locus-tag	class	description
XAC0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XAC0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XAC0004	COG0187	DNA topoisomerase II activity
XAC0006	COG0501	Belongs to the peptidase M48B family
XAC0012	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XAC0014	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAC0023	COG0793	Belongs to the peptidase S41A family
XAC0024	COG4942	peptidase
XAC0026	COG2234	aminopeptidase activity
XAC0028	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC0029	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC0030	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC0031	COG1064	alcohol dehydrogenase
XAC0032	COG0493	'glutamate synthase
XAC0033	COG0069	glutamate synthase activity
XAC0033	COG0067	glutamate synthase
XAC0033	COG0070	glutamate synthase
XAC0037	COG2366	antibiotic biosynthetic process
XAC0043	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
XAC0046	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XAC0047	COG0297	glycogen (starch) synthase activity
XAC0047	COG0438	transferase activity, transferring glycosyl groups
XAC0051	COG0367	asparagine synthase
XAC0057	COG1132	(ABC) transporter
XAC0078	COG1205	dead DEAH box helicase
XAC0078	COG1111	helicase
XAC0079	COG1272	protein, Hemolysin III
XAC0082	COG0300	oxidoreductase activity
XAC0083	COG1028	Short-chain dehydrogenase reductase Sdr
XAC0088	COG2249	NAD(P)H dehydrogenase (quinone) activity
XAC0090	COG2963	transposase activity
XAC0091	COG2801	Transposase and inactivated derivatives
XAC0100	COG3237	CsbD-like
XAC0109	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XAC0110	COG0477	Major facilitator Superfamily
XAC0118	COG0714	Associated with various cellular activities
XAC0124	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XAC0126	COG4772	TonB-dependent receptor
XAC0128	COG0662	Cupin 2, conserved barrel domain protein
XAC0129	COG1012	belongs to the aldehyde dehydrogenase family
XAC0133	COG1304	FMN binding
XAC0135	COG4585	Histidine kinase
XAC0136	COG2197	response regulator
XAC0140	COG3710	Transcriptional regulator
XAC0141	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XAC0152	COG2963	transposase activity
XAC0154	COG0366	Alpha amylase catalytic
XAC0155	COG0366	Alpha amylase catalytic
XAC0156	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XAC0160	COG0657	acetylesterase activity
XAC0160	COG2755	lipolytic protein G-D-S-L family
XAC0162	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XAC0165	COG3507	Belongs to the glycosyl hydrolase 43 family
XAC0166	COG1609	Transcriptional regulator
XAC0168	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
XAC0169	COG1028	Short-chain dehydrogenase reductase Sdr
XAC0171	COG2755	lipolytic protein G-D-S-L family
XAC0174	COG3186	Phenylalanine-4-hydroxylase
XAC0175	COG1522	sequence-specific DNA binding
XAC0177	COG1752	Esterase of the alpha-beta hydrolase superfamily
XAC0179	COG1119	ATPase activity
XAC0182	COG1125	glycine betaine transport
XAC0185	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XAC0188	COG1396	sequence-specific DNA binding
XAC0192	COG0489	protein tyrosine kinase activity
XAC0193	COG2062	phosphohistidine phosphatase, SixA
XAC0195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAC0203	COG1968	undecaprenyl-diphosphatase activity
XAC0204	COG0174	glutamine synthetase
XAC0205	COG0347	Belongs to the P(II) protein family
XAC0206	COG0004	ammonium transporteR
XAC0207	COG3852	Histidine kinase
XAC0208	COG2204	response regulator
XAC0209	COG2032	superoxide dismutase activity
XAC0210	COG2032	superoxide dismutase activity
XAC0211	COG0346	lactoylglutathione lyase activity
XAC0213	COG0183	Belongs to the thiolase family
XAC0220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XAC0221	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XAC0222	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XAC0224	COG0028	Belongs to the TPP enzyme family
XAC0225	COG2205	protein histidine kinase activity
XAC0230	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XAC0233	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XAC0235	COG0596	Alpha beta hydrolase
XAC0237	COG0318	PFAM AMP-dependent synthetase and ligase
XAC0238	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XAC0240	COG1181	Belongs to the D-alanine--D-alanine ligase family
XAC0242	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XAC0244	COG0564	pseudouridine synthase activity
XAC0249	COG0339	signal peptide processing
XAC0254	COG0475	glutathione-regulated potassium exporter activity
XAC0255	COG0583	DNA-binding transcription factor activity
XAC0256	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XAC0257	COG2224	Isocitrate lyase
XAC0258	COG3706	GGDEF domain
XAC0264	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XAC0265	COG1960	acyl-CoA dehydrogenase activity
XAC0276	COG0523	cobalamin synthesis protein
XAC0278	COG0697	spore germination
XAC0280	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XAC0281	COG1846	Transcriptional regulator
XAC0282	COG1764	response to oxidative stress
XAC0287	COG2130	NADP-dependent
XAC0290	COG1187	pseudouridine synthase activity
XAC0293	COG1643	Atp-dependent helicase
XAC0294	COG4807	Protein conserved in bacteria
XAC0295	COG2351	hydroxyisourate hydrolase activity
XAC0296	COG2072	flavoprotein involved in K transport
XAC0300	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XAC0307	COG1957	nucleoside hydrolase
XAC0309	COG2252	PERMEase
XAC0313	COG0084	hydrolase, TatD family'
XAC0316	COG0583	DNA-binding transcription factor activity
XAC0317	COG2814	Major facilitator Superfamily
XAC0320	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XAC0321	COG1902	pentaerythritol trinitrate reductase activity
XAC0325	COG0745	RESPONSE REGULATOR receiver
XAC0326	COG2205	protein histidine kinase activity
XAC0327	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAC0329	COG1538	Outer membrane efflux protein
XAC0331	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XAC0332	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XAC0333	COG0583	DNA-binding transcription factor activity
XAC0339	COG0702	epimerase
XAC0340	COG1733	regulation of RNA biosynthetic process
XAC0343	COG2963	transposase activity
XAC0345	COG0129	dihydroxy-acid dehydratase activity
XAC0348	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XAC0358	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XAC0359	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XAC0364	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XAC0365	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XAC0367	COG3485	protocatechuate 3,4-dioxygenase
XAC0368	COG3485	protocatechuate 3,4-dioxygenase
XAC0370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XAC0371	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XAC0373	COG1414	Transcriptional regulator
XAC0377	COG0445	tRNA wobble uridine modification
XAC0385	COG2267	carboxylic ester hydrolase activity
XAC0387	COG0156	8-amino-7-oxononanoate synthase activity
XAC0388	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XAC0389	COG1040	competence protein
XAC0390	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XAC0406	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XAC0420	COG3264	Mechanosensitive ion channel
XAC0420	COG1511	domain protein
XAC0421	COG1368	sulfuric ester hydrolase activity
XAC0422	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XAC0423	COG2354	Protein conserved in bacteria
XAC0424	COG0745	RESPONSE REGULATOR receiver
XAC0424	COG3706	GGDEF domain
XAC0425	COG0297	glycogen (starch) synthase activity
XAC0426	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XAC0427	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XAC0432	COG0702	epimerase
XAC0433	COG1028	Short-chain dehydrogenase reductase Sdr
XAC0439	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XAC0440	COG1028	Short-chain dehydrogenase reductase Sdr
XAC0442	COG0513	Belongs to the DEAD box helicase family
XAC0446	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
XAC0448	COG3483	tryptophan 2,3-dioxygenase activity
XAC0449	COG3104	oligopeptide transport
XAC0453	COG2852	Protein conserved in bacteria
XAC0454	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
XAC0457	COG1320	monovalent cation:proton antiporter activity
XAC0458	COG2212	antiporter activity
XAC0460	COG0651	ATP synthesis coupled electron transport
XAC0461	COG1006	Multisubunit Na H antiporter MnhC subunit
XAC0462	COG2111	Na H antiporter
XAC0462	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XAC0466	COG3179	chitinase
XAC0470	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XAC0471	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XAC0474	COG0456	acetyltransferase
XAC0475	COG1597	lipid kinase activity
XAC0480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XAC0481	COG0134	indole-3-glycerol-phosphate synthase activity
XAC0483	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XAC0484	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XAC0486	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XAC0487	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XAC0488	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XAC0491	COG1051	belongs to the nudix hydrolase family
XAC0499	COG0316	Belongs to the HesB IscA family
XAC0504	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XAC0507	COG2814	Major facilitator Superfamily
XAC0508	COG0583	DNA-binding transcription factor activity
XAC0509	COG2814	Major facilitator Superfamily
XAC0510	COG1289	transmembrane transporter activity
XAC0511	COG0151	Belongs to the GarS family
XAC0513	COG0138	bifunctional purine biosynthesis protein purh
XAC0514	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XAC0515	COG2267	carboxylic ester hydrolase activity
XAC0516	COG2453	phosphatase
XAC0516	COG0671	phosphoesterase, PA-phosphatase related
XAC0521	COG4589	Belongs to the CDS family
XAC0522	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XAC0526	COG2264	protein methyltransferase activity
XAC0530	COG0439	Biotin carboxylase
XAC0532	COG0511	ligase activity, forming carbon-carbon bonds
XAC0533	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XAC0535	COG1324	tolerance protein
XAC0539	COG0300	oxidoreductase activity
XAC0540	COG2356	endonuclease I
XAC0541	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
XAC0542	COG0459	protein refolding
XAC0545	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XAC0548	COG3386	PFAM SMP-30 Gluconolaconase
XAC0550	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XAC0551	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XAC0554	COG0778	Nitroreductase
XAC0555	COG2353	YceI-like domain
XAC0561	COG3052	prosthetic group binding
XAC0565	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
XAC0566	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XAC0568	COG1802	Transcriptional regulator
XAC0579	COG2963	transposase activity
XAC0580	COG4221	oxidoreductase activity
XAC0583	COG4221	oxidoreductase activity
XAC0585	COG0435	Glutathione S-transferase
XAC0590	COG2409	Drug exporters of the RND superfamily
XAC0591	COG0823	Involved in the tonB-independent uptake of proteins
XAC0591	COG1506	peptidase
XAC0593	COG3706	GGDEF domain
XAC0597	COG0697	spore germination
XAC0600	COG1113	amino acid transport
XAC0602	COG0598	Magnesium transport protein CorA
XAC0604	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
XAC0610	COG5001	Diguanylate cyclase
XAC0611	COG0840	transmembrane signaling receptor activity
XAC0612	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC0612	COG5297	Belongs to the glycosyl hydrolase family 6
XAC0613	COG0659	secondary active sulfate transmembrane transporter activity
XAC0614	COG3706	GGDEF domain
XAC0618	COG2943	transferase activity, transferring hexosyl groups
XAC0620	COG3275	phosphorelay sensor kinase activity
XAC0622	COG0181	hydroxymethylbilane synthase activity
XAC0628	COG1505	serine-type exopeptidase activity
XAC0629	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XAC0632	COG2832	Protein of unknown function (DUF454)
XAC0634	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XAC0636	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XAC0637	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XAC0638	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XAC0643	COG2226	methyltransferase
XAC0644	COG5001	Diguanylate cyclase
XAC0644	COG3300	MHYT domain
XAC0645	COG0308	aminopeptidase N
XAC0654	COG3284	Transcriptional regulator
XAC0656	COG1077	Cell shape determining protein MreB Mrl
XAC0657	COG1792	Involved in formation and maintenance of cell shape
XAC0660	COG0772	Belongs to the SEDS family
XAC0662	COG2951	lytic endotransglycosylase activity
XAC0663	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XAC0664	COG1686	Belongs to the peptidase S11 family
XAC0666	COG2921	Belongs to the UPF0250 family
XAC0667	COG0321	lipoyl(octanoyl) transferase activity
XAC0668	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XAC0671	COG0583	DNA-binding transcription factor activity
XAC0673	COG1051	belongs to the nudix hydrolase family
XAC0673	COG1056	cytidyltransferase-related domain
XAC0680	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XAC0681	COG0673	inositol 2-dehydrogenase activity
XAC0682	COG2823	Periplasmic or secreted lipoprotein
XAC0683	COG4251	negative regulation of phosphorylation
XAC0684	COG0784	Response regulator, receiver
XAC0685	COG4191	Histidine kinase
XAC0686	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XAC0697	COG1459	type II secretion system
XAC0708	COG3250	beta-galactosidase activity
XAC0713	COG1609	Transcriptional regulator
XAC0714	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XAC0715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XAC0717	COG0617	tRNA 3'-terminal CCA addition
XAC0718	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XAC0719	COG1012	belongs to the aldehyde dehydrogenase family
XAC0720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XAC0722	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XAC0725	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XAC0726	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XAC0729	COG2205	protein histidine kinase activity
XAC0730	COG0745	RESPONSE REGULATOR receiver
XAC0735	COG3791	Glutathione-dependent formaldehyde-activating
XAC0737	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XAC0739	COG0697	spore germination
XAC0741	COG0488	(ABC) transporter
XAC0743	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XAC0744	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XAC0746	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XAC0746	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XAC0750	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XAC0751	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XAC0752	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XAC0756	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XAC0757	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XAC0758	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
XAC0759	COG2205	protein histidine kinase activity
XAC0760	COG0745	RESPONSE REGULATOR receiver
XAC0762	COG0277	FAD linked oxidase domain protein
XAC0763	COG1988	membrane-bound metal-dependent
XAC0764	COG0792	nuclease activity
XAC0771	COG2001	Belongs to the MraZ family
XAC0772	COG0275	rRNA processing
XAC0773	COG3116	cell division
XAC0775	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XAC0776	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XAC0777	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XAC0779	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XAC0780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XAC0781	COG1181	Belongs to the D-alanine--D-alanine ligase family
XAC0782	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XAC0785	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XAC0787	COG0739	heme binding
XAC0788	COG0653	protein targeting
XAC0789	COG0494	nUDIX hydrolase
XAC0791	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XAC0794	COG0604	alcohol dehydrogenase
XAC0794	COG1028	Short-chain dehydrogenase reductase Sdr
XAC0794	COG3321	synthase
XAC0798	COG0366	Alpha amylase catalytic
XAC0803	COG2226	methyltransferase
XAC0804	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XAC0806	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XAC0813	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XAC0815	COG4106	trans-aconitate 2-methyltransferase activity
XAC0816	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XAC0818	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XAC0819	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XAC0821	COG0667	Aldo Keto reductase
XAC0823	COG4771	TonB-dependent receptor
XAC0827	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XAC0828	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XAC0830	COG2175	clavaminate synthase activity
XAC0832	COG4181	ATPase activity
XAC0835	COG0642	Histidine kinase
XAC0837	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XAC0841	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XAC0842	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XAC0845	COG3829	transcription factor binding
XAC0847	COG1116	anion transmembrane transporter activity
XAC0848	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XAC0850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XAC0851	COG0431	NADPH-dependent FMN reductase
XAC0856	COG0747	negative chemotaxis
XAC0861	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XAC0862	COG2967	ApaG domain
XAC0863	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XAC0864	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XAC0865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XAC0866	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XAC0869	COG0123	including yeast histone deacetylase and acetoin utilization protein
XAC0870	COG2096	Adenosyltransferase
XAC0872	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XAC0873	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XAC0879	COG3384	dioxygenase
XAC0880	COG0583	DNA-binding transcription factor activity
XAC0883	COG1024	Enoyl-CoA hydratase
XAC0887	COG3386	PFAM SMP-30 Gluconolaconase
XAC0889	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XAC0892	COG0697	spore germination
XAC0893	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XAC0896	COG3706	GGDEF domain
XAC0896	COG0745	RESPONSE REGULATOR receiver
XAC0897	COG2205	protein histidine kinase activity
XAC0897	COG5002	protein histidine kinase activity
XAC0897	COG0784	Response regulator, receiver
XAC0898	COG2197	response regulator
XAC0900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XAC0902	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XAC0903	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XAC0905	COG0583	DNA-binding transcription factor activity
XAC0906	COG3634	alkyl hydroperoxide reductase activity
XAC0908	COG2890	protein-(glutamine-N5) methyltransferase activity
XAC0912	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XAC0912	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XAC0918	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XAC0923	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XAC0924	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
XAC0927	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XAC0928	COG1404	Belongs to the peptidase S8 family
XAC0929	COG1404	Belongs to the peptidase S8 family
XAC0930	COG1404	Belongs to the peptidase S8 family
XAC0931	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XAC0937	COG1295	ribonuclease BN
XAC0938	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XAC0939	COG1254	Belongs to the acylphosphatase family
XAC0942	COG0521	Mo-molybdopterin cofactor biosynthetic process
XAC0944	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XAC0945	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XAC0947	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XAC0948	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XAC0950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XAC0951	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XAC0952	COG0193	aminoacyl-tRNA hydrolase activity
XAC0953	COG0012	GTP binding
XAC0957	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XAC0959	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XAC0960	COG0250	Participates in transcription elongation, termination and antitermination
XAC0961	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XAC0962	COG0081	regulation of translation
XAC0963	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XAC0964	COG0222	ribosome binding
XAC0965	COG0085	RNA polymerase activity
XAC0966	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XAC0967	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XAC0968	COG0049	tRNA binding
XAC0969	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XAC0970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XAC0971	COG0051	transcription antitermination factor activity, RNA binding
XAC0972	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XAC0973	COG0088	Forms part of the polypeptide exit tunnel
XAC0974	COG0089	rRNA binding
XAC0975	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XAC0976	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XAC0977	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XAC0978	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XAC0979	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XAC0980	COG0255	Belongs to the universal ribosomal protein uL29 family
XAC0981	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XAC0982	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
XAC0983	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XAC0984	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XAC0985	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XAC0986	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XAC0987	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XAC0988	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XAC0989	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XAC0990	COG1841	ribosomal large subunit assembly
XAC0991	COG0200	Binds to the 23S rRNA
XAC0992	COG0201	protein transport
XAC0993	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XAC0994	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
XAC0995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XAC0996	COG0202	RNA polymerase activity
XAC0997	COG0203	ribosomal protein L17
XAC0998	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XAC1000	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XAC1002	COG0154	amidase activity
XAC1005	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XAC1006	COG0039	L-malate dehydrogenase activity
XAC1007	COG0625	glutathione transferase activity
XAC1010	COG1902	pentaerythritol trinitrate reductase activity
XAC1010	COG0446	pyridine nucleotide-disulphide oxidoreductase
XAC1011	COG0604	alcohol dehydrogenase
XAC1016	COG0156	8-amino-7-oxononanoate synthase activity
XAC1017	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XAC1018	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XAC1019	COG4208	sulfate ABC transporter
XAC1020	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XAC1022	COG1063	alcohol dehydrogenase
XAC1028	COG0406	alpha-ribazole phosphatase activity
XAC1029	COG0285	dihydrofolate synthase activity
XAC1033	COG2833	Protein of unknown function (DUF455)
XAC1034	COG3291	Pkd domain containing protein
XAC1036	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAC1037	COG0671	phosphoesterase, PA-phosphatase related
XAC1038	COG0438	transferase activity, transferring glycosyl groups
XAC1040	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XAC1043	COG4783	chaperone-mediated protein folding
XAC1046	COG0473	3-isopropylmalate dehydrogenase activity
XAC1052	COG2801	Transposase and inactivated derivatives
XAC1053	COG2963	transposase activity
XAC1070	COG2963	transposase activity
XAC1074	COG3852	Histidine kinase
XAC1077	COG0544	peptidyl-prolyl cis-trans isomerase activity
XAC1078	COG0740	serine-type endopeptidase activity
XAC1079	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XAC1085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XAC1087	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XAC1089	COG0328	RNA-DNA hybrid ribonuclease activity
XAC1090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XAC1091	COG0631	protein serine/threonine phosphatase activity
XAC1094	COG0859	PFAM glycosyl transferase family 9
XAC1095	COG3642	lipopolysaccharide core region biosynthetic process
XAC1096	COG1234	tRNA 3'-trailer cleavage
XAC1097	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XAC1098	COG0315	cyclic pyranopterin monophosphate synthase activity
XAC1099	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XAC1100	COG0314	molybdopterin synthase activity
XAC1102	COG2963	transposase activity
XAC1103	COG2801	Transposase and inactivated derivatives
XAC1110	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XAC1111	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XAC1112	COG0537	adenosine 5'-monophosphoramidase activity
XAC1116	COG0714	Associated with various cellular activities
XAC1120	COG0424	maF-like protein
XAC1121	COG1399	metal-binding, possibly nucleic acid-binding protein
XAC1122	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XAC1123	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XAC1127	COG1028	Short-chain dehydrogenase reductase Sdr
XAC1128	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XAC1130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XAC1131	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XAC1136	COG3829	transcription factor binding
XAC1140	COG3609	addiction module antidote protein, CC2985 family
XAC1145	COG2373	Large extracellular alpha-helical protein
XAC1148	COG4953	penicillin-binding protein 1C
XAC1150	COG0678	peroxiredoxin activity
XAC1155	COG0330	HflC and HflK could
XAC1156	COG0330	HflC and HflK could
XAC1158	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XAC1159	COG0308	aminopeptidase N
XAC1160	COG1028	Short-chain dehydrogenase reductase Sdr
XAC1161	COG1309	transcriptional regulator
XAC1169	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XAC1174	COG0406	alpha-ribazole phosphatase activity
XAC1174	COG0328	RNA-DNA hybrid ribonuclease activity
XAC1175	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XAC1177	COG3387	PFAM Glycoside hydrolase 15-related
XAC1178	COG1028	Short-chain dehydrogenase reductase Sdr
XAC1179	COG3537	Alpha-1,2-mannosidase
XAC1182	COG0492	ferredoxin-NADP+ reductase activity
XAC1187	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XAC1188	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XAC1189	COG2080	2 iron, 2 sulfur cluster binding
XAC1196	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XAC1199	COG0587	DNA-directed DNA polymerase activity
XAC1202	COG1297	OPT oligopeptide transporter protein
XAC1204	COG0823	Involved in the tonB-independent uptake of proteins
XAC1204	COG1506	peptidase
XAC1207	COG2207	Transcriptional regulator
XAC1207	COG1917	Cupin 2, conserved barrel domain protein
XAC1211	COG0753	catalase activity
XAC1212	COG0656	L-ascorbic acid biosynthetic process
XAC1214	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XAC1214	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XAC1215	COG2814	Major facilitator Superfamily
XAC1218	COG2194	sulfuric ester hydrolase activity
XAC1221	COG0745	RESPONSE REGULATOR receiver
XAC1222	COG0642	Histidine kinase
XAC1224	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XAC1225	COG2894	cell division
XAC1226	COG0850	regulation of cytokinetic process
XAC1228	COG4585	Histidine kinase
XAC1229	COG2197	response regulator
XAC1232	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XAC1237	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
XAC1239	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XAC1243	COG1946	Acyl-CoA thioesterase
XAC1246	COG0824	Thioesterase
XAC1247	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XAC1248	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XAC1249	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XAC1250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XAC1251	COG0268	Binds directly to 16S ribosomal RNA
XAC1253	COG0196	riboflavin kinase activity
XAC1254	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XAC1255	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XAC1256	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XAC1259	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XAC1260	COG1845	cytochrome c oxidase, subunit III
XAC1261	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XAC1264	COG3152	Membrane
XAC1266	COG2207	Transcriptional regulator
XAC1267	COG0326	Molecular chaperone. Has ATPase activity
XAC1269	COG1366	Belongs to the anti-sigma-factor antagonist family
XAC1270	COG1366	Belongs to the anti-sigma-factor antagonist family
XAC1271	COG2172	sigma factor antagonist activity
XAC1276	COG4771	TonB-dependent receptor
XAC1278	COG5507	3-demethylubiquinone-9 3-methyltransferase
XAC1279	COG2205	protein histidine kinase activity
XAC1281	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XAC1282	COG0784	Response regulator, receiver
XAC1282	COG4191	Histidine kinase
XAC1283	COG2205	protein histidine kinase activity
XAC1283	COG3437	response regulator, receiver
XAC1283	COG4999	Histidine kinase
XAC1283	COG3850	Histidine kinase
XAC1288	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XAC1289	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XAC1291	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XAC1292	COG0228	four-way junction DNA binding
XAC1293	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XAC1294	COG0336	Belongs to the RNA methyltransferase TrmD family
XAC1295	COG0335	large ribosomal subunit rRNA binding
XAC1296	COG0534	Mate efflux family protein
XAC1297	COG0534	Mate efflux family protein
XAC1301	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XAC1303	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XAC1305	COG3209	COG3209 Rhs family protein
XAC1308	COG3250	beta-galactosidase activity
XAC1309	COG3867	Arabinogalactan endo-beta-1,4-galactanase
XAC1313	COG1960	acyl-CoA dehydrogenase activity
XAC1314	COG1024	Enoyl-CoA hydratase
XAC1318	COG1024	Enoyl-CoA hydratase
XAC1318	COG1250	3-hydroxyacyl-CoA dehydrogenase
XAC1321	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XAC1322	COG0481	GTPase activity
XAC1325	COG0571	ribonuclease III activity
XAC1326	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XAC1327	COG1381	Involved in DNA repair and RecF pathway recombination
XAC1329	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XAC1331	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XAC1332	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
XAC1333	COG3046	protein related to deoxyribodipyrimidine photolyase
XAC1334	COG1472	Belongs to the glycosyl hydrolase 3 family
XAC1336	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XAC1337	COG1278	Cold shock
XAC1338	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XAC1340	COG1201	RNA secondary structure unwinding
XAC1341	COG1793	dna ligase
XAC1342	COG1793	dna ligase
XAC1342	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XAC1345	COG3706	GGDEF domain
XAC1345	COG0745	RESPONSE REGULATOR receiver
XAC1348	COG0183	Belongs to the thiolase family
XAC1352	COG1451	nucleotide metabolic process
XAC1353	COG5487	UPF0391 membrane protein
XAC1355	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XAC1357	COG1077	Cell shape determining protein MreB Mrl
XAC1358	COG1047	Peptidyl-prolyl cis-trans
XAC1360	COG2824	Alkylphosphonate utilization operon protein PhnA
XAC1362	COG1902	pentaerythritol trinitrate reductase activity
XAC1363	COG2814	Major facilitator Superfamily
XAC1369	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XAC1369	COG0392	lysyltransferase activity
XAC1371	COG0251	oxidation-reduction process
XAC1372	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XAC1375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XAC1380	COG1595	DNA-templated transcription, initiation
XAC1384	COG2878	Part of a membrane complex involved in electron transport
XAC1386	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XAC1386	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XAC1389	COG1131	(ABC) transporter
XAC1390	COG0346	lactoylglutathione lyase activity
XAC1391	COG0833	amino acid
XAC1392	COG2040	homocysteine
XAC1394	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XAC1398	COG1695	Transcriptional regulator
XAC1405	COG0825	malonyl-CoA metabolic process
XAC1407	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XAC1408	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAC1409	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAC1410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XAC1411	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XAC1414	COG0750	zinc metalloprotease
XAC1415	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XAC1416	COG0575	Belongs to the CDS family
XAC1417	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XAC1418	COG0233	cytoplasmic translational termination
XAC1419	COG0528	UMP kinase activity
XAC1420	COG3706	GGDEF domain
XAC1420	COG0745	RESPONSE REGULATOR receiver
XAC1421	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XAC1422	COG0052	Belongs to the universal ribosomal protein uS2 family
XAC1428	COG0024	Methionine aminopeptidase
XAC1429	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XAC1431	COG1393	Belongs to the ArsC family
XAC1432	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XAC1433	COG0367	asparagine synthase
XAC1435	COG4774	siderophore transport
XAC1439	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XAC1445	COG1566	PFAM secretion protein HlyD family protein
XAC1446	COG2814	Major facilitator Superfamily
XAC1450	COG3104	oligopeptide transport
XAC1456	COG0339	signal peptide processing
XAC1457	COG0386	Belongs to the glutathione peroxidase family
XAC1467	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XAC1469	COG0084	hydrolase, TatD family'
XAC1472	COG1960	acyl-CoA dehydrogenase activity
XAC1475	COG0367	asparagine synthase
XAC1477	COG0305	Participates in initiation and elongation during chromosome replication
XAC1478	COG0415	Belongs to the DNA photolyase family
XAC1480	COG0583	DNA-binding transcription factor activity
XAC1486	COG3706	GGDEF domain
XAC1488	COG3706	GGDEF domain
XAC1513	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XAC1516	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAC1519	COG0497	DNA recombination
XAC1520	COG1420	regulation of RNA biosynthetic process
XAC1521	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XAC1522	COG0443	Heat shock 70 kDa protein
XAC1523	COG0484	heat shock protein binding
XAC1524	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XAC1529	COG0583	DNA-binding transcription factor activity
XAC1530	COG1132	(ABC) transporter
XAC1537	COG2850	peptidyl-arginine hydroxylation
XAC1541	COG1253	flavin adenine dinucleotide binding
XAC1547	COG1131	(ABC) transporter
XAC1548	COG1725	Transcriptional regulator
XAC1549	COG0386	Belongs to the glutathione peroxidase family
XAC1552	COG2900	Belongs to the SlyX family
XAC1557	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XAC1559	COG1410	methionine synthase
XAC1559	COG0646	methionine synthase
XAC1560	COG0646	methionine synthase
XAC1560	COG1410	methionine synthase
XAC1562	COG1960	acyl-CoA dehydrogenase activity
XAC1567	COG0557	exoribonuclease II activity
XAC1569	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XAC1570	COG3706	GGDEF domain
XAC1571	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XAC1573	COG0704	Plays a role in the regulation of phosphate uptake
XAC1574	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XAC1575	COG0581	inorganic phosphate transmembrane transporter activity
XAC1576	COG0573	inorganic phosphate transmembrane transporter activity
XAC1577	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XAC1581	COG0659	secondary active sulfate transmembrane transporter activity
XAC1582	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XAC1584	COG1024	Enoyl-CoA hydratase
XAC1586	COG0494	nUDIX hydrolase
XAC1594	COG0116	Belongs to the methyltransferase superfamily
XAC1594	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XAC1595	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XAC1599	COG2925	Exonuclease
XAC1600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XAC1601	COG3844	kynureninase activity
XAC1603	COG0662	Cupin 2, conserved barrel domain protein
XAC1604	COG0288	reversible hydration of carbon dioxide
XAC1615	COG2808	Putative FMN-binding domain
XAC1618	COG0017	Asparaginyl-tRNA synthetase
XAC1619	COG0316	Belongs to the HesB IscA family
XAC1620	COG0360	Binds together with S18 to 16S ribosomal RNA
XAC1621	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XAC1622	COG0359	binds to the 23S rRNA
XAC1624	COG3115	cell septum assembly
XAC1626	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XAC1627	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XAC1628	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XAC1630	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XAC1633	COG4993	Dehydrogenase
XAC1635	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XAC1637	COG2986	histidine ammonia-lyase
XAC1638	COG1228	amidohydrolase
XAC1646	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
XAC1647	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XAC1648	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XAC1649	COG1605	Chorismate mutase
XAC1649	COG0077	Prephenate dehydratase
XAC1650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XAC1653	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XAC1654	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XAC1655	COG0583	DNA-binding transcription factor activity
XAC1660	COG2963	transposase activity
XAC1666	COG0840	transmembrane signaling receptor activity
XAC1670	COG0745	RESPONSE REGULATOR receiver
XAC1671	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XAC1672	COG4191	Histidine kinase
XAC1672	COG0784	Response regulator, receiver
XAC1675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XAC1677	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XAC1679	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XAC1682	COG1595	DNA-templated transcription, initiation
XAC1692	COG2244	polysaccharide biosynthetic process
XAC1698	COG2264	protein methyltransferase activity
XAC1700	COG0438	transferase activity, transferring glycosyl groups
XAC1703	COG1136	(ABC) transporter
XAC1705	COG0477	Major facilitator Superfamily
XAC1706	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XAC1709	COG1253	flavin adenine dinucleotide binding
XAC1711	COG0306	phosphate transporter
XAC1716	COG0504	CTP synthase activity
XAC1717	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XAC1719	COG0148	phosphopyruvate hydratase activity
XAC1720	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XAC1721	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XAC1722	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XAC1723	COG0585	pseudouridine synthase activity
XAC1724	COG2840	Smr protein MutS2
XAC1725	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XAC1726	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XAC1727	COG1238	metal cluster binding
XAC1730	COG1534	Rna-binding protein
XAC1731	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XAC1732	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XAC1733	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XAC1734	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XAC1735	COG1923	regulation of RNA biosynthetic process
XAC1736	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XAC1737	COG1546	Belongs to the CinA family
XAC1739	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XAC1740	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XAC1741	COG2137	regulation of response to DNA damage stimulus
XAC1742	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XAC1743	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XAC1747	COG1741	Belongs to the pirin family
XAC1748	COG0583	DNA-binding transcription factor activity
XAC1753	COG0352	thiamine-phosphate diphosphorylase activity
XAC1753	COG0351	phosphomethylpyrimidine kinase
XAC1756	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XAC1757	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XAC1760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XAC1762	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XAC1763	COG3734	2-keto-3-deoxy-galactonokinase
XAC1765	COG4948	Mandelate Racemase Muconate Lactonizing
XAC1766	COG0800	Aldolase
XAC1773	COG1501	Belongs to the glycosyl hydrolase 31 family
XAC1775	COG1070	Carbohydrate kinase
XAC1776	COG2115	Belongs to the xylose isomerase family
XAC1777	COG0477	Major facilitator Superfamily
XAC1780	COG0860	N-Acetylmuramoyl-L-alanine amidase
XAC1781	COG1469	GTP cyclohydrolase I activity
XAC1785	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XAC1786	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XAC1787	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XAC1788	COG0166	Belongs to the GPI family
XAC1793	COG1472	Belongs to the glycosyl hydrolase 3 family
XAC1795	COG5001	Diguanylate cyclase
XAC1795	COG4251	negative regulation of phosphorylation
XAC1795	COG3706	GGDEF domain
XAC1795	COG2203	Gaf domain
XAC1796	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XAC1797	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XAC1799	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XAC1800	COG0671	phosphoesterase, PA-phosphatase related
XAC1802	COG1794	racemase activity, acting on amino acids and derivatives
XAC1803	COG0697	spore germination
XAC1804	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XAC1805	COG0167	dihydroorotate dehydrogenase activity
XAC1808	COG1012	belongs to the aldehyde dehydrogenase family
XAC1811	COG1215	transferase activity, transferring glycosyl groups
XAC1812	COG0726	polysaccharide deacetylase
XAC1812	COG1649	PFAM Uncharacterised BCR, COG1649
XAC1815	COG3210	domain, Protein
XAC1816	COG3210	domain, Protein
XAC1825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XAC1826	COG0124	histidyl-tRNA synthetase
XAC1828	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XAC1829	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XAC1830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XAC1831	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XAC1831	COG0131	Imidazoleglycerol-phosphate dehydratase
XAC1832	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XAC1833	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XAC1834	COG0107	imidazoleglycerol-phosphate synthase activity
XAC1835	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XAC1835	COG0140	phosphoribosyl-ATP diphosphatase activity
XAC1838	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XAC1839	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XAC1840	COG0235	Class ii aldolase
XAC1841	COG0531	amino acid
XAC1842	COG0531	amino acid
XAC1844	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XAC1845	COG0277	FAD linked oxidase domain protein
XAC1849	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XAC1858	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XAC1859	COG2258	MOSC domain
XAC1860	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XAC1861	COG0505	Belongs to the CarA family
XAC1862	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XAC1863	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XAC1865	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XAC1874	COG3279	Response regulator of the LytR AlgR family
XAC1875	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XAC1876	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XAC1878	COG2205	protein histidine kinase activity
XAC1878	COG0784	Response regulator, receiver
XAC1878	COG2198	Histidine kinase
XAC1879	COG1024	Enoyl-CoA hydratase
XAC1880	COG0318	PFAM AMP-dependent synthetase and ligase
XAC1886	COG2267	carboxylic ester hydrolase activity
XAC1888	COG2201	protein-glutamate methylesterase activity
XAC1889	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
XAC1891	COG0840	transmembrane signaling receptor activity
XAC1892	COG0840	transmembrane signaling receptor activity
XAC1893	COG0840	transmembrane signaling receptor activity
XAC1894	COG0840	transmembrane signaling receptor activity
XAC1895	COG0840	transmembrane signaling receptor activity
XAC1896	COG0840	transmembrane signaling receptor activity
XAC1897	COG0840	transmembrane signaling receptor activity
XAC1899	COG0840	transmembrane signaling receptor activity
XAC1900	COG0840	transmembrane signaling receptor activity
XAC1900	COG0840	transmembrane signaling receptor activity
XAC1902	COG0840	transmembrane signaling receptor activity
XAC1903	COG0643	Histidine kinase
XAC1903	COG2198	Histidine kinase
XAC1904	COG0745	RESPONSE REGULATOR receiver
XAC1906	COG0835	chemotaxis
XAC1907	COG1192	Involved in chromosome partitioning
XAC1908	COG1360	Flagellar Motor Protein
XAC1909	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XAC1920	COG2801	Transposase and inactivated derivatives
XAC1921	COG2963	transposase activity
XAC1927	COG0641	radical SAM
XAC1930	COG0643	Histidine kinase
XAC1930	COG2198	Histidine kinase
XAC1934	COG0455	bacterial-type flagellum organization
XAC1936	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XAC1939	COG5001	Diguanylate cyclase
XAC1939	COG3300	MHYT domain
XAC1940	COG5001	Diguanylate cyclase
XAC1940	COG3300	MHYT domain
XAC1941	COG1684	flagellar biosynthetic protein fliR
XAC1942	COG1987	bacterial-type flagellum assembly
XAC1945	COG3190	flagellar
XAC1955	COG1677	Flagellar hook-basal body complex protein FliE
XAC1962	COG1028	Short-chain dehydrogenase reductase Sdr
XAC1963	COG1028	Short-chain dehydrogenase reductase Sdr
XAC1964	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XAC1967	COG2204	response regulator
XAC1968	COG2201	protein-glutamate methylesterase activity
XAC1974	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
XAC1975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XAC1976	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XAC1978	COG3951	Flagellar rod assembly protein muramidase FlgJ
XAC1978	COG1705	Flagellar rod assembly protein muramidase FlgJ
XAC1979	COG1706	bacterial-type flagellum-dependent cell motility
XAC1980	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XAC1981	COG4786	Flagellar basal body rod
XAC1982	COG4787	bacterial-type flagellum-dependent cell motility
XAC1983	COG1749	Flagellar hook protein flgE
XAC1984	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XAC1985	COG1558	bacterial-type flagellum-dependent cell motility
XAC1987	COG0835	chemotaxis
XAC1987	COG0784	Response regulator, receiver
XAC1991	COG5002	protein histidine kinase activity
XAC1997	COG2915	High frequency lysogenization protein hflD homolog
XAC1998	COG0482	sulfurtransferase activity
XAC2000	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XAC2001	COG0542	response to heat
XAC2002	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
XAC2003	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XAC2005	COG0492	ferredoxin-NADP+ reductase activity
XAC2006	COG1674	ftsk spoiiie
XAC2008	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XAC2010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XAC2011	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XAC2012	COG0183	Belongs to the thiolase family
XAC2013	COG1024	Enoyl-CoA hydratase
XAC2013	COG1250	3-hydroxyacyl-CoA dehydrogenase
XAC2015	COG0105	UTP biosynthetic process
XAC2016	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XAC2018	COG1426	Protein conserved in bacteria
XAC2020	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAC2021	COG1160	GTP binding
XAC2022	COG0303	'Molybdopterin
XAC2023	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XAC2030	COG0708	Exodeoxyribonuclease III
XAC2032	COG0303	'Molybdopterin
XAC2033	COG0746	molybdenum cofactor guanylyltransferase activity
XAC2036	COG1914	H( )-stimulated, divalent metal cation uptake system
XAC2037	COG1321	iron dependent repressor
XAC2038	COG0590	tRNA wobble adenosine to inosine editing
XAC2039	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XAC2040	COG0668	transmembrane transport
XAC2042	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XAC2045	COG1028	Short-chain dehydrogenase reductase Sdr
XAC2046	COG1183	phosphatidylcholine synthase activity
XAC2048	COG3243	poly(R)-hydroxyalkanoic acid synthase
XAC2051	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAC2051	COG0723	plastoquinol--plastocyanin reductase activity
XAC2053	COG2183	response to ionizing radiation
XAC2054	COG2205	protein histidine kinase activity
XAC2054	COG0784	Response regulator, receiver
XAC2067	COG0800	Aldolase
XAC2068	COG0129	dihydroxy-acid dehydratase activity
XAC2069	COG0363	glucosamine-6-phosphate deaminase activity
XAC2070	COG0837	glucose binding
XAC2071	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XAC2076	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XAC2078	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XAC2079	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XAC2081	COG4591	ABC-type transport system involved in lipoprotein release permease component
XAC2082	COG1136	(ABC) transporter
XAC2085	COG0811	peptide transport
XAC2087	COG1132	(ABC) transporter
XAC2088	COG1663	tetraacyldisaccharide 4'-kinase activity
XAC2089	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XAC2090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XAC2092	COG0322	excinuclease ABC activity
XAC2093	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XAC2097	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XAC2098	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XAC2102	COG2963	transposase activity
XAC2103	COG0582	viral genome integration into host DNA
XAC2105	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XAC2111	COG1530	ribonuclease E activity
XAC2113	COG3064	Membrane
XAC2114	COG0428	transporter
XAC2116	COG2154	pterin-4-alpha-carbinolamine dehydratase
XAC2117	COG0316	Belongs to the HesB IscA family
XAC2117	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XAC2126	COG1073	alpha beta
XAC2126	COG2226	methyltransferase
XAC2129	COG1028	Short-chain dehydrogenase reductase Sdr
XAC2131	COG2801	Transposase and inactivated derivatives
XAC2132	COG2963	transposase activity
XAC2134	COG1238	metal cluster binding
XAC2141	COG3279	Response regulator of the LytR AlgR family
XAC2150	COG4566	intracellular signal transduction
XAC2152	COG5001	Diguanylate cyclase
XAC2155	COG3685	Protein conserved in bacteria
XAC2159	COG1648	precorrin-2 dehydrogenase activity
XAC2159	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XAC2161	COG2814	Major facilitator Superfamily
XAC2165	COG1335	isochorismatase
XAC2168	COG2197	response regulator
XAC2171	COG0583	DNA-binding transcription factor activity
XAC2172	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XAC2173	COG3002	Belongs to the UPF0753 family
XAC2174	COG2801	Transposase and inactivated derivatives
XAC2175	COG2963	transposase activity
XAC2176	COG1396	sequence-specific DNA binding
XAC2178	COG5489	Protein of unknown function (DUF736)
XAC2179	COG2003	Belongs to the UPF0758 family
XAC2183	COG0582	viral genome integration into host DNA
XAC2185	COG4774	siderophore transport
XAC2188	COG2336	PFAM SpoVT AbrB
XAC2193	COG4206	TonB-dependent receptor
XAC2197	COG2273	Hydrolase Family 16
XAC2197	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
XAC2202	COG2274	protein secretion by the type I secretion system
XAC2205	COG1192	Involved in chromosome partitioning
XAC2212	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XAC2213	COG0270	DNA (cytosine-5-)-methyltransferase activity
XAC2223	COG4804	nuclease activity
XAC2224	COG2963	transposase activity
XAC2225	COG2801	Transposase and inactivated derivatives
XAC2226	COG5006	permease, DMT superfamily
XAC2229	COG2249	NAD(P)H dehydrogenase (quinone) activity
XAC2231	COG3938	Belongs to the proline racemase family
XAC2232	COG0655	NAD(P)H dehydrogenase (quinone) activity
XAC2234	COG2807	transmembrane transport
XAC2235	COG2207	Transcriptional regulator
XAC2265	COG0210	DNA helicase
XAC2277	COG2084	Dehydrogenase
XAC2281	COG2003	Belongs to the UPF0758 family
XAC2286	COG0582	viral genome integration into host DNA
XAC2287	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XAC2287	COG0519	Catalyzes the synthesis of GMP from XMP
XAC2289	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XAC2291	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XAC2291	COG0475	glutathione-regulated potassium exporter activity
XAC2292	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XAC2294	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XAC2295	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XAC2297	COG0776	regulation of translation
XAC2298	COG0539	negative regulation of cytoplasmic translation
XAC2299	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XAC2300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
XAC2302	COG2957	Belongs to the agmatine deiminase family
XAC2303	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XAC2308	COG0395	ABC-type sugar transport system, permease component
XAC2309	COG1175	transmembrane transport
XAC2315	COG2350	Protein conserved in bacteria
XAC2316	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XAC2317	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XAC2318	COG1187	pseudouridine synthase activity
XAC2322	COG0436	Aminotransferase
XAC2323	COG4133	protoheme IX ABC transporter activity
XAC2327	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XAC2328	COG1138	Cytochrome C-type biogenesis protein
XAC2332	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XAC2333	COG1278	Cold shock
XAC2334	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XAC2335	COG4988	ABC transporter
XAC2337	COG1294	oxidase, subunit
XAC2342	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XAC2343	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XAC2345	COG0165	Argininosuccinate lyase
XAC2346	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XAC2348	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XAC2351	COG0137	argininosuccinate synthase activity
XAC2352	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XAC2354	COG0215	cysteine-tRNA ligase activity
XAC2355	COG2166	iron-sulfur cluster assembly
XAC2358	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XAC2359	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XAC2360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XAC2366	COG4302	ethanolamine ammonia-lyase activity
XAC2371	COG2801	Transposase and inactivated derivatives
XAC2372	COG2963	transposase activity
XAC2377	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XAC2378	COG0402	S-adenosylhomocysteine deaminase activity
XAC2380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XAC2381	COG1509	lysine 2,3-aminomutase activity
XAC2382	COG3300	MHYT domain
XAC2382	COG5001	Diguanylate cyclase
XAC2385	COG0483	inositol monophosphate 1-phosphatase activity
XAC2390	COG0513	Belongs to the DEAD box helicase family
XAC2391	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XAC2392	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XAC2394	COG0625	glutathione transferase activity
XAC2396	COG4681	YaeQ
XAC2397	COG2081	HI0933 family
XAC2399	COG0501	Belongs to the peptidase M48B family
XAC2400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XAC2401	COG1028	Short-chain dehydrogenase reductase Sdr
XAC2405	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XAC2406	COG0860	N-Acetylmuramoyl-L-alanine amidase
XAC2407	COG0802	atpase or kinase
XAC2408	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XAC2408	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XAC2409	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XAC2410	COG1570	exodeoxyribonuclease VII activity
XAC2412	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XAC2447	COG0835	chemotaxis
XAC2448	COG0840	transmembrane signaling receptor activity
XAC2449	COG2094	Belongs to the DNA glycosylase MPG family
XAC2450	COG1201	RNA secondary structure unwinding
XAC2453	COG2969	positive regulation of protein catabolic process
XAC2454	COG0625	glutathione transferase activity
XAC2455	COG2857	Cytochrome c1
XAC2456	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XAC2457	COG0723	plastoquinol--plastocyanin reductase activity
XAC2458	COG0741	lytic transglycosylase activity
XAC2461	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XAC2462	COG1702	phosphate starvation-inducible protein PhoH
XAC2464	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XAC2466	COG4535	Mg2 and Co2 transporter CorC
XAC2469	COG1012	belongs to the aldehyde dehydrogenase family
XAC2470	COG1177	transmembrane transport
XAC2471	COG1176	ABC-type spermidine putrescine transport system, permease component I
XAC2472	COG3842	ATPase activity
XAC2476	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XAC2479	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XAC2480	COG0174	glutamine synthetase
XAC2481	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAC2482	COG3706	GGDEF domain
XAC2482	COG0745	RESPONSE REGULATOR receiver
XAC2483	COG2703	oxygen carrier activity
XAC2484	COG0477	Major facilitator Superfamily
XAC2486	COG0243	molybdopterin cofactor binding
XAC2487	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XAC2491	COG2733	membrane
XAC2492	COG0784	Response regulator, receiver
XAC2492	COG5002	protein histidine kinase activity
XAC2492	COG2205	protein histidine kinase activity
XAC2494	COG0477	Major facilitator Superfamily
XAC2496	COG2902	Dehydrogenase
XAC2498	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAC2499	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XAC2500	COG1609	Transcriptional regulator
XAC2501	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XAC2501	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XAC2502	COG1105	Belongs to the carbohydrate kinase PfkB family
XAC2503	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XAC2503	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XAC2510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XAC2512	COG1862	Preprotein translocase
XAC2513	COG0343	queuine tRNA-ribosyltransferase activity
XAC2514	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XAC2521	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XAC2522	COG3291	Pkd domain containing protein
XAC2523	COG0405	Gamma-glutamyltransferase
XAC2524	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XAC2526	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XAC2527	COG0742	ribosomal rna small subunit methyltransferase
XAC2528	COG0326	Molecular chaperone. Has ATPase activity
XAC2542	COG0531	amino acid
XAC2545	COG0006	proline dipeptidase activity
XAC2547	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XAC2549	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAC2550	COG3938	Belongs to the proline racemase family
XAC2552	COG0552	protein localization to endoplasmic reticulum
XAC2553	COG1194	a g-specific adenine glycosylase
XAC2554	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XAC2555	COG0784	Response regulator, receiver
XAC2555	COG4191	Histidine kinase
XAC2558	COG0322	excinuclease ABC activity
XAC2561	COG3040	lipid binding
XAC2563	COG1960	acyl-CoA dehydrogenase activity
XAC2565	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XAC2569	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XAC2570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XAC2571	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XAC2578	COG0438	transferase activity, transferring glycosyl groups
XAC2579	COG0438	transferase activity, transferring glycosyl groups
XAC2588	COG0776	regulation of translation
XAC2589	COG0072	phenylalanine-tRNA ligase activity
XAC2589	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XAC2590	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XAC2591	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
XAC2592	COG0291	Belongs to the bacterial ribosomal protein bL35 family
XAC2593	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XAC2594	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XAC2599	COG1082	Xylose isomerase domain protein TIM barrel
XAC2602	COG0366	Alpha amylase catalytic
XAC2603	COG2963	transposase activity
XAC2604	COG2801	Transposase and inactivated derivatives
XAC2615	COG3702	type iv secretory pathway
XAC2619	COG2948	multi-organism process
XAC2623	COG3505	Type IV secretory pathway VirD4
XAC2625	COG0556	nucleotide-excision repair
XAC2633	COG2963	transposase activity
XAC2634	COG2801	Transposase and inactivated derivatives
XAC2641	COG4695	Portal protein
XAC2650	COG3179	chitinase
XAC2661	COG2801	Transposase and inactivated derivatives
XAC2662	COG2963	transposase activity
XAC2670	COG3275	phosphorelay sensor kinase activity
XAC2671	COG1611	Belongs to the LOG family
XAC2674	COG2095	MarC family integral membrane protein
XAC2676	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XAC2677	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XAC2683	COG1185	polyribonucleotide nucleotidyltransferase activity
XAC2684	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XAC2685	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XAC2686	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XAC2687	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XAC2688	COG0195	Participates in both transcription termination and antitermination
XAC2689	COG0779	Required for maturation of 30S ribosomal subunits
XAC2691	COG1007	ATP synthesis coupled electron transport
XAC2694	COG0713	ATP synthesis coupled electron transport
XAC2696	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAC2697	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XAC2699	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XAC2700	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XAC2701	COG0649	NAD binding
XAC2702	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAC2703	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAC2704	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XAC2706	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XAC2707	COG0149	triose-phosphate isomerase activity
XAC2708	COG0300	oxidoreductase activity
XAC2714	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XAC2715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XAC2716	COG0159	tryptophan synthase activity
XAC2717	COG0133	tryptophan synthase activity
XAC2719	COG0135	phosphoribosylanthranilate isomerase activity
XAC2720	COG0101	tRNA pseudouridine synthase activity
XAC2723	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XAC2724	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XAC2725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XAC2726	COG2890	protein-(glutamine-N5) methyltransferase activity
XAC2728	COG0688	phosphatidylethanolamine metabolic process
XAC2730	COG0433	COG0433 Predicted ATPase
XAC2731	COG0494	nUDIX hydrolase
XAC2734	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XAC2735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XAC2740	COG0717	Belongs to the dCTP deaminase family
XAC2741	COG0489	protein tyrosine kinase activity
XAC2745	COG3590	peptidase
XAC2746	COG3590	peptidase
XAC2750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XAC2751	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAC2752	COG2311	Membrane
XAC2753	COG0791	NLP P60 protein
XAC2754	COG1047	Peptidyl-prolyl cis-trans
XAC2755	COG0791	NLP P60 protein
XAC2757	COG4106	trans-aconitate 2-methyltransferase activity
XAC2758	COG1301	dicarboxylic acid transport
XAC2759	COG1785	Belongs to the alkaline phosphatase family
XAC2760	COG0037	tRNA processing
XAC2761	COG1722	exodeoxyribonuclease VII activity
XAC2762	COG0142	geranyltranstransferase activity
XAC2763	COG4104	PAAR repeat-containing protein
XAC2765	COG0312	modulator of DNA gyrase
XAC2766	COG3028	Belongs to the UPF0307 family
XAC2767	COG0312	modulator of DNA gyrase
XAC2769	COG3164	Protein of unknown function
XAC2770	COG1530	ribonuclease E activity
XAC2771	COG0424	maF-like protein
XAC2772	COG2968	Membrane
XAC2775	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XAC2778	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XAC2781	COG0495	leucyl-tRNA aminoacylation
XAC2783	COG3118	belongs to the thioredoxin family
XAC2788	COG2155	Conserved Protein
XAC2789	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XAC2797	COG1132	(ABC) transporter
XAC2802	COG1538	Outer membrane efflux protein
XAC2803	COG0745	RESPONSE REGULATOR receiver
XAC2804	COG5000	phosphorelay sensor kinase activity
XAC2804	COG5002	protein histidine kinase activity
XAC2805	COG0475	glutathione-regulated potassium exporter activity
XAC2806	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
XAC2807	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XAC2810	COG3706	GGDEF domain
XAC2810	COG0745	RESPONSE REGULATOR receiver
XAC2811	COG1187	pseudouridine synthase activity
XAC2812	COG5002	protein histidine kinase activity
XAC2812	COG5001	Diguanylate cyclase
XAC2835	COG0667	Aldo Keto reductase
XAC2837	COG2814	Major facilitator Superfamily
XAC2838	COG0583	DNA-binding transcription factor activity
XAC2839	COG2207	Transcriptional regulator
XAC2841	COG1309	transcriptional regulator
XAC2842	COG1538	Outer membrane efflux protein
XAC2846	COG0735	belongs to the Fur family
XAC2847	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XAC2852	COG4452	Inner membrane protein CreD
XAC2854	COG2205	protein histidine kinase activity
XAC2855	COG0745	RESPONSE REGULATOR receiver
XAC2856	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XAC2858	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XAC2865	COG0643	Histidine kinase
XAC2865	COG2198	Histidine kinase
XAC2866	COG0840	transmembrane signaling receptor activity
XAC2867	COG0835	chemotaxis
XAC2868	COG2199	diguanylate cyclase activity
XAC2868	COG2202	Pas domain
XAC2868	COG2200	EAL domain
XAC2869	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XAC2870	COG2201	protein-glutamate methylesterase activity
XAC2871	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAC2872	COG3590	peptidase
XAC2874	COG0588	phosphoglycerate mutase activity
XAC2875	COG1515	deoxyribonuclease V activity
XAC2877	COG1741	Belongs to the pirin family
XAC2880	COG1741	Belongs to the pirin family
XAC2881	COG1966	Carbon starvation protein
XAC2882	COG2879	small protein
XAC2892	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
XAC2893	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XAC2894	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XAC2895	COG2080	2 iron, 2 sulfur cluster binding
XAC2897	COG4251	negative regulation of phosphorylation
XAC2897	COG3706	GGDEF domain
XAC2897	COG5001	Diguanylate cyclase
XAC2897	COG2203	Gaf domain
XAC2905	COG0629	single-stranded DNA binding
XAC2906	COG0142	geranyltranstransferase activity
XAC2908	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XAC2911	COG0527	aspartate kinase activity
XAC2912	COG0384	phenazine biosynthesis protein PhzF
XAC2913	COG0384	phenazine biosynthesis protein PhzF
XAC2915	COG1764	response to oxidative stress
XAC2916	COG0540	Belongs to the ATCase OTCase family
XAC2917	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XAC2918	COG1678	Uncharacterized ACR, COG1678
XAC2919	COG0519	Catalyzes the synthesis of GMP from XMP
XAC2922	COG5297	Belongs to the glycosyl hydrolase family 6
XAC2925	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XAC2928	COG0739	heme binding
XAC2932	COG0693	protein deglycase activity
XAC2934	COG1959	2 iron, 2 sulfur cluster binding
XAC2935	COG0719	Fe-S assembly protein
XAC2936	COG0396	ATPase activity
XAC2937	COG0719	Fe-S assembly protein
XAC2938	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XAC2941	COG4774	siderophore transport
XAC2942	COG3128	pkhd-type hydroxylase
XAC2947	COG1477	protein flavinylation
XAC2948	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XAC2951	COG1555	photosystem II stabilization
XAC2952	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XAC2954	COG3178	'Phosphotransferase
XAC2955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XAC2957	COG0628	permease
XAC2959	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XAC2961	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XAC2965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XAC2966	COG0271	Belongs to the BolA IbaG family
XAC2968	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XAC2970	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XAC2971	COG1137	ATPase activity
XAC2974	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XAC2975	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XAC2976	COG1660	Displays ATPase and GTPase activities
XAC2978	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XAC2979	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XAC2980	COG2239	Acts as a magnesium transporter
XAC2982	COG1294	oxidase, subunit
XAC2983	COG1271	oxidase subunit
XAC2985	COG1113	amino acid transport
XAC2988	COG2197	response regulator
XAC2989	COG0531	amino acid
XAC2994	COG1234	tRNA 3'-trailer cleavage
XAC3001	COG2814	Major facilitator Superfamily
XAC3002	COG0754	glutathionylspermidine amidase activity
XAC3007	COG1842	Phage shock protein A
XAC3009	COG0259	pyridoxamine-phosphate oxidase activity
XAC3010	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XAC3011	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XAC3013	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XAC3027	COG2814	Major facilitator Superfamily
XAC3031	COG2198	Histidine kinase
XAC3031	COG2205	protein histidine kinase activity
XAC3031	COG0784	Response regulator, receiver
XAC3032	COG2353	YceI-like domain
XAC3036	COG1760	l-serine dehydratase
XAC3038	COG0527	aspartate kinase activity
XAC3038	COG0460	homoserine dehydrogenase
XAC3039	COG0626	cystathionine gamma-synthase activity
XAC3040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XAC3041	COG0739	heme binding
XAC3042	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XAC3043	COG1272	protein, Hemolysin III
XAC3044	COG2982	Protein involved in outer membrane biogenesis
XAC3045	COG0516	GMP reductase activity
XAC3045	COG0517	IMP dehydrogenase activity
XAC3046	COG0463	Glycosyl transferase, family 2
XAC3047	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XAC3048	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XAC3050	COG4771	TonB-dependent receptor
XAC3052	COG1309	transcriptional regulator
XAC3053	COG2267	carboxylic ester hydrolase activity
XAC3054	COG1960	acyl-CoA dehydrogenase activity
XAC3060	COG0509	glycine decarboxylation via glycine cleavage system
XAC3061	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XAC3063	COG0330	HflC and HflK could
XAC3064	COG1742	UPF0060 membrane protein
XAC3065	COG3956	TIGRFAM MazG family protein
XAC3067	COG0494	nUDIX hydrolase
XAC3069	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XAC3070	COG0837	glucose binding
XAC3073	COG1388	LysM domain
XAC3073	COG3858	chitin binding
XAC3074	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XAC3076	COG1472	Belongs to the glycosyl hydrolase 3 family
XAC3079	COG0531	amino acid
XAC3081	COG1486	melibiose metabolic process
XAC3083	COG3537	Alpha-1,2-mannosidase
XAC3091	COG3142	Participates in the control of copper homeostasis
XAC3092	COG1446	asparaginase
XAC3099	COG0840	transmembrane signaling receptor activity
XAC3103	COG0189	ligase activity
XAC3105	COG1397	ADP-ribosylglycohydrolase
XAC3107	COG1199	ATP-dependent helicase activity
XAC3109	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XAC3110	COG1215	transferase activity, transferring glycosyl groups
XAC3113	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XAC3114	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
XAC3115	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
XAC3116	COG0535	radical SAM domain protein
XAC3117	COG0535	radical SAM domain protein
XAC3120	COG0837	glucose binding
XAC3122	COG1643	Atp-dependent helicase
XAC3123	COG0783	Belongs to the Dps family
XAC3124	COG0514	ATP-dependent DNA helicase (RecQ)
XAC3132	COG0840	transmembrane signaling receptor activity
XAC3136	COG3920	Histidine kinase
XAC3137	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XAC3139	COG0602	queuosine metabolic process
XAC3141	COG2885	chlorophyll binding
XAC3142	COG0823	Involved in the tonB-independent uptake of proteins
XAC3144	COG0848	biopolymer transport protein
XAC3146	COG0824	Thioesterase
XAC3147	COG2255	four-way junction helicase activity
XAC3148	COG3158	transport of potassium into the cell
XAC3149	COG0632	four-way junction helicase activity
XAC3150	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XAC3151	COG0217	transcriptional regulatory protein
XAC3154	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XAC3157	COG0477	Major facilitator Superfamily
XAC3165	COG0488	(ABC) transporter
XAC3171	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XAC3171	COG4651	solute:proton antiporter activity
XAC3176	COG4772	TonB-dependent receptor
XAC3178	COG4264	IucA IucC family
XAC3181	COG0019	diaminopimelate decarboxylase activity
XAC3186	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XAC3188	COG1492	cobalamin metabolic process
XAC3190	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XAC3194	COG4206	TonB-dependent receptor
XAC3195	COG0542	response to heat
XAC3196	COG1116	anion transmembrane transporter activity
XAC3197	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XAC3198	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XAC3199	COG0667	Aldo Keto reductase
XAC3201	COG4771	TonB-dependent receptor
XAC3202	COG2827	Endonuclease containing a URI domain
XAC3209	COG1877	trehalose-phosphatase activity
XAC3210	COG3387	PFAM Glycoside hydrolase 15-related
XAC3213	COG0840	transmembrane signaling receptor activity
XAC3214	COG3011	Protein conserved in bacteria
XAC3217	COG0564	pseudouridine synthase activity
XAC3218	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAC3220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XAC3220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XAC3221	COG2963	transposase activity
XAC3223	COG2801	Transposase and inactivated derivatives
XAC3225	COG2951	lytic endotransglycosylase activity
XAC3226	COG4644	lycopene metabolic process
XAC3230	COG2369	cell adhesion
XAC3235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XAC3236	COG0045	succinate-CoA ligase (ADP-forming) activity
XAC3243	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XAC3244	COG0237	dephospho-CoA kinase activity
XAC3247	COG2963	transposase activity
XAC3249	COG5002	protein histidine kinase activity
XAC3250	COG0745	RESPONSE REGULATOR receiver
XAC3252	COG0189	ligase activity
XAC3253	COG0189	ligase activity
XAC3269	COG2003	Belongs to the UPF0758 family
XAC3273	COG4191	Histidine kinase
XAC3273	COG0784	Response regulator, receiver
XAC3274	COG4191	Histidine kinase
XAC3274	COG0784	Response regulator, receiver
XAC3296	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XAC3302	COG2022	thiamine diphosphate biosynthetic process
XAC3303	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XAC3304	COG0471	metal ion transport
XAC3304	COG3273	potassium ion transport
XAC3308	COG1970	mechanosensitive ion channel activity
XAC3312	COG3250	beta-galactosidase activity
XAC3313	COG4948	Mandelate Racemase Muconate Lactonizing
XAC3316	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XAC3318	COG0308	aminopeptidase N
XAC3320	COG2801	Transposase and inactivated derivatives
XAC3321	COG2963	transposase activity
XAC3326	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XAC3328	COG0529	Catalyzes the synthesis of activated sulfate
XAC3328	COG2895	sulfate adenylyltransferase (ATP) activity
XAC3329	COG0175	sulfate reduction
XAC3330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XAC3331	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XAC3332	COG0175	sulfate reduction
XAC3340	COG1648	precorrin-2 dehydrogenase activity
XAC3340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XAC3343	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
XAC3344	COG3588	fructose-bisphosphate aldolase
XAC3345	COG0469	pyruvate kinase activity
XAC3347	COG0126	phosphoglycerate kinase activity
XAC3352	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XAC3354	COG3047	cAMP biosynthetic process
XAC3355	COG3047	cAMP biosynthetic process
XAC3357	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XAC3357	COG3453	Protein conserved in bacteria
XAC3358	COG0725	ABC transporter, periplasmic molybdate-binding protein
XAC3359	COG4149	molybdate abc transporter
XAC3360	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XAC3367	COG1376	ErfK ybiS ycfS ynhG family protein
XAC3368	COG0739	heme binding
XAC3370	COG4773	Receptor
XAC3371	COG0596	Alpha beta hydrolase
XAC3372	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XAC3373	COG1301	dicarboxylic acid transport
XAC3375	COG2304	oxidoreductase activity
XAC3379	COG0714	Associated with various cellular activities
XAC3386	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XAC3389	COG0254	rRNA binding
XAC3391	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XAC3393	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XAC3394	COG1758	RNA polymerase activity
XAC3395	COG0194	GDP metabolic process
XAC3396	COG1561	YicC-like family, N-terminal region
XAC3397	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XAC3399	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XAC3400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XAC3403	COG0006	proline dipeptidase activity
XAC3405	COG0006	proline dipeptidase activity
XAC3406	COG3079	Belongs to the UPF0149 family
XAC3409	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XAC3411	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XAC3413	COG2912	Transglutaminase-like superfamily
XAC3414	COG1773	rubredoxin
XAC3415	COG0352	thiamine-phosphate diphosphorylase activity
XAC3420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XAC3423	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XAC3429	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XAC3430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XAC3431	COG1028	Short-chain dehydrogenase reductase Sdr
XAC3433	COG0671	phosphoesterase, PA-phosphatase related
XAC3434	COG3781	membrane
XAC3436	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XAC3437	COG0563	adenylate kinase activity
XAC3440	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XAC3442	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XAC3446	COG3710	Transcriptional regulator
XAC3447	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XAC3449	COG0840	transmembrane signaling receptor activity
XAC3450	COG0405	Gamma-glutamyltransferase
XAC3451	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XAC3455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XAC3456	COG0473	3-isopropylmalate dehydrogenase activity
XAC3457	COG0066	3-isopropylmalate dehydratase activity
XAC3458	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XAC3462	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XAC3463	COG1538	Outer membrane efflux protein
XAC3464	COG1519	Transferase
XAC3465	COG1560	Kdo2-lipid A biosynthetic process
XAC3470	COG0281	malic enzyme
XAC3470	COG0280	phosphate acetyltransferase
XAC3471	COG1301	dicarboxylic acid transport
XAC3476	COG0583	DNA-binding transcription factor activity
XAC3477	COG0667	Aldo Keto reductase
XAC3480	COG2197	response regulator
XAC3481	COG1840	ABC-type Fe3 transport system, periplasmic component
XAC3482	COG0642	Histidine kinase
XAC3485	COG2851	Citrate transporter
XAC3486	COG1028	Short-chain dehydrogenase reductase Sdr
XAC3487	COG1609	Transcriptional regulator
XAC3488	COG2211	Major facilitator Superfamily
XAC3493	COG1162	GTPase activity
XAC3498	COG4773	Receptor
XAC3499	COG0726	polysaccharide deacetylase
XAC3500	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XAC3503	COG2963	transposase activity
XAC3504	COG2801	Transposase and inactivated derivatives
XAC3508	COG1307	EDD domain protein, DegV family
XAC3510	COG0242	peptide deformylase activity
XAC3515	COG0457	Tetratricopeptide repeat
XAC3516	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
XAC3517	COG1215	transferase activity, transferring glycosyl groups
XAC3518	COG1215	transferase activity, transferring glycosyl groups
XAC3521	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XAC3532	COG2188	Transcriptional regulator
XAC3534	COG1450	Type ii and iii secretion system protein
XAC3537	COG3166	PFAM Fimbrial assembly family protein
XAC3538	COG3156	type II secretion system protein K
XAC3539	COG4795	General secretion pathway protein
XAC3540	COG2165	general secretion pathway protein
XAC3541	COG4970	Tfp pilus assembly protein FimT
XAC3542	COG2165	general secretion pathway protein
XAC3543	COG1459	type II secretion system
XAC3544	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XAC3545	COG1404	Belongs to the peptidase S8 family
XAC3546	COG5295	Hep Hag repeat protein
XAC3547	COG1404	Belongs to the peptidase S8 family
XAC3548	COG5295	Hep Hag repeat protein
XAC3549	COG0047	phosphoribosylformylglycinamidine synthase activity
XAC3549	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XAC3550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XAC3551	COG4974	Belongs to the 'phage' integrase family
XAC3554	COG0795	lipopolysaccharide-transporting ATPase activity
XAC3556	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XAC3559	COG0525	valine-tRNA ligase activity
XAC3565	COG1183	phosphatidylcholine synthase activity
XAC3567	COG0442	prolyl-tRNA aminoacylation
XAC3570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XAC3571	COG1127	ABC transporter
XAC3572	COG3218	ABC-type transport auxiliary lipoprotein component
XAC3572	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XAC3579	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XAC3580	COG0662	Cupin 2, conserved barrel domain protein
XAC3580	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XAC3586	COG2086	electron transfer activity
XAC3589	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XAC3589	COG0546	phosphoglycolate phosphatase activity
XAC3590	COG0277	FAD linked oxidase domain protein
XAC3593	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XAC3598	COG1216	Glycosyl transferase, family 2
XAC3598	COG0438	transferase activity, transferring glycosyl groups
XAC3602	COG0626	cystathionine gamma-synthase activity
XAC3608	COG0625	glutathione transferase activity
XAC3610	COG0513	Belongs to the DEAD box helicase family
XAC3613	COG4771	TonB-dependent receptor
XAC3614	COG0720	synthase
XAC3616	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XAC3617	COG1956	GAF domain-containing protein
XAC3619	COG2819	hydrolase of the alpha beta superfamily
XAC3622	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XAC3623	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XAC3627	COG0339	signal peptide processing
XAC3630	COG2132	Multicopper oxidase
XAC3637	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XAC3638	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAC3639	COG4591	ABC-type transport system involved in lipoprotein release permease component
XAC3639	COG1136	(ABC) transporter
XAC3640	COG0577	efflux transmembrane transporter activity
XAC3640	COG1136	(ABC) transporter
XAC3641	COG0577	efflux transmembrane transporter activity
XAC3643	COG2204	response regulator
XAC3644	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XAC3648	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XAC3649	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XAC3650	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XAC3651	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XAC3652	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XAC3653	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XAC3655	COG0356	it plays a direct role in the translocation of protons across the membrane
XAC3659	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XAC3661	COG0508	dehydrogenase complex catalyzes the overall conversion of
XAC3668	COG2011	ABC-type metal ion transport system permease component
XAC3669	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XAC3670	COG0697	spore germination
XAC3671	COG1666	GTP binding
XAC3673	COG0784	Response regulator, receiver
XAC3673	COG5002	protein histidine kinase activity
XAC3673	COG2198	Histidine kinase
XAC3677	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XAC3678	COG1187	pseudouridine synthase activity
XAC3679	COG2813	Specifically methylates the guanine in position
XAC3683	COG2205	protein histidine kinase activity
XAC3683	COG2202	Pas domain
XAC3687	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XAC3688	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XAC3689	COG1522	sequence-specific DNA binding
XAC3699	COG0842	Transport permease protein
XAC3700	COG1131	(ABC) transporter
XAC3701	COG0025	NhaP-type Na H and K H
XAC3703	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XAC3704	COG1573	uracil-dna glycosylase
XAC3706	COG3384	dioxygenase
XAC3708	COG0583	DNA-binding transcription factor activity
XAC3710	COG0667	Aldo Keto reductase
XAC3712	COG3590	peptidase
XAC3717	COG0531	amino acid
XAC3720	COG2972	Histidine kinase
XAC3725	COG3685	Protein conserved in bacteria
XAC3726	COG3546	catalase activity
XAC3733	COG2204	response regulator
XAC3735	COG1271	oxidase subunit
XAC3736	COG1294	oxidase, subunit
XAC3738	COG1028	Short-chain dehydrogenase reductase Sdr
XAC3740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XAC3744	COG1132	(ABC) transporter
XAC3747	COG1063	alcohol dehydrogenase
XAC3762	COG0251	oxidation-reduction process
XAC3768	COG0840	transmembrane signaling receptor activity
XAC3773	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XAC3782	COG0024	Methionine aminopeptidase
XAC3788	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XAC3789	COG1490	D-aminoacyl-tRNA deacylase activity
XAC3790	COG1560	Kdo2-lipid A biosynthetic process
XAC3799	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XAC3799	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XAC3800	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XAC3801	COG0242	peptide deformylase activity
XAC3802	COG1652	LysM domain
XAC3803	COG0758	DNA mediated transformation
XAC3804	COG2922	Belongs to the Smg family
XAC3807	COG1754	DNA topoisomerase type I activity
XAC3807	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XAC3808	COG0009	L-threonylcarbamoyladenylate synthase
XAC3811	COG1028	Short-chain dehydrogenase reductase Sdr
XAC3813	COG0616	signal peptide processing
XAC3814	COG0534	Mate efflux family protein
XAC3818	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XAC3819	COG0625	glutathione transferase activity
XAC3822	COG1252	NADH dehydrogenase
XAC3823	COG2860	membrane
XAC3824	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XAC3825	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XAC3826	COG3437	response regulator, receiver
XAC3827	COG2177	Part of the ABC transporter FtsEX involved in
XAC3828	COG2884	Cell division ATP-binding protein ftsE
XAC3829	COG0513	Belongs to the DEAD box helicase family
XAC3830	COG3118	belongs to the thioredoxin family
XAC3831	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XAC3832	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XAC3833	COG0583	DNA-binding transcription factor activity
XAC3842	COG1518	maintenance of DNA repeat elements
XAC3843	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
XAC3845	COG1652	LysM domain
XAC3846	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XAC3846	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XAC3847	COG1473	amidohydrolase
XAC3848	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAC3849	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XAC3851	COG5383	Protein conserved in bacteria
XAC3859	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
XAC3860	COG3023	N-Acetylmuramoyl-L-alanine amidase
XAC3862	COG4948	Mandelate Racemase Muconate Lactonizing
XAC3864	COG0531	amino acid
XAC3867	COG4682	membrane
XAC3868	COG2133	pyrroloquinoline quinone binding
XAC3870	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XAC3871	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XAC3872	COG0828	Belongs to the bacterial ribosomal protein bS21 family
XAC3873	COG1610	YqeY-like protein
XAC3875	COG1295	ribonuclease BN
XAC3876	COG0358	DNA primase activity
XAC3879	COG0109	protoheme IX farnesyltransferase activity
XAC3885	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XAC3888	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XAC3897	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XAC3898	COG0739	heme binding
XAC3899	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XAC3901	COG2211	Major facilitator Superfamily
XAC3902	COG0708	Exodeoxyribonuclease III
XAC3903	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XAC3905	COG1192	Involved in chromosome partitioning
XAC3906	COG1475	DNA binding
XAC3909	COG0463	Glycosyl transferase, family 2
XAC3913	COG0756	dUTP diphosphatase activity
XAC3914	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XAC3915	COG2003	Belongs to the UPF0758 family
XAC3916	COG0018	arginyl-trna synthetase
XAC3919	COG4221	oxidoreductase activity
XAC3920	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XAC3920	COG2755	lipolytic protein G-D-S-L family
XAC3922	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XAC3923	COG1166	arginine decarboxylase activity
XAC3924	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XAC3931	COG0606	chelatase, subunit chli
XAC3945	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XAC3955	COG0606	chelatase, subunit chli
XAC3958	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XAC3965	COG1690	Belongs to the RtcB family
XAC3973	COG1090	epimerase
XAC3974	COG0745	RESPONSE REGULATOR receiver
XAC3975	COG0642	Histidine kinase
XAC3980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XAC3986	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XAC3987	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XAC3990	COG0753	catalase activity
XAC3993	COG2197	response regulator
XAC3994	COG4585	Histidine kinase
XAC3995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAC3996	COG1136	(ABC) transporter
XAC4000	COG2962	Rard protein
XAC4003	COG0697	spore germination
XAC4005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XAC4006	COG0180	Tryptophanyl-tRNA synthetase
XAC4007	COG3237	CsbD-like
XAC4014	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XAC4017	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XAC4022	COG2205	protein histidine kinase activity
XAC4023	COG0745	RESPONSE REGULATOR receiver
XAC4025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XAC4031	COG1199	ATP-dependent helicase activity
XAC4034	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XAC4047	COG0625	glutathione transferase activity
XAC4054	COG4555	ABC transporter
XAC4056	COG1476	TRANSCRIPTIONal
XAC4065	COG1131	(ABC) transporter
XAC4066	COG0633	Ferredoxin
XAC4066	COG0543	2 iron, 2 sulfur cluster binding
XAC4067	COG0842	Transport permease protein
XAC4068	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XAC4074	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XAC4075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XAC4077	COG1042	CoA-binding domain protein
XAC4077	COG0045	succinate-CoA ligase (ADP-forming) activity
XAC4077	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XAC4078	COG2239	Acts as a magnesium transporter
XAC4079	COG3338	carbonate dehydratase activity
XAC4081	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XAC4082	COG3387	PFAM Glycoside hydrolase 15-related
XAC4085	COG3100	YcgL domain-containing protein
XAC4086	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XAC4088	COG0463	Glycosyl transferase, family 2
XAC4090	COG1028	Short-chain dehydrogenase reductase Sdr
XAC4098	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XAC4101	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XAC4106	COG4946	Tricorn protease homolog
XAC4106	COG1506	peptidase
XAC4106	COG0823	Involved in the tonB-independent uptake of proteins
XAC4109	COG0408	coproporphyrinogen oxidase activity
XAC4116	COG2815	serine threonine protein kinase
XAC4116	COG0515	serine threonine protein kinase
XAC4117	COG0631	protein serine/threonine phosphatase activity
XAC4124	COG3501	Rhs element vgr protein
XAC4151	COG0210	DNA helicase
XAC4153	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAC4154	COG0583	DNA-binding transcription factor activity
XAC4155	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XAC4157	COG2159	amidohydrolase
XAC4158	COG0267	Belongs to the bacterial ribosomal protein bL33 family
XAC4159	COG0227	Belongs to the bacterial ribosomal protein bL28 family
XAC4161	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XAC4165	COG0357	Ribosomal RNA small subunit methyltransferase G
XAC4166	COG3540	Alkaline phosphatase
XAC4168	COG2091	lysine biosynthetic process via aminoadipic acid
XAC4171	COG0708	Exodeoxyribonuclease III
XAC4172	COG1846	Transcriptional regulator
XAC4172	COG1940	carbohydrate kinase activity
XAC4174	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XAC4176	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XAC4177	COG3162	membrane
XAC4179	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XAC4183	COG3507	Belongs to the glycosyl hydrolase 43 family
XAC4186	COG1028	Short-chain dehydrogenase reductase Sdr
XAC4187	COG0179	Fumarylacetoacetate (FAA) hydrolase
XAC4188	COG4948	Mandelate Racemase Muconate Lactonizing
XAC4189	COG3254	rhamnose metabolic process
XAC4190	COG0738	Major facilitator superfamily
XAC4191	COG1414	Transcriptional regulator
XAC4192	COG1971	Probably functions as a manganese efflux pump
XAC4193	COG2205	protein histidine kinase activity
XAC4195	COG3459	Glycosyltransferase 36 associated
XAC4196	COG2211	Major facilitator Superfamily
XAC4197	COG3265	gluconokinase activity
XAC4199	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XAC4203	COG2911	Protein conserved in bacteria
XAC4204	COG0729	surface antigen
XAC4207	COG2963	transposase activity
XAC4208	COG2801	Transposase and inactivated derivatives
XAC4211	COG0752	glycyl-tRNA synthetase alpha subunit
XAC4212	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XAC4214	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XAC4214	COG0519	Catalyzes the synthesis of GMP from XMP
XAC4216	COG0805	protein transport
XAC4217	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XAC4218	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XAC4220	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XAC4223	COG2974	May be involved in recombination
XAC4224	COG0037	tRNA processing
XAC4225	COG2115	Belongs to the xylose isomerase family
XAC4227	COG3661	Belongs to the glycosyl hydrolase 67 family
XAC4229	COG4948	Mandelate Racemase Muconate Lactonizing
XAC4231	COG1472	Belongs to the glycosyl hydrolase 3 family
XAC4232	COG0246	Mannitol dehydrogenase
XAC4241	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XAC4242	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XAC4248	COG3386	PFAM SMP-30 Gluconolaconase
XAC4250	COG3250	beta-galactosidase activity
XAC4251	COG1904	glucuronate isomerase
XAC4252	COG3693	PFAM glycoside hydrolase, family 10
XAC4254	COG3693	PFAM glycoside hydrolase, family 10
XAC4257	COG2211	Major facilitator Superfamily
XAC4270	COG2937	Belongs to the GPAT DAPAT family
XAC4276	COG0284	orotidine-5'-phosphate decarboxylase activity
XAC4277	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
XAC4278	COG3132	Protein of unknown function, DUF480
XAC4281	COG0210	DNA helicase
XAC4282	COG1435	thymidine kinase activity
XAC4284	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XAC4286	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XAC4292	COG3135	benzoate transporter
XAC4296	COG0676	glucose-6-phosphate 1-epimerase activity
XAC4297	COG3012	SEC-C Motif Domain Protein
XAC4298	COG0730	response to heat
XAC4302	COG0302	gtp cyclohydrolase
XAC4305	COG1566	PFAM secretion protein HlyD family protein
XAC4307	COG1289	transmembrane transporter activity
XAC4308	COG0477	Major facilitator Superfamily
XAC4310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XAC4314	COG4691	Plasmid stability protein
XAC4315	COG1487	ribonuclease activity
XAC4320	COG0564	pseudouridine synthase activity
XAC4322	COG2963	transposase activity
XAC4323	COG2801	Transposase and inactivated derivatives
XAC4326	COG0439	Biotin carboxylase
XAC4336	COG1074	ATP-dependent DNA helicase activity
XAC4337	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XAC4339	COG1127	ABC transporter
XAC4340	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XAC4341	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XAC4344	COG2853	Lipoprotein
XAC4346	COG0386	Belongs to the glutathione peroxidase family
XAC4348	COG1322	Protein conserved in bacteria
XAC4349	COG0604	alcohol dehydrogenase
XAC4350	COG0583	DNA-binding transcription factor activity
XAC4352	COG0625	glutathione transferase activity
XAC4354	COG0531	amino acid
XAC4355	COG3537	Alpha-1,2-mannosidase
XAC4358	COG3706	GGDEF domain
XAC4359	COG3835	regulator
XAC4360	COG1929	Belongs to the glycerate kinase type-1 family
XAC4361	COG2271	Major facilitator Superfamily
XAC4364	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XAC4365	COG0861	Integral membrane protein TerC family
XAC4367	COG0584	glycerophosphoryl diester phosphodiesterase
XAC4370	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XAC4371	COG0726	polysaccharide deacetylase
XAC4372	COG0706	membrane insertase activity
XAC4373	COG0594	ribonuclease P activity
XAC4374	COG0230	Belongs to the bacterial ribosomal protein bL34 family
XACa0006	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XACa0032	COG3318	Belongs to the UPF0149 family
XACa0032	COG3012	SEC-C Motif Domain Protein
XACa0038	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XACa0041	COG1192	Involved in chromosome partitioning
XACb0007	COG2951	lytic endotransglycosylase activity
XACb0008	COG4644	lycopene metabolic process
XACb0038	COG2948	multi-organism process
XACb0039	COG3504	Conjugal transfer protein
XACb0060	COG4456	Virulence-associated protein
XACb0061	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XACb0062	COG2801	Transposase and inactivated derivatives
XACb0071	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs