locus-tag	class	description
DGN16_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DGN16_00025	COG0187	DNA topoisomerase II activity
DGN16_00035	COG0501	Belongs to the peptidase M48B family
DGN16_00075	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DGN16_00085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN16_00135	COG0793	Belongs to the peptidase S41A family
DGN16_00140	COG4942	peptidase
DGN16_00150	COG2234	aminopeptidase activity
DGN16_00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN16_00165	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN16_00175	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN16_00185	COG1064	alcohol dehydrogenase
DGN16_00190	COG0493	'glutamate synthase
DGN16_00195	COG0067	glutamate synthase
DGN16_00195	COG0069	glutamate synthase activity
DGN16_00195	COG0070	glutamate synthase
DGN16_00280	COG1111	helicase
DGN16_00280	COG1205	dead DEAH box helicase
DGN16_00285	COG1272	protein, Hemolysin III
DGN16_00305	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_00310	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_00335	COG2249	NAD(P)H dehydrogenase (quinone) activity
DGN16_00355	COG3039	Transposase
DGN16_00385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DGN16_00400	COG1125	glycine betaine transport
DGN16_00400	COG0517	IMP dehydrogenase activity
DGN16_00415	COG1119	ATPase activity
DGN16_00425	COG1752	Esterase of the alpha-beta hydrolase superfamily
DGN16_00435	COG1522	sequence-specific DNA binding
DGN16_00440	COG3186	Phenylalanine-4-hydroxylase
DGN16_00450	COG2755	lipolytic protein G-D-S-L family
DGN16_00460	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_00465	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DGN16_00480	COG1609	Transcriptional regulator
DGN16_00485	COG3507	Belongs to the glycosyl hydrolase 43 family
DGN16_00500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DGN16_00510	COG0657	acetylesterase activity
DGN16_00510	COG2755	lipolytic protein G-D-S-L family
DGN16_00530	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGN16_00535	COG0366	Alpha amylase catalytic
DGN16_00540	COG0366	Alpha amylase catalytic
DGN16_00565	COG3039	Transposase
DGN16_00590	COG3328	transposase activity
DGN16_00595	COG3328	transposase activity
DGN16_00620	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DGN16_00625	COG3710	Transcriptional regulator
DGN16_00645	COG2197	response regulator
DGN16_00650	COG4585	Histidine kinase
DGN16_00665	COG1304	FMN binding
DGN16_00690	COG1012	belongs to the aldehyde dehydrogenase family
DGN16_00705	COG4772	TonB-dependent receptor
DGN16_00715	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DGN16_00750	COG0714	Associated with various cellular activities
DGN16_00795	COG0477	Major facilitator Superfamily
DGN16_00805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGN16_00830	COG3039	Transposase
DGN16_00860	COG3237	CsbD-like
DGN16_00870	COG3039	Transposase
DGN16_00880	COG0489	protein tyrosine kinase activity
DGN16_00885	COG2062	phosphohistidine phosphatase, SixA
DGN16_00895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN16_00940	COG1968	undecaprenyl-diphosphatase activity
DGN16_00950	COG0174	glutamine synthetase
DGN16_00955	COG0347	Belongs to the P(II) protein family
DGN16_00960	COG0004	ammonium transporteR
DGN16_00965	COG3852	Histidine kinase
DGN16_00970	COG2204	response regulator
DGN16_00975	COG2032	superoxide dismutase activity
DGN16_00980	COG2032	superoxide dismutase activity
DGN16_00990	COG3039	Transposase
DGN16_01005	COG0183	Belongs to the thiolase family
DGN16_01040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DGN16_01045	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DGN16_01050	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DGN16_01065	COG0028	Belongs to the TPP enzyme family
DGN16_01070	COG2205	protein histidine kinase activity
DGN16_01095	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DGN16_01110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN16_01120	COG0596	Alpha beta hydrolase
DGN16_01125	COG0727	PFAM Uncharacterised protein family (UPF0153)
DGN16_01130	COG0318	PFAM AMP-dependent synthetase and ligase
DGN16_01135	COG0745	RESPONSE REGULATOR receiver
DGN16_01145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN16_01175	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DGN16_01185	COG0564	pseudouridine synthase activity
DGN16_01205	COG1446	asparaginase
DGN16_01210	COG0339	signal peptide processing
DGN16_01245	COG0475	glutathione-regulated potassium exporter activity
DGN16_01250	COG0583	DNA-binding transcription factor activity
DGN16_01255	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DGN16_01260	COG2224	Isocitrate lyase
DGN16_01275	COG3039	Transposase
DGN16_01305	COG4770	biotin carboxylase activity
DGN16_01310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DGN16_01315	COG1960	acyl-CoA dehydrogenase activity
DGN16_01380	COG0697	spore germination
DGN16_01390	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DGN16_01395	COG1846	Transcriptional regulator
DGN16_01400	COG1764	response to oxidative stress
DGN16_01430	COG2130	NADP-dependent
DGN16_01445	COG1187	pseudouridine synthase activity
DGN16_01460	COG1643	Atp-dependent helicase
DGN16_01470	COG4807	Protein conserved in bacteria
DGN16_01475	COG2351	hydroxyisourate hydrolase activity
DGN16_01480	COG2072	flavoprotein involved in K transport
DGN16_01500	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DGN16_01510	COG0583	DNA-binding transcription factor activity
DGN16_01545	COG2252	PERMEase
DGN16_01590	COG0583	DNA-binding transcription factor activity
DGN16_01595	COG2814	Major facilitator Superfamily
DGN16_01605	COG2267	carboxylic ester hydrolase activity
DGN16_01610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DGN16_01615	COG1902	pentaerythritol trinitrate reductase activity
DGN16_01635	COG0745	RESPONSE REGULATOR receiver
DGN16_01640	COG2205	protein histidine kinase activity
DGN16_01645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN16_01665	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DGN16_01670	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DGN16_01675	COG0583	DNA-binding transcription factor activity
DGN16_01710	COG0702	epimerase
DGN16_01715	COG1733	regulation of RNA biosynthetic process
DGN16_01755	COG3328	transposase activity
DGN16_01765	COG3039	Transposase
DGN16_01775	COG0129	dihydroxy-acid dehydratase activity
DGN16_01790	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DGN16_01845	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DGN16_01850	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DGN16_01875	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DGN16_01880	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DGN16_01890	COG3485	protocatechuate 3,4-dioxygenase
DGN16_01895	COG3485	protocatechuate 3,4-dioxygenase
DGN16_01905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN16_01910	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DGN16_01925	COG1414	Transcriptional regulator
DGN16_01935	COG0657	acetylesterase activity
DGN16_01945	COG0445	tRNA wobble uridine modification
DGN16_01955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DGN16_01985	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_01990	COG2267	carboxylic ester hydrolase activity
DGN16_02000	COG0156	8-amino-7-oxononanoate synthase activity
DGN16_02005	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DGN16_02010	COG1040	competence protein
DGN16_02020	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DGN16_02055	COG3039	Transposase
DGN16_02125	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DGN16_02215	COG1511	domain protein
DGN16_02215	COG3264	Mechanosensitive ion channel
DGN16_02220	COG1368	sulfuric ester hydrolase activity
DGN16_02225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DGN16_02235	COG2354	Protein conserved in bacteria
DGN16_02245	COG0297	glycogen (starch) synthase activity
DGN16_02250	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGN16_02255	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGN16_02280	COG0702	epimerase
DGN16_02285	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_02320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN16_02325	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_02335	COG0513	Belongs to the DEAD box helicase family
DGN16_02340	COG0508	dehydrogenase complex catalyzes the overall conversion of
DGN16_02355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DGN16_02365	COG3483	tryptophan 2,3-dioxygenase activity
DGN16_02370	COG3104	oligopeptide transport
DGN16_02410	COG1320	monovalent cation:proton antiporter activity
DGN16_02415	COG2212	antiporter activity
DGN16_02425	COG0651	ATP synthesis coupled electron transport
DGN16_02430	COG1006	Multisubunit Na H antiporter MnhC subunit
DGN16_02435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DGN16_02435	COG2111	Na H antiporter
DGN16_02460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DGN16_02465	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DGN16_02480	COG0456	acetyltransferase
DGN16_02485	COG1597	lipid kinase activity
DGN16_02510	COG3039	Transposase
DGN16_02525	COG3039	Transposase
DGN16_02545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DGN16_02550	COG0134	indole-3-glycerol-phosphate synthase activity
DGN16_02560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGN16_02565	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DGN16_02575	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DGN16_02585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DGN16_02600	COG1051	belongs to the nudix hydrolase family
DGN16_02640	COG0316	Belongs to the HesB IscA family
DGN16_02655	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DGN16_02670	COG2814	Major facilitator Superfamily
DGN16_02680	COG2814	Major facilitator Superfamily
DGN16_02685	COG1289	transmembrane transporter activity
DGN16_02695	COG0151	Belongs to the GarS family
DGN16_02705	COG0138	bifunctional purine biosynthesis protein purh
DGN16_02710	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DGN16_02720	COG2453	phosphatase
DGN16_02720	COG0671	phosphoesterase, PA-phosphatase related
DGN16_02745	COG4589	Belongs to the CDS family
DGN16_02750	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DGN16_02775	COG2264	protein methyltransferase activity
DGN16_02795	COG0439	Biotin carboxylase
DGN16_02805	COG0511	ligase activity, forming carbon-carbon bonds
DGN16_02810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DGN16_02820	COG1324	tolerance protein
DGN16_02830	COG2356	endonuclease I
DGN16_02840	COG0459	protein refolding
DGN16_02855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DGN16_02870	COG3386	PFAM SMP-30 Gluconolaconase
DGN16_02880	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DGN16_02885	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DGN16_02910	COG0778	Nitroreductase
DGN16_02915	COG2353	YceI-like domain
DGN16_02945	COG3052	prosthetic group binding
DGN16_02970	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DGN16_02980	COG1802	Transcriptional regulator
DGN16_03045	COG3039	Transposase
DGN16_03070	COG3039	Transposase
DGN16_03110	COG4221	oxidoreductase activity
DGN16_03125	COG4221	oxidoreductase activity
DGN16_03135	COG0435	Glutathione S-transferase
DGN16_03170	COG0823	Involved in the tonB-independent uptake of proteins
DGN16_03170	COG1506	peptidase
DGN16_03215	COG0697	spore germination
DGN16_03220	COG4305	rare lipoprotein A
DGN16_03225	COG5297	Belongs to the glycosyl hydrolase family 6
DGN16_03235	COG1113	amino acid transport
DGN16_03255	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DGN16_03305	COG0840	transmembrane signaling receptor activity
DGN16_03310	COG5297	Belongs to the glycosyl hydrolase family 6
DGN16_03310	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN16_03315	COG0659	secondary active sulfate transmembrane transporter activity
DGN16_03345	COG2943	transferase activity, transferring hexosyl groups
DGN16_03355	COG3275	phosphorelay sensor kinase activity
DGN16_03365	COG0181	hydroxymethylbilane synthase activity
DGN16_03395	COG1505	serine-type exopeptidase activity
DGN16_03400	COG0436	Aminotransferase
DGN16_03410	COG2832	Protein of unknown function (DUF454)
DGN16_03420	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DGN16_03430	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DGN16_03435	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DGN16_03440	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DGN16_03465	COG2226	methyltransferase
DGN16_03470	COG5001	Diguanylate cyclase
DGN16_03470	COG3300	MHYT domain
DGN16_03475	COG0308	aminopeptidase N
DGN16_03530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGN16_03535	COG1077	Cell shape determining protein MreB Mrl
DGN16_03540	COG1792	Involved in formation and maintenance of cell shape
DGN16_03555	COG0772	Belongs to the SEDS family
DGN16_03565	COG2951	lytic endotransglycosylase activity
DGN16_03570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DGN16_03580	COG1686	Belongs to the peptidase S11 family
DGN16_03590	COG2921	Belongs to the UPF0250 family
DGN16_03595	COG0321	lipoyl(octanoyl) transferase activity
DGN16_03600	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DGN16_03625	COG1051	belongs to the nudix hydrolase family
DGN16_03625	COG1056	cytidyltransferase-related domain
DGN16_03660	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DGN16_03665	COG0673	inositol 2-dehydrogenase activity
DGN16_03670	COG2823	Periplasmic or secreted lipoprotein
DGN16_03675	COG4251	negative regulation of phosphorylation
DGN16_03680	COG0784	Response regulator, receiver
DGN16_03685	COG4191	Histidine kinase
DGN16_03690	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DGN16_03750	COG1459	type II secretion system
DGN16_03755	COG2165	general secretion pathway protein
DGN16_03770	COG4795	General secretion pathway protein
DGN16_03800	COG3250	beta-galactosidase activity
DGN16_03815	COG2188	Transcriptional regulator
DGN16_03825	COG1609	Transcriptional regulator
DGN16_03830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DGN16_03835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DGN16_03850	COG0617	tRNA 3'-terminal CCA addition
DGN16_03855	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DGN16_03860	COG1012	belongs to the aldehyde dehydrogenase family
DGN16_03865	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DGN16_03880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DGN16_03895	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DGN16_03920	COG2205	protein histidine kinase activity
DGN16_03950	COG3791	Glutathione-dependent formaldehyde-activating
DGN16_03965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DGN16_03990	COG0488	(ABC) transporter
DGN16_04000	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DGN16_04005	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DGN16_04015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DGN16_04015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DGN16_04035	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DGN16_04040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DGN16_04045	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DGN16_04070	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DGN16_04075	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DGN16_04080	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DGN16_04085	COG2205	protein histidine kinase activity
DGN16_04090	COG0745	RESPONSE REGULATOR receiver
DGN16_04095	COG0277	FAD linked oxidase domain protein
DGN16_04100	COG1988	membrane-bound metal-dependent
DGN16_04105	COG0792	nuclease activity
DGN16_04135	COG0275	rRNA processing
DGN16_04140	COG3116	cell division
DGN16_04150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DGN16_04155	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DGN16_04160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DGN16_04170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DGN16_04175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DGN16_04180	COG1181	Belongs to the D-alanine--D-alanine ligase family
DGN16_04185	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DGN16_04200	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DGN16_04210	COG0739	heme binding
DGN16_04215	COG0653	protein targeting
DGN16_04220	COG0494	nUDIX hydrolase
DGN16_04230	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DGN16_04245	COG3321	synthase
DGN16_04245	COG0604	alcohol dehydrogenase
DGN16_04245	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_04270	COG0366	Alpha amylase catalytic
DGN16_04310	COG2226	methyltransferase
DGN16_04315	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DGN16_04325	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DGN16_04365	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DGN16_04375	COG4106	trans-aconitate 2-methyltransferase activity
DGN16_04380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DGN16_04390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGN16_04395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DGN16_04405	COG0667	Aldo Keto reductase
DGN16_04415	COG4771	TonB-dependent receptor
DGN16_04435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DGN16_04440	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DGN16_04450	COG2175	clavaminate synthase activity
DGN16_04460	COG4181	ATPase activity
DGN16_04475	COG0642	Histidine kinase
DGN16_04485	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DGN16_04505	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DGN16_04510	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DGN16_04525	COG3829	transcription factor binding
DGN16_04535	COG1116	anion transmembrane transporter activity
DGN16_04540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DGN16_04550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DGN16_04555	COG0431	NADPH-dependent FMN reductase
DGN16_04575	COG0747	negative chemotaxis
DGN16_04585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DGN16_04595	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DGN16_04600	COG2967	ApaG domain
DGN16_04605	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DGN16_04610	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DGN16_04615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGN16_04620	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DGN16_04645	COG0123	including yeast histone deacetylase and acetoin utilization protein
DGN16_04650	COG2096	Adenosyltransferase
DGN16_04665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN16_04670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN16_04700	COG3384	dioxygenase
DGN16_04705	COG0583	DNA-binding transcription factor activity
DGN16_04720	COG1024	Enoyl-CoA hydratase
DGN16_04750	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DGN16_04775	COG0697	spore germination
DGN16_04785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGN16_04815	COG2197	response regulator
DGN16_04825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DGN16_04835	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DGN16_04840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGN16_04850	COG0583	DNA-binding transcription factor activity
DGN16_04855	COG3634	alkyl hydroperoxide reductase activity
DGN16_04865	COG2890	protein-(glutamine-N5) methyltransferase activity
DGN16_04885	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DGN16_04885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DGN16_04905	COG3039	Transposase
DGN16_04920	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DGN16_04965	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DGN16_04970	COG1404	Belongs to the peptidase S8 family
DGN16_04975	COG1404	Belongs to the peptidase S8 family
DGN16_04980	COG1404	Belongs to the peptidase S8 family
DGN16_04985	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DGN16_05010	COG1295	ribonuclease BN
DGN16_05015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGN16_05020	COG1254	Belongs to the acylphosphatase family
DGN16_05035	COG0521	Mo-molybdopterin cofactor biosynthetic process
DGN16_05045	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DGN16_05050	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DGN16_05060	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DGN16_05065	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DGN16_05075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DGN16_05080	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DGN16_05085	COG0193	aminoacyl-tRNA hydrolase activity
DGN16_05090	COG0012	GTP binding
DGN16_05110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DGN16_05125	COG0250	Participates in transcription elongation, termination and antitermination
DGN16_05130	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DGN16_05135	COG0081	regulation of translation
DGN16_05140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DGN16_05145	COG0222	ribosome binding
DGN16_05150	COG0085	RNA polymerase activity
DGN16_05155	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DGN16_05160	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DGN16_05165	COG0049	tRNA binding
DGN16_05170	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DGN16_05175	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DGN16_05180	COG0051	transcription antitermination factor activity, RNA binding
DGN16_05185	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DGN16_05190	COG0088	Forms part of the polypeptide exit tunnel
DGN16_05195	COG0089	rRNA binding
DGN16_05200	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DGN16_05205	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DGN16_05215	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DGN16_05220	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DGN16_05225	COG0255	Belongs to the universal ribosomal protein uL29 family
DGN16_05230	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DGN16_05240	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DGN16_05245	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DGN16_05255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DGN16_05260	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DGN16_05265	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DGN16_05275	COG1841	ribosomal large subunit assembly
DGN16_05280	COG0200	Binds to the 23S rRNA
DGN16_05285	COG0201	protein transport
DGN16_05310	COG0203	ribosomal protein L17
DGN16_05315	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DGN16_05335	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DGN16_05350	COG0154	amidase activity
DGN16_05360	COG1217	gtp-binding protein TYPA
DGN16_05365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DGN16_05370	COG0039	L-malate dehydrogenase activity
DGN16_05375	COG0625	glutathione transferase activity
DGN16_05390	COG1902	pentaerythritol trinitrate reductase activity
DGN16_05390	COG0446	pyridine nucleotide-disulphide oxidoreductase
DGN16_05395	COG0604	alcohol dehydrogenase
DGN16_05425	COG0156	8-amino-7-oxononanoate synthase activity
DGN16_05435	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DGN16_05440	COG4208	sulfate ABC transporter
DGN16_05445	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DGN16_05475	COG0406	alpha-ribazole phosphatase activity
DGN16_05480	COG0285	dihydrofolate synthase activity
DGN16_05500	COG2833	Protein of unknown function (DUF455)
DGN16_05520	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN16_05525	COG0671	phosphoesterase, PA-phosphatase related
DGN16_05530	COG0438	transferase activity, transferring glycosyl groups
DGN16_05540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DGN16_05555	COG4783	chaperone-mediated protein folding
DGN16_05570	COG0473	3-isopropylmalate dehydrogenase activity
DGN16_05610	COG0544	peptidyl-prolyl cis-trans isomerase activity
DGN16_05620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DGN16_05650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGN16_05665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGN16_05675	COG0328	RNA-DNA hybrid ribonuclease activity
DGN16_05680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DGN16_05685	COG0631	protein serine/threonine phosphatase activity
DGN16_05700	COG0859	PFAM glycosyl transferase family 9
DGN16_05705	COG3642	lipopolysaccharide core region biosynthetic process
DGN16_05710	COG1234	tRNA 3'-trailer cleavage
DGN16_05715	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DGN16_05725	COG0315	cyclic pyranopterin monophosphate synthase activity
DGN16_05730	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DGN16_05735	COG0314	molybdopterin synthase activity
DGN16_05765	COG3039	Transposase
DGN16_05780	COG3328	transposase activity
DGN16_05800	COG3039	Transposase
DGN16_05840	COG3328	transposase activity
DGN16_05860	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DGN16_05865	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DGN16_05870	COG0537	adenosine 5'-monophosphoramidase activity
DGN16_05890	COG0714	Associated with various cellular activities
DGN16_05915	COG0424	maF-like protein
DGN16_05920	COG1399	metal-binding, possibly nucleic acid-binding protein
DGN16_05930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN16_05940	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DGN16_05945	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_05960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DGN16_05965	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DGN16_05990	COG3829	transcription factor binding
DGN16_06035	COG2373	Large extracellular alpha-helical protein
DGN16_06055	COG4953	penicillin-binding protein 1C
DGN16_06065	COG0678	peroxiredoxin activity
DGN16_06085	COG0330	HflC and HflK could
DGN16_06090	COG0330	HflC and HflK could
DGN16_06100	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DGN16_06110	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_06115	COG1309	transcriptional regulator
DGN16_06160	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DGN16_06165	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
DGN16_06175	COG3039	Transposase
DGN16_06180	COG0732	type I restriction modification DNA specificity domain
DGN16_06195	COG3039	Transposase
DGN16_06205	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DGN16_06240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DGN16_06250	COG3039	Transposase
DGN16_06260	COG3387	PFAM Glycoside hydrolase 15-related
DGN16_06270	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_06280	COG3537	Alpha-1,2-mannosidase
DGN16_06285	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_06300	COG0492	ferredoxin-NADP+ reductase activity
DGN16_06335	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DGN16_06340	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DGN16_06345	COG2080	2 iron, 2 sulfur cluster binding
DGN16_06380	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DGN16_06395	COG0587	DNA-directed DNA polymerase activity
DGN16_06410	COG1297	OPT oligopeptide transporter protein
DGN16_06425	COG1506	peptidase
DGN16_06425	COG0823	Involved in the tonB-independent uptake of proteins
DGN16_06440	COG1917	Cupin 2, conserved barrel domain protein
DGN16_06440	COG2207	Transcriptional regulator
DGN16_06470	COG0753	catalase activity
DGN16_06475	COG0656	L-ascorbic acid biosynthetic process
DGN16_06485	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DGN16_06485	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DGN16_06490	COG2814	Major facilitator Superfamily
DGN16_06505	COG2194	sulfuric ester hydrolase activity
DGN16_06520	COG0745	RESPONSE REGULATOR receiver
DGN16_06525	COG0642	Histidine kinase
DGN16_06535	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DGN16_06540	COG2894	cell division
DGN16_06545	COG0850	regulation of cytokinetic process
DGN16_06560	COG4585	Histidine kinase
DGN16_06565	COG2197	response regulator
DGN16_06580	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DGN16_06610	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DGN16_06620	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DGN16_06640	COG1946	Acyl-CoA thioesterase
DGN16_06655	COG0824	Thioesterase
DGN16_06660	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DGN16_06665	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DGN16_06670	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DGN16_06675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DGN16_06680	COG0268	Binds directly to 16S ribosomal RNA
DGN16_06690	COG0196	riboflavin kinase activity
DGN16_06695	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DGN16_06700	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DGN16_06705	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DGN16_06740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DGN16_06745	COG1845	cytochrome c oxidase, subunit III
DGN16_06750	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DGN16_06765	COG3328	transposase activity
DGN16_06770	COG3152	Membrane
DGN16_06780	COG2207	Transcriptional regulator
DGN16_06785	COG0326	Molecular chaperone. Has ATPase activity
DGN16_06795	COG1366	Belongs to the anti-sigma-factor antagonist family
DGN16_06800	COG1366	Belongs to the anti-sigma-factor antagonist family
DGN16_06805	COG2172	sigma factor antagonist activity
DGN16_06830	COG4771	TonB-dependent receptor
DGN16_06840	COG5507	3-demethylubiquinone-9 3-methyltransferase
DGN16_06850	COG2205	protein histidine kinase activity
DGN16_06860	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DGN16_06865	COG2205	protein histidine kinase activity
DGN16_06865	COG3437	response regulator, receiver
DGN16_06865	COG3850	Histidine kinase
DGN16_06865	COG4999	Histidine kinase
DGN16_06870	COG4191	Histidine kinase
DGN16_06870	COG0784	Response regulator, receiver
DGN16_06895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DGN16_06900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DGN16_06915	COG0228	four-way junction DNA binding
DGN16_06920	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DGN16_06925	COG0336	Belongs to the RNA methyltransferase TrmD family
DGN16_06930	COG0335	large ribosomal subunit rRNA binding
DGN16_06935	COG0534	Mate efflux family protein
DGN16_06960	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DGN16_06970	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DGN16_06975	COG3328	transposase activity
DGN16_07000	COG3250	beta-galactosidase activity
DGN16_07005	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DGN16_07025	COG1960	acyl-CoA dehydrogenase activity
DGN16_07030	COG1024	Enoyl-CoA hydratase
DGN16_07055	COG3039	Transposase
DGN16_07060	COG3039	Transposase
DGN16_07065	COG3039	Transposase
DGN16_07080	COG3039	Transposase
DGN16_07085	COG1024	Enoyl-CoA hydratase
DGN16_07085	COG1250	3-hydroxyacyl-CoA dehydrogenase
DGN16_07100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DGN16_07105	COG0481	GTPase activity
DGN16_07120	COG0571	ribonuclease III activity
DGN16_07125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DGN16_07130	COG1381	Involved in DNA repair and RecF pathway recombination
DGN16_07140	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DGN16_07145	COG2954	triphosphatase activity
DGN16_07150	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DGN16_07155	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
DGN16_07160	COG3046	protein related to deoxyribodipyrimidine photolyase
DGN16_07165	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN16_07170	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DGN16_07175	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DGN16_07180	COG1278	Cold shock
DGN16_07185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN16_07195	COG1201	RNA secondary structure unwinding
DGN16_07200	COG1793	dna ligase
DGN16_07210	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DGN16_07210	COG1793	dna ligase
DGN16_07240	COG0183	Belongs to the thiolase family
DGN16_07265	COG1451	nucleotide metabolic process
DGN16_07270	COG5487	UPF0391 membrane protein
DGN16_07280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DGN16_07295	COG1077	Cell shape determining protein MreB Mrl
DGN16_07300	COG1047	Peptidyl-prolyl cis-trans
DGN16_07310	COG2824	Alkylphosphonate utilization operon protein PhnA
DGN16_07320	COG1902	pentaerythritol trinitrate reductase activity
DGN16_07325	COG2814	Major facilitator Superfamily
DGN16_07360	COG0392	lysyltransferase activity
DGN16_07360	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DGN16_07370	COG0251	oxidation-reduction process
DGN16_07375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DGN16_07390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DGN16_07415	COG1595	DNA-templated transcription, initiation
DGN16_07440	COG2878	Part of a membrane complex involved in electron transport
DGN16_07450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGN16_07450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGN16_07465	COG3039	Transposase
DGN16_07475	COG1131	(ABC) transporter
DGN16_07480	COG0346	lactoylglutathione lyase activity
DGN16_07485	COG0833	amino acid
DGN16_07490	COG2040	homocysteine
DGN16_07500	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DGN16_07530	COG1695	Transcriptional regulator
DGN16_07550	COG1981	membrane
DGN16_07565	COG0825	malonyl-CoA metabolic process
DGN16_07580	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN16_07585	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN16_07590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DGN16_07595	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN16_07610	COG0750	zinc metalloprotease
DGN16_07615	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DGN16_07620	COG0575	Belongs to the CDS family
DGN16_07625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DGN16_07630	COG0233	cytoplasmic translational termination
DGN16_07635	COG0528	UMP kinase activity
DGN16_07645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DGN16_07650	COG0052	Belongs to the universal ribosomal protein uS2 family
DGN16_07690	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DGN16_07700	COG1393	Belongs to the ArsC family
DGN16_07705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DGN16_07710	COG0367	asparagine synthase
DGN16_07720	COG4774	siderophore transport
DGN16_07735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DGN16_07760	COG1566	PFAM secretion protein HlyD family protein
DGN16_07765	COG2814	Major facilitator Superfamily
DGN16_07815	COG0339	signal peptide processing
DGN16_07825	COG0386	Belongs to the glutathione peroxidase family
DGN16_07880	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DGN16_07885	COG0084	hydrolase, TatD family'
DGN16_07900	COG1960	acyl-CoA dehydrogenase activity
DGN16_07920	COG0367	asparagine synthase
DGN16_07930	COG0305	Participates in initiation and elongation during chromosome replication
DGN16_07935	COG0415	Belongs to the DNA photolyase family
DGN16_07945	COG0583	DNA-binding transcription factor activity
DGN16_07990	COG3706	GGDEF domain
DGN16_08020	COG3328	transposase activity
DGN16_08025	COG0582	viral genome integration into host DNA
DGN16_08040	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DGN16_08055	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN16_08065	COG0497	DNA recombination
DGN16_08070	COG1420	regulation of RNA biosynthetic process
DGN16_08075	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DGN16_08080	COG0443	Heat shock 70 kDa protein
DGN16_08085	COG0484	heat shock protein binding
DGN16_08095	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DGN16_08125	COG0583	DNA-binding transcription factor activity
DGN16_08130	COG1132	(ABC) transporter
DGN16_08155	COG0567	Dehydrogenase, E1 component
DGN16_08165	COG2850	peptidyl-arginine hydroxylation
DGN16_08190	COG1253	flavin adenine dinucleotide binding
DGN16_08225	COG1131	(ABC) transporter
DGN16_08230	COG1725	Transcriptional regulator
DGN16_08240	COG0386	Belongs to the glutathione peroxidase family
DGN16_08255	COG2900	Belongs to the SlyX family
DGN16_08280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGN16_08290	COG0646	methionine synthase
DGN16_08290	COG1410	methionine synthase
DGN16_08295	COG1410	methionine synthase
DGN16_08295	COG0646	methionine synthase
DGN16_08300	COG2226	methyltransferase
DGN16_08305	COG1960	acyl-CoA dehydrogenase activity
DGN16_08315	COG1960	acyl-CoA dehydrogenase activity
DGN16_08335	COG0557	exoribonuclease II activity
DGN16_08345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DGN16_08355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DGN16_08365	COG0704	Plays a role in the regulation of phosphate uptake
DGN16_08370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DGN16_08375	COG0581	inorganic phosphate transmembrane transporter activity
DGN16_08380	COG0573	inorganic phosphate transmembrane transporter activity
DGN16_08385	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DGN16_08410	COG0659	secondary active sulfate transmembrane transporter activity
DGN16_08415	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DGN16_08425	COG1024	Enoyl-CoA hydratase
DGN16_08435	COG0494	nUDIX hydrolase
DGN16_08470	COG0488	(ABC) transporter
DGN16_08480	COG0116	Belongs to the methyltransferase superfamily
DGN16_08480	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DGN16_08485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DGN16_08510	COG2925	Exonuclease
DGN16_08515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN16_08520	COG3844	kynureninase activity
DGN16_08530	COG0662	Cupin 2, conserved barrel domain protein
DGN16_08535	COG0288	reversible hydration of carbon dioxide
DGN16_08585	COG3039	Transposase
DGN16_08620	COG0017	Asparaginyl-tRNA synthetase
DGN16_08630	COG0316	Belongs to the HesB IscA family
DGN16_08635	COG0360	Binds together with S18 to 16S ribosomal RNA
DGN16_08640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DGN16_08645	COG0359	binds to the 23S rRNA
DGN16_08660	COG3115	cell septum assembly
DGN16_08670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGN16_08675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DGN16_08680	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DGN16_08695	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DGN16_08705	COG4993	Dehydrogenase
DGN16_08715	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DGN16_08725	COG2986	histidine ammonia-lyase
DGN16_08730	COG1228	amidohydrolase
DGN16_08770	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DGN16_08775	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DGN16_08780	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DGN16_08785	COG0077	Prephenate dehydratase
DGN16_08785	COG1605	Chorismate mutase
DGN16_08790	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DGN16_08810	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DGN16_08815	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DGN16_08820	COG0583	DNA-binding transcription factor activity
DGN16_08840	COG3328	transposase activity
DGN16_08875	COG0840	transmembrane signaling receptor activity
DGN16_08910	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DGN16_08915	COG4191	Histidine kinase
DGN16_08915	COG0784	Response regulator, receiver
DGN16_08930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGN16_08940	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DGN16_08950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DGN16_08965	COG1595	DNA-templated transcription, initiation
DGN16_09020	COG2244	polysaccharide biosynthetic process
DGN16_09050	COG2264	protein methyltransferase activity
DGN16_09060	COG0438	transferase activity, transferring glycosyl groups
DGN16_09075	COG1136	(ABC) transporter
DGN16_09085	COG2271	Major facilitator Superfamily
DGN16_09095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DGN16_09105	COG1253	flavin adenine dinucleotide binding
DGN16_09120	COG0306	phosphate transporter
DGN16_09150	COG0504	CTP synthase activity
DGN16_09165	COG0148	phosphopyruvate hydratase activity
DGN16_09170	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DGN16_09175	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DGN16_09180	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DGN16_09185	COG0585	pseudouridine synthase activity
DGN16_09190	COG2840	Smr protein MutS2
DGN16_09195	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DGN16_09200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DGN16_09205	COG1238	metal cluster binding
DGN16_09220	COG1534	Rna-binding protein
DGN16_09225	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DGN16_09235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DGN16_09240	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DGN16_09250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DGN16_09255	COG1546	Belongs to the CinA family
DGN16_09265	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DGN16_09270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DGN16_09280	COG2137	regulation of response to DNA damage stimulus
DGN16_09285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DGN16_09290	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DGN16_09310	COG1741	Belongs to the pirin family
DGN16_09315	COG0583	DNA-binding transcription factor activity
DGN16_09340	COG0351	phosphomethylpyrimidine kinase
DGN16_09355	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DGN16_09360	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DGN16_09375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DGN16_09385	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DGN16_09390	COG3734	2-keto-3-deoxy-galactonokinase
DGN16_09400	COG4948	Mandelate Racemase Muconate Lactonizing
DGN16_09405	COG0800	Aldolase
DGN16_09445	COG1501	Belongs to the glycosyl hydrolase 31 family
DGN16_09455	COG1070	Carbohydrate kinase
DGN16_09465	COG3328	transposase activity
DGN16_09480	COG3328	transposase activity
DGN16_09515	COG3039	Transposase
DGN16_09525	COG0860	N-Acetylmuramoyl-L-alanine amidase
DGN16_09530	COG1469	GTP cyclohydrolase I activity
DGN16_09550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DGN16_09555	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DGN16_09560	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DGN16_09590	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN16_09605	COG4251	negative regulation of phosphorylation
DGN16_09605	COG3706	GGDEF domain
DGN16_09605	COG5001	Diguanylate cyclase
DGN16_09605	COG2203	Gaf domain
DGN16_09610	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN16_09615	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DGN16_09625	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DGN16_09645	COG1794	racemase activity, acting on amino acids and derivatives
DGN16_09655	COG0697	spore germination
DGN16_09660	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DGN16_09665	COG0167	dihydroorotate dehydrogenase activity
DGN16_09680	COG1012	belongs to the aldehyde dehydrogenase family
DGN16_09695	COG1215	transferase activity, transferring glycosyl groups
DGN16_09700	COG0726	polysaccharide deacetylase
DGN16_09700	COG1649	PFAM Uncharacterised BCR, COG1649
DGN16_09775	COG3328	transposase activity
DGN16_09815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGN16_09820	COG0124	histidyl-tRNA synthetase
DGN16_09830	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DGN16_09835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DGN16_09840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGN16_09845	COG0131	Imidazoleglycerol-phosphate dehydratase
DGN16_09845	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DGN16_09850	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DGN16_09855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DGN16_09860	COG0107	imidazoleglycerol-phosphate synthase activity
DGN16_09865	COG0140	phosphoribosyl-ATP diphosphatase activity
DGN16_09865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DGN16_09880	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
DGN16_09885	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DGN16_09890	COG0235	Class ii aldolase
DGN16_09895	COG0531	amino acid
DGN16_09900	COG0531	amino acid
DGN16_09910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DGN16_09915	COG0277	FAD linked oxidase domain protein
DGN16_09935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DGN16_09980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DGN16_09985	COG2258	MOSC domain
DGN16_09990	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DGN16_09995	COG0505	Belongs to the CarA family
DGN16_10005	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DGN16_10010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGN16_10020	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DGN16_10030	COG3279	Response regulator of the LytR AlgR family
DGN16_10050	COG2198	Histidine kinase
DGN16_10050	COG0784	Response regulator, receiver
DGN16_10050	COG2205	protein histidine kinase activity
DGN16_10055	COG2205	protein histidine kinase activity
DGN16_10055	COG2198	Histidine kinase
DGN16_10055	COG0784	Response regulator, receiver
DGN16_10060	COG1024	Enoyl-CoA hydratase
DGN16_10065	COG0318	PFAM AMP-dependent synthetase and ligase
DGN16_10095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN16_10105	COG2201	protein-glutamate methylesterase activity
DGN16_10110	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DGN16_10120	COG0840	transmembrane signaling receptor activity
DGN16_10135	COG0835	chemotaxis
DGN16_10165	COG0840	transmembrane signaling receptor activity
DGN16_10170	COG0840	transmembrane signaling receptor activity
DGN16_10175	COG0840	transmembrane signaling receptor activity
DGN16_10180	COG0840	transmembrane signaling receptor activity
DGN16_10190	COG0840	transmembrane signaling receptor activity
DGN16_10200	COG0840	transmembrane signaling receptor activity
DGN16_10205	COG0840	transmembrane signaling receptor activity
DGN16_10225	COG0840	transmembrane signaling receptor activity
DGN16_10235	COG0745	RESPONSE REGULATOR receiver
DGN16_10245	COG0835	chemotaxis
DGN16_10255	COG1360	Flagellar Motor Protein
DGN16_10260	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DGN16_10275	COG3039	Transposase
DGN16_10305	COG3039	Transposase
DGN16_10335	COG0643	Histidine kinase
DGN16_10335	COG0784	Response regulator, receiver
DGN16_10335	COG2198	Histidine kinase
DGN16_10370	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DGN16_10400	COG1684	flagellar biosynthetic protein fliR
DGN16_10420	COG3190	flagellar
DGN16_10470	COG1677	Flagellar hook-basal body complex protein FliE
DGN16_10485	COG3039	Transposase
DGN16_10515	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_10520	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_10525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN16_10545	COG2201	protein-glutamate methylesterase activity
DGN16_10575	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DGN16_10590	COG3039	Transposase
DGN16_10595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DGN16_10605	COG1705	Flagellar rod assembly protein muramidase FlgJ
DGN16_10605	COG3951	Flagellar rod assembly protein muramidase FlgJ
DGN16_10610	COG1706	bacterial-type flagellum-dependent cell motility
DGN16_10615	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DGN16_10625	COG4787	bacterial-type flagellum-dependent cell motility
DGN16_10635	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DGN16_10640	COG1558	bacterial-type flagellum-dependent cell motility
DGN16_10650	COG0784	Response regulator, receiver
DGN16_10650	COG0835	chemotaxis
DGN16_10670	COG5002	protein histidine kinase activity
DGN16_10700	COG2915	High frequency lysogenization protein hflD homolog
DGN16_10705	COG0482	sulfurtransferase activity
DGN16_10720	COG0542	response to heat
DGN16_10730	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DGN16_10740	COG0492	ferredoxin-NADP+ reductase activity
DGN16_10745	COG1674	ftsk spoiiie
DGN16_10755	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DGN16_10765	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DGN16_10770	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DGN16_10780	COG0183	Belongs to the thiolase family
DGN16_10785	COG1024	Enoyl-CoA hydratase
DGN16_10785	COG1250	3-hydroxyacyl-CoA dehydrogenase
DGN16_10800	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DGN16_10810	COG1426	Protein conserved in bacteria
DGN16_10820	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN16_10825	COG1160	GTP binding
DGN16_10830	COG0303	'Molybdopterin
DGN16_10835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DGN16_10870	COG0708	Exodeoxyribonuclease III
DGN16_10880	COG0303	'Molybdopterin
DGN16_10885	COG0746	molybdenum cofactor guanylyltransferase activity
DGN16_10915	COG1914	H( )-stimulated, divalent metal cation uptake system
DGN16_10930	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DGN16_10935	COG0668	transmembrane transport
DGN16_10945	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DGN16_10960	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_10965	COG1183	phosphatidylcholine synthase activity
DGN16_10975	COG3243	poly(R)-hydroxyalkanoic acid synthase
DGN16_10990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN16_10990	COG0723	plastoquinol--plastocyanin reductase activity
DGN16_11000	COG2183	response to ionizing radiation
DGN16_11005	COG2205	protein histidine kinase activity
DGN16_11005	COG0784	Response regulator, receiver
DGN16_11075	COG0800	Aldolase
DGN16_11080	COG0129	dihydroxy-acid dehydratase activity
DGN16_11085	COG0363	glucosamine-6-phosphate deaminase activity
DGN16_11090	COG0837	glucose binding
DGN16_11095	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DGN16_11105	COG0354	folic acid binding
DGN16_11120	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DGN16_11135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DGN16_11140	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DGN16_11150	COG4591	ABC-type transport system involved in lipoprotein release permease component
DGN16_11155	COG1136	(ABC) transporter
DGN16_11170	COG0811	peptide transport
DGN16_11175	COG0848	biopolymer transport protein
DGN16_11180	COG1132	(ABC) transporter
DGN16_11185	COG1663	tetraacyldisaccharide 4'-kinase activity
DGN16_11190	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DGN16_11195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DGN16_11205	COG0322	excinuclease ABC activity
DGN16_11210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DGN16_11240	COG0582	viral genome integration into host DNA
DGN16_11250	COG3328	transposase activity
DGN16_11270	COG3328	transposase activity
DGN16_11280	COG0366	Alpha amylase catalytic
DGN16_11290	COG3039	Transposase
DGN16_11325	COG3039	Transposase
DGN16_11360	COG2211	Major facilitator Superfamily
DGN16_11360	COG2190	(PTS) system
DGN16_11375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DGN16_11380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DGN16_11395	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DGN16_11400	COG0072	phenylalanine-tRNA ligase activity
DGN16_11400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGN16_11450	COG0438	transferase activity, transferring glycosyl groups
DGN16_11455	COG0438	transferase activity, transferring glycosyl groups
DGN16_11465	COG0438	transferase activity, transferring glycosyl groups
DGN16_11490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN16_11495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGN16_11500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN16_11520	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DGN16_11530	COG1960	acyl-CoA dehydrogenase activity
DGN16_11540	COG3040	lipid binding
DGN16_11550	COG0582	viral genome integration into host DNA
DGN16_11560	COG3039	Transposase
DGN16_11570	COG3039	Transposase
DGN16_11585	COG3039	Transposase
DGN16_11620	COG0784	Response regulator, receiver
DGN16_11620	COG4191	Histidine kinase
DGN16_11625	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
DGN16_11630	COG1194	a g-specific adenine glycosylase
DGN16_11640	COG0552	protein localization to endoplasmic reticulum
DGN16_11650	COG3938	Belongs to the proline racemase family
DGN16_11655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN16_11670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DGN16_11680	COG0006	proline dipeptidase activity
DGN16_11695	COG0531	amino acid
DGN16_11785	COG3039	Transposase
DGN16_11795	COG0326	Molecular chaperone. Has ATPase activity
DGN16_11800	COG0742	ribosomal rna small subunit methyltransferase
DGN16_11805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DGN16_11820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DGN16_11825	COG0405	Gamma-glutamyltransferase
DGN16_11830	COG3291	Pkd domain containing protein
DGN16_11835	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DGN16_11880	COG0343	queuine tRNA-ribosyltransferase activity
DGN16_11885	COG1862	Preprotein translocase
DGN16_11895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DGN16_11965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DGN16_11965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DGN16_11970	COG1105	Belongs to the carbohydrate kinase PfkB family
DGN16_11975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DGN16_11975	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGN16_11980	COG1609	Transcriptional regulator
DGN16_11985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN16_11990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN16_12000	COG2902	Dehydrogenase
DGN16_12010	COG3321	synthase
DGN16_12010	COG0604	alcohol dehydrogenase
DGN16_12020	COG1902	pentaerythritol trinitrate reductase activity
DGN16_12030	COG0300	oxidoreductase activity
DGN16_12055	COG0477	Major facilitator Superfamily
DGN16_12070	COG0784	Response regulator, receiver
DGN16_12070	COG5002	protein histidine kinase activity
DGN16_12070	COG2205	protein histidine kinase activity
DGN16_12075	COG2733	membrane
DGN16_12085	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DGN16_12100	COG2223	nitrite transmembrane transporter activity
DGN16_12105	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DGN16_12110	COG0243	molybdopterin cofactor binding
DGN16_12125	COG0477	Major facilitator Superfamily
DGN16_12130	COG2703	oxygen carrier activity
DGN16_12140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN16_12145	COG0174	glutamine synthetase
DGN16_12150	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DGN16_12165	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DGN16_12195	COG1176	ABC-type spermidine putrescine transport system, permease component I
DGN16_12200	COG1177	transmembrane transport
DGN16_12205	COG1012	belongs to the aldehyde dehydrogenase family
DGN16_12220	COG4535	Mg2 and Co2 transporter CorC
DGN16_12230	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DGN16_12240	COG1702	phosphate starvation-inducible protein PhoH
DGN16_12245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DGN16_12260	COG0741	lytic transglycosylase activity
DGN16_12270	COG0723	plastoquinol--plastocyanin reductase activity
DGN16_12275	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DGN16_12280	COG2857	Cytochrome c1
DGN16_12285	COG0625	glutathione transferase activity
DGN16_12290	COG2969	positive regulation of protein catabolic process
DGN16_12310	COG1201	RNA secondary structure unwinding
DGN16_12315	COG2094	Belongs to the DNA glycosylase MPG family
DGN16_12320	COG0840	transmembrane signaling receptor activity
DGN16_12325	COG0835	chemotaxis
DGN16_12370	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DGN16_12385	COG1570	exodeoxyribonuclease VII activity
DGN16_12390	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DGN16_12395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DGN16_12395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DGN16_12400	COG0802	atpase or kinase
DGN16_12405	COG0860	N-Acetylmuramoyl-L-alanine amidase
DGN16_12410	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DGN16_12435	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_12440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGN16_12445	COG0501	Belongs to the peptidase M48B family
DGN16_12450	COG3039	Transposase
DGN16_12460	COG2081	HI0933 family
DGN16_12465	COG4681	YaeQ
DGN16_12475	COG0625	glutathione transferase activity
DGN16_12485	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DGN16_12490	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DGN16_12495	COG0513	Belongs to the DEAD box helicase family
DGN16_12500	COG0488	(ABC) transporter
DGN16_12520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DGN16_12525	COG0483	inositol monophosphate 1-phosphatase activity
DGN16_12540	COG3300	MHYT domain
DGN16_12540	COG5001	Diguanylate cyclase
DGN16_12545	COG1509	lysine 2,3-aminomutase activity
DGN16_12550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DGN16_12560	COG0402	S-adenosylhomocysteine deaminase activity
DGN16_12565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DGN16_12630	COG4302	ethanolamine ammonia-lyase activity
DGN16_12650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DGN16_12655	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DGN16_12670	COG2166	iron-sulfur cluster assembly
DGN16_12675	COG0215	cysteine-tRNA ligase activity
DGN16_12685	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DGN16_12690	COG0137	argininosuccinate synthase activity
DGN16_12700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DGN16_12705	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DGN16_12715	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DGN16_12720	COG0165	Argininosuccinate lyase
DGN16_12730	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DGN16_12735	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DGN16_12770	COG1388	LysM domain
DGN16_12770	COG4942	peptidase
DGN16_12805	COG3328	transposase activity
DGN16_12825	COG1294	oxidase, subunit
DGN16_12835	COG4988	ABC transporter
DGN16_12840	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DGN16_12845	COG1278	Cold shock
DGN16_12850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN16_12870	COG1138	Cytochrome C-type biogenesis protein
DGN16_12875	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DGN16_12895	COG4133	protoheme IX ABC transporter activity
DGN16_12900	COG0436	Aminotransferase
DGN16_12925	COG1187	pseudouridine synthase activity
DGN16_12930	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DGN16_12935	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DGN16_12940	COG2350	Protein conserved in bacteria
DGN16_12970	COG1175	transmembrane transport
DGN16_12975	COG0395	ABC-type sugar transport system, permease component
DGN16_13000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGN16_13005	COG2957	Belongs to the agmatine deiminase family
DGN16_13025	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DGN16_13030	COG0539	negative regulation of cytoplasmic translation
DGN16_13035	COG0776	regulation of translation
DGN16_13045	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DGN16_13050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DGN16_13060	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DGN16_13070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DGN16_13070	COG0475	glutathione-regulated potassium exporter activity
DGN16_13085	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DGN16_13095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DGN16_13095	COG0519	Catalyzes the synthesis of GMP from XMP
DGN16_13105	COG3328	transposase activity
DGN16_13115	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DGN16_13135	COG2197	response regulator
DGN16_13150	COG1335	isochorismatase
DGN16_13180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DGN16_13180	COG1648	precorrin-2 dehydrogenase activity
DGN16_13200	COG3685	Protein conserved in bacteria
DGN16_13220	COG5001	Diguanylate cyclase
DGN16_13230	COG4566	intracellular signal transduction
DGN16_13270	COG3275	phosphorelay sensor kinase activity
DGN16_13275	COG3279	Response regulator of the LytR AlgR family
DGN16_13315	COG4191	Histidine kinase
DGN16_13325	COG3920	Histidine kinase
DGN16_13355	COG3220	belongs to the UPF0276 family
DGN16_13395	COG0583	DNA-binding transcription factor activity
DGN16_13405	COG3039	Transposase
DGN16_13435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN16_13445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN16_13445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGN16_13445	COG3321	synthase
DGN16_13445	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_13445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN16_13445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN16_13445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN16_13445	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_13445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGN16_13445	COG3321	synthase
DGN16_13450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN16_13450	COG3321	synthase
DGN16_13450	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_13450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGN16_13450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN16_13455	COG4221	oxidoreductase activity
DGN16_13455	COG3321	synthase
DGN16_13455	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_13455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN16_13460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DGN16_13465	COG1136	(ABC) transporter
DGN16_13555	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_13560	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DGN16_13565	COG2226	methyltransferase
DGN16_13565	COG1073	alpha beta
DGN16_13615	COG0316	Belongs to the HesB IscA family
DGN16_13615	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DGN16_13620	COG2154	pterin-4-alpha-carbinolamine dehydratase
DGN16_13630	COG0428	transporter
DGN16_13635	COG3064	Membrane
DGN16_13645	COG1530	ribonuclease E activity
DGN16_13655	COG1054	Belongs to the UPF0176 family
DGN16_13675	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DGN16_13755	COG3702	type iv secretory pathway
DGN16_13775	COG2948	multi-organism process
DGN16_13795	COG3505	Type IV secretory pathway VirD4
DGN16_13810	COG0556	nucleotide-excision repair
DGN16_13820	COG3328	transposase activity
DGN16_13880	COG1611	Belongs to the LOG family
DGN16_13895	COG2095	MarC family integral membrane protein
DGN16_13905	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DGN16_13940	COG1185	polyribonucleotide nucleotidyltransferase activity
DGN16_13945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DGN16_13950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DGN16_13955	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DGN16_13960	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DGN16_13965	COG0195	Participates in both transcription termination and antitermination
DGN16_13970	COG0779	Required for maturation of 30S ribosomal subunits
DGN16_13980	COG1007	ATP synthesis coupled electron transport
DGN16_14005	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGN16_14010	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DGN16_14020	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DGN16_14025	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DGN16_14030	COG0649	NAD binding
DGN16_14035	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGN16_14040	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGN16_14045	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGN16_14060	COG0149	triose-phosphate isomerase activity
DGN16_14065	COG0300	oxidoreductase activity
DGN16_14095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DGN16_14100	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DGN16_14105	COG0159	tryptophan synthase activity
DGN16_14115	COG0133	tryptophan synthase activity
DGN16_14125	COG0135	phosphoribosylanthranilate isomerase activity
DGN16_14130	COG0101	tRNA pseudouridine synthase activity
DGN16_14145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DGN16_14150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DGN16_14155	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DGN16_14160	COG2890	protein-(glutamine-N5) methyltransferase activity
DGN16_14170	COG0688	phosphatidylethanolamine metabolic process
DGN16_14185	COG0433	COG0433 Predicted ATPase
DGN16_14190	COG0494	nUDIX hydrolase
DGN16_14205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGN16_14210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DGN16_14220	COG3328	transposase activity
DGN16_14275	COG0717	Belongs to the dCTP deaminase family
DGN16_14285	COG0489	protein tyrosine kinase activity
DGN16_14320	COG3590	peptidase
DGN16_14325	COG3590	peptidase
DGN16_14345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DGN16_14350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN16_14355	COG2311	Membrane
DGN16_14360	COG1047	Peptidyl-prolyl cis-trans
DGN16_14365	COG0791	NLP P60 protein
DGN16_14370	COG0791	NLP P60 protein
DGN16_14380	COG4106	trans-aconitate 2-methyltransferase activity
DGN16_14385	COG1301	dicarboxylic acid transport
DGN16_14390	COG1785	Belongs to the alkaline phosphatase family
DGN16_14400	COG0037	tRNA processing
DGN16_14405	COG1722	exodeoxyribonuclease VII activity
DGN16_14410	COG0142	geranyltranstransferase activity
DGN16_14415	COG4104	PAAR repeat-containing protein
DGN16_14425	COG0312	modulator of DNA gyrase
DGN16_14430	COG3028	Belongs to the UPF0307 family
DGN16_14435	COG0312	modulator of DNA gyrase
DGN16_14445	COG3164	Protein of unknown function
DGN16_14455	COG0424	maF-like protein
DGN16_14460	COG2968	Membrane
DGN16_14475	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DGN16_14490	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DGN16_14505	COG0495	leucyl-tRNA aminoacylation
DGN16_14515	COG3118	belongs to the thioredoxin family
DGN16_14555	COG2155	Conserved Protein
DGN16_14600	COG1132	(ABC) transporter
DGN16_14625	COG1538	Outer membrane efflux protein
DGN16_14630	COG0745	RESPONSE REGULATOR receiver
DGN16_14635	COG5000	phosphorelay sensor kinase activity
DGN16_14635	COG5002	protein histidine kinase activity
DGN16_14640	COG0475	glutathione-regulated potassium exporter activity
DGN16_14650	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DGN16_14670	COG1187	pseudouridine synthase activity
DGN16_14675	COG5001	Diguanylate cyclase
DGN16_14675	COG5002	protein histidine kinase activity
DGN16_14685	COG1595	DNA-templated transcription, initiation
DGN16_14805	COG0667	Aldo Keto reductase
DGN16_14810	COG2814	Major facilitator Superfamily
DGN16_14815	COG0583	DNA-binding transcription factor activity
DGN16_14825	COG2207	Transcriptional regulator
DGN16_14835	COG1309	transcriptional regulator
DGN16_14845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN16_14860	COG0735	belongs to the Fur family
DGN16_14865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGN16_14890	COG4452	Inner membrane protein CreD
DGN16_14900	COG2205	protein histidine kinase activity
DGN16_14905	COG0745	RESPONSE REGULATOR receiver
DGN16_14910	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DGN16_14920	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DGN16_14930	COG2198	Histidine kinase
DGN16_14930	COG0643	Histidine kinase
DGN16_14935	COG0840	transmembrane signaling receptor activity
DGN16_14940	COG0835	chemotaxis
DGN16_14945	COG2202	Pas domain
DGN16_14945	COG2199	diguanylate cyclase activity
DGN16_14945	COG2200	EAL domain
DGN16_14950	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DGN16_14955	COG2201	protein-glutamate methylesterase activity
DGN16_14960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN16_14965	COG3590	peptidase
DGN16_14975	COG0588	phosphoglycerate mutase activity
DGN16_14980	COG1515	deoxyribonuclease V activity
DGN16_14995	COG1741	Belongs to the pirin family
DGN16_15010	COG1741	Belongs to the pirin family
DGN16_15015	COG1966	Carbon starvation protein
DGN16_15020	COG2879	small protein
DGN16_15065	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DGN16_15070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DGN16_15075	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DGN16_15080	COG2080	2 iron, 2 sulfur cluster binding
DGN16_15085	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_15085	COG0604	alcohol dehydrogenase
DGN16_15085	COG3321	synthase
DGN16_15090	COG5001	Diguanylate cyclase
DGN16_15090	COG2203	Gaf domain
DGN16_15090	COG3706	GGDEF domain
DGN16_15090	COG4251	negative regulation of phosphorylation
DGN16_15095	COG0629	single-stranded DNA binding
DGN16_15100	COG0142	geranyltranstransferase activity
DGN16_15115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DGN16_15130	COG0527	aspartate kinase activity
DGN16_15135	COG0384	phenazine biosynthesis protein PhzF
DGN16_15140	COG0384	phenazine biosynthesis protein PhzF
DGN16_15150	COG1764	response to oxidative stress
DGN16_15155	COG0540	Belongs to the ATCase OTCase family
DGN16_15160	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DGN16_15165	COG1678	Uncharacterized ACR, COG1678
DGN16_15175	COG0519	Catalyzes the synthesis of GMP from XMP
DGN16_15200	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DGN16_15215	COG0739	heme binding
DGN16_15235	COG0693	protein deglycase activity
DGN16_15245	COG1959	2 iron, 2 sulfur cluster binding
DGN16_15250	COG0719	Fe-S assembly protein
DGN16_15255	COG0396	ATPase activity
DGN16_15260	COG0719	Fe-S assembly protein
DGN16_15265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DGN16_15275	COG2146	nitrite reductase [NAD(P)H] activity
DGN16_15280	COG4774	siderophore transport
DGN16_15285	COG3128	pkhd-type hydroxylase
DGN16_15310	COG1477	protein flavinylation
DGN16_15315	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGN16_15325	COG3039	Transposase
DGN16_15335	COG1555	photosystem II stabilization
DGN16_15350	COG3178	'Phosphotransferase
DGN16_15355	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DGN16_15370	COG0628	permease
DGN16_15380	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DGN16_15390	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DGN16_15410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DGN16_15415	COG0271	Belongs to the BolA IbaG family
DGN16_15425	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DGN16_15435	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DGN16_15440	COG1137	ATPase activity
DGN16_15455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGN16_15460	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DGN16_15465	COG1660	Displays ATPase and GTPase activities
DGN16_15475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGN16_15480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DGN16_15490	COG2239	Acts as a magnesium transporter
DGN16_15500	COG1294	oxidase, subunit
DGN16_15505	COG1271	oxidase subunit
DGN16_15515	COG1113	amino acid transport
DGN16_15525	COG3328	transposase activity
DGN16_15550	COG2197	response regulator
DGN16_15555	COG0531	amino acid
DGN16_15570	COG3039	Transposase
DGN16_15675	COG2814	Major facilitator Superfamily
DGN16_15690	COG0754	glutathionylspermidine amidase activity
DGN16_15715	COG1842	Phage shock protein A
DGN16_15725	COG0259	pyridoxamine-phosphate oxidase activity
DGN16_15730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DGN16_15735	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DGN16_15745	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DGN16_15750	COG2814	Major facilitator Superfamily
DGN16_15770	COG0784	Response regulator, receiver
DGN16_15770	COG2198	Histidine kinase
DGN16_15770	COG2205	protein histidine kinase activity
DGN16_15775	COG2353	YceI-like domain
DGN16_15795	COG1760	l-serine dehydratase
DGN16_15810	COG0460	homoserine dehydrogenase
DGN16_15810	COG0527	aspartate kinase activity
DGN16_15815	COG0626	cystathionine gamma-synthase activity
DGN16_15820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN16_15825	COG0739	heme binding
DGN16_15830	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DGN16_15835	COG1272	protein, Hemolysin III
DGN16_15840	COG2982	Protein involved in outer membrane biogenesis
DGN16_15845	COG0516	GMP reductase activity
DGN16_15845	COG0517	IMP dehydrogenase activity
DGN16_15850	COG0463	Glycosyl transferase, family 2
DGN16_15855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DGN16_15860	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DGN16_15870	COG4771	TonB-dependent receptor
DGN16_15875	COG3328	transposase activity
DGN16_15885	COG3039	Transposase
DGN16_15890	COG1309	transcriptional regulator
DGN16_15900	COG1960	acyl-CoA dehydrogenase activity
DGN16_15925	COG3328	transposase activity
DGN16_15945	COG0509	glycine decarboxylation via glycine cleavage system
DGN16_15950	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DGN16_15965	COG1742	UPF0060 membrane protein
DGN16_15970	COG3956	TIGRFAM MazG family protein
DGN16_15975	COG1218	3'(2'),5'-bisphosphate nucleotidase
DGN16_15980	COG0494	nUDIX hydrolase
DGN16_15990	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DGN16_15995	COG0837	glucose binding
DGN16_16010	COG1388	LysM domain
DGN16_16010	COG3858	chitin binding
DGN16_16025	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN16_16045	COG0531	amino acid
DGN16_16055	COG1486	melibiose metabolic process
DGN16_16065	COG3537	Alpha-1,2-mannosidase
DGN16_16105	COG3142	Participates in the control of copper homeostasis
DGN16_16110	COG1446	asparaginase
DGN16_16135	COG0643	Histidine kinase
DGN16_16135	COG0784	Response regulator, receiver
DGN16_16135	COG2198	Histidine kinase
DGN16_16140	COG0840	transmembrane signaling receptor activity
DGN16_16145	COG0835	chemotaxis
DGN16_16160	COG0189	ligase activity
DGN16_16170	COG1397	ADP-ribosylglycohydrolase
DGN16_16180	COG1199	ATP-dependent helicase activity
DGN16_16190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DGN16_16195	COG1215	transferase activity, transferring glycosyl groups
DGN16_16215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DGN16_16225	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DGN16_16230	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DGN16_16235	COG0535	radical SAM domain protein
DGN16_16240	COG0535	radical SAM domain protein
DGN16_16255	COG0837	glucose binding
DGN16_16265	COG1643	Atp-dependent helicase
DGN16_16270	COG0783	Belongs to the Dps family
DGN16_16275	COG0514	ATP-dependent DNA helicase (RecQ)
DGN16_16315	COG0840	transmembrane signaling receptor activity
DGN16_16335	COG3920	Histidine kinase
DGN16_16340	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DGN16_16350	COG0602	queuosine metabolic process
DGN16_16360	COG2885	chlorophyll binding
DGN16_16365	COG0823	Involved in the tonB-independent uptake of proteins
DGN16_16375	COG0848	biopolymer transport protein
DGN16_16385	COG0824	Thioesterase
DGN16_16390	COG2255	four-way junction helicase activity
DGN16_16400	COG3158	transport of potassium into the cell
DGN16_16405	COG0632	four-way junction helicase activity
DGN16_16410	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DGN16_16415	COG0217	transcriptional regulatory protein
DGN16_16430	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DGN16_16445	COG0477	Major facilitator Superfamily
DGN16_16485	COG0488	(ABC) transporter
DGN16_16530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DGN16_16530	COG4651	solute:proton antiporter activity
DGN16_16540	COG4772	TonB-dependent receptor
DGN16_16550	COG4264	IucA IucC family
DGN16_16565	COG0019	diaminopimelate decarboxylase activity
DGN16_16590	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DGN16_16600	COG1492	cobalamin metabolic process
DGN16_16610	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DGN16_16635	COG4206	TonB-dependent receptor
DGN16_16640	COG0542	response to heat
DGN16_16645	COG1116	anion transmembrane transporter activity
DGN16_16650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DGN16_16655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DGN16_16660	COG0667	Aldo Keto reductase
DGN16_16665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DGN16_16685	COG2827	Endonuclease containing a URI domain
DGN16_16725	COG1877	trehalose-phosphatase activity
DGN16_16730	COG3387	PFAM Glycoside hydrolase 15-related
DGN16_16750	COG0840	transmembrane signaling receptor activity
DGN16_16755	COG3011	Protein conserved in bacteria
DGN16_16770	COG0564	pseudouridine synthase activity
DGN16_16775	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN16_16785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DGN16_16785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGN16_16800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DGN16_16805	COG0045	succinate-CoA ligase (ADP-forming) activity
DGN16_16840	COG1459	type II secretion system
DGN16_16845	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DGN16_16850	COG0237	dephospho-CoA kinase activity
DGN16_16865	COG3039	Transposase
DGN16_16880	COG3039	Transposase
DGN16_16895	COG0745	RESPONSE REGULATOR receiver
DGN16_16905	COG0189	ligase activity
DGN16_16945	COG3039	Transposase
DGN16_16965	COG3328	transposase activity
DGN16_16980	COG3328	transposase activity
DGN16_17075	COG5001	Diguanylate cyclase
DGN16_17090	COG3039	Transposase
DGN16_17195	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DGN16_17215	COG0270	DNA (cytosine-5-)-methyltransferase activity
DGN16_17235	COG2003	Belongs to the UPF0758 family
DGN16_17280	COG3039	Transposase
DGN16_17380	COG2022	thiamine diphosphate biosynthetic process
DGN16_17385	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DGN16_17390	COG3273	potassium ion transport
DGN16_17390	COG0471	metal ion transport
DGN16_17415	COG1970	mechanosensitive ion channel activity
DGN16_17425	COG1609	Transcriptional regulator
DGN16_17435	COG3250	beta-galactosidase activity
DGN16_17440	COG4948	Mandelate Racemase Muconate Lactonizing
DGN16_17450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DGN16_17460	COG0308	aminopeptidase N
DGN16_17465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN16_17470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN16_17475	COG0529	Catalyzes the synthesis of activated sulfate
DGN16_17475	COG2895	sulfate adenylyltransferase (ATP) activity
DGN16_17480	COG0175	sulfate reduction
DGN16_17485	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGN16_17490	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DGN16_17495	COG0175	sulfate reduction
DGN16_17500	COG3039	Transposase
DGN16_17520	COG2205	protein histidine kinase activity
DGN16_17520	COG2198	Histidine kinase
DGN16_17520	COG0784	Response regulator, receiver
DGN16_17540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DGN16_17540	COG1648	precorrin-2 dehydrogenase activity
DGN16_17555	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DGN16_17560	COG3588	fructose-bisphosphate aldolase
DGN16_17575	COG0469	pyruvate kinase activity
DGN16_17585	COG0126	phosphoglycerate kinase activity
DGN16_17610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DGN16_17620	COG3047	cAMP biosynthetic process
DGN16_17625	COG3047	cAMP biosynthetic process
DGN16_17635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGN16_17635	COG3453	Protein conserved in bacteria
DGN16_17640	COG0725	ABC transporter, periplasmic molybdate-binding protein
DGN16_17645	COG4149	molybdate abc transporter
DGN16_17650	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DGN16_17685	COG1376	ErfK ybiS ycfS ynhG family protein
DGN16_17690	COG0739	heme binding
DGN16_17695	COG4773	Receptor
DGN16_17705	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DGN16_17710	COG1301	dicarboxylic acid transport
DGN16_17725	COG2304	oxidoreductase activity
DGN16_17745	COG0714	Associated with various cellular activities
DGN16_17785	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DGN16_17810	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DGN16_17820	COG2721	sulfolactate sulfo-lyase activity
DGN16_17835	COG2271	Major facilitator Superfamily
DGN16_17850	COG0583	DNA-binding transcription factor activity
DGN16_17855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DGN16_17870	COG1561	YicC-like family, N-terminal region
DGN16_17875	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DGN16_17885	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DGN16_17890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DGN16_17905	COG0006	proline dipeptidase activity
DGN16_17915	COG0006	proline dipeptidase activity
DGN16_17920	COG3079	Belongs to the UPF0149 family
DGN16_17940	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DGN16_17950	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DGN16_17960	COG2912	Transglutaminase-like superfamily
DGN16_17970	COG1773	rubredoxin
DGN16_17975	COG0352	thiamine-phosphate diphosphorylase activity
DGN16_17995	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DGN16_18010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGN16_18045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DGN16_18050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGN16_18055	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_18065	COG0671	phosphoesterase, PA-phosphatase related
DGN16_18070	COG3781	membrane
DGN16_18080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DGN16_18085	COG0563	adenylate kinase activity
DGN16_18100	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DGN16_18110	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DGN16_18135	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DGN16_18150	COG0840	transmembrane signaling receptor activity
DGN16_18155	COG0405	Gamma-glutamyltransferase
DGN16_18160	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DGN16_18180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DGN16_18185	COG0473	3-isopropylmalate dehydrogenase activity
DGN16_18190	COG0066	3-isopropylmalate dehydratase activity
DGN16_18195	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DGN16_18220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DGN16_18225	COG1538	Outer membrane efflux protein
DGN16_18230	COG1519	Transferase
DGN16_18235	COG1560	Kdo2-lipid A biosynthetic process
DGN16_18260	COG0281	malic enzyme
DGN16_18260	COG0280	phosphate acetyltransferase
DGN16_18265	COG1301	dicarboxylic acid transport
DGN16_18290	COG0583	DNA-binding transcription factor activity
DGN16_18295	COG0667	Aldo Keto reductase
DGN16_18310	COG2197	response regulator
DGN16_18320	COG0642	Histidine kinase
DGN16_18340	COG2851	Citrate transporter
DGN16_18345	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_18350	COG1609	Transcriptional regulator
DGN16_18355	COG2211	Major facilitator Superfamily
DGN16_18385	COG1162	GTPase activity
DGN16_18390	COG0436	Aminotransferase
DGN16_18405	COG0726	polysaccharide deacetylase
DGN16_18410	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DGN16_18425	COG3964	amidohydrolase
DGN16_18430	COG0402	S-adenosylhomocysteine deaminase activity
DGN16_18460	COG3039	Transposase
DGN16_18465	COG1307	EDD domain protein, DegV family
DGN16_18470	COG0242	peptide deformylase activity
DGN16_18495	COG0457	Tetratricopeptide repeat
DGN16_18500	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DGN16_18505	COG1215	transferase activity, transferring glycosyl groups
DGN16_18510	COG1215	transferase activity, transferring glycosyl groups
DGN16_18525	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DGN16_18580	COG2188	Transcriptional regulator
DGN16_18590	COG1450	Type ii and iii secretion system protein
DGN16_18605	COG3166	PFAM Fimbrial assembly family protein
DGN16_18610	COG3156	type II secretion system protein K
DGN16_18615	COG4795	General secretion pathway protein
DGN16_18620	COG2165	general secretion pathway protein
DGN16_18625	COG4970	Tfp pilus assembly protein FimT
DGN16_18630	COG2165	general secretion pathway protein
DGN16_18635	COG1459	type II secretion system
DGN16_18645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DGN16_18650	COG1404	Belongs to the peptidase S8 family
DGN16_18660	COG1404	Belongs to the peptidase S8 family
DGN16_18665	COG5295	Hep Hag repeat protein
DGN16_18670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DGN16_18670	COG0047	phosphoribosylformylglycinamidine synthase activity
DGN16_18680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DGN16_18695	COG4974	Belongs to the 'phage' integrase family
DGN16_18710	COG0795	lipopolysaccharide-transporting ATPase activity
DGN16_18720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DGN16_18740	COG0525	valine-tRNA ligase activity
DGN16_18765	COG3328	transposase activity
DGN16_18785	COG1183	phosphatidylcholine synthase activity
DGN16_18795	COG0442	prolyl-tRNA aminoacylation
DGN16_18810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DGN16_18815	COG1127	ABC transporter
DGN16_18820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DGN16_18820	COG3218	ABC-type transport auxiliary lipoprotein component
DGN16_18850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DGN16_18855	COG0662	Cupin 2, conserved barrel domain protein
DGN16_18855	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DGN16_18885	COG2086	electron transfer activity
DGN16_18900	COG0463	Glycosyl transferase, family 2
DGN16_18930	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DGN16_18935	COG0438	transferase activity, transferring glycosyl groups
DGN16_18955	COG0438	transferase activity, transferring glycosyl groups
DGN16_18965	COG0626	cystathionine gamma-synthase activity
DGN16_18995	COG0625	glutathione transferase activity
DGN16_19010	COG0513	Belongs to the DEAD box helicase family
DGN16_19020	COG4771	TonB-dependent receptor
DGN16_19030	COG0720	synthase
DGN16_19060	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DGN16_19065	COG1956	GAF domain-containing protein
DGN16_19075	COG2819	hydrolase of the alpha beta superfamily
DGN16_19085	COG0546	phosphoglycolate phosphatase activity
DGN16_19090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DGN16_19095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DGN16_19110	COG0339	signal peptide processing
DGN16_19160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DGN16_19165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN16_19170	COG1136	(ABC) transporter
DGN16_19175	COG0577	efflux transmembrane transporter activity
DGN16_19210	COG4191	Histidine kinase
DGN16_19215	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DGN16_19235	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DGN16_19240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DGN16_19245	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DGN16_19250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DGN16_19255	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DGN16_19260	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DGN16_19270	COG0356	it plays a direct role in the translocation of protons across the membrane
DGN16_19290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DGN16_19300	COG0508	dehydrogenase complex catalyzes the overall conversion of
DGN16_19340	COG2011	ABC-type metal ion transport system permease component
DGN16_19345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DGN16_19350	COG0697	spore germination
DGN16_19355	COG1666	GTP binding
DGN16_19365	COG2198	Histidine kinase
DGN16_19365	COG5002	protein histidine kinase activity
DGN16_19365	COG0784	Response regulator, receiver
DGN16_19395	COG1187	pseudouridine synthase activity
DGN16_19400	COG2813	Specifically methylates the guanine in position
DGN16_19420	COG2202	Pas domain
DGN16_19420	COG2205	protein histidine kinase activity
DGN16_19440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DGN16_19445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN16_19505	COG0842	Transport permease protein
DGN16_19510	COG1131	(ABC) transporter
DGN16_19515	COG0025	NhaP-type Na H and K H
DGN16_19525	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DGN16_19530	COG1573	uracil-dna glycosylase
DGN16_19545	COG3384	dioxygenase
DGN16_19555	COG0583	DNA-binding transcription factor activity
DGN16_19565	COG0667	Aldo Keto reductase
DGN16_19580	COG3590	peptidase
DGN16_19595	COG0531	amino acid
DGN16_19610	COG2972	Histidine kinase
DGN16_19635	COG3685	Protein conserved in bacteria
DGN16_19640	COG3546	catalase activity
DGN16_19675	COG2204	response regulator
DGN16_19690	COG1271	oxidase subunit
DGN16_19695	COG1294	oxidase, subunit
DGN16_19710	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_19715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DGN16_19735	COG1132	(ABC) transporter
DGN16_19750	COG1063	alcohol dehydrogenase
DGN16_19825	COG0251	oxidation-reduction process
DGN16_19855	COG0583	DNA-binding transcription factor activity
DGN16_19860	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DGN16_19890	COG0659	secondary active sulfate transmembrane transporter activity
DGN16_19900	COG0024	Methionine aminopeptidase
DGN16_19955	COG3039	Transposase
DGN16_20015	COG0582	viral genome integration into host DNA
DGN16_20030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DGN16_20035	COG1490	D-aminoacyl-tRNA deacylase activity
DGN16_20040	COG1560	Kdo2-lipid A biosynthetic process
DGN16_20095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DGN16_20095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DGN16_20100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DGN16_20105	COG0242	peptide deformylase activity
DGN16_20110	COG1652	LysM domain
DGN16_20115	COG0758	DNA mediated transformation
DGN16_20135	COG1754	DNA topoisomerase type I activity
DGN16_20135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DGN16_20140	COG0009	L-threonylcarbamoyladenylate synthase
DGN16_20155	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_20170	COG0616	signal peptide processing
DGN16_20175	COG0534	Mate efflux family protein
DGN16_20195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DGN16_20200	COG0625	glutathione transferase activity
DGN16_20215	COG1252	NADH dehydrogenase
DGN16_20225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DGN16_20230	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DGN16_20235	COG3437	response regulator, receiver
DGN16_20240	COG2177	Part of the ABC transporter FtsEX involved in
DGN16_20245	COG2884	Cell division ATP-binding protein ftsE
DGN16_20250	COG0513	Belongs to the DEAD box helicase family
DGN16_20255	COG3118	belongs to the thioredoxin family
DGN16_20260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DGN16_20265	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
DGN16_20270	COG0583	DNA-binding transcription factor activity
DGN16_20290	COG1652	LysM domain
DGN16_20295	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DGN16_20295	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DGN16_20300	COG1473	amidohydrolase
DGN16_20305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN16_20310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN16_20330	COG5383	Protein conserved in bacteria
DGN16_20370	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DGN16_20375	COG3023	N-Acetylmuramoyl-L-alanine amidase
DGN16_20385	COG4948	Mandelate Racemase Muconate Lactonizing
DGN16_20395	COG0531	amino acid
DGN16_20420	COG3328	transposase activity
DGN16_20430	COG2133	pyrroloquinoline quinone binding
DGN16_20440	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DGN16_20445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DGN16_20455	COG1610	YqeY-like protein
DGN16_20465	COG1295	ribonuclease BN
DGN16_20470	COG0358	DNA primase activity
DGN16_20485	COG0109	protoheme IX farnesyltransferase activity
DGN16_20515	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DGN16_20530	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DGN16_20575	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DGN16_20580	COG0739	heme binding
DGN16_20585	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DGN16_20595	COG2211	Major facilitator Superfamily
DGN16_20600	COG0708	Exodeoxyribonuclease III
DGN16_20605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DGN16_20615	COG1192	Involved in chromosome partitioning
DGN16_20620	COG1475	DNA binding
DGN16_20640	COG0463	Glycosyl transferase, family 2
DGN16_20660	COG0756	dUTP diphosphatase activity
DGN16_20665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DGN16_20670	COG2003	Belongs to the UPF0758 family
DGN16_20675	COG0018	arginyl-trna synthetase
DGN16_20690	COG4221	oxidoreductase activity
DGN16_20695	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DGN16_20695	COG2755	lipolytic protein G-D-S-L family
DGN16_20715	COG1166	arginine decarboxylase activity
DGN16_20720	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DGN16_20745	COG3291	Pkd domain containing protein
DGN16_20745	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DGN16_20765	COG0606	chelatase, subunit chli
DGN16_20780	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DGN16_20810	COG3039	Transposase
DGN16_20820	COG1690	Belongs to the RtcB family
DGN16_20855	COG1090	epimerase
DGN16_20865	COG0642	Histidine kinase
DGN16_20890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DGN16_20915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DGN16_20920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DGN16_20930	COG3328	transposase activity
DGN16_20940	COG0753	catalase activity
DGN16_20955	COG2197	response regulator
DGN16_20960	COG4585	Histidine kinase
DGN16_20965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN16_20970	COG1136	(ABC) transporter
DGN16_20995	COG0697	spore germination
DGN16_21015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGN16_21020	COG0180	Tryptophanyl-tRNA synthetase
DGN16_21025	COG3237	CsbD-like
DGN16_21065	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DGN16_21085	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DGN16_21135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DGN16_21165	COG1199	ATP-dependent helicase activity
DGN16_21180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DGN16_21250	COG0625	glutathione transferase activity
DGN16_21290	COG4555	ABC transporter
DGN16_21300	COG1476	TRANSCRIPTIONal
DGN16_21320	COG1230	cation diffusion facilitator family transporter
DGN16_21330	COG4774	siderophore transport
DGN16_21345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGN16_21350	COG1131	(ABC) transporter
DGN16_21355	COG0842	Transport permease protein
DGN16_21360	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DGN16_21390	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DGN16_21400	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DGN16_21410	COG0045	succinate-CoA ligase (ADP-forming) activity
DGN16_21410	COG1042	CoA-binding domain protein
DGN16_21410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DGN16_21415	COG2239	Acts as a magnesium transporter
DGN16_21435	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DGN16_21440	COG3387	PFAM Glycoside hydrolase 15-related
DGN16_21455	COG3100	YcgL domain-containing protein
DGN16_21460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DGN16_21470	COG0463	Glycosyl transferase, family 2
DGN16_21480	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_21515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DGN16_21530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGN16_21560	COG0823	Involved in the tonB-independent uptake of proteins
DGN16_21560	COG1506	peptidase
DGN16_21560	COG4946	Tricorn protease homolog
DGN16_21585	COG0408	coproporphyrinogen oxidase activity
DGN16_21625	COG0515	serine threonine protein kinase
DGN16_21690	COG1595	DNA-templated transcription, initiation
DGN16_21740	COG3039	Transposase
DGN16_21810	COG0210	DNA helicase
DGN16_21820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN16_21825	COG0583	DNA-binding transcription factor activity
DGN16_21830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DGN16_21870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN16_21890	COG0357	Ribosomal RNA small subunit methyltransferase G
DGN16_21895	COG3540	Alkaline phosphatase
DGN16_21905	COG2091	lysine biosynthetic process via aminoadipic acid
DGN16_21920	COG0708	Exodeoxyribonuclease III
DGN16_21925	COG1940	carbohydrate kinase activity
DGN16_21925	COG1846	Transcriptional regulator
DGN16_21935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGN16_21950	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DGN16_21955	COG3162	membrane
DGN16_21965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DGN16_22015	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_22020	COG0179	Fumarylacetoacetate (FAA) hydrolase
DGN16_22025	COG4948	Mandelate Racemase Muconate Lactonizing
DGN16_22030	COG3254	rhamnose metabolic process
DGN16_22035	COG0738	Major facilitator superfamily
DGN16_22040	COG1414	Transcriptional regulator
DGN16_22045	COG1971	Probably functions as a manganese efflux pump
DGN16_22050	COG2205	protein histidine kinase activity
DGN16_22065	COG3459	Glycosyltransferase 36 associated
DGN16_22070	COG2211	Major facilitator Superfamily
DGN16_22075	COG3265	gluconokinase activity
DGN16_22085	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN16_22110	COG2911	Protein conserved in bacteria
DGN16_22115	COG0729	surface antigen
DGN16_22125	COG3039	Transposase
DGN16_22130	COG3039	Transposase
DGN16_22135	COG3039	Transposase
DGN16_22165	COG0752	glycyl-tRNA synthetase alpha subunit
DGN16_22170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DGN16_22190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DGN16_22190	COG0519	Catalyzes the synthesis of GMP from XMP
DGN16_22200	COG0805	protein transport
DGN16_22205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DGN16_22210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DGN16_22220	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DGN16_22240	COG2974	May be involved in recombination
DGN16_22245	COG0037	tRNA processing
DGN16_22255	COG2115	Belongs to the xylose isomerase family
DGN16_22265	COG3661	Belongs to the glycosyl hydrolase 67 family
DGN16_22275	COG4948	Mandelate Racemase Muconate Lactonizing
DGN16_22285	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN16_22290	COG0246	Mannitol dehydrogenase
DGN16_22370	COG3386	PFAM SMP-30 Gluconolaconase
DGN16_22380	COG3250	beta-galactosidase activity
DGN16_22385	COG1904	glucuronate isomerase
DGN16_22400	COG3693	PFAM glycoside hydrolase, family 10
DGN16_22415	COG2211	Major facilitator Superfamily
DGN16_22450	COG3321	synthase
DGN16_22450	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_22450	COG0604	alcohol dehydrogenase
DGN16_22455	COG2937	Belongs to the GPAT DAPAT family
DGN16_22490	COG3039	Transposase
DGN16_22495	COG0284	orotidine-5'-phosphate decarboxylase activity
DGN16_22500	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DGN16_22505	COG3132	Protein of unknown function, DUF480
DGN16_22530	COG0210	DNA helicase
DGN16_22535	COG1435	thymidine kinase activity
DGN16_22545	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DGN16_22555	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DGN16_22585	COG3135	benzoate transporter
DGN16_22610	COG0676	glucose-6-phosphate 1-epimerase activity
DGN16_22620	COG3012	SEC-C Motif Domain Protein
DGN16_22625	COG0730	response to heat
DGN16_22650	COG0302	gtp cyclohydrolase
DGN16_22665	COG1566	PFAM secretion protein HlyD family protein
DGN16_22675	COG1289	transmembrane transporter activity
DGN16_22680	COG0477	Major facilitator Superfamily
DGN16_22690	COG0583	DNA-binding transcription factor activity
DGN16_22695	COG4221	oxidoreductase activity
DGN16_22705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN16_22740	COG3328	transposase activity
DGN16_22765	COG0564	pseudouridine synthase activity
DGN16_22790	COG3039	Transposase
DGN16_22810	COG3039	Transposase
DGN16_22820	COG3039	Transposase
DGN16_22840	COG1028	Short-chain dehydrogenase reductase Sdr
DGN16_22885	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DGN16_22890	COG1074	ATP-dependent DNA helicase activity
DGN16_22895	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DGN16_22930	COG1127	ABC transporter
DGN16_22935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DGN16_22940	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DGN16_22955	COG2853	Lipoprotein
DGN16_22965	COG0386	Belongs to the glutathione peroxidase family
DGN16_22995	COG0625	glutathione transferase activity
DGN16_23135	COG1196	nuclear chromosome segregation
DGN16_23160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN16_23180	COG2948	multi-organism process
DGN16_23185	COG3504	Conjugal transfer protein
DGN16_23235	COG3328	transposase activity
DGN16_23260	COG1192	Involved in chromosome partitioning
DGN16_23280	COG3537	Alpha-1,2-mannosidase
DGN16_23305	COG1929	Belongs to the glycerate kinase type-1 family
DGN16_23310	COG2271	Major facilitator Superfamily
DGN16_23325	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DGN16_23335	COG0861	Integral membrane protein TerC family
DGN16_23345	COG0584	glycerophosphoryl diester phosphodiesterase
DGN16_23355	COG3039	Transposase
DGN16_23365	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DGN16_23375	COG0706	membrane insertase activity
DGN16_23380	COG0594	ribonuclease P activity
DGN16_23480	COG3328	transposase activity
DGN16_23510	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DGN16_23515	COG4691	Plasmid stability protein
DGN16_23520	COG1487	ribonuclease activity
DGN16_23780	COG3328	transposase activity
DGN16_23785	COG3328	transposase activity
DGN16_23815	COG3328	transposase activity
DGN16_23895	COG2951	lytic endotransglycosylase activity