locus-tag	class	description
AC614_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AC614_00020	COG0187	DNA topoisomerase II activity
AC614_00030	COG0501	Belongs to the peptidase M48B family
AC614_00070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AC614_00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC614_00125	COG0793	Belongs to the peptidase S41A family
AC614_00130	COG4942	peptidase
AC614_00140	COG2234	aminopeptidase activity
AC614_00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC614_00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC614_00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC614_00165	COG1064	alcohol dehydrogenase
AC614_00170	COG0493	'glutamate synthase
AC614_00175	COG0069	glutamate synthase activity
AC614_00175	COG0067	glutamate synthase
AC614_00175	COG0070	glutamate synthase
AC614_00255	COG1205	dead DEAH box helicase
AC614_00255	COG1111	helicase
AC614_00260	COG1272	protein, Hemolysin III
AC614_00275	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_00280	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_00300	COG2249	NAD(P)H dehydrogenase (quinone) activity
AC614_00305	COG2963	transposase activity
AC614_00315	COG3039	Transposase
AC614_00320	COG3039	Transposase
AC614_00350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AC614_00365	COG0517	IMP dehydrogenase activity
AC614_00365	COG1125	glycine betaine transport
AC614_00380	COG1119	ATPase activity
AC614_00390	COG1752	Esterase of the alpha-beta hydrolase superfamily
AC614_00400	COG1522	sequence-specific DNA binding
AC614_00405	COG3186	Phenylalanine-4-hydroxylase
AC614_00415	COG2755	lipolytic protein G-D-S-L family
AC614_00425	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_00430	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AC614_00435	COG1609	Transcriptional regulator
AC614_00440	COG3507	Belongs to the glycosyl hydrolase 43 family
AC614_00455	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC614_00465	COG0657	acetylesterase activity
AC614_00465	COG2755	lipolytic protein G-D-S-L family
AC614_00485	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC614_00490	COG0366	Alpha amylase catalytic
AC614_00495	COG0366	Alpha amylase catalytic
AC614_00510	COG3039	Transposase
AC614_00535	COG3328	transposase activity
AC614_00540	COG3039	Transposase
AC614_00550	COG3328	transposase activity
AC614_00575	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AC614_00580	COG3710	Transcriptional regulator
AC614_00600	COG2197	response regulator
AC614_00605	COG4585	Histidine kinase
AC614_00615	COG1304	FMN binding
AC614_00640	COG1012	belongs to the aldehyde dehydrogenase family
AC614_00650	COG3039	Transposase
AC614_00660	COG4772	TonB-dependent receptor
AC614_00670	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AC614_00700	COG0714	Associated with various cellular activities
AC614_00740	COG0477	Major facilitator Superfamily
AC614_00745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC614_00765	COG3039	Transposase
AC614_00800	COG3237	CsbD-like
AC614_00810	COG3039	Transposase
AC614_00825	COG0489	protein tyrosine kinase activity
AC614_00830	COG2062	phosphohistidine phosphatase, SixA
AC614_00840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC614_00885	COG1968	undecaprenyl-diphosphatase activity
AC614_00890	COG0174	glutamine synthetase
AC614_00895	COG0347	Belongs to the P(II) protein family
AC614_00900	COG0004	ammonium transporteR
AC614_00905	COG3852	Histidine kinase
AC614_00910	COG2204	response regulator
AC614_00915	COG2032	superoxide dismutase activity
AC614_00920	COG2032	superoxide dismutase activity
AC614_00930	COG3039	Transposase
AC614_00940	COG0183	Belongs to the thiolase family
AC614_00975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AC614_00980	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AC614_00985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AC614_00995	COG0028	Belongs to the TPP enzyme family
AC614_01000	COG2205	protein histidine kinase activity
AC614_01025	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AC614_01040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC614_01050	COG0596	Alpha beta hydrolase
AC614_01060	COG0318	PFAM AMP-dependent synthetase and ligase
AC614_01065	COG0745	RESPONSE REGULATOR receiver
AC614_01075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC614_01100	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AC614_01110	COG0564	pseudouridine synthase activity
AC614_01130	COG1446	asparaginase
AC614_01135	COG0339	signal peptide processing
AC614_01165	COG0475	glutathione-regulated potassium exporter activity
AC614_01170	COG0583	DNA-binding transcription factor activity
AC614_01175	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AC614_01180	COG2224	Isocitrate lyase
AC614_01185	COG3706	GGDEF domain
AC614_01200	COG3039	Transposase
AC614_01235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AC614_01240	COG1960	acyl-CoA dehydrogenase activity
AC614_01310	COG0697	spore germination
AC614_01320	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AC614_01325	COG1846	Transcriptional regulator
AC614_01330	COG1764	response to oxidative stress
AC614_01360	COG2130	NADP-dependent
AC614_01375	COG1187	pseudouridine synthase activity
AC614_01390	COG1643	Atp-dependent helicase
AC614_01395	COG4807	Protein conserved in bacteria
AC614_01400	COG2351	hydroxyisourate hydrolase activity
AC614_01405	COG2072	flavoprotein involved in K transport
AC614_01425	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AC614_01435	COG0583	DNA-binding transcription factor activity
AC614_01470	COG2252	PERMEase
AC614_01510	COG0583	DNA-binding transcription factor activity
AC614_01515	COG2814	Major facilitator Superfamily
AC614_01525	COG2267	carboxylic ester hydrolase activity
AC614_01530	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AC614_01535	COG1902	pentaerythritol trinitrate reductase activity
AC614_01555	COG0745	RESPONSE REGULATOR receiver
AC614_01560	COG2205	protein histidine kinase activity
AC614_01565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC614_01585	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AC614_01590	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AC614_01595	COG0583	DNA-binding transcription factor activity
AC614_01630	COG0702	epimerase
AC614_01635	COG1733	regulation of RNA biosynthetic process
AC614_01655	COG3039	Transposase
AC614_01680	COG3328	transposase activity
AC614_01705	COG3039	Transposase
AC614_01715	COG0129	dihydroxy-acid dehydratase activity
AC614_01735	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AC614_01790	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AC614_01795	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AC614_01820	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AC614_01825	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AC614_01835	COG3485	protocatechuate 3,4-dioxygenase
AC614_01840	COG3485	protocatechuate 3,4-dioxygenase
AC614_01850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC614_01855	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AC614_01865	COG1414	Transcriptional regulator
AC614_01885	COG0445	tRNA wobble uridine modification
AC614_01925	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_01930	COG2267	carboxylic ester hydrolase activity
AC614_01940	COG0156	8-amino-7-oxononanoate synthase activity
AC614_01945	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AC614_01950	COG1040	competence protein
AC614_01955	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AC614_01980	COG3039	Transposase
AC614_02045	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AC614_02115	COG1511	domain protein
AC614_02115	COG3264	Mechanosensitive ion channel
AC614_02120	COG1368	sulfuric ester hydrolase activity
AC614_02125	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AC614_02135	COG2354	Protein conserved in bacteria
AC614_02140	COG0745	RESPONSE REGULATOR receiver
AC614_02140	COG3706	GGDEF domain
AC614_02145	COG0297	glycogen (starch) synthase activity
AC614_02150	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC614_02155	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC614_02180	COG0702	epimerase
AC614_02185	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_02220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC614_02225	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_02235	COG0513	Belongs to the DEAD box helicase family
AC614_02240	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC614_02255	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AC614_02265	COG3483	tryptophan 2,3-dioxygenase activity
AC614_02270	COG3104	oligopeptide transport
AC614_02305	COG1320	monovalent cation:proton antiporter activity
AC614_02310	COG2212	antiporter activity
AC614_02320	COG0651	ATP synthesis coupled electron transport
AC614_02325	COG1006	Multisubunit Na H antiporter MnhC subunit
AC614_02330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC614_02330	COG2111	Na H antiporter
AC614_02355	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AC614_02360	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AC614_02375	COG0456	acetyltransferase
AC614_02380	COG1597	lipid kinase activity
AC614_02400	COG3039	Transposase
AC614_02405	COG3039	Transposase
AC614_02410	COG3039	Transposase
AC614_02420	COG3039	Transposase
AC614_02440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AC614_02445	COG0134	indole-3-glycerol-phosphate synthase activity
AC614_02455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC614_02460	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AC614_02470	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AC614_02475	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AC614_02480	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AC614_02495	COG1051	belongs to the nudix hydrolase family
AC614_02535	COG0316	Belongs to the HesB IscA family
AC614_02550	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AC614_02565	COG2814	Major facilitator Superfamily
AC614_02575	COG2814	Major facilitator Superfamily
AC614_02580	COG1289	transmembrane transporter activity
AC614_02590	COG0151	Belongs to the GarS family
AC614_02600	COG0138	bifunctional purine biosynthesis protein purh
AC614_02605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AC614_02615	COG0671	phosphoesterase, PA-phosphatase related
AC614_02615	COG2453	phosphatase
AC614_02640	COG4589	Belongs to the CDS family
AC614_02645	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AC614_02670	COG2264	protein methyltransferase activity
AC614_02685	COG0439	Biotin carboxylase
AC614_02695	COG0511	ligase activity, forming carbon-carbon bonds
AC614_02700	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AC614_02710	COG1324	tolerance protein
AC614_02715	COG2356	endonuclease I
AC614_02720	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AC614_02725	COG0459	protein refolding
AC614_02740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AC614_02755	COG3386	PFAM SMP-30 Gluconolaconase
AC614_02765	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AC614_02770	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AC614_02800	COG0778	Nitroreductase
AC614_02805	COG2353	YceI-like domain
AC614_02835	COG3052	prosthetic group binding
AC614_02855	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AC614_02860	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AC614_02870	COG1802	Transcriptional regulator
AC614_02920	COG3328	transposase activity
AC614_02935	COG3039	Transposase
AC614_02945	COG4221	oxidoreductase activity
AC614_02960	COG4221	oxidoreductase activity
AC614_02970	COG0435	Glutathione S-transferase
AC614_03005	COG1506	peptidase
AC614_03005	COG0823	Involved in the tonB-independent uptake of proteins
AC614_03015	COG3706	GGDEF domain
AC614_03035	COG0697	spore germination
AC614_03040	COG4305	rare lipoprotein A
AC614_03050	COG5297	Belongs to the glycosyl hydrolase family 6
AC614_03065	COG1113	amino acid transport
AC614_03075	COG0598	Magnesium transport protein CorA
AC614_03085	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AC614_03120	COG0840	transmembrane signaling receptor activity
AC614_03125	COG5297	Belongs to the glycosyl hydrolase family 6
AC614_03125	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC614_03130	COG0659	secondary active sulfate transmembrane transporter activity
AC614_03145	COG2943	transferase activity, transferring hexosyl groups
AC614_03155	COG3275	phosphorelay sensor kinase activity
AC614_03165	COG0181	hydroxymethylbilane synthase activity
AC614_03190	COG1505	serine-type exopeptidase activity
AC614_03205	COG2832	Protein of unknown function (DUF454)
AC614_03215	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AC614_03225	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AC614_03230	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AC614_03235	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AC614_03260	COG2226	methyltransferase
AC614_03265	COG3300	MHYT domain
AC614_03265	COG5001	Diguanylate cyclase
AC614_03270	COG0308	aminopeptidase N
AC614_03325	COG1077	Cell shape determining protein MreB Mrl
AC614_03330	COG1792	Involved in formation and maintenance of cell shape
AC614_03345	COG0772	Belongs to the SEDS family
AC614_03355	COG2951	lytic endotransglycosylase activity
AC614_03360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AC614_03365	COG1686	Belongs to the peptidase S11 family
AC614_03375	COG2921	Belongs to the UPF0250 family
AC614_03380	COG0321	lipoyl(octanoyl) transferase activity
AC614_03385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AC614_03410	COG1056	cytidyltransferase-related domain
AC614_03410	COG1051	belongs to the nudix hydrolase family
AC614_03445	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AC614_03450	COG0673	inositol 2-dehydrogenase activity
AC614_03455	COG2823	Periplasmic or secreted lipoprotein
AC614_03460	COG4251	negative regulation of phosphorylation
AC614_03465	COG0784	Response regulator, receiver
AC614_03470	COG4191	Histidine kinase
AC614_03475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AC614_03530	COG1459	type II secretion system
AC614_03535	COG2165	general secretion pathway protein
AC614_03550	COG4795	General secretion pathway protein
AC614_03580	COG3250	beta-galactosidase activity
AC614_03605	COG1609	Transcriptional regulator
AC614_03610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AC614_03615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AC614_03630	COG0617	tRNA 3'-terminal CCA addition
AC614_03635	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AC614_03640	COG1012	belongs to the aldehyde dehydrogenase family
AC614_03645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC614_03655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC614_03670	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AC614_03695	COG2205	protein histidine kinase activity
AC614_03700	COG0745	RESPONSE REGULATOR receiver
AC614_03725	COG3791	Glutathione-dependent formaldehyde-activating
AC614_03740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC614_03760	COG0488	(ABC) transporter
AC614_03770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AC614_03775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AC614_03785	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AC614_03785	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AC614_03805	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AC614_03810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC614_03815	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AC614_03835	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AC614_03840	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AC614_03845	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AC614_03850	COG2205	protein histidine kinase activity
AC614_03855	COG0745	RESPONSE REGULATOR receiver
AC614_03860	COG0277	FAD linked oxidase domain protein
AC614_03865	COG1988	membrane-bound metal-dependent
AC614_03870	COG0792	nuclease activity
AC614_03890	COG2001	Belongs to the MraZ family
AC614_03895	COG0275	rRNA processing
AC614_03900	COG3116	cell division
AC614_03910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AC614_03915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AC614_03920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AC614_03930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AC614_03935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AC614_03940	COG1181	Belongs to the D-alanine--D-alanine ligase family
AC614_03945	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AC614_03960	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AC614_03970	COG0739	heme binding
AC614_03975	COG0653	protein targeting
AC614_03980	COG0494	nUDIX hydrolase
AC614_03990	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AC614_04000	COG0604	alcohol dehydrogenase
AC614_04000	COG3321	synthase
AC614_04000	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_04020	COG0366	Alpha amylase catalytic
AC614_04055	COG2226	methyltransferase
AC614_04060	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AC614_04070	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AC614_04110	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AC614_04120	COG4106	trans-aconitate 2-methyltransferase activity
AC614_04125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AC614_04135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC614_04140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AC614_04150	COG0667	Aldo Keto reductase
AC614_04160	COG4771	TonB-dependent receptor
AC614_04180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC614_04185	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AC614_04195	COG2175	clavaminate synthase activity
AC614_04205	COG4181	ATPase activity
AC614_04220	COG0642	Histidine kinase
AC614_04230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AC614_04250	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AC614_04255	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AC614_04270	COG3829	transcription factor binding
AC614_04280	COG1116	anion transmembrane transporter activity
AC614_04285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC614_04295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC614_04300	COG0431	NADPH-dependent FMN reductase
AC614_04320	COG0747	negative chemotaxis
AC614_04340	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AC614_04345	COG2967	ApaG domain
AC614_04350	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AC614_04355	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AC614_04360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC614_04365	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AC614_04380	COG0123	including yeast histone deacetylase and acetoin utilization protein
AC614_04385	COG2096	Adenosyltransferase
AC614_04395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC614_04400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC614_04430	COG3384	dioxygenase
AC614_04435	COG0583	DNA-binding transcription factor activity
AC614_04450	COG1024	Enoyl-CoA hydratase
AC614_04480	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AC614_04505	COG0697	spore germination
AC614_04515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC614_04530	COG3706	GGDEF domain
AC614_04530	COG0745	RESPONSE REGULATOR receiver
AC614_04540	COG2197	response regulator
AC614_04550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AC614_04560	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AC614_04565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC614_04570	COG0583	DNA-binding transcription factor activity
AC614_04575	COG3634	alkyl hydroperoxide reductase activity
AC614_04585	COG2890	protein-(glutamine-N5) methyltransferase activity
AC614_04605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AC614_04605	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AC614_04625	COG3039	Transposase
AC614_04640	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AC614_04660	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AC614_04665	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AC614_04680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AC614_04685	COG1404	Belongs to the peptidase S8 family
AC614_04690	COG1404	Belongs to the peptidase S8 family
AC614_04695	COG1404	Belongs to the peptidase S8 family
AC614_04700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AC614_04725	COG1295	ribonuclease BN
AC614_04730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC614_04735	COG1254	Belongs to the acylphosphatase family
AC614_04750	COG0521	Mo-molybdopterin cofactor biosynthetic process
AC614_04760	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AC614_04765	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AC614_04775	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AC614_04780	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AC614_04790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AC614_04795	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AC614_04800	COG0193	aminoacyl-tRNA hydrolase activity
AC614_04805	COG0012	GTP binding
AC614_04825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AC614_04835	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AC614_04840	COG0250	Participates in transcription elongation, termination and antitermination
AC614_04845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AC614_04850	COG0081	regulation of translation
AC614_04855	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AC614_04860	COG0222	ribosome binding
AC614_04865	COG0085	RNA polymerase activity
AC614_04870	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AC614_04875	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AC614_04880	COG0049	tRNA binding
AC614_04885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AC614_04890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AC614_04895	COG0051	transcription antitermination factor activity, RNA binding
AC614_04900	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AC614_04905	COG0088	Forms part of the polypeptide exit tunnel
AC614_04910	COG0089	rRNA binding
AC614_04915	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AC614_04920	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AC614_04925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AC614_04930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AC614_04935	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AC614_04940	COG0255	Belongs to the universal ribosomal protein uL29 family
AC614_04945	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AC614_04950	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AC614_04955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AC614_04960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AC614_04965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AC614_04970	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AC614_04975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AC614_04980	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AC614_04985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AC614_04990	COG1841	ribosomal large subunit assembly
AC614_04995	COG0200	Binds to the 23S rRNA
AC614_05000	COG0201	protein transport
AC614_05005	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AC614_05010	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AC614_05015	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AC614_05020	COG0202	RNA polymerase activity
AC614_05025	COG0203	ribosomal protein L17
AC614_05030	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AC614_05045	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AC614_05055	COG0154	amidase activity
AC614_05070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AC614_05075	COG0039	L-malate dehydrogenase activity
AC614_05080	COG0625	glutathione transferase activity
AC614_05095	COG0446	pyridine nucleotide-disulphide oxidoreductase
AC614_05095	COG1902	pentaerythritol trinitrate reductase activity
AC614_05100	COG0604	alcohol dehydrogenase
AC614_05125	COG0156	8-amino-7-oxononanoate synthase activity
AC614_05135	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AC614_05140	COG4208	sulfate ABC transporter
AC614_05145	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AC614_05155	COG1063	alcohol dehydrogenase
AC614_05175	COG0406	alpha-ribazole phosphatase activity
AC614_05180	COG0285	dihydrofolate synthase activity
AC614_05200	COG2833	Protein of unknown function (DUF455)
AC614_05215	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC614_05220	COG0671	phosphoesterase, PA-phosphatase related
AC614_05225	COG0438	transferase activity, transferring glycosyl groups
AC614_05235	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AC614_05250	COG4783	chaperone-mediated protein folding
AC614_05265	COG0473	3-isopropylmalate dehydrogenase activity
AC614_05305	COG0544	peptidyl-prolyl cis-trans isomerase activity
AC614_05310	COG0740	serine-type endopeptidase activity
AC614_05315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AC614_05345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC614_05355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC614_05365	COG0328	RNA-DNA hybrid ribonuclease activity
AC614_05370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AC614_05375	COG0631	protein serine/threonine phosphatase activity
AC614_05390	COG0859	PFAM glycosyl transferase family 9
AC614_05395	COG3642	lipopolysaccharide core region biosynthetic process
AC614_05400	COG1234	tRNA 3'-trailer cleavage
AC614_05405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AC614_05415	COG0315	cyclic pyranopterin monophosphate synthase activity
AC614_05420	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AC614_05425	COG0314	molybdopterin synthase activity
AC614_05460	COG3328	transposase activity
AC614_05465	COG3039	Transposase
AC614_05475	COG3328	transposase activity
AC614_05495	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AC614_05500	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AC614_05505	COG0537	adenosine 5'-monophosphoramidase activity
AC614_05525	COG0714	Associated with various cellular activities
AC614_05545	COG0424	maF-like protein
AC614_05550	COG1399	metal-binding, possibly nucleic acid-binding protein
AC614_05560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC614_05570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AC614_05575	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_05580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AC614_05590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AC614_05595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AC614_05620	COG3829	transcription factor binding
AC614_05655	COG2373	Large extracellular alpha-helical protein
AC614_05670	COG4953	penicillin-binding protein 1C
AC614_05680	COG0678	peroxiredoxin activity
AC614_05700	COG0330	HflC and HflK could
AC614_05705	COG0330	HflC and HflK could
AC614_05715	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AC614_05730	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_05735	COG1309	transcriptional regulator
AC614_05745	COG3328	transposase activity
AC614_05750	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AC614_05755	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
AC614_05765	COG3039	Transposase
AC614_05770	COG0732	type I restriction modification DNA specificity domain
AC614_05785	COG3039	Transposase
AC614_05790	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AC614_05815	COG0406	alpha-ribazole phosphatase activity
AC614_05815	COG0328	RNA-DNA hybrid ribonuclease activity
AC614_05820	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AC614_05830	COG3387	PFAM Glycoside hydrolase 15-related
AC614_05835	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_05840	COG3328	transposase activity
AC614_05845	COG3537	Alpha-1,2-mannosidase
AC614_05850	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_05865	COG0492	ferredoxin-NADP+ reductase activity
AC614_05895	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC614_05900	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AC614_05905	COG2080	2 iron, 2 sulfur cluster binding
AC614_05940	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC614_05960	COG0587	DNA-directed DNA polymerase activity
AC614_05975	COG1297	OPT oligopeptide transporter protein
AC614_05990	COG1506	peptidase
AC614_05990	COG0823	Involved in the tonB-independent uptake of proteins
AC614_06005	COG2207	Transcriptional regulator
AC614_06005	COG1917	Cupin 2, conserved barrel domain protein
AC614_06025	COG0753	catalase activity
AC614_06030	COG0656	L-ascorbic acid biosynthetic process
AC614_06040	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC614_06040	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC614_06045	COG2814	Major facilitator Superfamily
AC614_06060	COG2194	sulfuric ester hydrolase activity
AC614_06075	COG0745	RESPONSE REGULATOR receiver
AC614_06080	COG0642	Histidine kinase
AC614_06090	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AC614_06095	COG2894	cell division
AC614_06100	COG0850	regulation of cytokinetic process
AC614_06110	COG4585	Histidine kinase
AC614_06115	COG2197	response regulator
AC614_06130	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AC614_06155	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AC614_06165	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AC614_06185	COG1946	Acyl-CoA thioesterase
AC614_06200	COG0824	Thioesterase
AC614_06205	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AC614_06210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AC614_06215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AC614_06220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AC614_06225	COG0268	Binds directly to 16S ribosomal RNA
AC614_06235	COG0196	riboflavin kinase activity
AC614_06240	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AC614_06245	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AC614_06250	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AC614_06280	COG3328	transposase activity
AC614_06300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AC614_06305	COG1845	cytochrome c oxidase, subunit III
AC614_06310	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AC614_06330	COG3328	transposase activity
AC614_06335	COG3328	transposase activity
AC614_06340	COG3152	Membrane
AC614_06350	COG2207	Transcriptional regulator
AC614_06355	COG0326	Molecular chaperone. Has ATPase activity
AC614_06365	COG1366	Belongs to the anti-sigma-factor antagonist family
AC614_06370	COG1366	Belongs to the anti-sigma-factor antagonist family
AC614_06375	COG2172	sigma factor antagonist activity
AC614_06400	COG4771	TonB-dependent receptor
AC614_06410	COG5507	3-demethylubiquinone-9 3-methyltransferase
AC614_06420	COG2205	protein histidine kinase activity
AC614_06430	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AC614_06435	COG3437	response regulator, receiver
AC614_06435	COG2205	protein histidine kinase activity
AC614_06435	COG4999	Histidine kinase
AC614_06435	COG3850	Histidine kinase
AC614_06440	COG0784	Response regulator, receiver
AC614_06440	COG4191	Histidine kinase
AC614_06455	COG3328	transposase activity
AC614_06460	COG3039	Transposase
AC614_06470	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AC614_06480	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AC614_06505	COG0534	Mate efflux family protein
AC614_06510	COG0335	large ribosomal subunit rRNA binding
AC614_06515	COG0336	Belongs to the RNA methyltransferase TrmD family
AC614_06520	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AC614_06525	COG0228	four-way junction DNA binding
AC614_06545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AC614_06550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AC614_06575	COG3328	transposase activity
AC614_06580	COG2963	transposase activity
AC614_06595	COG3250	beta-galactosidase activity
AC614_06600	COG3867	Arabinogalactan endo-beta-1,4-galactanase
AC614_06620	COG1960	acyl-CoA dehydrogenase activity
AC614_06625	COG1024	Enoyl-CoA hydratase
AC614_06660	COG0237	dephospho-CoA kinase activity
AC614_06665	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AC614_06670	COG1459	type II secretion system
AC614_06710	COG0045	succinate-CoA ligase (ADP-forming) activity
AC614_06715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AC614_06720	COG3328	transposase activity
AC614_06730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC614_06730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AC614_06740	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC614_06745	COG0564	pseudouridine synthase activity
AC614_06760	COG3011	Protein conserved in bacteria
AC614_06765	COG0840	transmembrane signaling receptor activity
AC614_06780	COG3387	PFAM Glycoside hydrolase 15-related
AC614_06785	COG1877	trehalose-phosphatase activity
AC614_06825	COG2827	Endonuclease containing a URI domain
AC614_06830	COG4771	TonB-dependent receptor
AC614_06840	COG0667	Aldo Keto reductase
AC614_06845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC614_06850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC614_06855	COG1116	anion transmembrane transporter activity
AC614_06860	COG0542	response to heat
AC614_06870	COG4206	TonB-dependent receptor
AC614_06895	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AC614_06905	COG1492	cobalamin metabolic process
AC614_06915	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AC614_06940	COG0019	diaminopimelate decarboxylase activity
AC614_06955	COG4264	IucA IucC family
AC614_06965	COG4772	TonB-dependent receptor
AC614_06975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AC614_06975	COG4651	solute:proton antiporter activity
AC614_07005	COG0488	(ABC) transporter
AC614_07040	COG0477	Major facilitator Superfamily
AC614_07055	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AC614_07070	COG0217	transcriptional regulatory protein
AC614_07075	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AC614_07080	COG0632	four-way junction helicase activity
AC614_07085	COG3158	transport of potassium into the cell
AC614_07090	COG2255	four-way junction helicase activity
AC614_07095	COG0824	Thioesterase
AC614_07105	COG0848	biopolymer transport protein
AC614_07115	COG0823	Involved in the tonB-independent uptake of proteins
AC614_07120	COG2885	chlorophyll binding
AC614_07130	COG0602	queuosine metabolic process
AC614_07145	COG3920	Histidine kinase
AC614_07165	COG0840	transmembrane signaling receptor activity
AC614_07210	COG0514	ATP-dependent DNA helicase (RecQ)
AC614_07215	COG0783	Belongs to the Dps family
AC614_07220	COG1643	Atp-dependent helicase
AC614_07230	COG0837	glucose binding
AC614_07245	COG0535	radical SAM domain protein
AC614_07250	COG0535	radical SAM domain protein
AC614_07255	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AC614_07260	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AC614_07265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AC614_07275	COG1215	transferase activity, transferring glycosyl groups
AC614_07280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC614_07290	COG1199	ATP-dependent helicase activity
AC614_07300	COG1397	ADP-ribosylglycohydrolase
AC614_07310	COG0189	ligase activity
AC614_07325	COG0835	chemotaxis
AC614_07330	COG0840	transmembrane signaling receptor activity
AC614_07360	COG1446	asparaginase
AC614_07365	COG3142	Participates in the control of copper homeostasis
AC614_07405	COG3537	Alpha-1,2-mannosidase
AC614_07415	COG1486	melibiose metabolic process
AC614_07425	COG0531	amino acid
AC614_07450	COG1472	Belongs to the glycosyl hydrolase 3 family
AC614_07460	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AC614_07465	COG3858	chitin binding
AC614_07465	COG1388	LysM domain
AC614_07480	COG0837	glucose binding
AC614_07485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AC614_07495	COG0494	nUDIX hydrolase
AC614_07500	COG1218	3'(2'),5'-bisphosphate nucleotidase
AC614_07505	COG3956	TIGRFAM MazG family protein
AC614_07510	COG1742	UPF0060 membrane protein
AC614_07520	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AC614_07525	COG0509	glycine decarboxylation via glycine cleavage system
AC614_07545	COG3328	transposase activity
AC614_07570	COG1960	acyl-CoA dehydrogenase activity
AC614_07575	COG2267	carboxylic ester hydrolase activity
AC614_07580	COG1309	transcriptional regulator
AC614_07585	COG3039	Transposase
AC614_07590	COG3039	Transposase
AC614_07595	COG3328	transposase activity
AC614_07600	COG4771	TonB-dependent receptor
AC614_07610	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AC614_07615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC614_07620	COG0463	Glycosyl transferase, family 2
AC614_07625	COG0516	GMP reductase activity
AC614_07625	COG0517	IMP dehydrogenase activity
AC614_07630	COG2982	Protein involved in outer membrane biogenesis
AC614_07635	COG1272	protein, Hemolysin III
AC614_07640	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AC614_07645	COG0739	heme binding
AC614_07650	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC614_07655	COG0626	cystathionine gamma-synthase activity
AC614_07660	COG0527	aspartate kinase activity
AC614_07660	COG0460	homoserine dehydrogenase
AC614_07670	COG1760	l-serine dehydratase
AC614_07690	COG2353	YceI-like domain
AC614_07695	COG0784	Response regulator, receiver
AC614_07695	COG2198	Histidine kinase
AC614_07695	COG2205	protein histidine kinase activity
AC614_07715	COG0477	Major facilitator Superfamily
AC614_07720	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AC614_07730	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AC614_07735	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AC614_07740	COG0259	pyridoxamine-phosphate oxidase activity
AC614_07750	COG1842	Phage shock protein A
AC614_07775	COG0754	glutathionylspermidine amidase activity
AC614_07780	COG2814	Major facilitator Superfamily
AC614_07840	COG0531	amino acid
AC614_07845	COG2197	response regulator
AC614_07865	COG3328	transposase activity
AC614_07870	COG1113	amino acid transport
AC614_07880	COG1271	oxidase subunit
AC614_07885	COG1294	oxidase, subunit
AC614_07895	COG2239	Acts as a magnesium transporter
AC614_07900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AC614_07905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC614_07915	COG1660	Displays ATPase and GTPase activities
AC614_07920	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AC614_07925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC614_07940	COG1137	ATPase activity
AC614_07945	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AC614_07955	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AC614_07965	COG0271	Belongs to the BolA IbaG family
AC614_07970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AC614_07990	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AC614_08000	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AC614_08010	COG0628	permease
AC614_08020	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AC614_08025	COG3178	'Phosphotransferase
AC614_08040	COG1555	photosystem II stabilization
AC614_08050	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AC614_08055	COG1477	protein flavinylation
AC614_08080	COG3128	pkhd-type hydroxylase
AC614_08085	COG4774	siderophore transport
AC614_08100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AC614_08105	COG0719	Fe-S assembly protein
AC614_08110	COG0396	ATPase activity
AC614_08115	COG0719	Fe-S assembly protein
AC614_08120	COG1959	2 iron, 2 sulfur cluster binding
AC614_08130	COG0693	protein deglycase activity
AC614_08150	COG0739	heme binding
AC614_08165	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AC614_08190	COG0519	Catalyzes the synthesis of GMP from XMP
AC614_08200	COG1678	Uncharacterized ACR, COG1678
AC614_08205	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AC614_08210	COG0540	Belongs to the ATCase OTCase family
AC614_08215	COG1764	response to oxidative stress
AC614_08225	COG0384	phenazine biosynthesis protein PhzF
AC614_08230	COG0384	phenazine biosynthesis protein PhzF
AC614_08235	COG0527	aspartate kinase activity
AC614_08250	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AC614_08260	COG0142	geranyltranstransferase activity
AC614_08265	COG0629	single-stranded DNA binding
AC614_08270	COG5001	Diguanylate cyclase
AC614_08270	COG2203	Gaf domain
AC614_08270	COG4251	negative regulation of phosphorylation
AC614_08270	COG3706	GGDEF domain
AC614_08275	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_08275	COG3321	synthase
AC614_08275	COG0604	alcohol dehydrogenase
AC614_08280	COG2080	2 iron, 2 sulfur cluster binding
AC614_08285	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AC614_08290	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC614_08295	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AC614_08345	COG2879	small protein
AC614_08350	COG1966	Carbon starvation protein
AC614_08355	COG1741	Belongs to the pirin family
AC614_08370	COG1741	Belongs to the pirin family
AC614_08375	COG3328	transposase activity
AC614_08385	COG1515	deoxyribonuclease V activity
AC614_08390	COG0588	phosphoglycerate mutase activity
AC614_08400	COG3590	peptidase
AC614_08405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC614_08410	COG2201	protein-glutamate methylesterase activity
AC614_08415	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AC614_08420	COG2199	diguanylate cyclase activity
AC614_08420	COG2200	EAL domain
AC614_08420	COG2202	Pas domain
AC614_08425	COG0835	chemotaxis
AC614_08430	COG0840	transmembrane signaling receptor activity
AC614_08435	COG2198	Histidine kinase
AC614_08435	COG0643	Histidine kinase
AC614_08445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AC614_08455	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AC614_08460	COG0745	RESPONSE REGULATOR receiver
AC614_08465	COG2205	protein histidine kinase activity
AC614_08480	COG4452	Inner membrane protein CreD
AC614_08505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC614_08510	COG0735	belongs to the Fur family
AC614_08525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC614_08530	COG1538	Outer membrane efflux protein
AC614_08535	COG1309	transcriptional regulator
AC614_08545	COG2207	Transcriptional regulator
AC614_08555	COG0583	DNA-binding transcription factor activity
AC614_08560	COG2814	Major facilitator Superfamily
AC614_08565	COG0667	Aldo Keto reductase
AC614_08660	COG1595	DNA-templated transcription, initiation
AC614_08670	COG5001	Diguanylate cyclase
AC614_08670	COG5002	protein histidine kinase activity
AC614_08675	COG1187	pseudouridine synthase activity
AC614_08680	COG3706	GGDEF domain
AC614_08680	COG0745	RESPONSE REGULATOR receiver
AC614_08700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AC614_08705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AC614_08710	COG0475	glutathione-regulated potassium exporter activity
AC614_08715	COG5000	phosphorelay sensor kinase activity
AC614_08715	COG5002	protein histidine kinase activity
AC614_08720	COG0745	RESPONSE REGULATOR receiver
AC614_08725	COG1538	Outer membrane efflux protein
AC614_08750	COG1132	(ABC) transporter
AC614_08790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AC614_08795	COG2155	Conserved Protein
AC614_08810	COG3328	transposase activity
AC614_08835	COG3118	belongs to the thioredoxin family
AC614_08845	COG0495	leucyl-tRNA aminoacylation
AC614_08860	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AC614_08875	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AC614_08890	COG2968	Membrane
AC614_08895	COG0424	maF-like protein
AC614_08900	COG1530	ribonuclease E activity
AC614_08905	COG3164	Protein of unknown function
AC614_08915	COG0312	modulator of DNA gyrase
AC614_08920	COG3028	Belongs to the UPF0307 family
AC614_08925	COG0312	modulator of DNA gyrase
AC614_08935	COG4104	PAAR repeat-containing protein
AC614_08940	COG0142	geranyltranstransferase activity
AC614_08945	COG1722	exodeoxyribonuclease VII activity
AC614_08950	COG0037	tRNA processing
AC614_08955	COG1785	Belongs to the alkaline phosphatase family
AC614_08960	COG1301	dicarboxylic acid transport
AC614_08965	COG4106	trans-aconitate 2-methyltransferase activity
AC614_08975	COG0791	NLP P60 protein
AC614_08980	COG0791	NLP P60 protein
AC614_08985	COG1047	Peptidyl-prolyl cis-trans
AC614_08990	COG2311	Membrane
AC614_08995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC614_09000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC614_09020	COG3590	peptidase
AC614_09025	COG3590	peptidase
AC614_09035	COG3039	Transposase
AC614_09050	COG0489	protein tyrosine kinase activity
AC614_09055	COG0717	Belongs to the dCTP deaminase family
AC614_09100	COG3328	transposase activity
AC614_09105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AC614_09110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC614_09125	COG0494	nUDIX hydrolase
AC614_09130	COG0433	COG0433 Predicted ATPase
AC614_09140	COG0688	phosphatidylethanolamine metabolic process
AC614_09150	COG2890	protein-(glutamine-N5) methyltransferase activity
AC614_09155	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AC614_09160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC614_09165	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AC614_09185	COG0101	tRNA pseudouridine synthase activity
AC614_09190	COG0135	phosphoribosylanthranilate isomerase activity
AC614_09200	COG0133	tryptophan synthase activity
AC614_09210	COG0159	tryptophan synthase activity
AC614_09215	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AC614_09220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC614_09255	COG0300	oxidoreductase activity
AC614_09260	COG0149	triose-phosphate isomerase activity
AC614_09275	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC614_09280	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC614_09285	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC614_09290	COG0649	NAD binding
AC614_09295	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AC614_09300	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AC614_09310	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AC614_09315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC614_09325	COG0713	ATP synthesis coupled electron transport
AC614_09340	COG1007	ATP synthesis coupled electron transport
AC614_09350	COG0779	Required for maturation of 30S ribosomal subunits
AC614_09355	COG0195	Participates in both transcription termination and antitermination
AC614_09360	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AC614_09365	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AC614_09370	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AC614_09375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AC614_09380	COG1185	polyribonucleotide nucleotidyltransferase activity
AC614_09410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AC614_09415	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AC614_09425	COG2095	MarC family integral membrane protein
AC614_09435	COG1611	Belongs to the LOG family
AC614_09485	COG3328	transposase activity
AC614_09495	COG3328	transposase activity
AC614_09500	COG0556	nucleotide-excision repair
AC614_09515	COG3505	Type IV secretory pathway VirD4
AC614_09535	COG2948	multi-organism process
AC614_09595	COG3328	transposase activity
AC614_09605	COG0326	Molecular chaperone. Has ATPase activity
AC614_09610	COG0742	ribosomal rna small subunit methyltransferase
AC614_09615	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AC614_09625	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AC614_09630	COG0405	Gamma-glutamyltransferase
AC614_09640	COG3291	Pkd domain containing protein
AC614_09645	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AC614_09685	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AC614_09690	COG0343	queuine tRNA-ribosyltransferase activity
AC614_09695	COG1862	Preprotein translocase
AC614_09705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AC614_09710	COG3328	transposase activity
AC614_09720	COG3328	transposase activity
AC614_09730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AC614_09730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AC614_09735	COG1105	Belongs to the carbohydrate kinase PfkB family
AC614_09740	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC614_09740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AC614_09745	COG1609	Transcriptional regulator
AC614_09750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC614_09755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC614_09765	COG2902	Dehydrogenase
AC614_09785	COG1902	pentaerythritol trinitrate reductase activity
AC614_09795	COG0300	oxidoreductase activity
AC614_09815	COG0477	Major facilitator Superfamily
AC614_09825	COG5002	protein histidine kinase activity
AC614_09825	COG0784	Response regulator, receiver
AC614_09825	COG2205	protein histidine kinase activity
AC614_09830	COG2733	membrane
AC614_09855	COG0243	molybdopterin cofactor binding
AC614_09865	COG0477	Major facilitator Superfamily
AC614_09870	COG2703	oxygen carrier activity
AC614_09875	COG3706	GGDEF domain
AC614_09875	COG0745	RESPONSE REGULATOR receiver
AC614_09880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC614_09885	COG0174	glutamine synthetase
AC614_09890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AC614_09905	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AC614_09930	COG1176	ABC-type spermidine putrescine transport system, permease component I
AC614_09935	COG1177	transmembrane transport
AC614_09945	COG1012	belongs to the aldehyde dehydrogenase family
AC614_09960	COG4535	Mg2 and Co2 transporter CorC
AC614_09970	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AC614_09980	COG1702	phosphate starvation-inducible protein PhoH
AC614_09985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AC614_10000	COG0741	lytic transglycosylase activity
AC614_10005	COG0723	plastoquinol--plastocyanin reductase activity
AC614_10010	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AC614_10015	COG2857	Cytochrome c1
AC614_10020	COG0625	glutathione transferase activity
AC614_10025	COG2969	positive regulation of protein catabolic process
AC614_10040	COG1201	RNA secondary structure unwinding
AC614_10045	COG2094	Belongs to the DNA glycosylase MPG family
AC614_10050	COG0840	transmembrane signaling receptor activity
AC614_10055	COG0835	chemotaxis
AC614_10095	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AC614_10105	COG1570	exodeoxyribonuclease VII activity
AC614_10110	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AC614_10115	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AC614_10115	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AC614_10120	COG0802	atpase or kinase
AC614_10125	COG0860	N-Acetylmuramoyl-L-alanine amidase
AC614_10130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AC614_10150	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_10155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC614_10160	COG0501	Belongs to the peptidase M48B family
AC614_10165	COG3039	Transposase
AC614_10175	COG2081	HI0933 family
AC614_10180	COG4681	YaeQ
AC614_10190	COG0625	glutathione transferase activity
AC614_10200	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AC614_10205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AC614_10210	COG0513	Belongs to the DEAD box helicase family
AC614_10235	COG0483	inositol monophosphate 1-phosphatase activity
AC614_10250	COG3300	MHYT domain
AC614_10250	COG5001	Diguanylate cyclase
AC614_10255	COG1509	lysine 2,3-aminomutase activity
AC614_10260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AC614_10270	COG0402	S-adenosylhomocysteine deaminase activity
AC614_10275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AC614_10290	COG2963	transposase activity
AC614_10325	COG4302	ethanolamine ammonia-lyase activity
AC614_10345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC614_10350	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AC614_10360	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AC614_10370	COG2166	iron-sulfur cluster assembly
AC614_10375	COG0215	cysteine-tRNA ligase activity
AC614_10385	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AC614_10390	COG0137	argininosuccinate synthase activity
AC614_10405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AC614_10415	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AC614_10420	COG0165	Argininosuccinate lyase
AC614_10430	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AC614_10435	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AC614_10545	COG1294	oxidase, subunit
AC614_10555	COG4988	ABC transporter
AC614_10560	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AC614_10565	COG1278	Cold shock
AC614_10570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC614_10590	COG1138	Cytochrome C-type biogenesis protein
AC614_10595	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AC614_10615	COG4133	protoheme IX ABC transporter activity
AC614_10620	COG0436	Aminotransferase
AC614_10625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC614_10640	COG1187	pseudouridine synthase activity
AC614_10645	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AC614_10650	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AC614_10655	COG2350	Protein conserved in bacteria
AC614_10685	COG1175	transmembrane transport
AC614_10690	COG0395	ABC-type sugar transport system, permease component
AC614_10715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC614_10720	COG2957	Belongs to the agmatine deiminase family
AC614_10730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AC614_10735	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AC614_10740	COG0539	negative regulation of cytoplasmic translation
AC614_10745	COG0776	regulation of translation
AC614_10755	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AC614_10760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AC614_10770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AC614_10775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AC614_10775	COG0475	glutathione-regulated potassium exporter activity
AC614_10785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AC614_10795	COG0519	Catalyzes the synthesis of GMP from XMP
AC614_10795	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AC614_10805	COG3328	transposase activity
AC614_10845	COG2197	response regulator
AC614_10860	COG1335	isochorismatase
AC614_10875	COG2814	Major facilitator Superfamily
AC614_10890	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AC614_10890	COG1648	precorrin-2 dehydrogenase activity
AC614_10905	COG3685	Protein conserved in bacteria
AC614_10925	COG5001	Diguanylate cyclase
AC614_10935	COG4566	intracellular signal transduction
AC614_10970	COG3275	phosphorelay sensor kinase activity
AC614_10975	COG3279	Response regulator of the LytR AlgR family
AC614_11015	COG3920	Histidine kinase
AC614_11035	COG3220	belongs to the UPF0276 family
AC614_11065	COG3039	Transposase
AC614_11120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC614_11140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AC614_11145	COG1136	(ABC) transporter
AC614_11320	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_11325	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AC614_11375	COG0316	Belongs to the HesB IscA family
AC614_11375	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AC614_11380	COG2154	pterin-4-alpha-carbinolamine dehydratase
AC614_11390	COG0428	transporter
AC614_11395	COG3039	Transposase
AC614_11400	COG3064	Membrane
AC614_11410	COG1530	ribonuclease E activity
AC614_11440	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AC614_11465	COG3328	transposase activity
AC614_11480	COG2801	Transposase and inactivated derivatives
AC614_11490	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AC614_11495	COG1061	Type III restriction enzyme res subunit
AC614_11500	COG1002	Type II restriction enzyme, methylase subunits
AC614_11525	COG1192	Involved in chromosome partitioning
AC614_11560	COG0629	single-stranded DNA binding
AC614_11585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AC614_11600	COG2951	lytic endotransglycosylase activity
AC614_11610	COG3039	Transposase
AC614_11615	COG3328	transposase activity
AC614_11810	COG0583	DNA-binding transcription factor activity
AC614_11815	COG0477	Major facilitator Superfamily
AC614_11920	COG3501	Rhs element vgr protein
AC614_11985	COG3501	Rhs element vgr protein
AC614_12035	COG3501	Rhs element vgr protein
AC614_12090	COG0582	viral genome integration into host DNA
AC614_12100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AC614_12105	COG0322	excinuclease ABC activity
AC614_12115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AC614_12120	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AC614_12125	COG1663	tetraacyldisaccharide 4'-kinase activity
AC614_12130	COG1132	(ABC) transporter
AC614_12135	COG0848	biopolymer transport protein
AC614_12140	COG0811	peptide transport
AC614_12155	COG1136	(ABC) transporter
AC614_12160	COG4591	ABC-type transport system involved in lipoprotein release permease component
AC614_12170	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AC614_12175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AC614_12190	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AC614_12200	COG0354	folic acid binding
AC614_12210	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AC614_12215	COG0837	glucose binding
AC614_12220	COG0363	glucosamine-6-phosphate deaminase activity
AC614_12225	COG0129	dihydroxy-acid dehydratase activity
AC614_12230	COG0800	Aldolase
AC614_12300	COG0784	Response regulator, receiver
AC614_12300	COG2205	protein histidine kinase activity
AC614_12305	COG2183	response to ionizing radiation
AC614_12315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC614_12315	COG0723	plastoquinol--plastocyanin reductase activity
AC614_12330	COG3243	poly(R)-hydroxyalkanoic acid synthase
AC614_12340	COG1183	phosphatidylcholine synthase activity
AC614_12345	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_12360	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AC614_12370	COG0668	transmembrane transport
AC614_12375	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AC614_12380	COG0590	tRNA wobble adenosine to inosine editing
AC614_12385	COG1321	iron dependent repressor
AC614_12390	COG1914	H( )-stimulated, divalent metal cation uptake system
AC614_12420	COG0746	molybdenum cofactor guanylyltransferase activity
AC614_12425	COG0303	'Molybdopterin
AC614_12435	COG0708	Exodeoxyribonuclease III
AC614_12470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AC614_12475	COG0303	'Molybdopterin
AC614_12480	COG1160	GTP binding
AC614_12485	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC614_12495	COG1426	Protein conserved in bacteria
AC614_12505	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AC614_12510	COG0105	UTP biosynthetic process
AC614_12520	COG1024	Enoyl-CoA hydratase
AC614_12520	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC614_12525	COG0183	Belongs to the thiolase family
AC614_12530	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AC614_12535	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AC614_12545	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AC614_12555	COG1674	ftsk spoiiie
AC614_12560	COG0492	ferredoxin-NADP+ reductase activity
AC614_12570	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AC614_12575	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AC614_12580	COG0542	response to heat
AC614_12585	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AC614_12595	COG0482	sulfurtransferase activity
AC614_12600	COG2915	High frequency lysogenization protein hflD homolog
AC614_12630	COG5002	protein histidine kinase activity
AC614_12650	COG0784	Response regulator, receiver
AC614_12650	COG0835	chemotaxis
AC614_12660	COG1558	bacterial-type flagellum-dependent cell motility
AC614_12665	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AC614_12670	COG1749	Flagellar hook protein flgE
AC614_12675	COG4787	bacterial-type flagellum-dependent cell motility
AC614_12680	COG4786	Flagellar basal body rod
AC614_12685	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AC614_12690	COG1706	bacterial-type flagellum-dependent cell motility
AC614_12695	COG1705	Flagellar rod assembly protein muramidase FlgJ
AC614_12695	COG3951	Flagellar rod assembly protein muramidase FlgJ
AC614_12705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AC614_12710	COG3039	Transposase
AC614_12720	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AC614_12750	COG2201	protein-glutamate methylesterase activity
AC614_12755	COG2204	response regulator
AC614_12770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC614_12775	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_12780	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_12810	COG3039	Transposase
AC614_12820	COG0582	viral genome integration into host DNA
AC614_12830	COG3040	lipid binding
AC614_12840	COG1960	acyl-CoA dehydrogenase activity
AC614_12850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AC614_12870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC614_12875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC614_12880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC614_12915	COG0438	transferase activity, transferring glycosyl groups
AC614_12920	COG0438	transferase activity, transferring glycosyl groups
AC614_12965	COG0776	regulation of translation
AC614_12970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC614_12970	COG0072	phenylalanine-tRNA ligase activity
AC614_12975	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AC614_12980	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AC614_12985	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AC614_12990	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AC614_12995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AC614_13010	COG2190	(PTS) system
AC614_13010	COG2211	Major facilitator Superfamily
AC614_13040	COG3039	Transposase
AC614_13045	COG3039	Transposase
AC614_13065	COG0366	Alpha amylase catalytic
AC614_13080	COG3039	Transposase
AC614_13165	COG0531	amino acid
AC614_13180	COG0006	proline dipeptidase activity
AC614_13190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC614_13205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC614_13210	COG3938	Belongs to the proline racemase family
AC614_13220	COG0552	protein localization to endoplasmic reticulum
AC614_13225	COG1194	a g-specific adenine glycosylase
AC614_13230	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AC614_13235	COG4191	Histidine kinase
AC614_13235	COG0784	Response regulator, receiver
AC614_13270	COG3039	Transposase
AC614_13285	COG3039	Transposase
AC614_13305	COG1677	Flagellar hook-basal body complex protein FliE
AC614_13355	COG3190	flagellar
AC614_13365	COG1987	bacterial-type flagellum assembly
AC614_13370	COG1684	flagellar biosynthetic protein fliR
AC614_13385	COG5001	Diguanylate cyclase
AC614_13385	COG3300	MHYT domain
AC614_13400	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AC614_13410	COG0455	bacterial-type flagellum organization
AC614_13430	COG0643	Histidine kinase
AC614_13430	COG2198	Histidine kinase
AC614_13460	COG3039	Transposase
AC614_13485	COG3328	transposase activity
AC614_13500	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AC614_13505	COG1360	Flagellar Motor Protein
AC614_13510	COG1192	Involved in chromosome partitioning
AC614_13515	COG0835	chemotaxis
AC614_13525	COG0745	RESPONSE REGULATOR receiver
AC614_13535	COG0840	transmembrane signaling receptor activity
AC614_13545	COG0840	transmembrane signaling receptor activity
AC614_13545	COG0840	transmembrane signaling receptor activity
AC614_13550	COG0840	transmembrane signaling receptor activity
AC614_13555	COG0840	transmembrane signaling receptor activity
AC614_13560	COG0840	transmembrane signaling receptor activity
AC614_13570	COG0840	transmembrane signaling receptor activity
AC614_13580	COG0840	transmembrane signaling receptor activity
AC614_13585	COG0840	transmembrane signaling receptor activity
AC614_13590	COG0840	transmembrane signaling receptor activity
AC614_13595	COG0840	transmembrane signaling receptor activity
AC614_13610	COG0835	chemotaxis
AC614_13620	COG0840	transmembrane signaling receptor activity
AC614_13630	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AC614_13635	COG2201	protein-glutamate methylesterase activity
AC614_13645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC614_13680	COG0318	PFAM AMP-dependent synthetase and ligase
AC614_13685	COG1024	Enoyl-CoA hydratase
AC614_13690	COG2198	Histidine kinase
AC614_13690	COG0784	Response regulator, receiver
AC614_13690	COG2205	protein histidine kinase activity
AC614_13705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AC614_13710	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AC614_13715	COG3279	Response regulator of the LytR AlgR family
AC614_13725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AC614_13735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC614_13740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AC614_13750	COG0505	Belongs to the CarA family
AC614_13755	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AC614_13760	COG2258	MOSC domain
AC614_13765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC614_13810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AC614_13830	COG0277	FAD linked oxidase domain protein
AC614_13835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AC614_13845	COG0531	amino acid
AC614_13850	COG0531	amino acid
AC614_13855	COG0235	Class ii aldolase
AC614_13860	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AC614_13865	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AC614_13880	COG0140	phosphoribosyl-ATP diphosphatase activity
AC614_13880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AC614_13885	COG0107	imidazoleglycerol-phosphate synthase activity
AC614_13890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AC614_13895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AC614_13900	COG0131	Imidazoleglycerol-phosphate dehydratase
AC614_13900	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AC614_13905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC614_13910	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AC614_13915	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AC614_13925	COG0124	histidyl-tRNA synthetase
AC614_13930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC614_13965	COG2963	transposase activity
AC614_13970	COG3328	transposase activity
AC614_13980	COG3039	Transposase
AC614_13995	COG3328	transposase activity
AC614_14025	COG3328	transposase activity
AC614_14050	COG0726	polysaccharide deacetylase
AC614_14050	COG1649	PFAM Uncharacterised BCR, COG1649
AC614_14055	COG1215	transferase activity, transferring glycosyl groups
AC614_14070	COG1012	belongs to the aldehyde dehydrogenase family
AC614_14085	COG0167	dihydroorotate dehydrogenase activity
AC614_14090	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AC614_14095	COG0697	spore germination
AC614_14100	COG1794	racemase activity, acting on amino acids and derivatives
AC614_14115	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AC614_14125	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AC614_14135	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AC614_14140	COG4251	negative regulation of phosphorylation
AC614_14140	COG5001	Diguanylate cyclase
AC614_14140	COG3706	GGDEF domain
AC614_14140	COG2203	Gaf domain
AC614_14150	COG1472	Belongs to the glycosyl hydrolase 3 family
AC614_14175	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AC614_14180	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AC614_14185	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AC614_14205	COG1469	GTP cyclohydrolase I activity
AC614_14210	COG0860	N-Acetylmuramoyl-L-alanine amidase
AC614_14220	COG3039	Transposase
AC614_14255	COG3328	transposase activity
AC614_14265	COG1070	Carbohydrate kinase
AC614_14275	COG1501	Belongs to the glycosyl hydrolase 31 family
AC614_14315	COG0800	Aldolase
AC614_14320	COG4948	Mandelate Racemase Muconate Lactonizing
AC614_14330	COG3734	2-keto-3-deoxy-galactonokinase
AC614_14335	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AC614_14345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC614_14360	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AC614_14365	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AC614_14380	COG0351	phosphomethylpyrimidine kinase
AC614_14405	COG0583	DNA-binding transcription factor activity
AC614_14415	COG1741	Belongs to the pirin family
AC614_14430	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AC614_14435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AC614_14440	COG2137	regulation of response to DNA damage stimulus
AC614_14450	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AC614_14455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC614_14465	COG1546	Belongs to the CinA family
AC614_14470	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AC614_14475	COG1923	regulation of RNA biosynthetic process
AC614_14480	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AC614_14485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AC614_14490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AC614_14495	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AC614_14500	COG1534	Rna-binding protein
AC614_14515	COG1238	metal cluster binding
AC614_14520	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AC614_14525	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AC614_14530	COG2840	Smr protein MutS2
AC614_14535	COG0585	pseudouridine synthase activity
AC614_14540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AC614_14545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AC614_14550	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AC614_14555	COG0148	phosphopyruvate hydratase activity
AC614_14570	COG0504	CTP synthase activity
AC614_14595	COG0306	phosphate transporter
AC614_14605	COG1253	flavin adenine dinucleotide binding
AC614_14640	COG1136	(ABC) transporter
AC614_14665	COG2264	protein methyltransferase activity
AC614_14695	COG2244	polysaccharide biosynthetic process
AC614_14745	COG1595	DNA-templated transcription, initiation
AC614_14760	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AC614_14770	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AC614_14780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC614_14795	COG4191	Histidine kinase
AC614_14795	COG0784	Response regulator, receiver
AC614_14800	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AC614_14805	COG0784	Response regulator, receiver
AC614_14805	COG5002	protein histidine kinase activity
AC614_14805	COG2205	protein histidine kinase activity
AC614_14835	COG0840	transmembrane signaling receptor activity
AC614_14850	COG3328	transposase activity
AC614_14870	COG0583	DNA-binding transcription factor activity
AC614_14875	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AC614_14880	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AC614_14895	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AC614_14900	COG0077	Prephenate dehydratase
AC614_14900	COG1605	Chorismate mutase
AC614_14905	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AC614_14910	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AC614_14915	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AC614_14955	COG1228	amidohydrolase
AC614_14960	COG2986	histidine ammonia-lyase
AC614_14970	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AC614_14980	COG4993	Dehydrogenase
AC614_14990	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AC614_15000	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AC614_15005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AC614_15010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC614_15020	COG3115	cell septum assembly
AC614_15035	COG0359	binds to the 23S rRNA
AC614_15040	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AC614_15045	COG0360	Binds together with S18 to 16S ribosomal RNA
AC614_15050	COG0316	Belongs to the HesB IscA family
AC614_15055	COG0017	Asparaginyl-tRNA synthetase
AC614_15090	COG3039	Transposase
AC614_15140	COG0288	reversible hydration of carbon dioxide
AC614_15145	COG0662	Cupin 2, conserved barrel domain protein
AC614_15155	COG3844	kynureninase activity
AC614_15160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC614_15165	COG2925	Exonuclease
AC614_15185	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AC614_15190	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AC614_15190	COG0116	Belongs to the methyltransferase superfamily
AC614_15230	COG0494	nUDIX hydrolase
AC614_15240	COG1024	Enoyl-CoA hydratase
AC614_15250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AC614_15255	COG0659	secondary active sulfate transmembrane transporter activity
AC614_15280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AC614_15285	COG0573	inorganic phosphate transmembrane transporter activity
AC614_15290	COG0581	inorganic phosphate transmembrane transporter activity
AC614_15295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AC614_15300	COG0704	Plays a role in the regulation of phosphate uptake
AC614_15310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AC614_15320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC614_15330	COG0557	exoribonuclease II activity
AC614_15345	COG1960	acyl-CoA dehydrogenase activity
AC614_15350	COG1960	acyl-CoA dehydrogenase activity
AC614_15360	COG0646	methionine synthase
AC614_15360	COG1410	methionine synthase
AC614_15365	COG1410	methionine synthase
AC614_15365	COG0646	methionine synthase
AC614_15375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC614_15400	COG2900	Belongs to the SlyX family
AC614_15415	COG0386	Belongs to the glutathione peroxidase family
AC614_15420	COG1725	Transcriptional regulator
AC614_15425	COG1131	(ABC) transporter
AC614_15455	COG1253	flavin adenine dinucleotide binding
AC614_15480	COG2850	peptidyl-arginine hydroxylation
AC614_15515	COG1132	(ABC) transporter
AC614_15520	COG0583	DNA-binding transcription factor activity
AC614_15550	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AC614_15555	COG0484	heat shock protein binding
AC614_15560	COG0443	Heat shock 70 kDa protein
AC614_15565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AC614_15570	COG1420	regulation of RNA biosynthetic process
AC614_15575	COG0497	DNA recombination
AC614_15585	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC614_15600	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AC614_15615	COG3328	transposase activity
AC614_15645	COG3328	transposase activity
AC614_15660	COG3706	GGDEF domain
AC614_15670	COG3706	GGDEF domain
AC614_15705	COG0583	DNA-binding transcription factor activity
AC614_15715	COG0415	Belongs to the DNA photolyase family
AC614_15720	COG0305	Participates in initiation and elongation during chromosome replication
AC614_15730	COG0367	asparagine synthase
AC614_15745	COG1960	acyl-CoA dehydrogenase activity
AC614_15760	COG0084	hydrolase, TatD family'
AC614_15765	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AC614_15820	COG0386	Belongs to the glutathione peroxidase family
AC614_15825	COG0339	signal peptide processing
AC614_15855	COG3104	oligopeptide transport
AC614_15880	COG2814	Major facilitator Superfamily
AC614_15885	COG1566	PFAM secretion protein HlyD family protein
AC614_15910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AC614_15925	COG4774	siderophore transport
AC614_15935	COG0367	asparagine synthase
AC614_15940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC614_15945	COG1393	Belongs to the ArsC family
AC614_15955	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AC614_15960	COG0024	Methionine aminopeptidase
AC614_15995	COG0052	Belongs to the universal ribosomal protein uS2 family
AC614_16000	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AC614_16005	COG3706	GGDEF domain
AC614_16005	COG0745	RESPONSE REGULATOR receiver
AC614_16010	COG0528	UMP kinase activity
AC614_16015	COG0233	cytoplasmic translational termination
AC614_16020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AC614_16025	COG0575	Belongs to the CDS family
AC614_16030	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AC614_16035	COG0750	zinc metalloprotease
AC614_16050	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC614_16055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC614_16060	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC614_16065	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC614_16080	COG0825	malonyl-CoA metabolic process
AC614_16115	COG1695	Transcriptional regulator
AC614_16140	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AC614_16150	COG2040	homocysteine
AC614_16155	COG0833	amino acid
AC614_16160	COG0346	lactoylglutathione lyase activity
AC614_16165	COG1131	(ABC) transporter
AC614_16175	COG3039	Transposase
AC614_16190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC614_16190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC614_16220	COG1595	DNA-templated transcription, initiation
AC614_16245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AC614_16260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AC614_16265	COG0251	oxidation-reduction process
AC614_16275	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AC614_16275	COG0392	lysyltransferase activity
AC614_16310	COG2814	Major facilitator Superfamily
AC614_16315	COG1902	pentaerythritol trinitrate reductase activity
AC614_16320	COG2824	Alkylphosphonate utilization operon protein PhnA
AC614_16330	COG1047	Peptidyl-prolyl cis-trans
AC614_16335	COG1077	Cell shape determining protein MreB Mrl
AC614_16350	COG3328	transposase activity
AC614_16355	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AC614_16365	COG5487	UPF0391 membrane protein
AC614_16370	COG1451	nucleotide metabolic process
AC614_16385	COG0183	Belongs to the thiolase family
AC614_16400	COG3706	GGDEF domain
AC614_16400	COG0745	RESPONSE REGULATOR receiver
AC614_16415	COG1793	dna ligase
AC614_16415	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AC614_16425	COG1793	dna ligase
AC614_16430	COG1201	RNA secondary structure unwinding
AC614_16440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC614_16445	COG1278	Cold shock
AC614_16450	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AC614_16460	COG1472	Belongs to the glycosyl hydrolase 3 family
AC614_16465	COG3046	protein related to deoxyribodipyrimidine photolyase
AC614_16470	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AC614_16475	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AC614_16485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AC614_16495	COG1381	Involved in DNA repair and RecF pathway recombination
AC614_16500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AC614_16505	COG0571	ribonuclease III activity
AC614_16520	COG0481	GTPase activity
AC614_16525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC614_16540	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC614_16540	COG1024	Enoyl-CoA hydratase
AC614_16550	COG3039	Transposase
AC614_16565	COG0745	RESPONSE REGULATOR receiver
AC614_16575	COG0189	ligase activity
AC614_16585	COG3039	Transposase
AC614_16610	COG3328	transposase activity
AC614_16625	COG3039	Transposase
AC614_16635	COG3039	Transposase
AC614_16650	COG3039	Transposase
AC614_16665	COG2003	Belongs to the UPF0758 family
AC614_16670	COG3328	transposase activity
AC614_16685	COG3328	transposase activity
AC614_16735	COG3328	transposase activity
AC614_16765	COG3328	transposase activity
AC614_16775	COG3328	transposase activity
AC614_16785	COG3328	transposase activity
AC614_16830	COG2022	thiamine diphosphate biosynthetic process
AC614_16835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AC614_16840	COG3273	potassium ion transport
AC614_16840	COG0471	metal ion transport
AC614_16865	COG1970	mechanosensitive ion channel activity
AC614_16880	COG1609	Transcriptional regulator
AC614_16890	COG3250	beta-galactosidase activity
AC614_16895	COG4948	Mandelate Racemase Muconate Lactonizing
AC614_16905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC614_16915	COG0308	aminopeptidase N
AC614_16920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC614_16930	COG3039	Transposase
AC614_16935	COG2895	sulfate adenylyltransferase (ATP) activity
AC614_16935	COG0529	Catalyzes the synthesis of activated sulfate
AC614_16940	COG0175	sulfate reduction
AC614_16945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AC614_16950	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC614_16955	COG0175	sulfate reduction
AC614_16960	COG3039	Transposase
AC614_17010	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AC614_17015	COG3588	fructose-bisphosphate aldolase
AC614_17020	COG0469	pyruvate kinase activity
AC614_17030	COG0126	phosphoglycerate kinase activity
AC614_17050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AC614_17060	COG3047	cAMP biosynthetic process
AC614_17065	COG3047	cAMP biosynthetic process
AC614_17075	COG3453	Protein conserved in bacteria
AC614_17075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC614_17080	COG0725	ABC transporter, periplasmic molybdate-binding protein
AC614_17085	COG4149	molybdate abc transporter
AC614_17125	COG1376	ErfK ybiS ycfS ynhG family protein
AC614_17130	COG0739	heme binding
AC614_17135	COG4773	Receptor
AC614_17155	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AC614_17160	COG1301	dicarboxylic acid transport
AC614_17170	COG2304	oxidoreductase activity
AC614_17190	COG0714	Associated with various cellular activities
AC614_17220	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AC614_17235	COG0254	rRNA binding
AC614_17245	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AC614_17255	COG2721	sulfolactate sulfo-lyase activity
AC614_17270	COG2271	Major facilitator Superfamily
AC614_17285	COG0583	DNA-binding transcription factor activity
AC614_17290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AC614_17295	COG1758	RNA polymerase activity
AC614_17305	COG1561	YicC-like family, N-terminal region
AC614_17310	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AC614_17320	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AC614_17325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AC614_17340	COG0006	proline dipeptidase activity
AC614_17350	COG0006	proline dipeptidase activity
AC614_17355	COG3079	Belongs to the UPF0149 family
AC614_17370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AC614_17380	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AC614_17390	COG2912	Transglutaminase-like superfamily
AC614_17395	COG1773	rubredoxin
AC614_17400	COG0352	thiamine-phosphate diphosphorylase activity
AC614_17410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AC614_17425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC614_17455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AC614_17460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC614_17465	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_17475	COG0671	phosphoesterase, PA-phosphatase related
AC614_17480	COG3781	membrane
AC614_17490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AC614_17495	COG0563	adenylate kinase activity
AC614_17510	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AC614_17520	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AC614_17535	COG3328	transposase activity
AC614_17550	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AC614_17560	COG0840	transmembrane signaling receptor activity
AC614_17565	COG0405	Gamma-glutamyltransferase
AC614_17570	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AC614_17590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AC614_17595	COG0473	3-isopropylmalate dehydrogenase activity
AC614_17600	COG0066	3-isopropylmalate dehydratase activity
AC614_17605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AC614_17625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AC614_17630	COG1538	Outer membrane efflux protein
AC614_17635	COG1519	Transferase
AC614_17640	COG1560	Kdo2-lipid A biosynthetic process
AC614_17665	COG0281	malic enzyme
AC614_17665	COG0280	phosphate acetyltransferase
AC614_17670	COG1301	dicarboxylic acid transport
AC614_17695	COG0583	DNA-binding transcription factor activity
AC614_17705	COG0667	Aldo Keto reductase
AC614_17720	COG2197	response regulator
AC614_17725	COG1840	ABC-type Fe3 transport system, periplasmic component
AC614_17730	COG0642	Histidine kinase
AC614_17745	COG2851	Citrate transporter
AC614_17750	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_17755	COG1609	Transcriptional regulator
AC614_17760	COG2211	Major facilitator Superfamily
AC614_17785	COG1162	GTPase activity
AC614_17790	COG0436	Aminotransferase
AC614_17805	COG0726	polysaccharide deacetylase
AC614_17810	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AC614_17825	COG3964	amidohydrolase
AC614_17830	COG0402	S-adenosylhomocysteine deaminase activity
AC614_17850	COG3039	Transposase
AC614_17855	COG1307	EDD domain protein, DegV family
AC614_17860	COG0242	peptide deformylase activity
AC614_17885	COG0457	Tetratricopeptide repeat
AC614_17890	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AC614_17895	COG1215	transferase activity, transferring glycosyl groups
AC614_17900	COG1215	transferase activity, transferring glycosyl groups
AC614_17915	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AC614_17965	COG2188	Transcriptional regulator
AC614_17980	COG1450	Type ii and iii secretion system protein
AC614_17995	COG3166	PFAM Fimbrial assembly family protein
AC614_18000	COG3156	type II secretion system protein K
AC614_18005	COG4795	General secretion pathway protein
AC614_18010	COG2165	general secretion pathway protein
AC614_18015	COG4970	Tfp pilus assembly protein FimT
AC614_18020	COG2165	general secretion pathway protein
AC614_18025	COG1459	type II secretion system
AC614_18030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AC614_18035	COG1404	Belongs to the peptidase S8 family
AC614_18045	COG1404	Belongs to the peptidase S8 family
AC614_18050	COG5295	Hep Hag repeat protein
AC614_18060	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AC614_18060	COG0047	phosphoribosylformylglycinamidine synthase activity
AC614_18065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC614_18070	COG4974	Belongs to the 'phage' integrase family
AC614_18085	COG0795	lipopolysaccharide-transporting ATPase activity
AC614_18095	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AC614_18110	COG0525	valine-tRNA ligase activity
AC614_18130	COG3328	transposase activity
AC614_18155	COG1183	phosphatidylcholine synthase activity
AC614_18165	COG0442	prolyl-tRNA aminoacylation
AC614_18180	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AC614_18185	COG1127	ABC transporter
AC614_18190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AC614_18190	COG3218	ABC-type transport auxiliary lipoprotein component
AC614_18220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC614_18225	COG0662	Cupin 2, conserved barrel domain protein
AC614_18225	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AC614_18255	COG2086	electron transfer activity
AC614_18270	COG0463	Glycosyl transferase, family 2
AC614_18300	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AC614_18305	COG0438	transferase activity, transferring glycosyl groups
AC614_18325	COG0438	transferase activity, transferring glycosyl groups
AC614_18330	COG0626	cystathionine gamma-synthase activity
AC614_18360	COG0625	glutathione transferase activity
AC614_18370	COG0513	Belongs to the DEAD box helicase family
AC614_18380	COG4771	TonB-dependent receptor
AC614_18385	COG0720	synthase
AC614_18415	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AC614_18425	COG1956	GAF domain-containing protein
AC614_18435	COG2819	hydrolase of the alpha beta superfamily
AC614_18445	COG0546	phosphoglycolate phosphatase activity
AC614_18450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AC614_18455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC614_18470	COG0339	signal peptide processing
AC614_18520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AC614_18525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC614_18530	COG1136	(ABC) transporter
AC614_18535	COG0577	efflux transmembrane transporter activity
AC614_18540	COG0577	efflux transmembrane transporter activity
AC614_18540	COG1136	(ABC) transporter
AC614_18550	COG2204	response regulator
AC614_18555	COG4191	Histidine kinase
AC614_18560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AC614_18580	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AC614_18585	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AC614_18590	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AC614_18595	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AC614_18600	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AC614_18605	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AC614_18615	COG0356	it plays a direct role in the translocation of protons across the membrane
AC614_18635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC614_18645	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC614_18685	COG2011	ABC-type metal ion transport system permease component
AC614_18690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AC614_18695	COG0697	spore germination
AC614_18700	COG1666	GTP binding
AC614_18710	COG0784	Response regulator, receiver
AC614_18710	COG2198	Histidine kinase
AC614_18710	COG5002	protein histidine kinase activity
AC614_18745	COG1187	pseudouridine synthase activity
AC614_18750	COG2813	Specifically methylates the guanine in position
AC614_18770	COG2202	Pas domain
AC614_18770	COG2205	protein histidine kinase activity
AC614_18790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AC614_18795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC614_18800	COG1522	sequence-specific DNA binding
AC614_18855	COG1131	(ABC) transporter
AC614_18860	COG0025	NhaP-type Na H and K H
AC614_18865	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AC614_18870	COG1573	uracil-dna glycosylase
AC614_18880	COG3384	dioxygenase
AC614_18890	COG0583	DNA-binding transcription factor activity
AC614_18900	COG0667	Aldo Keto reductase
AC614_18910	COG3590	peptidase
AC614_18925	COG0531	amino acid
AC614_18940	COG2972	Histidine kinase
AC614_18955	COG3685	Protein conserved in bacteria
AC614_18960	COG3546	catalase activity
AC614_18995	COG2204	response regulator
AC614_19010	COG1271	oxidase subunit
AC614_19015	COG1294	oxidase, subunit
AC614_19030	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_19035	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AC614_19055	COG1132	(ABC) transporter
AC614_19070	COG1063	alcohol dehydrogenase
AC614_19145	COG0251	oxidation-reduction process
AC614_19175	COG0583	DNA-binding transcription factor activity
AC614_19180	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AC614_19210	COG0659	secondary active sulfate transmembrane transporter activity
AC614_19220	COG0024	Methionine aminopeptidase
AC614_19245	COG3039	Transposase
AC614_19260	COG3039	Transposase
AC614_19270	COG3328	transposase activity
AC614_19285	COG3328	transposase activity
AC614_19305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AC614_19310	COG1490	D-aminoacyl-tRNA deacylase activity
AC614_19315	COG1560	Kdo2-lipid A biosynthetic process
AC614_19365	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AC614_19365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC614_19370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AC614_19375	COG0242	peptide deformylase activity
AC614_19380	COG1652	LysM domain
AC614_19385	COG0758	DNA mediated transformation
AC614_19405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AC614_19405	COG1754	DNA topoisomerase type I activity
AC614_19410	COG0009	L-threonylcarbamoyladenylate synthase
AC614_19425	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_19440	COG0616	signal peptide processing
AC614_19445	COG0534	Mate efflux family protein
AC614_19465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AC614_19470	COG0625	glutathione transferase activity
AC614_19485	COG1252	NADH dehydrogenase
AC614_19495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AC614_19500	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AC614_19505	COG2201	protein-glutamate methylesterase activity
AC614_19510	COG2177	Part of the ABC transporter FtsEX involved in
AC614_19515	COG2884	Cell division ATP-binding protein ftsE
AC614_19520	COG0513	Belongs to the DEAD box helicase family
AC614_19525	COG3118	belongs to the thioredoxin family
AC614_19530	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AC614_19535	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AC614_19540	COG0583	DNA-binding transcription factor activity
AC614_19560	COG1652	LysM domain
AC614_19565	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AC614_19565	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AC614_19570	COG1473	amidohydrolase
AC614_19575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC614_19580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC614_19600	COG5383	Protein conserved in bacteria
AC614_19640	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AC614_19645	COG3023	N-Acetylmuramoyl-L-alanine amidase
AC614_19655	COG4948	Mandelate Racemase Muconate Lactonizing
AC614_19665	COG0531	amino acid
AC614_19685	COG4682	membrane
AC614_19700	COG3328	transposase activity
AC614_19705	COG2133	pyrroloquinoline quinone binding
AC614_19715	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AC614_19720	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AC614_19725	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AC614_19730	COG1610	YqeY-like protein
AC614_19735	COG1295	ribonuclease BN
AC614_19740	COG0358	DNA primase activity
AC614_19755	COG0109	protoheme IX farnesyltransferase activity
AC614_19785	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AC614_19800	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AC614_19845	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AC614_19850	COG0739	heme binding
AC614_19855	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AC614_19865	COG2223	nitrite transmembrane transporter activity
AC614_19870	COG0708	Exodeoxyribonuclease III
AC614_19875	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AC614_19885	COG1192	Involved in chromosome partitioning
AC614_19890	COG1475	DNA binding
AC614_19910	COG0463	Glycosyl transferase, family 2
AC614_19930	COG0756	dUTP diphosphatase activity
AC614_19935	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AC614_19940	COG2003	Belongs to the UPF0758 family
AC614_19945	COG0018	arginyl-trna synthetase
AC614_19960	COG4221	oxidoreductase activity
AC614_19965	COG2755	lipolytic protein G-D-S-L family
AC614_19965	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AC614_19980	COG1166	arginine decarboxylase activity
AC614_19985	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AC614_20010	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AC614_20010	COG3291	Pkd domain containing protein
AC614_20025	COG0606	chelatase, subunit chli
AC614_20040	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AC614_20070	COG3039	Transposase
AC614_20080	COG1690	Belongs to the RtcB family
AC614_20120	COG1090	epimerase
AC614_20125	COG0745	RESPONSE REGULATOR receiver
AC614_20130	COG0642	Histidine kinase
AC614_20150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC614_20175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AC614_20180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AC614_20185	COG3328	transposase activity
AC614_20190	COG3328	transposase activity
AC614_20200	COG0753	catalase activity
AC614_20215	COG2197	response regulator
AC614_20220	COG4585	Histidine kinase
AC614_20225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC614_20230	COG1136	(ABC) transporter
AC614_20255	COG0697	spore germination
AC614_20275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC614_20280	COG0180	Tryptophanyl-tRNA synthetase
AC614_20285	COG3328	transposase activity
AC614_20290	COG3237	CsbD-like
AC614_20330	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AC614_20345	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AC614_20375	COG2205	protein histidine kinase activity
AC614_20380	COG0745	RESPONSE REGULATOR receiver
AC614_20390	COG3039	Transposase
AC614_20395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AC614_20415	COG1199	ATP-dependent helicase activity
AC614_20430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AC614_20490	COG0625	glutathione transferase activity
AC614_20530	COG4555	ABC transporter
AC614_20540	COG1476	TRANSCRIPTIONal
AC614_20560	COG1230	cation diffusion facilitator family transporter
AC614_20570	COG4774	siderophore transport
AC614_20585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AC614_20590	COG1131	(ABC) transporter
AC614_20595	COG0842	Transport permease protein
AC614_20600	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AC614_20630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AC614_20635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AC614_20645	COG1042	CoA-binding domain protein
AC614_20645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AC614_20645	COG0045	succinate-CoA ligase (ADP-forming) activity
AC614_20650	COG2239	Acts as a magnesium transporter
AC614_20665	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AC614_20670	COG3387	PFAM Glycoside hydrolase 15-related
AC614_20685	COG3100	YcgL domain-containing protein
AC614_20690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AC614_20700	COG0463	Glycosyl transferase, family 2
AC614_20710	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_20745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC614_20760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AC614_20785	COG1506	peptidase
AC614_20785	COG0823	Involved in the tonB-independent uptake of proteins
AC614_20785	COG4946	Tricorn protease homolog
AC614_20790	COG3039	Transposase
AC614_20805	COG0408	coproporphyrinogen oxidase activity
AC614_20840	COG0515	serine threonine protein kinase
AC614_20880	COG3501	Rhs element vgr protein
AC614_20905	COG1595	DNA-templated transcription, initiation
AC614_21010	COG0210	DNA helicase
AC614_21020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC614_21025	COG0583	DNA-binding transcription factor activity
AC614_21030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AC614_21045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AC614_21050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AC614_21060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC614_21080	COG0357	Ribosomal RNA small subunit methyltransferase G
AC614_21085	COG3540	Alkaline phosphatase
AC614_21095	COG2091	lysine biosynthetic process via aminoadipic acid
AC614_21115	COG0708	Exodeoxyribonuclease III
AC614_21120	COG1940	carbohydrate kinase activity
AC614_21120	COG1846	Transcriptional regulator
AC614_21130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC614_21140	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC614_21145	COG3162	membrane
AC614_21155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC614_21205	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_21210	COG0179	Fumarylacetoacetate (FAA) hydrolase
AC614_21215	COG4948	Mandelate Racemase Muconate Lactonizing
AC614_21220	COG3254	rhamnose metabolic process
AC614_21225	COG0738	Major facilitator superfamily
AC614_21230	COG1414	Transcriptional regulator
AC614_21235	COG1971	Probably functions as a manganese efflux pump
AC614_21240	COG2205	protein histidine kinase activity
AC614_21250	COG3459	Glycosyltransferase 36 associated
AC614_21255	COG2211	Major facilitator Superfamily
AC614_21260	COG3265	gluconokinase activity
AC614_21265	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC614_21285	COG2911	Protein conserved in bacteria
AC614_21290	COG0729	surface antigen
AC614_21300	COG3039	Transposase
AC614_21305	COG3039	Transposase
AC614_21310	COG3039	Transposase
AC614_21340	COG0752	glycyl-tRNA synthetase alpha subunit
AC614_21345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AC614_21355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AC614_21355	COG0519	Catalyzes the synthesis of GMP from XMP
AC614_21365	COG0805	protein transport
AC614_21370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC614_21375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC614_21385	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AC614_21405	COG2974	May be involved in recombination
AC614_21410	COG0037	tRNA processing
AC614_21415	COG2115	Belongs to the xylose isomerase family
AC614_21425	COG3661	Belongs to the glycosyl hydrolase 67 family
AC614_21435	COG4948	Mandelate Racemase Muconate Lactonizing
AC614_21445	COG1472	Belongs to the glycosyl hydrolase 3 family
AC614_21450	COG0246	Mannitol dehydrogenase
AC614_21520	COG3039	Transposase
AC614_21525	COG3386	PFAM SMP-30 Gluconolaconase
AC614_21535	COG3250	beta-galactosidase activity
AC614_21540	COG1904	glucuronate isomerase
AC614_21560	COG3693	PFAM glycoside hydrolase, family 10
AC614_21575	COG2211	Major facilitator Superfamily
AC614_21610	COG1028	Short-chain dehydrogenase reductase Sdr
AC614_21610	COG3321	synthase
AC614_21610	COG0604	alcohol dehydrogenase
AC614_21615	COG2937	Belongs to the GPAT DAPAT family
AC614_21650	COG0284	orotidine-5'-phosphate decarboxylase activity
AC614_21655	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AC614_21660	COG3132	Protein of unknown function, DUF480
AC614_21675	COG0210	DNA helicase
AC614_21680	COG1435	thymidine kinase activity
AC614_21690	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AC614_21700	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AC614_21730	COG3135	benzoate transporter
AC614_21750	COG0676	glucose-6-phosphate 1-epimerase activity
AC614_21760	COG3012	SEC-C Motif Domain Protein
AC614_21765	COG0730	response to heat
AC614_21775	COG3328	transposase activity
AC614_21795	COG0302	gtp cyclohydrolase
AC614_21810	COG1566	PFAM secretion protein HlyD family protein
AC614_21820	COG1289	transmembrane transporter activity
AC614_21825	COG0477	Major facilitator Superfamily
AC614_21835	COG0583	DNA-binding transcription factor activity
AC614_21840	COG4221	oxidoreductase activity
AC614_21850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC614_21870	COG3328	transposase activity
AC614_21895	COG0564	pseudouridine synthase activity
AC614_21920	COG3039	Transposase
AC614_21935	COG3328	transposase activity
AC614_21955	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AC614_21960	COG1074	ATP-dependent DNA helicase activity
AC614_21965	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AC614_22000	COG1127	ABC transporter
AC614_22005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AC614_22010	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AC614_22025	COG2853	Lipoprotein
AC614_22035	COG0386	Belongs to the glutathione peroxidase family
AC614_22060	COG0625	glutathione transferase activity
AC614_22110	COG3077	Addiction module antitoxin, RelB DinJ family
AC614_22115	COG3041	Addiction module toxin RelE StbE family
AC614_22170	COG0840	transmembrane signaling receptor activity
AC614_22200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AC614_22205	COG4691	Plasmid stability protein
AC614_22235	COG1192	Involved in chromosome partitioning
AC614_22260	COG3537	Alpha-1,2-mannosidase
AC614_22280	COG1929	Belongs to the glycerate kinase type-1 family
AC614_22285	COG2271	Major facilitator Superfamily
AC614_22300	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AC614_22305	COG0861	Integral membrane protein TerC family
AC614_22315	COG0584	glycerophosphoryl diester phosphodiesterase
AC614_22330	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AC614_22340	COG0706	membrane insertase activity
AC614_22345	COG0594	ribonuclease P activity
AC614_22350	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AC614_22410	COG3328	transposase activity
AC614_22415	COG3328	transposase activity
AC614_22455	COG3328	transposase activity
AC614_22510	COG2951	lytic endotransglycosylase activity
AC614_22525	COG3328	transposase activity
AC614_22590	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)