locus-tag	class	description
J172_00032	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J172_00041	COG2951	lytic endotransglycosylase activity
J172_00042	COG4644	lycopene metabolic process
J172_00072	COG2948	multi-organism process
J172_00073	COG3504	Conjugal transfer protein
J172_00094	COG4456	Virulence-associated protein
J172_00095	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J172_00103	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J172_00104	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J172_00106	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J172_00108	COG0187	DNA topoisomerase II activity
J172_00110	COG0501	Belongs to the peptidase M48B family
J172_00116	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
J172_00118	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J172_00127	COG0793	Belongs to the peptidase S41A family
J172_00128	COG4942	peptidase
J172_00130	COG2234	aminopeptidase activity
J172_00132	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J172_00133	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J172_00134	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J172_00135	COG1064	alcohol dehydrogenase
J172_00136	COG0493	'glutamate synthase
J172_00137	COG0070	glutamate synthase
J172_00137	COG0069	glutamate synthase activity
J172_00137	COG0067	glutamate synthase
J172_00141	COG2366	antibiotic biosynthetic process
J172_00146	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J172_00149	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
J172_00150	COG0297	glycogen (starch) synthase activity
J172_00150	COG0438	transferase activity, transferring glycosyl groups
J172_00154	COG0367	asparagine synthase
J172_00160	COG1132	(ABC) transporter
J172_00184	COG1205	dead DEAH box helicase
J172_00184	COG1111	helicase
J172_00185	COG1272	protein, Hemolysin III
J172_00188	COG0300	oxidoreductase activity
J172_00189	COG1028	Short-chain dehydrogenase reductase Sdr
J172_00194	COG2249	NAD(P)H dehydrogenase (quinone) activity
J172_00196	COG2963	transposase activity
J172_00205	COG3237	CsbD-like
J172_00214	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J172_00215	COG0477	Major facilitator Superfamily
J172_00223	COG0714	Associated with various cellular activities
J172_00229	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
J172_00231	COG4772	TonB-dependent receptor
J172_00233	COG0662	Cupin 2, conserved barrel domain protein
J172_00234	COG1012	belongs to the aldehyde dehydrogenase family
J172_00239	COG1304	FMN binding
J172_00241	COG4585	Histidine kinase
J172_00242	COG2197	response regulator
J172_00246	COG3710	Transcriptional regulator
J172_00247	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J172_00260	COG2963	transposase activity
J172_00262	COG0366	Alpha amylase catalytic
J172_00263	COG0366	Alpha amylase catalytic
J172_00264	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J172_00268	COG0657	acetylesterase activity
J172_00268	COG2755	lipolytic protein G-D-S-L family
J172_00270	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J172_00273	COG3507	Belongs to the glycosyl hydrolase 43 family
J172_00274	COG1609	Transcriptional regulator
J172_00275	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
J172_00276	COG1028	Short-chain dehydrogenase reductase Sdr
J172_00278	COG2755	lipolytic protein G-D-S-L family
J172_00281	COG3186	Phenylalanine-4-hydroxylase
J172_00282	COG1522	sequence-specific DNA binding
J172_00284	COG1752	Esterase of the alpha-beta hydrolase superfamily
J172_00286	COG1119	ATPase activity
J172_00289	COG1125	glycine betaine transport
J172_00292	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J172_00295	COG1396	sequence-specific DNA binding
J172_00299	COG0489	protein tyrosine kinase activity
J172_00300	COG2062	phosphohistidine phosphatase, SixA
J172_00302	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J172_00311	COG1968	undecaprenyl-diphosphatase activity
J172_00312	COG0174	glutamine synthetase
J172_00313	COG0347	Belongs to the P(II) protein family
J172_00314	COG0004	ammonium transporteR
J172_00315	COG3852	Histidine kinase
J172_00316	COG2204	response regulator
J172_00317	COG2032	superoxide dismutase activity
J172_00318	COG2032	superoxide dismutase activity
J172_00319	COG0346	lactoylglutathione lyase activity
J172_00321	COG0183	Belongs to the thiolase family
J172_00328	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J172_00329	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
J172_00330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J172_00332	COG0028	Belongs to the TPP enzyme family
J172_00333	COG2205	protein histidine kinase activity
J172_00338	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J172_00341	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J172_00343	COG0596	Alpha beta hydrolase
J172_00345	COG0318	PFAM AMP-dependent synthetase and ligase
J172_00347	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J172_00349	COG1181	Belongs to the D-alanine--D-alanine ligase family
J172_00351	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J172_00353	COG0564	pseudouridine synthase activity
J172_00358	COG0339	signal peptide processing
J172_00363	COG0475	glutathione-regulated potassium exporter activity
J172_00364	COG0583	DNA-binding transcription factor activity
J172_00365	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J172_00366	COG2224	Isocitrate lyase
J172_00367	COG3706	GGDEF domain
J172_00374	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J172_00375	COG1960	acyl-CoA dehydrogenase activity
J172_00386	COG0523	cobalamin synthesis protein
J172_00388	COG0697	spore germination
J172_00390	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
J172_00391	COG1846	Transcriptional regulator
J172_00392	COG1764	response to oxidative stress
J172_00397	COG2130	NADP-dependent
J172_00400	COG1187	pseudouridine synthase activity
J172_00403	COG1643	Atp-dependent helicase
J172_00404	COG4807	Protein conserved in bacteria
J172_00405	COG2351	hydroxyisourate hydrolase activity
J172_00406	COG2072	flavoprotein involved in K transport
J172_00410	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J172_00417	COG1957	nucleoside hydrolase
J172_00419	COG2252	PERMEase
J172_00423	COG0084	hydrolase, TatD family'
J172_00426	COG0583	DNA-binding transcription factor activity
J172_00427	COG2814	Major facilitator Superfamily
J172_00430	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J172_00431	COG1902	pentaerythritol trinitrate reductase activity
J172_00435	COG0745	RESPONSE REGULATOR receiver
J172_00436	COG2205	protein histidine kinase activity
J172_00437	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J172_00439	COG1538	Outer membrane efflux protein
J172_00441	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J172_00442	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J172_00443	COG0583	DNA-binding transcription factor activity
J172_00449	COG0702	epimerase
J172_00450	COG1733	regulation of RNA biosynthetic process
J172_00455	COG2963	transposase activity
J172_00457	COG0129	dihydroxy-acid dehydratase activity
J172_00460	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
J172_00471	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J172_00472	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J172_00477	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
J172_00478	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
J172_00480	COG3485	protocatechuate 3,4-dioxygenase
J172_00481	COG3485	protocatechuate 3,4-dioxygenase
J172_00483	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J172_00484	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J172_00486	COG1414	Transcriptional regulator
J172_00490	COG0445	tRNA wobble uridine modification
J172_00498	COG2267	carboxylic ester hydrolase activity
J172_00500	COG0156	8-amino-7-oxononanoate synthase activity
J172_00501	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J172_00502	COG1040	competence protein
J172_00503	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J172_00520	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J172_00534	COG3264	Mechanosensitive ion channel
J172_00534	COG1511	domain protein
J172_00535	COG1368	sulfuric ester hydrolase activity
J172_00536	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J172_00537	COG2354	Protein conserved in bacteria
J172_00538	COG3706	GGDEF domain
J172_00538	COG0745	RESPONSE REGULATOR receiver
J172_00539	COG0297	glycogen (starch) synthase activity
J172_00540	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J172_00541	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J172_00546	COG0702	epimerase
J172_00547	COG1028	Short-chain dehydrogenase reductase Sdr
J172_00553	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J172_00554	COG1028	Short-chain dehydrogenase reductase Sdr
J172_00556	COG0513	Belongs to the DEAD box helicase family
J172_00561	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J172_00563	COG3483	tryptophan 2,3-dioxygenase activity
J172_00564	COG3104	oligopeptide transport
J172_00568	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
J172_00571	COG1320	monovalent cation:proton antiporter activity
J172_00572	COG2212	antiporter activity
J172_00574	COG0651	ATP synthesis coupled electron transport
J172_00575	COG1006	Multisubunit Na H antiporter MnhC subunit
J172_00576	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J172_00576	COG2111	Na H antiporter
J172_00580	COG3179	chitinase
J172_00584	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J172_00585	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
J172_00588	COG0456	acetyltransferase
J172_00589	COG1597	lipid kinase activity
J172_00594	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J172_00595	COG0134	indole-3-glycerol-phosphate synthase activity
J172_00597	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J172_00598	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
J172_00600	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
J172_00601	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J172_00602	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J172_00605	COG1051	belongs to the nudix hydrolase family
J172_00612	COG0316	Belongs to the HesB IscA family
J172_00616	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
J172_00619	COG2814	Major facilitator Superfamily
J172_00620	COG0583	DNA-binding transcription factor activity
J172_00621	COG2814	Major facilitator Superfamily
J172_00622	COG1289	transmembrane transporter activity
J172_00623	COG0151	Belongs to the GarS family
J172_00625	COG0138	bifunctional purine biosynthesis protein purh
J172_00626	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J172_00627	COG2267	carboxylic ester hydrolase activity
J172_00628	COG2453	phosphatase
J172_00628	COG0671	phosphoesterase, PA-phosphatase related
J172_00633	COG4589	Belongs to the CDS family
J172_00634	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
J172_00639	COG2264	protein methyltransferase activity
J172_00642	COG0439	Biotin carboxylase
J172_00644	COG0511	ligase activity, forming carbon-carbon bonds
J172_00645	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
J172_00647	COG1324	tolerance protein
J172_00652	COG0300	oxidoreductase activity
J172_00653	COG2356	endonuclease I
J172_00654	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J172_00655	COG0459	protein refolding
J172_00658	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J172_00661	COG3386	PFAM SMP-30 Gluconolaconase
J172_00663	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
J172_00664	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J172_00667	COG0778	Nitroreductase
J172_00668	COG2353	YceI-like domain
J172_00673	COG3052	prosthetic group binding
J172_00677	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
J172_00679	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J172_00681	COG1802	Transcriptional regulator
J172_00691	COG2963	transposase activity
J172_00692	COG4221	oxidoreductase activity
J172_00695	COG4221	oxidoreductase activity
J172_00697	COG0435	Glutathione S-transferase
J172_00702	COG2409	Drug exporters of the RND superfamily
J172_00703	COG0823	Involved in the tonB-independent uptake of proteins
J172_00703	COG1506	peptidase
J172_00705	COG3706	GGDEF domain
J172_00709	COG0697	spore germination
J172_00713	COG1113	amino acid transport
J172_00715	COG0598	Magnesium transport protein CorA
J172_00717	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
J172_00724	COG5001	Diguanylate cyclase
J172_00725	COG0840	transmembrane signaling receptor activity
J172_00726	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J172_00726	COG5297	Belongs to the glycosyl hydrolase family 6
J172_00727	COG0659	secondary active sulfate transmembrane transporter activity
J172_00728	COG3706	GGDEF domain
J172_00731	COG2943	transferase activity, transferring hexosyl groups
J172_00733	COG3275	phosphorelay sensor kinase activity
J172_00735	COG0181	hydroxymethylbilane synthase activity
J172_00740	COG1505	serine-type exopeptidase activity
J172_00741	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J172_00744	COG2832	Protein of unknown function (DUF454)
J172_00746	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J172_00748	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
J172_00749	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
J172_00750	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
J172_00755	COG2226	methyltransferase
J172_00756	COG5001	Diguanylate cyclase
J172_00756	COG3300	MHYT domain
J172_00757	COG0308	aminopeptidase N
J172_00766	COG3284	Transcriptional regulator
J172_00768	COG1077	Cell shape determining protein MreB Mrl
J172_00769	COG1792	Involved in formation and maintenance of cell shape
J172_00772	COG0772	Belongs to the SEDS family
J172_00774	COG2951	lytic endotransglycosylase activity
J172_00775	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J172_00776	COG1686	Belongs to the peptidase S11 family
J172_00778	COG2921	Belongs to the UPF0250 family
J172_00779	COG0321	lipoyl(octanoyl) transferase activity
J172_00780	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J172_00783	COG0583	DNA-binding transcription factor activity
J172_00785	COG1056	cytidyltransferase-related domain
J172_00785	COG1051	belongs to the nudix hydrolase family
J172_00792	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
J172_00793	COG0673	inositol 2-dehydrogenase activity
J172_00794	COG2823	Periplasmic or secreted lipoprotein
J172_00795	COG4251	negative regulation of phosphorylation
J172_00796	COG0784	Response regulator, receiver
J172_00797	COG4191	Histidine kinase
J172_00798	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J172_00799	COG1028	Short-chain dehydrogenase reductase Sdr
J172_00809	COG1459	type II secretion system
J172_00820	COG3250	beta-galactosidase activity
J172_00826	COG1609	Transcriptional regulator
J172_00827	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J172_00828	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J172_00830	COG0617	tRNA 3'-terminal CCA addition
J172_00831	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
J172_00832	COG1012	belongs to the aldehyde dehydrogenase family
J172_00833	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J172_00835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J172_00839	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J172_00840	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J172_00843	COG2205	protein histidine kinase activity
J172_00844	COG0745	RESPONSE REGULATOR receiver
J172_00849	COG3791	Glutathione-dependent formaldehyde-activating
J172_00851	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J172_00853	COG0697	spore germination
J172_00855	COG0488	(ABC) transporter
J172_00857	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J172_00858	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J172_00860	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J172_00860	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J172_00865	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J172_00866	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J172_00867	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
J172_00871	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
J172_00872	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
J172_00873	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
J172_00874	COG2205	protein histidine kinase activity
J172_00875	COG0745	RESPONSE REGULATOR receiver
J172_00878	COG0277	FAD linked oxidase domain protein
J172_00879	COG1988	membrane-bound metal-dependent
J172_00880	COG0792	nuclease activity
J172_00887	COG2001	Belongs to the MraZ family
J172_00888	COG0275	rRNA processing
J172_00889	COG3116	cell division
J172_00891	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J172_00892	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J172_00893	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J172_00895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J172_00896	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J172_00897	COG1181	Belongs to the D-alanine--D-alanine ligase family
J172_00898	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J172_00901	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
J172_00903	COG0739	heme binding
J172_00904	COG0653	protein targeting
J172_00905	COG0494	nUDIX hydrolase
J172_00907	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J172_00910	COG1028	Short-chain dehydrogenase reductase Sdr
J172_00910	COG3321	synthase
J172_00910	COG0604	alcohol dehydrogenase
J172_00914	COG0366	Alpha amylase catalytic
J172_00920	COG2226	methyltransferase
J172_00921	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J172_00924	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
J172_00930	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J172_00932	COG4106	trans-aconitate 2-methyltransferase activity
J172_00933	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J172_00936	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J172_00937	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
J172_00938	COG0667	Aldo Keto reductase
J172_00940	COG4771	TonB-dependent receptor
J172_00945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J172_00946	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
J172_00948	COG2175	clavaminate synthase activity
J172_00950	COG4181	ATPase activity
J172_00953	COG0642	Histidine kinase
J172_00955	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J172_00959	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J172_00960	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J172_00963	COG3829	transcription factor binding
J172_00965	COG1116	anion transmembrane transporter activity
J172_00966	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J172_00968	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J172_00969	COG0431	NADPH-dependent FMN reductase
J172_00974	COG0747	negative chemotaxis
J172_00979	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J172_00980	COG2967	ApaG domain
J172_00981	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J172_00982	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
J172_00983	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J172_00984	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
J172_00987	COG0123	including yeast histone deacetylase and acetoin utilization protein
J172_00988	COG2096	Adenosyltransferase
J172_00990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J172_00991	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J172_00997	COG3384	dioxygenase
J172_00998	COG0583	DNA-binding transcription factor activity
J172_01001	COG1024	Enoyl-CoA hydratase
J172_01005	COG3386	PFAM SMP-30 Gluconolaconase
J172_01007	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
J172_01010	COG0697	spore germination
J172_01011	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J172_01014	COG0745	RESPONSE REGULATOR receiver
J172_01014	COG3706	GGDEF domain
J172_01015	COG0784	Response regulator, receiver
J172_01015	COG5002	protein histidine kinase activity
J172_01015	COG2205	protein histidine kinase activity
J172_01016	COG2197	response regulator
J172_01018	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J172_01020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J172_01021	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J172_01022	COG0583	DNA-binding transcription factor activity
J172_01023	COG3634	alkyl hydroperoxide reductase activity
J172_01025	COG2890	protein-(glutamine-N5) methyltransferase activity
J172_01029	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J172_01029	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J172_01035	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J172_01040	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J172_01041	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
J172_01044	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J172_01045	COG1404	Belongs to the peptidase S8 family
J172_01046	COG1404	Belongs to the peptidase S8 family
J172_01047	COG1404	Belongs to the peptidase S8 family
J172_01048	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J172_01054	COG1295	ribonuclease BN
J172_01055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J172_01056	COG1254	Belongs to the acylphosphatase family
J172_01059	COG0521	Mo-molybdopterin cofactor biosynthetic process
J172_01061	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J172_01062	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
J172_01064	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
J172_01065	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J172_01067	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J172_01068	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J172_01069	COG0193	aminoacyl-tRNA hydrolase activity
J172_01070	COG0012	GTP binding
J172_01074	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J172_01076	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J172_01077	COG0250	Participates in transcription elongation, termination and antitermination
J172_01078	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J172_01079	COG0081	regulation of translation
J172_01080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J172_01081	COG0222	ribosome binding
J172_01083	COG0085	RNA polymerase activity
J172_01084	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J172_01085	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J172_01086	COG0049	tRNA binding
J172_01087	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J172_01088	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J172_01089	COG0051	transcription antitermination factor activity, RNA binding
J172_01090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J172_01091	COG0088	Forms part of the polypeptide exit tunnel
J172_01092	COG0089	rRNA binding
J172_01093	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J172_01094	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J172_01095	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J172_01096	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J172_01097	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J172_01098	COG0255	Belongs to the universal ribosomal protein uL29 family
J172_01099	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J172_01100	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J172_01101	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J172_01102	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J172_01103	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J172_01104	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J172_01105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J172_01106	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J172_01107	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J172_01108	COG1841	ribosomal large subunit assembly
J172_01109	COG0200	Binds to the 23S rRNA
J172_01110	COG0201	protein transport
J172_01111	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J172_01112	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J172_01113	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J172_01114	COG0202	RNA polymerase activity
J172_01115	COG0203	ribosomal protein L17
J172_01116	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
J172_01118	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
J172_01120	COG0154	amidase activity
J172_01123	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J172_01124	COG0039	L-malate dehydrogenase activity
J172_01125	COG0625	glutathione transferase activity
J172_01127	COG0446	pyridine nucleotide-disulphide oxidoreductase
J172_01127	COG1902	pentaerythritol trinitrate reductase activity
J172_01128	COG0604	alcohol dehydrogenase
J172_01133	COG0156	8-amino-7-oxononanoate synthase activity
J172_01134	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
J172_01135	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
J172_01136	COG4208	sulfate ABC transporter
J172_01137	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J172_01139	COG1063	alcohol dehydrogenase
J172_01144	COG0406	alpha-ribazole phosphatase activity
J172_01145	COG0285	dihydrofolate synthase activity
J172_01149	COG2833	Protein of unknown function (DUF455)
J172_01151	COG3291	Pkd domain containing protein
J172_01153	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J172_01155	COG0671	phosphoesterase, PA-phosphatase related
J172_01156	COG0438	transferase activity, transferring glycosyl groups
J172_01158	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J172_01161	COG4783	chaperone-mediated protein folding
J172_01164	COG0473	3-isopropylmalate dehydrogenase activity
J172_01171	COG2963	transposase activity
J172_01194	COG2963	transposase activity
J172_01198	COG3852	Histidine kinase
J172_01201	COG0544	peptidyl-prolyl cis-trans isomerase activity
J172_01202	COG0740	serine-type endopeptidase activity
J172_01203	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J172_01209	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J172_01212	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J172_01214	COG0328	RNA-DNA hybrid ribonuclease activity
J172_01215	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J172_01216	COG0631	protein serine/threonine phosphatase activity
J172_01219	COG0859	PFAM glycosyl transferase family 9
J172_01220	COG3642	lipopolysaccharide core region biosynthetic process
J172_01221	COG1234	tRNA 3'-trailer cleavage
J172_01222	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J172_01223	COG0315	cyclic pyranopterin monophosphate synthase activity
J172_01224	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
J172_01225	COG0314	molybdopterin synthase activity
J172_01228	COG2963	transposase activity
J172_01236	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
J172_01237	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J172_01238	COG0537	adenosine 5'-monophosphoramidase activity
J172_01242	COG0714	Associated with various cellular activities
J172_01246	COG0424	maF-like protein
J172_01247	COG1399	metal-binding, possibly nucleic acid-binding protein
J172_01248	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J172_01249	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J172_01252	COG1028	Short-chain dehydrogenase reductase Sdr
J172_01253	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J172_01255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J172_01256	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J172_01261	COG3829	transcription factor binding
J172_01265	COG3609	addiction module antidote protein, CC2985 family
J172_01270	COG2373	Large extracellular alpha-helical protein
J172_01273	COG4953	penicillin-binding protein 1C
J172_01275	COG0678	peroxiredoxin activity
J172_01281	COG0330	HflC and HflK could
J172_01282	COG0330	HflC and HflK could
J172_01284	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J172_01285	COG0308	aminopeptidase N
J172_01287	COG1028	Short-chain dehydrogenase reductase Sdr
J172_01288	COG1309	transcriptional regulator
J172_01301	COG0328	RNA-DNA hybrid ribonuclease activity
J172_01301	COG0406	alpha-ribazole phosphatase activity
J172_01302	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J172_01304	COG3387	PFAM Glycoside hydrolase 15-related
J172_01305	COG1028	Short-chain dehydrogenase reductase Sdr
J172_01306	COG3537	Alpha-1,2-mannosidase
J172_01310	COG0492	ferredoxin-NADP+ reductase activity
J172_01315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J172_01316	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J172_01317	COG2080	2 iron, 2 sulfur cluster binding
J172_01324	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J172_01327	COG0587	DNA-directed DNA polymerase activity
J172_01330	COG1297	OPT oligopeptide transporter protein
J172_01333	COG0823	Involved in the tonB-independent uptake of proteins
J172_01333	COG1506	peptidase
J172_01336	COG1917	Cupin 2, conserved barrel domain protein
J172_01336	COG2207	Transcriptional regulator
J172_01341	COG0753	catalase activity
J172_01342	COG0656	L-ascorbic acid biosynthetic process
J172_01344	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J172_01344	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J172_01347	COG2814	Major facilitator Superfamily
J172_01350	COG2194	sulfuric ester hydrolase activity
J172_01353	COG0745	RESPONSE REGULATOR receiver
J172_01354	COG0642	Histidine kinase
J172_01356	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
J172_01357	COG2894	cell division
J172_01358	COG0850	regulation of cytokinetic process
J172_01360	COG4585	Histidine kinase
J172_01361	COG2197	response regulator
J172_01364	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
J172_01369	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
J172_01371	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
J172_01376	COG1946	Acyl-CoA thioesterase
J172_01379	COG0824	Thioesterase
J172_01380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J172_01381	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J172_01382	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J172_01383	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J172_01384	COG0268	Binds directly to 16S ribosomal RNA
J172_01386	COG0196	riboflavin kinase activity
J172_01387	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J172_01388	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J172_01389	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J172_01392	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J172_01393	COG1845	cytochrome c oxidase, subunit III
J172_01394	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
J172_01397	COG3152	Membrane
J172_01399	COG2207	Transcriptional regulator
J172_01400	COG0326	Molecular chaperone. Has ATPase activity
J172_01402	COG1366	Belongs to the anti-sigma-factor antagonist family
J172_01403	COG1366	Belongs to the anti-sigma-factor antagonist family
J172_01404	COG2172	sigma factor antagonist activity
J172_01409	COG4771	TonB-dependent receptor
J172_01411	COG5507	3-demethylubiquinone-9 3-methyltransferase
J172_01412	COG2205	protein histidine kinase activity
J172_01414	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J172_01415	COG2205	protein histidine kinase activity
J172_01415	COG3437	response regulator, receiver
J172_01415	COG4999	Histidine kinase
J172_01415	COG3850	Histidine kinase
J172_01416	COG0784	Response regulator, receiver
J172_01416	COG4191	Histidine kinase
J172_01421	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J172_01422	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J172_01424	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J172_01425	COG0228	four-way junction DNA binding
J172_01426	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J172_01427	COG0336	Belongs to the RNA methyltransferase TrmD family
J172_01428	COG0335	large ribosomal subunit rRNA binding
J172_01429	COG0534	Mate efflux family protein
J172_01430	COG0534	Mate efflux family protein
J172_01434	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
J172_01436	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J172_01439	COG3209	COG3209 Rhs family protein
J172_01443	COG3250	beta-galactosidase activity
J172_01444	COG3867	Arabinogalactan endo-beta-1,4-galactanase
J172_01448	COG1960	acyl-CoA dehydrogenase activity
J172_01449	COG1024	Enoyl-CoA hydratase
J172_01453	COG1250	3-hydroxyacyl-CoA dehydrogenase
J172_01453	COG1024	Enoyl-CoA hydratase
J172_01456	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J172_01457	COG0481	GTPase activity
J172_01460	COG0571	ribonuclease III activity
J172_01461	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J172_01462	COG1381	Involved in DNA repair and RecF pathway recombination
J172_01464	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J172_01466	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J172_01467	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
J172_01468	COG3046	protein related to deoxyribodipyrimidine photolyase
J172_01469	COG1472	Belongs to the glycosyl hydrolase 3 family
J172_01471	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
J172_01472	COG1278	Cold shock
J172_01473	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J172_01475	COG1201	RNA secondary structure unwinding
J172_01476	COG1793	dna ligase
J172_01478	COG1793	dna ligase
J172_01478	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J172_01481	COG3706	GGDEF domain
J172_01481	COG0745	RESPONSE REGULATOR receiver
J172_01484	COG0183	Belongs to the thiolase family
J172_01488	COG1451	nucleotide metabolic process
J172_01489	COG5487	UPF0391 membrane protein
J172_01491	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J172_01494	COG1077	Cell shape determining protein MreB Mrl
J172_01495	COG1047	Peptidyl-prolyl cis-trans
J172_01497	COG2824	Alkylphosphonate utilization operon protein PhnA
J172_01498	COG1902	pentaerythritol trinitrate reductase activity
J172_01499	COG2814	Major facilitator Superfamily
J172_01506	COG0392	lysyltransferase activity
J172_01506	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
J172_01509	COG0251	oxidation-reduction process
J172_01510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J172_01513	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J172_01518	COG1595	DNA-templated transcription, initiation
J172_01521	COG2878	Part of a membrane complex involved in electron transport
J172_01523	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J172_01523	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J172_01526	COG1131	(ABC) transporter
J172_01527	COG0346	lactoylglutathione lyase activity
J172_01528	COG0833	amino acid
J172_01529	COG2040	homocysteine
J172_01531	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J172_01535	COG1695	Transcriptional regulator
J172_01542	COG0825	malonyl-CoA metabolic process
J172_01544	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J172_01545	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J172_01546	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J172_01547	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J172_01548	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J172_01551	COG0750	zinc metalloprotease
J172_01552	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J172_01553	COG0575	Belongs to the CDS family
J172_01554	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J172_01555	COG0233	cytoplasmic translational termination
J172_01556	COG0528	UMP kinase activity
J172_01557	COG0745	RESPONSE REGULATOR receiver
J172_01557	COG3706	GGDEF domain
J172_01558	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J172_01559	COG0052	Belongs to the universal ribosomal protein uS2 family
J172_01566	COG0024	Methionine aminopeptidase
J172_01567	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
J172_01569	COG1393	Belongs to the ArsC family
J172_01570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J172_01571	COG0367	asparagine synthase
J172_01573	COG4774	siderophore transport
J172_01577	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J172_01583	COG1566	PFAM secretion protein HlyD family protein
J172_01584	COG2814	Major facilitator Superfamily
J172_01588	COG3104	oligopeptide transport
J172_01594	COG0339	signal peptide processing
J172_01595	COG0386	Belongs to the glutathione peroxidase family
J172_01606	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J172_01607	COG0084	hydrolase, TatD family'
J172_01610	COG1960	acyl-CoA dehydrogenase activity
J172_01613	COG0367	asparagine synthase
J172_01615	COG0305	Participates in initiation and elongation during chromosome replication
J172_01616	COG0415	Belongs to the DNA photolyase family
J172_01619	COG0583	DNA-binding transcription factor activity
J172_01626	COG3706	GGDEF domain
J172_01628	COG3706	GGDEF domain
J172_01655	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J172_01658	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J172_01660	COG0497	DNA recombination
J172_01661	COG1420	regulation of RNA biosynthetic process
J172_01662	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J172_01663	COG0443	Heat shock 70 kDa protein
J172_01664	COG0484	heat shock protein binding
J172_01666	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
J172_01672	COG0583	DNA-binding transcription factor activity
J172_01673	COG1132	(ABC) transporter
J172_01680	COG2850	peptidyl-arginine hydroxylation
J172_01684	COG1253	flavin adenine dinucleotide binding
J172_01690	COG1131	(ABC) transporter
J172_01691	COG1725	Transcriptional regulator
J172_01693	COG0386	Belongs to the glutathione peroxidase family
J172_01696	COG2900	Belongs to the SlyX family
J172_01701	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J172_01703	COG1410	methionine synthase
J172_01703	COG0646	methionine synthase
J172_01704	COG0646	methionine synthase
J172_01704	COG1410	methionine synthase
J172_01706	COG1960	acyl-CoA dehydrogenase activity
J172_01709	COG0557	exoribonuclease II activity
J172_01711	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J172_01712	COG3706	GGDEF domain
J172_01713	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J172_01715	COG0704	Plays a role in the regulation of phosphate uptake
J172_01716	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J172_01717	COG0581	inorganic phosphate transmembrane transporter activity
J172_01718	COG0573	inorganic phosphate transmembrane transporter activity
J172_01719	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J172_01724	COG0659	secondary active sulfate transmembrane transporter activity
J172_01725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J172_01727	COG1024	Enoyl-CoA hydratase
J172_01729	COG0494	nUDIX hydrolase
J172_01737	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J172_01737	COG0116	Belongs to the methyltransferase superfamily
J172_01738	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J172_01742	COG2925	Exonuclease
J172_01743	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J172_01744	COG3844	kynureninase activity
J172_01746	COG0662	Cupin 2, conserved barrel domain protein
J172_01747	COG0288	reversible hydration of carbon dioxide
J172_01759	COG2808	Putative FMN-binding domain
J172_01763	COG0017	Asparaginyl-tRNA synthetase
J172_01764	COG0316	Belongs to the HesB IscA family
J172_01765	COG0360	Binds together with S18 to 16S ribosomal RNA
J172_01766	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J172_01767	COG0359	binds to the 23S rRNA
J172_01769	COG3115	cell septum assembly
J172_01771	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J172_01772	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J172_01773	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
J172_01775	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
J172_01777	COG4993	Dehydrogenase
J172_01779	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
J172_01781	COG2986	histidine ammonia-lyase
J172_01782	COG1228	amidohydrolase
J172_01790	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
J172_01791	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J172_01792	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
J172_01793	COG0077	Prephenate dehydratase
J172_01793	COG1605	Chorismate mutase
J172_01794	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J172_01797	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J172_01798	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J172_01799	COG0583	DNA-binding transcription factor activity
J172_01804	COG2963	transposase activity
J172_01810	COG0840	transmembrane signaling receptor activity
J172_01814	COG0745	RESPONSE REGULATOR receiver
J172_01815	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
J172_01816	COG0784	Response regulator, receiver
J172_01816	COG4191	Histidine kinase
J172_01819	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J172_01821	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
J172_01823	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J172_01826	COG1595	DNA-templated transcription, initiation
J172_01837	COG2244	polysaccharide biosynthetic process
J172_01843	COG2264	protein methyltransferase activity
J172_01845	COG0438	transferase activity, transferring glycosyl groups
J172_01848	COG1136	(ABC) transporter
J172_01850	COG0477	Major facilitator Superfamily
J172_01851	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J172_01854	COG1253	flavin adenine dinucleotide binding
J172_01856	COG0306	phosphate transporter
J172_01861	COG0504	CTP synthase activity
J172_01862	COG2877	3-deoxy-8-phosphooctulonate synthase activity
J172_01864	COG0148	phosphopyruvate hydratase activity
J172_01865	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
J172_01866	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J172_01867	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J172_01868	COG0585	pseudouridine synthase activity
J172_01869	COG2840	Smr protein MutS2
J172_01870	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
J172_01871	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J172_01872	COG1238	metal cluster binding
J172_01876	COG1534	Rna-binding protein
J172_01877	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
J172_01878	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J172_01879	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J172_01880	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J172_01881	COG1923	regulation of RNA biosynthetic process
J172_01882	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J172_01883	COG1546	Belongs to the CinA family
J172_01885	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J172_01886	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J172_01887	COG2137	regulation of response to DNA damage stimulus
J172_01888	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J172_01889	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
J172_01892	COG1741	Belongs to the pirin family
J172_01893	COG0583	DNA-binding transcription factor activity
J172_01898	COG0352	thiamine-phosphate diphosphorylase activity
J172_01898	COG0351	phosphomethylpyrimidine kinase
J172_01901	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
J172_01902	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J172_01905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J172_01907	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
J172_01908	COG3734	2-keto-3-deoxy-galactonokinase
J172_01910	COG4948	Mandelate Racemase Muconate Lactonizing
J172_01911	COG0800	Aldolase
J172_01919	COG1501	Belongs to the glycosyl hydrolase 31 family
J172_01921	COG1070	Carbohydrate kinase
J172_01922	COG2115	Belongs to the xylose isomerase family
J172_01923	COG0477	Major facilitator Superfamily
J172_01926	COG0860	N-Acetylmuramoyl-L-alanine amidase
J172_01927	COG1469	GTP cyclohydrolase I activity
J172_01933	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J172_01934	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
J172_01935	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
J172_01936	COG0166	Belongs to the GPI family
J172_01940	COG1472	Belongs to the glycosyl hydrolase 3 family
J172_01942	COG5001	Diguanylate cyclase
J172_01942	COG4251	negative regulation of phosphorylation
J172_01942	COG3706	GGDEF domain
J172_01942	COG2203	Gaf domain
J172_01943	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J172_01944	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
J172_01946	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J172_01947	COG0671	phosphoesterase, PA-phosphatase related
J172_01949	COG1794	racemase activity, acting on amino acids and derivatives
J172_01950	COG0697	spore germination
J172_01951	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J172_01952	COG0167	dihydroorotate dehydrogenase activity
J172_01955	COG1012	belongs to the aldehyde dehydrogenase family
J172_01958	COG1215	transferase activity, transferring glycosyl groups
J172_01959	COG0726	polysaccharide deacetylase
J172_01959	COG1649	PFAM Uncharacterised BCR, COG1649
J172_01962	COG3210	domain, Protein
J172_01963	COG3210	domain, Protein
J172_01972	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J172_01973	COG0124	histidyl-tRNA synthetase
J172_01975	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J172_01976	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J172_01977	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J172_01978	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
J172_01978	COG0131	Imidazoleglycerol-phosphate dehydratase
J172_01979	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J172_01980	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J172_01981	COG0107	imidazoleglycerol-phosphate synthase activity
J172_01982	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J172_01982	COG0140	phosphoribosyl-ATP diphosphatase activity
J172_01985	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
J172_01986	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
J172_01987	COG0235	Class ii aldolase
J172_01988	COG0531	amino acid
J172_01989	COG0531	amino acid
J172_01991	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J172_01992	COG0277	FAD linked oxidase domain protein
J172_01996	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J172_02005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J172_02006	COG2258	MOSC domain
J172_02007	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J172_02008	COG0505	Belongs to the CarA family
J172_02010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J172_02011	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J172_02013	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J172_02021	COG3279	Response regulator of the LytR AlgR family
J172_02022	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
J172_02023	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J172_02025	COG2198	Histidine kinase
J172_02025	COG0784	Response regulator, receiver
J172_02025	COG2205	protein histidine kinase activity
J172_02026	COG1024	Enoyl-CoA hydratase
J172_02027	COG0318	PFAM AMP-dependent synthetase and ligase
J172_02033	COG2267	carboxylic ester hydrolase activity
J172_02035	COG2201	protein-glutamate methylesterase activity
J172_02036	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
J172_02038	COG0840	transmembrane signaling receptor activity
J172_02039	COG0840	transmembrane signaling receptor activity
J172_02040	COG0840	transmembrane signaling receptor activity
J172_02041	COG0840	transmembrane signaling receptor activity
J172_02042	COG0840	transmembrane signaling receptor activity
J172_02043	COG0840	transmembrane signaling receptor activity
J172_02044	COG0840	transmembrane signaling receptor activity
J172_02046	COG0840	transmembrane signaling receptor activity
J172_02047	COG0840	transmembrane signaling receptor activity
J172_02047	COG0840	transmembrane signaling receptor activity
J172_02049	COG0840	transmembrane signaling receptor activity
J172_02050	COG2198	Histidine kinase
J172_02050	COG0643	Histidine kinase
J172_02051	COG0745	RESPONSE REGULATOR receiver
J172_02053	COG0835	chemotaxis
J172_02054	COG1192	Involved in chromosome partitioning
J172_02055	COG1360	Flagellar Motor Protein
J172_02056	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
J172_02069	COG2963	transposase activity
J172_02075	COG0641	radical SAM
J172_02078	COG0643	Histidine kinase
J172_02078	COG2198	Histidine kinase
J172_02082	COG0455	bacterial-type flagellum organization
J172_02084	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J172_02087	COG3300	MHYT domain
J172_02087	COG5001	Diguanylate cyclase
J172_02088	COG5001	Diguanylate cyclase
J172_02088	COG3300	MHYT domain
J172_02089	COG1684	flagellar biosynthetic protein fliR
J172_02090	COG1987	bacterial-type flagellum assembly
J172_02093	COG3190	flagellar
J172_02103	COG1677	Flagellar hook-basal body complex protein FliE
J172_02110	COG1028	Short-chain dehydrogenase reductase Sdr
J172_02111	COG1028	Short-chain dehydrogenase reductase Sdr
J172_02112	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J172_02115	COG2204	response regulator
J172_02116	COG2201	protein-glutamate methylesterase activity
J172_02122	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
J172_02123	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J172_02124	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J172_02126	COG1705	Flagellar rod assembly protein muramidase FlgJ
J172_02126	COG3951	Flagellar rod assembly protein muramidase FlgJ
J172_02127	COG1706	bacterial-type flagellum-dependent cell motility
J172_02128	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
J172_02129	COG4786	Flagellar basal body rod
J172_02130	COG4787	bacterial-type flagellum-dependent cell motility
J172_02131	COG1749	Flagellar hook protein flgE
J172_02132	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
J172_02133	COG1558	bacterial-type flagellum-dependent cell motility
J172_02135	COG0835	chemotaxis
J172_02135	COG0784	Response regulator, receiver
J172_02139	COG5002	protein histidine kinase activity
J172_02145	COG2915	High frequency lysogenization protein hflD homolog
J172_02146	COG0482	sulfurtransferase activity
J172_02148	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
J172_02149	COG0542	response to heat
J172_02150	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J172_02151	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
J172_02153	COG0492	ferredoxin-NADP+ reductase activity
J172_02154	COG1674	ftsk spoiiie
J172_02156	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
J172_02158	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J172_02160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J172_02162	COG0183	Belongs to the thiolase family
J172_02163	COG1024	Enoyl-CoA hydratase
J172_02163	COG1250	3-hydroxyacyl-CoA dehydrogenase
J172_02165	COG0105	UTP biosynthetic process
J172_02166	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J172_02168	COG1426	Protein conserved in bacteria
J172_02170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J172_02171	COG1160	GTP binding
J172_02172	COG0303	'Molybdopterin
J172_02173	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J172_02180	COG0708	Exodeoxyribonuclease III
J172_02182	COG0303	'Molybdopterin
J172_02183	COG0746	molybdenum cofactor guanylyltransferase activity
J172_02186	COG1914	H( )-stimulated, divalent metal cation uptake system
J172_02187	COG1321	iron dependent repressor
J172_02188	COG0590	tRNA wobble adenosine to inosine editing
J172_02189	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
J172_02190	COG0668	transmembrane transport
J172_02192	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
J172_02195	COG1028	Short-chain dehydrogenase reductase Sdr
J172_02196	COG1183	phosphatidylcholine synthase activity
J172_02198	COG3243	poly(R)-hydroxyalkanoic acid synthase
J172_02201	COG0723	plastoquinol--plastocyanin reductase activity
J172_02201	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J172_02203	COG2183	response to ionizing radiation
J172_02204	COG0784	Response regulator, receiver
J172_02204	COG2205	protein histidine kinase activity
J172_02217	COG0800	Aldolase
J172_02218	COG0129	dihydroxy-acid dehydratase activity
J172_02219	COG0363	glucosamine-6-phosphate deaminase activity
J172_02220	COG0837	glucose binding
J172_02221	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J172_02226	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
J172_02229	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J172_02230	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
J172_02232	COG4591	ABC-type transport system involved in lipoprotein release permease component
J172_02233	COG1136	(ABC) transporter
J172_02236	COG0811	peptide transport
J172_02238	COG1132	(ABC) transporter
J172_02239	COG1663	tetraacyldisaccharide 4'-kinase activity
J172_02240	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
J172_02241	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J172_02243	COG0322	excinuclease ABC activity
J172_02244	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J172_02248	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J172_02249	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J172_02253	COG2963	transposase activity
J172_02254	COG0582	viral genome integration into host DNA
J172_02256	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
J172_02262	COG1530	ribonuclease E activity
J172_02264	COG3064	Membrane
J172_02265	COG0428	transporter
J172_02267	COG2154	pterin-4-alpha-carbinolamine dehydratase
J172_02268	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
J172_02268	COG0316	Belongs to the HesB IscA family
J172_02279	COG1028	Short-chain dehydrogenase reductase Sdr
J172_02284	COG2963	transposase activity
J172_02286	COG1238	metal cluster binding
J172_02292	COG3279	Response regulator of the LytR AlgR family
J172_02300	COG4566	intracellular signal transduction
J172_02302	COG5001	Diguanylate cyclase
J172_02305	COG3685	Protein conserved in bacteria
J172_02309	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J172_02309	COG1648	precorrin-2 dehydrogenase activity
J172_02312	COG2814	Major facilitator Superfamily
J172_02315	COG1335	isochorismatase
J172_02318	COG2197	response regulator
J172_02321	COG0583	DNA-binding transcription factor activity
J172_02322	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J172_02323	COG3002	Belongs to the UPF0753 family
J172_02325	COG2963	transposase activity
J172_02326	COG1396	sequence-specific DNA binding
J172_02327	COG5489	Protein of unknown function (DUF736)
J172_02328	COG2003	Belongs to the UPF0758 family
J172_02333	COG0582	viral genome integration into host DNA
J172_02336	COG4774	siderophore transport
J172_02340	COG2336	PFAM SpoVT AbrB
J172_02345	COG4206	TonB-dependent receptor
J172_02350	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
J172_02350	COG2273	Hydrolase Family 16
J172_02355	COG2274	protein secretion by the type I secretion system
J172_02357	COG1192	Involved in chromosome partitioning
J172_02365	COG0551	DNA topoisomerase type I activity
J172_02365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J172_02367	COG0270	DNA (cytosine-5-)-methyltransferase activity
J172_02379	COG4804	nuclease activity
J172_02380	COG2963	transposase activity
J172_02382	COG5006	permease, DMT superfamily
J172_02385	COG2249	NAD(P)H dehydrogenase (quinone) activity
J172_02387	COG3938	Belongs to the proline racemase family
J172_02388	COG0655	NAD(P)H dehydrogenase (quinone) activity
J172_02390	COG2807	transmembrane transport
J172_02391	COG2207	Transcriptional regulator
J172_02421	COG0210	DNA helicase
J172_02437	COG2084	Dehydrogenase
J172_02442	COG2003	Belongs to the UPF0758 family
J172_02449	COG0582	viral genome integration into host DNA
J172_02450	COG0519	Catalyzes the synthesis of GMP from XMP
J172_02450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J172_02452	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J172_02454	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J172_02454	COG0475	glutathione-regulated potassium exporter activity
J172_02455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J172_02457	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J172_02458	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
J172_02460	COG0776	regulation of translation
J172_02461	COG0539	negative regulation of cytoplasmic translation
J172_02462	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J172_02463	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J172_02466	COG2957	Belongs to the agmatine deiminase family
J172_02467	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J172_02472	COG0395	ABC-type sugar transport system, permease component
J172_02473	COG1175	transmembrane transport
J172_02479	COG2350	Protein conserved in bacteria
J172_02480	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
J172_02481	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J172_02482	COG1187	pseudouridine synthase activity
J172_02486	COG0436	Aminotransferase
J172_02487	COG4133	protoheme IX ABC transporter activity
J172_02491	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
J172_02492	COG1138	Cytochrome C-type biogenesis protein
J172_02496	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J172_02497	COG1278	Cold shock
J172_02498	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
J172_02499	COG4988	ABC transporter
J172_02501	COG1294	oxidase, subunit
J172_02506	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J172_02507	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J172_02509	COG0165	Argininosuccinate lyase
J172_02510	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J172_02512	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J172_02515	COG0137	argininosuccinate synthase activity
J172_02516	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J172_02518	COG0215	cysteine-tRNA ligase activity
J172_02519	COG2166	iron-sulfur cluster assembly
J172_02521	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J172_02522	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J172_02523	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J172_02528	COG4302	ethanolamine ammonia-lyase activity
J172_02534	COG2963	transposase activity
J172_02540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J172_02541	COG0402	S-adenosylhomocysteine deaminase activity
J172_02543	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J172_02544	COG1509	lysine 2,3-aminomutase activity
J172_02545	COG5001	Diguanylate cyclase
J172_02545	COG3300	MHYT domain
J172_02548	COG0483	inositol monophosphate 1-phosphatase activity
J172_02553	COG0513	Belongs to the DEAD box helicase family
J172_02554	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J172_02555	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
J172_02557	COG0625	glutathione transferase activity
J172_02559	COG4681	YaeQ
J172_02560	COG2081	HI0933 family
J172_02562	COG0501	Belongs to the peptidase M48B family
J172_02563	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J172_02564	COG1028	Short-chain dehydrogenase reductase Sdr
J172_02568	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J172_02569	COG0860	N-Acetylmuramoyl-L-alanine amidase
J172_02570	COG0802	atpase or kinase
J172_02571	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J172_02571	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J172_02572	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J172_02573	COG1570	exodeoxyribonuclease VII activity
J172_02575	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J172_02614	COG0835	chemotaxis
J172_02615	COG0840	transmembrane signaling receptor activity
J172_02616	COG2094	Belongs to the DNA glycosylase MPG family
J172_02617	COG1201	RNA secondary structure unwinding
J172_02620	COG2969	positive regulation of protein catabolic process
J172_02621	COG0625	glutathione transferase activity
J172_02622	COG2857	Cytochrome c1
J172_02623	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J172_02624	COG0723	plastoquinol--plastocyanin reductase activity
J172_02625	COG0741	lytic transglycosylase activity
J172_02628	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J172_02629	COG1702	phosphate starvation-inducible protein PhoH
J172_02631	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J172_02633	COG4535	Mg2 and Co2 transporter CorC
J172_02636	COG1012	belongs to the aldehyde dehydrogenase family
J172_02637	COG1177	transmembrane transport
J172_02638	COG1176	ABC-type spermidine putrescine transport system, permease component I
J172_02639	COG3842	ATPase activity
J172_02643	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
J172_02646	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J172_02647	COG0174	glutamine synthetase
J172_02648	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J172_02649	COG0745	RESPONSE REGULATOR receiver
J172_02649	COG3706	GGDEF domain
J172_02650	COG2703	oxygen carrier activity
J172_02651	COG0477	Major facilitator Superfamily
J172_02653	COG0243	molybdopterin cofactor binding
J172_02654	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
J172_02658	COG2733	membrane
J172_02659	COG5002	protein histidine kinase activity
J172_02659	COG0784	Response regulator, receiver
J172_02659	COG2205	protein histidine kinase activity
J172_02661	COG0477	Major facilitator Superfamily
J172_02662	COG2902	Dehydrogenase
J172_02664	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J172_02665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J172_02666	COG1609	Transcriptional regulator
J172_02667	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J172_02667	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J172_02668	COG1105	Belongs to the carbohydrate kinase PfkB family
J172_02669	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J172_02669	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J172_02677	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J172_02679	COG1862	Preprotein translocase
J172_02680	COG0343	queuine tRNA-ribosyltransferase activity
J172_02681	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
J172_02689	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
J172_02690	COG3291	Pkd domain containing protein
J172_02691	COG0405	Gamma-glutamyltransferase
J172_02692	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J172_02695	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J172_02696	COG0742	ribosomal rna small subunit methyltransferase
J172_02697	COG0326	Molecular chaperone. Has ATPase activity
J172_02713	COG0531	amino acid
J172_02716	COG0006	proline dipeptidase activity
J172_02718	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J172_02721	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J172_02722	COG3938	Belongs to the proline racemase family
J172_02724	COG0552	protein localization to endoplasmic reticulum
J172_02725	COG1194	a g-specific adenine glycosylase
J172_02726	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
J172_02727	COG0784	Response regulator, receiver
J172_02727	COG4191	Histidine kinase
J172_02730	COG0322	excinuclease ABC activity
J172_02733	COG3040	lipid binding
J172_02735	COG1960	acyl-CoA dehydrogenase activity
J172_02737	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J172_02741	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J172_02742	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J172_02743	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J172_02750	COG0438	transferase activity, transferring glycosyl groups
J172_02751	COG0438	transferase activity, transferring glycosyl groups
J172_02760	COG0776	regulation of translation
J172_02761	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J172_02761	COG0072	phenylalanine-tRNA ligase activity
J172_02762	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J172_02763	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J172_02764	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J172_02766	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J172_02767	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J172_02772	COG1082	Xylose isomerase domain protein TIM barrel
J172_02776	COG0366	Alpha amylase catalytic
J172_02778	COG2963	transposase activity
J172_02779	COG2801	Transposase and inactivated derivatives
J172_02792	COG2948	multi-organism process
J172_02796	COG3505	Type IV secretory pathway VirD4
J172_02799	COG0556	nucleotide-excision repair
J172_02807	COG2963	transposase activity
J172_02817	COG4695	Portal protein
J172_02826	COG3179	chitinase
J172_02837	COG2963	transposase activity
J172_02842	COG3275	phosphorelay sensor kinase activity
J172_02843	COG1611	Belongs to the LOG family
J172_02845	COG2095	MarC family integral membrane protein
J172_02847	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J172_02848	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J172_02854	COG1185	polyribonucleotide nucleotidyltransferase activity
J172_02855	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J172_02856	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J172_02857	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J172_02858	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J172_02859	COG0195	Participates in both transcription termination and antitermination
J172_02860	COG0779	Required for maturation of 30S ribosomal subunits
J172_02862	COG1007	ATP synthesis coupled electron transport
J172_02865	COG0713	ATP synthesis coupled electron transport
J172_02867	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J172_02868	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
J172_02870	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J172_02871	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
J172_02872	COG0649	NAD binding
J172_02873	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J172_02874	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J172_02875	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J172_02878	COG0149	triose-phosphate isomerase activity
J172_02879	COG0300	oxidoreductase activity
J172_02885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J172_02886	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
J172_02887	COG0159	tryptophan synthase activity
J172_02889	COG0133	tryptophan synthase activity
J172_02891	COG0135	phosphoribosylanthranilate isomerase activity
J172_02892	COG0101	tRNA pseudouridine synthase activity
J172_02896	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J172_02897	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J172_02898	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J172_02899	COG2890	protein-(glutamine-N5) methyltransferase activity
J172_02901	COG0688	phosphatidylethanolamine metabolic process
J172_02903	COG0433	COG0433 Predicted ATPase
J172_02904	COG0494	nUDIX hydrolase
J172_02907	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J172_02908	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J172_02913	COG0717	Belongs to the dCTP deaminase family
J172_02914	COG0489	protein tyrosine kinase activity
J172_02918	COG3590	peptidase
J172_02919	COG3590	peptidase
J172_02923	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J172_02924	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J172_02925	COG2311	Membrane
J172_02926	COG1047	Peptidyl-prolyl cis-trans
J172_02927	COG0791	NLP P60 protein
J172_02928	COG0791	NLP P60 protein
J172_02930	COG4106	trans-aconitate 2-methyltransferase activity
J172_02931	COG1301	dicarboxylic acid transport
J172_02932	COG1785	Belongs to the alkaline phosphatase family
J172_02933	COG0037	tRNA processing
J172_02934	COG1722	exodeoxyribonuclease VII activity
J172_02935	COG0142	geranyltranstransferase activity
J172_02936	COG4104	PAAR repeat-containing protein
J172_02938	COG0312	modulator of DNA gyrase
J172_02939	COG3028	Belongs to the UPF0307 family
J172_02940	COG0312	modulator of DNA gyrase
J172_02942	COG3164	Protein of unknown function
J172_02943	COG1530	ribonuclease E activity
J172_02944	COG0424	maF-like protein
J172_02945	COG2968	Membrane
J172_02948	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J172_02951	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J172_02954	COG0495	leucyl-tRNA aminoacylation
J172_02956	COG3118	belongs to the thioredoxin family
J172_02961	COG2155	Conserved Protein
J172_02962	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J172_02969	COG1132	(ABC) transporter
J172_02975	COG1538	Outer membrane efflux protein
J172_02976	COG0745	RESPONSE REGULATOR receiver
J172_02977	COG5002	protein histidine kinase activity
J172_02977	COG5000	phosphorelay sensor kinase activity
J172_02978	COG0475	glutathione-regulated potassium exporter activity
J172_02979	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J172_02980	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J172_02983	COG3706	GGDEF domain
J172_02983	COG0745	RESPONSE REGULATOR receiver
J172_02984	COG1187	pseudouridine synthase activity
J172_02985	COG5002	protein histidine kinase activity
J172_02985	COG5001	Diguanylate cyclase
J172_03009	COG0667	Aldo Keto reductase
J172_03010	COG2814	Major facilitator Superfamily
J172_03011	COG0583	DNA-binding transcription factor activity
J172_03013	COG2207	Transcriptional regulator
J172_03015	COG1309	transcriptional regulator
J172_03016	COG1538	Outer membrane efflux protein
J172_03020	COG0735	belongs to the Fur family
J172_03021	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J172_03026	COG4452	Inner membrane protein CreD
J172_03028	COG2205	protein histidine kinase activity
J172_03029	COG0745	RESPONSE REGULATOR receiver
J172_03030	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
J172_03032	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J172_03039	COG2198	Histidine kinase
J172_03039	COG0643	Histidine kinase
J172_03040	COG0840	transmembrane signaling receptor activity
J172_03041	COG0835	chemotaxis
J172_03042	COG2202	Pas domain
J172_03042	COG2199	diguanylate cyclase activity
J172_03042	COG2200	EAL domain
J172_03043	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J172_03044	COG2201	protein-glutamate methylesterase activity
J172_03045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J172_03046	COG3590	peptidase
J172_03048	COG0588	phosphoglycerate mutase activity
J172_03049	COG1515	deoxyribonuclease V activity
J172_03051	COG1741	Belongs to the pirin family
J172_03054	COG1741	Belongs to the pirin family
J172_03055	COG1966	Carbon starvation protein
J172_03056	COG2879	small protein
J172_03067	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
J172_03068	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J172_03069	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J172_03070	COG2080	2 iron, 2 sulfur cluster binding
J172_03072	COG4251	negative regulation of phosphorylation
J172_03072	COG3706	GGDEF domain
J172_03072	COG2203	Gaf domain
J172_03072	COG5001	Diguanylate cyclase
J172_03081	COG0629	single-stranded DNA binding
J172_03082	COG0142	geranyltranstransferase activity
J172_03084	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J172_03087	COG0527	aspartate kinase activity
J172_03088	COG0384	phenazine biosynthesis protein PhzF
J172_03089	COG0384	phenazine biosynthesis protein PhzF
J172_03091	COG1764	response to oxidative stress
J172_03092	COG0540	Belongs to the ATCase OTCase family
J172_03093	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J172_03094	COG1678	Uncharacterized ACR, COG1678
J172_03095	COG0519	Catalyzes the synthesis of GMP from XMP
J172_03098	COG5297	Belongs to the glycosyl hydrolase family 6
J172_03101	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J172_03104	COG0739	heme binding
J172_03108	COG0693	protein deglycase activity
J172_03110	COG1959	2 iron, 2 sulfur cluster binding
J172_03111	COG0719	Fe-S assembly protein
J172_03112	COG0396	ATPase activity
J172_03113	COG0719	Fe-S assembly protein
J172_03114	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J172_03117	COG4774	siderophore transport
J172_03118	COG3128	pkhd-type hydroxylase
J172_03123	COG1477	protein flavinylation
J172_03124	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J172_03127	COG1555	photosystem II stabilization
J172_03128	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J172_03130	COG3178	'Phosphotransferase
J172_03131	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J172_03133	COG0628	permease
J172_03135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J172_03137	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J172_03141	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J172_03142	COG0271	Belongs to the BolA IbaG family
J172_03144	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
J172_03146	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
J172_03147	COG1137	ATPase activity
J172_03150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J172_03151	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
J172_03152	COG1660	Displays ATPase and GTPase activities
J172_03154	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J172_03155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J172_03156	COG2239	Acts as a magnesium transporter
J172_03158	COG1294	oxidase, subunit
J172_03159	COG1271	oxidase subunit
J172_03161	COG1113	amino acid transport
J172_03164	COG2197	response regulator
J172_03165	COG0531	amino acid
J172_03170	COG1234	tRNA 3'-trailer cleavage
J172_03177	COG2814	Major facilitator Superfamily
J172_03179	COG0754	glutathionylspermidine amidase activity
J172_03184	COG1842	Phage shock protein A
J172_03186	COG0259	pyridoxamine-phosphate oxidase activity
J172_03187	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J172_03188	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J172_03190	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J172_03204	COG2814	Major facilitator Superfamily
J172_03208	COG2205	protein histidine kinase activity
J172_03208	COG2198	Histidine kinase
J172_03208	COG0784	Response regulator, receiver
J172_03209	COG2353	YceI-like domain
J172_03213	COG1760	l-serine dehydratase
J172_03215	COG0527	aspartate kinase activity
J172_03215	COG0460	homoserine dehydrogenase
J172_03216	COG0626	cystathionine gamma-synthase activity
J172_03217	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J172_03219	COG0739	heme binding
J172_03220	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J172_03221	COG1272	protein, Hemolysin III
J172_03222	COG2982	Protein involved in outer membrane biogenesis
J172_03223	COG0517	IMP dehydrogenase activity
J172_03223	COG0516	GMP reductase activity
J172_03224	COG0463	Glycosyl transferase, family 2
J172_03225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J172_03226	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
J172_03228	COG4771	TonB-dependent receptor
J172_03230	COG1309	transcriptional regulator
J172_03231	COG2267	carboxylic ester hydrolase activity
J172_03232	COG1960	acyl-CoA dehydrogenase activity
J172_03237	COG0509	glycine decarboxylation via glycine cleavage system
J172_03238	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J172_03240	COG0330	HflC and HflK could
J172_03241	COG1742	UPF0060 membrane protein
J172_03242	COG3956	TIGRFAM MazG family protein
J172_03244	COG0494	nUDIX hydrolase
J172_03246	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J172_03247	COG0837	glucose binding
J172_03250	COG1388	LysM domain
J172_03250	COG3858	chitin binding
J172_03251	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J172_03253	COG1472	Belongs to the glycosyl hydrolase 3 family
J172_03256	COG0531	amino acid
J172_03258	COG1486	melibiose metabolic process
J172_03260	COG3537	Alpha-1,2-mannosidase
J172_03267	COG3142	Participates in the control of copper homeostasis
J172_03268	COG1446	asparaginase
J172_03273	COG0840	transmembrane signaling receptor activity
J172_03277	COG0189	ligase activity
J172_03279	COG1397	ADP-ribosylglycohydrolase
J172_03281	COG1199	ATP-dependent helicase activity
J172_03283	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J172_03284	COG1215	transferase activity, transferring glycosyl groups
J172_03286	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J172_03287	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
J172_03288	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
J172_03289	COG0535	radical SAM domain protein
J172_03290	COG0535	radical SAM domain protein
J172_03293	COG0837	glucose binding
J172_03295	COG1643	Atp-dependent helicase
J172_03296	COG0783	Belongs to the Dps family
J172_03297	COG0514	ATP-dependent DNA helicase (RecQ)
J172_03304	COG0840	transmembrane signaling receptor activity
J172_03308	COG3920	Histidine kinase
J172_03309	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
J172_03311	COG0602	queuosine metabolic process
J172_03313	COG2885	chlorophyll binding
J172_03314	COG0823	Involved in the tonB-independent uptake of proteins
J172_03316	COG0848	biopolymer transport protein
J172_03318	COG0824	Thioesterase
J172_03319	COG2255	four-way junction helicase activity
J172_03321	COG3158	transport of potassium into the cell
J172_03322	COG0632	four-way junction helicase activity
J172_03323	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J172_03324	COG0217	transcriptional regulatory protein
J172_03327	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J172_03330	COG0477	Major facilitator Superfamily
J172_03338	COG0488	(ABC) transporter
J172_03344	COG4651	solute:proton antiporter activity
J172_03344	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J172_03349	COG4772	TonB-dependent receptor
J172_03351	COG4264	IucA IucC family
J172_03354	COG0019	diaminopimelate decarboxylase activity
J172_03359	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
J172_03361	COG1492	cobalamin metabolic process
J172_03363	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
J172_03367	COG4206	TonB-dependent receptor
J172_03369	COG0542	response to heat
J172_03370	COG1116	anion transmembrane transporter activity
J172_03371	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J172_03372	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J172_03373	COG0667	Aldo Keto reductase
J172_03375	COG4771	TonB-dependent receptor
J172_03376	COG2827	Endonuclease containing a URI domain
J172_03384	COG1877	trehalose-phosphatase activity
J172_03385	COG3387	PFAM Glycoside hydrolase 15-related
J172_03388	COG0840	transmembrane signaling receptor activity
J172_03389	COG3011	Protein conserved in bacteria
J172_03392	COG0564	pseudouridine synthase activity
J172_03393	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J172_03395	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
J172_03395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J172_03397	COG2963	transposase activity
J172_03401	COG2951	lytic endotransglycosylase activity
J172_03402	COG4644	lycopene metabolic process
J172_03406	COG2369	cell adhesion
J172_03411	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
J172_03412	COG0045	succinate-CoA ligase (ADP-forming) activity
J172_03416	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J172_03422	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
J172_03423	COG0237	dephospho-CoA kinase activity
J172_03426	COG2963	transposase activity
J172_03428	COG5002	protein histidine kinase activity
J172_03429	COG0745	RESPONSE REGULATOR receiver
J172_03431	COG0189	ligase activity
J172_03445	COG2003	Belongs to the UPF0758 family
J172_03450	COG0784	Response regulator, receiver
J172_03450	COG4191	Histidine kinase
J172_03451	COG4191	Histidine kinase
J172_03451	COG0784	Response regulator, receiver
J172_03470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J172_03476	COG2022	thiamine diphosphate biosynthetic process
J172_03477	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J172_03478	COG3273	potassium ion transport
J172_03478	COG0471	metal ion transport
J172_03482	COG1970	mechanosensitive ion channel activity
J172_03486	COG3250	beta-galactosidase activity
J172_03487	COG4948	Mandelate Racemase Muconate Lactonizing
J172_03490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J172_03492	COG0308	aminopeptidase N
J172_03495	COG2963	transposase activity
J172_03501	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J172_03503	COG2895	sulfate adenylyltransferase (ATP) activity
J172_03503	COG0529	Catalyzes the synthesis of activated sulfate
J172_03504	COG0175	sulfate reduction
J172_03505	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J172_03506	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J172_03507	COG0175	sulfate reduction
J172_03514	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J172_03514	COG1648	precorrin-2 dehydrogenase activity
J172_03517	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
J172_03518	COG3588	fructose-bisphosphate aldolase
J172_03519	COG0469	pyruvate kinase activity
J172_03521	COG0126	phosphoglycerate kinase activity
J172_03526	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J172_03528	COG3047	cAMP biosynthetic process
J172_03529	COG3047	cAMP biosynthetic process
J172_03531	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J172_03531	COG3453	Protein conserved in bacteria
J172_03532	COG0725	ABC transporter, periplasmic molybdate-binding protein
J172_03533	COG4149	molybdate abc transporter
J172_03534	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
J172_03541	COG1376	ErfK ybiS ycfS ynhG family protein
J172_03542	COG0739	heme binding
J172_03544	COG4773	Receptor
J172_03545	COG0596	Alpha beta hydrolase
J172_03546	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
J172_03547	COG1301	dicarboxylic acid transport
J172_03549	COG2304	oxidoreductase activity
J172_03553	COG0714	Associated with various cellular activities
J172_03560	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J172_03564	COG0254	rRNA binding
J172_03566	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J172_03568	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J172_03569	COG1758	RNA polymerase activity
J172_03570	COG0194	GDP metabolic process
J172_03571	COG1561	YicC-like family, N-terminal region
J172_03572	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J172_03574	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J172_03575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J172_03579	COG0006	proline dipeptidase activity
J172_03581	COG0006	proline dipeptidase activity
J172_03582	COG3079	Belongs to the UPF0149 family
J172_03586	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J172_03588	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
J172_03590	COG2912	Transglutaminase-like superfamily
J172_03591	COG1773	rubredoxin
J172_03592	COG0352	thiamine-phosphate diphosphorylase activity
J172_03595	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J172_03598	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J172_03604	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J172_03605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J172_03606	COG1028	Short-chain dehydrogenase reductase Sdr
J172_03608	COG0671	phosphoesterase, PA-phosphatase related
J172_03609	COG3781	membrane
J172_03611	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J172_03612	COG0563	adenylate kinase activity
J172_03615	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
J172_03617	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
J172_03621	COG3710	Transcriptional regulator
J172_03622	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
J172_03625	COG0840	transmembrane signaling receptor activity
J172_03626	COG0405	Gamma-glutamyltransferase
J172_03627	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J172_03631	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J172_03632	COG0473	3-isopropylmalate dehydrogenase activity
J172_03633	COG0066	3-isopropylmalate dehydratase activity
J172_03634	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J172_03638	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J172_03639	COG1538	Outer membrane efflux protein
J172_03640	COG1519	Transferase
J172_03641	COG1560	Kdo2-lipid A biosynthetic process
J172_03646	COG0280	phosphate acetyltransferase
J172_03646	COG0281	malic enzyme
J172_03647	COG1301	dicarboxylic acid transport
J172_03652	COG0583	DNA-binding transcription factor activity
J172_03653	COG0667	Aldo Keto reductase
J172_03657	COG2197	response regulator
J172_03658	COG1840	ABC-type Fe3 transport system, periplasmic component
J172_03659	COG0642	Histidine kinase
J172_03662	COG2851	Citrate transporter
J172_03664	COG1028	Short-chain dehydrogenase reductase Sdr
J172_03665	COG1609	Transcriptional regulator
J172_03666	COG2211	Major facilitator Superfamily
J172_03671	COG1162	GTPase activity
J172_03675	COG4773	Receptor
J172_03676	COG0726	polysaccharide deacetylase
J172_03677	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J172_03680	COG2963	transposase activity
J172_03681	COG2801	Transposase and inactivated derivatives
J172_03685	COG1307	EDD domain protein, DegV family
J172_03686	COG0242	peptide deformylase activity
J172_03690	COG0457	Tetratricopeptide repeat
J172_03691	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
J172_03692	COG1215	transferase activity, transferring glycosyl groups
J172_03693	COG1215	transferase activity, transferring glycosyl groups
J172_03697	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
J172_03707	COG2188	Transcriptional regulator
J172_03709	COG1450	Type ii and iii secretion system protein
J172_03712	COG3166	PFAM Fimbrial assembly family protein
J172_03713	COG3156	type II secretion system protein K
J172_03714	COG4795	General secretion pathway protein
J172_03715	COG2165	general secretion pathway protein
J172_03716	COG4970	Tfp pilus assembly protein FimT
J172_03717	COG2165	general secretion pathway protein
J172_03718	COG1459	type II secretion system
J172_03719	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J172_03720	COG1404	Belongs to the peptidase S8 family
J172_03721	COG5295	Hep Hag repeat protein
J172_03722	COG1404	Belongs to the peptidase S8 family
J172_03723	COG5295	Hep Hag repeat protein
J172_03724	COG0047	phosphoribosylformylglycinamidine synthase activity
J172_03724	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J172_03725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J172_03726	COG4974	Belongs to the 'phage' integrase family
J172_03729	COG0795	lipopolysaccharide-transporting ATPase activity
J172_03731	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J172_03734	COG0525	valine-tRNA ligase activity
J172_03740	COG1183	phosphatidylcholine synthase activity
J172_03742	COG0442	prolyl-tRNA aminoacylation
J172_03745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J172_03746	COG1127	ABC transporter
J172_03747	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J172_03747	COG3218	ABC-type transport auxiliary lipoprotein component
J172_03754	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J172_03755	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
J172_03755	COG0662	Cupin 2, conserved barrel domain protein
J172_03761	COG2086	electron transfer activity
J172_03764	COG0546	phosphoglycolate phosphatase activity
J172_03764	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J172_03765	COG0277	FAD linked oxidase domain protein
J172_03768	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J172_03774	COG1216	Glycosyl transferase, family 2
J172_03774	COG0438	transferase activity, transferring glycosyl groups
J172_03778	COG0626	cystathionine gamma-synthase activity
J172_03784	COG0625	glutathione transferase activity
J172_03786	COG0513	Belongs to the DEAD box helicase family
J172_03789	COG4206	TonB-dependent receptor
J172_03790	COG0720	synthase
J172_03792	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
J172_03793	COG1956	GAF domain-containing protein
J172_03795	COG2819	hydrolase of the alpha beta superfamily
J172_03798	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J172_03799	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J172_03802	COG0339	signal peptide processing
J172_03805	COG2132	Multicopper oxidase
J172_03813	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J172_03814	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J172_03815	COG1136	(ABC) transporter
J172_03815	COG4591	ABC-type transport system involved in lipoprotein release permease component
J172_03816	COG0577	efflux transmembrane transporter activity
J172_03816	COG1136	(ABC) transporter
J172_03817	COG0577	efflux transmembrane transporter activity
J172_03819	COG2204	response regulator
J172_03820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J172_03823	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J172_03824	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J172_03825	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J172_03826	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J172_03827	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J172_03828	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J172_03830	COG0356	it plays a direct role in the translocation of protons across the membrane
J172_03834	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J172_03836	COG0508	dehydrogenase complex catalyzes the overall conversion of
J172_03843	COG2011	ABC-type metal ion transport system permease component
J172_03844	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J172_03845	COG0697	spore germination
J172_03846	COG1666	GTP binding
J172_03848	COG2198	Histidine kinase
J172_03848	COG5002	protein histidine kinase activity
J172_03848	COG0784	Response regulator, receiver
J172_03852	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J172_03853	COG1187	pseudouridine synthase activity
J172_03854	COG2813	Specifically methylates the guanine in position
J172_03858	COG2202	Pas domain
J172_03858	COG2205	protein histidine kinase activity
J172_03862	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J172_03863	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J172_03864	COG1522	sequence-specific DNA binding
J172_03874	COG0842	Transport permease protein
J172_03875	COG1131	(ABC) transporter
J172_03876	COG0025	NhaP-type Na H and K H
J172_03877	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
J172_03878	COG1573	uracil-dna glycosylase
J172_03880	COG3384	dioxygenase
J172_03882	COG0583	DNA-binding transcription factor activity
J172_03884	COG0667	Aldo Keto reductase
J172_03886	COG3590	peptidase
J172_03890	COG0531	amino acid
J172_03893	COG2972	Histidine kinase
J172_03896	COG3685	Protein conserved in bacteria
J172_03897	COG3546	catalase activity
J172_03905	COG1271	oxidase subunit
J172_03906	COG1294	oxidase, subunit
J172_03909	COG1028	Short-chain dehydrogenase reductase Sdr
J172_03910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J172_03914	COG1132	(ABC) transporter
J172_03917	COG1063	alcohol dehydrogenase
J172_03932	COG0251	oxidation-reduction process
J172_03938	COG0840	transmembrane signaling receptor activity
J172_03942	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J172_03951	COG0024	Methionine aminopeptidase
J172_03956	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J172_03957	COG1490	D-aminoacyl-tRNA deacylase activity
J172_03958	COG1560	Kdo2-lipid A biosynthetic process
J172_03967	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J172_03967	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J172_03968	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J172_03969	COG0242	peptide deformylase activity
J172_03970	COG1652	LysM domain
J172_03971	COG0758	DNA mediated transformation
J172_03972	COG2922	Belongs to the Smg family
J172_03975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J172_03975	COG1754	DNA topoisomerase type I activity
J172_03976	COG0009	L-threonylcarbamoyladenylate synthase
J172_03979	COG1028	Short-chain dehydrogenase reductase Sdr
J172_03981	COG0616	signal peptide processing
J172_03982	COG0534	Mate efflux family protein
J172_03986	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J172_03987	COG0625	glutathione transferase activity
J172_03990	COG1252	NADH dehydrogenase
J172_03991	COG2860	membrane
J172_03992	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J172_03993	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J172_03994	COG2201	protein-glutamate methylesterase activity
J172_03995	COG2177	Part of the ABC transporter FtsEX involved in
J172_03996	COG2884	Cell division ATP-binding protein ftsE
J172_03997	COG0513	Belongs to the DEAD box helicase family
J172_03998	COG3118	belongs to the thioredoxin family
J172_03999	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J172_04000	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
J172_04001	COG0583	DNA-binding transcription factor activity
J172_04011	COG1518	maintenance of DNA repeat elements
J172_04012	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
J172_04014	COG1652	LysM domain
J172_04015	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J172_04015	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J172_04016	COG1473	amidohydrolase
J172_04017	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J172_04018	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J172_04020	COG5383	Protein conserved in bacteria
J172_04028	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
J172_04029	COG3023	N-Acetylmuramoyl-L-alanine amidase
J172_04031	COG4948	Mandelate Racemase Muconate Lactonizing
J172_04033	COG0531	amino acid
J172_04036	COG4682	membrane
J172_04037	COG2133	pyrroloquinoline quinone binding
J172_04039	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J172_04040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J172_04041	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J172_04042	COG1610	YqeY-like protein
J172_04043	COG1295	ribonuclease BN
J172_04044	COG0358	DNA primase activity
J172_04047	COG0109	protoheme IX farnesyltransferase activity
J172_04053	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
J172_04056	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J172_04066	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J172_04067	COG0739	heme binding
J172_04068	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
J172_04070	COG2223	nitrite transmembrane transporter activity
J172_04071	COG0708	Exodeoxyribonuclease III
J172_04072	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J172_04074	COG1192	Involved in chromosome partitioning
J172_04075	COG1475	DNA binding
J172_04078	COG0463	Glycosyl transferase, family 2
J172_04082	COG0756	dUTP diphosphatase activity
J172_04083	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J172_04084	COG2003	Belongs to the UPF0758 family
J172_04085	COG0018	arginyl-trna synthetase
J172_04088	COG4221	oxidoreductase activity
J172_04089	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J172_04089	COG2755	lipolytic protein G-D-S-L family
J172_04091	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J172_04092	COG1166	arginine decarboxylase activity
J172_04093	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
J172_04100	COG0606	chelatase, subunit chli
J172_04114	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J172_04123	COG0606	chelatase, subunit chli
J172_04126	COG4943	cyclic-guanylate-specific phosphodiesterase activity
J172_04135	COG1690	Belongs to the RtcB family
J172_04143	COG1090	epimerase
J172_04144	COG0745	RESPONSE REGULATOR receiver
J172_04145	COG0642	Histidine kinase
J172_04149	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J172_04154	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J172_04155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J172_04158	COG0753	catalase activity
J172_04161	COG2197	response regulator
J172_04162	COG4585	Histidine kinase
J172_04163	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J172_04164	COG1136	(ABC) transporter
J172_04168	COG2962	Rard protein
J172_04170	COG0697	spore germination
J172_04173	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J172_04174	COG0180	Tryptophanyl-tRNA synthetase
J172_04175	COG3237	CsbD-like
J172_04183	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J172_04186	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
J172_04187	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J172_04187	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J172_04192	COG2205	protein histidine kinase activity
J172_04193	COG0745	RESPONSE REGULATOR receiver
J172_04195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J172_04199	COG1199	ATP-dependent helicase activity
J172_04202	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J172_04213	COG0625	glutathione transferase activity
J172_04220	COG4555	ABC transporter
J172_04222	COG1476	TRANSCRIPTIONal
J172_04231	COG0543	2 iron, 2 sulfur cluster binding
J172_04231	COG0633	Ferredoxin
J172_04232	COG1131	(ABC) transporter
J172_04233	COG0842	Transport permease protein
J172_04236	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
J172_04242	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J172_04243	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J172_04245	COG1042	CoA-binding domain protein
J172_04245	COG0045	succinate-CoA ligase (ADP-forming) activity
J172_04245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J172_04246	COG2239	Acts as a magnesium transporter
J172_04247	COG3338	carbonate dehydratase activity
J172_04249	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J172_04250	COG3387	PFAM Glycoside hydrolase 15-related
J172_04253	COG3100	YcgL domain-containing protein
J172_04254	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J172_04256	COG0463	Glycosyl transferase, family 2
J172_04259	COG1028	Short-chain dehydrogenase reductase Sdr
J172_04267	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J172_04270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J172_04275	COG1506	peptidase
J172_04275	COG4946	Tricorn protease homolog
J172_04275	COG0823	Involved in the tonB-independent uptake of proteins
J172_04278	COG0408	coproporphyrinogen oxidase activity
J172_04285	COG0515	serine threonine protein kinase
J172_04285	COG2815	serine threonine protein kinase
J172_04286	COG0631	protein serine/threonine phosphatase activity
J172_04293	COG3501	Rhs element vgr protein
J172_04319	COG0210	DNA helicase
J172_04321	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J172_04322	COG0583	DNA-binding transcription factor activity
J172_04323	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J172_04325	COG2159	amidohydrolase
J172_04326	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J172_04327	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J172_04329	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J172_04333	COG0357	Ribosomal RNA small subunit methyltransferase G
J172_04334	COG3540	Alkaline phosphatase
J172_04337	COG2091	lysine biosynthetic process via aminoadipic acid
J172_04340	COG0708	Exodeoxyribonuclease III
J172_04342	COG1846	Transcriptional regulator
J172_04342	COG1940	carbohydrate kinase activity
J172_04344	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J172_04346	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J172_04347	COG3162	membrane
J172_04349	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J172_04355	COG3507	Belongs to the glycosyl hydrolase 43 family
J172_04358	COG1028	Short-chain dehydrogenase reductase Sdr
J172_04359	COG0179	Fumarylacetoacetate (FAA) hydrolase
J172_04360	COG4948	Mandelate Racemase Muconate Lactonizing
J172_04362	COG3254	rhamnose metabolic process
J172_04363	COG0738	Major facilitator superfamily
J172_04364	COG1414	Transcriptional regulator
J172_04365	COG1971	Probably functions as a manganese efflux pump
J172_04366	COG2205	protein histidine kinase activity
J172_04368	COG3459	Glycosyltransferase 36 associated
J172_04369	COG2211	Major facilitator Superfamily
J172_04370	COG3265	gluconokinase activity
J172_04371	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J172_04375	COG2911	Protein conserved in bacteria
J172_04376	COG0729	surface antigen
J172_04379	COG2963	transposase activity
J172_04384	COG0752	glycyl-tRNA synthetase alpha subunit
J172_04385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J172_04387	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J172_04387	COG0519	Catalyzes the synthesis of GMP from XMP
J172_04389	COG0805	protein transport
J172_04390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J172_04391	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J172_04393	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J172_04396	COG2974	May be involved in recombination
J172_04397	COG0037	tRNA processing
J172_04398	COG2115	Belongs to the xylose isomerase family
J172_04400	COG3661	Belongs to the glycosyl hydrolase 67 family
J172_04402	COG4948	Mandelate Racemase Muconate Lactonizing
J172_04404	COG1472	Belongs to the glycosyl hydrolase 3 family
J172_04405	COG0246	Mannitol dehydrogenase
J172_04413	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J172_04414	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J172_04419	COG3386	PFAM SMP-30 Gluconolaconase
J172_04421	COG3250	beta-galactosidase activity
J172_04422	COG1904	glucuronate isomerase
J172_04423	COG3693	PFAM glycoside hydrolase, family 10
J172_04425	COG3693	PFAM glycoside hydrolase, family 10
J172_04428	COG2211	Major facilitator Superfamily
J172_04440	COG2937	Belongs to the GPAT DAPAT family
J172_04446	COG0284	orotidine-5'-phosphate decarboxylase activity
J172_04447	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
J172_04449	COG3132	Protein of unknown function, DUF480
J172_04452	COG0210	DNA helicase
J172_04453	COG1435	thymidine kinase activity
J172_04455	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
J172_04457	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J172_04464	COG3135	benzoate transporter
J172_04468	COG0676	glucose-6-phosphate 1-epimerase activity
J172_04470	COG3012	SEC-C Motif Domain Protein
J172_04471	COG0730	response to heat
J172_04475	COG0302	gtp cyclohydrolase
J172_04478	COG1566	PFAM secretion protein HlyD family protein
J172_04480	COG1289	transmembrane transporter activity
J172_04481	COG0477	Major facilitator Superfamily
J172_04483	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J172_04487	COG4691	Plasmid stability protein
J172_04488	COG1487	ribonuclease activity
J172_04493	COG0564	pseudouridine synthase activity
J172_04495	COG2963	transposase activity
J172_04499	COG0439	Biotin carboxylase
J172_04510	COG1074	ATP-dependent DNA helicase activity
J172_04511	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
J172_04513	COG1127	ABC transporter
J172_04514	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J172_04515	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J172_04518	COG2853	Lipoprotein
J172_04520	COG0386	Belongs to the glutathione peroxidase family
J172_04522	COG1322	Protein conserved in bacteria
J172_04523	COG0604	alcohol dehydrogenase
J172_04524	COG0583	DNA-binding transcription factor activity
J172_04526	COG0625	glutathione transferase activity
J172_04528	COG0531	amino acid
J172_04529	COG3537	Alpha-1,2-mannosidase
J172_04531	COG3706	GGDEF domain
J172_04532	COG3835	regulator
J172_04533	COG1929	Belongs to the glycerate kinase type-1 family
J172_04534	COG2271	Major facilitator Superfamily
J172_04537	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J172_04539	COG0861	Integral membrane protein TerC family
J172_04541	COG0584	glycerophosphoryl diester phosphodiesterase
J172_04544	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
J172_04545	COG0726	polysaccharide deacetylase
J172_04546	COG0706	membrane insertase activity
J172_04547	COG0594	ribonuclease P activity
J172_04548	COG0230	Belongs to the bacterial ribosomal protein bL34 family