locus-tag	class	description
FPL00_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FPL00_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FPL00_00025	COG0187	DNA topoisomerase II activity
FPL00_00035	COG0501	Belongs to the peptidase M48B family
FPL00_00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FPL00_00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL00_00120	COG0793	Belongs to the peptidase S41A family
FPL00_00125	COG4942	peptidase
FPL00_00135	COG2234	aminopeptidase activity
FPL00_00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL00_00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL00_00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL00_00170	COG1064	alcohol dehydrogenase
FPL00_00180	COG0493	'glutamate synthase
FPL00_00185	COG0070	glutamate synthase
FPL00_00185	COG0067	glutamate synthase
FPL00_00185	COG0069	glutamate synthase activity
FPL00_00235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FPL00_00250	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
FPL00_00255	COG0297	glycogen (starch) synthase activity
FPL00_00255	COG0438	transferase activity, transferring glycosyl groups
FPL00_00275	COG0367	asparagine synthase
FPL00_00305	COG1132	(ABC) transporter
FPL00_00430	COG1205	dead DEAH box helicase
FPL00_00430	COG1111	helicase
FPL00_00435	COG1272	protein, Hemolysin III
FPL00_00460	COG1028	Short-chain dehydrogenase reductase Sdr
FPL00_00485	COG2249	NAD(P)H dehydrogenase (quinone) activity
FPL00_00495	COG3237	CsbD-like
FPL00_00540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FPL00_00550	COG0477	Major facilitator Superfamily
FPL00_00590	COG0714	Associated with various cellular activities
FPL00_00620	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FPL00_00630	COG4772	TonB-dependent receptor
FPL00_00640	COG0662	Cupin 2, conserved barrel domain protein
FPL00_00645	COG1012	belongs to the aldehyde dehydrogenase family
FPL00_00670	COG1304	FMN binding
FPL00_00685	COG4585	Histidine kinase
FPL00_00690	COG2197	response regulator
FPL00_00710	COG3710	Transcriptional regulator
FPL00_00715	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FPL00_00750	COG2131	deaminase
FPL00_00805	COG0366	Alpha amylase catalytic
FPL00_00810	COG0366	Alpha amylase catalytic
FPL00_00815	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FPL00_00840	COG2755	lipolytic protein G-D-S-L family
FPL00_00840	COG0657	acetylesterase activity
FPL00_00850	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FPL00_00865	COG3507	Belongs to the glycosyl hydrolase 43 family
FPL00_00870	COG1609	Transcriptional regulator
FPL00_00890	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FPL00_00895	COG1028	Short-chain dehydrogenase reductase Sdr
FPL00_00905	COG2755	lipolytic protein G-D-S-L family
FPL00_00920	COG3186	Phenylalanine-4-hydroxylase
FPL00_00925	COG1522	sequence-specific DNA binding
FPL00_00935	COG1752	Esterase of the alpha-beta hydrolase superfamily
FPL00_00945	COG1119	ATPase activity
FPL00_00960	COG1125	glycine betaine transport
FPL00_00975	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FPL00_00995	COG3550	peptidyl-serine autophosphorylation
FPL00_01000	COG1396	sequence-specific DNA binding
FPL00_01025	COG0489	protein tyrosine kinase activity
FPL00_01030	COG2062	phosphohistidine phosphatase, SixA
FPL00_01040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL00_01090	COG1968	undecaprenyl-diphosphatase activity
FPL00_01100	COG0174	glutamine synthetase
FPL00_01105	COG0347	Belongs to the P(II) protein family
FPL00_01110	COG0004	ammonium transporteR
FPL00_01115	COG3852	Histidine kinase
FPL00_01120	COG2204	response regulator
FPL00_01125	COG2032	superoxide dismutase activity
FPL00_01130	COG2032	superoxide dismutase activity
FPL00_01140	COG0346	lactoylglutathione lyase activity
FPL00_01150	COG0183	Belongs to the thiolase family
FPL00_01185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FPL00_01190	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FPL00_01195	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FPL00_01250	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FPL00_01255	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FPL00_01260	COG4786	Flagellar basal body rod
FPL00_01265	COG4786	Flagellar basal body rod
FPL00_01295	COG1677	Flagellar hook-basal body complex protein FliE
FPL00_01300	COG1766	The M ring may be actively involved in energy transduction
FPL00_01315	COG1157	protein secretion by the type III secretion system
FPL00_01330	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FPL00_01365	COG0028	Belongs to the TPP enzyme family
FPL00_01370	COG2205	protein histidine kinase activity
FPL00_01395	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FPL00_01410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL00_01420	COG0596	Alpha beta hydrolase
FPL00_01430	COG0318	PFAM AMP-dependent synthetase and ligase
FPL00_01435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FPL00_01460	COG1181	Belongs to the D-alanine--D-alanine ligase family
FPL00_01470	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FPL00_01480	COG0564	pseudouridine synthase activity
FPL00_01500	COG1446	asparaginase
FPL00_01505	COG0339	signal peptide processing
FPL00_01540	COG0475	glutathione-regulated potassium exporter activity
FPL00_01545	COG0583	DNA-binding transcription factor activity
FPL00_01550	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FPL00_01555	COG2224	Isocitrate lyase
FPL00_01560	COG3706	GGDEF domain
FPL00_01590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FPL00_01595	COG1960	acyl-CoA dehydrogenase activity
FPL00_01650	COG0523	cobalamin synthesis protein
FPL00_01660	COG0697	spore germination
FPL00_01670	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FPL00_01675	COG1846	Transcriptional regulator
FPL00_01680	COG1764	response to oxidative stress
FPL00_01710	COG2130	NADP-dependent
FPL00_01725	COG1187	pseudouridine synthase activity
FPL00_01740	COG1643	Atp-dependent helicase
FPL00_01750	COG4807	Protein conserved in bacteria
FPL00_01755	COG2351	hydroxyisourate hydrolase activity
FPL00_01760	COG2072	flavoprotein involved in K transport
FPL00_01780	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FPL00_01815	COG1957	nucleoside hydrolase
FPL00_01825	COG2252	PERMEase
FPL00_01850	COG0084	hydrolase, TatD family'
FPL00_01865	COG0583	DNA-binding transcription factor activity
FPL00_01870	COG2814	Major facilitator Superfamily
FPL00_01885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FPL00_01890	COG1902	pentaerythritol trinitrate reductase activity
FPL00_01910	COG0745	RESPONSE REGULATOR receiver
FPL00_01915	COG2205	protein histidine kinase activity
FPL00_01920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL00_01930	COG1538	Outer membrane efflux protein
FPL00_01945	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FPL00_01950	COG0583	DNA-binding transcription factor activity
FPL00_01985	COG0702	epimerase
FPL00_01990	COG1733	regulation of RNA biosynthetic process
FPL00_02025	COG0129	dihydroxy-acid dehydratase activity
FPL00_02040	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FPL00_02100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FPL00_02105	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FPL00_02130	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FPL00_02135	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FPL00_02145	COG3485	protocatechuate 3,4-dioxygenase
FPL00_02150	COG3485	protocatechuate 3,4-dioxygenase
FPL00_02160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL00_02165	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FPL00_02180	COG1414	Transcriptional regulator
FPL00_02200	COG0445	tRNA wobble uridine modification
FPL00_02240	COG2267	carboxylic ester hydrolase activity
FPL00_02250	COG0156	8-amino-7-oxononanoate synthase activity
FPL00_02255	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FPL00_02260	COG1040	competence protein
FPL00_02265	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FPL00_02280	COG0582	viral genome integration into host DNA
FPL00_02335	COG0464	growth
FPL00_02340	COG1404	Belongs to the peptidase S8 family
FPL00_02420	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FPL00_02505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FPL00_02515	COG2354	Protein conserved in bacteria
FPL00_02520	COG3706	GGDEF domain
FPL00_02520	COG0745	RESPONSE REGULATOR receiver
FPL00_02525	COG0297	glycogen (starch) synthase activity
FPL00_02530	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FPL00_02535	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FPL00_02560	COG0702	epimerase
FPL00_02565	COG1028	Short-chain dehydrogenase reductase Sdr
FPL00_02590	COG0513	Belongs to the DEAD box helicase family
FPL00_02595	COG0508	dehydrogenase complex catalyzes the overall conversion of
FPL00_02610	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FPL00_02620	COG3483	tryptophan 2,3-dioxygenase activity
FPL00_02625	COG3104	oligopeptide transport
FPL00_02645	COG2852	Protein conserved in bacteria
FPL00_02650	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FPL00_02670	COG1320	monovalent cation:proton antiporter activity
FPL00_02675	COG2212	antiporter activity
FPL00_02685	COG0651	ATP synthesis coupled electron transport
FPL00_02690	COG1006	Multisubunit Na H antiporter MnhC subunit
FPL00_02695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FPL00_02695	COG2111	Na H antiporter
FPL00_02720	COG3179	chitinase
FPL00_02740	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FPL00_02745	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FPL00_02760	COG0456	acetyltransferase
FPL00_02765	COG1597	lipid kinase activity
FPL00_02795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FPL00_02800	COG0134	indole-3-glycerol-phosphate synthase activity
FPL00_02810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FPL00_02815	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FPL00_02825	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FPL00_02830	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FPL00_02835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FPL00_02850	COG1051	belongs to the nudix hydrolase family
FPL00_02890	COG0316	Belongs to the HesB IscA family
FPL00_02910	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FPL00_02925	COG2814	Major facilitator Superfamily
FPL00_02935	COG2814	Major facilitator Superfamily
FPL00_02940	COG1289	transmembrane transporter activity
FPL00_02950	COG0151	Belongs to the GarS family
FPL00_02960	COG0138	bifunctional purine biosynthesis protein purh
FPL00_02965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FPL00_02970	COG2267	carboxylic ester hydrolase activity
FPL00_02975	COG2453	phosphatase
FPL00_02975	COG0671	phosphoesterase, PA-phosphatase related
FPL00_03000	COG4589	Belongs to the CDS family
FPL00_03005	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FPL00_03035	COG2264	protein methyltransferase activity
FPL00_03060	COG0439	Biotin carboxylase
FPL00_03070	COG0511	ligase activity, forming carbon-carbon bonds
FPL00_03075	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FPL00_03085	COG1324	tolerance protein
FPL00_03115	COG0300	oxidoreductase activity
FPL00_03120	COG2356	endonuclease I
FPL00_03130	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FPL00_03135	COG0459	protein refolding
FPL00_03150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FPL00_03165	COG3386	PFAM SMP-30 Gluconolaconase
FPL00_03175	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FPL00_03180	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FPL00_03200	COG0778	Nitroreductase
FPL00_03205	COG2353	YceI-like domain
FPL00_03235	COG3052	prosthetic group binding
FPL00_03255	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
FPL00_03270	COG1802	Transcriptional regulator
FPL00_03400	COG4221	oxidoreductase activity
FPL00_03415	COG4221	oxidoreductase activity
FPL00_03425	COG0435	Glutathione S-transferase
FPL00_03445	COG2409	Drug exporters of the RND superfamily
FPL00_03455	COG0823	Involved in the tonB-independent uptake of proteins
FPL00_03455	COG1506	peptidase
FPL00_03475	COG3706	GGDEF domain
FPL00_03500	COG0697	spore germination
FPL00_03515	COG1113	amino acid transport
FPL00_03525	COG0598	Magnesium transport protein CorA
FPL00_03535	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FPL00_03580	COG5001	Diguanylate cyclase
FPL00_03585	COG0840	transmembrane signaling receptor activity
FPL00_03590	COG5297	Belongs to the glycosyl hydrolase family 6
FPL00_03590	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL00_03595	COG0659	secondary active sulfate transmembrane transporter activity
FPL00_03605	COG3706	GGDEF domain
FPL00_03625	COG2943	transferase activity, transferring hexosyl groups
FPL00_03635	COG3275	phosphorelay sensor kinase activity
FPL00_03645	COG0181	hydroxymethylbilane synthase activity
FPL00_03675	COG1505	serine-type exopeptidase activity
FPL00_03695	COG2832	Protein of unknown function (DUF454)
FPL00_03705	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FPL00_03715	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FPL00_03720	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FPL00_03725	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FPL00_03750	COG2226	methyltransferase
FPL00_03755	COG3300	MHYT domain
FPL00_03755	COG5001	Diguanylate cyclase
FPL00_03760	COG0308	aminopeptidase N
FPL00_03810	COG3284	Transcriptional regulator
FPL00_03820	COG1077	Cell shape determining protein MreB Mrl
FPL00_03825	COG1792	Involved in formation and maintenance of cell shape
FPL00_03840	COG0772	Belongs to the SEDS family
FPL00_03850	COG2951	lytic endotransglycosylase activity
FPL00_03855	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FPL00_03865	COG1686	Belongs to the peptidase S11 family
FPL00_03875	COG2921	Belongs to the UPF0250 family
FPL00_03880	COG0321	lipoyl(octanoyl) transferase activity
FPL00_03885	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FPL00_03900	COG0583	DNA-binding transcription factor activity
FPL00_03910	COG1056	cytidyltransferase-related domain
FPL00_03910	COG1051	belongs to the nudix hydrolase family
FPL00_03945	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FPL00_03950	COG0673	inositol 2-dehydrogenase activity
FPL00_03955	COG2823	Periplasmic or secreted lipoprotein
FPL00_03960	COG4251	negative regulation of phosphorylation
FPL00_03965	COG0784	Response regulator, receiver
FPL00_03970	COG4191	Histidine kinase
FPL00_03975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FPL00_04035	COG1459	type II secretion system
FPL00_04055	COG4795	General secretion pathway protein
FPL00_04085	COG3250	beta-galactosidase activity
FPL00_04110	COG1609	Transcriptional regulator
FPL00_04115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FPL00_04120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FPL00_04130	COG0617	tRNA 3'-terminal CCA addition
FPL00_04135	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FPL00_04140	COG1012	belongs to the aldehyde dehydrogenase family
FPL00_04145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FPL00_04160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FPL00_04175	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FPL00_04180	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FPL00_04200	COG2205	protein histidine kinase activity
FPL00_04205	COG0745	RESPONSE REGULATOR receiver
FPL00_04230	COG3791	Glutathione-dependent formaldehyde-activating
FPL00_04245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FPL00_04265	COG0488	(ABC) transporter
FPL00_04275	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FPL00_04280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FPL00_04290	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FPL00_04290	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FPL00_04310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FPL00_04315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FPL00_04320	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FPL00_04345	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FPL00_04350	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FPL00_04355	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FPL00_04360	COG2205	protein histidine kinase activity
FPL00_04365	COG0745	RESPONSE REGULATOR receiver
FPL00_04380	COG0277	FAD linked oxidase domain protein
FPL00_04385	COG1988	membrane-bound metal-dependent
FPL00_04390	COG0792	nuclease activity
FPL00_04425	COG2001	Belongs to the MraZ family
FPL00_04430	COG0275	rRNA processing
FPL00_04435	COG3116	cell division
FPL00_04445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FPL00_04450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FPL00_04455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FPL00_04465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FPL00_04470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FPL00_04475	COG1181	Belongs to the D-alanine--D-alanine ligase family
FPL00_04480	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FPL00_04495	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FPL00_04505	COG0739	heme binding
FPL00_04510	COG0653	protein targeting
FPL00_04515	COG0494	nUDIX hydrolase
FPL00_04525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FPL00_04540	COG0604	alcohol dehydrogenase
FPL00_04540	COG1028	Short-chain dehydrogenase reductase Sdr
FPL00_04540	COG3321	synthase
FPL00_04575	COG0366	Alpha amylase catalytic
FPL00_04600	COG2226	methyltransferase
FPL00_04605	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FPL00_04615	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FPL00_04655	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FPL00_04665	COG4106	trans-aconitate 2-methyltransferase activity
FPL00_04670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FPL00_04680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FPL00_04685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FPL00_04695	COG0667	Aldo Keto reductase
FPL00_04705	COG4771	TonB-dependent receptor
FPL00_04725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL00_04730	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FPL00_04740	COG2175	clavaminate synthase activity
FPL00_04750	COG4181	ATPase activity
FPL00_04765	COG0642	Histidine kinase
FPL00_04775	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FPL00_04795	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FPL00_04800	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FPL00_04815	COG3829	transcription factor binding
FPL00_04825	COG1116	anion transmembrane transporter activity
FPL00_04830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL00_04840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FPL00_04845	COG0431	NADPH-dependent FMN reductase
FPL00_04875	COG0747	negative chemotaxis
FPL00_04895	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FPL00_04900	COG2967	ApaG domain
FPL00_04905	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FPL00_04910	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FPL00_04915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FPL00_04920	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FPL00_04925	COG0123	including yeast histone deacetylase and acetoin utilization protein
FPL00_04930	COG2096	Adenosyltransferase
FPL00_04945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL00_04950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL00_04980	COG3384	dioxygenase
FPL00_04985	COG0583	DNA-binding transcription factor activity
FPL00_05000	COG1024	Enoyl-CoA hydratase
FPL00_05020	COG3386	PFAM SMP-30 Gluconolaconase
FPL00_05035	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FPL00_05055	COG0697	spore germination
FPL00_05065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FPL00_05080	COG0745	RESPONSE REGULATOR receiver
FPL00_05080	COG3706	GGDEF domain
FPL00_05090	COG2197	response regulator
FPL00_05100	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FPL00_05110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FPL00_05115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FPL00_05125	COG0583	DNA-binding transcription factor activity
FPL00_05130	COG3634	alkyl hydroperoxide reductase activity
FPL00_05140	COG2890	protein-(glutamine-N5) methyltransferase activity
FPL00_05160	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FPL00_05160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FPL00_05190	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FPL00_05210	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FPL00_05215	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FPL00_05230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FPL00_05235	COG1404	Belongs to the peptidase S8 family
FPL00_05240	COG1404	Belongs to the peptidase S8 family
FPL00_05245	COG1404	Belongs to the peptidase S8 family
FPL00_05250	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FPL00_05275	COG1295	ribonuclease BN
FPL00_05280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FPL00_05285	COG1254	Belongs to the acylphosphatase family
FPL00_05300	COG0521	Mo-molybdopterin cofactor biosynthetic process
FPL00_05310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FPL00_05315	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FPL00_05325	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FPL00_05330	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FPL00_05340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FPL00_05345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FPL00_05350	COG0193	aminoacyl-tRNA hydrolase activity
FPL00_05355	COG0012	GTP binding
FPL00_05375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FPL00_05385	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FPL00_05390	COG0250	Participates in transcription elongation, termination and antitermination
FPL00_05395	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FPL00_05400	COG0081	regulation of translation
FPL00_05405	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FPL00_05410	COG0222	ribosome binding
FPL00_05415	COG0085	RNA polymerase activity
FPL00_05420	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FPL00_05425	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FPL00_05430	COG0049	tRNA binding
FPL00_05435	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FPL00_05440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FPL00_05445	COG0051	transcription antitermination factor activity, RNA binding
FPL00_05450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FPL00_05455	COG0088	Forms part of the polypeptide exit tunnel
FPL00_05460	COG0089	rRNA binding
FPL00_05465	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FPL00_05470	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FPL00_05475	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FPL00_05480	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FPL00_05485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FPL00_05490	COG0255	Belongs to the universal ribosomal protein uL29 family
FPL00_05495	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FPL00_05500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FPL00_05505	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FPL00_05510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FPL00_05515	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FPL00_05520	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FPL00_05525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FPL00_05530	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FPL00_05535	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FPL00_05540	COG1841	ribosomal large subunit assembly
FPL00_05545	COG0200	Binds to the 23S rRNA
FPL00_05550	COG0201	protein transport
FPL00_05555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FPL00_05560	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FPL00_05565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FPL00_05570	COG0202	RNA polymerase activity
FPL00_05575	COG0203	ribosomal protein L17
FPL00_05580	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FPL00_05600	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FPL00_05610	COG0154	amidase activity
FPL00_05625	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FPL00_05630	COG0039	L-malate dehydrogenase activity
FPL00_05635	COG0625	glutathione transferase activity
FPL00_05655	COG1902	pentaerythritol trinitrate reductase activity
FPL00_05655	COG0446	pyridine nucleotide-disulphide oxidoreductase
FPL00_05660	COG0604	alcohol dehydrogenase
FPL00_05690	COG0156	8-amino-7-oxononanoate synthase activity
FPL00_05695	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FPL00_05700	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FPL00_05705	COG4208	sulfate ABC transporter
FPL00_05710	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FPL00_05720	COG1063	alcohol dehydrogenase
FPL00_05750	COG0406	alpha-ribazole phosphatase activity
FPL00_05755	COG0285	dihydrofolate synthase activity
FPL00_05775	COG2833	Protein of unknown function (DUF455)
FPL00_05795	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL00_05800	COG0671	phosphoesterase, PA-phosphatase related
FPL00_05805	COG0438	transferase activity, transferring glycosyl groups
FPL00_05815	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FPL00_05830	COG4783	chaperone-mediated protein folding
FPL00_05845	COG0473	3-isopropylmalate dehydrogenase activity
FPL00_06105	COG4695	Portal protein
FPL00_06165	COG0544	peptidyl-prolyl cis-trans isomerase activity
FPL00_06170	COG0740	serine-type endopeptidase activity
FPL00_06175	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FPL00_06205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FPL00_06215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL00_06225	COG0328	RNA-DNA hybrid ribonuclease activity
FPL00_06230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FPL00_06235	COG0631	protein serine/threonine phosphatase activity
FPL00_06250	COG0859	PFAM glycosyl transferase family 9
FPL00_06255	COG3642	lipopolysaccharide core region biosynthetic process
FPL00_06260	COG1234	tRNA 3'-trailer cleavage
FPL00_06265	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FPL00_06280	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FPL00_06285	COG0314	molybdopterin synthase activity
FPL00_06305	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FPL00_06310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FPL00_06315	COG0537	adenosine 5'-monophosphoramidase activity
FPL00_06335	COG0714	Associated with various cellular activities
FPL00_06355	COG0424	maF-like protein
FPL00_06360	COG1399	metal-binding, possibly nucleic acid-binding protein
FPL00_06365	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FPL00_06370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL00_06385	COG1028	Short-chain dehydrogenase reductase Sdr
FPL00_06390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FPL00_06400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FPL00_06405	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FPL00_06445	COG3829	transcription factor binding
FPL00_06465	COG3609	addiction module antidote protein, CC2985 family
FPL00_06500	COG2373	Large extracellular alpha-helical protein
FPL00_06520	COG4953	penicillin-binding protein 1C
FPL00_06530	COG0678	peroxiredoxin activity
FPL00_06550	COG0330	HflC and HflK could
FPL00_06555	COG0330	HflC and HflK could
FPL00_06565	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FPL00_06570	COG0308	aminopeptidase N
FPL00_06575	COG1028	Short-chain dehydrogenase reductase Sdr
FPL00_06580	COG1309	transcriptional regulator
FPL00_06640	COG0328	RNA-DNA hybrid ribonuclease activity
FPL00_06640	COG0406	alpha-ribazole phosphatase activity
FPL00_06645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FPL00_06655	COG3387	PFAM Glycoside hydrolase 15-related
FPL00_06660	COG1028	Short-chain dehydrogenase reductase Sdr
FPL00_06670	COG3537	Alpha-1,2-mannosidase
FPL00_06675	COG1028	Short-chain dehydrogenase reductase Sdr
FPL00_06695	COG0492	ferredoxin-NADP+ reductase activity
FPL00_06720	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FPL00_06725	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FPL00_06730	COG2080	2 iron, 2 sulfur cluster binding
FPL00_06765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FPL00_06780	COG0587	DNA-directed DNA polymerase activity
FPL00_06800	COG1297	OPT oligopeptide transporter protein
FPL00_06815	COG0823	Involved in the tonB-independent uptake of proteins
FPL00_06815	COG1506	peptidase
FPL00_06835	COG2207	Transcriptional regulator
FPL00_06835	COG1917	Cupin 2, conserved barrel domain protein
FPL00_06855	COG0753	catalase activity
FPL00_06860	COG0656	L-ascorbic acid biosynthetic process
FPL00_06870	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FPL00_06870	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FPL00_06875	COG2814	Major facilitator Superfamily
FPL00_06890	COG2194	sulfuric ester hydrolase activity
FPL00_06905	COG0745	RESPONSE REGULATOR receiver
FPL00_06910	COG0642	Histidine kinase
FPL00_06920	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FPL00_06925	COG2894	cell division
FPL00_06930	COG0850	regulation of cytokinetic process
FPL00_06945	COG4585	Histidine kinase
FPL00_06950	COG2197	response regulator
FPL00_06965	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FPL00_07000	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FPL00_07010	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FPL00_07030	COG1946	Acyl-CoA thioesterase
FPL00_07045	COG0824	Thioesterase
FPL00_07050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FPL00_07055	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FPL00_07060	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FPL00_07065	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FPL00_07070	COG0268	Binds directly to 16S ribosomal RNA
FPL00_07080	COG0196	riboflavin kinase activity
FPL00_07085	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FPL00_07090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FPL00_07095	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FPL00_07110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FPL00_07115	COG1845	cytochrome c oxidase, subunit III
FPL00_07120	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FPL00_07135	COG3152	Membrane
FPL00_07145	COG2207	Transcriptional regulator
FPL00_07150	COG0326	Molecular chaperone. Has ATPase activity
FPL00_07165	COG1366	Belongs to the anti-sigma-factor antagonist family
FPL00_07170	COG1366	Belongs to the anti-sigma-factor antagonist family
FPL00_07175	COG2172	sigma factor antagonist activity
FPL00_07200	COG4771	TonB-dependent receptor
FPL00_07210	COG5507	3-demethylubiquinone-9 3-methyltransferase
FPL00_07215	COG2205	protein histidine kinase activity
FPL00_07225	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FPL00_07230	COG4999	Histidine kinase
FPL00_07230	COG3850	Histidine kinase
FPL00_07230	COG3437	response regulator, receiver
FPL00_07230	COG2205	protein histidine kinase activity
FPL00_07235	COG0784	Response regulator, receiver
FPL00_07235	COG4191	Histidine kinase
FPL00_07260	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FPL00_07270	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FPL00_07280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FPL00_07285	COG0228	four-way junction DNA binding
FPL00_07290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FPL00_07295	COG0336	Belongs to the RNA methyltransferase TrmD family
FPL00_07300	COG0335	large ribosomal subunit rRNA binding
FPL00_07305	COG0534	Mate efflux family protein
FPL00_07325	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FPL00_07335	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FPL00_07360	COG2963	transposase activity
FPL00_07375	COG3250	beta-galactosidase activity
FPL00_07380	COG3867	Arabinogalactan endo-beta-1,4-galactanase
FPL00_07400	COG1960	acyl-CoA dehydrogenase activity
FPL00_07405	COG1024	Enoyl-CoA hydratase
FPL00_07440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FPL00_07445	COG0481	GTPase activity
FPL00_07460	COG0571	ribonuclease III activity
FPL00_07465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FPL00_07470	COG1381	Involved in DNA repair and RecF pathway recombination
FPL00_07480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FPL00_07490	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FPL00_07495	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
FPL00_07500	COG3046	protein related to deoxyribodipyrimidine photolyase
FPL00_07505	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL00_07515	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FPL00_07520	COG1278	Cold shock
FPL00_07540	COG1201	RNA secondary structure unwinding
FPL00_07545	COG1793	dna ligase
FPL00_07555	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FPL00_07555	COG1793	dna ligase
FPL00_07570	COG3706	GGDEF domain
FPL00_07570	COG0745	RESPONSE REGULATOR receiver
FPL00_07585	COG0183	Belongs to the thiolase family
FPL00_07610	COG1451	nucleotide metabolic process
FPL00_07615	COG5487	UPF0391 membrane protein
FPL00_07625	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FPL00_07640	COG1077	Cell shape determining protein MreB Mrl
FPL00_07645	COG1047	Peptidyl-prolyl cis-trans
FPL00_07655	COG2824	Alkylphosphonate utilization operon protein PhnA
FPL00_07665	COG1902	pentaerythritol trinitrate reductase activity
FPL00_07670	COG2814	Major facilitator Superfamily
FPL00_07705	COG0392	lysyltransferase activity
FPL00_07705	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FPL00_07715	COG0251	oxidation-reduction process
FPL00_07720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FPL00_07735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FPL00_07760	COG1595	DNA-templated transcription, initiation
FPL00_07780	COG2878	Part of a membrane complex involved in electron transport
FPL00_07790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FPL00_07790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FPL00_07805	COG1131	(ABC) transporter
FPL00_07810	COG0346	lactoylglutathione lyase activity
FPL00_07815	COG0833	amino acid
FPL00_07820	COG2040	homocysteine
FPL00_07830	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FPL00_07850	COG1695	Transcriptional regulator
FPL00_07885	COG0825	malonyl-CoA metabolic process
FPL00_07895	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FPL00_07900	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL00_07905	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL00_07910	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FPL00_07915	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL00_07930	COG0750	zinc metalloprotease
FPL00_07935	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FPL00_07940	COG0575	Belongs to the CDS family
FPL00_07945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FPL00_07950	COG0233	cytoplasmic translational termination
FPL00_07955	COG0528	UMP kinase activity
FPL00_07960	COG3706	GGDEF domain
FPL00_07960	COG0745	RESPONSE REGULATOR receiver
FPL00_07965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FPL00_07970	COG0052	Belongs to the universal ribosomal protein uS2 family
FPL00_08005	COG0024	Methionine aminopeptidase
FPL00_08010	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FPL00_08020	COG1393	Belongs to the ArsC family
FPL00_08025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FPL00_08030	COG0367	asparagine synthase
FPL00_08040	COG4774	siderophore transport
FPL00_08055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FPL00_08090	COG1566	PFAM secretion protein HlyD family protein
FPL00_08095	COG2814	Major facilitator Superfamily
FPL00_08115	COG3104	oligopeptide transport
FPL00_08145	COG0339	signal peptide processing
FPL00_08155	COG0386	Belongs to the glutathione peroxidase family
FPL00_08210	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FPL00_08215	COG0084	hydrolase, TatD family'
FPL00_08230	COG1960	acyl-CoA dehydrogenase activity
FPL00_08250	COG0367	asparagine synthase
FPL00_08260	COG0305	Participates in initiation and elongation during chromosome replication
FPL00_08265	COG0415	Belongs to the DNA photolyase family
FPL00_08285	COG0583	DNA-binding transcription factor activity
FPL00_08320	COG3706	GGDEF domain
FPL00_08330	COG3706	GGDEF domain
FPL00_08365	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FPL00_08380	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL00_08390	COG0497	DNA recombination
FPL00_08395	COG1420	regulation of RNA biosynthetic process
FPL00_08400	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FPL00_08405	COG0443	Heat shock 70 kDa protein
FPL00_08410	COG0484	heat shock protein binding
FPL00_08420	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FPL00_08450	COG0583	DNA-binding transcription factor activity
FPL00_08455	COG1132	(ABC) transporter
FPL00_08490	COG2850	peptidyl-arginine hydroxylation
FPL00_08510	COG1253	flavin adenine dinucleotide binding
FPL00_08540	COG1131	(ABC) transporter
FPL00_08545	COG1725	Transcriptional regulator
FPL00_08555	COG0386	Belongs to the glutathione peroxidase family
FPL00_08570	COG2900	Belongs to the SlyX family
FPL00_08595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FPL00_08605	COG1410	methionine synthase
FPL00_08605	COG0646	methionine synthase
FPL00_08610	COG1410	methionine synthase
FPL00_08610	COG0646	methionine synthase
FPL00_08620	COG1960	acyl-CoA dehydrogenase activity
FPL00_08625	COG1960	acyl-CoA dehydrogenase activity
FPL00_08630	COG1960	acyl-CoA dehydrogenase activity
FPL00_08635	COG1960	acyl-CoA dehydrogenase activity
FPL00_08640	COG1960	acyl-CoA dehydrogenase activity
FPL00_08660	COG0557	exoribonuclease II activity
FPL00_08670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FPL00_08675	COG3706	GGDEF domain
FPL00_08680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FPL00_08690	COG0704	Plays a role in the regulation of phosphate uptake
FPL00_08695	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FPL00_08700	COG0581	inorganic phosphate transmembrane transporter activity
FPL00_08705	COG0573	inorganic phosphate transmembrane transporter activity
FPL00_08710	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FPL00_08735	COG0659	secondary active sulfate transmembrane transporter activity
FPL00_08740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FPL00_08750	COG1024	Enoyl-CoA hydratase
FPL00_08760	COG0494	nUDIX hydrolase
FPL00_08805	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FPL00_08805	COG0116	Belongs to the methyltransferase superfamily
FPL00_08810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FPL00_08835	COG2925	Exonuclease
FPL00_08845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL00_08850	COG3844	kynureninase activity
FPL00_08860	COG0662	Cupin 2, conserved barrel domain protein
FPL00_08865	COG0288	reversible hydration of carbon dioxide
FPL00_08930	COG2808	Putative FMN-binding domain
FPL00_08950	COG0017	Asparaginyl-tRNA synthetase
FPL00_08960	COG0316	Belongs to the HesB IscA family
FPL00_08965	COG0360	Binds together with S18 to 16S ribosomal RNA
FPL00_08970	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FPL00_08975	COG0359	binds to the 23S rRNA
FPL00_08985	COG3115	cell septum assembly
FPL00_08995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FPL00_09000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FPL00_09005	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FPL00_09020	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FPL00_09030	COG4993	Dehydrogenase
FPL00_09045	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FPL00_09055	COG2986	histidine ammonia-lyase
FPL00_09060	COG1228	amidohydrolase
FPL00_09105	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FPL00_09110	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FPL00_09115	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FPL00_09120	COG1605	Chorismate mutase
FPL00_09120	COG0077	Prephenate dehydratase
FPL00_09125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FPL00_09140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FPL00_09145	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FPL00_09150	COG0583	DNA-binding transcription factor activity
FPL00_09165	COG0840	transmembrane signaling receptor activity
FPL00_09190	COG5002	protein histidine kinase activity
FPL00_09190	COG0784	Response regulator, receiver
FPL00_09190	COG2205	protein histidine kinase activity
FPL00_09200	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
FPL00_09205	COG0784	Response regulator, receiver
FPL00_09205	COG4191	Histidine kinase
FPL00_09220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FPL00_09230	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FPL00_09240	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FPL00_09255	COG1595	DNA-templated transcription, initiation
FPL00_09310	COG2244	polysaccharide biosynthetic process
FPL00_09340	COG2264	protein methyltransferase activity
FPL00_09365	COG1136	(ABC) transporter
FPL00_09375	COG0477	Major facilitator Superfamily
FPL00_09380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FPL00_09395	COG1253	flavin adenine dinucleotide binding
FPL00_09410	COG0306	phosphate transporter
FPL00_09435	COG0504	CTP synthase activity
FPL00_09440	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FPL00_09450	COG0148	phosphopyruvate hydratase activity
FPL00_09455	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FPL00_09460	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FPL00_09465	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FPL00_09470	COG0585	pseudouridine synthase activity
FPL00_09475	COG2840	Smr protein MutS2
FPL00_09480	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FPL00_09485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FPL00_09490	COG1238	metal cluster binding
FPL00_09510	COG1534	Rna-binding protein
FPL00_09515	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FPL00_09520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FPL00_09525	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FPL00_09530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FPL00_09535	COG1923	regulation of RNA biosynthetic process
FPL00_09540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FPL00_09545	COG1546	Belongs to the CinA family
FPL00_09555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FPL00_09560	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FPL00_09570	COG2137	regulation of response to DNA damage stimulus
FPL00_09575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FPL00_09580	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FPL00_09600	COG1741	Belongs to the pirin family
FPL00_09605	COG0583	DNA-binding transcription factor activity
FPL00_09630	COG0351	phosphomethylpyrimidine kinase
FPL00_09645	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FPL00_09650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FPL00_09665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FPL00_09675	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FPL00_09680	COG3734	2-keto-3-deoxy-galactonokinase
FPL00_09690	COG4948	Mandelate Racemase Muconate Lactonizing
FPL00_09695	COG0800	Aldolase
FPL00_09735	COG1501	Belongs to the glycosyl hydrolase 31 family
FPL00_09745	COG1070	Carbohydrate kinase
FPL00_09750	COG2115	Belongs to the xylose isomerase family
FPL00_09755	COG0477	Major facilitator Superfamily
FPL00_09775	COG0860	N-Acetylmuramoyl-L-alanine amidase
FPL00_09780	COG1469	GTP cyclohydrolase I activity
FPL00_09800	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FPL00_09805	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FPL00_09810	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FPL00_09815	COG0166	Belongs to the GPI family
FPL00_09840	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL00_09855	COG3706	GGDEF domain
FPL00_09855	COG5001	Diguanylate cyclase
FPL00_09855	COG4251	negative regulation of phosphorylation
FPL00_09855	COG2203	Gaf domain
FPL00_09865	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL00_09870	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FPL00_09880	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FPL00_09885	COG0671	phosphoesterase, PA-phosphatase related
FPL00_09900	COG1794	racemase activity, acting on amino acids and derivatives
FPL00_09910	COG0697	spore germination
FPL00_09915	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FPL00_09920	COG0167	dihydroorotate dehydrogenase activity
FPL00_09940	COG1012	belongs to the aldehyde dehydrogenase family
FPL00_10000	COG2003	Belongs to the UPF0758 family
FPL00_10075	COG0758	DNA mediated transformation
FPL00_10175	COG2814	Major facilitator Superfamily
FPL00_10290	COG1215	transferase activity, transferring glycosyl groups
FPL00_10295	COG1649	PFAM Uncharacterised BCR, COG1649
FPL00_10295	COG0726	polysaccharide deacetylase
FPL00_10385	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FPL00_10420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FPL00_10425	COG0124	histidyl-tRNA synthetase
FPL00_10435	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FPL00_10440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FPL00_10445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FPL00_10450	COG0131	Imidazoleglycerol-phosphate dehydratase
FPL00_10450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FPL00_10455	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FPL00_10460	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FPL00_10465	COG0107	imidazoleglycerol-phosphate synthase activity
FPL00_10470	COG0140	phosphoribosyl-ATP diphosphatase activity
FPL00_10470	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FPL00_10485	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
FPL00_10490	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FPL00_10495	COG0235	Class ii aldolase
FPL00_10500	COG0531	amino acid
FPL00_10505	COG0531	amino acid
FPL00_10515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FPL00_10520	COG0277	FAD linked oxidase domain protein
FPL00_10540	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FPL00_10585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FPL00_10590	COG2258	MOSC domain
FPL00_10595	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FPL00_10600	COG0505	Belongs to the CarA family
FPL00_10610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FPL00_10615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FPL00_10625	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FPL00_10635	COG3279	Response regulator of the LytR AlgR family
FPL00_10645	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FPL00_10660	COG2205	protein histidine kinase activity
FPL00_10660	COG0784	Response regulator, receiver
FPL00_10660	COG2198	Histidine kinase
FPL00_10665	COG1024	Enoyl-CoA hydratase
FPL00_10670	COG0318	PFAM AMP-dependent synthetase and ligase
FPL00_10700	COG2267	carboxylic ester hydrolase activity
FPL00_10710	COG2201	protein-glutamate methylesterase activity
FPL00_10715	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FPL00_10725	COG0840	transmembrane signaling receptor activity
FPL00_10735	COG0835	chemotaxis
FPL00_10750	COG0840	transmembrane signaling receptor activity
FPL00_10755	COG0840	transmembrane signaling receptor activity
FPL00_10760	COG0840	transmembrane signaling receptor activity
FPL00_10770	COG0840	transmembrane signaling receptor activity
FPL00_10780	COG0840	transmembrane signaling receptor activity
FPL00_10785	COG0840	transmembrane signaling receptor activity
FPL00_10790	COG0840	transmembrane signaling receptor activity
FPL00_10795	COG0840	transmembrane signaling receptor activity
FPL00_10810	COG0840	transmembrane signaling receptor activity
FPL00_10815	COG0840	transmembrane signaling receptor activity
FPL00_10830	COG0643	Histidine kinase
FPL00_10830	COG2198	Histidine kinase
FPL00_10835	COG0745	RESPONSE REGULATOR receiver
FPL00_10845	COG0835	chemotaxis
FPL00_10850	COG1192	Involved in chromosome partitioning
FPL00_10855	COG1360	Flagellar Motor Protein
FPL00_10860	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FPL00_10960	COG0641	radical SAM
FPL00_10975	COG0643	Histidine kinase
FPL00_10975	COG2198	Histidine kinase
FPL00_10995	COG0455	bacterial-type flagellum organization
FPL00_11005	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FPL00_11020	COG3300	MHYT domain
FPL00_11020	COG5001	Diguanylate cyclase
FPL00_11030	COG3300	MHYT domain
FPL00_11030	COG5001	Diguanylate cyclase
FPL00_11035	COG1684	flagellar biosynthetic protein fliR
FPL00_11040	COG1987	bacterial-type flagellum assembly
FPL00_11050	COG3190	flagellar
FPL00_11100	COG1677	Flagellar hook-basal body complex protein FliE
FPL00_11135	COG1028	Short-chain dehydrogenase reductase Sdr
FPL00_11140	COG1028	Short-chain dehydrogenase reductase Sdr
FPL00_11145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL00_11160	COG2204	response regulator
FPL00_11165	COG2201	protein-glutamate methylesterase activity
FPL00_11195	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FPL00_11200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FPL00_11205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FPL00_11215	COG1705	Flagellar rod assembly protein muramidase FlgJ
FPL00_11215	COG3951	Flagellar rod assembly protein muramidase FlgJ
FPL00_11220	COG1706	bacterial-type flagellum-dependent cell motility
FPL00_11225	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FPL00_11230	COG4786	Flagellar basal body rod
FPL00_11240	COG4787	bacterial-type flagellum-dependent cell motility
FPL00_11245	COG1749	Flagellar hook protein flgE
FPL00_11250	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FPL00_11255	COG1558	bacterial-type flagellum-dependent cell motility
FPL00_11265	COG0784	Response regulator, receiver
FPL00_11265	COG0835	chemotaxis
FPL00_11285	COG5002	protein histidine kinase activity
FPL00_11315	COG2915	High frequency lysogenization protein hflD homolog
FPL00_11320	COG0482	sulfurtransferase activity
FPL00_11330	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FPL00_11335	COG0542	response to heat
FPL00_11340	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FPL00_11345	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FPL00_11355	COG0492	ferredoxin-NADP+ reductase activity
FPL00_11360	COG1674	ftsk spoiiie
FPL00_11370	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FPL00_11380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FPL00_11385	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FPL00_11395	COG0183	Belongs to the thiolase family
FPL00_11400	COG1024	Enoyl-CoA hydratase
FPL00_11400	COG1250	3-hydroxyacyl-CoA dehydrogenase
FPL00_11410	COG0105	UTP biosynthetic process
FPL00_11415	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FPL00_11425	COG1426	Protein conserved in bacteria
FPL00_11435	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL00_11440	COG1160	GTP binding
FPL00_11445	COG0303	'Molybdopterin
FPL00_11450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FPL00_11490	COG0708	Exodeoxyribonuclease III
FPL00_11500	COG0303	'Molybdopterin
FPL00_11505	COG0746	molybdenum cofactor guanylyltransferase activity
FPL00_11515	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FPL00_11515	COG1648	precorrin-2 dehydrogenase activity
FPL00_11545	COG3685	Protein conserved in bacteria
FPL00_11565	COG5001	Diguanylate cyclase
FPL00_11575	COG4566	intracellular signal transduction
FPL00_11615	COG3275	phosphorelay sensor kinase activity
FPL00_11620	COG3279	Response regulator of the LytR AlgR family
FPL00_11655	COG1238	metal cluster binding
FPL00_11685	COG1028	Short-chain dehydrogenase reductase Sdr
FPL00_11690	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FPL00_11695	COG2226	methyltransferase
FPL00_11695	COG1073	alpha beta
FPL00_11745	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FPL00_11745	COG0316	Belongs to the HesB IscA family
FPL00_11750	COG2154	pterin-4-alpha-carbinolamine dehydratase
FPL00_11760	COG0428	transporter
FPL00_11765	COG3064	Membrane
FPL00_11775	COG1530	ribonuclease E activity
FPL00_11805	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FPL00_11845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FPL00_11850	COG0322	excinuclease ABC activity
FPL00_11860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FPL00_11865	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FPL00_11875	COG1663	tetraacyldisaccharide 4'-kinase activity
FPL00_11880	COG1132	(ABC) transporter
FPL00_11890	COG0811	peptide transport
FPL00_11905	COG1136	(ABC) transporter
FPL00_11910	COG4591	ABC-type transport system involved in lipoprotein release permease component
FPL00_11920	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FPL00_11925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FPL00_11940	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FPL00_11965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FPL00_11970	COG0837	glucose binding
FPL00_11975	COG0363	glucosamine-6-phosphate deaminase activity
FPL00_11980	COG0129	dihydroxy-acid dehydratase activity
FPL00_11985	COG0800	Aldolase
FPL00_12060	COG0784	Response regulator, receiver
FPL00_12060	COG2205	protein histidine kinase activity
FPL00_12065	COG2183	response to ionizing radiation
FPL00_12075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL00_12075	COG0723	plastoquinol--plastocyanin reductase activity
FPL00_12090	COG3243	poly(R)-hydroxyalkanoic acid synthase
FPL00_12100	COG1183	phosphatidylcholine synthase activity
FPL00_12105	COG1028	Short-chain dehydrogenase reductase Sdr
FPL00_12120	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FPL00_12130	COG0668	transmembrane transport
FPL00_12135	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FPL00_12140	COG0590	tRNA wobble adenosine to inosine editing
FPL00_12145	COG1321	iron dependent repressor
FPL00_12150	COG1914	H( )-stimulated, divalent metal cation uptake system
FPL00_12170	COG2814	Major facilitator Superfamily
FPL00_12185	COG1335	isochorismatase
FPL00_12200	COG2197	response regulator
FPL00_12220	COG0583	DNA-binding transcription factor activity
FPL00_12225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FPL00_12230	COG3002	Belongs to the UPF0753 family
FPL00_12235	COG0519	Catalyzes the synthesis of GMP from XMP
FPL00_12235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FPL00_12245	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FPL00_12255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FPL00_12255	COG0475	glutathione-regulated potassium exporter activity
FPL00_12265	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FPL00_12275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FPL00_12280	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FPL00_12290	COG0776	regulation of translation
FPL00_12295	COG0539	negative regulation of cytoplasmic translation
FPL00_12300	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FPL00_12305	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FPL00_12320	COG2957	Belongs to the agmatine deiminase family
FPL00_12325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FPL00_12350	COG0395	ABC-type sugar transport system, permease component
FPL00_12355	COG1175	transmembrane transport
FPL00_12385	COG2350	Protein conserved in bacteria
FPL00_12390	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FPL00_12395	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FPL00_12400	COG1187	pseudouridine synthase activity
FPL00_12420	COG0436	Aminotransferase
FPL00_12425	COG4133	protoheme IX ABC transporter activity
FPL00_12445	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FPL00_12450	COG1138	Cytochrome C-type biogenesis protein
FPL00_12470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL00_12475	COG1278	Cold shock
FPL00_12480	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FPL00_12485	COG4988	ABC transporter
FPL00_12495	COG1294	oxidase, subunit
FPL00_12525	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FPL00_12530	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FPL00_12540	COG0165	Argininosuccinate lyase
FPL00_12545	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FPL00_12555	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FPL00_12570	COG0137	argininosuccinate synthase activity
FPL00_12575	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FPL00_12585	COG0215	cysteine-tRNA ligase activity
FPL00_12590	COG2166	iron-sulfur cluster assembly
FPL00_12600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FPL00_12605	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FPL00_12610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FPL00_12640	COG4302	ethanolamine ammonia-lyase activity
FPL00_12705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FPL00_12710	COG0402	S-adenosylhomocysteine deaminase activity
FPL00_12720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FPL00_12725	COG1509	lysine 2,3-aminomutase activity
FPL00_12730	COG3300	MHYT domain
FPL00_12730	COG5001	Diguanylate cyclase
FPL00_12745	COG0483	inositol monophosphate 1-phosphatase activity
FPL00_12775	COG0513	Belongs to the DEAD box helicase family
FPL00_12780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FPL00_12785	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FPL00_12795	COG0625	glutathione transferase activity
FPL00_12805	COG4681	YaeQ
FPL00_12810	COG2081	HI0933 family
FPL00_12820	COG0501	Belongs to the peptidase M48B family
FPL00_12825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FPL00_12830	COG1028	Short-chain dehydrogenase reductase Sdr
FPL00_12855	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FPL00_12860	COG0860	N-Acetylmuramoyl-L-alanine amidase
FPL00_12865	COG0802	atpase or kinase
FPL00_12870	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FPL00_12870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FPL00_12875	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FPL00_12880	COG1570	exodeoxyribonuclease VII activity
FPL00_12890	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FPL00_12935	COG0835	chemotaxis
FPL00_12940	COG0840	transmembrane signaling receptor activity
FPL00_12945	COG2094	Belongs to the DNA glycosylase MPG family
FPL00_12950	COG1201	RNA secondary structure unwinding
FPL00_12970	COG2969	positive regulation of protein catabolic process
FPL00_12975	COG0625	glutathione transferase activity
FPL00_12980	COG2857	Cytochrome c1
FPL00_12985	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FPL00_12990	COG0723	plastoquinol--plastocyanin reductase activity
FPL00_13000	COG0741	lytic transglycosylase activity
FPL00_13015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FPL00_13025	COG1702	phosphate starvation-inducible protein PhoH
FPL00_13035	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FPL00_13045	COG4535	Mg2 and Co2 transporter CorC
FPL00_13060	COG1012	belongs to the aldehyde dehydrogenase family
FPL00_13065	COG1177	transmembrane transport
FPL00_13070	COG1176	ABC-type spermidine putrescine transport system, permease component I
FPL00_13095	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FPL00_13115	COG0174	glutamine synthetase
FPL00_13120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL00_13125	COG0745	RESPONSE REGULATOR receiver
FPL00_13125	COG3706	GGDEF domain
FPL00_13130	COG2703	oxygen carrier activity
FPL00_13135	COG0477	Major facilitator Superfamily
FPL00_13150	COG0243	molybdopterin cofactor binding
FPL00_13155	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FPL00_13185	COG2733	membrane
FPL00_13190	COG0784	Response regulator, receiver
FPL00_13190	COG2205	protein histidine kinase activity
FPL00_13190	COG5002	protein histidine kinase activity
FPL00_13200	COG0477	Major facilitator Superfamily
FPL00_13215	COG2902	Dehydrogenase
FPL00_13225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL00_13230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL00_13240	COG1609	Transcriptional regulator
FPL00_13245	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FPL00_13245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FPL00_13250	COG1105	Belongs to the carbohydrate kinase PfkB family
FPL00_13255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FPL00_13255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FPL00_13275	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FPL00_13285	COG1862	Preprotein translocase
FPL00_13290	COG0343	queuine tRNA-ribosyltransferase activity
FPL00_13295	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FPL00_13335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FPL00_13340	COG3291	Pkd domain containing protein
FPL00_13345	COG0405	Gamma-glutamyltransferase
FPL00_13350	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FPL00_13365	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FPL00_13370	COG0742	ribosomal rna small subunit methyltransferase
FPL00_13375	COG0326	Molecular chaperone. Has ATPase activity
FPL00_13505	COG0531	amino acid
FPL00_13520	COG0006	proline dipeptidase activity
FPL00_13530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FPL00_13545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL00_13550	COG3938	Belongs to the proline racemase family
FPL00_13560	COG0552	protein localization to endoplasmic reticulum
FPL00_13570	COG1194	a g-specific adenine glycosylase
FPL00_13575	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FPL00_13580	COG4191	Histidine kinase
FPL00_13580	COG0784	Response regulator, receiver
FPL00_13595	COG0322	excinuclease ABC activity
FPL00_13610	COG3040	lipid binding
FPL00_13625	COG1960	acyl-CoA dehydrogenase activity
FPL00_13635	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FPL00_13655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FPL00_13660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL00_13665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL00_13700	COG0438	transferase activity, transferring glycosyl groups
FPL00_13705	COG0438	transferase activity, transferring glycosyl groups
FPL00_13750	COG0776	regulation of translation
FPL00_13755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FPL00_13755	COG0072	phenylalanine-tRNA ligase activity
FPL00_13760	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FPL00_13765	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FPL00_13770	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FPL00_13775	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FPL00_13780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FPL00_13795	COG2211	Major facilitator Superfamily
FPL00_13805	COG1082	Xylose isomerase domain protein TIM barrel
FPL00_13820	COG0366	Alpha amylase catalytic
FPL00_13860	COG3702	type iv secretory pathway
FPL00_13880	COG2948	multi-organism process
FPL00_13900	COG3505	Type IV secretory pathway VirD4
FPL00_13915	COG0556	nucleotide-excision repair
FPL00_13960	COG1611	Belongs to the LOG family
FPL00_13975	COG2095	MarC family integral membrane protein
FPL00_13985	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FPL00_13990	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FPL00_14020	COG1185	polyribonucleotide nucleotidyltransferase activity
FPL00_14025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FPL00_14030	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FPL00_14035	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FPL00_14040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FPL00_14045	COG0195	Participates in both transcription termination and antitermination
FPL00_14050	COG0779	Required for maturation of 30S ribosomal subunits
FPL00_14060	COG1007	ATP synthesis coupled electron transport
FPL00_14075	COG0713	ATP synthesis coupled electron transport
FPL00_14085	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL00_14090	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FPL00_14100	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FPL00_14105	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FPL00_14110	COG0649	NAD binding
FPL00_14115	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL00_14120	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL00_14125	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL00_14140	COG0149	triose-phosphate isomerase activity
FPL00_14145	COG0300	oxidoreductase activity
FPL00_14175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FPL00_14180	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FPL00_14185	COG0159	tryptophan synthase activity
FPL00_14195	COG0133	tryptophan synthase activity
FPL00_14205	COG0135	phosphoribosylanthranilate isomerase activity
FPL00_14210	COG0101	tRNA pseudouridine synthase activity
FPL00_14230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FPL00_14235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FPL00_14240	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FPL00_14245	COG2890	protein-(glutamine-N5) methyltransferase activity
FPL00_14255	COG0688	phosphatidylethanolamine metabolic process
FPL00_14270	COG0433	COG0433 Predicted ATPase
FPL00_14275	COG0494	nUDIX hydrolase
FPL00_14295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FPL00_14300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FPL00_14310	COG2336	PFAM SpoVT AbrB
FPL00_14350	COG0420	3'-5' exonuclease activity
FPL00_14365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FPL00_14390	COG0717	Belongs to the dCTP deaminase family
FPL00_14400	COG0489	protein tyrosine kinase activity
FPL00_14420	COG3590	peptidase
FPL00_14430	COG3590	peptidase
FPL00_14450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FPL00_14455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL00_14460	COG2311	Membrane
FPL00_14465	COG1047	Peptidyl-prolyl cis-trans
FPL00_14470	COG0791	NLP P60 protein
FPL00_14475	COG0791	NLP P60 protein
FPL00_14485	COG4106	trans-aconitate 2-methyltransferase activity
FPL00_14490	COG1301	dicarboxylic acid transport
FPL00_14495	COG1785	Belongs to the alkaline phosphatase family
FPL00_14505	COG0037	tRNA processing
FPL00_14510	COG1722	exodeoxyribonuclease VII activity
FPL00_14515	COG0142	geranyltranstransferase activity
FPL00_14520	COG4104	PAAR repeat-containing protein
FPL00_14530	COG0312	modulator of DNA gyrase
FPL00_14535	COG3028	Belongs to the UPF0307 family
FPL00_14540	COG0312	modulator of DNA gyrase
FPL00_14550	COG3164	Protein of unknown function
FPL00_14555	COG1530	ribonuclease E activity
FPL00_14560	COG0424	maF-like protein
FPL00_14565	COG2968	Membrane
FPL00_14580	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FPL00_14595	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FPL00_14610	COG0495	leucyl-tRNA aminoacylation
FPL00_14620	COG3118	belongs to the thioredoxin family
FPL00_14645	COG2155	Conserved Protein
FPL00_14650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FPL00_14690	COG1132	(ABC) transporter
FPL00_14720	COG1538	Outer membrane efflux protein
FPL00_14725	COG0745	RESPONSE REGULATOR receiver
FPL00_14730	COG5002	protein histidine kinase activity
FPL00_14730	COG5000	phosphorelay sensor kinase activity
FPL00_14735	COG0475	glutathione-regulated potassium exporter activity
FPL00_14740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FPL00_14745	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FPL00_14770	COG1187	pseudouridine synthase activity
FPL00_14775	COG5001	Diguanylate cyclase
FPL00_14775	COG5002	protein histidine kinase activity
FPL00_14885	COG2951	lytic endotransglycosylase activity
FPL00_14890	COG4644	lycopene metabolic process
FPL00_14905	COG2369	cell adhesion
FPL00_14955	COG0667	Aldo Keto reductase
FPL00_14960	COG2814	Major facilitator Superfamily
FPL00_14965	COG0583	DNA-binding transcription factor activity
FPL00_14970	COG2207	Transcriptional regulator
FPL00_14985	COG0667	Aldo Keto reductase
FPL00_14990	COG1309	transcriptional regulator
FPL00_14995	COG1538	Outer membrane efflux protein
FPL00_15000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL00_15015	COG0735	belongs to the Fur family
FPL00_15020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FPL00_15045	COG4452	Inner membrane protein CreD
FPL00_15060	COG2205	protein histidine kinase activity
FPL00_15065	COG0745	RESPONSE REGULATOR receiver
FPL00_15070	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FPL00_15085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FPL00_15095	COG2198	Histidine kinase
FPL00_15095	COG0643	Histidine kinase
FPL00_15100	COG0840	transmembrane signaling receptor activity
FPL00_15105	COG0835	chemotaxis
FPL00_15110	COG2199	diguanylate cyclase activity
FPL00_15110	COG2200	EAL domain
FPL00_15110	COG2202	Pas domain
FPL00_15115	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FPL00_15120	COG2201	protein-glutamate methylesterase activity
FPL00_15125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL00_15130	COG3590	peptidase
FPL00_15140	COG0588	phosphoglycerate mutase activity
FPL00_15145	COG1515	deoxyribonuclease V activity
FPL00_15155	COG1741	Belongs to the pirin family
FPL00_15170	COG1741	Belongs to the pirin family
FPL00_15175	COG1966	Carbon starvation protein
FPL00_15180	COG2879	small protein
FPL00_15225	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FPL00_15230	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FPL00_15235	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FPL00_15240	COG2080	2 iron, 2 sulfur cluster binding
FPL00_15250	COG4251	negative regulation of phosphorylation
FPL00_15250	COG5001	Diguanylate cyclase
FPL00_15250	COG3706	GGDEF domain
FPL00_15250	COG2203	Gaf domain
FPL00_15255	COG0629	single-stranded DNA binding
FPL00_15260	COG0142	geranyltranstransferase activity
FPL00_15270	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FPL00_15285	COG0527	aspartate kinase activity
FPL00_15290	COG0384	phenazine biosynthesis protein PhzF
FPL00_15295	COG0384	phenazine biosynthesis protein PhzF
FPL00_15305	COG1764	response to oxidative stress
FPL00_15310	COG0540	Belongs to the ATCase OTCase family
FPL00_15315	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FPL00_15320	COG1678	Uncharacterized ACR, COG1678
FPL00_15330	COG0519	Catalyzes the synthesis of GMP from XMP
FPL00_15355	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FPL00_15370	COG0739	heme binding
FPL00_15390	COG0693	protein deglycase activity
FPL00_15400	COG1959	2 iron, 2 sulfur cluster binding
FPL00_15405	COG0719	Fe-S assembly protein
FPL00_15410	COG0396	ATPase activity
FPL00_15415	COG0719	Fe-S assembly protein
FPL00_15420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FPL00_15435	COG4774	siderophore transport
FPL00_15440	COG3128	pkhd-type hydroxylase
FPL00_15465	COG1477	protein flavinylation
FPL00_15470	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FPL00_15485	COG1555	photosystem II stabilization
FPL00_15500	COG3178	'Phosphotransferase
FPL00_15505	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FPL00_15515	COG0628	permease
FPL00_15525	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FPL00_15535	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FPL00_15555	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FPL00_15560	COG0271	Belongs to the BolA IbaG family
FPL00_15570	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FPL00_15580	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FPL00_15585	COG1137	ATPase activity
FPL00_15600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FPL00_15605	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FPL00_15610	COG1660	Displays ATPase and GTPase activities
FPL00_15620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FPL00_15625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FPL00_15635	COG2239	Acts as a magnesium transporter
FPL00_15650	COG1294	oxidase, subunit
FPL00_15655	COG1271	oxidase subunit
FPL00_15665	COG1113	amino acid transport
FPL00_15695	COG2197	response regulator
FPL00_15700	COG0531	amino acid
FPL00_15805	COG0754	glutathionylspermidine amidase activity
FPL00_15830	COG1842	Phage shock protein A
FPL00_15840	COG0259	pyridoxamine-phosphate oxidase activity
FPL00_15845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FPL00_15850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FPL00_15860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FPL00_15865	COG0477	Major facilitator Superfamily
FPL00_15885	COG2198	Histidine kinase
FPL00_15885	COG2205	protein histidine kinase activity
FPL00_15885	COG0784	Response regulator, receiver
FPL00_15890	COG2353	YceI-like domain
FPL00_15910	COG1760	l-serine dehydratase
FPL00_15925	COG0460	homoserine dehydrogenase
FPL00_15925	COG0527	aspartate kinase activity
FPL00_15930	COG0626	cystathionine gamma-synthase activity
FPL00_15935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL00_15940	COG0739	heme binding
FPL00_15945	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FPL00_15950	COG1272	protein, Hemolysin III
FPL00_15955	COG2982	Protein involved in outer membrane biogenesis
FPL00_15960	COG0517	IMP dehydrogenase activity
FPL00_15960	COG0516	GMP reductase activity
FPL00_15965	COG0463	Glycosyl transferase, family 2
FPL00_15970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FPL00_15975	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FPL00_15985	COG4771	TonB-dependent receptor
FPL00_15990	COG1309	transcriptional regulator
FPL00_15995	COG2267	carboxylic ester hydrolase activity
FPL00_16000	COG1960	acyl-CoA dehydrogenase activity
FPL00_16030	COG0509	glycine decarboxylation via glycine cleavage system
FPL00_16035	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FPL00_16060	COG1742	UPF0060 membrane protein
FPL00_16065	COG3956	TIGRFAM MazG family protein
FPL00_16075	COG0494	nUDIX hydrolase
FPL00_16085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FPL00_16090	COG0837	glucose binding
FPL00_16105	COG1388	LysM domain
FPL00_16105	COG3858	chitin binding
FPL00_16120	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL00_16135	COG0531	amino acid
FPL00_16145	COG1486	melibiose metabolic process
FPL00_16155	COG3537	Alpha-1,2-mannosidase
FPL00_16195	COG3142	Participates in the control of copper homeostasis
FPL00_16200	COG1446	asparaginase
FPL00_16235	COG0840	transmembrane signaling receptor activity
FPL00_16240	COG0835	chemotaxis
FPL00_16255	COG0189	ligase activity
FPL00_16265	COG1397	ADP-ribosylglycohydrolase
FPL00_16275	COG1199	ATP-dependent helicase activity
FPL00_16285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FPL00_16290	COG1215	transferase activity, transferring glycosyl groups
FPL00_16305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FPL00_16315	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FPL00_16320	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
FPL00_16325	COG0535	radical SAM domain protein
FPL00_16330	COG0535	radical SAM domain protein
FPL00_16345	COG0837	glucose binding
FPL00_16360	COG1643	Atp-dependent helicase
FPL00_16365	COG0783	Belongs to the Dps family
FPL00_16370	COG0514	ATP-dependent DNA helicase (RecQ)
FPL00_16405	COG0840	transmembrane signaling receptor activity
FPL00_16425	COG3920	Histidine kinase
FPL00_16430	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FPL00_16670	COG4695	Portal protein
FPL00_16710	COG0602	queuosine metabolic process
FPL00_16720	COG2885	chlorophyll binding
FPL00_16725	COG0823	Involved in the tonB-independent uptake of proteins
FPL00_16735	COG0848	biopolymer transport protein
FPL00_16745	COG0824	Thioesterase
FPL00_16750	COG2255	four-way junction helicase activity
FPL00_16760	COG3158	transport of potassium into the cell
FPL00_16765	COG0632	four-way junction helicase activity
FPL00_16770	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FPL00_16775	COG0217	transcriptional regulatory protein
FPL00_16790	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FPL00_16890	COG2951	lytic endotransglycosylase activity
FPL00_16905	COG0477	Major facilitator Superfamily
FPL00_16945	COG0488	(ABC) transporter
FPL00_16985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FPL00_16985	COG4651	solute:proton antiporter activity
FPL00_17010	COG4772	TonB-dependent receptor
FPL00_17020	COG4264	IucA IucC family
FPL00_17035	COG0019	diaminopimelate decarboxylase activity
FPL00_17055	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FPL00_17065	COG1492	cobalamin metabolic process
FPL00_17075	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FPL00_17100	COG4206	TonB-dependent receptor
FPL00_17105	COG0542	response to heat
FPL00_17110	COG1116	anion transmembrane transporter activity
FPL00_17115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL00_17120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FPL00_17125	COG0667	Aldo Keto reductase
FPL00_17135	COG4771	TonB-dependent receptor
FPL00_17145	COG2827	Endonuclease containing a URI domain
FPL00_17190	COG1877	trehalose-phosphatase activity
FPL00_17215	COG0840	transmembrane signaling receptor activity
FPL00_17220	COG3011	Protein conserved in bacteria
FPL00_17235	COG0564	pseudouridine synthase activity
FPL00_17240	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL00_17250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FPL00_17250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FPL00_17260	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FPL00_17265	COG0045	succinate-CoA ligase (ADP-forming) activity
FPL00_17310	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FPL00_17315	COG0237	dephospho-CoA kinase activity
FPL00_17340	COG5002	protein histidine kinase activity
FPL00_17345	COG0745	RESPONSE REGULATOR receiver
FPL00_17355	COG0189	ligase activity
FPL00_17470	COG3657	addiction module killer protein
FPL00_17500	COG3209	COG3209 Rhs family protein
FPL00_17550	COG2022	thiamine diphosphate biosynthetic process
FPL00_17560	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FPL00_17565	COG3273	potassium ion transport
FPL00_17565	COG0471	metal ion transport
FPL00_17630	COG2205	protein histidine kinase activity
FPL00_17630	COG0784	Response regulator, receiver
FPL00_17645	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FPL00_17660	COG5297	Belongs to the glycosyl hydrolase family 6
FPL00_17670	COG3250	beta-galactosidase activity
FPL00_17675	COG4948	Mandelate Racemase Muconate Lactonizing
FPL00_17690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FPL00_17700	COG0308	aminopeptidase N
FPL00_17705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL00_17715	COG2895	sulfate adenylyltransferase (ATP) activity
FPL00_17715	COG0529	Catalyzes the synthesis of activated sulfate
FPL00_17720	COG0175	sulfate reduction
FPL00_17725	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FPL00_17730	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FPL00_17735	COG0175	sulfate reduction
FPL00_17775	COG1648	precorrin-2 dehydrogenase activity
FPL00_17775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FPL00_17790	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FPL00_17795	COG3588	fructose-bisphosphate aldolase
FPL00_17810	COG0469	pyruvate kinase activity
FPL00_17820	COG0126	phosphoglycerate kinase activity
FPL00_17845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FPL00_17855	COG3047	cAMP biosynthetic process
FPL00_17860	COG3047	cAMP biosynthetic process
FPL00_17870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL00_17870	COG3453	Protein conserved in bacteria
FPL00_17875	COG0725	ABC transporter, periplasmic molybdate-binding protein
FPL00_17880	COG4149	molybdate abc transporter
FPL00_17885	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FPL00_17920	COG1376	ErfK ybiS ycfS ynhG family protein
FPL00_17925	COG0739	heme binding
FPL00_17935	COG4773	Receptor
FPL00_17940	COG0596	Alpha beta hydrolase
FPL00_17945	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FPL00_17950	COG1301	dicarboxylic acid transport
FPL00_17960	COG2304	oxidoreductase activity
FPL00_17980	COG0714	Associated with various cellular activities
FPL00_18010	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FPL00_18025	COG0254	rRNA binding
FPL00_18035	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FPL00_18045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FPL00_18050	COG1758	RNA polymerase activity
FPL00_18055	COG0194	GDP metabolic process
FPL00_18060	COG1561	YicC-like family, N-terminal region
FPL00_18065	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FPL00_18075	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FPL00_18080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FPL00_18095	COG0006	proline dipeptidase activity
FPL00_18105	COG0006	proline dipeptidase activity
FPL00_18110	COG3079	Belongs to the UPF0149 family
FPL00_18130	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FPL00_18140	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FPL00_18150	COG2912	Transglutaminase-like superfamily
FPL00_18155	COG1773	rubredoxin
FPL00_18160	COG0352	thiamine-phosphate diphosphorylase activity
FPL00_18170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FPL00_18190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FPL00_18220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FPL00_18225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FPL00_18235	COG1028	Short-chain dehydrogenase reductase Sdr
FPL00_18245	COG0671	phosphoesterase, PA-phosphatase related
FPL00_18250	COG3781	membrane
FPL00_18260	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FPL00_18265	COG0563	adenylate kinase activity
FPL00_18280	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FPL00_18290	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FPL00_18315	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FPL00_18330	COG0840	transmembrane signaling receptor activity
FPL00_18335	COG0405	Gamma-glutamyltransferase
FPL00_18340	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FPL00_18360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FPL00_18370	COG0473	3-isopropylmalate dehydrogenase activity
FPL00_18375	COG0066	3-isopropylmalate dehydratase activity
FPL00_18380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FPL00_18400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FPL00_18405	COG1538	Outer membrane efflux protein
FPL00_18410	COG1519	Transferase
FPL00_18420	COG1560	Kdo2-lipid A biosynthetic process
FPL00_18450	COG0280	phosphate acetyltransferase
FPL00_18450	COG0281	malic enzyme
FPL00_18455	COG1301	dicarboxylic acid transport
FPL00_18480	COG0583	DNA-binding transcription factor activity
FPL00_18490	COG0667	Aldo Keto reductase
FPL00_18505	COG2197	response regulator
FPL00_18510	COG1840	ABC-type Fe3 transport system, periplasmic component
FPL00_18515	COG0642	Histidine kinase
FPL00_18535	COG2851	Citrate transporter
FPL00_18540	COG1028	Short-chain dehydrogenase reductase Sdr
FPL00_18550	COG2211	Major facilitator Superfamily
FPL00_18575	COG1162	GTPase activity
FPL00_18610	COG4773	Receptor
FPL00_18615	COG0726	polysaccharide deacetylase
FPL00_18620	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FPL00_18635	COG3964	amidohydrolase
FPL00_18640	COG0402	S-adenosylhomocysteine deaminase activity
FPL00_18665	COG1307	EDD domain protein, DegV family
FPL00_18670	COG0242	peptide deformylase activity
FPL00_18705	COG0457	Tetratricopeptide repeat
FPL00_18710	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FPL00_18715	COG1215	transferase activity, transferring glycosyl groups
FPL00_18720	COG1215	transferase activity, transferring glycosyl groups
FPL00_18735	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FPL00_18790	COG2188	Transcriptional regulator
FPL00_18810	COG1450	Type ii and iii secretion system protein
FPL00_18825	COG3166	PFAM Fimbrial assembly family protein
FPL00_18830	COG3156	type II secretion system protein K
FPL00_18835	COG4795	General secretion pathway protein
FPL00_18840	COG2165	general secretion pathway protein
FPL00_18845	COG4970	Tfp pilus assembly protein FimT
FPL00_18850	COG2165	general secretion pathway protein
FPL00_18855	COG1459	type II secretion system
FPL00_18860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FPL00_18865	COG1404	Belongs to the peptidase S8 family
FPL00_18870	COG5295	Hep Hag repeat protein
FPL00_18875	COG1404	Belongs to the peptidase S8 family
FPL00_18880	COG5295	Hep Hag repeat protein
FPL00_18890	COG0047	phosphoribosylformylglycinamidine synthase activity
FPL00_18890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FPL00_18905	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FPL00_18920	COG4974	Belongs to the 'phage' integrase family
FPL00_18935	COG0795	lipopolysaccharide-transporting ATPase activity
FPL00_18945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FPL00_18960	COG0525	valine-tRNA ligase activity
FPL00_18990	COG1183	phosphatidylcholine synthase activity
FPL00_19000	COG0442	prolyl-tRNA aminoacylation
FPL00_19015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FPL00_19020	COG1127	ABC transporter
FPL00_19025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FPL00_19025	COG3218	ABC-type transport auxiliary lipoprotein component
FPL00_19055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FPL00_19060	COG0662	Cupin 2, conserved barrel domain protein
FPL00_19060	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FPL00_19090	COG2086	electron transfer activity
FPL00_19105	COG0463	Glycosyl transferase, family 2
FPL00_19125	COG2813	Specifically methylates the guanine in position
FPL00_19140	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FPL00_19145	COG0438	transferase activity, transferring glycosyl groups
FPL00_19165	COG0438	transferase activity, transferring glycosyl groups
FPL00_19175	COG0626	cystathionine gamma-synthase activity
FPL00_19205	COG0625	glutathione transferase activity
FPL00_19220	COG0513	Belongs to the DEAD box helicase family
FPL00_19230	COG4206	TonB-dependent receptor
FPL00_19240	COG0720	synthase
FPL00_19250	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FPL00_19260	COG1956	GAF domain-containing protein
FPL00_19270	COG2819	hydrolase of the alpha beta superfamily
FPL00_19280	COG0546	phosphoglycolate phosphatase activity
FPL00_19285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FPL00_19290	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FPL00_19305	COG0339	signal peptide processing
FPL00_19360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FPL00_19365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL00_19370	COG1136	(ABC) transporter
FPL00_19370	COG4591	ABC-type transport system involved in lipoprotein release permease component
FPL00_19375	COG0577	efflux transmembrane transporter activity
FPL00_19390	COG2204	response regulator
FPL00_19395	COG4191	Histidine kinase
FPL00_19400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FPL00_19415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FPL00_19420	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FPL00_19425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FPL00_19430	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FPL00_19435	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FPL00_19440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FPL00_19450	COG0356	it plays a direct role in the translocation of protons across the membrane
FPL00_19470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FPL00_19480	COG0508	dehydrogenase complex catalyzes the overall conversion of
FPL00_19520	COG2011	ABC-type metal ion transport system permease component
FPL00_19525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FPL00_19530	COG0697	spore germination
FPL00_19535	COG1666	GTP binding
FPL00_19545	COG5002	protein histidine kinase activity
FPL00_19545	COG2198	Histidine kinase
FPL00_19545	COG0784	Response regulator, receiver
FPL00_19570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FPL00_19580	COG2813	Specifically methylates the guanine in position
FPL00_19600	COG2202	Pas domain
FPL00_19600	COG2205	protein histidine kinase activity
FPL00_19620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FPL00_19625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL00_19630	COG1522	sequence-specific DNA binding
FPL00_19685	COG0842	Transport permease protein
FPL00_19690	COG1131	(ABC) transporter
FPL00_19695	COG0025	NhaP-type Na H and K H
FPL00_19705	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FPL00_19710	COG1573	uracil-dna glycosylase
FPL00_19720	COG3384	dioxygenase
FPL00_19730	COG0583	DNA-binding transcription factor activity
FPL00_19740	COG0667	Aldo Keto reductase
FPL00_19755	COG3590	peptidase
FPL00_19775	COG0531	amino acid
FPL00_19790	COG2972	Histidine kinase
FPL00_19815	COG3685	Protein conserved in bacteria
FPL00_19820	COG3546	catalase activity
FPL00_19870	COG1271	oxidase subunit
FPL00_19875	COG1294	oxidase, subunit
FPL00_19890	COG1028	Short-chain dehydrogenase reductase Sdr
FPL00_19895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FPL00_19915	COG1132	(ABC) transporter
FPL00_19930	COG1063	alcohol dehydrogenase
FPL00_20005	COG0251	oxidation-reduction process
FPL00_20020	COG0840	transmembrane signaling receptor activity
FPL00_20035	COG0583	DNA-binding transcription factor activity
FPL00_20040	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FPL00_20085	COG0024	Methionine aminopeptidase
FPL00_20115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FPL00_20120	COG1490	D-aminoacyl-tRNA deacylase activity
FPL00_20125	COG1560	Kdo2-lipid A biosynthetic process
FPL00_20180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FPL00_20180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FPL00_20185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FPL00_20190	COG0242	peptide deformylase activity
FPL00_20195	COG1652	LysM domain
FPL00_20200	COG0758	DNA mediated transformation
FPL00_20220	COG1754	DNA topoisomerase type I activity
FPL00_20220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FPL00_20225	COG0009	L-threonylcarbamoyladenylate synthase
FPL00_20240	COG1028	Short-chain dehydrogenase reductase Sdr
FPL00_20255	COG0616	signal peptide processing
FPL00_20260	COG0534	Mate efflux family protein
FPL00_20280	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FPL00_20285	COG0625	glutathione transferase activity
FPL00_20300	COG1252	NADH dehydrogenase
FPL00_20305	COG2860	membrane
FPL00_20310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FPL00_20315	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FPL00_20320	COG3437	response regulator, receiver
FPL00_20325	COG2177	Part of the ABC transporter FtsEX involved in
FPL00_20330	COG2884	Cell division ATP-binding protein ftsE
FPL00_20340	COG3118	belongs to the thioredoxin family
FPL00_20345	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FPL00_20350	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
FPL00_20355	COG0583	DNA-binding transcription factor activity
FPL00_20375	COG1652	LysM domain
FPL00_20380	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FPL00_20380	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FPL00_20385	COG1473	amidohydrolase
FPL00_20390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL00_20395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL00_20405	COG5383	Protein conserved in bacteria
FPL00_20450	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FPL00_20455	COG3023	N-Acetylmuramoyl-L-alanine amidase
FPL00_20465	COG4948	Mandelate Racemase Muconate Lactonizing
FPL00_20475	COG0531	amino acid
FPL00_20490	COG4682	membrane
FPL00_20505	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FPL00_20510	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FPL00_20515	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FPL00_20520	COG1610	YqeY-like protein
FPL00_20530	COG1295	ribonuclease BN
FPL00_20535	COG0358	DNA primase activity
FPL00_20550	COG0109	protoheme IX farnesyltransferase activity
FPL00_20580	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FPL00_20595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FPL00_20640	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FPL00_20645	COG0739	heme binding
FPL00_20650	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FPL00_20660	COG2211	Major facilitator Superfamily
FPL00_20665	COG0708	Exodeoxyribonuclease III
FPL00_20670	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FPL00_20680	COG1192	Involved in chromosome partitioning
FPL00_20685	COG1475	DNA binding
FPL00_20705	COG0463	Glycosyl transferase, family 2
FPL00_20725	COG0756	dUTP diphosphatase activity
FPL00_20730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FPL00_20735	COG2003	Belongs to the UPF0758 family
FPL00_20740	COG0018	arginyl-trna synthetase
FPL00_20755	COG4221	oxidoreductase activity
FPL00_20770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL00_20775	COG1166	arginine decarboxylase activity
FPL00_20780	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FPL00_20805	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FPL00_20805	COG3291	Pkd domain containing protein
FPL00_20815	COG0347	Belongs to the P(II) protein family
FPL00_20825	COG0606	chelatase, subunit chli
FPL00_20840	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FPL00_20875	COG1690	Belongs to the RtcB family
FPL00_20910	COG1090	epimerase
FPL00_20915	COG0745	RESPONSE REGULATOR receiver
FPL00_20920	COG0642	Histidine kinase
FPL00_20950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FPL00_20975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FPL00_20980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FPL00_20995	COG0753	catalase activity
FPL00_21010	COG2197	response regulator
FPL00_21015	COG4585	Histidine kinase
FPL00_21020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL00_21025	COG1136	(ABC) transporter
FPL00_21050	COG0697	spore germination
FPL00_21070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL00_21075	COG0180	Tryptophanyl-tRNA synthetase
FPL00_21080	COG3237	CsbD-like
FPL00_21125	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FPL00_21160	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FPL00_21165	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FPL00_21165	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FPL00_21195	COG2205	protein histidine kinase activity
FPL00_21200	COG0745	RESPONSE REGULATOR receiver
FPL00_21210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FPL00_21240	COG1199	ATP-dependent helicase activity
FPL00_21255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FPL00_21320	COG0625	glutathione transferase activity
FPL00_21360	COG4555	ABC transporter
FPL00_21370	COG1476	TRANSCRIPTIONal
FPL00_21415	COG0633	Ferredoxin
FPL00_21415	COG0543	2 iron, 2 sulfur cluster binding
FPL00_21420	COG1131	(ABC) transporter
FPL00_21425	COG0842	Transport permease protein
FPL00_21435	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FPL00_21470	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FPL00_21480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FPL00_21495	COG1042	CoA-binding domain protein
FPL00_21495	COG0045	succinate-CoA ligase (ADP-forming) activity
FPL00_21495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FPL00_21500	COG2239	Acts as a magnesium transporter
FPL00_21520	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FPL00_21525	COG3387	PFAM Glycoside hydrolase 15-related
FPL00_21540	COG3100	YcgL domain-containing protein
FPL00_21545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FPL00_21555	COG0463	Glycosyl transferase, family 2
FPL00_21565	COG1028	Short-chain dehydrogenase reductase Sdr
FPL00_21600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FPL00_21615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FPL00_21645	COG0823	Involved in the tonB-independent uptake of proteins
FPL00_21645	COG1506	peptidase
FPL00_21645	COG4946	Tricorn protease homolog
FPL00_21665	COG0408	coproporphyrinogen oxidase activity
FPL00_21705	COG2815	serine threonine protein kinase
FPL00_21705	COG0515	serine threonine protein kinase
FPL00_21710	COG0631	protein serine/threonine phosphatase activity
FPL00_21745	COG3501	Rhs element vgr protein
FPL00_21900	COG0210	DNA helicase
FPL00_21915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL00_21920	COG0583	DNA-binding transcription factor activity
FPL00_21925	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FPL00_21940	COG2159	amidohydrolase
FPL00_21945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FPL00_21950	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FPL00_21970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL00_21990	COG0357	Ribosomal RNA small subunit methyltransferase G
FPL00_21995	COG3540	Alkaline phosphatase
FPL00_22005	COG2091	lysine biosynthetic process via aminoadipic acid
FPL00_22020	COG0708	Exodeoxyribonuclease III
FPL00_22025	COG1940	carbohydrate kinase activity
FPL00_22025	COG1846	Transcriptional regulator
FPL00_22035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FPL00_22045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FPL00_22050	COG3162	membrane
FPL00_22060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FPL00_22090	COG3507	Belongs to the glycosyl hydrolase 43 family
FPL00_22110	COG1028	Short-chain dehydrogenase reductase Sdr
FPL00_22115	COG0179	Fumarylacetoacetate (FAA) hydrolase
FPL00_22125	COG4948	Mandelate Racemase Muconate Lactonizing
FPL00_22130	COG3254	rhamnose metabolic process
FPL00_22135	COG0738	Major facilitator superfamily
FPL00_22140	COG1414	Transcriptional regulator
FPL00_22145	COG1971	Probably functions as a manganese efflux pump
FPL00_22150	COG2205	protein histidine kinase activity
FPL00_22165	COG3459	Glycosyltransferase 36 associated
FPL00_22170	COG2211	Major facilitator Superfamily
FPL00_22175	COG3265	gluconokinase activity
FPL00_22185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL00_22205	COG2911	Protein conserved in bacteria
FPL00_22210	COG0729	surface antigen
FPL00_22245	COG0752	glycyl-tRNA synthetase alpha subunit
FPL00_22250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FPL00_22270	COG0519	Catalyzes the synthesis of GMP from XMP
FPL00_22270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FPL00_22280	COG0805	protein transport
FPL00_22285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FPL00_22290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FPL00_22300	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FPL00_22325	COG2974	May be involved in recombination
FPL00_22330	COG0037	tRNA processing
FPL00_22340	COG2115	Belongs to the xylose isomerase family
FPL00_22350	COG3661	Belongs to the glycosyl hydrolase 67 family
FPL00_22360	COG4948	Mandelate Racemase Muconate Lactonizing
FPL00_22370	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL00_22375	COG0246	Mannitol dehydrogenase
FPL00_22425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FPL00_22455	COG3386	PFAM SMP-30 Gluconolaconase
FPL00_22465	COG3250	beta-galactosidase activity
FPL00_22470	COG1904	glucuronate isomerase
FPL00_22475	COG3693	PFAM glycoside hydrolase, family 10
FPL00_22485	COG3693	PFAM glycoside hydrolase, family 10
FPL00_22500	COG2211	Major facilitator Superfamily
FPL00_22540	COG2937	Belongs to the GPAT DAPAT family
FPL00_22575	COG0284	orotidine-5'-phosphate decarboxylase activity
FPL00_22580	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
FPL00_22590	COG3132	Protein of unknown function, DUF480
FPL00_22605	COG0210	DNA helicase
FPL00_22610	COG1435	thymidine kinase activity
FPL00_22620	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
FPL00_22630	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FPL00_22660	COG3135	benzoate transporter
FPL00_22680	COG0676	glucose-6-phosphate 1-epimerase activity
FPL00_22690	COG3012	SEC-C Motif Domain Protein
FPL00_22700	COG0730	response to heat
FPL00_22720	COG0302	gtp cyclohydrolase
FPL00_22735	COG1566	PFAM secretion protein HlyD family protein
FPL00_22745	COG1289	transmembrane transporter activity
FPL00_22750	COG0477	Major facilitator Superfamily
FPL00_22760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL00_22780	COG4691	Plasmid stability protein
FPL00_22785	COG1487	ribonuclease activity
FPL00_22820	COG0564	pseudouridine synthase activity
FPL00_22835	COG0439	Biotin carboxylase
FPL00_22875	COG1074	ATP-dependent DNA helicase activity
FPL00_22880	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FPL00_22895	COG1127	ABC transporter
FPL00_22900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FPL00_22905	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FPL00_22920	COG2853	Lipoprotein
FPL00_22930	COG0386	Belongs to the glutathione peroxidase family
FPL00_22940	COG1322	Protein conserved in bacteria
FPL00_22945	COG0604	alcohol dehydrogenase
FPL00_22950	COG0583	DNA-binding transcription factor activity
FPL00_22965	COG0625	glutathione transferase activity
FPL00_22975	COG0531	amino acid
FPL00_22980	COG3537	Alpha-1,2-mannosidase
FPL00_22995	COG3706	GGDEF domain
FPL00_23000	COG3835	regulator
FPL00_23005	COG1929	Belongs to the glycerate kinase type-1 family
FPL00_23010	COG2271	Major facilitator Superfamily
FPL00_23025	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FPL00_23035	COG0861	Integral membrane protein TerC family
FPL00_23050	COG0584	glycerophosphoryl diester phosphodiesterase
FPL00_23065	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FPL00_23070	COG0726	polysaccharide deacetylase
FPL00_23075	COG0706	membrane insertase activity
FPL00_23080	COG0594	ribonuclease P activity
FPL00_23085	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FPL00_23245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FPL00_23255	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs