locus-tag	class	description
FPL04_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FPL04_00025	COG0187	DNA topoisomerase II activity
FPL04_00035	COG0501	Belongs to the peptidase M48B family
FPL04_00070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FPL04_00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL04_00110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FPL04_00115	COG0793	Belongs to the peptidase S41A family
FPL04_00120	COG4942	peptidase
FPL04_00130	COG2234	aminopeptidase activity
FPL04_00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL04_00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL04_00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL04_00160	COG1064	alcohol dehydrogenase
FPL04_00170	COG0493	'glutamate synthase
FPL04_00175	COG0067	glutamate synthase
FPL04_00175	COG0069	glutamate synthase activity
FPL04_00175	COG0070	glutamate synthase
FPL04_00205	COG3459	Glycosyltransferase 36 associated
FPL04_00235	COG1205	dead DEAH box helicase
FPL04_00235	COG1111	helicase
FPL04_00240	COG1272	protein, Hemolysin III
FPL04_00265	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_00285	COG0583	DNA-binding transcription factor activity
FPL04_00290	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_00305	COG1733	regulation of RNA biosynthetic process
FPL04_00365	COG1733	regulation of RNA biosynthetic process
FPL04_00370	COG3237	CsbD-like
FPL04_00420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FPL04_00465	COG0714	Associated with various cellular activities
FPL04_00495	COG0596	Alpha beta hydrolase
FPL04_00505	COG1309	transcriptional regulator
FPL04_00520	COG4772	TonB-dependent receptor
FPL04_00530	COG0662	Cupin 2, conserved barrel domain protein
FPL04_00535	COG1012	belongs to the aldehyde dehydrogenase family
FPL04_00565	COG1304	FMN binding
FPL04_00570	COG1755	Isoprenylcysteine carboxyl methyltransferase
FPL04_00575	COG4585	Histidine kinase
FPL04_00580	COG2197	response regulator
FPL04_00600	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FPL04_00705	COG0366	Alpha amylase catalytic
FPL04_00710	COG0366	Alpha amylase catalytic
FPL04_00715	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FPL04_00755	COG2755	lipolytic protein G-D-S-L family
FPL04_00765	COG0657	acetylesterase activity
FPL04_00765	COG2755	lipolytic protein G-D-S-L family
FPL04_00775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FPL04_00790	COG3507	Belongs to the glycosyl hydrolase 43 family
FPL04_00795	COG1609	Transcriptional regulator
FPL04_00805	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FPL04_00810	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_00820	COG2755	lipolytic protein G-D-S-L family
FPL04_00830	COG3186	Phenylalanine-4-hydroxylase
FPL04_00835	COG1522	sequence-specific DNA binding
FPL04_00845	COG1752	Esterase of the alpha-beta hydrolase superfamily
FPL04_00855	COG1119	ATPase activity
FPL04_00870	COG1125	glycine betaine transport
FPL04_00870	COG0517	IMP dehydrogenase activity
FPL04_00885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FPL04_00890	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
FPL04_00925	COG0489	protein tyrosine kinase activity
FPL04_00930	COG2062	phosphohistidine phosphatase, SixA
FPL04_00935	COG2353	YceI-like domain
FPL04_00940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL04_00965	COG1881	PFAM PEBP family protein
FPL04_00980	COG0174	glutamine synthetase
FPL04_00985	COG0347	Belongs to the P(II) protein family
FPL04_00990	COG0004	ammonium transporteR
FPL04_00995	COG3852	Histidine kinase
FPL04_01000	COG2204	response regulator
FPL04_01005	COG2032	superoxide dismutase activity
FPL04_01010	COG2032	superoxide dismutase activity
FPL04_01015	COG0346	lactoylglutathione lyase activity
FPL04_01025	COG0183	Belongs to the thiolase family
FPL04_01065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FPL04_01075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FPL04_01085	COG0028	Belongs to the TPP enzyme family
FPL04_01090	COG2205	protein histidine kinase activity
FPL04_01115	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FPL04_01130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL04_01140	COG0596	Alpha beta hydrolase
FPL04_01150	COG0318	PFAM AMP-dependent synthetase and ligase
FPL04_01165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FPL04_01200	COG0564	pseudouridine synthase activity
FPL04_01220	COG1446	asparaginase
FPL04_01225	COG0339	signal peptide processing
FPL04_01250	COG0475	glutathione-regulated potassium exporter activity
FPL04_01255	COG0583	DNA-binding transcription factor activity
FPL04_01260	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FPL04_01265	COG2224	Isocitrate lyase
FPL04_01270	COG5001	Diguanylate cyclase
FPL04_01300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FPL04_01305	COG1960	acyl-CoA dehydrogenase activity
FPL04_01360	COG0523	cobalamin synthesis protein
FPL04_01365	COG0697	spore germination
FPL04_01375	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FPL04_01380	COG1846	Transcriptional regulator
FPL04_01385	COG1764	response to oxidative stress
FPL04_01410	COG0656	L-ascorbic acid biosynthetic process
FPL04_01415	COG2130	NADP-dependent
FPL04_01430	COG1187	pseudouridine synthase activity
FPL04_01440	COG1643	Atp-dependent helicase
FPL04_01445	COG0840	transmembrane signaling receptor activity
FPL04_01455	COG4807	Protein conserved in bacteria
FPL04_01460	COG2351	hydroxyisourate hydrolase activity
FPL04_01465	COG2072	flavoprotein involved in K transport
FPL04_01485	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FPL04_01520	COG1957	nucleoside hydrolase
FPL04_01545	COG0084	hydrolase, TatD family'
FPL04_01555	COG0583	DNA-binding transcription factor activity
FPL04_01560	COG2814	Major facilitator Superfamily
FPL04_01570	COG2267	carboxylic ester hydrolase activity
FPL04_01590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FPL04_01595	COG1902	pentaerythritol trinitrate reductase activity
FPL04_01615	COG2223	nitrite transmembrane transporter activity
FPL04_01620	COG0745	RESPONSE REGULATOR receiver
FPL04_01625	COG2205	protein histidine kinase activity
FPL04_01630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL04_01640	COG1538	Outer membrane efflux protein
FPL04_01650	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_01670	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FPL04_01675	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FPL04_01680	COG0583	DNA-binding transcription factor activity
FPL04_01695	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FPL04_01705	COG0702	epimerase
FPL04_01710	COG1733	regulation of RNA biosynthetic process
FPL04_01720	COG0840	transmembrane signaling receptor activity
FPL04_01820	COG0129	dihydroxy-acid dehydratase activity
FPL04_01840	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FPL04_01845	COG2814	Major facilitator Superfamily
FPL04_01890	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FPL04_01895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FPL04_01925	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FPL04_01930	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FPL04_01940	COG3485	protocatechuate 3,4-dioxygenase
FPL04_01945	COG3485	protocatechuate 3,4-dioxygenase
FPL04_01955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL04_01960	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FPL04_01970	COG1414	Transcriptional regulator
FPL04_01995	COG0445	tRNA wobble uridine modification
FPL04_02045	COG0156	8-amino-7-oxononanoate synthase activity
FPL04_02050	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FPL04_02055	COG1040	competence protein
FPL04_02110	COG1511	domain protein
FPL04_02110	COG3264	Mechanosensitive ion channel
FPL04_02115	COG1368	sulfuric ester hydrolase activity
FPL04_02120	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FPL04_02130	COG0745	RESPONSE REGULATOR receiver
FPL04_02130	COG3706	GGDEF domain
FPL04_02135	COG0297	glycogen (starch) synthase activity
FPL04_02140	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FPL04_02145	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FPL04_02170	COG0702	epimerase
FPL04_02175	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_02210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL04_02225	COG0513	Belongs to the DEAD box helicase family
FPL04_02235	COG0508	dehydrogenase complex catalyzes the overall conversion of
FPL04_02250	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FPL04_02265	COG3104	oligopeptide transport
FPL04_02285	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FPL04_02300	COG1320	monovalent cation:proton antiporter activity
FPL04_02305	COG2212	antiporter activity
FPL04_02315	COG0651	ATP synthesis coupled electron transport
FPL04_02320	COG1006	Multisubunit Na H antiporter MnhC subunit
FPL04_02325	COG2111	Na H antiporter
FPL04_02325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FPL04_02370	COG0484	heat shock protein binding
FPL04_02390	COG1597	lipid kinase activity
FPL04_02415	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FPL04_02420	COG0134	indole-3-glycerol-phosphate synthase activity
FPL04_02430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FPL04_02450	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FPL04_02455	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FPL04_02460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FPL04_02475	COG1051	belongs to the nudix hydrolase family
FPL04_02520	COG0316	Belongs to the HesB IscA family
FPL04_02535	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FPL04_02560	COG2814	Major facilitator Superfamily
FPL04_02565	COG1289	transmembrane transporter activity
FPL04_02570	COG0151	Belongs to the GarS family
FPL04_02575	COG0138	bifunctional purine biosynthesis protein purh
FPL04_02595	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FPL04_02615	COG2264	protein methyltransferase activity
FPL04_02630	COG0439	Biotin carboxylase
FPL04_02640	COG0511	ligase activity, forming carbon-carbon bonds
FPL04_02645	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FPL04_02655	COG1324	tolerance protein
FPL04_02660	COG2356	endonuclease I
FPL04_02665	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FPL04_02675	COG4771	TonB-dependent receptor
FPL04_02685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FPL04_02710	COG3712	iron ion homeostasis
FPL04_02735	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FPL04_02760	COG0778	Nitroreductase
FPL04_02765	COG2353	YceI-like domain
FPL04_02785	COG3052	prosthetic group binding
FPL04_02805	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
FPL04_02820	COG1802	Transcriptional regulator
FPL04_02825	COG0546	phosphoglycolate phosphatase activity
FPL04_02995	COG2207	Transcriptional regulator
FPL04_03000	COG0300	oxidoreductase activity
FPL04_03010	COG1595	DNA-templated transcription, initiation
FPL04_03065	COG0435	Glutathione S-transferase
FPL04_03100	COG1506	peptidase
FPL04_03100	COG0823	Involved in the tonB-independent uptake of proteins
FPL04_03115	COG3706	GGDEF domain
FPL04_03150	COG0697	spore germination
FPL04_03165	COG4305	rare lipoprotein A
FPL04_03170	COG1113	amino acid transport
FPL04_03175	COG0598	Magnesium transport protein CorA
FPL04_03190	COG3507	Belongs to the glycosyl hydrolase 43 family
FPL04_03245	COG0840	transmembrane signaling receptor activity
FPL04_03250	COG5297	Belongs to the glycosyl hydrolase family 6
FPL04_03250	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL04_03255	COG0659	secondary active sulfate transmembrane transporter activity
FPL04_03260	COG3706	GGDEF domain
FPL04_03275	COG2943	transferase activity, transferring hexosyl groups
FPL04_03285	COG3275	phosphorelay sensor kinase activity
FPL04_03295	COG0181	hydroxymethylbilane synthase activity
FPL04_03320	COG1505	serine-type exopeptidase activity
FPL04_03340	COG2832	Protein of unknown function (DUF454)
FPL04_03350	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FPL04_03365	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FPL04_03400	COG2226	methyltransferase
FPL04_03405	COG3300	MHYT domain
FPL04_03405	COG5001	Diguanylate cyclase
FPL04_03410	COG0308	aminopeptidase N
FPL04_03465	COG3284	Transcriptional regulator
FPL04_03475	COG1077	Cell shape determining protein MreB Mrl
FPL04_03480	COG1792	Involved in formation and maintenance of cell shape
FPL04_03495	COG0772	Belongs to the SEDS family
FPL04_03510	COG2951	lytic endotransglycosylase activity
FPL04_03515	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FPL04_03520	COG1686	Belongs to the peptidase S11 family
FPL04_03535	COG0321	lipoyl(octanoyl) transferase activity
FPL04_03540	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FPL04_03565	COG1056	cytidyltransferase-related domain
FPL04_03565	COG1051	belongs to the nudix hydrolase family
FPL04_03600	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FPL04_03605	COG0673	inositol 2-dehydrogenase activity
FPL04_03610	COG2823	Periplasmic or secreted lipoprotein
FPL04_03615	COG4251	negative regulation of phosphorylation
FPL04_03620	COG0784	Response regulator, receiver
FPL04_03625	COG4191	Histidine kinase
FPL04_03630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FPL04_03635	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_03685	COG1459	type II secretion system
FPL04_03700	COG2165	general secretion pathway protein
FPL04_03710	COG3156	type II secretion system protein K
FPL04_03735	COG3250	beta-galactosidase activity
FPL04_03760	COG1609	Transcriptional regulator
FPL04_03765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FPL04_03770	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FPL04_03785	COG0617	tRNA 3'-terminal CCA addition
FPL04_03805	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FPL04_03810	COG1012	belongs to the aldehyde dehydrogenase family
FPL04_03815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FPL04_03825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FPL04_03840	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FPL04_03845	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FPL04_03860	COG2205	protein histidine kinase activity
FPL04_03865	COG0745	RESPONSE REGULATOR receiver
FPL04_03890	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FPL04_03895	COG3791	Glutathione-dependent formaldehyde-activating
FPL04_03905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FPL04_03915	COG0697	spore germination
FPL04_03935	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FPL04_03940	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FPL04_03950	COG2205	protein histidine kinase activity
FPL04_03955	COG0745	RESPONSE REGULATOR receiver
FPL04_03960	COG0277	FAD linked oxidase domain protein
FPL04_03965	COG1988	membrane-bound metal-dependent
FPL04_04000	COG0275	rRNA processing
FPL04_04005	COG3116	cell division
FPL04_04015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FPL04_04020	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FPL04_04025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FPL04_04040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FPL04_04045	COG1181	Belongs to the D-alanine--D-alanine ligase family
FPL04_04050	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FPL04_04075	COG0739	heme binding
FPL04_04080	COG0653	protein targeting
FPL04_04090	COG0494	nUDIX hydrolase
FPL04_04105	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FPL04_04110	COG0604	alcohol dehydrogenase
FPL04_04110	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_04110	COG3321	synthase
FPL04_04120	COG0366	Alpha amylase catalytic
FPL04_04155	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FPL04_04175	COG2885	chlorophyll binding
FPL04_04195	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FPL04_04210	COG4106	trans-aconitate 2-methyltransferase activity
FPL04_04215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FPL04_04225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FPL04_04235	COG0667	Aldo Keto reductase
FPL04_04250	COG4771	TonB-dependent receptor
FPL04_04270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL04_04275	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FPL04_04285	COG2175	clavaminate synthase activity
FPL04_04295	COG4181	ATPase activity
FPL04_04310	COG0642	Histidine kinase
FPL04_04320	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FPL04_04340	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FPL04_04345	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FPL04_04355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FPL04_04360	COG2967	ApaG domain
FPL04_04370	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FPL04_04385	COG0123	including yeast histone deacetylase and acetoin utilization protein
FPL04_04390	COG2096	Adenosyltransferase
FPL04_04400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL04_04405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL04_04435	COG3384	dioxygenase
FPL04_04440	COG0583	DNA-binding transcription factor activity
FPL04_04445	COG0318	PFAM AMP-dependent synthetase and ligase
FPL04_04455	COG1024	Enoyl-CoA hydratase
FPL04_04505	COG0697	spore germination
FPL04_04510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FPL04_04525	COG3706	GGDEF domain
FPL04_04525	COG0745	RESPONSE REGULATOR receiver
FPL04_04535	COG2197	response regulator
FPL04_04545	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FPL04_04555	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FPL04_04560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FPL04_04565	COG0583	DNA-binding transcription factor activity
FPL04_04570	COG3634	alkyl hydroperoxide reductase activity
FPL04_04580	COG2890	protein-(glutamine-N5) methyltransferase activity
FPL04_04600	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FPL04_04600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FPL04_04630	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FPL04_04650	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FPL04_04655	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FPL04_04675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FPL04_04680	COG1404	Belongs to the peptidase S8 family
FPL04_04685	COG1404	Belongs to the peptidase S8 family
FPL04_04690	COG1404	Belongs to the peptidase S8 family
FPL04_04695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FPL04_04715	COG1295	ribonuclease BN
FPL04_04720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FPL04_04725	COG1254	Belongs to the acylphosphatase family
FPL04_04740	COG0521	Mo-molybdopterin cofactor biosynthetic process
FPL04_04755	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FPL04_04765	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FPL04_04780	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FPL04_04785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FPL04_04790	COG0193	aminoacyl-tRNA hydrolase activity
FPL04_04795	COG0012	GTP binding
FPL04_04815	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FPL04_04825	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FPL04_04830	COG0250	Participates in transcription elongation, termination and antitermination
FPL04_04835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FPL04_04840	COG0081	regulation of translation
FPL04_04845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FPL04_04850	COG0222	ribosome binding
FPL04_04860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FPL04_04865	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FPL04_04875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FPL04_04880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FPL04_04885	COG0051	transcription antitermination factor activity, RNA binding
FPL04_04905	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FPL04_04930	COG0255	Belongs to the universal ribosomal protein uL29 family
FPL04_04940	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FPL04_04945	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FPL04_04955	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FPL04_04965	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FPL04_04975	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FPL04_04980	COG1841	ribosomal large subunit assembly
FPL04_04990	COG0201	protein transport
FPL04_04995	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FPL04_05000	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FPL04_05005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FPL04_05010	COG0202	RNA polymerase activity
FPL04_05015	COG0203	ribosomal protein L17
FPL04_05025	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FPL04_05035	COG0154	amidase activity
FPL04_05050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FPL04_05060	COG0625	glutathione transferase activity
FPL04_05075	COG0446	pyridine nucleotide-disulphide oxidoreductase
FPL04_05075	COG1902	pentaerythritol trinitrate reductase activity
FPL04_05080	COG0604	alcohol dehydrogenase
FPL04_05090	COG2885	chlorophyll binding
FPL04_05115	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FPL04_05120	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FPL04_05125	COG4208	sulfate ABC transporter
FPL04_05130	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FPL04_05140	COG1063	alcohol dehydrogenase
FPL04_05155	COG0406	alpha-ribazole phosphatase activity
FPL04_05165	COG0285	dihydrofolate synthase activity
FPL04_05185	COG2833	Protein of unknown function (DUF455)
FPL04_05190	COG3291	Pkd domain containing protein
FPL04_05200	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL04_05205	COG0671	phosphoesterase, PA-phosphatase related
FPL04_05210	COG0438	transferase activity, transferring glycosyl groups
FPL04_05220	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FPL04_05235	COG4783	chaperone-mediated protein folding
FPL04_05250	COG0473	3-isopropylmalate dehydrogenase activity
FPL04_05285	COG4191	Histidine kinase
FPL04_05285	COG0784	Response regulator, receiver
FPL04_05295	COG0544	peptidyl-prolyl cis-trans isomerase activity
FPL04_05300	COG0740	serine-type endopeptidase activity
FPL04_05305	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FPL04_05335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FPL04_05345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL04_05360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FPL04_05370	COG0631	protein serine/threonine phosphatase activity
FPL04_05385	COG0859	PFAM glycosyl transferase family 9
FPL04_05395	COG1234	tRNA 3'-trailer cleavage
FPL04_05400	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FPL04_05410	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FPL04_05415	COG0314	molybdopterin synthase activity
FPL04_05435	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FPL04_05440	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FPL04_05445	COG0537	adenosine 5'-monophosphoramidase activity
FPL04_05465	COG0714	Associated with various cellular activities
FPL04_05485	COG0424	maF-like protein
FPL04_05490	COG1399	metal-binding, possibly nucleic acid-binding protein
FPL04_05495	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FPL04_05500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL04_05510	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FPL04_05515	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_05520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FPL04_05530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FPL04_05535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FPL04_05570	COG0740	serine-type endopeptidase activity
FPL04_05605	COG0582	viral genome integration into host DNA
FPL04_05615	COG3829	transcription factor binding
FPL04_05655	COG2373	Large extracellular alpha-helical protein
FPL04_05685	COG4953	penicillin-binding protein 1C
FPL04_05695	COG0678	peroxiredoxin activity
FPL04_05715	COG0330	HflC and HflK could
FPL04_05720	COG0330	HflC and HflK could
FPL04_05740	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FPL04_05745	COG0308	aminopeptidase N
FPL04_05770	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_05775	COG1309	transcriptional regulator
FPL04_05810	COG1111	helicase
FPL04_05810	COG1205	dead DEAH box helicase
FPL04_05815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FPL04_05885	COG1309	transcriptional regulator
FPL04_05890	COG0328	RNA-DNA hybrid ribonuclease activity
FPL04_05890	COG0406	alpha-ribazole phosphatase activity
FPL04_05895	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FPL04_05910	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_05920	COG3537	Alpha-1,2-mannosidase
FPL04_05960	COG2323	membrane
FPL04_05975	COG2271	Major facilitator Superfamily
FPL04_06000	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FPL04_06005	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FPL04_06010	COG2080	2 iron, 2 sulfur cluster binding
FPL04_06055	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FPL04_06070	COG0587	DNA-directed DNA polymerase activity
FPL04_06090	COG1297	OPT oligopeptide transporter protein
FPL04_06110	COG0823	Involved in the tonB-independent uptake of proteins
FPL04_06110	COG1506	peptidase
FPL04_06125	COG1917	Cupin 2, conserved barrel domain protein
FPL04_06125	COG2207	Transcriptional regulator
FPL04_06135	COG0753	catalase activity
FPL04_06140	COG0656	L-ascorbic acid biosynthetic process
FPL04_06145	COG2272	Belongs to the type-B carboxylesterase lipase family
FPL04_06150	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FPL04_06150	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FPL04_06155	COG2814	Major facilitator Superfamily
FPL04_06175	COG2194	sulfuric ester hydrolase activity
FPL04_06185	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FPL04_06190	COG0745	RESPONSE REGULATOR receiver
FPL04_06195	COG5002	protein histidine kinase activity
FPL04_06205	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FPL04_06210	COG2894	cell division
FPL04_06215	COG0850	regulation of cytokinetic process
FPL04_06230	COG4585	Histidine kinase
FPL04_06235	COG2197	response regulator
FPL04_06250	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FPL04_06285	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FPL04_06295	COG1595	DNA-templated transcription, initiation
FPL04_06305	COG1946	Acyl-CoA thioesterase
FPL04_06310	COG1024	Enoyl-CoA hydratase
FPL04_06320	COG0824	Thioesterase
FPL04_06325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FPL04_06335	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FPL04_06355	COG0196	riboflavin kinase activity
FPL04_06365	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FPL04_06370	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FPL04_06385	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FPL04_06390	COG1845	cytochrome c oxidase, subunit III
FPL04_06395	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FPL04_06410	COG3152	Membrane
FPL04_06420	COG2207	Transcriptional regulator
FPL04_06425	COG0326	Molecular chaperone. Has ATPase activity
FPL04_06445	COG1902	pentaerythritol trinitrate reductase activity
FPL04_06450	COG1366	Belongs to the anti-sigma-factor antagonist family
FPL04_06455	COG1366	Belongs to the anti-sigma-factor antagonist family
FPL04_06460	COG2172	sigma factor antagonist activity
FPL04_06490	COG4771	TonB-dependent receptor
FPL04_06500	COG5507	3-demethylubiquinone-9 3-methyltransferase
FPL04_06505	COG2205	protein histidine kinase activity
FPL04_06515	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FPL04_06520	COG2205	protein histidine kinase activity
FPL04_06520	COG3437	response regulator, receiver
FPL04_06520	COG3850	Histidine kinase
FPL04_06520	COG4999	Histidine kinase
FPL04_06525	COG0784	Response regulator, receiver
FPL04_06525	COG4191	Histidine kinase
FPL04_06555	COG3534	alpha-L-arabinofuranosidase
FPL04_06570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FPL04_06575	COG2070	2-Nitropropane dioxygenase
FPL04_06595	COG0336	Belongs to the RNA methyltransferase TrmD family
FPL04_06605	COG0534	Mate efflux family protein
FPL04_06615	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FPL04_06630	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FPL04_06650	COG3250	beta-galactosidase activity
FPL04_06655	COG3867	Arabinogalactan endo-beta-1,4-galactanase
FPL04_06665	COG1396	sequence-specific DNA binding
FPL04_06665	COG3800	Transcriptional regulator
FPL04_06675	COG1960	acyl-CoA dehydrogenase activity
FPL04_06720	COG0457	Tetratricopeptide repeat
FPL04_06730	COG1250	3-hydroxyacyl-CoA dehydrogenase
FPL04_06730	COG1024	Enoyl-CoA hydratase
FPL04_06745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FPL04_06765	COG0571	ribonuclease III activity
FPL04_06770	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FPL04_06775	COG1381	Involved in DNA repair and RecF pathway recombination
FPL04_06795	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FPL04_06800	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
FPL04_06805	COG3046	protein related to deoxyribodipyrimidine photolyase
FPL04_06810	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL04_06820	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FPL04_06825	COG1278	Cold shock
FPL04_06830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL04_06840	COG1201	RNA secondary structure unwinding
FPL04_06845	COG1793	dna ligase
FPL04_06855	COG1793	dna ligase
FPL04_06855	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FPL04_06870	COG0745	RESPONSE REGULATOR receiver
FPL04_06870	COG3706	GGDEF domain
FPL04_06890	COG0183	Belongs to the thiolase family
FPL04_06910	COG1451	nucleotide metabolic process
FPL04_06915	COG5487	UPF0391 membrane protein
FPL04_06925	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FPL04_06970	COG1047	Peptidyl-prolyl cis-trans
FPL04_06980	COG2824	Alkylphosphonate utilization operon protein PhnA
FPL04_07000	COG1902	pentaerythritol trinitrate reductase activity
FPL04_07005	COG2814	Major facilitator Superfamily
FPL04_07040	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FPL04_07040	COG0392	lysyltransferase activity
FPL04_07050	COG0251	oxidation-reduction process
FPL04_07055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FPL04_07070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FPL04_07095	COG1595	DNA-templated transcription, initiation
FPL04_07110	COG2878	Part of a membrane complex involved in electron transport
FPL04_07120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FPL04_07120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FPL04_07135	COG1131	(ABC) transporter
FPL04_07140	COG0346	lactoylglutathione lyase activity
FPL04_07145	COG0833	amino acid
FPL04_07150	COG2040	homocysteine
FPL04_07170	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FPL04_07190	COG1695	Transcriptional regulator
FPL04_07240	COG0825	malonyl-CoA metabolic process
FPL04_07255	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL04_07260	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL04_07270	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL04_07285	COG0750	zinc metalloprotease
FPL04_07290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FPL04_07295	COG0575	Belongs to the CDS family
FPL04_07310	COG0528	UMP kinase activity
FPL04_07315	COG0745	RESPONSE REGULATOR receiver
FPL04_07315	COG3706	GGDEF domain
FPL04_07320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FPL04_07325	COG0052	Belongs to the universal ribosomal protein uS2 family
FPL04_07360	COG0024	Methionine aminopeptidase
FPL04_07380	COG1393	Belongs to the ArsC family
FPL04_07385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FPL04_07395	COG0367	asparagine synthase
FPL04_07405	COG4774	siderophore transport
FPL04_07445	COG1566	PFAM secretion protein HlyD family protein
FPL04_07450	COG2814	Major facilitator Superfamily
FPL04_07460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FPL04_07515	COG0339	signal peptide processing
FPL04_07525	COG0386	Belongs to the glutathione peroxidase family
FPL04_07550	COG0288	reversible hydration of carbon dioxide
FPL04_07560	COG2839	Protein conserved in bacteria
FPL04_07580	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FPL04_07585	COG0084	hydrolase, TatD family'
FPL04_07600	COG1960	acyl-CoA dehydrogenase activity
FPL04_07615	COG0367	asparagine synthase
FPL04_07625	COG0305	Participates in initiation and elongation during chromosome replication
FPL04_07630	COG0415	Belongs to the DNA photolyase family
FPL04_07645	COG0583	DNA-binding transcription factor activity
FPL04_07660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL04_07680	COG3706	GGDEF domain
FPL04_07690	COG3706	GGDEF domain
FPL04_07710	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FPL04_07725	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL04_07735	COG0497	DNA recombination
FPL04_07740	COG1420	regulation of RNA biosynthetic process
FPL04_07745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FPL04_07750	COG0443	Heat shock 70 kDa protein
FPL04_07755	COG0484	heat shock protein binding
FPL04_07760	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FPL04_07765	COG0287	Prephenate dehydrogenase
FPL04_07765	COG1605	Chorismate mutase
FPL04_07785	COG2274	protein secretion by the type I secretion system
FPL04_07790	COG0583	DNA-binding transcription factor activity
FPL04_07795	COG1132	(ABC) transporter
FPL04_07830	COG2850	peptidyl-arginine hydroxylation
FPL04_07845	COG1253	flavin adenine dinucleotide binding
FPL04_07875	COG1131	(ABC) transporter
FPL04_07880	COG1725	Transcriptional regulator
FPL04_07890	COG0386	Belongs to the glutathione peroxidase family
FPL04_07935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FPL04_07945	COG1410	methionine synthase
FPL04_07945	COG0646	methionine synthase
FPL04_07950	COG0646	methionine synthase
FPL04_07950	COG1410	methionine synthase
FPL04_07960	COG1960	acyl-CoA dehydrogenase activity
FPL04_07980	COG0557	exoribonuclease II activity
FPL04_07990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FPL04_08000	COG3706	GGDEF domain
FPL04_08005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FPL04_08015	COG0704	Plays a role in the regulation of phosphate uptake
FPL04_08020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FPL04_08025	COG0581	inorganic phosphate transmembrane transporter activity
FPL04_08030	COG0573	inorganic phosphate transmembrane transporter activity
FPL04_08035	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FPL04_08060	COG0659	secondary active sulfate transmembrane transporter activity
FPL04_08065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FPL04_08075	COG1024	Enoyl-CoA hydratase
FPL04_08085	COG0494	nUDIX hydrolase
FPL04_08135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FPL04_08160	COG2925	Exonuclease
FPL04_08165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL04_08170	COG3844	kynureninase activity
FPL04_08180	COG0662	Cupin 2, conserved barrel domain protein
FPL04_08185	COG0288	reversible hydration of carbon dioxide
FPL04_08210	COG0017	Asparaginyl-tRNA synthetase
FPL04_08220	COG0316	Belongs to the HesB IscA family
FPL04_08245	COG3115	cell septum assembly
FPL04_08255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FPL04_08260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FPL04_08265	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FPL04_08280	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FPL04_08290	COG4993	Dehydrogenase
FPL04_08305	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FPL04_08315	COG2986	histidine ammonia-lyase
FPL04_08355	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FPL04_08360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FPL04_08365	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FPL04_08370	COG1605	Chorismate mutase
FPL04_08370	COG0077	Prephenate dehydratase
FPL04_08375	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FPL04_08390	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FPL04_08395	COG0583	DNA-binding transcription factor activity
FPL04_08415	COG0840	transmembrane signaling receptor activity
FPL04_08450	COG0840	transmembrane signaling receptor activity
FPL04_08470	COG0784	Response regulator, receiver
FPL04_08470	COG4191	Histidine kinase
FPL04_08475	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
FPL04_08480	COG0784	Response regulator, receiver
FPL04_08480	COG4191	Histidine kinase
FPL04_08495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FPL04_08505	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FPL04_08515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FPL04_08520	COG1404	Belongs to the peptidase S8 family
FPL04_08530	COG1595	DNA-templated transcription, initiation
FPL04_08580	COG2244	polysaccharide biosynthetic process
FPL04_08610	COG2264	protein methyltransferase activity
FPL04_08615	COG0438	transferase activity, transferring glycosyl groups
FPL04_08620	COG0438	transferase activity, transferring glycosyl groups
FPL04_08635	COG1136	(ABC) transporter
FPL04_08640	COG1132	(ABC) transporter
FPL04_08645	COG0477	Major facilitator Superfamily
FPL04_08650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FPL04_08665	COG1253	flavin adenine dinucleotide binding
FPL04_08720	COG0148	phosphopyruvate hydratase activity
FPL04_08745	COG2840	Smr protein MutS2
FPL04_08750	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FPL04_08755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FPL04_08760	COG1238	metal cluster binding
FPL04_08775	COG1534	Rna-binding protein
FPL04_08780	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FPL04_08785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FPL04_08790	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FPL04_08795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FPL04_08800	COG1923	regulation of RNA biosynthetic process
FPL04_08805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FPL04_08810	COG1546	Belongs to the CinA family
FPL04_08820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FPL04_08825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FPL04_08830	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FPL04_08835	COG2137	regulation of response to DNA damage stimulus
FPL04_08840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FPL04_08845	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FPL04_09030	COG3179	chitinase
FPL04_09120	COG1196	nuclear chromosome segregation
FPL04_09195	COG2944	sequence-specific DNA binding
FPL04_09215	COG0582	viral genome integration into host DNA
FPL04_09225	COG1741	Belongs to the pirin family
FPL04_09230	COG0583	DNA-binding transcription factor activity
FPL04_09255	COG0351	phosphomethylpyrimidine kinase
FPL04_09255	COG0352	thiamine-phosphate diphosphorylase activity
FPL04_09270	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FPL04_09275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FPL04_09290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FPL04_09300	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FPL04_09305	COG3734	2-keto-3-deoxy-galactonokinase
FPL04_09320	COG0800	Aldolase
FPL04_09360	COG1501	Belongs to the glycosyl hydrolase 31 family
FPL04_09370	COG1070	Carbohydrate kinase
FPL04_09375	COG2115	Belongs to the xylose isomerase family
FPL04_09380	COG0477	Major facilitator Superfamily
FPL04_09400	COG0860	N-Acetylmuramoyl-L-alanine amidase
FPL04_09425	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FPL04_09430	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FPL04_09465	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL04_09480	COG5001	Diguanylate cyclase
FPL04_09480	COG4251	negative regulation of phosphorylation
FPL04_09480	COG2203	Gaf domain
FPL04_09480	COG3706	GGDEF domain
FPL04_09485	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FPL04_09495	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FPL04_09505	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FPL04_09510	COG0671	phosphoesterase, PA-phosphatase related
FPL04_09520	COG1794	racemase activity, acting on amino acids and derivatives
FPL04_09530	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FPL04_09550	COG1012	belongs to the aldehyde dehydrogenase family
FPL04_09570	COG1215	transferase activity, transferring glycosyl groups
FPL04_09575	COG0726	polysaccharide deacetylase
FPL04_09575	COG1649	PFAM Uncharacterised BCR, COG1649
FPL04_09655	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FPL04_09685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FPL04_09690	COG0124	histidyl-tRNA synthetase
FPL04_09705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FPL04_09710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FPL04_09715	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FPL04_09715	COG0131	Imidazoleglycerol-phosphate dehydratase
FPL04_09720	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FPL04_09725	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FPL04_09730	COG0107	imidazoleglycerol-phosphate synthase activity
FPL04_09735	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FPL04_09735	COG0140	phosphoribosyl-ATP diphosphatase activity
FPL04_09750	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
FPL04_09770	COG0531	amino acid
FPL04_09775	COG0531	amino acid
FPL04_09790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FPL04_09795	COG0277	FAD linked oxidase domain protein
FPL04_09815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FPL04_09855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FPL04_09860	COG2258	MOSC domain
FPL04_09870	COG0505	Belongs to the CarA family
FPL04_09880	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FPL04_09885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FPL04_09895	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FPL04_09915	COG3279	Response regulator of the LytR AlgR family
FPL04_09925	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FPL04_09935	COG0784	Response regulator, receiver
FPL04_09935	COG2205	protein histidine kinase activity
FPL04_09935	COG2198	Histidine kinase
FPL04_09940	COG1024	Enoyl-CoA hydratase
FPL04_09945	COG0318	PFAM AMP-dependent synthetase and ligase
FPL04_09975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL04_09985	COG2201	protein-glutamate methylesterase activity
FPL04_10000	COG0840	transmembrane signaling receptor activity
FPL04_10010	COG0835	chemotaxis
FPL04_10030	COG0840	transmembrane signaling receptor activity
FPL04_10035	COG0840	transmembrane signaling receptor activity
FPL04_10040	COG0840	transmembrane signaling receptor activity
FPL04_10045	COG0840	transmembrane signaling receptor activity
FPL04_10050	COG0840	transmembrane signaling receptor activity
FPL04_10070	COG0840	transmembrane signaling receptor activity
FPL04_10090	COG0745	RESPONSE REGULATOR receiver
FPL04_10100	COG0835	chemotaxis
FPL04_10105	COG1192	Involved in chromosome partitioning
FPL04_10110	COG1360	Flagellar Motor Protein
FPL04_10115	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FPL04_10185	COG0643	Histidine kinase
FPL04_10185	COG2198	Histidine kinase
FPL04_10205	COG0455	bacterial-type flagellum organization
FPL04_10240	COG3300	MHYT domain
FPL04_10240	COG5001	Diguanylate cyclase
FPL04_10245	COG1684	flagellar biosynthetic protein fliR
FPL04_10250	COG1987	bacterial-type flagellum assembly
FPL04_10260	COG3190	flagellar
FPL04_10310	COG1677	Flagellar hook-basal body complex protein FliE
FPL04_10365	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_10375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL04_10390	COG2204	response regulator
FPL04_10395	COG2201	protein-glutamate methylesterase activity
FPL04_10425	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FPL04_10430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FPL04_10445	COG1705	Flagellar rod assembly protein muramidase FlgJ
FPL04_10445	COG3951	Flagellar rod assembly protein muramidase FlgJ
FPL04_10450	COG1706	bacterial-type flagellum-dependent cell motility
FPL04_10455	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FPL04_10460	COG4786	Flagellar basal body rod
FPL04_10470	COG4787	bacterial-type flagellum-dependent cell motility
FPL04_10475	COG1749	Flagellar hook protein flgE
FPL04_10480	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FPL04_10485	COG1558	bacterial-type flagellum-dependent cell motility
FPL04_10490	COG1815	bacterial-type flagellum-dependent cell motility
FPL04_10495	COG0784	Response regulator, receiver
FPL04_10495	COG0835	chemotaxis
FPL04_10515	COG4191	Histidine kinase
FPL04_10545	COG2915	High frequency lysogenization protein hflD homolog
FPL04_10550	COG0482	sulfurtransferase activity
FPL04_10565	COG0542	response to heat
FPL04_10570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FPL04_10575	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FPL04_10585	COG0492	ferredoxin-NADP+ reductase activity
FPL04_10590	COG1674	ftsk spoiiie
FPL04_10605	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FPL04_10610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FPL04_10615	COG0183	Belongs to the thiolase family
FPL04_10620	COG1250	3-hydroxyacyl-CoA dehydrogenase
FPL04_10620	COG1024	Enoyl-CoA hydratase
FPL04_10630	COG0105	UTP biosynthetic process
FPL04_10635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FPL04_10645	COG1426	Protein conserved in bacteria
FPL04_10655	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL04_10660	COG1160	GTP binding
FPL04_10665	COG0303	'Molybdopterin
FPL04_10670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FPL04_10695	COG0708	Exodeoxyribonuclease III
FPL04_10705	COG0303	'Molybdopterin
FPL04_10710	COG0746	molybdenum cofactor guanylyltransferase activity
FPL04_10720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FPL04_10720	COG1648	precorrin-2 dehydrogenase activity
FPL04_10730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FPL04_10735	COG2223	nitrite transmembrane transporter activity
FPL04_10740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FPL04_10750	COG0243	molybdopterin cofactor binding
FPL04_10775	COG5001	Diguanylate cyclase
FPL04_10820	COG4191	Histidine kinase
FPL04_10820	COG0784	Response regulator, receiver
FPL04_10870	COG0840	transmembrane signaling receptor activity
FPL04_10900	COG3781	membrane
FPL04_10910	COG2197	response regulator
FPL04_10925	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_11025	COG0859	PFAM glycosyl transferase family 9
FPL04_11050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL04_11070	COG4106	trans-aconitate 2-methyltransferase activity
FPL04_11080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL04_11080	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
FPL04_11110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL04_11115	COG2192	nodulation
FPL04_11125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL04_11145	COG0367	asparagine synthase
FPL04_11155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL04_11160	COG0577	efflux transmembrane transporter activity
FPL04_11160	COG1136	(ABC) transporter
FPL04_11165	COG1136	(ABC) transporter
FPL04_11165	COG0577	efflux transmembrane transporter activity
FPL04_11170	COG1136	(ABC) transporter
FPL04_11170	COG0577	efflux transmembrane transporter activity
FPL04_11175	COG3321	synthase
FPL04_11175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FPL04_11175	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_11175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FPL04_11175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL04_11190	COG0300	oxidoreductase activity
FPL04_11190	COG0318	PFAM AMP-dependent synthetase and ligase
FPL04_11190	COG3321	synthase
FPL04_11190	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_11190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL04_11225	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FPL04_11250	COG3459	Glycosyltransferase 36 associated
FPL04_11490	COG2154	pterin-4-alpha-carbinolamine dehydratase
FPL04_11500	COG0428	transporter
FPL04_11515	COG1530	ribonuclease E activity
FPL04_11545	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FPL04_11570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FPL04_11575	COG0322	excinuclease ABC activity
FPL04_11585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FPL04_11590	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FPL04_11595	COG1663	tetraacyldisaccharide 4'-kinase activity
FPL04_11600	COG1132	(ABC) transporter
FPL04_11610	COG0811	peptide transport
FPL04_11630	COG4591	ABC-type transport system involved in lipoprotein release permease component
FPL04_11640	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FPL04_11645	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FPL04_11660	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FPL04_11665	COG2009	succinate dehydrogenase
FPL04_11685	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FPL04_11690	COG0837	glucose binding
FPL04_11700	COG0129	dihydroxy-acid dehydratase activity
FPL04_11705	COG0800	Aldolase
FPL04_11770	COG0784	Response regulator, receiver
FPL04_11770	COG2205	protein histidine kinase activity
FPL04_11770	COG5002	protein histidine kinase activity
FPL04_11775	COG2183	response to ionizing radiation
FPL04_11785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL04_11785	COG0723	plastoquinol--plastocyanin reductase activity
FPL04_11800	COG3243	poly(R)-hydroxyalkanoic acid synthase
FPL04_11810	COG1183	phosphatidylcholine synthase activity
FPL04_11815	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_11840	COG0668	transmembrane transport
FPL04_11845	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FPL04_11850	COG0590	tRNA wobble adenosine to inosine editing
FPL04_11855	COG1321	iron dependent repressor
FPL04_11860	COG1914	H( )-stimulated, divalent metal cation uptake system
FPL04_11870	COG2814	Major facilitator Superfamily
FPL04_11885	COG1335	isochorismatase
FPL04_11900	COG2197	response regulator
FPL04_11920	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_11935	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FPL04_11945	COG0475	glutathione-regulated potassium exporter activity
FPL04_11945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FPL04_11950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FPL04_11960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FPL04_11965	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FPL04_11980	COG0539	negative regulation of cytoplasmic translation
FPL04_11985	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FPL04_11990	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FPL04_12000	COG2957	Belongs to the agmatine deiminase family
FPL04_12005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FPL04_12030	COG0395	ABC-type sugar transport system, permease component
FPL04_12035	COG1175	transmembrane transport
FPL04_12040	COG1653	transport
FPL04_12065	COG2350	Protein conserved in bacteria
FPL04_12070	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FPL04_12075	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FPL04_12080	COG1187	pseudouridine synthase activity
FPL04_12100	COG0436	Aminotransferase
FPL04_12105	COG4133	protoheme IX ABC transporter activity
FPL04_12125	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FPL04_12150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL04_12160	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FPL04_12165	COG4988	ABC transporter
FPL04_12175	COG1294	oxidase, subunit
FPL04_12220	COG0165	Argininosuccinate lyase
FPL04_12235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FPL04_12245	COG0137	argininosuccinate synthase activity
FPL04_12250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FPL04_12265	COG0215	cysteine-tRNA ligase activity
FPL04_12275	COG2166	iron-sulfur cluster assembly
FPL04_12285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FPL04_12295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FPL04_12310	COG4303	Ethanolamine ammonia lyase large subunit
FPL04_12315	COG4302	ethanolamine ammonia-lyase activity
FPL04_12330	COG4677	pectinesterase activity
FPL04_12350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FPL04_12355	COG0402	S-adenosylhomocysteine deaminase activity
FPL04_12365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FPL04_12375	COG3300	MHYT domain
FPL04_12375	COG5001	Diguanylate cyclase
FPL04_12390	COG0483	inositol monophosphate 1-phosphatase activity
FPL04_12415	COG0513	Belongs to the DEAD box helicase family
FPL04_12420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FPL04_12425	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FPL04_12435	COG0625	glutathione transferase activity
FPL04_12450	COG4681	YaeQ
FPL04_12455	COG2081	HI0933 family
FPL04_12470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FPL04_12475	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_12495	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FPL04_12500	COG0860	N-Acetylmuramoyl-L-alanine amidase
FPL04_12510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FPL04_12510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FPL04_12515	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FPL04_12530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FPL04_12560	COG0835	chemotaxis
FPL04_12565	COG0840	transmembrane signaling receptor activity
FPL04_12570	COG2094	Belongs to the DNA glycosylase MPG family
FPL04_12575	COG1201	RNA secondary structure unwinding
FPL04_12585	COG2969	positive regulation of protein catabolic process
FPL04_12590	COG0625	glutathione transferase activity
FPL04_12595	COG2857	Cytochrome c1
FPL04_12600	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FPL04_12605	COG0723	plastoquinol--plastocyanin reductase activity
FPL04_12610	COG0741	lytic transglycosylase activity
FPL04_12625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FPL04_12630	COG1702	phosphate starvation-inducible protein PhoH
FPL04_12640	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FPL04_12650	COG4535	Mg2 and Co2 transporter CorC
FPL04_12665	COG1012	belongs to the aldehyde dehydrogenase family
FPL04_12675	COG1177	transmembrane transport
FPL04_12680	COG1176	ABC-type spermidine putrescine transport system, permease component I
FPL04_12685	COG3842	ATPase activity
FPL04_12705	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FPL04_12720	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FPL04_12725	COG0174	glutamine synthetase
FPL04_12730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL04_12735	COG3706	GGDEF domain
FPL04_12735	COG0745	RESPONSE REGULATOR receiver
FPL04_12740	COG2703	oxygen carrier activity
FPL04_12745	COG0477	Major facilitator Superfamily
FPL04_12750	COG0745	RESPONSE REGULATOR receiver
FPL04_12750	COG3706	GGDEF domain
FPL04_12755	COG5002	protein histidine kinase activity
FPL04_12755	COG0784	Response regulator, receiver
FPL04_12755	COG2205	protein histidine kinase activity
FPL04_12765	COG0243	molybdopterin cofactor binding
FPL04_12790	COG2733	membrane
FPL04_12795	COG2205	protein histidine kinase activity
FPL04_12795	COG0784	Response regulator, receiver
FPL04_12795	COG5002	protein histidine kinase activity
FPL04_12805	COG0477	Major facilitator Superfamily
FPL04_12820	COG0300	oxidoreductase activity
FPL04_12830	COG1902	pentaerythritol trinitrate reductase activity
FPL04_12850	COG2902	Dehydrogenase
FPL04_12860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL04_12865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL04_12875	COG1609	Transcriptional regulator
FPL04_12880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FPL04_12880	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FPL04_12885	COG1105	Belongs to the carbohydrate kinase PfkB family
FPL04_12890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FPL04_12890	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FPL04_12900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FPL04_12910	COG1862	Preprotein translocase
FPL04_12955	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FPL04_12965	COG3291	Pkd domain containing protein
FPL04_12975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FPL04_12995	COG0742	ribosomal rna small subunit methyltransferase
FPL04_13000	COG0326	Molecular chaperone. Has ATPase activity
FPL04_13045	COG0531	amino acid
FPL04_13060	COG0006	proline dipeptidase activity
FPL04_13070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FPL04_13085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL04_13090	COG3938	Belongs to the proline racemase family
FPL04_13100	COG0552	protein localization to endoplasmic reticulum
FPL04_13120	COG4191	Histidine kinase
FPL04_13120	COG0784	Response regulator, receiver
FPL04_13130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FPL04_13155	COG1960	acyl-CoA dehydrogenase activity
FPL04_13165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FPL04_13190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL04_13195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FPL04_13230	COG0438	transferase activity, transferring glycosyl groups
FPL04_13235	COG0438	transferase activity, transferring glycosyl groups
FPL04_13280	COG0776	regulation of translation
FPL04_13285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FPL04_13285	COG0072	phenylalanine-tRNA ligase activity
FPL04_13290	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FPL04_13295	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FPL04_13300	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FPL04_13305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FPL04_13310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FPL04_13325	COG2211	Major facilitator Superfamily
FPL04_13335	COG1082	Xylose isomerase domain protein TIM barrel
FPL04_13350	COG0366	Alpha amylase catalytic
FPL04_13395	COG3702	type iv secretory pathway
FPL04_13415	COG2948	multi-organism process
FPL04_13435	COG3505	Type IV secretory pathway VirD4
FPL04_13450	COG0556	nucleotide-excision repair
FPL04_13495	COG3275	phosphorelay sensor kinase activity
FPL04_13500	COG1611	Belongs to the LOG family
FPL04_13510	COG2095	MarC family integral membrane protein
FPL04_13515	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_13520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FPL04_13525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FPL04_13560	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FPL04_13565	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FPL04_13570	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FPL04_13575	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FPL04_13580	COG0195	Participates in both transcription termination and antitermination
FPL04_13585	COG0779	Required for maturation of 30S ribosomal subunits
FPL04_13595	COG1007	ATP synthesis coupled electron transport
FPL04_13610	COG0713	ATP synthesis coupled electron transport
FPL04_13615	COG0839	Belongs to the complex I subunit 6 family
FPL04_13620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL04_13625	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FPL04_13630	COG1034	ATP synthesis coupled electron transport
FPL04_13635	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FPL04_13640	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FPL04_13650	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL04_13660	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL04_13680	COG4221	oxidoreductase activity
FPL04_13710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FPL04_13730	COG0133	tryptophan synthase activity
FPL04_13740	COG0135	phosphoribosylanthranilate isomerase activity
FPL04_13760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FPL04_13765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FPL04_13780	COG2890	protein-(glutamine-N5) methyltransferase activity
FPL04_13790	COG0688	phosphatidylethanolamine metabolic process
FPL04_13805	COG0433	COG0433 Predicted ATPase
FPL04_13810	COG0494	nUDIX hydrolase
FPL04_13830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FPL04_13860	COG0717	Belongs to the dCTP deaminase family
FPL04_13870	COG0489	protein tyrosine kinase activity
FPL04_13890	COG3590	peptidase
FPL04_13915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FPL04_13920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL04_13925	COG2311	Membrane
FPL04_13930	COG1047	Peptidyl-prolyl cis-trans
FPL04_13935	COG0791	NLP P60 protein
FPL04_13940	COG0791	NLP P60 protein
FPL04_13955	COG1301	dicarboxylic acid transport
FPL04_13960	COG1785	Belongs to the alkaline phosphatase family
FPL04_13965	COG0037	tRNA processing
FPL04_13970	COG1722	exodeoxyribonuclease VII activity
FPL04_13975	COG0142	geranyltranstransferase activity
FPL04_13980	COG4104	PAAR repeat-containing protein
FPL04_13990	COG0312	modulator of DNA gyrase
FPL04_14000	COG0312	modulator of DNA gyrase
FPL04_14010	COG3164	Protein of unknown function
FPL04_14015	COG1530	ribonuclease E activity
FPL04_14020	COG0424	maF-like protein
FPL04_14025	COG2968	Membrane
FPL04_14060	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FPL04_14075	COG0495	leucyl-tRNA aminoacylation
FPL04_14085	COG3118	belongs to the thioredoxin family
FPL04_14095	COG2155	Conserved Protein
FPL04_14145	COG1132	(ABC) transporter
FPL04_14175	COG0745	RESPONSE REGULATOR receiver
FPL04_14180	COG5002	protein histidine kinase activity
FPL04_14180	COG5000	phosphorelay sensor kinase activity
FPL04_14185	COG0475	glutathione-regulated potassium exporter activity
FPL04_14190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FPL04_14195	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FPL04_14210	COG3706	GGDEF domain
FPL04_14210	COG0745	RESPONSE REGULATOR receiver
FPL04_14215	COG1187	pseudouridine synthase activity
FPL04_14220	COG5002	protein histidine kinase activity
FPL04_14220	COG5001	Diguanylate cyclase
FPL04_14250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL04_14280	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FPL04_14335	COG0667	Aldo Keto reductase
FPL04_14340	COG2814	Major facilitator Superfamily
FPL04_14345	COG0583	DNA-binding transcription factor activity
FPL04_14365	COG2207	Transcriptional regulator
FPL04_14380	COG1309	transcriptional regulator
FPL04_14385	COG1538	Outer membrane efflux protein
FPL04_14390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL04_14405	COG0430	RNA-3'-phosphate cyclase activity
FPL04_14410	COG1690	Belongs to the RtcB family
FPL04_14420	COG4650	regulator
FPL04_14425	COG0735	belongs to the Fur family
FPL04_14430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FPL04_14455	COG4452	Inner membrane protein CreD
FPL04_14465	COG2205	protein histidine kinase activity
FPL04_14470	COG0745	RESPONSE REGULATOR receiver
FPL04_14475	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FPL04_14490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FPL04_14500	COG0643	Histidine kinase
FPL04_14500	COG2198	Histidine kinase
FPL04_14510	COG0840	transmembrane signaling receptor activity
FPL04_14515	COG0835	chemotaxis
FPL04_14520	COG2199	diguanylate cyclase activity
FPL04_14520	COG2200	EAL domain
FPL04_14520	COG2202	Pas domain
FPL04_14525	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FPL04_14535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL04_14540	COG3590	peptidase
FPL04_14550	COG0588	phosphoglycerate mutase activity
FPL04_14555	COG1515	deoxyribonuclease V activity
FPL04_14560	COG1741	Belongs to the pirin family
FPL04_14575	COG1741	Belongs to the pirin family
FPL04_14580	COG1966	Carbon starvation protein
FPL04_14585	COG2879	small protein
FPL04_14595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FPL04_14630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FPL04_14635	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FPL04_14640	COG2080	2 iron, 2 sulfur cluster binding
FPL04_14645	COG3321	synthase
FPL04_14645	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_14645	COG0604	alcohol dehydrogenase
FPL04_14650	COG5001	Diguanylate cyclase
FPL04_14650	COG4251	negative regulation of phosphorylation
FPL04_14650	COG3706	GGDEF domain
FPL04_14650	COG2203	Gaf domain
FPL04_14655	COG0629	single-stranded DNA binding
FPL04_14660	COG0142	geranyltranstransferase activity
FPL04_14670	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FPL04_14685	COG0527	aspartate kinase activity
FPL04_14690	COG0384	phenazine biosynthesis protein PhzF
FPL04_14695	COG0384	phenazine biosynthesis protein PhzF
FPL04_14705	COG1764	response to oxidative stress
FPL04_14710	COG0540	Belongs to the ATCase OTCase family
FPL04_14715	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FPL04_14720	COG1678	Uncharacterized ACR, COG1678
FPL04_14725	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
FPL04_14730	COG0519	Catalyzes the synthesis of GMP from XMP
FPL04_14750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FPL04_14765	COG4942	peptidase
FPL04_14785	COG0693	protein deglycase activity
FPL04_14795	COG1959	2 iron, 2 sulfur cluster binding
FPL04_14800	COG0719	Fe-S assembly protein
FPL04_14805	COG0396	ATPase activity
FPL04_14810	COG0719	Fe-S assembly protein
FPL04_14815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FPL04_14820	COG0456	acetyltransferase
FPL04_14830	COG4774	siderophore transport
FPL04_14835	COG3128	pkhd-type hydroxylase
FPL04_14860	COG1477	protein flavinylation
FPL04_14880	COG1555	photosystem II stabilization
FPL04_14885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FPL04_14900	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FPL04_14915	COG0628	permease
FPL04_14935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FPL04_14960	COG0271	Belongs to the BolA IbaG family
FPL04_14970	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FPL04_14980	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FPL04_14985	COG1137	ATPase activity
FPL04_15000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FPL04_15020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FPL04_15025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FPL04_15030	COG2239	Acts as a magnesium transporter
FPL04_15040	COG1294	oxidase, subunit
FPL04_15045	COG1271	oxidase subunit
FPL04_15060	COG1113	amino acid transport
FPL04_15075	COG2197	response regulator
FPL04_15080	COG0531	amino acid
FPL04_15135	COG2814	Major facilitator Superfamily
FPL04_15140	COG0754	glutathionylspermidine amidase activity
FPL04_15165	COG1842	Phage shock protein A
FPL04_15185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FPL04_15190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FPL04_15200	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FPL04_15275	COG0477	Major facilitator Superfamily
FPL04_15290	COG2353	YceI-like domain
FPL04_15295	COG3038	cytochrome b561
FPL04_15305	COG1278	Cold shock
FPL04_15320	COG1760	l-serine dehydratase
FPL04_15330	COG0527	aspartate kinase activity
FPL04_15330	COG0460	homoserine dehydrogenase
FPL04_15335	COG0626	cystathionine gamma-synthase activity
FPL04_15340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL04_15345	COG0739	heme binding
FPL04_15350	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FPL04_15355	COG1272	protein, Hemolysin III
FPL04_15360	COG2982	Protein involved in outer membrane biogenesis
FPL04_15375	COG0463	Glycosyl transferase, family 2
FPL04_15380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FPL04_15385	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FPL04_15400	COG1309	transcriptional regulator
FPL04_15410	COG1960	acyl-CoA dehydrogenase activity
FPL04_15445	COG0509	glycine decarboxylation via glycine cleavage system
FPL04_15450	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FPL04_15460	COG0330	HflC and HflK could
FPL04_15465	COG1742	UPF0060 membrane protein
FPL04_15470	COG3956	TIGRFAM MazG family protein
FPL04_15480	COG0494	nUDIX hydrolase
FPL04_15490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FPL04_15495	COG0837	glucose binding
FPL04_15510	COG3858	chitin binding
FPL04_15510	COG1388	LysM domain
FPL04_15520	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL04_15530	COG3537	Alpha-1,2-mannosidase
FPL04_15570	COG1446	asparaginase
FPL04_15575	COG2304	oxidoreductase activity
FPL04_15580	COG1595	DNA-templated transcription, initiation
FPL04_15610	COG0840	transmembrane signaling receptor activity
FPL04_15615	COG0835	chemotaxis
FPL04_15630	COG0189	ligase activity
FPL04_15640	COG1397	ADP-ribosylglycohydrolase
FPL04_15650	COG1199	ATP-dependent helicase activity
FPL04_15660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FPL04_15665	COG1215	transferase activity, transferring glycosyl groups
FPL04_15680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FPL04_15690	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FPL04_15695	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
FPL04_15705	COG0535	radical SAM domain protein
FPL04_15720	COG0837	glucose binding
FPL04_15730	COG1643	Atp-dependent helicase
FPL04_15735	COG0783	Belongs to the Dps family
FPL04_15745	COG0514	ATP-dependent DNA helicase (RecQ)
FPL04_15765	COG1187	pseudouridine synthase activity
FPL04_15775	COG0840	transmembrane signaling receptor activity
FPL04_15800	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FPL04_15820	COG0667	Aldo Keto reductase
FPL04_15825	COG0602	queuosine metabolic process
FPL04_15835	COG2885	chlorophyll binding
FPL04_15840	COG0823	Involved in the tonB-independent uptake of proteins
FPL04_15850	COG0848	biopolymer transport protein
FPL04_15860	COG0824	Thioesterase
FPL04_15865	COG2255	four-way junction helicase activity
FPL04_15880	COG0632	four-way junction helicase activity
FPL04_15905	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FPL04_15920	COG0477	Major facilitator Superfamily
FPL04_15960	COG0488	(ABC) transporter
FPL04_15985	COG2124	cytochrome p450
FPL04_15995	COG4651	solute:proton antiporter activity
FPL04_15995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FPL04_16005	COG4772	TonB-dependent receptor
FPL04_16015	COG4264	IucA IucC family
FPL04_16020	COG2814	Major facilitator Superfamily
FPL04_16025	COG4264	IucA IucC family
FPL04_16030	COG0019	diaminopimelate decarboxylase activity
FPL04_16055	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FPL04_16065	COG4206	TonB-dependent receptor
FPL04_16085	COG0542	response to heat
FPL04_16090	COG1116	anion transmembrane transporter activity
FPL04_16095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL04_16100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FPL04_16105	COG0667	Aldo Keto reductase
FPL04_16115	COG4771	TonB-dependent receptor
FPL04_16160	COG1877	trehalose-phosphatase activity
FPL04_16165	COG3387	PFAM Glycoside hydrolase 15-related
FPL04_16185	COG0840	transmembrane signaling receptor activity
FPL04_16195	COG3011	Protein conserved in bacteria
FPL04_16210	COG0564	pseudouridine synthase activity
FPL04_16215	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL04_16225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FPL04_16225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FPL04_16250	COG0045	succinate-CoA ligase (ADP-forming) activity
FPL04_16285	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FPL04_16305	COG0745	RESPONSE REGULATOR receiver
FPL04_16315	COG0189	ligase activity
FPL04_16370	COG4974	Belongs to the 'phage' integrase family
FPL04_16395	COG0583	DNA-binding transcription factor activity
FPL04_16425	COG2003	Belongs to the UPF0758 family
FPL04_16495	COG3209	COG3209 Rhs family protein
FPL04_16550	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FPL04_16555	COG0471	metal ion transport
FPL04_16555	COG3273	potassium ion transport
FPL04_16575	COG1970	mechanosensitive ion channel activity
FPL04_16585	COG1609	Transcriptional regulator
FPL04_16595	COG3250	beta-galactosidase activity
FPL04_16600	COG4948	Mandelate Racemase Muconate Lactonizing
FPL04_16605	COG2272	Belongs to the type-B carboxylesterase lipase family
FPL04_16610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FPL04_16625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL04_16630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL04_16635	COG2895	sulfate adenylyltransferase (ATP) activity
FPL04_16635	COG0529	Catalyzes the synthesis of activated sulfate
FPL04_16645	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FPL04_16650	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FPL04_16675	COG2198	Histidine kinase
FPL04_16675	COG2205	protein histidine kinase activity
FPL04_16675	COG0784	Response regulator, receiver
FPL04_16690	COG1648	precorrin-2 dehydrogenase activity
FPL04_16690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FPL04_16705	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FPL04_16710	COG3588	fructose-bisphosphate aldolase
FPL04_16715	COG0469	pyruvate kinase activity
FPL04_16755	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FPL04_16770	COG3047	cAMP biosynthetic process
FPL04_16780	COG3453	Protein conserved in bacteria
FPL04_16780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL04_16785	COG0725	ABC transporter, periplasmic molybdate-binding protein
FPL04_16790	COG4149	molybdate abc transporter
FPL04_16825	COG0642	Histidine kinase
FPL04_16830	COG0745	RESPONSE REGULATOR receiver
FPL04_16840	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_16850	COG1022	Amp-dependent synthetase and ligase
FPL04_16875	COG1376	ErfK ybiS ycfS ynhG family protein
FPL04_16880	COG1196	nuclear chromosome segregation
FPL04_16880	COG0739	heme binding
FPL04_16880	COG0741	lytic transglycosylase activity
FPL04_16885	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_16890	COG0583	DNA-binding transcription factor activity
FPL04_16895	COG4773	Receptor
FPL04_16900	COG0596	Alpha beta hydrolase
FPL04_16905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FPL04_16910	COG1301	dicarboxylic acid transport
FPL04_16945	COG0714	Associated with various cellular activities
FPL04_16975	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FPL04_17000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FPL04_17010	COG2721	sulfolactate sulfo-lyase activity
FPL04_17025	COG2271	Major facilitator Superfamily
FPL04_17040	COG0583	DNA-binding transcription factor activity
FPL04_17050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FPL04_17055	COG1758	RNA polymerase activity
FPL04_17065	COG1561	YicC-like family, N-terminal region
FPL04_17070	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FPL04_17085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FPL04_17100	COG0006	proline dipeptidase activity
FPL04_17110	COG0006	proline dipeptidase activity
FPL04_17135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FPL04_17160	COG2912	Transglutaminase-like superfamily
FPL04_17165	COG1773	rubredoxin
FPL04_17170	COG0352	thiamine-phosphate diphosphorylase activity
FPL04_17190	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FPL04_17205	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
FPL04_17210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FPL04_17240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FPL04_17245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FPL04_17260	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_17270	COG0671	phosphoesterase, PA-phosphatase related
FPL04_17275	COG3781	membrane
FPL04_17285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FPL04_17290	COG0563	adenylate kinase activity
FPL04_17305	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FPL04_17315	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FPL04_17335	COG3710	Transcriptional regulator
FPL04_17355	COG1506	peptidase
FPL04_17355	COG0823	Involved in the tonB-independent uptake of proteins
FPL04_17355	COG4946	Tricorn protease homolog
FPL04_17360	COG0840	transmembrane signaling receptor activity
FPL04_17365	COG0405	Gamma-glutamyltransferase
FPL04_17390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FPL04_17400	COG0473	3-isopropylmalate dehydrogenase activity
FPL04_17405	COG0066	3-isopropylmalate dehydratase activity
FPL04_17410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FPL04_17430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FPL04_17435	COG1538	Outer membrane efflux protein
FPL04_17440	COG1519	Transferase
FPL04_17445	COG1560	Kdo2-lipid A biosynthetic process
FPL04_17470	COG0280	phosphate acetyltransferase
FPL04_17470	COG0281	malic enzyme
FPL04_17475	COG1301	dicarboxylic acid transport
FPL04_17485	COG4191	Histidine kinase
FPL04_17500	COG0583	DNA-binding transcription factor activity
FPL04_17515	COG0667	Aldo Keto reductase
FPL04_17520	COG2197	response regulator
FPL04_17525	COG1840	ABC-type Fe3 transport system, periplasmic component
FPL04_17530	COG0642	Histidine kinase
FPL04_17550	COG2851	Citrate transporter
FPL04_17555	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_17560	COG1609	Transcriptional regulator
FPL04_17565	COG2211	Major facilitator Superfamily
FPL04_17625	COG0436	Aminotransferase
FPL04_17650	COG4773	Receptor
FPL04_17655	COG0726	polysaccharide deacetylase
FPL04_17660	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FPL04_17675	COG3964	amidohydrolase
FPL04_17680	COG1228	amidohydrolase
FPL04_17705	COG1307	EDD domain protein, DegV family
FPL04_17720	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FPL04_17725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FPL04_17750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FPL04_17750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FPL04_17765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FPL04_17775	COG0488	(ABC) transporter
FPL04_17780	COG0242	peptide deformylase activity
FPL04_17800	COG0457	Tetratricopeptide repeat
FPL04_17805	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FPL04_17810	COG1215	transferase activity, transferring glycosyl groups
FPL04_17815	COG1215	transferase activity, transferring glycosyl groups
FPL04_17875	COG2188	Transcriptional regulator
FPL04_17885	COG1450	Type ii and iii secretion system protein
FPL04_17900	COG3166	PFAM Fimbrial assembly family protein
FPL04_17905	COG3156	type II secretion system protein K
FPL04_17910	COG4795	General secretion pathway protein
FPL04_17915	COG2165	general secretion pathway protein
FPL04_17920	COG4970	Tfp pilus assembly protein FimT
FPL04_17925	COG2165	general secretion pathway protein
FPL04_17930	COG1459	type II secretion system
FPL04_17935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FPL04_17940	COG1404	Belongs to the peptidase S8 family
FPL04_17945	COG5295	Hep Hag repeat protein
FPL04_17955	COG1404	Belongs to the peptidase S8 family
FPL04_17965	COG0047	phosphoribosylformylglycinamidine synthase activity
FPL04_17965	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FPL04_17970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FPL04_17975	COG4974	Belongs to the 'phage' integrase family
FPL04_17990	COG0795	lipopolysaccharide-transporting ATPase activity
FPL04_18000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FPL04_18035	COG1183	phosphatidylcholine synthase activity
FPL04_18060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FPL04_18065	COG1127	ABC transporter
FPL04_18070	COG3218	ABC-type transport auxiliary lipoprotein component
FPL04_18070	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FPL04_18100	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FPL04_18105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FPL04_18135	COG2086	electron transfer activity
FPL04_18160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL04_18170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FPL04_18175	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FPL04_18190	COG0438	transferase activity, transferring glycosyl groups
FPL04_18215	COG0626	cystathionine gamma-synthase activity
FPL04_18245	COG0625	glutathione transferase activity
FPL04_18260	COG0513	Belongs to the DEAD box helicase family
FPL04_18270	COG4771	TonB-dependent receptor
FPL04_18275	COG0720	synthase
FPL04_18285	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FPL04_18290	COG1956	GAF domain-containing protein
FPL04_18300	COG2819	hydrolase of the alpha beta superfamily
FPL04_18310	COG0546	phosphoglycolate phosphatase activity
FPL04_18315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FPL04_18320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FPL04_18330	COG0339	signal peptide processing
FPL04_18375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FPL04_18380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL04_18385	COG1136	(ABC) transporter
FPL04_18390	COG0577	efflux transmembrane transporter activity
FPL04_18390	COG1136	(ABC) transporter
FPL04_18405	COG2204	response regulator
FPL04_18410	COG4191	Histidine kinase
FPL04_18420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FPL04_18435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FPL04_18445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FPL04_18455	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FPL04_18460	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FPL04_18470	COG0356	it plays a direct role in the translocation of protons across the membrane
FPL04_18485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FPL04_18495	COG0508	dehydrogenase complex catalyzes the overall conversion of
FPL04_18530	COG2011	ABC-type metal ion transport system permease component
FPL04_18535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FPL04_18540	COG0697	spore germination
FPL04_18545	COG1666	GTP binding
FPL04_18555	COG5002	protein histidine kinase activity
FPL04_18555	COG2198	Histidine kinase
FPL04_18555	COG0784	Response regulator, receiver
FPL04_18575	COG1187	pseudouridine synthase activity
FPL04_18600	COG2205	protein histidine kinase activity
FPL04_18600	COG2202	Pas domain
FPL04_18625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FPL04_18630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL04_18635	COG1522	sequence-specific DNA binding
FPL04_18685	COG0842	Transport permease protein
FPL04_18690	COG1131	(ABC) transporter
FPL04_18695	COG0025	NhaP-type Na H and K H
FPL04_18710	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FPL04_18715	COG1573	uracil-dna glycosylase
FPL04_18725	COG3384	dioxygenase
FPL04_18735	COG0583	DNA-binding transcription factor activity
FPL04_18745	COG0667	Aldo Keto reductase
FPL04_18755	COG3590	peptidase
FPL04_18770	COG0531	amino acid
FPL04_18785	COG2972	Histidine kinase
FPL04_18800	COG3685	Protein conserved in bacteria
FPL04_18805	COG3546	catalase activity
FPL04_18830	COG2204	response regulator
FPL04_18840	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_18855	COG1063	alcohol dehydrogenase
FPL04_18880	COG0583	DNA-binding transcription factor activity
FPL04_18885	COG2814	Major facilitator Superfamily
FPL04_18935	COG0251	oxidation-reduction process
FPL04_18950	COG0840	transmembrane signaling receptor activity
FPL04_18985	COG0659	secondary active sulfate transmembrane transporter activity
FPL04_18990	COG0038	chloride channel
FPL04_18995	COG0024	Methionine aminopeptidase
FPL04_19010	COG1309	transcriptional regulator
FPL04_19025	COG0431	NADPH-dependent FMN reductase
FPL04_19030	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FPL04_19060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FPL04_19065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FPL04_19070	COG0300	oxidoreductase activity
FPL04_19080	COG0583	DNA-binding transcription factor activity
FPL04_19095	COG4695	Portal protein
FPL04_19335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FPL04_19340	COG1490	D-aminoacyl-tRNA deacylase activity
FPL04_19345	COG1560	Kdo2-lipid A biosynthetic process
FPL04_19355	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FPL04_19390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FPL04_19390	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FPL04_19400	COG0242	peptide deformylase activity
FPL04_19405	COG1652	LysM domain
FPL04_19410	COG0758	DNA mediated transformation
FPL04_19430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FPL04_19430	COG1754	DNA topoisomerase type I activity
FPL04_19450	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_19460	COG0616	signal peptide processing
FPL04_19465	COG0534	Mate efflux family protein
FPL04_19480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FPL04_19485	COG0625	glutathione transferase activity
FPL04_19500	COG1252	NADH dehydrogenase
FPL04_19505	COG2860	membrane
FPL04_19510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FPL04_19515	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FPL04_19520	COG3437	response regulator, receiver
FPL04_19525	COG2177	Part of the ABC transporter FtsEX involved in
FPL04_19530	COG2884	Cell division ATP-binding protein ftsE
FPL04_19540	COG3118	belongs to the thioredoxin family
FPL04_19545	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FPL04_19555	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
FPL04_19580	COG1473	amidohydrolase
FPL04_19590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL04_19605	COG5383	Protein conserved in bacteria
FPL04_19645	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FPL04_19665	COG3023	N-Acetylmuramoyl-L-alanine amidase
FPL04_19675	COG4948	Mandelate Racemase Muconate Lactonizing
FPL04_19685	COG0531	amino acid
FPL04_19700	COG4682	membrane
FPL04_19705	COG2133	pyrroloquinoline quinone binding
FPL04_19715	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FPL04_19725	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FPL04_19730	COG1610	YqeY-like protein
FPL04_19735	COG1295	ribonuclease BN
FPL04_19740	COG0358	DNA primase activity
FPL04_19760	COG0109	protoheme IX farnesyltransferase activity
FPL04_19790	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FPL04_19805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FPL04_19850	COG0739	heme binding
FPL04_19865	COG2807	transmembrane transport
FPL04_19870	COG0708	Exodeoxyribonuclease III
FPL04_19885	COG1192	Involved in chromosome partitioning
FPL04_19890	COG1475	DNA binding
FPL04_19910	COG0463	Glycosyl transferase, family 2
FPL04_19935	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FPL04_19945	COG0018	arginyl-trna synthetase
FPL04_19960	COG4221	oxidoreductase activity
FPL04_19965	COG2755	lipolytic protein G-D-S-L family
FPL04_19965	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FPL04_19975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL04_19975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL04_19980	COG1166	arginine decarboxylase activity
FPL04_19985	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FPL04_20020	COG0606	chelatase, subunit chli
FPL04_20035	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FPL04_20085	COG1090	epimerase
FPL04_20090	COG0745	RESPONSE REGULATOR receiver
FPL04_20095	COG0642	Histidine kinase
FPL04_20145	COG1011	Hydrolase
FPL04_20150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FPL04_20180	COG2197	response regulator
FPL04_20185	COG4585	Histidine kinase
FPL04_20190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL04_20195	COG1136	(ABC) transporter
FPL04_20220	COG0697	spore germination
FPL04_20245	COG0180	Tryptophanyl-tRNA synthetase
FPL04_20250	COG3237	CsbD-like
FPL04_20295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FPL04_20310	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FPL04_20315	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FPL04_20315	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FPL04_20340	COG2205	protein histidine kinase activity
FPL04_20345	COG0745	RESPONSE REGULATOR receiver
FPL04_20355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FPL04_20380	COG1199	ATP-dependent helicase activity
FPL04_20445	COG0625	glutathione transferase activity
FPL04_20480	COG4555	ABC transporter
FPL04_20490	COG1476	TRANSCRIPTIONal
FPL04_20525	COG1131	(ABC) transporter
FPL04_20530	COG0842	Transport permease protein
FPL04_20535	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FPL04_20545	COG1607	acyl-coa hydrolase
FPL04_20565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FPL04_20570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FPL04_20580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FPL04_20580	COG1042	CoA-binding domain protein
FPL04_20580	COG0045	succinate-CoA ligase (ADP-forming) activity
FPL04_20585	COG2239	Acts as a magnesium transporter
FPL04_20600	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FPL04_20620	COG3100	YcgL domain-containing protein
FPL04_20625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FPL04_20655	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_20680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FPL04_20695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FPL04_20800	COG0210	DNA helicase
FPL04_20815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL04_20820	COG0583	DNA-binding transcription factor activity
FPL04_20825	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FPL04_20835	COG2159	amidohydrolase
FPL04_20840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FPL04_20845	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FPL04_20855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL04_20880	COG3540	Alkaline phosphatase
FPL04_20890	COG2091	lysine biosynthetic process via aminoadipic acid
FPL04_20910	COG1940	carbohydrate kinase activity
FPL04_20920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FPL04_20935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FPL04_20940	COG3162	membrane
FPL04_20985	COG3507	Belongs to the glycosyl hydrolase 43 family
FPL04_21000	COG1028	Short-chain dehydrogenase reductase Sdr
FPL04_21005	COG0179	Fumarylacetoacetate (FAA) hydrolase
FPL04_21010	COG4948	Mandelate Racemase Muconate Lactonizing
FPL04_21015	COG3254	rhamnose metabolic process
FPL04_21020	COG0738	Major facilitator superfamily
FPL04_21025	COG1414	Transcriptional regulator
FPL04_21035	COG1971	Probably functions as a manganese efflux pump
FPL04_21040	COG0784	Response regulator, receiver
FPL04_21040	COG2205	protein histidine kinase activity
FPL04_21045	COG3459	Glycosyltransferase 36 associated
FPL04_21050	COG2211	Major facilitator Superfamily
FPL04_21055	COG3265	gluconokinase activity
FPL04_21060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL04_21090	COG2911	Protein conserved in bacteria
FPL04_21095	COG0729	surface antigen
FPL04_21100	COG4771	TonB-dependent receptor
FPL04_21105	COG0457	Tetratricopeptide repeat
FPL04_21130	COG0519	Catalyzes the synthesis of GMP from XMP
FPL04_21130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FPL04_21140	COG0805	protein transport
FPL04_21145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FPL04_21150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FPL04_21160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FPL04_21175	COG2974	May be involved in recombination
FPL04_21180	COG0037	tRNA processing
FPL04_21190	COG2115	Belongs to the xylose isomerase family
FPL04_21200	COG3661	Belongs to the glycosyl hydrolase 67 family
FPL04_21210	COG4948	Mandelate Racemase Muconate Lactonizing
FPL04_21220	COG1472	Belongs to the glycosyl hydrolase 3 family
FPL04_21225	COG0246	Mannitol dehydrogenase
FPL04_21245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FPL04_21280	COG3386	PFAM SMP-30 Gluconolaconase
FPL04_21290	COG3250	beta-galactosidase activity
FPL04_21295	COG1904	glucuronate isomerase
FPL04_21300	COG3693	PFAM glycoside hydrolase, family 10
FPL04_21315	COG2211	Major facilitator Superfamily
FPL04_21350	COG2937	Belongs to the GPAT DAPAT family
FPL04_21380	COG0284	orotidine-5'-phosphate decarboxylase activity
FPL04_21385	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
FPL04_21395	COG3132	Protein of unknown function, DUF480
FPL04_21405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FPL04_21455	COG0210	DNA helicase
FPL04_21460	COG1435	thymidine kinase activity
FPL04_21470	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
FPL04_21480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FPL04_21510	COG3135	benzoate transporter
FPL04_21535	COG0676	glucose-6-phosphate 1-epimerase activity
FPL04_21545	COG3012	SEC-C Motif Domain Protein
FPL04_21550	COG0730	response to heat
FPL04_21570	COG0302	gtp cyclohydrolase
FPL04_21585	COG1566	PFAM secretion protein HlyD family protein
FPL04_21595	COG1289	transmembrane transporter activity
FPL04_21600	COG0477	Major facilitator Superfamily
FPL04_21605	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
FPL04_21610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL04_21665	COG0564	pseudouridine synthase activity
FPL04_21735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FPL04_21740	COG1074	ATP-dependent DNA helicase activity
FPL04_21740	COG1074	ATP-dependent DNA helicase activity
FPL04_21745	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FPL04_21780	COG1127	ABC transporter
FPL04_21785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FPL04_21790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FPL04_21805	COG2853	Lipoprotein
FPL04_21810	COG0386	Belongs to the glutathione peroxidase family
FPL04_21820	COG1322	Protein conserved in bacteria
FPL04_21830	COG0531	amino acid
FPL04_21835	COG3537	Alpha-1,2-mannosidase
FPL04_21850	COG3706	GGDEF domain
FPL04_21855	COG3835	regulator
FPL04_21860	COG1929	Belongs to the glycerate kinase type-1 family
FPL04_21865	COG2271	Major facilitator Superfamily
FPL04_21880	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FPL04_21890	COG0861	Integral membrane protein TerC family
FPL04_21900	COG0584	glycerophosphoryl diester phosphodiesterase
FPL04_21910	COG0671	phosphoesterase, PA-phosphatase related
FPL04_21920	COG0726	polysaccharide deacetylase
FPL04_21925	COG0706	membrane insertase activity
FPL04_21935	COG0230	Belongs to the bacterial ribosomal protein bL34 family