locus-tag	class	description
Xdur_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Xdur_000015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Xdur_000020	COG0187	DNA topoisomerase II activity
Xdur_000030	COG0501	Belongs to the peptidase M48B family
Xdur_000060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Xdur_000070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Xdur_000115	COG0793	Belongs to the peptidase S41A family
Xdur_000120	COG4942	peptidase
Xdur_000130	COG2234	aminopeptidase activity
Xdur_000140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Xdur_000150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Xdur_000160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Xdur_000165	COG1064	alcohol dehydrogenase
Xdur_000175	COG0493	'glutamate synthase
Xdur_000180	COG0067	glutamate synthase
Xdur_000180	COG0069	glutamate synthase activity
Xdur_000180	COG0070	glutamate synthase
Xdur_000230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Xdur_000245	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Xdur_000250	COG0297	glycogen (starch) synthase activity
Xdur_000250	COG0438	transferase activity, transferring glycosyl groups
Xdur_000270	COG0367	asparagine synthase
Xdur_000300	COG1132	(ABC) transporter
Xdur_000330	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Xdur_000415	COG1111	helicase
Xdur_000415	COG1205	dead DEAH box helicase
Xdur_000420	COG1272	protein, Hemolysin III
Xdur_000440	COG0300	oxidoreductase activity
Xdur_000445	COG1028	Short-chain dehydrogenase reductase Sdr
Xdur_000465	COG2249	NAD(P)H dehydrogenase (quinone) activity
Xdur_000555	COG3237	CsbD-like
Xdur_000600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Xdur_000605	COG0477	Major facilitator Superfamily
Xdur_000645	COG0714	Associated with various cellular activities
Xdur_000675	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Xdur_000685	COG4772	TonB-dependent receptor
Xdur_000695	COG0662	Cupin 2, conserved barrel domain protein
Xdur_000705	COG1012	belongs to the aldehyde dehydrogenase family
Xdur_000730	COG1304	FMN binding
Xdur_000740	COG4585	Histidine kinase
Xdur_000745	COG2197	response regulator
Xdur_000765	COG3710	Transcriptional regulator
Xdur_000770	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Xdur_000860	COG0366	Alpha amylase catalytic
Xdur_000865	COG0366	Alpha amylase catalytic
Xdur_000870	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Xdur_000890	COG2755	lipolytic protein G-D-S-L family
Xdur_000890	COG0657	acetylesterase activity
Xdur_000900	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Xdur_000915	COG3507	Belongs to the glycosyl hydrolase 43 family
Xdur_000920	COG1609	Transcriptional regulator
Xdur_000925	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Xdur_000930	COG1028	Short-chain dehydrogenase reductase Sdr
Xdur_000940	COG2755	lipolytic protein G-D-S-L family
Xdur_000955	COG3186	Phenylalanine-4-hydroxylase
Xdur_000960	COG1522	sequence-specific DNA binding
Xdur_000970	COG1752	Esterase of the alpha-beta hydrolase superfamily
Xdur_000980	COG1119	ATPase activity
Xdur_001020	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Xdur_001040	COG1396	sequence-specific DNA binding
Xdur_001060	COG0489	protein tyrosine kinase activity
Xdur_001065	COG2062	phosphohistidine phosphatase, SixA
Xdur_001075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Xdur_001120	COG1968	undecaprenyl-diphosphatase activity
Xdur_001125	COG0174	glutamine synthetase
Xdur_001130	COG0347	Belongs to the P(II) protein family
Xdur_001135	COG0004	ammonium transporteR
Xdur_001140	COG3852	Histidine kinase
Xdur_001145	COG2204	response regulator
Xdur_001150	COG2032	superoxide dismutase activity
Xdur_001155	COG2032	superoxide dismutase activity
Xdur_001165	COG0346	lactoylglutathione lyase activity
Xdur_001175	COG0183	Belongs to the thiolase family
Xdur_001210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Xdur_001215	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Xdur_001220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Xdur_001235	COG0028	Belongs to the TPP enzyme family
Xdur_001240	COG2205	protein histidine kinase activity
Xdur_001265	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Xdur_001280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Xdur_001290	COG0596	Alpha beta hydrolase
Xdur_001295	COG0727	PFAM Uncharacterised protein family (UPF0153)
Xdur_001300	COG0318	PFAM AMP-dependent synthetase and ligase
Xdur_001305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Xdur_001315	COG1181	Belongs to the D-alanine--D-alanine ligase family
Xdur_001325	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Xdur_001360	COG0339	signal peptide processing
Xdur_001390	COG0475	glutathione-regulated potassium exporter activity
Xdur_001395	COG0583	DNA-binding transcription factor activity
Xdur_001400	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Xdur_001405	COG2224	Isocitrate lyase
Xdur_001435	COG4770	biotin carboxylase activity
Xdur_001440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Xdur_001500	COG0523	cobalamin synthesis protein
Xdur_001510	COG0697	spore germination
Xdur_001520	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Xdur_001525	COG1846	Transcriptional regulator
Xdur_001530	COG1764	response to oxidative stress
Xdur_001555	COG2130	NADP-dependent
Xdur_001570	COG1187	pseudouridine synthase activity
Xdur_001585	COG1643	Atp-dependent helicase
Xdur_001590	COG4807	Protein conserved in bacteria
Xdur_001595	COG2351	hydroxyisourate hydrolase activity
Xdur_001600	COG2072	flavoprotein involved in K transport
Xdur_001620	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Xdur_001655	COG1957	nucleoside hydrolase
Xdur_001665	COG2252	PERMEase
Xdur_001685	COG0084	hydrolase, TatD family'
Xdur_001700	COG0583	DNA-binding transcription factor activity
Xdur_001705	COG2814	Major facilitator Superfamily
Xdur_001720	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Xdur_001725	COG1902	pentaerythritol trinitrate reductase activity
Xdur_001745	COG0745	RESPONSE REGULATOR receiver
Xdur_001750	COG2205	protein histidine kinase activity
Xdur_001755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xdur_001775	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Xdur_001780	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Xdur_001785	COG0583	DNA-binding transcription factor activity
Xdur_001815	COG0702	epimerase
Xdur_001820	COG1733	regulation of RNA biosynthetic process
Xdur_001850	COG0129	dihydroxy-acid dehydratase activity
Xdur_001865	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Xdur_001920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Xdur_001925	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Xdur_001950	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Xdur_001955	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Xdur_001965	COG3485	protocatechuate 3,4-dioxygenase
Xdur_001970	COG3485	protocatechuate 3,4-dioxygenase
Xdur_001980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Xdur_001985	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Xdur_001995	COG1414	Transcriptional regulator
Xdur_002005	COG0657	acetylesterase activity
Xdur_002015	COG0445	tRNA wobble uridine modification
Xdur_002025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Xdur_002055	COG2267	carboxylic ester hydrolase activity
Xdur_002065	COG0156	8-amino-7-oxononanoate synthase activity
Xdur_002070	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Xdur_002075	COG1040	competence protein
Xdur_002080	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Xdur_002160	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Xdur_002230	COG3264	Mechanosensitive ion channel
Xdur_002230	COG1511	domain protein
Xdur_002235	COG1368	sulfuric ester hydrolase activity
Xdur_002240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Xdur_002245	COG2354	Protein conserved in bacteria
Xdur_002255	COG0297	glycogen (starch) synthase activity
Xdur_002260	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Xdur_002265	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Xdur_002290	COG0702	epimerase
Xdur_002295	COG1028	Short-chain dehydrogenase reductase Sdr
Xdur_002325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Xdur_002330	COG1028	Short-chain dehydrogenase reductase Sdr
Xdur_002340	COG0513	Belongs to the DEAD box helicase family
Xdur_002345	COG0508	dehydrogenase complex catalyzes the overall conversion of
Xdur_002360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Xdur_002370	COG3483	tryptophan 2,3-dioxygenase activity
Xdur_002375	COG3104	oligopeptide transport
Xdur_002400	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
Xdur_002415	COG1320	monovalent cation:proton antiporter activity
Xdur_002420	COG2212	antiporter activity
Xdur_002430	COG0651	ATP synthesis coupled electron transport
Xdur_002435	COG1006	Multisubunit Na H antiporter MnhC subunit
Xdur_002440	COG2111	Na H antiporter
Xdur_002440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Xdur_002460	COG3179	chitinase
Xdur_002480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Xdur_002485	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Xdur_002500	COG0456	acetyltransferase
Xdur_002505	COG1597	lipid kinase activity
Xdur_002530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Xdur_002535	COG0134	indole-3-glycerol-phosphate synthase activity
Xdur_002545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Xdur_002550	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Xdur_002560	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Xdur_002570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Xdur_002585	COG1051	belongs to the nudix hydrolase family
Xdur_002625	COG0316	Belongs to the HesB IscA family
Xdur_002640	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Xdur_002660	COG2814	Major facilitator Superfamily
Xdur_002665	COG0583	DNA-binding transcription factor activity
Xdur_002670	COG2814	Major facilitator Superfamily
Xdur_002675	COG1289	transmembrane transporter activity
Xdur_002685	COG0151	Belongs to the GarS family
Xdur_002695	COG0138	bifunctional purine biosynthesis protein purh
Xdur_002700	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Xdur_002705	COG2267	carboxylic ester hydrolase activity
Xdur_002710	COG2453	phosphatase
Xdur_002710	COG0671	phosphoesterase, PA-phosphatase related
Xdur_002735	COG4589	Belongs to the CDS family
Xdur_002740	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Xdur_002760	COG2264	protein methyltransferase activity
Xdur_002775	COG0439	Biotin carboxylase
Xdur_002785	COG0511	ligase activity, forming carbon-carbon bonds
Xdur_002790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Xdur_002800	COG1324	tolerance protein
Xdur_002825	COG0300	oxidoreductase activity
Xdur_002830	COG2356	endonuclease I
Xdur_002845	COG0459	protein refolding
Xdur_002860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Xdur_002875	COG3386	PFAM SMP-30 Gluconolaconase
Xdur_002885	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Xdur_002890	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Xdur_002905	COG0778	Nitroreductase
Xdur_002910	COG2353	YceI-like domain
Xdur_002940	COG3052	prosthetic group binding
Xdur_002965	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Xdur_002975	COG1802	Transcriptional regulator
Xdur_003030	COG4221	oxidoreductase activity
Xdur_003045	COG4221	oxidoreductase activity
Xdur_003055	COG0435	Glutathione S-transferase
Xdur_003080	COG2409	Drug exporters of the RND superfamily
Xdur_003085	COG1506	peptidase
Xdur_003085	COG0823	Involved in the tonB-independent uptake of proteins
Xdur_003125	COG0697	spore germination
Xdur_003140	COG1113	amino acid transport
Xdur_003160	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
Xdur_003195	COG5001	Diguanylate cyclase
Xdur_003200	COG0840	transmembrane signaling receptor activity
Xdur_003205	COG5297	Belongs to the glycosyl hydrolase family 6
Xdur_003205	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Xdur_003210	COG0659	secondary active sulfate transmembrane transporter activity
Xdur_003225	COG2943	transferase activity, transferring hexosyl groups
Xdur_003245	COG0181	hydroxymethylbilane synthase activity
Xdur_003270	COG1505	serine-type exopeptidase activity
Xdur_003275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Xdur_003280	COG0436	Aminotransferase
Xdur_003290	COG2832	Protein of unknown function (DUF454)
Xdur_003300	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Xdur_003310	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Xdur_003315	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Xdur_003320	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Xdur_003345	COG2226	methyltransferase
Xdur_003350	COG3300	MHYT domain
Xdur_003350	COG5001	Diguanylate cyclase
Xdur_003355	COG0308	aminopeptidase N
Xdur_003400	COG3284	Transcriptional regulator
Xdur_003405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Xdur_003410	COG1077	Cell shape determining protein MreB Mrl
Xdur_003415	COG1792	Involved in formation and maintenance of cell shape
Xdur_003430	COG0772	Belongs to the SEDS family
Xdur_003440	COG2951	lytic endotransglycosylase activity
Xdur_003445	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Xdur_003450	COG1686	Belongs to the peptidase S11 family
Xdur_003460	COG2921	Belongs to the UPF0250 family
Xdur_003465	COG0321	lipoyl(octanoyl) transferase activity
Xdur_003470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Xdur_003485	COG0583	DNA-binding transcription factor activity
Xdur_003495	COG1051	belongs to the nudix hydrolase family
Xdur_003495	COG1056	cytidyltransferase-related domain
Xdur_003530	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Xdur_003535	COG0673	inositol 2-dehydrogenase activity
Xdur_003540	COG2823	Periplasmic or secreted lipoprotein
Xdur_003545	COG4251	negative regulation of phosphorylation
Xdur_003550	COG0784	Response regulator, receiver
Xdur_003555	COG4191	Histidine kinase
Xdur_003560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Xdur_003615	COG1459	type II secretion system
Xdur_003665	COG3250	beta-galactosidase activity
Xdur_003680	COG2188	Transcriptional regulator
Xdur_003690	COG1609	Transcriptional regulator
Xdur_003695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Xdur_003700	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Xdur_003710	COG0617	tRNA 3'-terminal CCA addition
Xdur_003715	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Xdur_003720	COG1012	belongs to the aldehyde dehydrogenase family
Xdur_003725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Xdur_003740	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Xdur_003755	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Xdur_003760	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Xdur_003775	COG2205	protein histidine kinase activity
Xdur_003805	COG3791	Glutathione-dependent formaldehyde-activating
Xdur_003820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Xdur_003830	COG0697	spore germination
Xdur_003840	COG0488	(ABC) transporter
Xdur_003850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Xdur_003855	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Xdur_003865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Xdur_003865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Xdur_003885	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Xdur_003890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Xdur_003895	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Xdur_003915	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Xdur_003920	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Xdur_003925	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Xdur_003930	COG2205	protein histidine kinase activity
Xdur_003935	COG0745	RESPONSE REGULATOR receiver
Xdur_003950	COG0277	FAD linked oxidase domain protein
Xdur_003955	COG1988	membrane-bound metal-dependent
Xdur_003960	COG0792	nuclease activity
Xdur_003995	COG0275	rRNA processing
Xdur_004000	COG3116	cell division
Xdur_004010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Xdur_004015	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Xdur_004020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Xdur_004030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Xdur_004035	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Xdur_004040	COG1181	Belongs to the D-alanine--D-alanine ligase family
Xdur_004045	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Xdur_004060	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Xdur_004070	COG0739	heme binding
Xdur_004075	COG0653	protein targeting
Xdur_004080	COG0494	nUDIX hydrolase
Xdur_004090	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Xdur_004100	COG0604	alcohol dehydrogenase
Xdur_004100	COG3321	synthase
Xdur_004100	COG1028	Short-chain dehydrogenase reductase Sdr
Xdur_004115	COG0366	Alpha amylase catalytic
Xdur_004145	COG2226	methyltransferase
Xdur_004150	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Xdur_004160	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Xdur_004200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Xdur_004210	COG4106	trans-aconitate 2-methyltransferase activity
Xdur_004215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Xdur_004225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Xdur_004230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Xdur_004235	COG0667	Aldo Keto reductase
Xdur_004245	COG4771	TonB-dependent receptor
Xdur_004265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Xdur_004270	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Xdur_004280	COG2175	clavaminate synthase activity
Xdur_004290	COG4181	ATPase activity
Xdur_004305	COG0642	Histidine kinase
Xdur_004315	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Xdur_004335	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Xdur_004340	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Xdur_004355	COG3829	transcription factor binding
Xdur_004365	COG1116	anion transmembrane transporter activity
Xdur_004370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Xdur_004380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Xdur_004385	COG0431	NADPH-dependent FMN reductase
Xdur_004410	COG0747	negative chemotaxis
Xdur_004420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Xdur_004430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Xdur_004435	COG2967	ApaG domain
Xdur_004440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Xdur_004445	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Xdur_004450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Xdur_004455	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Xdur_004470	COG0123	including yeast histone deacetylase and acetoin utilization protein
Xdur_004475	COG2096	Adenosyltransferase
Xdur_004485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Xdur_004490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Xdur_004520	COG3384	dioxygenase
Xdur_004525	COG0583	DNA-binding transcription factor activity
Xdur_004540	COG1024	Enoyl-CoA hydratase
Xdur_004560	COG3386	PFAM SMP-30 Gluconolaconase
Xdur_004575	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Xdur_004600	COG0697	spore germination
Xdur_004605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Xdur_004625	COG0784	Response regulator, receiver
Xdur_004625	COG5002	protein histidine kinase activity
Xdur_004625	COG2205	protein histidine kinase activity
Xdur_004630	COG2197	response regulator
Xdur_004640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Xdur_004650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Xdur_004655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Xdur_004660	COG0583	DNA-binding transcription factor activity
Xdur_004665	COG3634	alkyl hydroperoxide reductase activity
Xdur_004675	COG2890	protein-(glutamine-N5) methyltransferase activity
Xdur_004695	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Xdur_004695	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Xdur_004725	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Xdur_004750	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Xdur_004765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Xdur_004770	COG1404	Belongs to the peptidase S8 family
Xdur_004775	COG1404	Belongs to the peptidase S8 family
Xdur_004780	COG1404	Belongs to the peptidase S8 family
Xdur_004785	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Xdur_004810	COG1295	ribonuclease BN
Xdur_004815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Xdur_004820	COG1254	Belongs to the acylphosphatase family
Xdur_004835	COG0521	Mo-molybdopterin cofactor biosynthetic process
Xdur_004845	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Xdur_004850	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Xdur_004860	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
Xdur_004865	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Xdur_004875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Xdur_004880	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Xdur_004885	COG0193	aminoacyl-tRNA hydrolase activity
Xdur_004890	COG0012	GTP binding
Xdur_004910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Xdur_004925	COG0250	Participates in transcription elongation, termination and antitermination
Xdur_004930	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Xdur_004935	COG0081	regulation of translation
Xdur_004940	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Xdur_004945	COG0222	ribosome binding
Xdur_004950	COG0085	RNA polymerase activity
Xdur_004955	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Xdur_004960	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Xdur_004965	COG0049	tRNA binding
Xdur_004970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Xdur_004975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Xdur_004980	COG0051	transcription antitermination factor activity, RNA binding
Xdur_004985	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Xdur_004990	COG0088	Forms part of the polypeptide exit tunnel
Xdur_004995	COG0089	rRNA binding
Xdur_005000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Xdur_005005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Xdur_005015	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Xdur_005020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Xdur_005025	COG0255	Belongs to the universal ribosomal protein uL29 family
Xdur_005030	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Xdur_005040	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Xdur_005045	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Xdur_005055	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Xdur_005060	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Xdur_005065	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Xdur_005075	COG1841	ribosomal large subunit assembly
Xdur_005080	COG0200	Binds to the 23S rRNA
Xdur_005085	COG0201	protein transport
Xdur_005110	COG0203	ribosomal protein L17
Xdur_005115	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Xdur_005130	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Xdur_005140	COG0154	amidase activity
Xdur_005150	COG1217	gtp-binding protein TYPA
Xdur_005155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Xdur_005160	COG0039	L-malate dehydrogenase activity
Xdur_005165	COG0625	glutathione transferase activity
Xdur_005175	COG1902	pentaerythritol trinitrate reductase activity
Xdur_005175	COG0446	pyridine nucleotide-disulphide oxidoreductase
Xdur_005180	COG0604	alcohol dehydrogenase
Xdur_005205	COG0156	8-amino-7-oxononanoate synthase activity
Xdur_005210	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Xdur_005215	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Xdur_005220	COG4208	sulfate ABC transporter
Xdur_005225	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Xdur_005235	COG1063	alcohol dehydrogenase
Xdur_005265	COG0406	alpha-ribazole phosphatase activity
Xdur_005270	COG0285	dihydrofolate synthase activity
Xdur_005290	COG2833	Protein of unknown function (DUF455)
Xdur_005295	COG3291	Pkd domain containing protein
Xdur_005305	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Xdur_005310	COG0671	phosphoesterase, PA-phosphatase related
Xdur_005315	COG0438	transferase activity, transferring glycosyl groups
Xdur_005325	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Xdur_005340	COG4783	chaperone-mediated protein folding
Xdur_005355	COG0473	3-isopropylmalate dehydrogenase activity
Xdur_005500	COG2801	Transposase and inactivated derivatives
Xdur_005525	COG0544	peptidyl-prolyl cis-trans isomerase activity
Xdur_005535	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Xdur_005565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Xdur_005575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Xdur_005585	COG0328	RNA-DNA hybrid ribonuclease activity
Xdur_005590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Xdur_005595	COG0631	protein serine/threonine phosphatase activity
Xdur_005610	COG0859	PFAM glycosyl transferase family 9
Xdur_005615	COG3642	lipopolysaccharide core region biosynthetic process
Xdur_005620	COG1234	tRNA 3'-trailer cleavage
Xdur_005625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Xdur_005635	COG0315	cyclic pyranopterin monophosphate synthase activity
Xdur_005640	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Xdur_005645	COG0314	molybdopterin synthase activity
Xdur_005730	COG2003	Belongs to the UPF0758 family
Xdur_005750	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Xdur_005810	COG0210	DNA helicase
Xdur_005855	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Xdur_005860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Xdur_005865	COG0537	adenosine 5'-monophosphoramidase activity
Xdur_005885	COG0714	Associated with various cellular activities
Xdur_005905	COG0424	maF-like protein
Xdur_005910	COG1399	metal-binding, possibly nucleic acid-binding protein
Xdur_005915	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Xdur_005920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Xdur_005935	COG1028	Short-chain dehydrogenase reductase Sdr
Xdur_005950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Xdur_005955	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Xdur_005980	COG3829	transcription factor binding
Xdur_006000	COG3609	addiction module antidote protein, CC2985 family
Xdur_006030	COG2373	Large extracellular alpha-helical protein
Xdur_006045	COG4953	penicillin-binding protein 1C
Xdur_006065	COG0678	peroxiredoxin activity
Xdur_006085	COG0330	HflC and HflK could
Xdur_006090	COG0330	HflC and HflK could
Xdur_006100	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Xdur_006105	COG0308	aminopeptidase N
Xdur_006110	COG1028	Short-chain dehydrogenase reductase Sdr
Xdur_006115	COG1309	transcriptional regulator
Xdur_006160	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Xdur_006190	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Xdur_006200	COG3387	PFAM Glycoside hydrolase 15-related
Xdur_006205	COG1028	Short-chain dehydrogenase reductase Sdr
Xdur_006210	COG3537	Alpha-1,2-mannosidase
Xdur_006230	COG0492	ferredoxin-NADP+ reductase activity
Xdur_006260	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Xdur_006265	COG2080	2 iron, 2 sulfur cluster binding
Xdur_006300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Xdur_006315	COG0587	DNA-directed DNA polymerase activity
Xdur_006335	COG1297	OPT oligopeptide transporter protein
Xdur_006350	COG0823	Involved in the tonB-independent uptake of proteins
Xdur_006350	COG1506	peptidase
Xdur_006365	COG1917	Cupin 2, conserved barrel domain protein
Xdur_006365	COG2207	Transcriptional regulator
Xdur_006380	COG0753	catalase activity
Xdur_006385	COG0656	L-ascorbic acid biosynthetic process
Xdur_006395	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Xdur_006395	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Xdur_006400	COG2814	Major facilitator Superfamily
Xdur_006415	COG2194	sulfuric ester hydrolase activity
Xdur_006430	COG0745	RESPONSE REGULATOR receiver
Xdur_006435	COG0642	Histidine kinase
Xdur_006445	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Xdur_006450	COG2894	cell division
Xdur_006455	COG0850	regulation of cytokinetic process
Xdur_006465	COG4585	Histidine kinase
Xdur_006470	COG2197	response regulator
Xdur_006485	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Xdur_006510	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Xdur_006520	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Xdur_006540	COG1946	Acyl-CoA thioesterase
Xdur_006555	COG0824	Thioesterase
Xdur_006560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Xdur_006565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Xdur_006570	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Xdur_006575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Xdur_006580	COG0268	Binds directly to 16S ribosomal RNA
Xdur_006590	COG0196	riboflavin kinase activity
Xdur_006595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Xdur_006600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Xdur_006605	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Xdur_006620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Xdur_006625	COG1845	cytochrome c oxidase, subunit III
Xdur_006630	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Xdur_006645	COG3152	Membrane
Xdur_006655	COG2207	Transcriptional regulator
Xdur_006660	COG0326	Molecular chaperone. Has ATPase activity
Xdur_006670	COG1366	Belongs to the anti-sigma-factor antagonist family
Xdur_006675	COG1366	Belongs to the anti-sigma-factor antagonist family
Xdur_006680	COG2172	sigma factor antagonist activity
Xdur_006705	COG4771	TonB-dependent receptor
Xdur_006715	COG5507	3-demethylubiquinone-9 3-methyltransferase
Xdur_006720	COG2205	protein histidine kinase activity
Xdur_006730	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Xdur_006735	COG2205	protein histidine kinase activity
Xdur_006735	COG3437	response regulator, receiver
Xdur_006735	COG3850	Histidine kinase
Xdur_006735	COG4999	Histidine kinase
Xdur_006740	COG0784	Response regulator, receiver
Xdur_006740	COG4191	Histidine kinase
Xdur_006770	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Xdur_006775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Xdur_006785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Xdur_006790	COG0228	four-way junction DNA binding
Xdur_006795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Xdur_006800	COG0336	Belongs to the RNA methyltransferase TrmD family
Xdur_006805	COG0335	large ribosomal subunit rRNA binding
Xdur_006810	COG0534	Mate efflux family protein
Xdur_006830	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Xdur_006840	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Xdur_006850	COG3209	COG3209 Rhs family protein
Xdur_006875	COG3250	beta-galactosidase activity
Xdur_006880	COG3867	Arabinogalactan endo-beta-1,4-galactanase
Xdur_006900	COG1960	acyl-CoA dehydrogenase activity
Xdur_006905	COG1024	Enoyl-CoA hydratase
Xdur_006925	COG1024	Enoyl-CoA hydratase
Xdur_006925	COG1250	3-hydroxyacyl-CoA dehydrogenase
Xdur_006940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Xdur_006945	COG0481	GTPase activity
Xdur_006960	COG0571	ribonuclease III activity
Xdur_006965	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Xdur_006970	COG1381	Involved in DNA repair and RecF pathway recombination
Xdur_006980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Xdur_006985	COG2954	triphosphatase activity
Xdur_006990	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Xdur_006995	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
Xdur_007000	COG3046	protein related to deoxyribodipyrimidine photolyase
Xdur_007005	COG1472	Belongs to the glycosyl hydrolase 3 family
Xdur_007010	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Xdur_007015	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Xdur_007020	COG1278	Cold shock
Xdur_007025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Xdur_007035	COG1201	RNA secondary structure unwinding
Xdur_007040	COG1793	dna ligase
Xdur_007050	COG1793	dna ligase
Xdur_007050	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Xdur_007080	COG0183	Belongs to the thiolase family
Xdur_007105	COG1451	nucleotide metabolic process
Xdur_007110	COG5487	UPF0391 membrane protein
Xdur_007120	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Xdur_007135	COG1077	Cell shape determining protein MreB Mrl
Xdur_007140	COG1047	Peptidyl-prolyl cis-trans
Xdur_007150	COG2824	Alkylphosphonate utilization operon protein PhnA
Xdur_007155	COG1902	pentaerythritol trinitrate reductase activity
Xdur_007160	COG2814	Major facilitator Superfamily
Xdur_007195	COG0392	lysyltransferase activity
Xdur_007195	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Xdur_007205	COG0251	oxidation-reduction process
Xdur_007210	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Xdur_007225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Xdur_007250	COG1595	DNA-templated transcription, initiation
Xdur_007265	COG2878	Part of a membrane complex involved in electron transport
Xdur_007275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Xdur_007275	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Xdur_007290	COG1131	(ABC) transporter
Xdur_007295	COG0346	lactoylglutathione lyase activity
Xdur_007300	COG0833	amino acid
Xdur_007305	COG2040	homocysteine
Xdur_007315	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Xdur_007335	COG1695	Transcriptional regulator
Xdur_007355	COG1981	membrane
Xdur_007370	COG0825	malonyl-CoA metabolic process
Xdur_007380	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Xdur_007385	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Xdur_007390	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Xdur_007395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Xdur_007400	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Xdur_007415	COG0750	zinc metalloprotease
Xdur_007420	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Xdur_007425	COG0575	Belongs to the CDS family
Xdur_007430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Xdur_007435	COG0233	cytoplasmic translational termination
Xdur_007440	COG0528	UMP kinase activity
Xdur_007450	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Xdur_007455	COG0052	Belongs to the universal ribosomal protein uS2 family
Xdur_007495	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Xdur_007505	COG1393	Belongs to the ArsC family
Xdur_007510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Xdur_007515	COG0367	asparagine synthase
Xdur_007540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Xdur_007570	COG1566	PFAM secretion protein HlyD family protein
Xdur_007575	COG2814	Major facilitator Superfamily
Xdur_007625	COG0339	signal peptide processing
Xdur_007630	COG0386	Belongs to the glutathione peroxidase family
Xdur_007685	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Xdur_007690	COG0084	hydrolase, TatD family'
Xdur_007705	COG1960	acyl-CoA dehydrogenase activity
Xdur_007720	COG0367	asparagine synthase
Xdur_007730	COG0305	Participates in initiation and elongation during chromosome replication
Xdur_007735	COG0415	Belongs to the DNA photolyase family
Xdur_007745	COG0583	DNA-binding transcription factor activity
Xdur_007790	COG3706	GGDEF domain
Xdur_007815	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Xdur_007830	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Xdur_007840	COG0497	DNA recombination
Xdur_007845	COG1420	regulation of RNA biosynthetic process
Xdur_007850	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Xdur_007855	COG0443	Heat shock 70 kDa protein
Xdur_007860	COG0484	heat shock protein binding
Xdur_007870	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
Xdur_007900	COG0583	DNA-binding transcription factor activity
Xdur_007905	COG1132	(ABC) transporter
Xdur_007940	COG2850	peptidyl-arginine hydroxylation
Xdur_007960	COG1253	flavin adenine dinucleotide binding
Xdur_007990	COG1131	(ABC) transporter
Xdur_007995	COG1725	Transcriptional regulator
Xdur_008005	COG0386	Belongs to the glutathione peroxidase family
Xdur_008020	COG2900	Belongs to the SlyX family
Xdur_008045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Xdur_008055	COG0646	methionine synthase
Xdur_008055	COG1410	methionine synthase
Xdur_008060	COG0646	methionine synthase
Xdur_008060	COG1410	methionine synthase
Xdur_008065	COG2226	methyltransferase
Xdur_008070	COG1960	acyl-CoA dehydrogenase activity
Xdur_008075	COG1960	acyl-CoA dehydrogenase activity
Xdur_008080	COG1960	acyl-CoA dehydrogenase activity
Xdur_008085	COG1960	acyl-CoA dehydrogenase activity
Xdur_008100	COG0557	exoribonuclease II activity
Xdur_008110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Xdur_008120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Xdur_008130	COG0704	Plays a role in the regulation of phosphate uptake
Xdur_008135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Xdur_008140	COG0581	inorganic phosphate transmembrane transporter activity
Xdur_008145	COG0573	inorganic phosphate transmembrane transporter activity
Xdur_008150	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Xdur_008175	COG0659	secondary active sulfate transmembrane transporter activity
Xdur_008180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Xdur_008190	COG1024	Enoyl-CoA hydratase
Xdur_008200	COG0494	nUDIX hydrolase
Xdur_008235	COG0488	(ABC) transporter
Xdur_008245	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Xdur_008245	COG0116	Belongs to the methyltransferase superfamily
Xdur_008250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Xdur_008275	COG2925	Exonuclease
Xdur_008285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Xdur_008290	COG3844	kynureninase activity
Xdur_008300	COG0662	Cupin 2, conserved barrel domain protein
Xdur_008305	COG0288	reversible hydration of carbon dioxide
Xdur_008380	COG2808	Putative FMN-binding domain
Xdur_008400	COG0017	Asparaginyl-tRNA synthetase
Xdur_008405	COG0316	Belongs to the HesB IscA family
Xdur_008410	COG0360	Binds together with S18 to 16S ribosomal RNA
Xdur_008415	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Xdur_008420	COG0359	binds to the 23S rRNA
Xdur_008430	COG3115	cell septum assembly
Xdur_008440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Xdur_008445	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Xdur_008450	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Xdur_008465	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Xdur_008475	COG4993	Dehydrogenase
Xdur_008485	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Xdur_008495	COG2986	histidine ammonia-lyase
Xdur_008500	COG1228	amidohydrolase
Xdur_008545	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Xdur_008550	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Xdur_008555	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Xdur_008560	COG0077	Prephenate dehydratase
Xdur_008560	COG1605	Chorismate mutase
Xdur_008565	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Xdur_008580	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Xdur_008585	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Xdur_008590	COG0583	DNA-binding transcription factor activity
Xdur_008655	COG0840	transmembrane signaling receptor activity
Xdur_008680	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Xdur_008685	COG4191	Histidine kinase
Xdur_008685	COG0784	Response regulator, receiver
Xdur_008700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Xdur_008710	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Xdur_008720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Xdur_008735	COG1595	DNA-templated transcription, initiation
Xdur_008785	COG2244	polysaccharide biosynthetic process
Xdur_008815	COG2264	protein methyltransferase activity
Xdur_008825	COG0438	transferase activity, transferring glycosyl groups
Xdur_008840	COG1136	(ABC) transporter
Xdur_008850	COG0477	Major facilitator Superfamily
Xdur_008855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Xdur_008870	COG1253	flavin adenine dinucleotide binding
Xdur_008880	COG0306	phosphate transporter
Xdur_008905	COG0504	CTP synthase activity
Xdur_008910	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Xdur_008920	COG0148	phosphopyruvate hydratase activity
Xdur_008925	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Xdur_008930	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Xdur_008935	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Xdur_008940	COG0585	pseudouridine synthase activity
Xdur_008945	COG2840	Smr protein MutS2
Xdur_008950	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Xdur_008955	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Xdur_008960	COG1238	metal cluster binding
Xdur_008975	COG1534	Rna-binding protein
Xdur_008980	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Xdur_008990	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Xdur_008995	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Xdur_009005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Xdur_009010	COG1546	Belongs to the CinA family
Xdur_009020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Xdur_009025	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Xdur_009030	COG2137	regulation of response to DNA damage stimulus
Xdur_009035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Xdur_009040	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Xdur_009055	COG1741	Belongs to the pirin family
Xdur_009060	COG0583	DNA-binding transcription factor activity
Xdur_009085	COG0351	phosphomethylpyrimidine kinase
Xdur_009085	COG0352	thiamine-phosphate diphosphorylase activity
Xdur_009100	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Xdur_009105	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Xdur_009120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Xdur_009130	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Xdur_009135	COG3734	2-keto-3-deoxy-galactonokinase
Xdur_009145	COG4948	Mandelate Racemase Muconate Lactonizing
Xdur_009150	COG0800	Aldolase
Xdur_009185	COG1501	Belongs to the glycosyl hydrolase 31 family
Xdur_009195	COG1070	Carbohydrate kinase
Xdur_009200	COG2115	Belongs to the xylose isomerase family
Xdur_009205	COG0477	Major facilitator Superfamily
Xdur_009225	COG0860	N-Acetylmuramoyl-L-alanine amidase
Xdur_009230	COG1469	GTP cyclohydrolase I activity
Xdur_009250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Xdur_009255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Xdur_009260	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Xdur_009265	COG0166	Belongs to the GPI family
Xdur_009285	COG1472	Belongs to the glycosyl hydrolase 3 family
Xdur_009295	COG4251	negative regulation of phosphorylation
Xdur_009295	COG3706	GGDEF domain
Xdur_009295	COG2203	Gaf domain
Xdur_009295	COG5001	Diguanylate cyclase
Xdur_009305	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Xdur_009310	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Xdur_009320	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Xdur_009325	COG0671	phosphoesterase, PA-phosphatase related
Xdur_009340	COG1794	racemase activity, acting on amino acids and derivatives
Xdur_009345	COG0697	spore germination
Xdur_009350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Xdur_009355	COG0167	dihydroorotate dehydrogenase activity
Xdur_009370	COG1012	belongs to the aldehyde dehydrogenase family
Xdur_009385	COG1215	transferase activity, transferring glycosyl groups
Xdur_009390	COG0726	polysaccharide deacetylase
Xdur_009390	COG1649	PFAM Uncharacterised BCR, COG1649
Xdur_009475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Xdur_009480	COG0124	histidyl-tRNA synthetase
Xdur_009490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Xdur_009495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Xdur_009500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Xdur_009505	COG0131	Imidazoleglycerol-phosphate dehydratase
Xdur_009505	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Xdur_009510	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Xdur_009515	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Xdur_009520	COG0107	imidazoleglycerol-phosphate synthase activity
Xdur_009525	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Xdur_009525	COG0140	phosphoribosyl-ATP diphosphatase activity
Xdur_009540	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Xdur_009545	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Xdur_009550	COG0235	Class ii aldolase
Xdur_009555	COG0531	amino acid
Xdur_009560	COG0531	amino acid
Xdur_009570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Xdur_009575	COG0277	FAD linked oxidase domain protein
Xdur_009595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Xdur_009640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Xdur_009645	COG2258	MOSC domain
Xdur_009650	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Xdur_009655	COG0505	Belongs to the CarA family
Xdur_009665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Xdur_009670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Xdur_009680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Xdur_009720	COG3279	Response regulator of the LytR AlgR family
Xdur_009730	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Xdur_009740	COG2205	protein histidine kinase activity
Xdur_009740	COG2198	Histidine kinase
Xdur_009740	COG0784	Response regulator, receiver
Xdur_009745	COG1024	Enoyl-CoA hydratase
Xdur_009780	COG2267	carboxylic ester hydrolase activity
Xdur_009790	COG2201	protein-glutamate methylesterase activity
Xdur_009795	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Xdur_009805	COG0840	transmembrane signaling receptor activity
Xdur_009815	COG0835	chemotaxis
Xdur_009825	COG0840	transmembrane signaling receptor activity
Xdur_009830	COG0840	transmembrane signaling receptor activity
Xdur_009835	COG0840	transmembrane signaling receptor activity
Xdur_009840	COG0840	transmembrane signaling receptor activity
Xdur_009845	COG0840	transmembrane signaling receptor activity
Xdur_009850	COG0840	transmembrane signaling receptor activity
Xdur_009855	COG0840	transmembrane signaling receptor activity
Xdur_009860	COG0840	transmembrane signaling receptor activity
Xdur_009865	COG0840	transmembrane signaling receptor activity
Xdur_009875	COG0840	transmembrane signaling receptor activity
Xdur_009890	COG0840	transmembrane signaling receptor activity
Xdur_009895	COG2198	Histidine kinase
Xdur_009895	COG0643	Histidine kinase
Xdur_009900	COG0745	RESPONSE REGULATOR receiver
Xdur_009910	COG0835	chemotaxis
Xdur_009920	COG1360	Flagellar Motor Protein
Xdur_009925	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Xdur_010010	COG0641	radical SAM
Xdur_010020	COG0643	Histidine kinase
Xdur_010020	COG2198	Histidine kinase
Xdur_010020	COG0784	Response regulator, receiver
Xdur_010050	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Xdur_010075	COG1684	flagellar biosynthetic protein fliR
Xdur_010090	COG3190	flagellar
Xdur_010140	COG1677	Flagellar hook-basal body complex protein FliE
Xdur_010170	COG1028	Short-chain dehydrogenase reductase Sdr
Xdur_010175	COG1028	Short-chain dehydrogenase reductase Sdr
Xdur_010180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Xdur_010200	COG2201	protein-glutamate methylesterase activity
Xdur_010230	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Xdur_010240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Xdur_010245	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Xdur_010255	COG3951	Flagellar rod assembly protein muramidase FlgJ
Xdur_010255	COG1705	Flagellar rod assembly protein muramidase FlgJ
Xdur_010260	COG1706	bacterial-type flagellum-dependent cell motility
Xdur_010265	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Xdur_010275	COG4787	bacterial-type flagellum-dependent cell motility
Xdur_010285	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Xdur_010290	COG1558	bacterial-type flagellum-dependent cell motility
Xdur_010300	COG0784	Response regulator, receiver
Xdur_010300	COG0835	chemotaxis
Xdur_010320	COG5002	protein histidine kinase activity
Xdur_010350	COG2915	High frequency lysogenization protein hflD homolog
Xdur_010355	COG0482	sulfurtransferase activity
Xdur_010370	COG0542	response to heat
Xdur_010380	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Xdur_010390	COG0492	ferredoxin-NADP+ reductase activity
Xdur_010395	COG1674	ftsk spoiiie
Xdur_010405	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Xdur_010415	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Xdur_010420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Xdur_010425	COG0183	Belongs to the thiolase family
Xdur_010430	COG1024	Enoyl-CoA hydratase
Xdur_010430	COG1250	3-hydroxyacyl-CoA dehydrogenase
Xdur_010445	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Xdur_010455	COG1426	Protein conserved in bacteria
Xdur_010465	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Xdur_010470	COG1160	GTP binding
Xdur_010475	COG0303	'Molybdopterin
Xdur_010480	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Xdur_010515	COG0708	Exodeoxyribonuclease III
Xdur_010525	COG0303	'Molybdopterin
Xdur_010530	COG0746	molybdenum cofactor guanylyltransferase activity
Xdur_010545	COG1914	H( )-stimulated, divalent metal cation uptake system
Xdur_010560	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Xdur_010565	COG0668	transmembrane transport
Xdur_010575	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Xdur_010590	COG1028	Short-chain dehydrogenase reductase Sdr
Xdur_010595	COG1183	phosphatidylcholine synthase activity
Xdur_010605	COG3243	poly(R)-hydroxyalkanoic acid synthase
Xdur_010620	COG0723	plastoquinol--plastocyanin reductase activity
Xdur_010620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Xdur_010630	COG2183	response to ionizing radiation
Xdur_010635	COG0784	Response regulator, receiver
Xdur_010635	COG2205	protein histidine kinase activity
Xdur_010700	COG0800	Aldolase
Xdur_010705	COG0129	dihydroxy-acid dehydratase activity
Xdur_010710	COG0363	glucosamine-6-phosphate deaminase activity
Xdur_010715	COG0837	glucose binding
Xdur_010720	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Xdur_010745	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
Xdur_010760	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Xdur_010765	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Xdur_010775	COG4591	ABC-type transport system involved in lipoprotein release permease component
Xdur_010780	COG1136	(ABC) transporter
Xdur_010795	COG0811	peptide transport
Xdur_010805	COG1132	(ABC) transporter
Xdur_010810	COG1663	tetraacyldisaccharide 4'-kinase activity
Xdur_010815	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Xdur_010820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Xdur_010830	COG0322	excinuclease ABC activity
Xdur_010835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Xdur_010845	COG0582	viral genome integration into host DNA
Xdur_010855	COG1396	sequence-specific DNA binding
Xdur_010860	COG0583	DNA-binding transcription factor activity
Xdur_010960	COG2003	Belongs to the UPF0758 family
Xdur_011055	COG3344	reverse transcriptase
Xdur_011155	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Xdur_011160	COG0629	single-stranded DNA binding
Xdur_011210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Xdur_011215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Xdur_011230	COG0582	viral genome integration into host DNA
Xdur_011240	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Xdur_011260	COG1054	Belongs to the UPF0176 family
Xdur_011270	COG1530	ribonuclease E activity
Xdur_011280	COG3064	Membrane
Xdur_011285	COG0428	transporter
Xdur_011295	COG2154	pterin-4-alpha-carbinolamine dehydratase
Xdur_011300	COG0316	Belongs to the HesB IscA family
Xdur_011300	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Xdur_011345	COG1073	alpha beta
Xdur_011345	COG2226	methyltransferase
Xdur_011390	COG1396	sequence-specific DNA binding
Xdur_011395	COG5489	Protein of unknown function (DUF736)
Xdur_011405	COG2003	Belongs to the UPF0758 family
Xdur_011435	COG0582	viral genome integration into host DNA
Xdur_011460	COG2336	PFAM SpoVT AbrB
Xdur_011485	COG4206	TonB-dependent receptor
Xdur_011505	COG2273	Hydrolase Family 16
Xdur_011505	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Xdur_011525	COG2274	protein secretion by the type I secretion system
Xdur_011580	COG0270	DNA (cytosine-5-)-methyltransferase activity
Xdur_011640	COG5006	permease, DMT superfamily
Xdur_011655	COG2249	NAD(P)H dehydrogenase (quinone) activity
Xdur_011665	COG3938	Belongs to the proline racemase family
Xdur_011680	COG2807	transmembrane transport
Xdur_011685	COG2207	Transcriptional regulator
Xdur_011805	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Xdur_011820	COG3311	Transcriptional regulator
Xdur_011875	COG2003	Belongs to the UPF0758 family
Xdur_011940	COG1063	alcohol dehydrogenase
Xdur_011950	COG2271	Major facilitator Superfamily
Xdur_011955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Xdur_011960	COG0066	3-isopropylmalate dehydratase activity
Xdur_011995	COG3246	L-lysine catabolic process to acetate
Xdur_012000	COG1250	3-hydroxyacyl-CoA dehydrogenase
Xdur_012005	COG1960	acyl-CoA dehydrogenase activity
Xdur_012010	COG1024	Enoyl-CoA hydratase
Xdur_012020	COG0318	PFAM AMP-dependent synthetase and ligase
Xdur_012025	COG1063	alcohol dehydrogenase
Xdur_012030	COG2086	electron transfer activity
Xdur_012045	COG0583	DNA-binding transcription factor activity
Xdur_012050	COG1396	sequence-specific DNA binding
Xdur_012090	COG1309	transcriptional regulator
Xdur_012105	COG1538	Outer membrane efflux protein
Xdur_012125	COG0583	DNA-binding transcription factor activity
Xdur_012130	COG1396	sequence-specific DNA binding
Xdur_012140	COG0582	viral genome integration into host DNA
Xdur_012215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Xdur_012290	COG0629	single-stranded DNA binding
Xdur_012295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Xdur_012300	COG0270	DNA (cytosine-5-)-methyltransferase activity
Xdur_012405	COG3344	reverse transcriptase
Xdur_012525	COG0210	DNA helicase
Xdur_012605	COG2084	Dehydrogenase
Xdur_012625	COG2003	Belongs to the UPF0758 family
Xdur_012665	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Xdur_012665	COG0519	Catalyzes the synthesis of GMP from XMP
Xdur_012675	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Xdur_012685	COG0475	glutathione-regulated potassium exporter activity
Xdur_012685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Xdur_012690	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Xdur_012700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Xdur_012705	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Xdur_012715	COG0776	regulation of translation
Xdur_012720	COG0539	negative regulation of cytoplasmic translation
Xdur_012725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Xdur_012740	COG2957	Belongs to the agmatine deiminase family
Xdur_012745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Xdur_012770	COG0395	ABC-type sugar transport system, permease component
Xdur_012775	COG1175	transmembrane transport
Xdur_012805	COG2350	Protein conserved in bacteria
Xdur_012810	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Xdur_012815	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Xdur_012820	COG1187	pseudouridine synthase activity
Xdur_012840	COG0436	Aminotransferase
Xdur_012845	COG4133	protoheme IX ABC transporter activity
Xdur_012865	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Xdur_012870	COG1138	Cytochrome C-type biogenesis protein
Xdur_012890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Xdur_012895	COG1278	Cold shock
Xdur_012900	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Xdur_012905	COG4988	ABC transporter
Xdur_012915	COG1294	oxidase, subunit
Xdur_012940	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Xdur_012950	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Xdur_012960	COG0165	Argininosuccinate lyase
Xdur_012965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Xdur_012975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Xdur_012980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Xdur_012990	COG0137	argininosuccinate synthase activity
Xdur_012995	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Xdur_013005	COG0215	cysteine-tRNA ligase activity
Xdur_013010	COG2166	iron-sulfur cluster assembly
Xdur_013025	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Xdur_013030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Xdur_013060	COG4302	ethanolamine ammonia-lyase activity
Xdur_013115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Xdur_013120	COG0402	S-adenosylhomocysteine deaminase activity
Xdur_013130	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Xdur_013135	COG1509	lysine 2,3-aminomutase activity
Xdur_013140	COG3300	MHYT domain
Xdur_013140	COG5001	Diguanylate cyclase
Xdur_013155	COG0483	inositol monophosphate 1-phosphatase activity
Xdur_013160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Xdur_013175	COG0488	(ABC) transporter
Xdur_013180	COG0513	Belongs to the DEAD box helicase family
Xdur_013185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Xdur_013190	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Xdur_013205	COG0625	glutathione transferase activity
Xdur_013215	COG4681	YaeQ
Xdur_013220	COG2081	HI0933 family
Xdur_013230	COG0501	Belongs to the peptidase M48B family
Xdur_013235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Xdur_013240	COG1028	Short-chain dehydrogenase reductase Sdr
Xdur_013265	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Xdur_013270	COG0860	N-Acetylmuramoyl-L-alanine amidase
Xdur_013275	COG0802	atpase or kinase
Xdur_013280	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Xdur_013280	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Xdur_013285	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Xdur_013290	COG1570	exodeoxyribonuclease VII activity
Xdur_013300	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Xdur_013495	COG0835	chemotaxis
Xdur_013500	COG0840	transmembrane signaling receptor activity
Xdur_013505	COG2094	Belongs to the DNA glycosylase MPG family
Xdur_013510	COG1201	RNA secondary structure unwinding
Xdur_013530	COG2969	positive regulation of protein catabolic process
Xdur_013535	COG0625	glutathione transferase activity
Xdur_013540	COG2857	Cytochrome c1
Xdur_013545	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Xdur_013550	COG0723	plastoquinol--plastocyanin reductase activity
Xdur_013555	COG0741	lytic transglycosylase activity
Xdur_013570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Xdur_013575	COG1702	phosphate starvation-inducible protein PhoH
Xdur_013585	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Xdur_013595	COG4535	Mg2 and Co2 transporter CorC
Xdur_013610	COG1012	belongs to the aldehyde dehydrogenase family
Xdur_013615	COG1177	transmembrane transport
Xdur_013620	COG1176	ABC-type spermidine putrescine transport system, permease component I
Xdur_013625	COG3842	ATPase activity
Xdur_013645	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Xdur_013660	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Xdur_013665	COG0174	glutamine synthetase
Xdur_013670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Xdur_013680	COG2703	oxygen carrier activity
Xdur_013685	COG0477	Major facilitator Superfamily
Xdur_013695	COG0243	molybdopterin cofactor binding
Xdur_013700	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Xdur_013705	COG2223	nitrite transmembrane transporter activity
Xdur_013710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Xdur_013720	COG2733	membrane
Xdur_013725	COG2205	protein histidine kinase activity
Xdur_013725	COG5002	protein histidine kinase activity
Xdur_013725	COG0784	Response regulator, receiver
Xdur_013735	COG0477	Major facilitator Superfamily
Xdur_013745	COG2902	Dehydrogenase
Xdur_013755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xdur_013760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Xdur_013765	COG1609	Transcriptional regulator
Xdur_013770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Xdur_013770	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Xdur_013775	COG1105	Belongs to the carbohydrate kinase PfkB family
Xdur_013780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Xdur_013780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Xdur_013825	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Xdur_013835	COG1862	Preprotein translocase
Xdur_013840	COG0343	queuine tRNA-ribosyltransferase activity
Xdur_013845	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Xdur_013880	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Xdur_013885	COG3291	Pkd domain containing protein
Xdur_013890	COG0405	Gamma-glutamyltransferase
Xdur_013895	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Xdur_013905	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Xdur_013910	COG0742	ribosomal rna small subunit methyltransferase
Xdur_013915	COG0326	Molecular chaperone. Has ATPase activity
Xdur_014010	COG0531	amino acid
Xdur_014025	COG0006	proline dipeptidase activity
Xdur_014035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Xdur_014050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Xdur_014055	COG3938	Belongs to the proline racemase family
Xdur_014065	COG0552	protein localization to endoplasmic reticulum
Xdur_014070	COG1194	a g-specific adenine glycosylase
Xdur_014075	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Xdur_014080	COG4191	Histidine kinase
Xdur_014080	COG0784	Response regulator, receiver
Xdur_014095	COG0322	excinuclease ABC activity
Xdur_014110	COG3040	lipid binding
Xdur_014125	COG1960	acyl-CoA dehydrogenase activity
Xdur_014135	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Xdur_014155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Xdur_014160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Xdur_014165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Xdur_014190	COG0438	transferase activity, transferring glycosyl groups
Xdur_014200	COG0438	transferase activity, transferring glycosyl groups
Xdur_014205	COG0438	transferase activity, transferring glycosyl groups
Xdur_014255	COG0072	phenylalanine-tRNA ligase activity
Xdur_014255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Xdur_014260	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Xdur_014275	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Xdur_014280	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Xdur_014305	COG1082	Xylose isomerase domain protein TIM barrel
Xdur_014325	COG0366	Alpha amylase catalytic
Xdur_014385	COG3702	type iv secretory pathway
Xdur_014405	COG2948	multi-organism process
Xdur_014425	COG3505	Type IV secretory pathway VirD4
Xdur_014440	COG0556	nucleotide-excision repair
Xdur_014530	COG4695	Portal protein
Xdur_014575	COG3179	chitinase
Xdur_014670	COG3275	phosphorelay sensor kinase activity
Xdur_014675	COG1611	Belongs to the LOG family
Xdur_014685	COG2095	MarC family integral membrane protein
Xdur_014695	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Xdur_014730	COG1185	polyribonucleotide nucleotidyltransferase activity
Xdur_014735	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Xdur_014740	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Xdur_014745	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Xdur_014750	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Xdur_014755	COG0195	Participates in both transcription termination and antitermination
Xdur_014760	COG0779	Required for maturation of 30S ribosomal subunits
Xdur_014770	COG1007	ATP synthesis coupled electron transport
Xdur_014795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Xdur_014800	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Xdur_014810	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Xdur_014815	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Xdur_014820	COG0649	NAD binding
Xdur_014825	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Xdur_014830	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Xdur_014835	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Xdur_014850	COG0149	triose-phosphate isomerase activity
Xdur_014855	COG0300	oxidoreductase activity
Xdur_014885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Xdur_014890	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Xdur_014895	COG0159	tryptophan synthase activity
Xdur_014905	COG0133	tryptophan synthase activity
Xdur_014915	COG0135	phosphoribosylanthranilate isomerase activity
Xdur_014920	COG0101	tRNA pseudouridine synthase activity
Xdur_014940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Xdur_014945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Xdur_014950	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Xdur_014955	COG2890	protein-(glutamine-N5) methyltransferase activity
Xdur_014965	COG0688	phosphatidylethanolamine metabolic process
Xdur_014975	COG0433	COG0433 Predicted ATPase
Xdur_014980	COG0494	nUDIX hydrolase
Xdur_014995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Xdur_015000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Xdur_015025	COG0717	Belongs to the dCTP deaminase family
Xdur_015030	COG0489	protein tyrosine kinase activity
Xdur_015050	COG3590	peptidase
Xdur_015055	COG3590	peptidase
Xdur_015075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Xdur_015080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Xdur_015085	COG2311	Membrane
Xdur_015090	COG1047	Peptidyl-prolyl cis-trans
Xdur_015095	COG0791	NLP P60 protein
Xdur_015100	COG0791	NLP P60 protein
Xdur_015110	COG4106	trans-aconitate 2-methyltransferase activity
Xdur_015115	COG1301	dicarboxylic acid transport
Xdur_015120	COG1785	Belongs to the alkaline phosphatase family
Xdur_015125	COG0037	tRNA processing
Xdur_015130	COG1722	exodeoxyribonuclease VII activity
Xdur_015135	COG0142	geranyltranstransferase activity
Xdur_015140	COG4104	PAAR repeat-containing protein
Xdur_015150	COG0312	modulator of DNA gyrase
Xdur_015155	COG3028	Belongs to the UPF0307 family
Xdur_015160	COG0312	modulator of DNA gyrase
Xdur_015170	COG3164	Protein of unknown function
Xdur_015180	COG0424	maF-like protein
Xdur_015185	COG2968	Membrane
Xdur_015200	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Xdur_015215	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Xdur_015230	COG0495	leucyl-tRNA aminoacylation
Xdur_015240	COG3118	belongs to the thioredoxin family
Xdur_015265	COG2155	Conserved Protein
Xdur_015310	COG1132	(ABC) transporter
Xdur_015340	COG1538	Outer membrane efflux protein
Xdur_015345	COG0745	RESPONSE REGULATOR receiver
Xdur_015350	COG5000	phosphorelay sensor kinase activity
Xdur_015350	COG5002	protein histidine kinase activity
Xdur_015355	COG0475	glutathione-regulated potassium exporter activity
Xdur_015365	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Xdur_015385	COG1187	pseudouridine synthase activity
Xdur_015390	COG5001	Diguanylate cyclase
Xdur_015390	COG5002	protein histidine kinase activity
Xdur_015510	COG0667	Aldo Keto reductase
Xdur_015515	COG2814	Major facilitator Superfamily
Xdur_015520	COG0583	DNA-binding transcription factor activity
Xdur_015530	COG2207	Transcriptional regulator
Xdur_015540	COG1309	transcriptional regulator
Xdur_015550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Xdur_015565	COG0735	belongs to the Fur family
Xdur_015570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Xdur_015595	COG4452	Inner membrane protein CreD
Xdur_015610	COG2205	protein histidine kinase activity
Xdur_015615	COG0745	RESPONSE REGULATOR receiver
Xdur_015620	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Xdur_015630	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Xdur_015660	COG0643	Histidine kinase
Xdur_015660	COG2198	Histidine kinase
Xdur_015665	COG0840	transmembrane signaling receptor activity
Xdur_015670	COG0835	chemotaxis
Xdur_015675	COG2202	Pas domain
Xdur_015675	COG2199	diguanylate cyclase activity
Xdur_015675	COG2200	EAL domain
Xdur_015680	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Xdur_015685	COG2201	protein-glutamate methylesterase activity
Xdur_015690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Xdur_015695	COG3590	peptidase
Xdur_015705	COG0588	phosphoglycerate mutase activity
Xdur_015710	COG1515	deoxyribonuclease V activity
Xdur_015720	COG1741	Belongs to the pirin family
Xdur_015735	COG1741	Belongs to the pirin family
Xdur_015740	COG1966	Carbon starvation protein
Xdur_015745	COG2879	small protein
Xdur_015780	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Xdur_015790	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Xdur_015810	COG2203	Gaf domain
Xdur_015810	COG3706	GGDEF domain
Xdur_015810	COG4251	negative regulation of phosphorylation
Xdur_015810	COG5001	Diguanylate cyclase
Xdur_015815	COG0629	single-stranded DNA binding
Xdur_015820	COG0142	geranyltranstransferase activity
Xdur_015830	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Xdur_015845	COG0527	aspartate kinase activity
Xdur_015850	COG0384	phenazine biosynthesis protein PhzF
Xdur_015855	COG0384	phenazine biosynthesis protein PhzF
Xdur_015865	COG1764	response to oxidative stress
Xdur_015870	COG0540	Belongs to the ATCase OTCase family
Xdur_015875	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Xdur_015880	COG1678	Uncharacterized ACR, COG1678
Xdur_015885	COG0519	Catalyzes the synthesis of GMP from XMP
Xdur_015900	COG5297	Belongs to the glycosyl hydrolase family 6
Xdur_015915	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Xdur_015930	COG0739	heme binding
Xdur_015950	COG0693	protein deglycase activity
Xdur_015960	COG1959	2 iron, 2 sulfur cluster binding
Xdur_015965	COG0719	Fe-S assembly protein
Xdur_015970	COG0396	ATPase activity
Xdur_015975	COG0719	Fe-S assembly protein
Xdur_015980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Xdur_015990	COG2146	nitrite reductase [NAD(P)H] activity
Xdur_015995	COG4774	siderophore transport
Xdur_016000	COG3128	pkhd-type hydroxylase
Xdur_016025	COG1477	protein flavinylation
Xdur_016030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Xdur_016045	COG1555	photosystem II stabilization
Xdur_016050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Xdur_016060	COG3178	'Phosphotransferase
Xdur_016065	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Xdur_016075	COG0628	permease
Xdur_016085	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Xdur_016095	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Xdur_016115	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Xdur_016120	COG0271	Belongs to the BolA IbaG family
Xdur_016130	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Xdur_016140	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Xdur_016145	COG1137	ATPase activity
Xdur_016160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Xdur_016165	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Xdur_016170	COG1660	Displays ATPase and GTPase activities
Xdur_016180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Xdur_016185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Xdur_016190	COG2239	Acts as a magnesium transporter
Xdur_016205	COG1294	oxidase, subunit
Xdur_016210	COG1271	oxidase subunit
Xdur_016220	COG1113	amino acid transport
Xdur_016240	COG2197	response regulator
Xdur_016250	COG0531	amino acid
Xdur_016270	COG1234	tRNA 3'-trailer cleavage
Xdur_016305	COG2814	Major facilitator Superfamily
Xdur_016310	COG0754	glutathionylspermidine amidase activity
Xdur_016335	COG1842	Phage shock protein A
Xdur_016345	COG0259	pyridoxamine-phosphate oxidase activity
Xdur_016350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Xdur_016355	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Xdur_016365	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Xdur_016440	COG0477	Major facilitator Superfamily
Xdur_016460	COG2198	Histidine kinase
Xdur_016460	COG2205	protein histidine kinase activity
Xdur_016460	COG0784	Response regulator, receiver
Xdur_016465	COG2353	YceI-like domain
Xdur_016485	COG1760	l-serine dehydratase
Xdur_016495	COG0460	homoserine dehydrogenase
Xdur_016495	COG0527	aspartate kinase activity
Xdur_016500	COG0626	cystathionine gamma-synthase activity
Xdur_016505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Xdur_016510	COG0739	heme binding
Xdur_016515	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Xdur_016520	COG1272	protein, Hemolysin III
Xdur_016525	COG2982	Protein involved in outer membrane biogenesis
Xdur_016530	COG0516	GMP reductase activity
Xdur_016530	COG0517	IMP dehydrogenase activity
Xdur_016535	COG0463	Glycosyl transferase, family 2
Xdur_016540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Xdur_016545	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Xdur_016555	COG4771	TonB-dependent receptor
Xdur_016565	COG1309	transcriptional regulator
Xdur_016575	COG1960	acyl-CoA dehydrogenase activity
Xdur_016605	COG0509	glycine decarboxylation via glycine cleavage system
Xdur_016610	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Xdur_016620	COG0330	HflC and HflK could
Xdur_016625	COG1742	UPF0060 membrane protein
Xdur_016630	COG3956	TIGRFAM MazG family protein
Xdur_016640	COG0494	nUDIX hydrolase
Xdur_016650	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Xdur_016655	COG0837	glucose binding
Xdur_016670	COG3858	chitin binding
Xdur_016670	COG1388	LysM domain
Xdur_016675	COG3525	Glycosyl hydrolase, family 20, catalytic domain
Xdur_016685	COG1472	Belongs to the glycosyl hydrolase 3 family
Xdur_016700	COG0531	amino acid
Xdur_016710	COG1486	melibiose metabolic process
Xdur_016720	COG3537	Alpha-1,2-mannosidase
Xdur_016755	COG3142	Participates in the control of copper homeostasis
Xdur_016760	COG1446	asparaginase
Xdur_016780	COG2198	Histidine kinase
Xdur_016780	COG0784	Response regulator, receiver
Xdur_016780	COG0643	Histidine kinase
Xdur_016785	COG0840	transmembrane signaling receptor activity
Xdur_016790	COG0835	chemotaxis
Xdur_016805	COG0189	ligase activity
Xdur_016815	COG1397	ADP-ribosylglycohydrolase
Xdur_016825	COG1199	ATP-dependent helicase activity
Xdur_016835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Xdur_016840	COG1215	transferase activity, transferring glycosyl groups
Xdur_016850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Xdur_016860	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Xdur_016865	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
Xdur_016870	COG0535	radical SAM domain protein
Xdur_016875	COG0535	radical SAM domain protein
Xdur_016890	COG0837	glucose binding
Xdur_016905	COG1643	Atp-dependent helicase
Xdur_016910	COG0783	Belongs to the Dps family
Xdur_016915	COG0514	ATP-dependent DNA helicase (RecQ)
Xdur_016945	COG0840	transmembrane signaling receptor activity
Xdur_016965	COG3920	Histidine kinase
Xdur_016970	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Xdur_016980	COG0602	queuosine metabolic process
Xdur_016990	COG2885	chlorophyll binding
Xdur_016995	COG0823	Involved in the tonB-independent uptake of proteins
Xdur_017005	COG0848	biopolymer transport protein
Xdur_017015	COG0824	Thioesterase
Xdur_017020	COG2255	four-way junction helicase activity
Xdur_017030	COG3158	transport of potassium into the cell
Xdur_017035	COG0632	four-way junction helicase activity
Xdur_017040	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Xdur_017045	COG0217	transcriptional regulatory protein
Xdur_017060	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Xdur_017075	COG0477	Major facilitator Superfamily
Xdur_017115	COG0488	(ABC) transporter
Xdur_017145	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Xdur_017145	COG4651	solute:proton antiporter activity
Xdur_017170	COG4772	TonB-dependent receptor
Xdur_017180	COG4264	IucA IucC family
Xdur_017195	COG0019	diaminopimelate decarboxylase activity
Xdur_017225	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Xdur_017235	COG1492	cobalamin metabolic process
Xdur_017245	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Xdur_017265	COG4206	TonB-dependent receptor
Xdur_017270	COG0542	response to heat
Xdur_017275	COG1116	anion transmembrane transporter activity
Xdur_017280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Xdur_017285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Xdur_017290	COG0667	Aldo Keto reductase
Xdur_017295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Xdur_017300	COG4771	TonB-dependent receptor
Xdur_017305	COG2827	Endonuclease containing a URI domain
Xdur_017345	COG1877	trehalose-phosphatase activity
Xdur_017350	COG3387	PFAM Glycoside hydrolase 15-related
Xdur_017365	COG0840	transmembrane signaling receptor activity
Xdur_017370	COG3011	Protein conserved in bacteria
Xdur_017385	COG0564	pseudouridine synthase activity
Xdur_017390	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Xdur_017400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Xdur_017400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Xdur_017420	COG2951	lytic endotransglycosylase activity
Xdur_017425	COG4644	lycopene metabolic process
Xdur_017485	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Xdur_017490	COG0045	succinate-CoA ligase (ADP-forming) activity
Xdur_017505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Xdur_017545	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Xdur_017550	COG0237	dephospho-CoA kinase activity
Xdur_017575	COG5002	protein histidine kinase activity
Xdur_017580	COG0745	RESPONSE REGULATOR receiver
Xdur_017685	COG2022	thiamine diphosphate biosynthetic process
Xdur_017690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Xdur_017695	COG0471	metal ion transport
Xdur_017695	COG3273	potassium ion transport
Xdur_017715	COG1970	mechanosensitive ion channel activity
Xdur_017735	COG3250	beta-galactosidase activity
Xdur_017740	COG4948	Mandelate Racemase Muconate Lactonizing
Xdur_017755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Xdur_017765	COG0308	aminopeptidase N
Xdur_017800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Xdur_017810	COG0529	Catalyzes the synthesis of activated sulfate
Xdur_017810	COG2895	sulfate adenylyltransferase (ATP) activity
Xdur_017815	COG0175	sulfate reduction
Xdur_017820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Xdur_017825	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Xdur_017830	COG0175	sulfate reduction
Xdur_017850	COG2205	protein histidine kinase activity
Xdur_017850	COG2198	Histidine kinase
Xdur_017850	COG0784	Response regulator, receiver
Xdur_017865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Xdur_017865	COG1648	precorrin-2 dehydrogenase activity
Xdur_017880	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Xdur_017885	COG3588	fructose-bisphosphate aldolase
Xdur_017890	COG0469	pyruvate kinase activity
Xdur_017900	COG0126	phosphoglycerate kinase activity
Xdur_017920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Xdur_017930	COG3047	cAMP biosynthetic process
Xdur_017935	COG3047	cAMP biosynthetic process
Xdur_017945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Xdur_017945	COG3453	Protein conserved in bacteria
Xdur_017950	COG0725	ABC transporter, periplasmic molybdate-binding protein
Xdur_017955	COG4149	molybdate abc transporter
Xdur_017960	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Xdur_017995	COG1376	ErfK ybiS ycfS ynhG family protein
Xdur_018000	COG0739	heme binding
Xdur_018010	COG4773	Receptor
Xdur_018015	COG0596	Alpha beta hydrolase
Xdur_018020	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Xdur_018025	COG1301	dicarboxylic acid transport
Xdur_018035	COG2304	oxidoreductase activity
Xdur_018055	COG0714	Associated with various cellular activities
Xdur_018085	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Xdur_018110	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Xdur_018120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Xdur_018130	COG0194	GDP metabolic process
Xdur_018135	COG1561	YicC-like family, N-terminal region
Xdur_018140	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Xdur_018150	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Xdur_018155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Xdur_018170	COG0006	proline dipeptidase activity
Xdur_018180	COG0006	proline dipeptidase activity
Xdur_018185	COG3079	Belongs to the UPF0149 family
Xdur_018205	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Xdur_018215	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Xdur_018225	COG2912	Transglutaminase-like superfamily
Xdur_018230	COG1773	rubredoxin
Xdur_018235	COG0352	thiamine-phosphate diphosphorylase activity
Xdur_018250	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Xdur_018265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Xdur_018295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Xdur_018300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Xdur_018310	COG1028	Short-chain dehydrogenase reductase Sdr
Xdur_018320	COG0671	phosphoesterase, PA-phosphatase related
Xdur_018325	COG3781	membrane
Xdur_018335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Xdur_018340	COG0563	adenylate kinase activity
Xdur_018355	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Xdur_018365	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Xdur_018385	COG3710	Transcriptional regulator
Xdur_018390	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Xdur_018400	COG0840	transmembrane signaling receptor activity
Xdur_018405	COG0405	Gamma-glutamyltransferase
Xdur_018410	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Xdur_018430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Xdur_018435	COG0473	3-isopropylmalate dehydrogenase activity
Xdur_018440	COG0066	3-isopropylmalate dehydratase activity
Xdur_018445	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Xdur_018465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Xdur_018470	COG1538	Outer membrane efflux protein
Xdur_018475	COG1519	Transferase
Xdur_018480	COG1560	Kdo2-lipid A biosynthetic process
Xdur_018505	COG0280	phosphate acetyltransferase
Xdur_018505	COG0281	malic enzyme
Xdur_018510	COG1301	dicarboxylic acid transport
Xdur_018535	COG0583	DNA-binding transcription factor activity
Xdur_018540	COG0667	Aldo Keto reductase
Xdur_018555	COG2197	response regulator
Xdur_018565	COG0642	Histidine kinase
Xdur_018580	COG2851	Citrate transporter
Xdur_018585	COG1028	Short-chain dehydrogenase reductase Sdr
Xdur_018590	COG1609	Transcriptional regulator
Xdur_018595	COG2211	Major facilitator Superfamily
Xdur_018620	COG1162	GTPase activity
Xdur_018640	COG4773	Receptor
Xdur_018645	COG0726	polysaccharide deacetylase
Xdur_018650	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Xdur_018680	COG1307	EDD domain protein, DegV family
Xdur_018685	COG0242	peptide deformylase activity
Xdur_018705	COG0457	Tetratricopeptide repeat
Xdur_018710	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Xdur_018715	COG1215	transferase activity, transferring glycosyl groups
Xdur_018720	COG1215	transferase activity, transferring glycosyl groups
Xdur_018735	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Xdur_018780	COG2188	Transcriptional regulator
Xdur_018800	COG1450	Type ii and iii secretion system protein
Xdur_018815	COG3166	PFAM Fimbrial assembly family protein
Xdur_018820	COG3156	type II secretion system protein K
Xdur_018825	COG4795	General secretion pathway protein
Xdur_018830	COG2165	general secretion pathway protein
Xdur_018835	COG4970	Tfp pilus assembly protein FimT
Xdur_018840	COG2165	general secretion pathway protein
Xdur_018845	COG1459	type II secretion system
Xdur_018850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Xdur_018855	COG1404	Belongs to the peptidase S8 family
Xdur_018860	COG5295	Hep Hag repeat protein
Xdur_018865	COG1404	Belongs to the peptidase S8 family
Xdur_018870	COG5295	Hep Hag repeat protein
Xdur_018875	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Xdur_018875	COG0047	phosphoribosylformylglycinamidine synthase activity
Xdur_018880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Xdur_018885	COG4974	Belongs to the 'phage' integrase family
Xdur_018900	COG0795	lipopolysaccharide-transporting ATPase activity
Xdur_018910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Xdur_018925	COG0525	valine-tRNA ligase activity
Xdur_018930	COG4206	TonB-dependent receptor
Xdur_018955	COG1183	phosphatidylcholine synthase activity
Xdur_018965	COG0442	prolyl-tRNA aminoacylation
Xdur_018980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Xdur_018985	COG1127	ABC transporter
Xdur_018990	COG3218	ABC-type transport auxiliary lipoprotein component
Xdur_018990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Xdur_019025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Xdur_019030	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Xdur_019030	COG0662	Cupin 2, conserved barrel domain protein
Xdur_019060	COG2086	electron transfer activity
Xdur_019075	COG0546	phosphoglycolate phosphatase activity
Xdur_019075	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Xdur_019080	COG0277	FAD linked oxidase domain protein
Xdur_019085	COG0300	oxidoreductase activity
Xdur_019095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Xdur_019115	COG2226	methyltransferase
Xdur_019125	COG3754	Rhamnan synthesis protein F
Xdur_019130	COG1216	Glycosyl transferase, family 2
Xdur_019130	COG0438	transferase activity, transferring glycosyl groups
Xdur_019135	COG0110	maltose O-acetyltransferase activity
Xdur_019150	COG0626	cystathionine gamma-synthase activity
Xdur_019180	COG0625	glutathione transferase activity
Xdur_019190	COG0513	Belongs to the DEAD box helicase family
Xdur_019200	COG4206	TonB-dependent receptor
Xdur_019205	COG0720	synthase
Xdur_019215	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Xdur_019220	COG1956	GAF domain-containing protein
Xdur_019225	COG2819	hydrolase of the alpha beta superfamily
Xdur_019240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Xdur_019245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Xdur_019260	COG0339	signal peptide processing
Xdur_019315	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Xdur_019320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xdur_019325	COG1136	(ABC) transporter
Xdur_019325	COG4591	ABC-type transport system involved in lipoprotein release permease component
Xdur_019330	COG0577	efflux transmembrane transporter activity
Xdur_019335	COG0577	efflux transmembrane transporter activity
Xdur_019350	COG4191	Histidine kinase
Xdur_019355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Xdur_019370	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Xdur_019375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Xdur_019380	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Xdur_019385	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Xdur_019390	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Xdur_019395	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Xdur_019405	COG0356	it plays a direct role in the translocation of protons across the membrane
Xdur_019425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Xdur_019435	COG0508	dehydrogenase complex catalyzes the overall conversion of
Xdur_019475	COG2011	ABC-type metal ion transport system permease component
Xdur_019480	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Xdur_019485	COG0697	spore germination
Xdur_019490	COG1666	GTP binding
Xdur_019500	COG0784	Response regulator, receiver
Xdur_019500	COG2198	Histidine kinase
Xdur_019500	COG5002	protein histidine kinase activity
Xdur_019520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Xdur_019525	COG1187	pseudouridine synthase activity
Xdur_019530	COG2813	Specifically methylates the guanine in position
Xdur_019550	COG2202	Pas domain
Xdur_019550	COG2205	protein histidine kinase activity
Xdur_019570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Xdur_019575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Xdur_019635	COG0842	Transport permease protein
Xdur_019640	COG1131	(ABC) transporter
Xdur_019645	COG0025	NhaP-type Na H and K H
Xdur_019650	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Xdur_019655	COG1573	uracil-dna glycosylase
Xdur_019665	COG3384	dioxygenase
Xdur_019675	COG0583	DNA-binding transcription factor activity
Xdur_019685	COG0667	Aldo Keto reductase
Xdur_019695	COG3590	peptidase
Xdur_019715	COG0531	amino acid
Xdur_019730	COG2972	Histidine kinase
Xdur_019745	COG3685	Protein conserved in bacteria
Xdur_019750	COG3546	catalase activity
Xdur_019795	COG1271	oxidase subunit
Xdur_019800	COG1294	oxidase, subunit
Xdur_019815	COG1028	Short-chain dehydrogenase reductase Sdr
Xdur_019820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Xdur_019840	COG1132	(ABC) transporter
Xdur_019855	COG1063	alcohol dehydrogenase
Xdur_019930	COG0251	oxidation-reduction process
Xdur_019945	COG0840	transmembrane signaling receptor activity
Xdur_019960	COG0583	DNA-binding transcription factor activity
Xdur_019965	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Xdur_020010	COG0024	Methionine aminopeptidase
Xdur_020050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Xdur_020080	COG4695	Portal protein
Xdur_020125	COG3179	chitinase
Xdur_020310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Xdur_020315	COG1490	D-aminoacyl-tRNA deacylase activity
Xdur_020320	COG1560	Kdo2-lipid A biosynthetic process
Xdur_020370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Xdur_020370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Xdur_020375	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Xdur_020380	COG0242	peptide deformylase activity
Xdur_020385	COG1652	LysM domain
Xdur_020390	COG0758	DNA mediated transformation
Xdur_020410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Xdur_020410	COG1754	DNA topoisomerase type I activity
Xdur_020415	COG0009	L-threonylcarbamoyladenylate synthase
Xdur_020430	COG1028	Short-chain dehydrogenase reductase Sdr
Xdur_020440	COG0616	signal peptide processing
Xdur_020445	COG0534	Mate efflux family protein
Xdur_020465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Xdur_020470	COG0625	glutathione transferase activity
Xdur_020485	COG1252	NADH dehydrogenase
Xdur_020490	COG2860	membrane
Xdur_020495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Xdur_020500	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Xdur_020505	COG2201	protein-glutamate methylesterase activity
Xdur_020510	COG2177	Part of the ABC transporter FtsEX involved in
Xdur_020515	COG2884	Cell division ATP-binding protein ftsE
Xdur_020520	COG0513	Belongs to the DEAD box helicase family
Xdur_020525	COG3118	belongs to the thioredoxin family
Xdur_020530	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Xdur_020535	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
Xdur_020540	COG0583	DNA-binding transcription factor activity
Xdur_020585	COG1518	maintenance of DNA repeat elements
Xdur_020590	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Xdur_020600	COG1652	LysM domain
Xdur_020605	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Xdur_020605	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Xdur_020610	COG1473	amidohydrolase
Xdur_020615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xdur_020620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Xdur_020630	COG5383	Protein conserved in bacteria
Xdur_020670	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
Xdur_020675	COG3023	N-Acetylmuramoyl-L-alanine amidase
Xdur_020685	COG4948	Mandelate Racemase Muconate Lactonizing
Xdur_020695	COG0531	amino acid
Xdur_020710	COG4682	membrane
Xdur_020715	COG2133	pyrroloquinoline quinone binding
Xdur_020725	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Xdur_020730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Xdur_020740	COG1610	YqeY-like protein
Xdur_020745	COG1295	ribonuclease BN
Xdur_020750	COG0358	DNA primase activity
Xdur_020765	COG0109	protoheme IX farnesyltransferase activity
Xdur_020795	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
Xdur_020810	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Xdur_020850	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Xdur_020855	COG0739	heme binding
Xdur_020860	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Xdur_020870	COG2223	nitrite transmembrane transporter activity
Xdur_020875	COG0708	Exodeoxyribonuclease III
Xdur_020880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Xdur_020890	COG1192	Involved in chromosome partitioning
Xdur_020895	COG1475	DNA binding
Xdur_020910	COG0463	Glycosyl transferase, family 2
Xdur_020930	COG0756	dUTP diphosphatase activity
Xdur_020935	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Xdur_020940	COG2003	Belongs to the UPF0758 family
Xdur_020945	COG0018	arginyl-trna synthetase
Xdur_020960	COG4221	oxidoreductase activity
Xdur_020965	COG2755	lipolytic protein G-D-S-L family
Xdur_020965	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Xdur_020975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Xdur_020980	COG1166	arginine decarboxylase activity
Xdur_020985	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Xdur_021020	COG0606	chelatase, subunit chli
Xdur_021035	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Xdur_021060	COG1690	Belongs to the RtcB family
Xdur_021100	COG1090	epimerase
Xdur_021110	COG0642	Histidine kinase
Xdur_021135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Xdur_021160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Xdur_021165	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Xdur_021180	COG0753	catalase activity
Xdur_021195	COG2197	response regulator
Xdur_021200	COG4585	Histidine kinase
Xdur_021205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xdur_021210	COG1136	(ABC) transporter
Xdur_021235	COG0697	spore germination
Xdur_021250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Xdur_021255	COG0180	Tryptophanyl-tRNA synthetase
Xdur_021300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Xdur_021315	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Xdur_021360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Xdur_021380	COG1199	ATP-dependent helicase activity
Xdur_021395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Xdur_021460	COG0625	glutathione transferase activity
Xdur_021495	COG4555	ABC transporter
Xdur_021505	COG1476	TRANSCRIPTIONal
Xdur_021550	COG0543	2 iron, 2 sulfur cluster binding
Xdur_021550	COG0633	Ferredoxin
Xdur_021555	COG1131	(ABC) transporter
Xdur_021560	COG0842	Transport permease protein
Xdur_021570	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Xdur_021605	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Xdur_021610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Xdur_021620	COG0045	succinate-CoA ligase (ADP-forming) activity
Xdur_021620	COG1042	CoA-binding domain protein
Xdur_021620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Xdur_021625	COG2239	Acts as a magnesium transporter
Xdur_021640	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Xdur_021645	COG3387	PFAM Glycoside hydrolase 15-related
Xdur_021660	COG3100	YcgL domain-containing protein
Xdur_021665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Xdur_021675	COG0463	Glycosyl transferase, family 2
Xdur_021695	COG1028	Short-chain dehydrogenase reductase Sdr
Xdur_021730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Xdur_021745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Xdur_021770	COG4946	Tricorn protease homolog
Xdur_021770	COG1506	peptidase
Xdur_021770	COG0823	Involved in the tonB-independent uptake of proteins
Xdur_021785	COG0408	coproporphyrinogen oxidase activity
Xdur_021830	COG2815	serine threonine protein kinase
Xdur_021830	COG0515	serine threonine protein kinase
Xdur_021835	COG0631	protein serine/threonine phosphatase activity
Xdur_022010	COG0210	DNA helicase
Xdur_022020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Xdur_022025	COG0583	DNA-binding transcription factor activity
Xdur_022030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Xdur_022040	COG2159	amidohydrolase
Xdur_022060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Xdur_022080	COG0357	Ribosomal RNA small subunit methyltransferase G
Xdur_022085	COG3540	Alkaline phosphatase
Xdur_022095	COG2091	lysine biosynthetic process via aminoadipic acid
Xdur_022110	COG0708	Exodeoxyribonuclease III
Xdur_022115	COG1940	carbohydrate kinase activity
Xdur_022115	COG1846	Transcriptional regulator
Xdur_022125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Xdur_022135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Xdur_022140	COG3162	membrane
Xdur_022150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Xdur_022175	COG3507	Belongs to the glycosyl hydrolase 43 family
Xdur_022195	COG1028	Short-chain dehydrogenase reductase Sdr
Xdur_022200	COG0179	Fumarylacetoacetate (FAA) hydrolase
Xdur_022205	COG4948	Mandelate Racemase Muconate Lactonizing
Xdur_022210	COG3254	rhamnose metabolic process
Xdur_022215	COG0738	Major facilitator superfamily
Xdur_022220	COG1414	Transcriptional regulator
Xdur_022225	COG1971	Probably functions as a manganese efflux pump
Xdur_022230	COG2205	protein histidine kinase activity
Xdur_022240	COG3459	Glycosyltransferase 36 associated
Xdur_022245	COG2211	Major facilitator Superfamily
Xdur_022250	COG3265	gluconokinase activity
Xdur_022255	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Xdur_022285	COG2911	Protein conserved in bacteria
Xdur_022290	COG0729	surface antigen
Xdur_022325	COG0752	glycyl-tRNA synthetase alpha subunit
Xdur_022330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Xdur_022340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Xdur_022340	COG0519	Catalyzes the synthesis of GMP from XMP
Xdur_022350	COG0805	protein transport
Xdur_022355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Xdur_022360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Xdur_022370	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Xdur_022390	COG2974	May be involved in recombination
Xdur_022395	COG0037	tRNA processing
Xdur_022400	COG2115	Belongs to the xylose isomerase family
Xdur_022410	COG3661	Belongs to the glycosyl hydrolase 67 family
Xdur_022420	COG4948	Mandelate Racemase Muconate Lactonizing
Xdur_022430	COG1472	Belongs to the glycosyl hydrolase 3 family
Xdur_022435	COG0246	Mannitol dehydrogenase
Xdur_022480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Xdur_022510	COG3386	PFAM SMP-30 Gluconolaconase
Xdur_022520	COG3250	beta-galactosidase activity
Xdur_022525	COG1904	glucuronate isomerase
Xdur_022530	COG3693	PFAM glycoside hydrolase, family 10
Xdur_022540	COG3693	PFAM glycoside hydrolase, family 10
Xdur_022555	COG2211	Major facilitator Superfamily
Xdur_022635	COG2937	Belongs to the GPAT DAPAT family
Xdur_022665	COG0284	orotidine-5'-phosphate decarboxylase activity
Xdur_022670	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
Xdur_022675	COG3132	Protein of unknown function, DUF480
Xdur_022690	COG0210	DNA helicase
Xdur_022695	COG1435	thymidine kinase activity
Xdur_022705	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Xdur_022715	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Xdur_022745	COG3135	benzoate transporter
Xdur_022765	COG0676	glucose-6-phosphate 1-epimerase activity
Xdur_022775	COG3012	SEC-C Motif Domain Protein
Xdur_022780	COG0730	response to heat
Xdur_022800	COG0302	gtp cyclohydrolase
Xdur_022815	COG1566	PFAM secretion protein HlyD family protein
Xdur_022825	COG1289	transmembrane transporter activity
Xdur_022830	COG0477	Major facilitator Superfamily
Xdur_022840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Xdur_022860	COG4691	Plasmid stability protein
Xdur_022865	COG1487	ribonuclease activity
Xdur_022900	COG0564	pseudouridine synthase activity
Xdur_022955	COG1074	ATP-dependent DNA helicase activity
Xdur_022960	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Xdur_022975	COG1127	ABC transporter
Xdur_022980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Xdur_022985	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Xdur_023000	COG2853	Lipoprotein
Xdur_023010	COG0386	Belongs to the glutathione peroxidase family
Xdur_023020	COG1322	Protein conserved in bacteria
Xdur_023025	COG0604	alcohol dehydrogenase
Xdur_023040	COG0625	glutathione transferase activity
Xdur_023050	COG0531	amino acid
Xdur_023055	COG3537	Alpha-1,2-mannosidase
Xdur_023065	COG3706	GGDEF domain
Xdur_023070	COG3835	regulator
Xdur_023075	COG1929	Belongs to the glycerate kinase type-1 family
Xdur_023080	COG2271	Major facilitator Superfamily
Xdur_023095	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Xdur_023100	COG0861	Integral membrane protein TerC family
Xdur_023110	COG0584	glycerophosphoryl diester phosphodiesterase
Xdur_023125	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Xdur_023130	COG0726	polysaccharide deacetylase
Xdur_023135	COG0706	membrane insertase activity
Xdur_023140	COG0594	ribonuclease P activity
Xdur_023270	COG0489	protein tyrosine kinase activity
Xdur_023365	COG3451	type IV secretory pathway VirB4
Xdur_023400	COG0745	RESPONSE REGULATOR receiver
Xdur_023405	COG0784	Response regulator, receiver
Xdur_023405	COG2205	protein histidine kinase activity
Xdur_023495	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Xdur_023595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Xdur_023675	COG2885	chlorophyll binding
Xdur_023695	COG1475	DNA binding
Xdur_023775	COG1192	Involved in chromosome partitioning
Xdur_023790	COG3012	SEC-C Motif Domain Protein
Xdur_023790	COG3318	Belongs to the UPF0149 family
Xdur_023885	COG3846	protein secretion by the type IV secretion system
Xdur_023900	COG3451	type IV secretory pathway VirB4
Xdur_023910	COG3838	Conjugal transfer protein Trbc
Xdur_023915	COG4962	Type ii secretion system protein e
Xdur_023985	COG0489	protein tyrosine kinase activity
Xdur_024085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Xdur_024145	COG2951	lytic endotransglycosylase activity
Xdur_024150	COG4644	lycopene metabolic process
Xdur_024185	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Xdur_024205	COG3012	SEC-C Motif Domain Protein
Xdur_024205	COG3318	Belongs to the UPF0149 family
Xdur_024225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Xdur_024230	COG4456	Virulence-associated protein