitermination
B7L66_07310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B7L66_07315	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B7L66_07320	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B7L66_07325	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B7L66_07330	COG1185	polyribonucleotide nucleotidyltransferase activity
B7L66_07365	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B7L66_07370	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B7L66_07380	COG2095	MarC family integral membrane protein
B7L66_07395	COG1611	Belongs to the LOG family
B7L66_07400	COG3275	phosphorelay sensor kinase activity
B7L66_07440	COG2963	transposase activity
B7L66_07530	COG0556	nucleotide-excision repair
B7L66_07545	COG3505	Type IV secretory pathway VirD4
B7L66_07565	COG2948	multi-organism process
B7L66_07585	COG3702	type iv secretory pathway
B7L66_07675	COG0366	Alpha amylase catalytic
B7L66_07695	COG1082	Xylose isomerase domain protein TIM barrel
B7L66_07720	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B7L66_07725	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B7L66_07730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B7L66_07735	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B7L66_07740	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B7L66_07745	COG0072	phenylalanine-tRNA ligase activity
B7L66_07745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L66_07750	COG0776	regulation of translation
B7L66_07795	COG0438	transferase activity, transferring glycosyl groups
B7L66_07800	COG0438	transferase activity, transferring glycosyl groups
B7L66_07835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B7L66_07840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L66_07845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B7L66_07865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B7L66_07875	COG1960	acyl-CoA dehydrogenase activity
B7L66_07890	COG3040	lipid binding
B7L66_07905	COG0322	excinuclease ABC activity
B7L66_07920	COG0784	Response regulator, receiver
B7L66_07920	COG4191	Histidine kinase
B7L66_07925	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
B7L66_07930	COG1194	a g-specific adenine glycosylase
B7L66_07940	COG0552	protein localization to endoplasmic reticulum
B7L66_07950	COG3938	Belongs to the proline racemase family
B7L66_07955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L66_07970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B7L66_07980	COG0006	proline dipeptidase activity
B7L66_07995	COG0531	amino acid
B7L66_08100	COG0326	Molecular chaperone. Has ATPase activity
B7L66_08105	COG0742	ribosomal rna small subunit methyltransferase
B7L66_08110	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B7L66_08125	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B7L66_08130	COG0405	Gamma-glutamyltransferase
B7L66_08135	COG3291	Pkd domain containing protein
B7L66_08140	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B7L66_08185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B7L66_08190	COG0343	queuine tRNA-ribosyltransferase activity
B7L66_08195	COG1862	Preprotein translocase
B7L66_08205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B7L66_08245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B7L66_08245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B7L66_08250	COG1105	Belongs to the carbohydrate kinase PfkB family
B7L66_08255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7L66_08255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B7L66_08260	COG1609	Transcriptional regulator
B7L66_08265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L66_08270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L66_08280	COG2902	Dehydrogenase
B7L66_08290	COG0477	Major facilitator Superfamily
B7L66_08300	COG0784	Response regulator, receiver
B7L66_08300	COG5002	protein histidine kinase activity
B7L66_08300	COG2205	protein histidine kinase activity
B7L66_08305	COG2733	membrane
B7L66_08335	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B7L66_08340	COG0243	molybdopterin cofactor binding
B7L66_08350	COG0477	Major facilitator Superfamily
B7L66_08355	COG2703	oxygen carrier activity
B7L66_08360	COG3706	GGDEF domain
B7L66_08360	COG0745	RESPONSE REGULATOR receiver
B7L66_08365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L66_08370	COG0174	glutamine synthetase
B7L66_08375	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B7L66_08390	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B7L66_08410	COG3842	ATPase activity
B7L66_08415	COG1176	ABC-type spermidine putrescine transport system, permease component I
B7L66_08420	COG1177	transmembrane transport
B7L66_08425	COG1012	belongs to the aldehyde dehydrogenase family
B7L66_08440	COG4535	Mg2 and Co2 transporter CorC
B7L66_08450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B7L66_08460	COG1702	phosphate starvation-inducible protein PhoH
B7L66_08465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B7L66_08480	COG0741	lytic transglycosylase activity
B7L66_08490	COG0723	plastoquinol--plastocyanin reductase activity
B7L66_08495	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B7L66_08500	COG2857	Cytochrome c1
B7L66_08505	COG0625	glutathione transferase activity
B7L66_08510	COG2969	positive regulation of protein catabolic process
B7L66_08530	COG1201	RNA secondary structure unwinding
B7L66_08535	COG2094	Belongs to the DNA glycosylase MPG family
B7L66_08540	COG0840	transmembrane signaling receptor activity
B7L66_08545	COG0835	chemotaxis
B7L66_08735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B7L66_08745	COG1570	exodeoxyribonuclease VII activity
B7L66_08750	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B7L66_08755	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B7L66_08755	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B7L66_08760	COG0802	atpase or kinase
B7L66_08765	COG0860	N-Acetylmuramoyl-L-alanine amidase
B7L66_08770	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B7L66_08795	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_08800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L66_08805	COG0501	Belongs to the peptidase M48B family
B7L66_08815	COG2081	HI0933 family
B7L66_08820	COG4681	YaeQ
B7L66_08830	COG0625	glutathione transferase activity
B7L66_08845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B7L66_08850	COG0513	Belongs to the DEAD box helicase family
B7L66_08880	COG0483	inositol monophosphate 1-phosphatase activity
B7L66_08895	COG5001	Diguanylate cyclase
B7L66_08895	COG3300	MHYT domain
B7L66_08900	COG1509	lysine 2,3-aminomutase activity
B7L66_08905	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B7L66_08915	COG0402	S-adenosylhomocysteine deaminase activity
B7L66_08920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B7L66_08985	COG4302	ethanolamine ammonia-lyase activity
B7L66_09015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B7L66_09020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B7L66_09025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B7L66_09035	COG2166	iron-sulfur cluster assembly
B7L66_09040	COG0215	cysteine-tRNA ligase activity
B7L66_09050	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B7L66_09055	COG0137	argininosuccinate synthase activity
B7L66_09070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B7L66_09080	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B7L66_09085	COG0165	Argininosuccinate lyase
B7L66_09095	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B7L66_09100	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B7L66_09130	COG1294	oxidase, subunit
B7L66_09140	COG4988	ABC transporter
B7L66_09145	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B7L66_09150	COG1278	Cold shock
B7L66_09155	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B7L66_09175	COG1138	Cytochrome C-type biogenesis protein
B7L66_09180	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B7L66_09200	COG4133	protoheme IX ABC transporter activity
B7L66_09205	COG0436	Aminotransferase
B7L66_09225	COG1187	pseudouridine synthase activity
B7L66_09230	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B7L66_09235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B7L66_09240	COG2350	Protein conserved in bacteria
B7L66_09270	COG1175	transmembrane transport
B7L66_09275	COG0395	ABC-type sugar transport system, permease component
B7L66_09300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B7L66_09305	COG2957	Belongs to the agmatine deiminase family
B7L66_09320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B7L66_09325	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B7L66_09330	COG0539	negative regulation of cytoplasmic translation
B7L66_09335	COG0776	regulation of translation
B7L66_09345	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B7L66_09350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B7L66_09360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B7L66_09365	COG0475	glutathione-regulated potassium exporter activity
B7L66_09365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B7L66_09375	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B7L66_09385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B7L66_09385	COG0519	Catalyzes the synthesis of GMP from XMP
B7L66_09390	COG0582	viral genome integration into host DNA
B7L66_09425	COG2003	Belongs to the UPF0758 family
B7L66_09445	COG2084	Dehydrogenase
B7L66_09525	COG0210	DNA helicase
B7L66_09675	COG2207	Transcriptional regulator
B7L66_09680	COG2807	transmembrane transport
B7L66_09690	COG0655	NAD(P)H dehydrogenase (quinone) activity
B7L66_09695	COG3938	Belongs to the proline racemase family
B7L66_09705	COG2249	NAD(P)H dehydrogenase (quinone) activity
B7L66_09720	COG5006	permease, DMT superfamily
B7L66_09730	COG4804	nuclease activity
B7L66_09780	COG0270	DNA (cytosine-5-)-methyltransferase activity
B7L66_09825	COG1192	Involved in chromosome partitioning
B7L66_09835	COG2274	protein secretion by the type I secretion system
B7L66_09905	COG2336	PFAM SpoVT AbrB
B7L66_09930	COG4774	siderophore transport
B7L66_09940	COG0582	viral genome integration into host DNA
B7L66_09965	COG2003	Belongs to the UPF0758 family
B7L66_09970	COG5489	Protein of unknown function (DUF736)
B7L66_09975	COG1396	sequence-specific DNA binding
B7L66_09985	COG3002	Belongs to the UPF0753 family
B7L66_09990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B7L66_09995	COG0583	DNA-binding transcription factor activity
B7L66_10010	COG2197	response regulator
B7L66_10025	COG1335	isochorismatase
B7L66_10040	COG2814	Major facilitator Superfamily
B7L66_10055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B7L66_10055	COG1648	precorrin-2 dehydrogenase activity
B7L66_10080	COG3685	Protein conserved in bacteria
B7L66_10100	COG5001	Diguanylate cyclase
B7L66_10115	COG4566	intracellular signal transduction
B7L66_10165	COG3279	Response regulator of the LytR AlgR family
B7L66_10200	COG1238	metal cluster binding
B7L66_10335	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_10345	COG2226	methyltransferase
B7L66_10345	COG1073	alpha beta
B7L66_10390	COG0316	Belongs to the HesB IscA family
B7L66_10390	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B7L66_10395	COG2154	pterin-4-alpha-carbinolamine dehydratase
B7L66_10405	COG0428	transporter
B7L66_10410	COG3064	Membrane
B7L66_10420	COG1530	ribonuclease E activity
B7L66_10450	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B7L66_10460	COG0582	viral genome integration into host DNA
B7L66_10480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B7L66_10550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B7L66_10585	COG1192	Involved in chromosome partitioning
B7L66_10620	COG0629	single-stranded DNA binding
B7L66_10625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L66_10635	COG0270	DNA (cytosine-5-)-methyltransferase activity
B7L66_10815	COG2003	Belongs to the UPF0758 family
B7L66_10930	COG0583	DNA-binding transcription factor activity
B7L66_10945	COG1396	sequence-specific DNA binding
B7L66_10955	COG0582	viral genome integration into host DNA
B7L66_10975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B7L66_10980	COG0322	excinuclease ABC activity
B7L66_10990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B7L66_10995	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B7L66_11000	COG1663	tetraacyldisaccharide 4'-kinase activity
B7L66_11005	COG1132	(ABC) transporter
B7L66_11015	COG0811	peptide transport
B7L66_11030	COG1136	(ABC) transporter
B7L66_11035	COG4591	ABC-type transport system involved in lipoprotein release permease component
B7L66_11045	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B7L66_11050	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B7L66_11065	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B7L66_11090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B7L66_11095	COG0837	glucose binding
B7L66_11100	COG0363	glucosamine-6-phosphate deaminase activity
B7L66_11105	COG0129	dihydroxy-acid dehydratase activity
B7L66_11110	COG0800	Aldolase
B7L66_11180	COG0784	Response regulator, receiver
B7L66_11180	COG2205	protein histidine kinase activity
B7L66_11185	COG2183	response to ionizing radiation
B7L66_11195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L66_11195	COG0723	plastoquinol--plastocyanin reductase activity
B7L66_11210	COG3243	poly(R)-hydroxyalkanoic acid synthase
B7L66_11220	COG1183	phosphatidylcholine synthase activity
B7L66_11225	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_11240	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B7L66_11250	COG0668	transmembrane transport
B7L66_11255	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B7L66_11260	COG0590	tRNA wobble adenosine to inosine editing
B7L66_11265	COG1321	iron dependent repressor
B7L66_11270	COG1914	H( )-stimulated, divalent metal cation uptake system
B7L66_11285	COG0746	molybdenum cofactor guanylyltransferase activity
B7L66_11290	COG0303	'Molybdopterin
B7L66_11300	COG0708	Exodeoxyribonuclease III
B7L66_11335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B7L66_11340	COG0303	'Molybdopterin
B7L66_11345	COG1160	GTP binding
B7L66_11350	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B7L66_11360	COG1426	Protein conserved in bacteria
B7L66_11370	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B7L66_11375	COG0105	UTP biosynthetic process
B7L66_11385	COG1250	3-hydroxyacyl-CoA dehydrogenase
B7L66_11385	COG1024	Enoyl-CoA hydratase
B7L66_11390	COG0183	Belongs to the thiolase family
B7L66_11400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B7L66_11405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B7L66_11415	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B7L66_11425	COG1674	ftsk spoiiie
B7L66_11430	COG0492	ferredoxin-NADP+ reductase activity
B7L66_11440	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B7L66_11445	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B7L66_11450	COG0542	response to heat
B7L66_11455	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B7L66_11465	COG0482	sulfurtransferase activity
B7L66_11470	COG2915	High frequency lysogenization protein hflD homolog
B7L66_11500	COG5002	protein histidine kinase activity
B7L66_11520	COG0835	chemotaxis
B7L66_11520	COG0784	Response regulator, receiver
B7L66_11530	COG1558	bacterial-type flagellum-dependent cell motility
B7L66_11535	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B7L66_11540	COG1749	Flagellar hook protein flgE
B7L66_11545	COG4787	bacterial-type flagellum-dependent cell motility
B7L66_11555	COG4786	Flagellar basal body rod
B7L66_11560	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B7L66_11565	COG1706	bacterial-type flagellum-dependent cell motility
B7L66_11570	COG3951	Flagellar rod assembly protein muramidase FlgJ
B7L66_11570	COG1705	Flagellar rod assembly protein muramidase FlgJ
B7L66_11580	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B7L66_11590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B7L66_11595	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B7L66_11625	COG2201	protein-glutamate methylesterase activity
B7L66_11630	COG2204	response regulator
B7L66_11645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B7L66_11650	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_11655	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_11685	COG1677	Flagellar hook-basal body complex protein FliE
B7L66_11735	COG3190	flagellar
B7L66_11745	COG1987	bacterial-type flagellum assembly
B7L66_11750	COG1684	flagellar biosynthetic protein fliR
B7L66_11765	COG3300	MHYT domain
B7L66_11765	COG5001	Diguanylate cyclase
B7L66_11780	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B7L66_11790	COG0455	bacterial-type flagellum organization
B7L66_11810	COG0643	Histidine kinase
B7L66_11810	COG2198	Histidine kinase
B7L66_11825	COG0641	radical SAM
B7L66_11870	COG5002	protein histidine kinase activity
B7L66_11875	COG0745	RESPONSE REGULATOR receiver
B7L66_11960	COG2003	Belongs to the UPF0758 family
B7L66_11985	COG4191	Histidine kinase
B7L66_11985	COG0784	Response regulator, receiver
B7L66_11990	COG4191	Histidine kinase
B7L66_11990	COG0784	Response regulator, receiver
B7L66_12050	COG2963	transposase activity
B7L66_12165	COG3002	Belongs to the UPF0753 family
B7L66_12250	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B7L66_12255	COG1360	Flagellar Motor Protein
B7L66_12260	COG1192	Involved in chromosome partitioning
B7L66_12265	COG0835	chemotaxis
B7L66_12275	COG0745	RESPONSE REGULATOR receiver
B7L66_12280	COG2198	Histidine kinase
B7L66_12280	COG0643	Histidine kinase
B7L66_12285	COG0840	transmembrane signaling receptor activity
B7L66_12295	COG0840	transmembrane signaling receptor activity
B7L66_12295	COG0840	transmembrane signaling receptor activity
B7L66_12300	COG0840	transmembrane signaling receptor activity
B7L66_12315	COG0840	transmembrane signaling receptor activity
B7L66_12320	COG0840	transmembrane signaling receptor activity
B7L66_12325	COG0840	transmembrane signaling receptor activity
B7L66_12330	COG0840	transmembrane signaling receptor activity
B7L66_12340	COG0840	transmembrane signaling receptor activity
B7L66_12345	COG0840	transmembrane signaling receptor activity
B7L66_12350	COG0840	transmembrane signaling receptor activity
B7L66_12355	COG0840	transmembrane signaling receptor activity
B7L66_12360	COG0840	transmembrane signaling receptor activity
B7L66_12370	COG0835	chemotaxis
B7L66_12380	COG0840	transmembrane signaling receptor activity
B7L66_12390	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B7L66_12395	COG2201	protein-glutamate methylesterase activity
B7L66_12405	COG2267	carboxylic ester hydrolase activity
B7L66_12435	COG0318	PFAM AMP-dependent synthetase and ligase
B7L66_12440	COG1024	Enoyl-CoA hydratase
B7L66_12445	COG0784	Response regulator, receiver
B7L66_12445	COG2198	Histidine kinase
B7L66_12445	COG2205	protein histidine kinase activity
B7L66_12455	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B7L66_12465	COG3279	Response regulator of the LytR AlgR family
B7L66_12505	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B7L66_12515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B7L66_12520	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B7L66_12530	COG0505	Belongs to the CarA family
B7L66_12535	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B7L66_12540	COG2258	MOSC domain
B7L66_12545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B7L66_12590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B7L66_12610	COG0277	FAD linked oxidase domain protein
B7L66_12615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B7L66_12625	COG0531	amino acid
B7L66_12630	COG0531	amino acid
B7L66_12635	COG0235	Class ii aldolase
B7L66_12640	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B7L66_12645	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
B7L66_12660	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B7L66_12660	COG0140	phosphoribosyl-ATP diphosphatase activity
B7L66_12665	COG0107	imidazoleglycerol-phosphate synthase activity
B7L66_12670	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B7L66_12675	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B7L66_12680	COG0131	Imidazoleglycerol-phosphate dehydratase
B7L66_12680	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B7L66_12685	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B7L66_12690	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B7L66_12695	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B7L66_12705	COG0124	histidyl-tRNA synthetase
B7L66_12710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B7L66_12760	COG3210	domain, Protein
B7L66_12770	COG3210	domain, Protein
B7L66_12785	COG0726	polysaccharide deacetylase
B7L66_12785	COG1649	PFAM Uncharacterised BCR, COG1649
B7L66_12790	COG1215	transferase activity, transferring glycosyl groups
B7L66_12805	COG1012	belongs to the aldehyde dehydrogenase family
B7L66_12825	COG0167	dihydroorotate dehydrogenase activity
B7L66_12830	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B7L66_12835	COG0697	spore germination
B7L66_12845	COG1794	racemase activity, acting on amino acids and derivatives
B7L66_12860	COG0671	phosphoesterase, PA-phosphatase related
B7L66_12865	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B7L66_12880	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B7L66_12885	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L66_12895	COG5001	Diguanylate cyclase
B7L66_12895	COG3706	GGDEF domain
B7L66_12895	COG4251	negative regulation of phosphorylation
B7L66_12895	COG2203	Gaf domain
B7L66_12910	COG1472	Belongs to the glycosyl hydrolase 3 family
B7L66_12935	COG0166	Belongs to the GPI family
B7L66_12940	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B7L66_12945	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B7L66_12950	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B7L66_12970	COG1469	GTP cyclohydrolase I activity
B7L66_12975	COG0860	N-Acetylmuramoyl-L-alanine amidase
B7L66_12995	COG0477	Major facilitator Superfamily
B7L66_13000	COG2115	Belongs to the xylose isomerase family
B7L66_13005	COG1070	Carbohydrate kinase
B7L66_13015	COG1501	Belongs to the glycosyl hydrolase 31 family
B7L66_13065	COG0800	Aldolase
B7L66_13070	COG4948	Mandelate Racemase Muconate Lactonizing
B7L66_13080	COG3734	2-keto-3-deoxy-galactonokinase
B7L66_13085	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B7L66_13095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B7L66_13110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B7L66_13115	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B7L66_13130	COG0351	phosphomethylpyrimidine kinase
B7L66_13130	COG0352	thiamine-phosphate diphosphorylase activity
B7L66_13155	COG0583	DNA-binding transcription factor activity
B7L66_13160	COG1741	Belongs to the pirin family
B7L66_13180	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B7L66_13185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B7L66_13190	COG2137	regulation of response to DNA damage stimulus
B7L66_13200	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B7L66_13205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B7L66_13215	COG1546	Belongs to the CinA family
B7L66_13220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B7L66_13225	COG1923	regulation of RNA biosynthetic process
B7L66_13230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B7L66_13235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B7L66_13240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B7L66_13245	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B7L66_13250	COG1534	Rna-binding protein
B7L66_13265	COG1238	metal cluster binding
B7L66_13270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B7L66_13275	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B7L66_13280	COG2840	Smr protein MutS2
B7L66_13285	COG0585	pseudouridine synthase activity
B7L66_13290	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B7L66_13295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B7L66_13300	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B7L66_13305	COG0148	phosphopyruvate hydratase activity
B7L66_13315	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B7L66_13320	COG0504	CTP synthase activity
B7L66_13345	COG0306	phosphate transporter
B7L66_13360	COG1253	flavin adenine dinucleotide binding
B7L66_13375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B7L66_13380	COG0477	Major facilitator Superfamily
B7L66_13390	COG1136	(ABC) transporter
B7L66_13405	COG0438	transferase activity, transferring glycosyl groups
B7L66_13415	COG2264	protein methyltransferase activity
B7L66_13450	COG2244	polysaccharide biosynthetic process
B7L66_13505	COG1595	DNA-templated transcription, initiation
B7L66_13520	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B7L66_13530	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B7L66_13540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B7L66_13555	COG0784	Response regulator, receiver
B7L66_13555	COG4191	Histidine kinase
B7L66_13560	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
B7L66_13570	COG2205	protein histidine kinase activity
B7L66_13570	COG0784	Response regulator, receiver
B7L66_13570	COG5002	protein histidine kinase activity
B7L66_13595	COG0840	transmembrane signaling receptor activity
B7L66_13610	COG0583	DNA-binding transcription factor activity
B7L66_13615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B7L66_13620	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B7L66_13635	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B7L66_13640	COG0077	Prephenate dehydratase
B7L66_13640	COG1605	Chorismate mutase
B7L66_13645	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B7L66_13650	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B7L66_13655	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
B7L66_13700	COG1228	amidohydrolase
B7L66_13705	COG2986	histidine ammonia-lyase
B7L66_13715	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B7L66_13730	COG4993	Dehydrogenase
B7L66_13740	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B7L66_13755	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
B7L66_13760	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B7L66_13765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B7L66_13775	COG3115	cell septum assembly
B7L66_13785	COG0359	binds to the 23S rRNA
B7L66_13790	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B7L66_13795	COG0360	Binds together with S18 to 16S ribosomal RNA
B7L66_13800	COG0316	Belongs to the HesB IscA family
B7L66_13810	COG0017	Asparaginyl-tRNA synthetase
B7L66_13830	COG2808	Putative FMN-binding domain
B7L66_13895	COG0288	reversible hydration of carbon dioxide
B7L66_13900	COG0662	Cupin 2, conserved barrel domain protein
B7L66_13910	COG3844	kynureninase activity
B7L66_13915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L66_13925	COG2925	Exonuclease
B7L66_13950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B7L66_14000	COG0494	nUDIX hydrolase
B7L66_14010	COG1024	Enoyl-CoA hydratase
B7L66_14020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B7L66_14025	COG0659	secondary active sulfate transmembrane transporter activity
B7L66_14050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B7L66_14055	COG0573	inorganic phosphate transmembrane transporter activity
B7L66_14060	COG0581	inorganic phosphate transmembrane transporter activity
B7L66_14065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B7L66_14070	COG0704	Plays a role in the regulation of phosphate uptake
B7L66_14080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B7L66_14085	COG3706	GGDEF domain
B7L66_14090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B7L66_14100	COG0557	exoribonuclease II activity
B7L66_14120	COG1960	acyl-CoA dehydrogenase activity
B7L66_14125	COG1960	acyl-CoA dehydrogenase activity
B7L66_14130	COG1960	acyl-CoA dehydrogenase activity
B7L66_14135	COG1960	acyl-CoA dehydrogenase activity
B7L66_14145	COG1410	methionine synthase
B7L66_14145	COG0646	methionine synthase
B7L66_14150	COG0646	methionine synthase
B7L66_14150	COG1410	methionine synthase
B7L66_14160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B7L66_14185	COG2900	Belongs to the SlyX family
B7L66_14200	COG0386	Belongs to the glutathione peroxidase family
B7L66_14210	COG1725	Transcriptional regulator
B7L66_14215	COG1131	(ABC) transporter
B7L66_14245	COG1253	flavin adenine dinucleotide binding
B7L66_14265	COG2850	peptidyl-arginine hydroxylation
B7L66_14300	COG1132	(ABC) transporter
B7L66_14305	COG0583	DNA-binding transcription factor activity
B7L66_14335	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B7L66_14350	COG0484	heat shock protein binding
B7L66_14355	COG0443	Heat shock 70 kDa protein
B7L66_14360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B7L66_14365	COG1420	regulation of RNA biosynthetic process
B7L66_14370	COG0497	DNA recombination
B7L66_14380	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B7L66_14395	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B7L66_14510	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B7L66_14540	COG2022	thiamine diphosphate biosynthetic process
B7L66_14550	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B7L66_14555	COG3273	potassium ion transport
B7L66_14555	COG0471	metal ion transport
B7L66_14580	COG1970	mechanosensitive ion channel activity
B7L66_14600	COG3250	beta-galactosidase activity
B7L66_14605	COG4948	Mandelate Racemase Muconate Lactonizing
B7L66_14620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B7L66_14630	COG0308	aminopeptidase N
B7L66_14695	COG2895	sulfate adenylyltransferase (ATP) activity
B7L66_14695	COG0529	Catalyzes the synthesis of activated sulfate
B7L66_14700	COG0175	sulfate reduction
B7L66_14705	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B7L66_14710	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B7L66_14715	COG0175	sulfate reduction
B7L66_14755	COG1648	precorrin-2 dehydrogenase activity
B7L66_14755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B7L66_14770	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B7L66_14775	COG3588	fructose-bisphosphate aldolase
B7L66_14790	COG0469	pyruvate kinase activity
B7L66_14800	COG0126	phosphoglycerate kinase activity
B7L66_14825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B7L66_14835	COG3047	cAMP biosynthetic process
B7L66_14840	COG3047	cAMP biosynthetic process
B7L66_14850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L66_14850	COG3453	Protein conserved in bacteria
B7L66_14855	COG0725	ABC transporter, periplasmic molybdate-binding protein
B7L66_14860	COG4149	molybdate abc transporter
B7L66_14865	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B7L66_14900	COG1376	ErfK ybiS ycfS ynhG family protein
B7L66_14905	COG0739	heme binding
B7L66_14915	COG4773	Receptor
B7L66_14920	COG0596	Alpha beta hydrolase
B7L66_14925	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B7L66_14945	COG2304	oxidoreductase activity
B7L66_14965	COG0714	Associated with various cellular activities
B7L66_15000	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B7L66_15015	COG0254	rRNA binding
B7L66_15025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B7L66_15035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B7L66_15040	COG1758	RNA polymerase activity
B7L66_15045	COG0194	GDP metabolic process
B7L66_15050	COG1561	YicC-like family, N-terminal region
B7L66_15055	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B7L66_15065	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B7L66_15070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B7L66_15085	COG0006	proline dipeptidase activity
B7L66_15095	COG0006	proline dipeptidase activity
B7L66_15100	COG3079	Belongs to the UPF0149 family
B7L66_15120	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B7L66_15130	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B7L66_15140	COG2912	Transglutaminase-like superfamily
B7L66_15145	COG1773	rubredoxin
B7L66_15150	COG0352	thiamine-phosphate diphosphorylase activity
B7L66_15165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B7L66_15180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B7L66_15210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B7L66_15215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B7L66_15225	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_15235	COG0671	phosphoesterase, PA-phosphatase related
B7L66_15240	COG3781	membrane
B7L66_15250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B7L66_15255	COG0563	adenylate kinase activity
B7L66_15270	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B7L66_15280	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B7L66_15300	COG3710	Transcriptional regulator
B7L66_15305	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B7L66_15320	COG0840	transmembrane signaling receptor activity
B7L66_15325	COG0405	Gamma-glutamyltransferase
B7L66_15330	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B7L66_15350	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B7L66_15355	COG0473	3-isopropylmalate dehydrogenase activity
B7L66_15360	COG0066	3-isopropylmalate dehydratase activity
B7L66_15365	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B7L66_15385	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B7L66_15390	COG1538	Outer membrane efflux protein
B7L66_15395	COG1519	Transferase
B7L66_15405	COG1560	Kdo2-lipid A biosynthetic process
B7L66_15430	COG0280	phosphate acetyltransferase
B7L66_15430	COG0281	malic enzyme
B7L66_15435	COG1301	dicarboxylic acid transport
B7L66_15460	COG0583	DNA-binding transcription factor activity
B7L66_15470	COG0667	Aldo Keto reductase
B7L66_15485	COG2197	response regulator
B7L66_15490	COG1840	ABC-type Fe3 transport system, periplasmic component
B7L66_15495	COG0642	Histidine kinase
B7L66_15515	COG2851	Citrate transporter
B7L66_15520	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_15525	COG1609	Transcriptional regulator
B7L66_15530	COG2211	Major facilitator Superfamily
B7L66_15555	COG1162	GTPase activity
B7L66_15585	COG4773	Receptor
B7L66_15590	COG0726	polysaccharide deacetylase
B7L66_15595	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B7L66_15635	COG1307	EDD domain protein, DegV family
B7L66_15640	COG0242	peptide deformylase activity
B7L66_15670	COG0457	Tetratricopeptide repeat
B7L66_15675	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
B7L66_15680	COG1215	transferase activity, transferring glycosyl groups
B7L66_15685	COG1215	transferase activity, transferring glycosyl groups
B7L66_15700	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B7L66_15755	COG2188	Transcriptional regulator
B7L66_15765	COG1450	Type ii and iii secretion system protein
B7L66_15780	COG3166	PFAM Fimbrial assembly family protein
B7L66_15785	COG3156	type II secretion system protein K
B7L66_15790	COG4795	General secretion pathway protein
B7L66_15795	COG2165	general secretion pathway protein
B7L66_15800	COG4970	Tfp pilus assembly protein FimT
B7L66_15805	COG2165	general secretion pathway protein
B7L66_15810	COG1459	type II secretion system
B7L66_15820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B7L66_15825	COG1404	Belongs to the peptidase S8 family
B7L66_15830	COG5295	Hep Hag repeat protein
B7L66_15835	COG1404	Belongs to the peptidase S8 family
B7L66_15840	COG5295	Hep Hag repeat protein
B7L66_15850	COG0047	phosphoribosylformylglycinamidine synthase activity
B7L66_15850	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B7L66_15865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B7L66_15880	COG4974	Belongs to the 'phage' integrase family
B7L66_15895	COG0795	lipopolysaccharide-transporting ATPase activity
B7L66_15905	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B7L66_15920	COG0525	valine-tRNA ligase activity
B7L66_15950	COG1183	phosphatidylcholine synthase activity
B7L66_15960	COG0442	prolyl-tRNA aminoacylation
B7L66_15975	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B7L66_15980	COG1127	ABC transporter
B7L66_15985	COG3218	ABC-type transport auxiliary lipoprotein component
B7L66_15985	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B7L66_16020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B7L66_16025	COG0662	Cupin 2, conserved barrel domain protein
B7L66_16025	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
B7L66_16060	COG2086	electron transfer activity
B7L66_16075	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B7L66_16075	COG0546	phosphoglycolate phosphatase activity
B7L66_16080	COG0277	FAD linked oxidase domain protein
B7L66_16085	COG0300	oxidoreductase activity
B7L66_16095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B7L66_16115	COG2226	methyltransferase
B7L66_16125	COG3754	Rhamnan synthesis protein F
B7L66_16130	COG1216	Glycosyl transferase, family 2
B7L66_16130	COG0438	transferase activity, transferring glycosyl groups
B7L66_16135	COG0110	maltose O-acetyltransferase activity
B7L66_16150	COG0626	cystathionine gamma-synthase activity
B7L66_16180	COG0625	glutathione transferase activity
B7L66_16195	COG0513	Belongs to the DEAD box helicase family
B7L66_16205	COG4206	TonB-dependent receptor
B7L66_16210	COG0720	synthase
B7L66_16220	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B7L66_16230	COG1956	GAF domain-containing protein
B7L66_16240	COG2819	hydrolase of the alpha beta superfamily
B7L66_16255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B7L66_16260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B7L66_16275	COG0339	signal peptide processing
B7L66_16330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B7L66_16335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L66_16340	COG1136	(ABC) transporter
B7L66_16340	COG4591	ABC-type transport system involved in lipoprotein release permease component
B7L66_16345	COG0577	efflux transmembrane transporter activity
B7L66_16360	COG2204	response regulator
B7L66_16365	COG4191	Histidine kinase
B7L66_16370	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B7L66_16385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B7L66_16390	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B7L66_16395	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B7L66_16400	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B7L66_16405	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B7L66_16410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B7L66_16420	COG0356	it plays a direct role in the translocation of protons across the membrane
B7L66_16440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B7L66_16450	COG0508	dehydrogenase complex catalyzes the overall conversion of
B7L66_16490	COG2011	ABC-type metal ion transport system permease component
B7L66_16495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B7L66_16500	COG0697	spore germination
B7L66_16505	COG1666	GTP binding
B7L66_16515	COG2198	Histidine kinase
B7L66_16515	COG5002	protein histidine kinase activity
B7L66_16515	COG0784	Response regulator, receiver
B7L66_16535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B7L66_16540	COG1187	pseudouridine synthase activity
B7L66_16545	COG2813	Specifically methylates the guanine in position
B7L66_16565	COG2205	protein histidine kinase activity
B7L66_16565	COG2202	Pas domain
B7L66_16585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B7L66_16590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L66_16595	COG1522	sequence-specific DNA binding
B7L66_16655	COG0842	Transport permease protein
B7L66_16660	COG1131	(ABC) transporter
B7L66_16665	COG0025	NhaP-type Na H and K H
B7L66_16675	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B7L66_16680	COG1573	uracil-dna glycosylase
B7L66_16690	COG3384	dioxygenase
B7L66_16700	COG0583	DNA-binding transcription factor activity
B7L66_16710	COG0667	Aldo Keto reductase
B7L66_16725	COG3590	peptidase
B7L66_16745	COG0531	amino acid
B7L66_16760	COG2972	Histidine kinase
B7L66_16785	COG3685	Protein conserved in bacteria
B7L66_16790	COG3546	catalase activity
B7L66_16840	COG1271	oxidase subunit
B7L66_16845	COG1294	oxidase, subunit
B7L66_16860	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_16865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B7L66_16885	COG1132	(ABC) transporter
B7L66_16900	COG1063	alcohol dehydrogenase
B7L66_16975	COG0251	oxidation-reduction process
B7L66_16990	COG0840	transmembrane signaling receptor activity
B7L66_17010	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B7L66_17050	COG0024	Methionine aminopeptidase
B7L66_17085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B7L66_17175	COG3179	chitinase
B7L66_17375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B7L66_17380	COG1490	D-aminoacyl-tRNA deacylase activity
B7L66_17385	COG1560	Kdo2-lipid A biosynthetic process
B7L66_17440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B7L66_17440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B7L66_17445	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B7L66_17450	COG0242	peptide deformylase activity
B7L66_17455	COG1652	LysM domain
B7L66_17460	COG0758	DNA mediated transformation
B7L66_17480	COG1754	DNA topoisomerase type I activity
B7L66_17480	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L66_17485	COG0009	L-threonylcarbamoyladenylate synthase
B7L66_17500	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_17510	COG0616	signal peptide processing
B7L66_17515	COG0534	Mate efflux family protein
B7L66_17535	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B7L66_17540	COG0625	glutathione transferase activity
B7L66_17555	COG1252	NADH dehydrogenase
B7L66_17560	COG2860	membrane
B7L66_17565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B7L66_17570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B7L66_17575	COG2201	protein-glutamate methylesterase activity
B7L66_17580	COG2177	Part of the ABC transporter FtsEX involved in
B7L66_17585	COG2884	Cell division ATP-binding protein ftsE
B7L66_17590	COG0513	Belongs to the DEAD box helicase family
B7L66_17595	COG3118	belongs to the thioredoxin family
B7L66_17600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B7L66_17610	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
B7L66_17615	COG0583	DNA-binding transcription factor activity
B7L66_17660	COG1518	maintenance of DNA repeat elements
B7L66_17675	COG1652	LysM domain
B7L66_17680	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B7L66_17680	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B7L66_17685	COG1473	amidohydrolase
B7L66_17690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L66_17695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L66_17705	COG5383	Protein conserved in bacteria
B7L66_17755	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
B7L66_17760	COG3023	N-Acetylmuramoyl-L-alanine amidase
B7L66_17770	COG4948	Mandelate Racemase Muconate Lactonizing
B7L66_17780	COG0531	amino acid
B7L66_17795	COG4682	membrane
B7L66_17800	COG2133	pyrroloquinoline quinone binding
B7L66_17810	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B7L66_17815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B7L66_17820	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B7L66_17825	COG1610	YqeY-like protein
B7L66_17835	COG1295	ribonuclease BN
B7L66_17840	COG0358	DNA primase activity
B7L66_17855	COG0109	protoheme IX farnesyltransferase activity
B7L66_17885	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
B7L66_17895	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B7L66_17940	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B7L66_17945	COG0739	heme binding
B7L66_17950	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B7L66_17960	COG2223	nitrite transmembrane transporter activity
B7L66_17965	COG0708	Exodeoxyribonuclease III
B7L66_17970	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B7L66_17980	COG1192	Involved in chromosome partitioning
B7L66_17985	COG1475	DNA binding
B7L66_18005	COG0463	Glycosyl transferase, family 2
B7L66_18025	COG0756	dUTP diphosphatase activity
B7L66_18030	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B7L66_18035	COG2003	Belongs to the UPF0758 family
B7L66_18040	COG0018	arginyl-trna synthetase
B7L66_18055	COG4221	oxidoreductase activity
B7L66_18060	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B7L66_18060	COG2755	lipolytic protein G-D-S-L family
B7L66_18070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B7L66_18085	COG0606	chelatase, subunit chli
B7L66_18125	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B7L66_18130	COG1166	arginine decarboxylase activity
B7L66_18145	COG4943	cyclic-guanylate-specific phosphodiesterase activity
B7L66_18185	COG1690	Belongs to the RtcB family
B7L66_18220	COG1090	epimerase
B7L66_18225	COG0745	RESPONSE REGULATOR receiver
B7L66_18230	COG0642	Histidine kinase
B7L66_18260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B7L66_18285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B7L66_18290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B7L66_18305	COG0753	catalase activity
B7L66_18325	COG2197	response regulator
B7L66_18330	COG4585	Histidine kinase
B7L66_18335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L66_18340	COG1136	(ABC) transporter
B7L66_18365	COG0697	spore germination
B7L66_18385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L66_18390	COG0180	Tryptophanyl-tRNA synthetase
B7L66_18395	COG3237	CsbD-like
B7L66_18440	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B7L66_18455	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B7L66_18490	COG2205	protein histidine kinase activity
B7L66_18495	COG0745	RESPONSE REGULATOR receiver
B7L66_18505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B7L66_18535	COG1199	ATP-dependent helicase activity
B7L66_18550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B7L66_18615	COG0625	glutathione transferase activity
B7L66_18655	COG4555	ABC transporter
B7L66_18665	COG1476	TRANSCRIPTIONal
B7L66_18710	COG0633	Ferredoxin
B7L66_18710	COG0543	2 iron, 2 sulfur cluster binding
B7L66_18715	COG1131	(ABC) transporter
B7L66_18720	COG0842	Transport permease protein
B7L66_18730	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B7L66_18765	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B7L66_18775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B7L66_18795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B7L66_18795	COG0045	succinate-CoA ligase (ADP-forming) activity
B7L66_18795	COG1042	CoA-binding domain protein
B7L66_18800	COG2239	Acts as a magnesium transporter
B7L66_18820	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B7L66_18825	COG3387	PFAM Glycoside hydrolase 15-related
B7L66_18840	COG3100	YcgL domain-containing protein
B7L66_18845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B7L66_18855	COG0463	Glycosyl transferase, family 2
B7L66_18875	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_18910	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B7L66_18925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B7L66_18975	COG0408	coproporphyrinogen oxidase activity
B7L66_19015	COG2815	serine threonine protein kinase
B7L66_19015	COG0515	serine threonine protein kinase
B7L66_19020	COG0631	protein serine/threonine phosphatase activity
B7L66_19055	COG3501	Rhs element vgr protein
B7L66_19200	COG0210	DNA helicase
B7L66_19215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L66_19220	COG0583	DNA-binding transcription factor activity
B7L66_19225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B7L66_19240	COG2159	amidohydrolase
B7L66_19245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B7L66_19250	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B7L66_19260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L66_19280	COG0357	Ribosomal RNA small subunit methyltransferase G
B7L66_19285	COG3540	Alkaline phosphatase
B7L66_19295	COG2091	lysine biosynthetic process via aminoadipic acid
B7L66_19310	COG0708	Exodeoxyribonuclease III
B7L66_19315	COG1940	carbohydrate kinase activity
B7L66_19315	COG1846	Transcriptional regulator
B7L66_19325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B7L66_19335	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B7L66_19340	COG3162	membrane
B7L66_19350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B7L66_19380	COG3507	Belongs to the glycosyl hydrolase 43 family
B7L66_19400	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_19405	COG0179	Fumarylacetoacetate (FAA) hydrolase
B7L66_19415	COG4948	Mandelate Racemase Muconate Lactonizing
B7L66_19425	COG3254	rhamnose metabolic process
B7L66_19430	COG0738	Major facilitator superfamily
B7L66_19435	COG1414	Transcriptional regulator
B7L66_19440	COG1971	Probably functions as a manganese efflux pump
B7L66_19445	COG2205	protein histidine kinase activity
B7L66_19460	COG3459	Glycosyltransferase 36 associated
B7L66_19465	COG2211	Major facilitator Superfamily
B7L66_19470	COG3265	gluconokinase activity
B7L66_19480	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B7L66_19500	COG2911	Protein conserved in bacteria
B7L66_19505	COG0729	surface antigen
B7L66_19535	COG0752	glycyl-tRNA synthetase alpha subunit
B7L66_19540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B7L66_19555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B7L66_19555	COG0519	Catalyzes the synthesis of GMP from XMP
B7L66_19565	COG0805	protein transport
B7L66_19570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B7L66_19575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B7L66_19585	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B7L66_19610	COG2974	May be involved in recombination
B7L66_19625	COG2115	Belongs to the xylose isomerase family
B7L66_19635	COG3661	Belongs to the glycosyl hydrolase 67 family
B7L66_19645	COG4948	Mandelate Racemase Muconate Lactonizing
B7L66_19655	COG1472	Belongs to the glycosyl hydrolase 3 family
B7L66_19660	COG0246	Mannitol dehydrogenase
B7L66_19710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B7L66_19740	COG3386	PFAM SMP-30 Gluconolaconase
B7L66_19750	COG3250	beta-galactosidase activity
B7L66_19755	COG1904	glucuronate isomerase
B7L66_19770	COG3693	PFAM glycoside hydrolase, family 10
B7L66_19785	COG2211	Major facilitator Superfamily
B7L66_19855	COG2937	Belongs to the GPAT DAPAT family
B7L66_19890	COG0284	orotidine-5'-phosphate decarboxylase activity
B7L66_19895	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
B7L66_19905	COG3132	Protein of unknown function, DUF480
B7L66_19920	COG0210	DNA helicase
B7L66_19925	COG1435	thymidine kinase activity
B7L66_19940	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B7L66_19950	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B7L66_19985	COG3135	benzoate transporter
B7L66_20005	COG0676	glucose-6-phosphate 1-epimerase activity
B7L66_20015	COG3012	SEC-C Motif Domain Protein
B7L66_20020	COG0730	response to heat
B7L66_20040	COG0302	gtp cyclohydrolase
B7L66_20055	COG1566	PFAM secretion protein HlyD family protein
B7L66_20065	COG1289	transmembrane transporter activity
B7L66_20070	COG0477	Major facilitator Superfamily
B7L66_20080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L66_20100	COG4691	Plasmid stability protein
B7L66_20105	COG1487	ribonuclease activity
B7L66_20130	COG0564	pseudouridine synthase activity
B7L66_20175	COG0439	Biotin carboxylase
B7L66_20225	COG1074	ATP-dependent DNA helicase activity
B7L66_20230	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B7L66_20245	COG1127	ABC transporter
B7L66_20250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B7L66_20255	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B7L66_20270	COG2853	Lipoprotein
B7L66_20280	COG0386	Belongs to the glutathione peroxidase family
B7L66_20290	COG1322	Protein conserved in bacteria
B7L66_20295	COG0604	alcohol dehydrogenase
B7L66_20300	COG0583	DNA-binding transcription factor activity
B7L66_20315	COG0625	glutathione transferase activity
B7L66_20325	COG0531	amino acid
B7L66_20330	COG3537	Alpha-1,2-mannosidase
B7L66_20345	COG3706	GGDEF domain
B7L66_20350	COG3835	regulator
B7L66_20355	COG1929	Belongs to the glycerate kinase type-1 family
B7L66_20360	COG2271	Major facilitator Superfamily
B7L66_20375	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B7L66_20385	COG0861	Integral membrane protein TerC family
B7L66_20400	COG0584	glycerophosphoryl diester phosphodiesterase
B7L66_20415	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B7L66_20420	COG0726	polysaccharide deacetylase
B7L66_20425	COG0706	membrane insertase activity
B7L66_20430	COG0594	ribonuclease P activity
B7L66_20435	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B7L66_20445	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B7L66_20460	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B7L66_20465	COG0187	DNA topoisomerase II activity
B7L66_20475	COG0501	Belongs to the peptidase M48B family
B7L66_20505	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B7L66_20515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L66_20560	COG0793	Belongs to the peptidase S41A family
B7L66_20565	COG4942	peptidase
B7L66_20575	COG2234	aminopeptidase activity
B7L66_20585	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L66_20595	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L66_20600	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L66_20610	COG1064	alcohol dehydrogenase
B7L66_20615	COG0493	'glutamate synthase
B7L66_20620	COG0067	glutamate synthase
B7L66_20620	COG0070	glutamate synthase
B7L66_20620	COG0069	glutamate synthase activity
B7L66_20685	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B7L66_20690	COG0438	transferase activity, transferring glycosyl groups
B7L66_20690	COG0297	glycogen (starch) synthase activity
B7L66_20710	COG0367	asparagine synthase
B7L66_20740	COG1132	(ABC) transporter
B7L66_20865	COG1111	helicase
B7L66_20865	COG1205	dead DEAH box helicase
B7L66_20870	COG1272	protein, Hemolysin III
B7L66_20890	COG0300	oxidoreductase activity
B7L66_20895	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_20920	COG2249	NAD(P)H dehydrogenase (quinone) activity
B7L66_20990	COG3237	CsbD-like
B7L66_21040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B7L66_21050	COG0477	Major facilitator Superfamily
B7L66_21090	COG0714	Associated with various cellular activities
B7L66_21120	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B7L66_21130	COG4772	TonB-dependent receptor
B7L66_21140	COG0662	Cupin 2, conserved barrel domain protein
B7L66_21145	COG1012	belongs to the aldehyde dehydrogenase family
B7L66_21170	COG1304	FMN binding
B7L66_21185	COG4585	Histidine kinase
B7L66_21190	COG2197	response regulator
B7L66_21210	COG3710	Transcriptional regulator
B7L66_21215	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B7L66_21315	COG0366	Alpha amylase catalytic
B7L66_21320	COG0366	Alpha amylase catalytic
B7L66_21325	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B7L66_21365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B7L66_21385	COG1609	Transcriptional regulator
B7L66_21395	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
B7L66_21400	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_21410	COG2755	lipolytic protein G-D-S-L family
B7L66_21425	COG3186	Phenylalanine-4-hydroxylase
B7L66_21430	COG1522	sequence-specific DNA binding
B7L66_21440	COG1752	Esterase of the alpha-beta hydrolase superfamily
B7L66_21450	COG1119	ATPase activity
B7L66_21465	COG1125	glycine betaine transport
B7L66_21500	COG1396	sequence-specific DNA binding
B7L66_21525	COG0489	protein tyrosine kinase activity
B7L66_21530	COG2062	phosphohistidine phosphatase, SixA
B7L66_21540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L66_21585	COG1968	undecaprenyl-diphosphatase activity
B7L66_21590	COG0174	glutamine synthetase
B7L66_21595	COG0347	Belongs to the P(II) protein family
B7L66_21600	COG0004	ammonium transporteR
B7L66_21605	COG3852	Histidine kinase
B7L66_21610	COG2204	response regulator
B7L66_21625	COG2032	superoxide dismutase activity
B7L66_21630	COG2032	superoxide dismutase activity
B7L66_21650	COG0183	Belongs to the thiolase family
B7L66_21685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B7L66_21690	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B7L66_21695	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B7L66_21710	COG0028	Belongs to the TPP enzyme family
B7L66_21715	COG2205	protein histidine kinase activity
B7L66_21740	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B7L66_21755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B7L66_21765	COG0596	Alpha beta hydrolase
B7L66_21775	COG0318	PFAM AMP-dependent synthetase and ligase
B7L66_21780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B7L66_21795	COG1181	Belongs to the D-alanine--D-alanine ligase family
B7L66_21810	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B7L66_21820	COG0564	pseudouridine synthase activity
B7L66_21845	COG0339	signal peptide processing
B7L66_21875	COG0475	glutathione-regulated potassium exporter activity
B7L66_21880	COG0583	DNA-binding transcription factor activity
B7L66_21885	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B7L66_21890	COG2224	Isocitrate lyase
B7L66_21895	COG3706	GGDEF domain
B7L66_21925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B7L66_21930	COG1960	acyl-CoA dehydrogenase activity
B7L66_21990	COG0523	cobalamin synthesis protein
B7L66_22000	COG0697	spore germination
B7L66_22010	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B7L66_22015	COG1846	Transcriptional regulator
B7L66_22020	COG1764	response to oxidative stress
B7L66_22050	COG2130	NADP-dependent
B7L66_22065	COG1187	pseudouridine synthase activity
B7L66_22090	COG1643	Atp-dependent helicase
B7L66_22100	COG4807	Protein conserved in bacteria
B7L66_22105	COG2351	hydroxyisourate hydrolase activity
B7L66_22110	COG2072	flavoprotein involved in K transport
B7L66_22130	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B7L66_22165	COG1957	nucleoside hydrolase
B7L66_22175	COG2252	PERMEase
B7L66_22200	COG0084	hydrolase, TatD family'
B7L66_22215	COG0583	DNA-binding transcription factor activity
B7L66_22220	COG2814	Major facilitator Superfamily
B7L66_22245	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B7L66_22250	COG1902	pentaerythritol trinitrate reductase activity
B7L66_22270	COG0745	RESPONSE REGULATOR receiver
B7L66_22275	COG2205	protein histidine kinase activity
B7L66_22280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L66_22290	COG1538	Outer membrane efflux protein
B7L66_22300	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B7L66_22305	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B7L66_22310	COG0583	DNA-binding transcription factor activity
B7L66_22345	COG0702	epimerase
B7L66_22350	COG1733	regulation of RNA biosynthetic process
B7L66_22385	COG0129	dihydroxy-acid dehydratase activity
B7L66_22400	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B7L66_22455	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B7L66_22460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B7L66_22485	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B7L66_22500	COG3485	protocatechuate 3,4-dioxygenase
B7L66_22505	COG3485	protocatechuate 3,4-dioxygenase
B7L66_22515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B7L66_22520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B7L66_22530	COG1414	Transcriptional regulator
B7L66_22550	COG0445	tRNA wobble uridine modification
B7L66_22590	COG2267	carboxylic ester hydrolase activity
B7L66_22600	COG0156	8-amino-7-oxononanoate synthase activity
B7L66_22605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B7L66_22610	COG1040	competence protein
B7L66_22615	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B7L66_22705	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B7L66_22775	COG3264	Mechanosensitive ion channel
B7L66_22775	COG1511	domain protein
B7L66_22780	COG1368	sulfuric ester hydrolase activity
B7L66_22790	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B7L66_22795	COG2354	Protein conserved in bacteria
B7L66_22800	COG3706	GGDEF domain
B7L66_22800	COG0745	RESPONSE REGULATOR receiver
B7L66_22805	COG0297	glycogen (starch) synthase activity
B7L66_22810	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B7L66_22815	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B7L66_22840	COG0702	epimerase
B7L66_22845	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_22880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L66_22885	COG1028	Short-chain dehydrogenase reductase Sdr
B7L66_22895	COG0513	Belongs to the DEAD box helicase family
B7L66_22915	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B7L66_22925	COG3483	tryptophan 2,3-dioxygenase activity
B7L66_22930	COG3104	oligopeptide transport
B7L66_22955	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B7L66_22975	COG1320	monovalent cation:proton antiporter activity
B7L66_22980	COG2212	antiporter activity
B7L66_22990	COG0651	ATP synthesis coupled electron transport
B7L66_22995	COG1006	Multisubunit Na H antiporter MnhC subunit
B7L66_23000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B7L66_23000	COG2111	Na H antiporter
B7L66_23025	COG3179	chitinase
B7L66_23055	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B7L66_23060	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B7L66_23075	COG0456	acetyltransferase
B7L66_23080	COG1597	lipid kinase activity
B7L66_23105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B7L66_23110	COG0134	indole-3-glycerol-phosphate synthase activity
B7L66_23120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B7L66_23125	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B7L66_23135	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
B7L66_23140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B7L66_23145	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B7L66_23160	COG1051	belongs to the nudix hydrolase family
B7L66_23200	COG0316	Belongs to the HesB IscA family
B7L66_23220	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B7L66_23240	COG2814	Major facilitator Superfamily
B7L66_23245	COG0583	DNA-binding transcription factor activity
B7L66_23250	COG2814	Major facilitator Superfamily
B7L66_23255	COG1289	transmembrane transporter activity
B7L66_23265	COG0151	Belongs to the GarS family
B7L66_23275	COG0138	bifunctional purine biosynthesis protein purh
B7L66_23280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B7L66_23285	COG2267	carboxylic ester hydrolase activity
B7L66_23290	COG0671	phosphoesterase, PA-phosphatase related
B7L66_23290	COG2453	phosphatase
B7L66_23315	COG4589	Belongs to the CDS family
B7L66_23320	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
B7L66_23340	COG2264	protein methyltransferase activity
B7L66_23370	COG0439	Biotin carboxylase
B7L66_23380	COG0511	ligase activity, forming carbon-carbon bonds
B7L66_23385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B7L66_23395	COG1324	tolerance protein
B7L66_23425	COG0300	oxidoreductase activity
B7L66_23430	COG2356	endonuclease I
B7L66_23440	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B7L66_23445	COG0459	protein refolding
B7L66_23460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B7L66_23475	COG3386	PFAM SMP-30 Gluconolaconase
B7L66_23485	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B7L66_23490	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B7L66_23510	COG0778	Nitroreductase
B7L66_23515	COG2353	YceI-like domain
B7L66_23545	COG3052	prosthetic group binding
B7L66_23565	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
B7L66_23570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B7L66_23580	COG1802	Transcriptional regulator
B7L66_23635	COG4221	oxidoreductase activity
B7L66_23650	COG4221	oxidoreductase activity
B7L66_23660	COG0435	Glutathione S-transferase
B7L66_23685	COG2409	Drug exporters of the RND superfamily
B7L66_23695	COG1506	peptidase
B7L66_23695	COG0823	Involved in the tonB-independent uptake of proteins
B7L66_23710	COG3706	GGDEF domain
B7L66_23735	COG0697	spore germination
B7L66_23750	COG1113	amino acid transport
B7L66_23760	COG0598	Magnesium transport protein CorA
B7L66_23770	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
B7L66_23820	COG5001	Diguanylate cyclase
B7L66_23825	COG0840	transmembrane signaling receptor activity
B7L66_23830	COG5297	Belongs to the glycosyl hydrolase family 6
B7L66_23830	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B7L66_23835	COG0659	secondary active sulfate transmembrane transporter activity
B7L66_23845	COG3706	GGDEF domain
B7L66_23865	COG2943	transferase activity, transferring hexosyl groups
B7L66_23875	COG3275	phosphorelay sensor kinase activity
B7L66_23885	COG0181	hydroxymethylbilane synthase activity
B7L66_23915	COG1505	serine-type exopeptidase activity
B7L66_23920	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B7L66_23935	COG2832	Protein of unknown function (DUF454)
B7L66_23945	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B7L66_23955	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B7L66_23960	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B7L66_23965	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B7L66_23990	COG2226	methyltransferase
B7L66_23995	COG3300	MHYT domain
B7L66_23995	COG5001	Diguanylate cyclase
B7L66_24000	COG0308	aminopeptidase N
B7L66_24050	COG3284	Transcriptional regulator
B7L66_24060	COG1077	Cell shape determining protein MreB Mrl
B7L66_24065	COG1792	Involved in formation and maintenance of cell shape
B7L66_24080	COG0772	Belongs to the SEDS family
B7L66_24090	COG2951	lytic endotransglycosylase activity
B7L66_24095	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B7L66_24105	COG1686	Belongs to the peptidase S11 family
B7L66_24115	COG2921	Belongs to the UPF0250 family
B7L66_24120	COG0321	lipoyl(octanoyl) transferase activity
B7L66_24500	COG1674	ftsk spoiiie
B7L66_24605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L66_24615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L66_24615	COG0551	DNA topoisomerase type I activity
B7L66_24630	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B7L66_24695	COG0305	Participates in initiation and elongation during chromosome replication
B7L66_24800	COG4974	Belongs to the 'phage' integrase family
B7L66_24885	COG4644	lycopene metabolic process
B7L66_24890	COG2951	lytic endotransglycosylase activity
B7L66_24940	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B7L66_25050	COG2205	protein histidine kinase activity
B7L66_25050	COG0784	Response regulator, receiver
B7L66_25055	COG3437	response regulator, receiver
B7L66_25175	COG0489	protein tyrosine kinase activity
B7L66_25275	COG4456	Virulence-associated protein
B7L66_25280	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B7L66_25315	COG3318	Belongs to the UPF0149 family
B7L66_25315	COG3012	SEC-C Motif Domain Protein
B7L66_25335	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs