locus-tag	class	description
OM953_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
OM953_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OM953_00020	COG0187	DNA topoisomerase II activity
OM953_00030	COG0501	Belongs to the peptidase M48B family
OM953_00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
OM953_00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OM953_00120	COG0793	Belongs to the peptidase S41A family
OM953_00125	COG4942	peptidase
OM953_00135	COG2234	aminopeptidase activity
OM953_00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
OM953_00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
OM953_00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
OM953_00165	COG1064	alcohol dehydrogenase
OM953_00180	COG0493	'glutamate synthase
OM953_00185	COG0070	glutamate synthase
OM953_00185	COG0067	glutamate synthase
OM953_00185	COG0069	glutamate synthase activity
OM953_00265	COG1111	helicase
OM953_00265	COG1205	dead DEAH box helicase
OM953_00270	COG1272	protein, Hemolysin III
OM953_00290	COG0300	oxidoreductase activity
OM953_00295	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_00315	COG2249	NAD(P)H dehydrogenase (quinone) activity
OM953_00335	COG3237	CsbD-like
OM953_00380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OM953_00385	COG0477	Major facilitator Superfamily
OM953_00425	COG0714	Associated with various cellular activities
OM953_00465	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
OM953_00475	COG4772	TonB-dependent receptor
OM953_00490	COG1012	belongs to the aldehyde dehydrogenase family
OM953_00515	COG1304	FMN binding
OM953_00525	COG4585	Histidine kinase
OM953_00530	COG2197	response regulator
OM953_00550	COG3710	Transcriptional regulator
OM953_00555	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OM953_00710	COG0366	Alpha amylase catalytic
OM953_00715	COG0366	Alpha amylase catalytic
OM953_00720	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OM953_00745	COG2755	lipolytic protein G-D-S-L family
OM953_00745	COG0657	acetylesterase activity
OM953_00755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OM953_00770	COG3507	Belongs to the glycosyl hydrolase 43 family
OM953_00775	COG1609	Transcriptional regulator
OM953_00780	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
OM953_00785	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_00795	COG2755	lipolytic protein G-D-S-L family
OM953_00805	COG3186	Phenylalanine-4-hydroxylase
OM953_00810	COG1522	sequence-specific DNA binding
OM953_00820	COG1752	Esterase of the alpha-beta hydrolase superfamily
OM953_00830	COG1119	ATPase activity
OM953_00845	COG1125	glycine betaine transport
OM953_00860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OM953_00890	COG0489	protein tyrosine kinase activity
OM953_00895	COG2062	phosphohistidine phosphatase, SixA
OM953_00905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OM953_00950	COG1968	undecaprenyl-diphosphatase activity
OM953_00955	COG0174	glutamine synthetase
OM953_00960	COG0347	Belongs to the P(II) protein family
OM953_00965	COG0004	ammonium transporteR
OM953_00975	COG3852	Histidine kinase
OM953_00980	COG2204	response regulator
OM953_00985	COG2032	superoxide dismutase activity
OM953_00990	COG2032	superoxide dismutase activity
OM953_00995	COG0346	lactoylglutathione lyase activity
OM953_01005	COG0183	Belongs to the thiolase family
OM953_01040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OM953_01045	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
OM953_01050	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
OM953_01065	COG0028	Belongs to the TPP enzyme family
OM953_01070	COG2205	protein histidine kinase activity
OM953_01095	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OM953_01110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OM953_01120	COG0596	Alpha beta hydrolase
OM953_01125	COG0727	PFAM Uncharacterised protein family (UPF0153)
OM953_01130	COG0318	PFAM AMP-dependent synthetase and ligase
OM953_01135	COG0745	RESPONSE REGULATOR receiver
OM953_01145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OM953_01170	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OM953_01180	COG0564	pseudouridine synthase activity
OM953_01200	COG1446	asparaginase
OM953_01205	COG0339	signal peptide processing
OM953_01245	COG0475	glutathione-regulated potassium exporter activity
OM953_01250	COG0583	DNA-binding transcription factor activity
OM953_01255	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OM953_01260	COG2224	Isocitrate lyase
OM953_01290	COG4770	biotin carboxylase activity
OM953_01295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OM953_01300	COG1960	acyl-CoA dehydrogenase activity
OM953_01365	COG0697	spore germination
OM953_01375	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
OM953_01380	COG1846	Transcriptional regulator
OM953_01385	COG1764	response to oxidative stress
OM953_01410	COG2130	NADP-dependent
OM953_01425	COG1187	pseudouridine synthase activity
OM953_01440	COG1643	Atp-dependent helicase
OM953_01445	COG4807	Protein conserved in bacteria
OM953_01450	COG2351	hydroxyisourate hydrolase activity
OM953_01455	COG2072	flavoprotein involved in K transport
OM953_01475	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OM953_01485	COG0583	DNA-binding transcription factor activity
OM953_01520	COG2252	PERMEase
OM953_01540	COG0084	hydrolase, TatD family'
OM953_01550	COG0583	DNA-binding transcription factor activity
OM953_01555	COG2814	Major facilitator Superfamily
OM953_01565	COG2267	carboxylic ester hydrolase activity
OM953_01570	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
OM953_01575	COG1902	pentaerythritol trinitrate reductase activity
OM953_01595	COG0745	RESPONSE REGULATOR receiver
OM953_01600	COG2205	protein histidine kinase activity
OM953_01605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OM953_01630	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
OM953_01635	COG0583	DNA-binding transcription factor activity
OM953_01665	COG0702	epimerase
OM953_01670	COG1733	regulation of RNA biosynthetic process
OM953_01705	COG0129	dihydroxy-acid dehydratase activity
OM953_01720	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OM953_01775	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OM953_01780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OM953_01805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OM953_01810	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OM953_01820	COG3485	protocatechuate 3,4-dioxygenase
OM953_01825	COG3485	protocatechuate 3,4-dioxygenase
OM953_01835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OM953_01840	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OM953_01850	COG1414	Transcriptional regulator
OM953_01860	COG0657	acetylesterase activity
OM953_01870	COG0445	tRNA wobble uridine modification
OM953_01880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OM953_01905	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_01910	COG2267	carboxylic ester hydrolase activity
OM953_01920	COG0156	8-amino-7-oxononanoate synthase activity
OM953_01925	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
OM953_01930	COG1040	competence protein
OM953_01935	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
OM953_01970	COG5297	Belongs to the glycosyl hydrolase family 6
OM953_02025	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OM953_02095	COG1511	domain protein
OM953_02095	COG3264	Mechanosensitive ion channel
OM953_02100	COG1368	sulfuric ester hydrolase activity
OM953_02105	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OM953_02110	COG2354	Protein conserved in bacteria
OM953_02120	COG0297	glycogen (starch) synthase activity
OM953_02125	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OM953_02130	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OM953_02155	COG0702	epimerase
OM953_02160	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_02190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OM953_02195	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_02205	COG0513	Belongs to the DEAD box helicase family
OM953_02210	COG0508	dehydrogenase complex catalyzes the overall conversion of
OM953_02225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OM953_02235	COG3483	tryptophan 2,3-dioxygenase activity
OM953_02240	COG3104	oligopeptide transport
OM953_02270	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
OM953_02290	COG1320	monovalent cation:proton antiporter activity
OM953_02295	COG2212	antiporter activity
OM953_02305	COG0651	ATP synthesis coupled electron transport
OM953_02310	COG1006	Multisubunit Na H antiporter MnhC subunit
OM953_02315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OM953_02315	COG2111	Na H antiporter
OM953_02340	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
OM953_02345	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
OM953_02360	COG0456	acetyltransferase
OM953_02365	COG1597	lipid kinase activity
OM953_02395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OM953_02400	COG0134	indole-3-glycerol-phosphate synthase activity
OM953_02410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OM953_02415	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
OM953_02425	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
OM953_02435	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OM953_02450	COG1051	belongs to the nudix hydrolase family
OM953_02490	COG0316	Belongs to the HesB IscA family
OM953_02505	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
OM953_02520	COG2814	Major facilitator Superfamily
OM953_02530	COG2814	Major facilitator Superfamily
OM953_02535	COG1289	transmembrane transporter activity
OM953_02540	COG0151	Belongs to the GarS family
OM953_02550	COG0138	bifunctional purine biosynthesis protein purh
OM953_02555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OM953_02560	COG2267	carboxylic ester hydrolase activity
OM953_02565	COG2453	phosphatase
OM953_02565	COG0671	phosphoesterase, PA-phosphatase related
OM953_02590	COG4589	Belongs to the CDS family
OM953_02595	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
OM953_02620	COG2264	protein methyltransferase activity
OM953_02635	COG0439	Biotin carboxylase
OM953_02645	COG0511	ligase activity, forming carbon-carbon bonds
OM953_02650	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
OM953_02660	COG1324	tolerance protein
OM953_02670	COG2356	endonuclease I
OM953_02680	COG0459	protein refolding
OM953_02695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OM953_02710	COG3386	PFAM SMP-30 Gluconolaconase
OM953_02720	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
OM953_02725	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
OM953_02750	COG0778	Nitroreductase
OM953_02755	COG2353	YceI-like domain
OM953_02780	COG3052	prosthetic group binding
OM953_02810	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OM953_02820	COG1802	Transcriptional regulator
OM953_02980	COG1082	Xylose isomerase domain protein TIM barrel
OM953_03005	COG4221	oxidoreductase activity
OM953_03020	COG4221	oxidoreductase activity
OM953_03030	COG0435	Glutathione S-transferase
OM953_03065	COG1506	peptidase
OM953_03065	COG0823	Involved in the tonB-independent uptake of proteins
OM953_03100	COG0697	spore germination
OM953_03115	COG1113	amino acid transport
OM953_03135	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
OM953_03180	COG0840	transmembrane signaling receptor activity
OM953_03185	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
OM953_03185	COG5297	Belongs to the glycosyl hydrolase family 6
OM953_03190	COG0659	secondary active sulfate transmembrane transporter activity
OM953_03205	COG2943	transferase activity, transferring hexosyl groups
OM953_03215	COG3275	phosphorelay sensor kinase activity
OM953_03225	COG0181	hydroxymethylbilane synthase activity
OM953_03250	COG1505	serine-type exopeptidase activity
OM953_03255	COG0436	Aminotransferase
OM953_03265	COG2832	Protein of unknown function (DUF454)
OM953_03275	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
OM953_03285	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OM953_03290	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
OM953_03295	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
OM953_03320	COG2226	methyltransferase
OM953_03325	COG3300	MHYT domain
OM953_03325	COG5001	Diguanylate cyclase
OM953_03330	COG0308	aminopeptidase N
OM953_03375	COG3284	Transcriptional regulator
OM953_03380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OM953_03385	COG1077	Cell shape determining protein MreB Mrl
OM953_03390	COG1792	Involved in formation and maintenance of cell shape
OM953_03405	COG0772	Belongs to the SEDS family
OM953_03415	COG2951	lytic endotransglycosylase activity
OM953_03420	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OM953_03425	COG1686	Belongs to the peptidase S11 family
OM953_03435	COG2921	Belongs to the UPF0250 family
OM953_03440	COG0321	lipoyl(octanoyl) transferase activity
OM953_03445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OM953_03460	COG0583	DNA-binding transcription factor activity
OM953_03470	COG1051	belongs to the nudix hydrolase family
OM953_03470	COG1056	cytidyltransferase-related domain
OM953_03505	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
OM953_03510	COG0673	inositol 2-dehydrogenase activity
OM953_03515	COG2823	Periplasmic or secreted lipoprotein
OM953_03520	COG4251	negative regulation of phosphorylation
OM953_03525	COG0784	Response regulator, receiver
OM953_03530	COG4191	Histidine kinase
OM953_03535	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OM953_03590	COG1459	type II secretion system
OM953_03595	COG2165	general secretion pathway protein
OM953_03610	COG4795	General secretion pathway protein
OM953_03640	COG3250	beta-galactosidase activity
OM953_03655	COG2188	Transcriptional regulator
OM953_03665	COG1609	Transcriptional regulator
OM953_03670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OM953_03675	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OM953_03690	COG0617	tRNA 3'-terminal CCA addition
OM953_03695	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
OM953_03700	COG1012	belongs to the aldehyde dehydrogenase family
OM953_03705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OM953_03720	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OM953_03735	COG0218	Necessary for normal cell division and for the maintenance of normal septation
OM953_03740	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
OM953_03755	COG2205	protein histidine kinase activity
OM953_03785	COG3791	Glutathione-dependent formaldehyde-activating
OM953_03800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OM953_03810	COG0697	spore germination
OM953_03820	COG0488	(ABC) transporter
OM953_03830	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OM953_03835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OM953_03845	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OM953_03845	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OM953_03865	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
OM953_03870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OM953_03875	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OM953_03895	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
OM953_03900	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
OM953_03905	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
OM953_03910	COG2205	protein histidine kinase activity
OM953_03915	COG0745	RESPONSE REGULATOR receiver
OM953_03930	COG0277	FAD linked oxidase domain protein
OM953_03935	COG1988	membrane-bound metal-dependent
OM953_03940	COG0792	nuclease activity
OM953_03970	COG0275	rRNA processing
OM953_03975	COG3116	cell division
OM953_03985	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OM953_03990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OM953_03995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OM953_04005	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OM953_04010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OM953_04015	COG1181	Belongs to the D-alanine--D-alanine ligase family
OM953_04020	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OM953_04035	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
OM953_04045	COG0739	heme binding
OM953_04050	COG0653	protein targeting
OM953_04055	COG0494	nUDIX hydrolase
OM953_04065	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OM953_04075	COG0604	alcohol dehydrogenase
OM953_04075	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_04075	COG3321	synthase
OM953_04095	COG0366	Alpha amylase catalytic
OM953_04125	COG2226	methyltransferase
OM953_04130	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
OM953_04140	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
OM953_04180	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
OM953_04190	COG4106	trans-aconitate 2-methyltransferase activity
OM953_04195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OM953_04205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OM953_04210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OM953_04215	COG0667	Aldo Keto reductase
OM953_04225	COG4771	TonB-dependent receptor
OM953_04245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OM953_04250	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
OM953_04260	COG2175	clavaminate synthase activity
OM953_04270	COG4181	ATPase activity
OM953_04285	COG0642	Histidine kinase
OM953_04295	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
OM953_04315	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
OM953_04320	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
OM953_04335	COG3829	transcription factor binding
OM953_04345	COG1116	anion transmembrane transporter activity
OM953_04350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OM953_04360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OM953_04365	COG0431	NADPH-dependent FMN reductase
OM953_04390	COG0747	negative chemotaxis
OM953_04400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OM953_04410	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OM953_04415	COG2967	ApaG domain
OM953_04420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OM953_04425	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
OM953_04430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OM953_04435	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
OM953_04450	COG0123	including yeast histone deacetylase and acetoin utilization protein
OM953_04455	COG2096	Adenosyltransferase
OM953_04470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OM953_04475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OM953_04505	COG3384	dioxygenase
OM953_04510	COG0583	DNA-binding transcription factor activity
OM953_04525	COG1024	Enoyl-CoA hydratase
OM953_04555	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
OM953_04580	COG0697	spore germination
OM953_04590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OM953_04615	COG2197	response regulator
OM953_04625	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OM953_04635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OM953_04640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OM953_04645	COG0583	DNA-binding transcription factor activity
OM953_04650	COG3634	alkyl hydroperoxide reductase activity
OM953_04660	COG2890	protein-(glutamine-N5) methyltransferase activity
OM953_04685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OM953_04685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OM953_04715	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
OM953_04755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OM953_04765	COG1404	Belongs to the peptidase S8 family
OM953_04770	COG1404	Belongs to the peptidase S8 family
OM953_04775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OM953_04800	COG1295	ribonuclease BN
OM953_04805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OM953_04810	COG1254	Belongs to the acylphosphatase family
OM953_04825	COG0521	Mo-molybdopterin cofactor biosynthetic process
OM953_04835	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
OM953_04840	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
OM953_04850	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
OM953_04855	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
OM953_04865	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OM953_04875	COG0193	aminoacyl-tRNA hydrolase activity
OM953_04880	COG0012	GTP binding
OM953_04900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OM953_04915	COG0250	Participates in transcription elongation, termination and antitermination
OM953_04920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
OM953_04925	COG0081	regulation of translation
OM953_04930	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
OM953_04935	COG0222	ribosome binding
OM953_04940	COG0085	RNA polymerase activity
OM953_04945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
OM953_04950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
OM953_04955	COG0049	tRNA binding
OM953_04960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OM953_04965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OM953_04970	COG0051	transcription antitermination factor activity, RNA binding
OM953_04975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
OM953_04980	COG0088	Forms part of the polypeptide exit tunnel
OM953_04985	COG0089	rRNA binding
OM953_04990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
OM953_04995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OM953_05005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
OM953_05010	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
OM953_05015	COG0255	Belongs to the universal ribosomal protein uL29 family
OM953_05020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
OM953_05030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
OM953_05035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
OM953_05040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OM953_05045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
OM953_05050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
OM953_05055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
OM953_05065	COG1841	ribosomal large subunit assembly
OM953_05070	COG0200	Binds to the 23S rRNA
OM953_05075	COG0201	protein transport
OM953_05100	COG0203	ribosomal protein L17
OM953_05105	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
OM953_05120	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
OM953_05135	COG0154	amidase activity
OM953_05145	COG1217	gtp-binding protein TYPA
OM953_05150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OM953_05155	COG0039	L-malate dehydrogenase activity
OM953_05160	COG0625	glutathione transferase activity
OM953_05170	COG1902	pentaerythritol trinitrate reductase activity
OM953_05170	COG0446	pyridine nucleotide-disulphide oxidoreductase
OM953_05175	COG0604	alcohol dehydrogenase
OM953_05200	COG0156	8-amino-7-oxononanoate synthase activity
OM953_05205	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
OM953_05210	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
OM953_05215	COG4208	sulfate ABC transporter
OM953_05220	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
OM953_05250	COG0406	alpha-ribazole phosphatase activity
OM953_05255	COG0285	dihydrofolate synthase activity
OM953_05275	COG2833	Protein of unknown function (DUF455)
OM953_05280	COG3291	Pkd domain containing protein
OM953_05290	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OM953_05295	COG0671	phosphoesterase, PA-phosphatase related
OM953_05300	COG0438	transferase activity, transferring glycosyl groups
OM953_05310	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
OM953_05325	COG4783	chaperone-mediated protein folding
OM953_05340	COG0473	3-isopropylmalate dehydrogenase activity
OM953_05555	COG3179	chitinase
OM953_05600	COG4695	Portal protein
OM953_05625	COG3328	transposase activity
OM953_05645	COG3852	Histidine kinase
OM953_05655	COG0544	peptidyl-prolyl cis-trans isomerase activity
OM953_05665	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
OM953_05695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OM953_05705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OM953_05715	COG0328	RNA-DNA hybrid ribonuclease activity
OM953_05720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OM953_05725	COG0631	protein serine/threonine phosphatase activity
OM953_05740	COG0859	PFAM glycosyl transferase family 9
OM953_05745	COG3642	lipopolysaccharide core region biosynthetic process
OM953_05750	COG1234	tRNA 3'-trailer cleavage
OM953_05755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OM953_05765	COG0315	cyclic pyranopterin monophosphate synthase activity
OM953_05770	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
OM953_05775	COG0314	molybdopterin synthase activity
OM953_05795	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
OM953_05800	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OM953_05805	COG0537	adenosine 5'-monophosphoramidase activity
OM953_05825	COG0714	Associated with various cellular activities
OM953_05850	COG0424	maF-like protein
OM953_05855	COG1399	metal-binding, possibly nucleic acid-binding protein
OM953_05865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OM953_05875	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OM953_05895	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
OM953_05900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OM953_05925	COG3829	transcription factor binding
OM953_05965	COG2373	Large extracellular alpha-helical protein
OM953_05980	COG4953	penicillin-binding protein 1C
OM953_05990	COG0678	peroxiredoxin activity
OM953_06010	COG0330	HflC and HflK could
OM953_06015	COG0330	HflC and HflK could
OM953_06030	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OM953_06035	COG0308	aminopeptidase N
OM953_06045	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_06050	COG1309	transcriptional regulator
OM953_06130	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OM953_06140	COG3387	PFAM Glycoside hydrolase 15-related
OM953_06145	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_06150	COG3537	Alpha-1,2-mannosidase
OM953_06155	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_06170	COG0492	ferredoxin-NADP+ reductase activity
OM953_06200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OM953_06205	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
OM953_06210	COG2080	2 iron, 2 sulfur cluster binding
OM953_06245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OM953_06260	COG0587	DNA-directed DNA polymerase activity
OM953_06280	COG1297	OPT oligopeptide transporter protein
OM953_06295	COG0823	Involved in the tonB-independent uptake of proteins
OM953_06295	COG1506	peptidase
OM953_06310	COG1917	Cupin 2, conserved barrel domain protein
OM953_06310	COG2207	Transcriptional regulator
OM953_06330	COG0753	catalase activity
OM953_06335	COG0656	L-ascorbic acid biosynthetic process
OM953_06345	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OM953_06345	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OM953_06350	COG2814	Major facilitator Superfamily
OM953_06365	COG2194	sulfuric ester hydrolase activity
OM953_06380	COG0745	RESPONSE REGULATOR receiver
OM953_06385	COG0642	Histidine kinase
OM953_06395	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
OM953_06400	COG2894	cell division
OM953_06405	COG0850	regulation of cytokinetic process
OM953_06415	COG4585	Histidine kinase
OM953_06420	COG2197	response regulator
OM953_06435	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
OM953_06460	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
OM953_06470	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
OM953_06490	COG1946	Acyl-CoA thioesterase
OM953_06505	COG0824	Thioesterase
OM953_06510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OM953_06515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
OM953_06520	COG0211	Belongs to the bacterial ribosomal protein bL27 family
OM953_06525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OM953_06530	COG0268	Binds directly to 16S ribosomal RNA
OM953_06540	COG0196	riboflavin kinase activity
OM953_06545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OM953_06550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OM953_06555	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
OM953_06570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OM953_06575	COG1845	cytochrome c oxidase, subunit III
OM953_06580	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OM953_06595	COG3152	Membrane
OM953_06605	COG2207	Transcriptional regulator
OM953_06610	COG0326	Molecular chaperone. Has ATPase activity
OM953_06620	COG1366	Belongs to the anti-sigma-factor antagonist family
OM953_06625	COG1366	Belongs to the anti-sigma-factor antagonist family
OM953_06630	COG2172	sigma factor antagonist activity
OM953_06655	COG4771	TonB-dependent receptor
OM953_06665	COG5507	3-demethylubiquinone-9 3-methyltransferase
OM953_06670	COG2205	protein histidine kinase activity
OM953_06680	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OM953_06685	COG3850	Histidine kinase
OM953_06685	COG4999	Histidine kinase
OM953_06685	COG2205	protein histidine kinase activity
OM953_06685	COG3437	response regulator, receiver
OM953_06690	COG0784	Response regulator, receiver
OM953_06690	COG4191	Histidine kinase
OM953_06730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OM953_06735	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OM953_06745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OM953_06750	COG0228	four-way junction DNA binding
OM953_06755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OM953_06760	COG0336	Belongs to the RNA methyltransferase TrmD family
OM953_06765	COG0335	large ribosomal subunit rRNA binding
OM953_06770	COG0534	Mate efflux family protein
OM953_06790	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
OM953_06800	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
OM953_06810	COG3209	COG3209 Rhs family protein
OM953_06840	COG3250	beta-galactosidase activity
OM953_06845	COG3867	Arabinogalactan endo-beta-1,4-galactanase
OM953_06865	COG1960	acyl-CoA dehydrogenase activity
OM953_06870	COG1024	Enoyl-CoA hydratase
OM953_06915	COG1250	3-hydroxyacyl-CoA dehydrogenase
OM953_06915	COG1024	Enoyl-CoA hydratase
OM953_06930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OM953_06935	COG0481	GTPase activity
OM953_06950	COG0571	ribonuclease III activity
OM953_06955	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OM953_06960	COG1381	Involved in DNA repair and RecF pathway recombination
OM953_06970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OM953_06975	COG2954	triphosphatase activity
OM953_06980	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OM953_06985	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
OM953_06990	COG3046	protein related to deoxyribodipyrimidine photolyase
OM953_06995	COG1472	Belongs to the glycosyl hydrolase 3 family
OM953_07000	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
OM953_07005	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
OM953_07010	COG1278	Cold shock
OM953_07015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OM953_07025	COG1201	RNA secondary structure unwinding
OM953_07030	COG1793	dna ligase
OM953_07040	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
OM953_07040	COG1793	dna ligase
OM953_07075	COG0183	Belongs to the thiolase family
OM953_07100	COG1451	nucleotide metabolic process
OM953_07105	COG5487	UPF0391 membrane protein
OM953_07115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OM953_07130	COG1077	Cell shape determining protein MreB Mrl
OM953_07175	COG0514	ATP-dependent DNA helicase (RecQ)
OM953_07180	COG0783	Belongs to the Dps family
OM953_07185	COG1643	Atp-dependent helicase
OM953_07200	COG0837	glucose binding
OM953_07215	COG0535	radical SAM domain protein
OM953_07220	COG0535	radical SAM domain protein
OM953_07225	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
OM953_07230	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
OM953_07240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OM953_07250	COG1442	glycosyl transferase family 8
OM953_07250	COG1216	Glycosyl transferase, family 2
OM953_07255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OM953_07265	COG1199	ATP-dependent helicase activity
OM953_07275	COG1397	ADP-ribosylglycohydrolase
OM953_07285	COG0189	ligase activity
OM953_07300	COG0835	chemotaxis
OM953_07305	COG0840	transmembrane signaling receptor activity
OM953_07310	COG0784	Response regulator, receiver
OM953_07310	COG0643	Histidine kinase
OM953_07310	COG2198	Histidine kinase
OM953_07330	COG1446	asparaginase
OM953_07335	COG3142	Participates in the control of copper homeostasis
OM953_07370	COG3537	Alpha-1,2-mannosidase
OM953_07380	COG1486	melibiose metabolic process
OM953_07390	COG0531	amino acid
OM953_07405	COG1472	Belongs to the glycosyl hydrolase 3 family
OM953_07415	COG3525	Glycosyl hydrolase, family 20, catalytic domain
OM953_07420	COG1388	LysM domain
OM953_07420	COG3858	chitin binding
OM953_07435	COG0837	glucose binding
OM953_07440	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OM953_07450	COG0494	nUDIX hydrolase
OM953_07455	COG1218	3'(2'),5'-bisphosphate nucleotidase
OM953_07460	COG3956	TIGRFAM MazG family protein
OM953_07465	COG1742	UPF0060 membrane protein
OM953_07485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OM953_07490	COG0509	glycine decarboxylation via glycine cleavage system
OM953_07520	COG1960	acyl-CoA dehydrogenase activity
OM953_07530	COG1309	transcriptional regulator
OM953_07540	COG3328	transposase activity
OM953_07555	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
OM953_07560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OM953_07565	COG0463	Glycosyl transferase, family 2
OM953_07570	COG0516	GMP reductase activity
OM953_07570	COG0517	IMP dehydrogenase activity
OM953_07575	COG2982	Protein involved in outer membrane biogenesis
OM953_07580	COG1272	protein, Hemolysin III
OM953_07585	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OM953_07590	COG0739	heme binding
OM953_07595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OM953_07600	COG0626	cystathionine gamma-synthase activity
OM953_07605	COG0460	homoserine dehydrogenase
OM953_07605	COG0527	aspartate kinase activity
OM953_07615	COG1760	l-serine dehydratase
OM953_07635	COG2353	YceI-like domain
OM953_07640	COG2205	protein histidine kinase activity
OM953_07640	COG0784	Response regulator, receiver
OM953_07640	COG2198	Histidine kinase
OM953_07660	COG2814	Major facilitator Superfamily
OM953_07665	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
OM953_07675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
OM953_07680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OM953_07685	COG0259	pyridoxamine-phosphate oxidase activity
OM953_07695	COG1842	Phage shock protein A
OM953_07720	COG0754	glutathionylspermidine amidase activity
OM953_07730	COG2814	Major facilitator Superfamily
OM953_07760	COG3328	transposase activity
OM953_07810	COG0531	amino acid
OM953_07815	COG2197	response regulator
OM953_07835	COG1113	amino acid transport
OM953_07845	COG1271	oxidase subunit
OM953_07850	COG1294	oxidase, subunit
OM953_07860	COG2239	Acts as a magnesium transporter
OM953_07865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OM953_07870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OM953_07880	COG1660	Displays ATPase and GTPase activities
OM953_07885	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
OM953_07890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OM953_07905	COG1137	ATPase activity
OM953_07910	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
OM953_07920	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
OM953_07930	COG0271	Belongs to the BolA IbaG family
OM953_07935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OM953_07955	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OM953_07965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
OM953_07975	COG0628	permease
OM953_07985	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
OM953_07990	COG3178	'Phosphotransferase
OM953_08005	COG1555	photosystem II stabilization
OM953_08015	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OM953_08020	COG1477	protein flavinylation
OM953_08045	COG3128	pkhd-type hydroxylase
OM953_08055	COG2146	nitrite reductase [NAD(P)H] activity
OM953_08065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OM953_08070	COG0719	Fe-S assembly protein
OM953_08075	COG0396	ATPase activity
OM953_08080	COG0719	Fe-S assembly protein
OM953_08085	COG1959	2 iron, 2 sulfur cluster binding
OM953_08095	COG0693	protein deglycase activity
OM953_08115	COG0739	heme binding
OM953_08130	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
OM953_08155	COG0519	Catalyzes the synthesis of GMP from XMP
OM953_08160	COG1678	Uncharacterized ACR, COG1678
OM953_08165	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OM953_08170	COG0540	Belongs to the ATCase OTCase family
OM953_08175	COG1764	response to oxidative stress
OM953_08185	COG0384	phenazine biosynthesis protein PhzF
OM953_08190	COG0384	phenazine biosynthesis protein PhzF
OM953_08195	COG0527	aspartate kinase activity
OM953_08210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
OM953_08225	COG0142	geranyltranstransferase activity
OM953_08230	COG0629	single-stranded DNA binding
OM953_08240	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_08240	COG0604	alcohol dehydrogenase
OM953_08240	COG3321	synthase
OM953_08245	COG2080	2 iron, 2 sulfur cluster binding
OM953_08250	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
OM953_08255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OM953_08260	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
OM953_08295	COG2879	small protein
OM953_08300	COG1966	Carbon starvation protein
OM953_08305	COG1741	Belongs to the pirin family
OM953_08320	COG1741	Belongs to the pirin family
OM953_08330	COG1515	deoxyribonuclease V activity
OM953_08335	COG0588	phosphoglycerate mutase activity
OM953_08345	COG3590	peptidase
OM953_08350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OM953_08360	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OM953_08365	COG2199	diguanylate cyclase activity
OM953_08365	COG2200	EAL domain
OM953_08365	COG2202	Pas domain
OM953_08370	COG0835	chemotaxis
OM953_08375	COG0840	transmembrane signaling receptor activity
OM953_08380	COG2198	Histidine kinase
OM953_08380	COG0643	Histidine kinase
OM953_08390	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OM953_08400	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
OM953_08405	COG0745	RESPONSE REGULATOR receiver
OM953_08410	COG2205	protein histidine kinase activity
OM953_08420	COG4452	Inner membrane protein CreD
OM953_08445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OM953_08450	COG0735	belongs to the Fur family
OM953_08465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OM953_08475	COG1309	transcriptional regulator
OM953_08485	COG2207	Transcriptional regulator
OM953_08495	COG0583	DNA-binding transcription factor activity
OM953_08500	COG2814	Major facilitator Superfamily
OM953_08505	COG0667	Aldo Keto reductase
OM953_08550	COG2951	lytic endotransglycosylase activity
OM953_08650	COG1595	DNA-templated transcription, initiation
OM953_08660	COG5002	protein histidine kinase activity
OM953_08660	COG5001	Diguanylate cyclase
OM953_08665	COG1187	pseudouridine synthase activity
OM953_08685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OM953_08695	COG0475	glutathione-regulated potassium exporter activity
OM953_08700	COG5000	phosphorelay sensor kinase activity
OM953_08700	COG5002	protein histidine kinase activity
OM953_08705	COG0745	RESPONSE REGULATOR receiver
OM953_08710	COG1538	Outer membrane efflux protein
OM953_08735	COG1132	(ABC) transporter
OM953_08780	COG2155	Conserved Protein
OM953_08820	COG3118	belongs to the thioredoxin family
OM953_08830	COG0495	leucyl-tRNA aminoacylation
OM953_08845	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OM953_08860	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
OM953_08875	COG2968	Membrane
OM953_08880	COG0424	maF-like protein
OM953_08890	COG3164	Protein of unknown function
OM953_08900	COG0312	modulator of DNA gyrase
OM953_08905	COG3028	Belongs to the UPF0307 family
OM953_08910	COG0312	modulator of DNA gyrase
OM953_08920	COG4104	PAAR repeat-containing protein
OM953_08925	COG0142	geranyltranstransferase activity
OM953_08930	COG1722	exodeoxyribonuclease VII activity
OM953_08935	COG0037	tRNA processing
OM953_08940	COG1785	Belongs to the alkaline phosphatase family
OM953_08945	COG1301	dicarboxylic acid transport
OM953_08950	COG4106	trans-aconitate 2-methyltransferase activity
OM953_08960	COG0791	NLP P60 protein
OM953_08965	COG0791	NLP P60 protein
OM953_08970	COG1047	Peptidyl-prolyl cis-trans
OM953_08975	COG2311	Membrane
OM953_08980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OM953_08985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OM953_09005	COG3590	peptidase
OM953_09010	COG3590	peptidase
OM953_09030	COG0489	protein tyrosine kinase activity
OM953_09035	COG0717	Belongs to the dCTP deaminase family
OM953_09060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OM953_09065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OM953_09080	COG0494	nUDIX hydrolase
OM953_09085	COG0433	COG0433 Predicted ATPase
OM953_09095	COG0688	phosphatidylethanolamine metabolic process
OM953_09105	COG2890	protein-(glutamine-N5) methyltransferase activity
OM953_09110	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
OM953_09115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OM953_09120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OM953_09135	COG0101	tRNA pseudouridine synthase activity
OM953_09140	COG0135	phosphoribosylanthranilate isomerase activity
OM953_09150	COG0133	tryptophan synthase activity
OM953_09160	COG0159	tryptophan synthase activity
OM953_09165	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
OM953_09170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OM953_09200	COG0300	oxidoreductase activity
OM953_09205	COG0149	triose-phosphate isomerase activity
OM953_09220	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OM953_09225	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OM953_09230	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OM953_09235	COG0649	NAD binding
OM953_09240	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
OM953_09245	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
OM953_09255	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
OM953_09260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OM953_09285	COG1007	ATP synthesis coupled electron transport
OM953_09295	COG0779	Required for maturation of 30S ribosomal subunits
OM953_09300	COG0195	Participates in both transcription termination and antitermination
OM953_09305	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
OM953_09310	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
OM953_09315	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OM953_09320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
OM953_09325	COG1185	polyribonucleotide nucleotidyltransferase activity
OM953_09360	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OM953_09370	COG2095	MarC family integral membrane protein
OM953_09380	COG1611	Belongs to the LOG family
OM953_09385	COG4969	Belongs to the N-Me-Phe pilin family
OM953_09420	COG4969	Belongs to the N-Me-Phe pilin family
OM953_09425	COG0556	nucleotide-excision repair
OM953_09545	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
OM953_09555	COG0582	viral genome integration into host DNA
OM953_09565	COG3505	Type IV secretory pathway VirD4
OM953_09585	COG2948	multi-organism process
OM953_09605	COG3702	type iv secretory pathway
OM953_09640	COG0366	Alpha amylase catalytic
OM953_09655	COG1082	Xylose isomerase domain protein TIM barrel
OM953_09665	COG2211	Major facilitator Superfamily
OM953_09665	COG2190	(PTS) system
OM953_09680	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
OM953_09685	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
OM953_09700	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
OM953_09705	COG0072	phenylalanine-tRNA ligase activity
OM953_09705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OM953_09755	COG0438	transferase activity, transferring glycosyl groups
OM953_09760	COG0438	transferase activity, transferring glycosyl groups
OM953_09770	COG0438	transferase activity, transferring glycosyl groups
OM953_09795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OM953_09800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OM953_09805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OM953_09825	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
OM953_09835	COG1960	acyl-CoA dehydrogenase activity
OM953_09845	COG3040	lipid binding
OM953_09860	COG0322	excinuclease ABC activity
OM953_09875	COG0784	Response regulator, receiver
OM953_09875	COG4191	Histidine kinase
OM953_09880	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
OM953_09885	COG1194	a g-specific adenine glycosylase
OM953_09900	COG3938	Belongs to the proline racemase family
OM953_09905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OM953_09920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OM953_09930	COG0006	proline dipeptidase activity
OM953_09945	COG0531	amino acid
OM953_10050	COG0326	Molecular chaperone. Has ATPase activity
OM953_10055	COG0742	ribosomal rna small subunit methyltransferase
OM953_10060	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
OM953_10070	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OM953_10075	COG0405	Gamma-glutamyltransferase
OM953_10080	COG3291	Pkd domain containing protein
OM953_10085	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
OM953_10120	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
OM953_10125	COG0343	queuine tRNA-ribosyltransferase activity
OM953_10130	COG1862	Preprotein translocase
OM953_10140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OM953_10170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OM953_10170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OM953_10175	COG1105	Belongs to the carbohydrate kinase PfkB family
OM953_10180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OM953_10180	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OM953_10185	COG1609	Transcriptional regulator
OM953_10190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OM953_10195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OM953_10205	COG2902	Dehydrogenase
OM953_10210	COG0477	Major facilitator Superfamily
OM953_10225	COG0784	Response regulator, receiver
OM953_10225	COG2205	protein histidine kinase activity
OM953_10225	COG5002	protein histidine kinase activity
OM953_10230	COG2733	membrane
OM953_10240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OM953_10245	COG2223	nitrite transmembrane transporter activity
OM953_10250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OM953_10255	COG0243	molybdopterin cofactor binding
OM953_10265	COG0477	Major facilitator Superfamily
OM953_10270	COG2703	oxygen carrier activity
OM953_10280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OM953_10285	COG0174	glutamine synthetase
OM953_10305	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
OM953_10325	COG3842	ATPase activity
OM953_10335	COG1176	ABC-type spermidine putrescine transport system, permease component I
OM953_10340	COG1177	transmembrane transport
OM953_10345	COG1012	belongs to the aldehyde dehydrogenase family
OM953_10360	COG4535	Mg2 and Co2 transporter CorC
OM953_10370	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
OM953_10380	COG1702	phosphate starvation-inducible protein PhoH
OM953_10385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OM953_10400	COG0741	lytic transglycosylase activity
OM953_10405	COG0723	plastoquinol--plastocyanin reductase activity
OM953_10410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
OM953_10415	COG2857	Cytochrome c1
OM953_10420	COG0625	glutathione transferase activity
OM953_10425	COG2969	positive regulation of protein catabolic process
OM953_10445	COG1201	RNA secondary structure unwinding
OM953_10450	COG2094	Belongs to the DNA glycosylase MPG family
OM953_10455	COG0840	transmembrane signaling receptor activity
OM953_10460	COG0835	chemotaxis
OM953_10500	COG3723	Recombinational DNA repair protein, rece pathway
OM953_10590	COG0305	Participates in initiation and elongation during chromosome replication
OM953_10625	COG3328	transposase activity
OM953_10795	COG0582	viral genome integration into host DNA
OM953_10830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OM953_10840	COG1570	exodeoxyribonuclease VII activity
OM953_10845	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
OM953_10850	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OM953_10850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OM953_10855	COG0802	atpase or kinase
OM953_10860	COG0860	N-Acetylmuramoyl-L-alanine amidase
OM953_10865	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OM953_10890	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_10895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OM953_10900	COG0501	Belongs to the peptidase M48B family
OM953_10910	COG2081	HI0933 family
OM953_10915	COG4681	YaeQ
OM953_10925	COG0625	glutathione transferase activity
OM953_10935	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
OM953_10940	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OM953_10945	COG0513	Belongs to the DEAD box helicase family
OM953_10950	COG0488	(ABC) transporter
OM953_10965	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OM953_10970	COG0483	inositol monophosphate 1-phosphatase activity
OM953_10985	COG5001	Diguanylate cyclase
OM953_10985	COG3300	MHYT domain
OM953_10995	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OM953_11005	COG0402	S-adenosylhomocysteine deaminase activity
OM953_11010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OM953_11065	COG4302	ethanolamine ammonia-lyase activity
OM953_11085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OM953_11090	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
OM953_11105	COG2166	iron-sulfur cluster assembly
OM953_11110	COG0215	cysteine-tRNA ligase activity
OM953_11120	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
OM953_11125	COG0137	argininosuccinate synthase activity
OM953_11135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OM953_11140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OM953_11150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
OM953_11155	COG0165	Argininosuccinate lyase
OM953_11165	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OM953_11170	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
OM953_11200	COG1294	oxidase, subunit
OM953_11210	COG4988	ABC transporter
OM953_11215	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
OM953_11220	COG1278	Cold shock
OM953_11225	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OM953_11245	COG1138	Cytochrome C-type biogenesis protein
OM953_11250	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
OM953_11270	COG4133	protoheme IX ABC transporter activity
OM953_11275	COG0436	Aminotransferase
OM953_11295	COG1187	pseudouridine synthase activity
OM953_11300	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
OM953_11305	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
OM953_11310	COG2350	Protein conserved in bacteria
OM953_11340	COG1175	transmembrane transport
OM953_11345	COG0395	ABC-type sugar transport system, permease component
OM953_11370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OM953_11375	COG2957	Belongs to the agmatine deiminase family
OM953_11390	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
OM953_11395	COG0539	negative regulation of cytoplasmic translation
OM953_11400	COG0776	regulation of translation
OM953_11410	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
OM953_11415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OM953_11425	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OM953_11430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OM953_11430	COG0475	glutathione-regulated potassium exporter activity
OM953_11440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
OM953_11450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OM953_11450	COG0519	Catalyzes the synthesis of GMP from XMP
OM953_11455	COG3002	Belongs to the UPF0753 family
OM953_11460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OM953_11465	COG0583	DNA-binding transcription factor activity
OM953_11480	COG2197	response regulator
OM953_11500	COG1335	isochorismatase
OM953_11515	COG2814	Major facilitator Superfamily
OM953_11530	COG1648	precorrin-2 dehydrogenase activity
OM953_11530	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OM953_11545	COG3685	Protein conserved in bacteria
OM953_11565	COG5001	Diguanylate cyclase
OM953_11575	COG4566	intracellular signal transduction
OM953_11615	COG3275	phosphorelay sensor kinase activity
OM953_11620	COG3279	Response regulator of the LytR AlgR family
OM953_11655	COG1238	metal cluster binding
OM953_11665	COG3920	Histidine kinase
OM953_11695	COG3220	belongs to the UPF0276 family
OM953_11720	COG2951	lytic endotransglycosylase activity
OM953_11750	COG5599	Phosphatase
OM953_11760	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_11765	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
OM953_11770	COG2226	methyltransferase
OM953_11770	COG1073	alpha beta
OM953_11815	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
OM953_11815	COG0316	Belongs to the HesB IscA family
OM953_11820	COG2154	pterin-4-alpha-carbinolamine dehydratase
OM953_11830	COG0428	transporter
OM953_11835	COG3064	Membrane
OM953_11845	COG1530	ribonuclease E activity
OM953_11855	COG1054	Belongs to the UPF0176 family
OM953_11875	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
OM953_11900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OM953_11905	COG0322	excinuclease ABC activity
OM953_11915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OM953_11920	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
OM953_11925	COG1663	tetraacyldisaccharide 4'-kinase activity
OM953_11930	COG1132	(ABC) transporter
OM953_11935	COG0848	biopolymer transport protein
OM953_11940	COG0811	peptide transport
OM953_11955	COG1136	(ABC) transporter
OM953_11960	COG4591	ABC-type transport system involved in lipoprotein release permease component
OM953_11970	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
OM953_11975	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OM953_11990	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
OM953_12005	COG0354	folic acid binding
OM953_12015	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OM953_12020	COG0837	glucose binding
OM953_12025	COG0363	glucosamine-6-phosphate deaminase activity
OM953_12030	COG0129	dihydroxy-acid dehydratase activity
OM953_12035	COG0800	Aldolase
OM953_12040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OM953_12100	COG0784	Response regulator, receiver
OM953_12100	COG2205	protein histidine kinase activity
OM953_12105	COG2183	response to ionizing radiation
OM953_12115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OM953_12115	COG0723	plastoquinol--plastocyanin reductase activity
OM953_12130	COG3243	poly(R)-hydroxyalkanoic acid synthase
OM953_12140	COG1183	phosphatidylcholine synthase activity
OM953_12145	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_12160	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
OM953_12170	COG0668	transmembrane transport
OM953_12175	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
OM953_12190	COG1914	H( )-stimulated, divalent metal cation uptake system
OM953_12220	COG0746	molybdenum cofactor guanylyltransferase activity
OM953_12225	COG0303	'Molybdopterin
OM953_12235	COG0708	Exodeoxyribonuclease III
OM953_12275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OM953_12280	COG0303	'Molybdopterin
OM953_12285	COG1160	GTP binding
OM953_12290	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OM953_12300	COG1426	Protein conserved in bacteria
OM953_12310	COG0820	rRNA (adenine-C2-)-methyltransferase activity
OM953_12325	COG1250	3-hydroxyacyl-CoA dehydrogenase
OM953_12325	COG1024	Enoyl-CoA hydratase
OM953_12330	COG0183	Belongs to the thiolase family
OM953_12335	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OM953_12340	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OM953_12350	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OM953_12360	COG1674	ftsk spoiiie
OM953_12365	COG0492	ferredoxin-NADP+ reductase activity
OM953_12375	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
OM953_12385	COG0542	response to heat
OM953_12400	COG0482	sulfurtransferase activity
OM953_12405	COG2915	High frequency lysogenization protein hflD homolog
OM953_12440	COG5002	protein histidine kinase activity
OM953_12465	COG0784	Response regulator, receiver
OM953_12465	COG0835	chemotaxis
OM953_12475	COG1558	bacterial-type flagellum-dependent cell motility
OM953_12480	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
OM953_12490	COG4787	bacterial-type flagellum-dependent cell motility
OM953_12500	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
OM953_12505	COG1706	bacterial-type flagellum-dependent cell motility
OM953_12510	COG3951	Flagellar rod assembly protein muramidase FlgJ
OM953_12510	COG1705	Flagellar rod assembly protein muramidase FlgJ
OM953_12520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OM953_12535	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
OM953_12565	COG2201	protein-glutamate methylesterase activity
OM953_12585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OM953_12590	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_12595	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_12630	COG1677	Flagellar hook-basal body complex protein FliE
OM953_12680	COG3190	flagellar
OM953_12695	COG1684	flagellar biosynthetic protein fliR
OM953_12750	COG0643	Histidine kinase
OM953_12750	COG0784	Response regulator, receiver
OM953_12750	COG2198	Histidine kinase
OM953_12825	COG1192	Involved in chromosome partitioning
OM953_12840	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
OM953_12845	COG1360	Flagellar Motor Protein
OM953_12855	COG0835	chemotaxis
OM953_12865	COG0745	RESPONSE REGULATOR receiver
OM953_12890	COG0840	transmembrane signaling receptor activity
OM953_12900	COG0840	transmembrane signaling receptor activity
OM953_12905	COG0840	transmembrane signaling receptor activity
OM953_12910	COG0840	transmembrane signaling receptor activity
OM953_12915	COG0840	transmembrane signaling receptor activity
OM953_12925	COG0840	transmembrane signaling receptor activity
OM953_12935	COG0840	transmembrane signaling receptor activity
OM953_12940	COG0840	transmembrane signaling receptor activity
OM953_12960	COG0835	chemotaxis
OM953_12975	COG0840	transmembrane signaling receptor activity
OM953_12985	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
OM953_12990	COG2201	protein-glutamate methylesterase activity
OM953_13000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OM953_13030	COG0318	PFAM AMP-dependent synthetase and ligase
OM953_13035	COG1024	Enoyl-CoA hydratase
OM953_13040	COG2198	Histidine kinase
OM953_13040	COG0784	Response regulator, receiver
OM953_13040	COG2205	protein histidine kinase activity
OM953_13045	COG0784	Response regulator, receiver
OM953_13045	COG2198	Histidine kinase
OM953_13045	COG2205	protein histidine kinase activity
OM953_13055	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
OM953_13065	COG3279	Response regulator of the LytR AlgR family
OM953_13075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OM953_13085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OM953_13090	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
OM953_13100	COG0505	Belongs to the CarA family
OM953_13105	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
OM953_13115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OM953_13160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OM953_13180	COG0277	FAD linked oxidase domain protein
OM953_13185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OM953_13195	COG0531	amino acid
OM953_13200	COG0531	amino acid
OM953_13205	COG0235	Class ii aldolase
OM953_13210	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
OM953_13215	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
OM953_13230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OM953_13230	COG0140	phosphoribosyl-ATP diphosphatase activity
OM953_13235	COG0107	imidazoleglycerol-phosphate synthase activity
OM953_13240	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
OM953_13245	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OM953_13250	COG0131	Imidazoleglycerol-phosphate dehydratase
OM953_13250	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
OM953_13255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OM953_13260	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OM953_13265	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OM953_13275	COG0124	histidyl-tRNA synthetase
OM953_13280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OM953_13290	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
OM953_13345	COG0726	polysaccharide deacetylase
OM953_13345	COG1649	PFAM Uncharacterised BCR, COG1649
OM953_13350	COG1215	transferase activity, transferring glycosyl groups
OM953_13390	COG1012	belongs to the aldehyde dehydrogenase family
OM953_13410	COG0167	dihydroorotate dehydrogenase activity
OM953_13415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
OM953_13420	COG0697	spore germination
OM953_13425	COG1794	racemase activity, acting on amino acids and derivatives
OM953_13440	COG0671	phosphoesterase, PA-phosphatase related
OM953_13445	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
OM953_13455	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
OM953_13460	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
OM953_13465	COG2203	Gaf domain
OM953_13465	COG3706	GGDEF domain
OM953_13465	COG4251	negative regulation of phosphorylation
OM953_13465	COG5001	Diguanylate cyclase
OM953_13475	COG1472	Belongs to the glycosyl hydrolase 3 family
OM953_13500	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
OM953_13505	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
OM953_13510	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
OM953_13530	COG1469	GTP cyclohydrolase I activity
OM953_13535	COG0860	N-Acetylmuramoyl-L-alanine amidase
OM953_13550	COG0477	Major facilitator Superfamily
OM953_13555	COG2115	Belongs to the xylose isomerase family
OM953_13560	COG1070	Carbohydrate kinase
OM953_13570	COG1501	Belongs to the glycosyl hydrolase 31 family
OM953_13605	COG0800	Aldolase
OM953_13610	COG4948	Mandelate Racemase Muconate Lactonizing
OM953_13620	COG3734	2-keto-3-deoxy-galactonokinase
OM953_13625	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
OM953_13635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OM953_13650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
OM953_13655	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
OM953_13670	COG0351	phosphomethylpyrimidine kinase
OM953_13695	COG0583	DNA-binding transcription factor activity
OM953_13700	COG1741	Belongs to the pirin family
OM953_13720	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
OM953_13725	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OM953_13730	COG2137	regulation of response to DNA damage stimulus
OM953_13735	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
OM953_13740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OM953_13750	COG1546	Belongs to the CinA family
OM953_13755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OM953_13765	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
OM953_13770	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OM953_13780	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
OM953_13785	COG1534	Rna-binding protein
OM953_13800	COG1238	metal cluster binding
OM953_13805	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OM953_13810	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
OM953_13815	COG2840	Smr protein MutS2
OM953_13820	COG0585	pseudouridine synthase activity
OM953_13825	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
OM953_13830	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
OM953_13835	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
OM953_13840	COG0148	phosphopyruvate hydratase activity
OM953_13855	COG0504	CTP synthase activity
OM953_13880	COG0306	phosphate transporter
OM953_13890	COG1253	flavin adenine dinucleotide binding
OM953_13905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OM953_13910	COG0477	Major facilitator Superfamily
OM953_13920	COG1136	(ABC) transporter
OM953_13945	COG2264	protein methyltransferase activity
OM953_13970	COG3328	transposase activity
OM953_13985	COG2244	polysaccharide biosynthetic process
OM953_14035	COG1595	DNA-templated transcription, initiation
OM953_14050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OM953_14060	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
OM953_14070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OM953_14085	COG0784	Response regulator, receiver
OM953_14085	COG4191	Histidine kinase
OM953_14090	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
OM953_14115	COG0840	transmembrane signaling receptor activity
OM953_14130	COG0583	DNA-binding transcription factor activity
OM953_14135	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OM953_14140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
OM953_14155	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OM953_14160	COG0077	Prephenate dehydratase
OM953_14160	COG1605	Chorismate mutase
OM953_14170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
OM953_14175	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
OM953_14210	COG1228	amidohydrolase
OM953_14215	COG2986	histidine ammonia-lyase
OM953_14225	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
OM953_14235	COG4993	Dehydrogenase
OM953_14245	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
OM953_14260	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
OM953_14265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OM953_14270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OM953_14280	COG3115	cell septum assembly
OM953_14295	COG0359	binds to the 23S rRNA
OM953_14300	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
OM953_14305	COG0360	Binds together with S18 to 16S ribosomal RNA
OM953_14310	COG0316	Belongs to the HesB IscA family
OM953_14315	COG0017	Asparaginyl-tRNA synthetase
OM953_14395	COG0288	reversible hydration of carbon dioxide
OM953_14400	COG0662	Cupin 2, conserved barrel domain protein
OM953_14410	COG3844	kynureninase activity
OM953_14415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OM953_14420	COG2925	Exonuclease
OM953_14445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OM953_14495	COG0494	nUDIX hydrolase
OM953_14505	COG1024	Enoyl-CoA hydratase
OM953_14515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OM953_14520	COG0659	secondary active sulfate transmembrane transporter activity
OM953_14545	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OM953_14550	COG0573	inorganic phosphate transmembrane transporter activity
OM953_14555	COG0581	inorganic phosphate transmembrane transporter activity
OM953_14560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OM953_14565	COG0704	Plays a role in the regulation of phosphate uptake
OM953_14575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OM953_14585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OM953_14595	COG0557	exoribonuclease II activity
OM953_14610	COG1960	acyl-CoA dehydrogenase activity
OM953_14615	COG2226	methyltransferase
OM953_14620	COG0646	methionine synthase
OM953_14620	COG1410	methionine synthase
OM953_14625	COG0646	methionine synthase
OM953_14625	COG1410	methionine synthase
OM953_14635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OM953_14660	COG2900	Belongs to the SlyX family
OM953_14675	COG0386	Belongs to the glutathione peroxidase family
OM953_14685	COG1725	Transcriptional regulator
OM953_14690	COG1131	(ABC) transporter
OM953_14720	COG1253	flavin adenine dinucleotide binding
OM953_14740	COG2850	peptidyl-arginine hydroxylation
OM953_14750	COG0567	Dehydrogenase, E1 component
OM953_14775	COG1132	(ABC) transporter
OM953_14780	COG0583	DNA-binding transcription factor activity
OM953_14810	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
OM953_14815	COG0484	heat shock protein binding
OM953_14820	COG0443	Heat shock 70 kDa protein
OM953_14825	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OM953_14830	COG1420	regulation of RNA biosynthetic process
OM953_14835	COG0497	DNA recombination
OM953_14845	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OM953_14860	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
OM953_14950	COG3328	transposase activity
OM953_15055	COG3706	GGDEF domain
OM953_15100	COG0583	DNA-binding transcription factor activity
OM953_15110	COG0415	Belongs to the DNA photolyase family
OM953_15115	COG0305	Participates in initiation and elongation during chromosome replication
OM953_15125	COG0367	asparagine synthase
OM953_15145	COG1960	acyl-CoA dehydrogenase activity
OM953_15160	COG0084	hydrolase, TatD family'
OM953_15165	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OM953_15220	COG0386	Belongs to the glutathione peroxidase family
OM953_15225	COG0339	signal peptide processing
OM953_15275	COG2814	Major facilitator Superfamily
OM953_15280	COG1566	PFAM secretion protein HlyD family protein
OM953_15310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OM953_15350	COG2801	Transposase and inactivated derivatives
OM953_15355	COG2842	Transposition protein
OM953_15420	COG5566	PFAM Mor transcription activator
OM953_15445	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OM953_15465	COG4373	Mu-like prophage FluMu protein gp28
OM953_15470	COG4383	Mu-like prophage protein gp29
OM953_15475	COG2369	cell adhesion
OM953_15495	COG4397	Mu-like prophage major head subunit gpT
OM953_15580	COG4774	siderophore transport
OM953_15590	COG0367	asparagine synthase
OM953_15595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OM953_15600	COG1393	Belongs to the ArsC family
OM953_15650	COG0052	Belongs to the universal ribosomal protein uS2 family
OM953_15655	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
OM953_15665	COG0528	UMP kinase activity
OM953_15670	COG0233	cytoplasmic translational termination
OM953_15675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OM953_15680	COG0575	Belongs to the CDS family
OM953_15685	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
OM953_15690	COG0750	zinc metalloprotease
OM953_15705	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OM953_15710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OM953_15715	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OM953_15720	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OM953_15735	COG0825	malonyl-CoA metabolic process
OM953_15750	COG1981	membrane
OM953_15770	COG1695	Transcriptional regulator
OM953_15790	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
OM953_15800	COG2040	homocysteine
OM953_15805	COG0833	amino acid
OM953_15810	COG0346	lactoylglutathione lyase activity
OM953_15815	COG1131	(ABC) transporter
OM953_15830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OM953_15830	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OM953_15840	COG2878	Part of a membrane complex involved in electron transport
OM953_15855	COG1595	DNA-templated transcription, initiation
OM953_15880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OM953_15895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OM953_15900	COG0251	oxidation-reduction process
OM953_15910	COG0392	lysyltransferase activity
OM953_15910	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
OM953_15945	COG2814	Major facilitator Superfamily
OM953_15950	COG1902	pentaerythritol trinitrate reductase activity
OM953_15955	COG2824	Alkylphosphonate utilization operon protein PhnA
OM953_15965	COG1047	Peptidyl-prolyl cis-trans
OM953_15990	COG3920	Histidine kinase
OM953_15995	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
OM953_16005	COG0602	queuosine metabolic process
OM953_16015	COG2885	chlorophyll binding
OM953_16020	COG0823	Involved in the tonB-independent uptake of proteins
OM953_16030	COG0848	biopolymer transport protein
OM953_16040	COG0824	Thioesterase
OM953_16045	COG2255	four-way junction helicase activity
OM953_16050	COG3158	transport of potassium into the cell
OM953_16055	COG0632	four-way junction helicase activity
OM953_16060	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
OM953_16065	COG0217	transcriptional regulatory protein
OM953_16080	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
OM953_16095	COG0477	Major facilitator Superfamily
OM953_16135	COG0488	(ABC) transporter
OM953_16165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OM953_16165	COG4651	solute:proton antiporter activity
OM953_16175	COG4772	TonB-dependent receptor
OM953_16185	COG4264	IucA IucC family
OM953_16200	COG0019	diaminopimelate decarboxylase activity
OM953_16230	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
OM953_16250	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
OM953_16275	COG4206	TonB-dependent receptor
OM953_16280	COG0542	response to heat
OM953_16285	COG1116	anion transmembrane transporter activity
OM953_16290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OM953_16295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OM953_16300	COG0667	Aldo Keto reductase
OM953_16305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OM953_16310	COG4771	TonB-dependent receptor
OM953_16315	COG2827	Endonuclease containing a URI domain
OM953_16355	COG1877	trehalose-phosphatase activity
OM953_16360	COG3387	PFAM Glycoside hydrolase 15-related
OM953_16375	COG0840	transmembrane signaling receptor activity
OM953_16380	COG3011	Protein conserved in bacteria
OM953_16395	COG0564	pseudouridine synthase activity
OM953_16400	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OM953_16410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OM953_16410	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OM953_16425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OM953_16430	COG0045	succinate-CoA ligase (ADP-forming) activity
OM953_16470	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
OM953_16475	COG0237	dephospho-CoA kinase activity
OM953_16505	COG0745	RESPONSE REGULATOR receiver
OM953_16515	COG0189	ligase activity
OM953_16560	COG2022	thiamine diphosphate biosynthetic process
OM953_16565	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OM953_16570	COG0471	metal ion transport
OM953_16570	COG3273	potassium ion transport
OM953_16590	COG1970	mechanosensitive ion channel activity
OM953_16600	COG1609	Transcriptional regulator
OM953_16610	COG3250	beta-galactosidase activity
OM953_16615	COG4948	Mandelate Racemase Muconate Lactonizing
OM953_16625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OM953_16635	COG0308	aminopeptidase N
OM953_16640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OM953_16650	COG2895	sulfate adenylyltransferase (ATP) activity
OM953_16650	COG0529	Catalyzes the synthesis of activated sulfate
OM953_16655	COG0175	sulfate reduction
OM953_16660	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OM953_16665	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OM953_16670	COG0175	sulfate reduction
OM953_16690	COG2205	protein histidine kinase activity
OM953_16690	COG2198	Histidine kinase
OM953_16690	COG0784	Response regulator, receiver
OM953_16705	COG1648	precorrin-2 dehydrogenase activity
OM953_16705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OM953_16720	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
OM953_16725	COG3588	fructose-bisphosphate aldolase
OM953_16730	COG0469	pyruvate kinase activity
OM953_16740	COG0126	phosphoglycerate kinase activity
OM953_16760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OM953_16770	COG3047	cAMP biosynthetic process
OM953_16775	COG3047	cAMP biosynthetic process
OM953_16785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OM953_16785	COG3453	Protein conserved in bacteria
OM953_16790	COG0725	ABC transporter, periplasmic molybdate-binding protein
OM953_16795	COG4149	molybdate abc transporter
OM953_16800	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
OM953_16835	COG1376	ErfK ybiS ycfS ynhG family protein
OM953_16840	COG0739	heme binding
OM953_16845	COG4773	Receptor
OM953_16855	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OM953_16860	COG1301	dicarboxylic acid transport
OM953_16870	COG2304	oxidoreductase activity
OM953_16890	COG0714	Associated with various cellular activities
OM953_16920	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
OM953_16945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OM953_16955	COG2721	sulfolactate sulfo-lyase activity
OM953_16970	COG2271	Major facilitator Superfamily
OM953_16985	COG0583	DNA-binding transcription factor activity
OM953_16990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OM953_17005	COG1561	YicC-like family, N-terminal region
OM953_17010	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
OM953_17020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
OM953_17025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OM953_17040	COG0006	proline dipeptidase activity
OM953_17050	COG0006	proline dipeptidase activity
OM953_17055	COG3079	Belongs to the UPF0149 family
OM953_17075	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OM953_17085	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
OM953_17095	COG2912	Transglutaminase-like superfamily
OM953_17100	COG1773	rubredoxin
OM953_17105	COG0352	thiamine-phosphate diphosphorylase activity
OM953_17120	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OM953_17135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OM953_17165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OM953_17170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OM953_17175	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_17185	COG0671	phosphoesterase, PA-phosphatase related
OM953_17200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OM953_17205	COG0563	adenylate kinase activity
OM953_17220	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
OM953_17230	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
OM953_17250	COG3710	Transcriptional regulator
OM953_17255	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
OM953_17265	COG0840	transmembrane signaling receptor activity
OM953_17270	COG0405	Gamma-glutamyltransferase
OM953_17275	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
OM953_17295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OM953_17300	COG0473	3-isopropylmalate dehydrogenase activity
OM953_17305	COG0066	3-isopropylmalate dehydratase activity
OM953_17310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
OM953_17330	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OM953_17335	COG1538	Outer membrane efflux protein
OM953_17340	COG1519	Transferase
OM953_17345	COG1560	Kdo2-lipid A biosynthetic process
OM953_17400	COG0280	phosphate acetyltransferase
OM953_17400	COG0281	malic enzyme
OM953_17405	COG1301	dicarboxylic acid transport
OM953_17430	COG0583	DNA-binding transcription factor activity
OM953_17435	COG0667	Aldo Keto reductase
OM953_17450	COG2197	response regulator
OM953_17460	COG0642	Histidine kinase
OM953_17475	COG2851	Citrate transporter
OM953_17480	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_17485	COG1609	Transcriptional regulator
OM953_17490	COG2211	Major facilitator Superfamily
OM953_17520	COG1162	GTPase activity
OM953_17570	COG0436	Aminotransferase
OM953_17585	COG0726	polysaccharide deacetylase
OM953_17590	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OM953_17605	COG3964	amidohydrolase
OM953_17610	COG0402	S-adenosylhomocysteine deaminase activity
OM953_17630	COG1307	EDD domain protein, DegV family
OM953_17635	COG0242	peptide deformylase activity
OM953_17655	COG0457	Tetratricopeptide repeat
OM953_17660	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
OM953_17665	COG1215	transferase activity, transferring glycosyl groups
OM953_17670	COG1215	transferase activity, transferring glycosyl groups
OM953_17685	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
OM953_17730	COG2188	Transcriptional regulator
OM953_17740	COG1450	Type ii and iii secretion system protein
OM953_17755	COG3166	PFAM Fimbrial assembly family protein
OM953_17760	COG3156	type II secretion system protein K
OM953_17765	COG4795	General secretion pathway protein
OM953_17770	COG2165	general secretion pathway protein
OM953_17775	COG4970	Tfp pilus assembly protein FimT
OM953_17780	COG2165	general secretion pathway protein
OM953_17785	COG1459	type II secretion system
OM953_17790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OM953_17795	COG1404	Belongs to the peptidase S8 family
OM953_17800	COG5295	Hep Hag repeat protein
OM953_17805	COG1404	Belongs to the peptidase S8 family
OM953_17810	COG5295	Hep Hag repeat protein
OM953_17820	COG0047	phosphoribosylformylglycinamidine synthase activity
OM953_17820	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OM953_17825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OM953_17830	COG4974	Belongs to the 'phage' integrase family
OM953_17845	COG0795	lipopolysaccharide-transporting ATPase activity
OM953_17855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OM953_17870	COG0525	valine-tRNA ligase activity
OM953_17905	COG1183	phosphatidylcholine synthase activity
OM953_17915	COG0442	prolyl-tRNA aminoacylation
OM953_17930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OM953_17935	COG1127	ABC transporter
OM953_17940	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OM953_17940	COG3218	ABC-type transport auxiliary lipoprotein component
OM953_17975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OM953_17980	COG0662	Cupin 2, conserved barrel domain protein
OM953_17980	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
OM953_18010	COG2086	electron transfer activity
OM953_18025	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
OM953_18025	COG0546	phosphoglycolate phosphatase activity
OM953_18030	COG0277	FAD linked oxidase domain protein
OM953_18045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OM953_18075	COG0438	transferase activity, transferring glycosyl groups
OM953_18075	COG1216	Glycosyl transferase, family 2
OM953_18095	COG0626	cystathionine gamma-synthase activity
OM953_18125	COG0625	glutathione transferase activity
OM953_18135	COG0513	Belongs to the DEAD box helicase family
OM953_18145	COG4771	TonB-dependent receptor
OM953_18150	COG0720	synthase
OM953_18175	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
OM953_18180	COG1956	GAF domain-containing protein
OM953_18190	COG2819	hydrolase of the alpha beta superfamily
OM953_18200	COG0546	phosphoglycolate phosphatase activity
OM953_18205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OM953_18210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OM953_18225	COG0339	signal peptide processing
OM953_18275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OM953_18280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OM953_18285	COG1136	(ABC) transporter
OM953_18290	COG0577	efflux transmembrane transporter activity
OM953_18295	COG0577	efflux transmembrane transporter activity
OM953_18295	COG1136	(ABC) transporter
OM953_18310	COG4191	Histidine kinase
OM953_18315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
OM953_18330	COG0355	proton-transporting ATP synthase activity, rotational mechanism
OM953_18335	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OM953_18340	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
OM953_18345	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OM953_18350	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OM953_18355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
OM953_18365	COG0356	it plays a direct role in the translocation of protons across the membrane
OM953_18385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OM953_18395	COG0508	dehydrogenase complex catalyzes the overall conversion of
OM953_18430	COG2011	ABC-type metal ion transport system permease component
OM953_18435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OM953_18440	COG0697	spore germination
OM953_18445	COG1666	GTP binding
OM953_18455	COG5002	protein histidine kinase activity
OM953_18455	COG2198	Histidine kinase
OM953_18455	COG0784	Response regulator, receiver
OM953_18475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OM953_18480	COG1187	pseudouridine synthase activity
OM953_18485	COG2813	Specifically methylates the guanine in position
OM953_18505	COG2205	protein histidine kinase activity
OM953_18505	COG2202	Pas domain
OM953_18525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OM953_18530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OM953_18585	COG0842	Transport permease protein
OM953_18595	COG0025	NhaP-type Na H and K H
OM953_18600	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
OM953_18605	COG1573	uracil-dna glycosylase
OM953_18615	COG3384	dioxygenase
OM953_18625	COG0583	DNA-binding transcription factor activity
OM953_18635	COG0667	Aldo Keto reductase
OM953_18645	COG3590	peptidase
OM953_18660	COG0531	amino acid
OM953_18675	COG2972	Histidine kinase
OM953_18690	COG3685	Protein conserved in bacteria
OM953_18695	COG3546	catalase activity
OM953_18730	COG2204	response regulator
OM953_18740	COG1271	oxidase subunit
OM953_18745	COG1294	oxidase, subunit
OM953_18760	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_18765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OM953_18785	COG1132	(ABC) transporter
OM953_18800	COG1063	alcohol dehydrogenase
OM953_18880	COG0251	oxidation-reduction process
OM953_18895	COG0840	transmembrane signaling receptor activity
OM953_18910	COG0583	DNA-binding transcription factor activity
OM953_18915	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OM953_18945	COG0659	secondary active sulfate transmembrane transporter activity
OM953_18955	COG0024	Methionine aminopeptidase
OM953_18965	COG1487	ribonuclease activity
OM953_18975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OM953_18975	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
OM953_19045	COG4974	Belongs to the 'phage' integrase family
OM953_19110	COG1196	nuclear chromosome segregation
OM953_19135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OM953_19140	COG1490	D-aminoacyl-tRNA deacylase activity
OM953_19145	COG1560	Kdo2-lipid A biosynthetic process
OM953_19195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OM953_19195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OM953_19200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
OM953_19205	COG0242	peptide deformylase activity
OM953_19210	COG1652	LysM domain
OM953_19215	COG0758	DNA mediated transformation
OM953_19235	COG1754	DNA topoisomerase type I activity
OM953_19235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OM953_19240	COG0009	L-threonylcarbamoyladenylate synthase
OM953_19255	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_19265	COG0616	signal peptide processing
OM953_19270	COG0534	Mate efflux family protein
OM953_19290	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OM953_19295	COG0625	glutathione transferase activity
OM953_19310	COG1252	NADH dehydrogenase
OM953_19315	COG2860	membrane
OM953_19320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OM953_19325	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
OM953_19330	COG2201	protein-glutamate methylesterase activity
OM953_19335	COG2177	Part of the ABC transporter FtsEX involved in
OM953_19340	COG2884	Cell division ATP-binding protein ftsE
OM953_19345	COG0513	Belongs to the DEAD box helicase family
OM953_19350	COG3118	belongs to the thioredoxin family
OM953_19355	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
OM953_19360	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
OM953_19365	COG0583	DNA-binding transcription factor activity
OM953_19385	COG1652	LysM domain
OM953_19390	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
OM953_19390	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
OM953_19395	COG1473	amidohydrolase
OM953_19400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OM953_19405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OM953_19425	COG5383	Protein conserved in bacteria
OM953_19465	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
OM953_19470	COG3023	N-Acetylmuramoyl-L-alanine amidase
OM953_19480	COG4948	Mandelate Racemase Muconate Lactonizing
OM953_19490	COG0531	amino acid
OM953_19505	COG4682	membrane
OM953_19510	COG2133	pyrroloquinoline quinone binding
OM953_19520	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OM953_19525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
OM953_19535	COG1610	YqeY-like protein
OM953_19540	COG1295	ribonuclease BN
OM953_19545	COG0358	DNA primase activity
OM953_19560	COG0109	protoheme IX farnesyltransferase activity
OM953_19590	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
OM953_19605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OM953_19645	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OM953_19650	COG0739	heme binding
OM953_19655	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
OM953_19665	COG2223	nitrite transmembrane transporter activity
OM953_19670	COG0708	Exodeoxyribonuclease III
OM953_19675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
OM953_19685	COG1192	Involved in chromosome partitioning
OM953_19690	COG1475	DNA binding
OM953_19705	COG0463	Glycosyl transferase, family 2
OM953_19725	COG0756	dUTP diphosphatase activity
OM953_19730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OM953_19735	COG2003	Belongs to the UPF0758 family
OM953_19740	COG0018	arginyl-trna synthetase
OM953_19755	COG4221	oxidoreductase activity
OM953_19760	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
OM953_19760	COG2755	lipolytic protein G-D-S-L family
OM953_19770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OM953_19770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OM953_19775	COG1166	arginine decarboxylase activity
OM953_19780	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
OM953_19805	COG3291	Pkd domain containing protein
OM953_19805	COG3525	Glycosyl hydrolase, family 20, catalytic domain
OM953_19820	COG0606	chelatase, subunit chli
OM953_19835	COG4943	cyclic-guanylate-specific phosphodiesterase activity
OM953_19860	COG1690	Belongs to the RtcB family
OM953_19895	COG1090	epimerase
OM953_19905	COG0642	Histidine kinase
OM953_19925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OM953_19955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OM953_19970	COG0753	catalase activity
OM953_19985	COG2197	response regulator
OM953_19990	COG4585	Histidine kinase
OM953_19995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OM953_20000	COG1136	(ABC) transporter
OM953_20025	COG0697	spore germination
OM953_20045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OM953_20050	COG0180	Tryptophanyl-tRNA synthetase
OM953_20055	COG3237	CsbD-like
OM953_20095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
OM953_20110	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
OM953_20155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OM953_20180	COG1199	ATP-dependent helicase activity
OM953_20195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OM953_20270	COG0625	glutathione transferase activity
OM953_20305	COG4555	ABC transporter
OM953_20315	COG1476	TRANSCRIPTIONal
OM953_20335	COG1230	cation diffusion facilitator family transporter
OM953_20345	COG4774	siderophore transport
OM953_20360	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OM953_20365	COG1131	(ABC) transporter
OM953_20370	COG0842	Transport permease protein
OM953_20375	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OM953_20395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OM953_20405	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OM953_20410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OM953_20420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OM953_20420	COG1042	CoA-binding domain protein
OM953_20420	COG0045	succinate-CoA ligase (ADP-forming) activity
OM953_20425	COG2239	Acts as a magnesium transporter
OM953_20440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OM953_20445	COG3387	PFAM Glycoside hydrolase 15-related
OM953_20460	COG3100	YcgL domain-containing protein
OM953_20465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OM953_20475	COG0463	Glycosyl transferase, family 2
OM953_20495	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_20550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OM953_20575	COG1506	peptidase
OM953_20575	COG0823	Involved in the tonB-independent uptake of proteins
OM953_20575	COG4946	Tricorn protease homolog
OM953_20590	COG0408	coproporphyrinogen oxidase activity
OM953_20625	COG0515	serine threonine protein kinase
OM953_20630	COG0631	protein serine/threonine phosphatase activity
OM953_20805	COG0210	DNA helicase
OM953_20815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OM953_20820	COG0583	DNA-binding transcription factor activity
OM953_20825	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OM953_20835	COG2159	amidohydrolase
OM953_20855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OM953_20875	COG0357	Ribosomal RNA small subunit methyltransferase G
OM953_20880	COG3540	Alkaline phosphatase
OM953_20890	COG2091	lysine biosynthetic process via aminoadipic acid
OM953_20905	COG0708	Exodeoxyribonuclease III
OM953_20910	COG1940	carbohydrate kinase activity
OM953_20910	COG1846	Transcriptional regulator
OM953_20920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OM953_20930	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OM953_20935	COG3162	membrane
OM953_20945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OM953_20970	COG3507	Belongs to the glycosyl hydrolase 43 family
OM953_20990	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_20995	COG0179	Fumarylacetoacetate (FAA) hydrolase
OM953_21000	COG4948	Mandelate Racemase Muconate Lactonizing
OM953_21005	COG3254	rhamnose metabolic process
OM953_21010	COG0738	Major facilitator superfamily
OM953_21015	COG1414	Transcriptional regulator
OM953_21020	COG1971	Probably functions as a manganese efflux pump
OM953_21025	COG2205	protein histidine kinase activity
OM953_21035	COG3459	Glycosyltransferase 36 associated
OM953_21040	COG2211	Major facilitator Superfamily
OM953_21045	COG3265	gluconokinase activity
OM953_21050	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OM953_21070	COG2911	Protein conserved in bacteria
OM953_21075	COG0729	surface antigen
OM953_21115	COG0752	glycyl-tRNA synthetase alpha subunit
OM953_21120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OM953_21135	COG0519	Catalyzes the synthesis of GMP from XMP
OM953_21135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OM953_21145	COG0805	protein transport
OM953_21150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OM953_21155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OM953_21165	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OM953_21180	COG2974	May be involved in recombination
OM953_21185	COG0037	tRNA processing
OM953_21190	COG2115	Belongs to the xylose isomerase family
OM953_21200	COG3661	Belongs to the glycosyl hydrolase 67 family
OM953_21210	COG4948	Mandelate Racemase Muconate Lactonizing
OM953_21220	COG1472	Belongs to the glycosyl hydrolase 3 family
OM953_21225	COG0246	Mannitol dehydrogenase
OM953_21270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OM953_21295	COG3386	PFAM SMP-30 Gluconolaconase
OM953_21305	COG3250	beta-galactosidase activity
OM953_21310	COG1904	glucuronate isomerase
OM953_21330	COG3693	PFAM glycoside hydrolase, family 10
OM953_21345	COG2211	Major facilitator Superfamily
OM953_21395	COG0604	alcohol dehydrogenase
OM953_21395	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_21395	COG3321	synthase
OM953_21400	COG2937	Belongs to the GPAT DAPAT family
OM953_21430	COG0284	orotidine-5'-phosphate decarboxylase activity
OM953_21435	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
OM953_21440	COG3132	Protein of unknown function, DUF480
OM953_21455	COG0210	DNA helicase
OM953_21460	COG1435	thymidine kinase activity
OM953_21470	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
OM953_21480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OM953_21510	COG3135	benzoate transporter
OM953_21530	COG0676	glucose-6-phosphate 1-epimerase activity
OM953_21540	COG3012	SEC-C Motif Domain Protein
OM953_21545	COG0730	response to heat
OM953_21565	COG0302	gtp cyclohydrolase
OM953_21580	COG1566	PFAM secretion protein HlyD family protein
OM953_21590	COG1289	transmembrane transporter activity
OM953_21595	COG0477	Major facilitator Superfamily
OM953_21605	COG0583	DNA-binding transcription factor activity
OM953_21610	COG4221	oxidoreductase activity
OM953_21620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OM953_21685	COG0564	pseudouridine synthase activity
OM953_21725	COG1028	Short-chain dehydrogenase reductase Sdr
OM953_21760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OM953_21770	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
OM953_21805	COG1127	ABC transporter
OM953_21810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OM953_21815	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OM953_21830	COG2853	Lipoprotein
OM953_21840	COG0386	Belongs to the glutathione peroxidase family
OM953_21860	COG0625	glutathione transferase activity
OM953_21870	COG0531	amino acid
OM953_21875	COG3537	Alpha-1,2-mannosidase
OM953_21885	COG3706	GGDEF domain
OM953_21890	COG3835	regulator
OM953_21920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OM953_21925	COG0861	Integral membrane protein TerC family
OM953_21935	COG0584	glycerophosphoryl diester phosphodiesterase
OM953_21950	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
OM953_21965	COG0706	membrane insertase activity
OM953_21970	COG0594	ribonuclease P activity
OM953_22030	COG3328	transposase activity
OM953_22055	COG4962	Type ii secretion system protein e
OM953_22070	COG3451	type IV secretory pathway VirB4
OM953_22085	COG3846	protein secretion by the type IV secretion system
OM953_22120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OM953_22135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OM953_22150	COG1487	ribonuclease activity
OM953_22155	COG4691	Plasmid stability protein
OM953_22160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs