locus-tag	class	description
C2859_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2859_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2859_00025	COG0187	DNA topoisomerase II activity
C2859_00035	COG0501	Belongs to the peptidase M48B family
C2859_00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2859_00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2859_00120	COG0793	Belongs to the peptidase S41A family
C2859_00125	COG4942	peptidase
C2859_00135	COG2234	aminopeptidase activity
C2859_00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C2859_00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C2859_00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C2859_00170	COG1064	alcohol dehydrogenase
C2859_00175	COG0493	'glutamate synthase
C2859_00180	COG0067	glutamate synthase
C2859_00180	COG0070	glutamate synthase
C2859_00180	COG0069	glutamate synthase activity
C2859_00230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2859_00245	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C2859_00250	COG0438	transferase activity, transferring glycosyl groups
C2859_00250	COG0297	glycogen (starch) synthase activity
C2859_00270	COG0367	asparagine synthase
C2859_00300	COG1132	(ABC) transporter
C2859_00425	COG1205	dead DEAH box helicase
C2859_00425	COG1111	helicase
C2859_00430	COG1272	protein, Hemolysin III
C2859_00455	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_00480	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2859_00490	COG3237	CsbD-like
C2859_00535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2859_00545	COG0477	Major facilitator Superfamily
C2859_00585	COG0714	Associated with various cellular activities
C2859_00615	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C2859_00625	COG4772	TonB-dependent receptor
C2859_00635	COG0662	Cupin 2, conserved barrel domain protein
C2859_00640	COG1012	belongs to the aldehyde dehydrogenase family
C2859_00665	COG1304	FMN binding
C2859_00680	COG4585	Histidine kinase
C2859_00685	COG2197	response regulator
C2859_00705	COG3710	Transcriptional regulator
C2859_00710	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2859_00750	COG2131	deaminase
C2859_00785	COG0366	Alpha amylase catalytic
C2859_00790	COG0366	Alpha amylase catalytic
C2859_00795	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C2859_00815	COG0657	acetylesterase activity
C2859_00815	COG2755	lipolytic protein G-D-S-L family
C2859_00825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C2859_00840	COG3507	Belongs to the glycosyl hydrolase 43 family
C2859_00845	COG1609	Transcriptional regulator
C2859_00865	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C2859_00870	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_00880	COG2755	lipolytic protein G-D-S-L family
C2859_00895	COG3186	Phenylalanine-4-hydroxylase
C2859_00900	COG1522	sequence-specific DNA binding
C2859_00910	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2859_00920	COG1119	ATPase activity
C2859_00935	COG1125	glycine betaine transport
C2859_00950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2859_00970	COG3550	peptidyl-serine autophosphorylation
C2859_00975	COG1396	sequence-specific DNA binding
C2859_01000	COG0489	protein tyrosine kinase activity
C2859_01005	COG2062	phosphohistidine phosphatase, SixA
C2859_01015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2859_01065	COG1968	undecaprenyl-diphosphatase activity
C2859_01075	COG0174	glutamine synthetase
C2859_01080	COG0347	Belongs to the P(II) protein family
C2859_01085	COG0004	ammonium transporteR
C2859_01090	COG3852	Histidine kinase
C2859_01095	COG2204	response regulator
C2859_01100	COG2032	superoxide dismutase activity
C2859_01105	COG2032	superoxide dismutase activity
C2859_01115	COG0346	lactoylglutathione lyase activity
C2859_01125	COG0183	Belongs to the thiolase family
C2859_01160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2859_01165	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C2859_01170	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2859_01225	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2859_01230	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2859_01235	COG4786	Flagellar basal body rod
C2859_01240	COG4786	Flagellar basal body rod
C2859_01255	COG1706	bacterial-type flagellum-dependent cell motility
C2859_01270	COG1677	Flagellar hook-basal body complex protein FliE
C2859_01275	COG1766	The M ring may be actively involved in energy transduction
C2859_01290	COG1157	protein secretion by the type III secretion system
C2859_01305	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C2859_01340	COG0028	Belongs to the TPP enzyme family
C2859_01345	COG2205	protein histidine kinase activity
C2859_01370	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2859_01385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2859_01395	COG0596	Alpha beta hydrolase
C2859_01405	COG0318	PFAM AMP-dependent synthetase and ligase
C2859_01410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2859_01430	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2859_01440	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2859_01450	COG0564	pseudouridine synthase activity
C2859_01470	COG1446	asparaginase
C2859_01475	COG0339	signal peptide processing
C2859_01510	COG0475	glutathione-regulated potassium exporter activity
C2859_01515	COG0583	DNA-binding transcription factor activity
C2859_01520	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2859_01525	COG2224	Isocitrate lyase
C2859_01530	COG3706	GGDEF domain
C2859_01560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2859_01565	COG1960	acyl-CoA dehydrogenase activity
C2859_01620	COG0523	cobalamin synthesis protein
C2859_01635	COG0697	spore germination
C2859_01645	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2859_01650	COG1846	Transcriptional regulator
C2859_01655	COG1764	response to oxidative stress
C2859_01685	COG2130	NADP-dependent
C2859_01700	COG1187	pseudouridine synthase activity
C2859_01715	COG1643	Atp-dependent helicase
C2859_01725	COG4807	Protein conserved in bacteria
C2859_01730	COG2351	hydroxyisourate hydrolase activity
C2859_01735	COG2072	flavoprotein involved in K transport
C2859_01755	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2859_01790	COG1957	nucleoside hydrolase
C2859_01800	COG2252	PERMEase
C2859_01825	COG0084	hydrolase, TatD family'
C2859_01840	COG0583	DNA-binding transcription factor activity
C2859_01845	COG2814	Major facilitator Superfamily
C2859_01860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2859_01865	COG1902	pentaerythritol trinitrate reductase activity
C2859_01885	COG0745	RESPONSE REGULATOR receiver
C2859_01890	COG2205	protein histidine kinase activity
C2859_01895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2859_01905	COG1538	Outer membrane efflux protein
C2859_01920	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2859_01925	COG0583	DNA-binding transcription factor activity
C2859_01960	COG0702	epimerase
C2859_01965	COG1733	regulation of RNA biosynthetic process
C2859_02045	COG0129	dihydroxy-acid dehydratase activity
C2859_02060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2859_02120	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2859_02125	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2859_02150	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2859_02155	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2859_02165	COG3485	protocatechuate 3,4-dioxygenase
C2859_02170	COG3485	protocatechuate 3,4-dioxygenase
C2859_02180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2859_02185	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2859_02200	COG1414	Transcriptional regulator
C2859_02220	COG0445	tRNA wobble uridine modification
C2859_02260	COG2267	carboxylic ester hydrolase activity
C2859_02270	COG0156	8-amino-7-oxononanoate synthase activity
C2859_02275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2859_02280	COG1040	competence protein
C2859_02285	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C2859_02375	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2859_02460	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2859_02470	COG2354	Protein conserved in bacteria
C2859_02475	COG3706	GGDEF domain
C2859_02475	COG0745	RESPONSE REGULATOR receiver
C2859_02480	COG0297	glycogen (starch) synthase activity
C2859_02485	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C2859_02490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C2859_02515	COG0702	epimerase
C2859_02520	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_02545	COG0513	Belongs to the DEAD box helicase family
C2859_02550	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2859_02565	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2859_02575	COG3483	tryptophan 2,3-dioxygenase activity
C2859_02580	COG3104	oligopeptide transport
C2859_02600	COG2852	Protein conserved in bacteria
C2859_02605	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C2859_02625	COG1320	monovalent cation:proton antiporter activity
C2859_02630	COG2212	antiporter activity
C2859_02640	COG0651	ATP synthesis coupled electron transport
C2859_02645	COG1006	Multisubunit Na H antiporter MnhC subunit
C2859_02650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2859_02650	COG2111	Na H antiporter
C2859_02675	COG3179	chitinase
C2859_02700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2859_02705	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2859_02720	COG0456	acetyltransferase
C2859_02725	COG1597	lipid kinase activity
C2859_02755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2859_02760	COG0134	indole-3-glycerol-phosphate synthase activity
C2859_02770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2859_02775	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C2859_02785	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C2859_02790	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2859_02795	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2859_02810	COG1051	belongs to the nudix hydrolase family
C2859_02850	COG0316	Belongs to the HesB IscA family
C2859_02870	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C2859_02885	COG2814	Major facilitator Superfamily
C2859_02895	COG2814	Major facilitator Superfamily
C2859_02900	COG1289	transmembrane transporter activity
C2859_02910	COG0151	Belongs to the GarS family
C2859_02920	COG0138	bifunctional purine biosynthesis protein purh
C2859_02925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2859_02930	COG2267	carboxylic ester hydrolase activity
C2859_02935	COG2453	phosphatase
C2859_02935	COG0671	phosphoesterase, PA-phosphatase related
C2859_02960	COG4589	Belongs to the CDS family
C2859_02965	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C2859_02990	COG2264	protein methyltransferase activity
C2859_03015	COG0439	Biotin carboxylase
C2859_03025	COG0511	ligase activity, forming carbon-carbon bonds
C2859_03030	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2859_03040	COG1324	tolerance protein
C2859_03070	COG0300	oxidoreductase activity
C2859_03075	COG2356	endonuclease I
C2859_03085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2859_03090	COG0459	protein refolding
C2859_03105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2859_03120	COG3386	PFAM SMP-30 Gluconolaconase
C2859_03130	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C2859_03135	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2859_03155	COG0778	Nitroreductase
C2859_03160	COG2353	YceI-like domain
C2859_03190	COG3052	prosthetic group binding
C2859_03210	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C2859_03225	COG1802	Transcriptional regulator
C2859_03355	COG4221	oxidoreductase activity
C2859_03370	COG4221	oxidoreductase activity
C2859_03380	COG0435	Glutathione S-transferase
C2859_03400	COG2409	Drug exporters of the RND superfamily
C2859_03410	COG0823	Involved in the tonB-independent uptake of proteins
C2859_03410	COG1506	peptidase
C2859_03430	COG3706	GGDEF domain
C2859_03455	COG0697	spore germination
C2859_03470	COG1113	amino acid transport
C2859_03480	COG0598	Magnesium transport protein CorA
C2859_03490	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C2859_03535	COG5001	Diguanylate cyclase
C2859_03540	COG0840	transmembrane signaling receptor activity
C2859_03545	COG5297	Belongs to the glycosyl hydrolase family 6
C2859_03545	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C2859_03550	COG0659	secondary active sulfate transmembrane transporter activity
C2859_03560	COG3706	GGDEF domain
C2859_03580	COG2943	transferase activity, transferring hexosyl groups
C2859_03590	COG3275	phosphorelay sensor kinase activity
C2859_03600	COG0181	hydroxymethylbilane synthase activity
C2859_03630	COG1505	serine-type exopeptidase activity
C2859_03650	COG2832	Protein of unknown function (DUF454)
C2859_03660	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2859_03670	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2859_03675	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2859_03680	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2859_03705	COG2226	methyltransferase
C2859_03710	COG5001	Diguanylate cyclase
C2859_03710	COG3300	MHYT domain
C2859_03715	COG0308	aminopeptidase N
C2859_03765	COG3284	Transcriptional regulator
C2859_03775	COG1077	Cell shape determining protein MreB Mrl
C2859_03780	COG1792	Involved in formation and maintenance of cell shape
C2859_03795	COG0772	Belongs to the SEDS family
C2859_03805	COG2951	lytic endotransglycosylase activity
C2859_03810	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2859_03820	COG1686	Belongs to the peptidase S11 family
C2859_03830	COG2921	Belongs to the UPF0250 family
C2859_03835	COG0321	lipoyl(octanoyl) transferase activity
C2859_03840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2859_03855	COG0583	DNA-binding transcription factor activity
C2859_03865	COG1056	cytidyltransferase-related domain
C2859_03865	COG1051	belongs to the nudix hydrolase family
C2859_03900	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C2859_03905	COG0673	inositol 2-dehydrogenase activity
C2859_03910	COG2823	Periplasmic or secreted lipoprotein
C2859_03915	COG4251	negative regulation of phosphorylation
C2859_03920	COG0784	Response regulator, receiver
C2859_03925	COG4191	Histidine kinase
C2859_03930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2859_03935	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_03990	COG1459	type II secretion system
C2859_04010	COG4795	General secretion pathway protein
C2859_04040	COG3250	beta-galactosidase activity
C2859_04065	COG1609	Transcriptional regulator
C2859_04070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2859_04075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2859_04085	COG0617	tRNA 3'-terminal CCA addition
C2859_04090	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C2859_04095	COG1012	belongs to the aldehyde dehydrogenase family
C2859_04100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2859_04115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2859_04130	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2859_04135	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C2859_04155	COG2205	protein histidine kinase activity
C2859_04160	COG0745	RESPONSE REGULATOR receiver
C2859_04185	COG3791	Glutathione-dependent formaldehyde-activating
C2859_04200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2859_04220	COG0488	(ABC) transporter
C2859_04230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2859_04235	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2859_04245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2859_04245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2859_04265	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2859_04270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2859_04275	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2859_04300	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C2859_04305	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C2859_04310	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C2859_04315	COG2205	protein histidine kinase activity
C2859_04320	COG0745	RESPONSE REGULATOR receiver
C2859_04335	COG0277	FAD linked oxidase domain protein
C2859_04340	COG1988	membrane-bound metal-dependent
C2859_04345	COG0792	nuclease activity
C2859_04380	COG2001	Belongs to the MraZ family
C2859_04385	COG0275	rRNA processing
C2859_04390	COG3116	cell division
C2859_04400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2859_04405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2859_04410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2859_04420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2859_04425	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2859_04430	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2859_04435	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2859_04450	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C2859_04460	COG0739	heme binding
C2859_04465	COG0653	protein targeting
C2859_04470	COG0494	nUDIX hydrolase
C2859_04480	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2859_04495	COG0604	alcohol dehydrogenase
C2859_04495	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_04495	COG3321	synthase
C2859_04525	COG0366	Alpha amylase catalytic
C2859_04555	COG2226	methyltransferase
C2859_04560	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C2859_04570	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C2859_04615	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C2859_04625	COG4106	trans-aconitate 2-methyltransferase activity
C2859_04630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2859_04640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2859_04645	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2859_04655	COG0667	Aldo Keto reductase
C2859_04665	COG4771	TonB-dependent receptor
C2859_04685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2859_04690	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2859_04700	COG2175	clavaminate synthase activity
C2859_04710	COG4181	ATPase activity
C2859_04725	COG0642	Histidine kinase
C2859_04740	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2859_04760	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C2859_04765	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C2859_04780	COG3829	transcription factor binding
C2859_04790	COG1116	anion transmembrane transporter activity
C2859_04795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2859_04805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2859_04810	COG0431	NADPH-dependent FMN reductase
C2859_04840	COG0747	negative chemotaxis
C2859_04860	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2859_04865	COG2967	ApaG domain
C2859_04870	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2859_04875	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2859_04880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2859_04885	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2859_04890	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2859_04895	COG2096	Adenosyltransferase
C2859_04910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2859_04915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2859_04945	COG3384	dioxygenase
C2859_04950	COG0583	DNA-binding transcription factor activity
C2859_04965	COG1024	Enoyl-CoA hydratase
C2859_04985	COG3386	PFAM SMP-30 Gluconolaconase
C2859_05000	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C2859_05020	COG0697	spore germination
C2859_05030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2859_05045	COG0745	RESPONSE REGULATOR receiver
C2859_05045	COG3706	GGDEF domain
C2859_05055	COG2197	response regulator
C2859_05065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2859_05075	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2859_05080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2859_05090	COG0583	DNA-binding transcription factor activity
C2859_05095	COG3634	alkyl hydroperoxide reductase activity
C2859_05105	COG2890	protein-(glutamine-N5) methyltransferase activity
C2859_05125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2859_05125	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2859_05155	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2859_05175	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2859_05180	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C2859_05195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2859_05200	COG1404	Belongs to the peptidase S8 family
C2859_05205	COG1404	Belongs to the peptidase S8 family
C2859_05210	COG1404	Belongs to the peptidase S8 family
C2859_05215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2859_05240	COG1295	ribonuclease BN
C2859_05245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2859_05250	COG1254	Belongs to the acylphosphatase family
C2859_05265	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2859_05275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2859_05280	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2859_05290	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C2859_05295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2859_05305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2859_05310	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2859_05315	COG0193	aminoacyl-tRNA hydrolase activity
C2859_05320	COG0012	GTP binding
C2859_05340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2859_05350	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2859_05355	COG0250	Participates in transcription elongation, termination and antitermination
C2859_05360	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C2859_05365	COG0081	regulation of translation
C2859_05370	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2859_05375	COG0222	ribosome binding
C2859_05380	COG0085	RNA polymerase activity
C2859_05385	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2859_05390	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2859_05395	COG0049	tRNA binding
C2859_05400	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2859_05405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2859_05410	COG0051	transcription antitermination factor activity, RNA binding
C2859_05415	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2859_05420	COG0088	Forms part of the polypeptide exit tunnel
C2859_05425	COG0089	rRNA binding
C2859_05430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2859_05435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2859_05440	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C2859_05445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C2859_05450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2859_05455	COG0255	Belongs to the universal ribosomal protein uL29 family
C2859_05460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2859_05465	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2859_05470	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C2859_05475	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2859_05480	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2859_05485	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C2859_05490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2859_05495	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2859_05500	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2859_05505	COG1841	ribosomal large subunit assembly
C2859_05510	COG0200	Binds to the 23S rRNA
C2859_05515	COG0201	protein transport
C2859_05520	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2859_05525	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2859_05530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2859_05535	COG0202	RNA polymerase activity
C2859_05540	COG0203	ribosomal protein L17
C2859_05545	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2859_05565	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C2859_05575	COG0154	amidase activity
C2859_05590	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2859_05595	COG0039	L-malate dehydrogenase activity
C2859_05600	COG0625	glutathione transferase activity
C2859_05620	COG1902	pentaerythritol trinitrate reductase activity
C2859_05620	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2859_05625	COG0604	alcohol dehydrogenase
C2859_05655	COG0156	8-amino-7-oxononanoate synthase activity
C2859_05660	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2859_05665	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2859_05670	COG4208	sulfate ABC transporter
C2859_05675	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2859_05685	COG1063	alcohol dehydrogenase
C2859_05710	COG0406	alpha-ribazole phosphatase activity
C2859_05715	COG0285	dihydrofolate synthase activity
C2859_05735	COG2833	Protein of unknown function (DUF455)
C2859_05755	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2859_05760	COG0671	phosphoesterase, PA-phosphatase related
C2859_05765	COG0438	transferase activity, transferring glycosyl groups
C2859_05775	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C2859_05790	COG4783	chaperone-mediated protein folding
C2859_05805	COG0473	3-isopropylmalate dehydrogenase activity
C2859_06060	COG4695	Portal protein
C2859_06120	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2859_06125	COG0740	serine-type endopeptidase activity
C2859_06130	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2859_06160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2859_06170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2859_06180	COG0328	RNA-DNA hybrid ribonuclease activity
C2859_06185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2859_06190	COG0631	protein serine/threonine phosphatase activity
C2859_06205	COG0859	PFAM glycosyl transferase family 9
C2859_06210	COG3642	lipopolysaccharide core region biosynthetic process
C2859_06215	COG1234	tRNA 3'-trailer cleavage
C2859_06220	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2859_06235	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2859_06240	COG0314	molybdopterin synthase activity
C2859_06260	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2859_06265	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2859_06270	COG0537	adenosine 5'-monophosphoramidase activity
C2859_06290	COG0714	Associated with various cellular activities
C2859_06310	COG0424	maF-like protein
C2859_06315	COG1399	metal-binding, possibly nucleic acid-binding protein
C2859_06320	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C2859_06325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2859_06340	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_06345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2859_06355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2859_06360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2859_06405	COG3829	transcription factor binding
C2859_06425	COG3609	addiction module antidote protein, CC2985 family
C2859_06460	COG2373	Large extracellular alpha-helical protein
C2859_06480	COG4953	penicillin-binding protein 1C
C2859_06490	COG0678	peroxiredoxin activity
C2859_06510	COG0330	HflC and HflK could
C2859_06515	COG0330	HflC and HflK could
C2859_06525	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C2859_06530	COG0308	aminopeptidase N
C2859_06535	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_06540	COG1309	transcriptional regulator
C2859_06570	COG0732	type I restriction modification DNA specificity domain
C2859_06600	COG0406	alpha-ribazole phosphatase activity
C2859_06600	COG0328	RNA-DNA hybrid ribonuclease activity
C2859_06605	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2859_06615	COG3387	PFAM Glycoside hydrolase 15-related
C2859_06620	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_06625	COG3537	Alpha-1,2-mannosidase
C2859_06630	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_06645	COG0492	ferredoxin-NADP+ reductase activity
C2859_06670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2859_06675	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2859_06680	COG2080	2 iron, 2 sulfur cluster binding
C2859_06715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2859_06730	COG0587	DNA-directed DNA polymerase activity
C2859_06750	COG1297	OPT oligopeptide transporter protein
C2859_06765	COG1506	peptidase
C2859_06765	COG0823	Involved in the tonB-independent uptake of proteins
C2859_06785	COG1917	Cupin 2, conserved barrel domain protein
C2859_06785	COG2207	Transcriptional regulator
C2859_06805	COG0753	catalase activity
C2859_06810	COG0656	L-ascorbic acid biosynthetic process
C2859_06820	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2859_06820	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2859_06825	COG2814	Major facilitator Superfamily
C2859_06840	COG2194	sulfuric ester hydrolase activity
C2859_06855	COG0745	RESPONSE REGULATOR receiver
C2859_06860	COG0642	Histidine kinase
C2859_06870	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C2859_06875	COG2894	cell division
C2859_06880	COG0850	regulation of cytokinetic process
C2859_06895	COG4585	Histidine kinase
C2859_06900	COG2197	response regulator
C2859_06915	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2859_06950	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C2859_06960	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C2859_06980	COG1946	Acyl-CoA thioesterase
C2859_06995	COG0824	Thioesterase
C2859_07000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2859_07005	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2859_07010	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2859_07015	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2859_07020	COG0268	Binds directly to 16S ribosomal RNA
C2859_07030	COG0196	riboflavin kinase activity
C2859_07035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2859_07040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2859_07045	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2859_07060	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2859_07065	COG1845	cytochrome c oxidase, subunit III
C2859_07070	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2859_07090	COG3152	Membrane
C2859_07100	COG2207	Transcriptional regulator
C2859_07105	COG0326	Molecular chaperone. Has ATPase activity
C2859_07120	COG1366	Belongs to the anti-sigma-factor antagonist family
C2859_07125	COG1366	Belongs to the anti-sigma-factor antagonist family
C2859_07130	COG2172	sigma factor antagonist activity
C2859_07155	COG4771	TonB-dependent receptor
C2859_07165	COG5507	3-demethylubiquinone-9 3-methyltransferase
C2859_07170	COG2205	protein histidine kinase activity
C2859_07180	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2859_07185	COG2205	protein histidine kinase activity
C2859_07185	COG4999	Histidine kinase
C2859_07185	COG3850	Histidine kinase
C2859_07185	COG3437	response regulator, receiver
C2859_07190	COG4191	Histidine kinase
C2859_07190	COG0784	Response regulator, receiver
C2859_07215	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2859_07220	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2859_07230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2859_07235	COG0228	four-way junction DNA binding
C2859_07240	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2859_07245	COG0336	Belongs to the RNA methyltransferase TrmD family
C2859_07250	COG0335	large ribosomal subunit rRNA binding
C2859_07255	COG0534	Mate efflux family protein
C2859_07275	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C2859_07285	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2859_07330	COG3250	beta-galactosidase activity
C2859_07335	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C2859_07355	COG1960	acyl-CoA dehydrogenase activity
C2859_07360	COG1024	Enoyl-CoA hydratase
C2859_07395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2859_07400	COG0481	GTPase activity
C2859_07415	COG0571	ribonuclease III activity
C2859_07420	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2859_07425	COG1381	Involved in DNA repair and RecF pathway recombination
C2859_07435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2859_07445	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2859_07450	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C2859_07455	COG3046	protein related to deoxyribodipyrimidine photolyase
C2859_07460	COG1472	Belongs to the glycosyl hydrolase 3 family
C2859_07470	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C2859_07475	COG1278	Cold shock
C2859_07495	COG1201	RNA secondary structure unwinding
C2859_07500	COG1793	dna ligase
C2859_07510	COG1793	dna ligase
C2859_07510	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C2859_07525	COG3706	GGDEF domain
C2859_07525	COG0745	RESPONSE REGULATOR receiver
C2859_07540	COG0183	Belongs to the thiolase family
C2859_07565	COG1451	nucleotide metabolic process
C2859_07570	COG5487	UPF0391 membrane protein
C2859_07580	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2859_07595	COG1077	Cell shape determining protein MreB Mrl
C2859_07600	COG1047	Peptidyl-prolyl cis-trans
C2859_07610	COG2824	Alkylphosphonate utilization operon protein PhnA
C2859_07620	COG1902	pentaerythritol trinitrate reductase activity
C2859_07625	COG2814	Major facilitator Superfamily
C2859_07660	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C2859_07660	COG0392	lysyltransferase activity
C2859_07670	COG0251	oxidation-reduction process
C2859_07675	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2859_07690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2859_07715	COG1595	DNA-templated transcription, initiation
C2859_07735	COG2878	Part of a membrane complex involved in electron transport
C2859_07745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2859_07745	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2859_07760	COG1131	(ABC) transporter
C2859_07765	COG0346	lactoylglutathione lyase activity
C2859_07770	COG0833	amino acid
C2859_07775	COG2040	homocysteine
C2859_07785	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2859_07805	COG1695	Transcriptional regulator
C2859_07840	COG0825	malonyl-CoA metabolic process
C2859_07850	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2859_07855	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2859_07860	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2859_07865	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2859_07870	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2859_07885	COG0750	zinc metalloprotease
C2859_07890	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2859_07895	COG0575	Belongs to the CDS family
C2859_07900	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2859_07905	COG0233	cytoplasmic translational termination
C2859_07910	COG0528	UMP kinase activity
C2859_07915	COG3706	GGDEF domain
C2859_07915	COG0745	RESPONSE REGULATOR receiver
C2859_07920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2859_07925	COG0052	Belongs to the universal ribosomal protein uS2 family
C2859_07960	COG0024	Methionine aminopeptidase
C2859_07965	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C2859_07975	COG1393	Belongs to the ArsC family
C2859_07980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2859_07985	COG0367	asparagine synthase
C2859_07995	COG4774	siderophore transport
C2859_08010	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2859_08045	COG1566	PFAM secretion protein HlyD family protein
C2859_08050	COG2814	Major facilitator Superfamily
C2859_08070	COG3104	oligopeptide transport
C2859_08100	COG0339	signal peptide processing
C2859_08110	COG0386	Belongs to the glutathione peroxidase family
C2859_08165	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2859_08170	COG0084	hydrolase, TatD family'
C2859_08185	COG1960	acyl-CoA dehydrogenase activity
C2859_08205	COG0367	asparagine synthase
C2859_08215	COG0305	Participates in initiation and elongation during chromosome replication
C2859_08220	COG0415	Belongs to the DNA photolyase family
C2859_08240	COG0583	DNA-binding transcription factor activity
C2859_08275	COG3706	GGDEF domain
C2859_08285	COG3706	GGDEF domain
C2859_08320	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2859_08335	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2859_08345	COG0497	DNA recombination
C2859_08350	COG1420	regulation of RNA biosynthetic process
C2859_08355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2859_08360	COG0443	Heat shock 70 kDa protein
C2859_08365	COG0484	heat shock protein binding
C2859_08375	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2859_08405	COG0583	DNA-binding transcription factor activity
C2859_08410	COG1132	(ABC) transporter
C2859_08445	COG2850	peptidyl-arginine hydroxylation
C2859_08465	COG1253	flavin adenine dinucleotide binding
C2859_08495	COG1131	(ABC) transporter
C2859_08500	COG1725	Transcriptional regulator
C2859_08510	COG0386	Belongs to the glutathione peroxidase family
C2859_08525	COG2900	Belongs to the SlyX family
C2859_08550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2859_08560	COG0646	methionine synthase
C2859_08560	COG1410	methionine synthase
C2859_08565	COG1410	methionine synthase
C2859_08565	COG0646	methionine synthase
C2859_08575	COG1960	acyl-CoA dehydrogenase activity
C2859_08580	COG1960	acyl-CoA dehydrogenase activity
C2859_08585	COG1960	acyl-CoA dehydrogenase activity
C2859_08590	COG1960	acyl-CoA dehydrogenase activity
C2859_08595	COG1960	acyl-CoA dehydrogenase activity
C2859_08615	COG0557	exoribonuclease II activity
C2859_08625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2859_08630	COG3706	GGDEF domain
C2859_08635	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2859_08645	COG0704	Plays a role in the regulation of phosphate uptake
C2859_08650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2859_08655	COG0581	inorganic phosphate transmembrane transporter activity
C2859_08660	COG0573	inorganic phosphate transmembrane transporter activity
C2859_08665	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2859_08690	COG0659	secondary active sulfate transmembrane transporter activity
C2859_08695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2859_08705	COG1024	Enoyl-CoA hydratase
C2859_08715	COG0494	nUDIX hydrolase
C2859_08760	COG0116	Belongs to the methyltransferase superfamily
C2859_08760	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2859_08765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2859_08790	COG2925	Exonuclease
C2859_08800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2859_08805	COG3844	kynureninase activity
C2859_08815	COG0662	Cupin 2, conserved barrel domain protein
C2859_08820	COG0288	reversible hydration of carbon dioxide
C2859_08885	COG2808	Putative FMN-binding domain
C2859_08905	COG0017	Asparaginyl-tRNA synthetase
C2859_08915	COG0316	Belongs to the HesB IscA family
C2859_08920	COG0360	Binds together with S18 to 16S ribosomal RNA
C2859_08925	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2859_08930	COG0359	binds to the 23S rRNA
C2859_08940	COG3115	cell septum assembly
C2859_08950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2859_08955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2859_08960	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C2859_08975	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C2859_08985	COG4993	Dehydrogenase
C2859_09000	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C2859_09010	COG2986	histidine ammonia-lyase
C2859_09015	COG1228	amidohydrolase
C2859_09060	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C2859_09065	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2859_09070	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2859_09075	COG0077	Prephenate dehydratase
C2859_09075	COG1605	Chorismate mutase
C2859_09080	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2859_09095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2859_09100	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2859_09105	COG0583	DNA-binding transcription factor activity
C2859_09120	COG0840	transmembrane signaling receptor activity
C2859_09145	COG2205	protein histidine kinase activity
C2859_09145	COG5002	protein histidine kinase activity
C2859_09145	COG0784	Response regulator, receiver
C2859_09155	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C2859_09160	COG0784	Response regulator, receiver
C2859_09160	COG4191	Histidine kinase
C2859_09175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2859_09185	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C2859_09195	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2859_09210	COG1595	DNA-templated transcription, initiation
C2859_09265	COG2244	polysaccharide biosynthetic process
C2859_09295	COG2264	protein methyltransferase activity
C2859_09320	COG1136	(ABC) transporter
C2859_09330	COG0477	Major facilitator Superfamily
C2859_09335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2859_09350	COG1253	flavin adenine dinucleotide binding
C2859_09365	COG0306	phosphate transporter
C2859_09390	COG0504	CTP synthase activity
C2859_09395	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C2859_09405	COG0148	phosphopyruvate hydratase activity
C2859_09410	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2859_09415	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2859_09420	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C2859_09425	COG0585	pseudouridine synthase activity
C2859_09430	COG2840	Smr protein MutS2
C2859_09435	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C2859_09440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2859_09445	COG1238	metal cluster binding
C2859_09465	COG1534	Rna-binding protein
C2859_09470	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C2859_09475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2859_09480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2859_09485	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2859_09490	COG1923	regulation of RNA biosynthetic process
C2859_09495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2859_09500	COG1546	Belongs to the CinA family
C2859_09510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2859_09515	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2859_09525	COG2137	regulation of response to DNA damage stimulus
C2859_09530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2859_09535	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2859_09695	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C2859_09750	COG3179	chitinase
C2859_09830	COG1196	nuclear chromosome segregation
C2859_09895	COG0582	viral genome integration into host DNA
C2859_09910	COG1741	Belongs to the pirin family
C2859_09915	COG0583	DNA-binding transcription factor activity
C2859_09940	COG0351	phosphomethylpyrimidine kinase
C2859_09955	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2859_09960	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2859_09975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2859_09985	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C2859_09990	COG3734	2-keto-3-deoxy-galactonokinase
C2859_10000	COG4948	Mandelate Racemase Muconate Lactonizing
C2859_10005	COG0800	Aldolase
C2859_10045	COG1501	Belongs to the glycosyl hydrolase 31 family
C2859_10055	COG1070	Carbohydrate kinase
C2859_10060	COG2115	Belongs to the xylose isomerase family
C2859_10065	COG0477	Major facilitator Superfamily
C2859_10085	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2859_10090	COG1469	GTP cyclohydrolase I activity
C2859_10110	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2859_10115	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2859_10120	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C2859_10125	COG0166	Belongs to the GPI family
C2859_10150	COG1472	Belongs to the glycosyl hydrolase 3 family
C2859_10165	COG2203	Gaf domain
C2859_10165	COG3706	GGDEF domain
C2859_10165	COG4251	negative regulation of phosphorylation
C2859_10165	COG5001	Diguanylate cyclase
C2859_10175	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C2859_10180	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C2859_10190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C2859_10195	COG0671	phosphoesterase, PA-phosphatase related
C2859_10210	COG1794	racemase activity, acting on amino acids and derivatives
C2859_10220	COG0697	spore germination
C2859_10225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2859_10230	COG0167	dihydroorotate dehydrogenase activity
C2859_10250	COG1012	belongs to the aldehyde dehydrogenase family
C2859_10310	COG2003	Belongs to the UPF0758 family
C2859_10380	COG0758	DNA mediated transformation
C2859_10470	COG2814	Major facilitator Superfamily
C2859_10585	COG1215	transferase activity, transferring glycosyl groups
C2859_10590	COG0726	polysaccharide deacetylase
C2859_10590	COG1649	PFAM Uncharacterised BCR, COG1649
C2859_10665	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C2859_10695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2859_10700	COG0124	histidyl-tRNA synthetase
C2859_10710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2859_10715	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2859_10720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2859_10725	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2859_10725	COG0131	Imidazoleglycerol-phosphate dehydratase
C2859_10730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2859_10735	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2859_10740	COG0107	imidazoleglycerol-phosphate synthase activity
C2859_10745	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2859_10745	COG0140	phosphoribosyl-ATP diphosphatase activity
C2859_10760	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
C2859_10765	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C2859_10770	COG0235	Class ii aldolase
C2859_10775	COG0531	amino acid
C2859_10780	COG0531	amino acid
C2859_10790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2859_10795	COG0277	FAD linked oxidase domain protein
C2859_10815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2859_10860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2859_10865	COG2258	MOSC domain
C2859_10870	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2859_10875	COG0505	Belongs to the CarA family
C2859_10885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2859_10890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2859_10900	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2859_10910	COG3279	Response regulator of the LytR AlgR family
C2859_10920	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2859_10935	COG2198	Histidine kinase
C2859_10935	COG2205	protein histidine kinase activity
C2859_10935	COG0784	Response regulator, receiver
C2859_10940	COG1024	Enoyl-CoA hydratase
C2859_10945	COG0318	PFAM AMP-dependent synthetase and ligase
C2859_10975	COG2267	carboxylic ester hydrolase activity
C2859_10985	COG2201	protein-glutamate methylesterase activity
C2859_10990	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C2859_11000	COG0840	transmembrane signaling receptor activity
C2859_11010	COG0835	chemotaxis
C2859_11030	COG0840	transmembrane signaling receptor activity
C2859_11035	COG0840	transmembrane signaling receptor activity
C2859_11045	COG0840	transmembrane signaling receptor activity
C2859_11055	COG0840	transmembrane signaling receptor activity
C2859_11060	COG0840	transmembrane signaling receptor activity
C2859_11065	COG0840	transmembrane signaling receptor activity
C2859_11070	COG0840	transmembrane signaling receptor activity
C2859_11085	COG0840	transmembrane signaling receptor activity
C2859_11090	COG0840	transmembrane signaling receptor activity
C2859_11105	COG2198	Histidine kinase
C2859_11105	COG0643	Histidine kinase
C2859_11110	COG0745	RESPONSE REGULATOR receiver
C2859_11120	COG0835	chemotaxis
C2859_11125	COG1192	Involved in chromosome partitioning
C2859_11130	COG1360	Flagellar Motor Protein
C2859_11135	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2859_11230	COG0641	radical SAM
C2859_11245	COG2198	Histidine kinase
C2859_11245	COG0643	Histidine kinase
C2859_11265	COG0455	bacterial-type flagellum organization
C2859_11275	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2859_11290	COG3300	MHYT domain
C2859_11290	COG5001	Diguanylate cyclase
C2859_11300	COG3300	MHYT domain
C2859_11300	COG5001	Diguanylate cyclase
C2859_11305	COG1684	flagellar biosynthetic protein fliR
C2859_11310	COG1987	bacterial-type flagellum assembly
C2859_11325	COG3190	flagellar
C2859_11375	COG1677	Flagellar hook-basal body complex protein FliE
C2859_11410	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_11415	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_11420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2859_11435	COG2204	response regulator
C2859_11440	COG2201	protein-glutamate methylesterase activity
C2859_11470	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C2859_11475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2859_11480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2859_11490	COG3951	Flagellar rod assembly protein muramidase FlgJ
C2859_11490	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2859_11495	COG1706	bacterial-type flagellum-dependent cell motility
C2859_11500	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C2859_11505	COG4786	Flagellar basal body rod
C2859_11515	COG4787	bacterial-type flagellum-dependent cell motility
C2859_11520	COG1749	Flagellar hook protein flgE
C2859_11525	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C2859_11530	COG1558	bacterial-type flagellum-dependent cell motility
C2859_11540	COG0784	Response regulator, receiver
C2859_11540	COG0835	chemotaxis
C2859_11560	COG5002	protein histidine kinase activity
C2859_11590	COG2915	High frequency lysogenization protein hflD homolog
C2859_11595	COG0482	sulfurtransferase activity
C2859_11605	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C2859_11610	COG0542	response to heat
C2859_11615	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C2859_11620	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C2859_11630	COG0492	ferredoxin-NADP+ reductase activity
C2859_11635	COG1674	ftsk spoiiie
C2859_11645	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2859_11655	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2859_11660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2859_11670	COG0183	Belongs to the thiolase family
C2859_11675	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2859_11675	COG1024	Enoyl-CoA hydratase
C2859_11685	COG0105	UTP biosynthetic process
C2859_11690	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2859_11700	COG1426	Protein conserved in bacteria
C2859_11710	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2859_11715	COG1160	GTP binding
C2859_11720	COG0303	'Molybdopterin
C2859_11725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2859_11765	COG0708	Exodeoxyribonuclease III
C2859_11775	COG0303	'Molybdopterin
C2859_11780	COG0746	molybdenum cofactor guanylyltransferase activity
C2859_11790	COG1648	precorrin-2 dehydrogenase activity
C2859_11790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2859_11820	COG3685	Protein conserved in bacteria
C2859_11840	COG5001	Diguanylate cyclase
C2859_11850	COG4566	intracellular signal transduction
C2859_11890	COG3275	phosphorelay sensor kinase activity
C2859_11895	COG3279	Response regulator of the LytR AlgR family
C2859_11930	COG1238	metal cluster binding
C2859_11975	COG0653	protein targeting
C2859_11980	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_11985	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C2859_11990	COG1073	alpha beta
C2859_11990	COG2226	methyltransferase
C2859_12040	COG0316	Belongs to the HesB IscA family
C2859_12040	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2859_12045	COG2154	pterin-4-alpha-carbinolamine dehydratase
C2859_12055	COG0428	transporter
C2859_12060	COG3064	Membrane
C2859_12070	COG1530	ribonuclease E activity
C2859_12100	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C2859_12160	COG1192	Involved in chromosome partitioning
C2859_12195	COG0629	single-stranded DNA binding
C2859_12200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2859_12205	COG0270	DNA (cytosine-5-)-methyltransferase activity
C2859_12400	COG0583	DNA-binding transcription factor activity
C2859_12405	COG0477	Major facilitator Superfamily
C2859_12420	COG1960	acyl-CoA dehydrogenase activity
C2859_12430	COG2816	NAD+ diphosphatase activity
C2859_12440	COG2814	Major facilitator Superfamily
C2859_12470	COG0697	spore germination
C2859_12475	COG3830	Belongs to the UPF0237 family
C2859_12475	COG0560	Phosphoserine phosphatase
C2859_12485	COG4221	oxidoreductase activity
C2859_12495	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_12595	COG3593	DNA synthesis involved in DNA repair
C2859_12600	COG1074	ATP-dependent DNA helicase activity
C2859_12610	COG0583	DNA-binding transcription factor activity
C2859_12615	COG1396	sequence-specific DNA binding
C2859_12625	COG0582	viral genome integration into host DNA
C2859_12645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2859_12650	COG0322	excinuclease ABC activity
C2859_12660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2859_12665	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C2859_12670	COG1663	tetraacyldisaccharide 4'-kinase activity
C2859_12675	COG1132	(ABC) transporter
C2859_12685	COG0811	peptide transport
C2859_12700	COG1136	(ABC) transporter
C2859_12705	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2859_12715	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2859_12720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2859_12735	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2859_12760	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2859_12765	COG0837	glucose binding
C2859_12770	COG0363	glucosamine-6-phosphate deaminase activity
C2859_12775	COG0129	dihydroxy-acid dehydratase activity
C2859_12780	COG0800	Aldolase
C2859_12855	COG0784	Response regulator, receiver
C2859_12855	COG2205	protein histidine kinase activity
C2859_12860	COG2183	response to ionizing radiation
C2859_12870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2859_12870	COG0723	plastoquinol--plastocyanin reductase activity
C2859_12885	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2859_12895	COG1183	phosphatidylcholine synthase activity
C2859_12900	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_12915	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2859_12925	COG0668	transmembrane transport
C2859_12930	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C2859_12935	COG0590	tRNA wobble adenosine to inosine editing
C2859_12940	COG1321	iron dependent repressor
C2859_12945	COG1914	H( )-stimulated, divalent metal cation uptake system
C2859_12965	COG2814	Major facilitator Superfamily
C2859_12980	COG1335	isochorismatase
C2859_12995	COG2197	response regulator
C2859_13015	COG0583	DNA-binding transcription factor activity
C2859_13020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2859_13025	COG3002	Belongs to the UPF0753 family
C2859_13030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2859_13120	COG0582	viral genome integration into host DNA
C2859_13125	COG0519	Catalyzes the synthesis of GMP from XMP
C2859_13125	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2859_13135	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2859_13145	COG0475	glutathione-regulated potassium exporter activity
C2859_13145	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2859_13155	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2859_13165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2859_13170	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2859_13180	COG0776	regulation of translation
C2859_13185	COG0539	negative regulation of cytoplasmic translation
C2859_13190	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C2859_13195	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2859_13210	COG2957	Belongs to the agmatine deiminase family
C2859_13215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2859_13240	COG0395	ABC-type sugar transport system, permease component
C2859_13245	COG1175	transmembrane transport
C2859_13275	COG2350	Protein conserved in bacteria
C2859_13280	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C2859_13285	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2859_13290	COG1187	pseudouridine synthase activity
C2859_13310	COG0436	Aminotransferase
C2859_13315	COG4133	protoheme IX ABC transporter activity
C2859_13335	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C2859_13340	COG1138	Cytochrome C-type biogenesis protein
C2859_13360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2859_13365	COG1278	Cold shock
C2859_13370	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2859_13375	COG4988	ABC transporter
C2859_13385	COG1294	oxidase, subunit
C2859_13415	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2859_13420	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2859_13430	COG0165	Argininosuccinate lyase
C2859_13435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2859_13445	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2859_13460	COG0137	argininosuccinate synthase activity
C2859_13465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2859_13475	COG0215	cysteine-tRNA ligase activity
C2859_13480	COG2166	iron-sulfur cluster assembly
C2859_13490	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2859_13495	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2859_13500	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2859_13530	COG4302	ethanolamine ammonia-lyase activity
C2859_13590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2859_13595	COG0402	S-adenosylhomocysteine deaminase activity
C2859_13605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2859_13610	COG1509	lysine 2,3-aminomutase activity
C2859_13615	COG5001	Diguanylate cyclase
C2859_13615	COG3300	MHYT domain
C2859_13630	COG0483	inositol monophosphate 1-phosphatase activity
C2859_13660	COG0513	Belongs to the DEAD box helicase family
C2859_13665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2859_13670	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C2859_13680	COG0625	glutathione transferase activity
C2859_13690	COG4681	YaeQ
C2859_13695	COG2081	HI0933 family
C2859_13705	COG0501	Belongs to the peptidase M48B family
C2859_13710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2859_13715	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_13740	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2859_13745	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2859_13750	COG0802	atpase or kinase
C2859_13755	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2859_13755	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2859_13760	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2859_13765	COG1570	exodeoxyribonuclease VII activity
C2859_13775	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2859_13820	COG0835	chemotaxis
C2859_13825	COG0840	transmembrane signaling receptor activity
C2859_13830	COG2094	Belongs to the DNA glycosylase MPG family
C2859_13835	COG1201	RNA secondary structure unwinding
C2859_13855	COG2969	positive regulation of protein catabolic process
C2859_13860	COG0625	glutathione transferase activity
C2859_13865	COG2857	Cytochrome c1
C2859_13870	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2859_13875	COG0723	plastoquinol--plastocyanin reductase activity
C2859_13885	COG0741	lytic transglycosylase activity
C2859_13900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2859_13905	COG1702	phosphate starvation-inducible protein PhoH
C2859_13915	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2859_13925	COG4535	Mg2 and Co2 transporter CorC
C2859_13940	COG1012	belongs to the aldehyde dehydrogenase family
C2859_13945	COG1177	transmembrane transport
C2859_13950	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2859_13975	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2859_13995	COG0174	glutamine synthetase
C2859_14000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2859_14005	COG3706	GGDEF domain
C2859_14005	COG0745	RESPONSE REGULATOR receiver
C2859_14015	COG0477	Major facilitator Superfamily
C2859_14030	COG0243	molybdopterin cofactor binding
C2859_14035	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2859_14065	COG2733	membrane
C2859_14070	COG5002	protein histidine kinase activity
C2859_14070	COG2205	protein histidine kinase activity
C2859_14070	COG0784	Response regulator, receiver
C2859_14080	COG0477	Major facilitator Superfamily
C2859_14095	COG2902	Dehydrogenase
C2859_14105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2859_14110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2859_14115	COG1609	Transcriptional regulator
C2859_14120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2859_14120	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2859_14125	COG1105	Belongs to the carbohydrate kinase PfkB family
C2859_14130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2859_14130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2859_14155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2859_14165	COG1862	Preprotein translocase
C2859_14170	COG0343	queuine tRNA-ribosyltransferase activity
C2859_14175	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2859_14215	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2859_14220	COG3291	Pkd domain containing protein
C2859_14225	COG0405	Gamma-glutamyltransferase
C2859_14230	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2859_14245	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2859_14250	COG0742	ribosomal rna small subunit methyltransferase
C2859_14255	COG0326	Molecular chaperone. Has ATPase activity
C2859_14375	COG0531	amino acid
C2859_14390	COG0006	proline dipeptidase activity
C2859_14400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2859_14415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2859_14420	COG3938	Belongs to the proline racemase family
C2859_14430	COG0552	protein localization to endoplasmic reticulum
C2859_14440	COG1194	a g-specific adenine glycosylase
C2859_14445	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C2859_14450	COG4191	Histidine kinase
C2859_14450	COG0784	Response regulator, receiver
C2859_14465	COG0322	excinuclease ABC activity
C2859_14480	COG3040	lipid binding
C2859_14495	COG1960	acyl-CoA dehydrogenase activity
C2859_14505	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2859_14525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2859_14530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2859_14535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2859_14570	COG0438	transferase activity, transferring glycosyl groups
C2859_14575	COG0438	transferase activity, transferring glycosyl groups
C2859_14620	COG0776	regulation of translation
C2859_14625	COG0072	phenylalanine-tRNA ligase activity
C2859_14625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2859_14630	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2859_14635	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2859_14640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2859_14645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2859_14650	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2859_14665	COG2211	Major facilitator Superfamily
C2859_14675	COG1082	Xylose isomerase domain protein TIM barrel
C2859_14690	COG0366	Alpha amylase catalytic
C2859_14810	COG3702	type iv secretory pathway
C2859_14830	COG2948	multi-organism process
C2859_14850	COG3505	Type IV secretory pathway VirD4
C2859_14865	COG0556	nucleotide-excision repair
C2859_14910	COG1611	Belongs to the LOG family
C2859_14925	COG2095	MarC family integral membrane protein
C2859_14935	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2859_14940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2859_14970	COG1185	polyribonucleotide nucleotidyltransferase activity
C2859_14975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2859_14980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2859_14985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2859_14990	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C2859_14995	COG0195	Participates in both transcription termination and antitermination
C2859_15000	COG0779	Required for maturation of 30S ribosomal subunits
C2859_15010	COG1007	ATP synthesis coupled electron transport
C2859_15025	COG0713	ATP synthesis coupled electron transport
C2859_15035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2859_15040	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C2859_15050	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C2859_15055	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C2859_15060	COG0649	NAD binding
C2859_15065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2859_15070	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2859_15075	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2859_15090	COG0149	triose-phosphate isomerase activity
C2859_15095	COG0300	oxidoreductase activity
C2859_15125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2859_15130	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2859_15135	COG0159	tryptophan synthase activity
C2859_15145	COG0133	tryptophan synthase activity
C2859_15155	COG0135	phosphoribosylanthranilate isomerase activity
C2859_15160	COG0101	tRNA pseudouridine synthase activity
C2859_15180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2859_15185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2859_15190	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2859_15195	COG2890	protein-(glutamine-N5) methyltransferase activity
C2859_15205	COG0688	phosphatidylethanolamine metabolic process
C2859_15220	COG0433	COG0433 Predicted ATPase
C2859_15225	COG0494	nUDIX hydrolase
C2859_15245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2859_15250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2859_15260	COG2336	PFAM SpoVT AbrB
C2859_15300	COG0420	3'-5' exonuclease activity
C2859_15335	COG0717	Belongs to the dCTP deaminase family
C2859_15345	COG0489	protein tyrosine kinase activity
C2859_15365	COG3590	peptidase
C2859_15375	COG3590	peptidase
C2859_15395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2859_15400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2859_15405	COG2311	Membrane
C2859_15410	COG1047	Peptidyl-prolyl cis-trans
C2859_15415	COG0791	NLP P60 protein
C2859_15420	COG0791	NLP P60 protein
C2859_15430	COG4106	trans-aconitate 2-methyltransferase activity
C2859_15435	COG1301	dicarboxylic acid transport
C2859_15440	COG1785	Belongs to the alkaline phosphatase family
C2859_15450	COG0037	tRNA processing
C2859_15455	COG1722	exodeoxyribonuclease VII activity
C2859_15460	COG0142	geranyltranstransferase activity
C2859_15465	COG4104	PAAR repeat-containing protein
C2859_15475	COG0312	modulator of DNA gyrase
C2859_15480	COG3028	Belongs to the UPF0307 family
C2859_15485	COG0312	modulator of DNA gyrase
C2859_15495	COG3164	Protein of unknown function
C2859_15500	COG1530	ribonuclease E activity
C2859_15505	COG0424	maF-like protein
C2859_15510	COG2968	Membrane
C2859_15525	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2859_15540	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2859_15555	COG0495	leucyl-tRNA aminoacylation
C2859_15565	COG3118	belongs to the thioredoxin family
C2859_15590	COG2155	Conserved Protein
C2859_15595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2859_15635	COG1132	(ABC) transporter
C2859_15665	COG1538	Outer membrane efflux protein
C2859_15670	COG0745	RESPONSE REGULATOR receiver
C2859_15675	COG5002	protein histidine kinase activity
C2859_15675	COG5000	phosphorelay sensor kinase activity
C2859_15680	COG0475	glutathione-regulated potassium exporter activity
C2859_15685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2859_15690	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2859_15715	COG1187	pseudouridine synthase activity
C2859_15720	COG5002	protein histidine kinase activity
C2859_15720	COG5001	Diguanylate cyclase
C2859_15770	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2859_15830	COG2951	lytic endotransglycosylase activity
C2859_15835	COG4644	lycopene metabolic process
C2859_15850	COG2369	cell adhesion
C2859_15900	COG0667	Aldo Keto reductase
C2859_15905	COG2814	Major facilitator Superfamily
C2859_15910	COG0583	DNA-binding transcription factor activity
C2859_15915	COG2207	Transcriptional regulator
C2859_15930	COG0667	Aldo Keto reductase
C2859_15935	COG1309	transcriptional regulator
C2859_15940	COG1538	Outer membrane efflux protein
C2859_15945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2859_15960	COG0735	belongs to the Fur family
C2859_15965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2859_15990	COG4452	Inner membrane protein CreD
C2859_16000	COG2205	protein histidine kinase activity
C2859_16005	COG0745	RESPONSE REGULATOR receiver
C2859_16010	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2859_16025	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2859_16035	COG2198	Histidine kinase
C2859_16035	COG0643	Histidine kinase
C2859_16040	COG0840	transmembrane signaling receptor activity
C2859_16045	COG0835	chemotaxis
C2859_16050	COG2200	EAL domain
C2859_16050	COG2199	diguanylate cyclase activity
C2859_16050	COG2202	Pas domain
C2859_16055	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2859_16060	COG2201	protein-glutamate methylesterase activity
C2859_16065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2859_16070	COG3590	peptidase
C2859_16080	COG0588	phosphoglycerate mutase activity
C2859_16085	COG1515	deoxyribonuclease V activity
C2859_16095	COG1741	Belongs to the pirin family
C2859_16110	COG1741	Belongs to the pirin family
C2859_16115	COG1966	Carbon starvation protein
C2859_16170	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C2859_16175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2859_16180	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2859_16185	COG2080	2 iron, 2 sulfur cluster binding
C2859_16195	COG4251	negative regulation of phosphorylation
C2859_16195	COG5001	Diguanylate cyclase
C2859_16195	COG2203	Gaf domain
C2859_16195	COG3706	GGDEF domain
C2859_16200	COG0629	single-stranded DNA binding
C2859_16205	COG0142	geranyltranstransferase activity
C2859_16215	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2859_16230	COG0527	aspartate kinase activity
C2859_16235	COG0384	phenazine biosynthesis protein PhzF
C2859_16240	COG0384	phenazine biosynthesis protein PhzF
C2859_16250	COG1764	response to oxidative stress
C2859_16255	COG0540	Belongs to the ATCase OTCase family
C2859_16260	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2859_16265	COG1678	Uncharacterized ACR, COG1678
C2859_16275	COG0519	Catalyzes the synthesis of GMP from XMP
C2859_16300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2859_16315	COG0739	heme binding
C2859_16335	COG0693	protein deglycase activity
C2859_16345	COG1959	2 iron, 2 sulfur cluster binding
C2859_16350	COG0719	Fe-S assembly protein
C2859_16355	COG0396	ATPase activity
C2859_16360	COG0719	Fe-S assembly protein
C2859_16365	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2859_16380	COG4774	siderophore transport
C2859_16385	COG3128	pkhd-type hydroxylase
C2859_16410	COG1477	protein flavinylation
C2859_16415	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2859_16430	COG1555	photosystem II stabilization
C2859_16445	COG3178	'Phosphotransferase
C2859_16450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2859_16460	COG0628	permease
C2859_16470	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2859_16480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2859_16500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2859_16505	COG0271	Belongs to the BolA IbaG family
C2859_16515	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2859_16525	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2859_16530	COG1137	ATPase activity
C2859_16545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2859_16550	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C2859_16555	COG1660	Displays ATPase and GTPase activities
C2859_16565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2859_16570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2859_16580	COG2239	Acts as a magnesium transporter
C2859_16595	COG1294	oxidase, subunit
C2859_16600	COG1271	oxidase subunit
C2859_16610	COG1113	amino acid transport
C2859_16640	COG2197	response regulator
C2859_16645	COG0531	amino acid
C2859_16750	COG0754	glutathionylspermidine amidase activity
C2859_16775	COG1842	Phage shock protein A
C2859_16785	COG0259	pyridoxamine-phosphate oxidase activity
C2859_16790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2859_16795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2859_16805	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2859_16810	COG0477	Major facilitator Superfamily
C2859_16830	COG2205	protein histidine kinase activity
C2859_16830	COG2198	Histidine kinase
C2859_16830	COG0784	Response regulator, receiver
C2859_16835	COG2353	YceI-like domain
C2859_16855	COG1760	l-serine dehydratase
C2859_16870	COG0460	homoserine dehydrogenase
C2859_16870	COG0527	aspartate kinase activity
C2859_16875	COG0626	cystathionine gamma-synthase activity
C2859_16880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2859_16885	COG0739	heme binding
C2859_16890	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C2859_16895	COG1272	protein, Hemolysin III
C2859_16900	COG2982	Protein involved in outer membrane biogenesis
C2859_16905	COG0517	IMP dehydrogenase activity
C2859_16905	COG0516	GMP reductase activity
C2859_16910	COG0463	Glycosyl transferase, family 2
C2859_16915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2859_16920	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2859_16930	COG4771	TonB-dependent receptor
C2859_16935	COG1309	transcriptional regulator
C2859_16940	COG2267	carboxylic ester hydrolase activity
C2859_16945	COG1960	acyl-CoA dehydrogenase activity
C2859_16970	COG0509	glycine decarboxylation via glycine cleavage system
C2859_16975	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2859_16995	COG1742	UPF0060 membrane protein
C2859_17000	COG3956	TIGRFAM MazG family protein
C2859_17010	COG0494	nUDIX hydrolase
C2859_17020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2859_17025	COG0837	glucose binding
C2859_17040	COG3858	chitin binding
C2859_17040	COG1388	LysM domain
C2859_17055	COG1472	Belongs to the glycosyl hydrolase 3 family
C2859_17070	COG0531	amino acid
C2859_17080	COG1486	melibiose metabolic process
C2859_17090	COG3537	Alpha-1,2-mannosidase
C2859_17130	COG3142	Participates in the control of copper homeostasis
C2859_17135	COG1446	asparaginase
C2859_17170	COG0840	transmembrane signaling receptor activity
C2859_17175	COG0835	chemotaxis
C2859_17190	COG0189	ligase activity
C2859_17200	COG1397	ADP-ribosylglycohydrolase
C2859_17210	COG1199	ATP-dependent helicase activity
C2859_17220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2859_17225	COG1215	transferase activity, transferring glycosyl groups
C2859_17240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2859_17250	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2859_17255	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C2859_17260	COG0535	radical SAM domain protein
C2859_17265	COG0535	radical SAM domain protein
C2859_17280	COG0837	glucose binding
C2859_17295	COG1643	Atp-dependent helicase
C2859_17300	COG0783	Belongs to the Dps family
C2859_17310	COG0514	ATP-dependent DNA helicase (RecQ)
C2859_17345	COG0840	transmembrane signaling receptor activity
C2859_17365	COG3920	Histidine kinase
C2859_17370	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2859_17380	COG0602	queuosine metabolic process
C2859_17390	COG2885	chlorophyll binding
C2859_17395	COG0823	Involved in the tonB-independent uptake of proteins
C2859_17405	COG0848	biopolymer transport protein
C2859_17415	COG0824	Thioesterase
C2859_17420	COG2255	four-way junction helicase activity
C2859_17430	COG3158	transport of potassium into the cell
C2859_17435	COG0632	four-way junction helicase activity
C2859_17440	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C2859_17445	COG0217	transcriptional regulatory protein
C2859_17460	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2859_17580	COG2951	lytic endotransglycosylase activity
C2859_17595	COG0477	Major facilitator Superfamily
C2859_17640	COG0488	(ABC) transporter
C2859_17680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2859_17680	COG4651	solute:proton antiporter activity
C2859_17705	COG4772	TonB-dependent receptor
C2859_17715	COG4264	IucA IucC family
C2859_17730	COG0019	diaminopimelate decarboxylase activity
C2859_17750	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C2859_17760	COG1492	cobalamin metabolic process
C2859_17770	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C2859_17795	COG4206	TonB-dependent receptor
C2859_17800	COG0542	response to heat
C2859_17805	COG1116	anion transmembrane transporter activity
C2859_17810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2859_17815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2859_17820	COG0667	Aldo Keto reductase
C2859_17830	COG4771	TonB-dependent receptor
C2859_17835	COG2827	Endonuclease containing a URI domain
C2859_17880	COG1877	trehalose-phosphatase activity
C2859_17905	COG0840	transmembrane signaling receptor activity
C2859_17910	COG3011	Protein conserved in bacteria
C2859_17925	COG0564	pseudouridine synthase activity
C2859_17930	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2859_17940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2859_17940	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2859_17950	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2859_17955	COG0045	succinate-CoA ligase (ADP-forming) activity
C2859_18000	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C2859_18005	COG0237	dephospho-CoA kinase activity
C2859_18025	COG5002	protein histidine kinase activity
C2859_18030	COG0745	RESPONSE REGULATOR receiver
C2859_18040	COG0189	ligase activity
C2859_18165	COG3657	addiction module killer protein
C2859_18195	COG3209	COG3209 Rhs family protein
C2859_18245	COG2022	thiamine diphosphate biosynthetic process
C2859_18255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2859_18260	COG3273	potassium ion transport
C2859_18260	COG0471	metal ion transport
C2859_18330	COG2205	protein histidine kinase activity
C2859_18330	COG0784	Response regulator, receiver
C2859_18335	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2859_18350	COG5297	Belongs to the glycosyl hydrolase family 6
C2859_18360	COG3250	beta-galactosidase activity
C2859_18365	COG4948	Mandelate Racemase Muconate Lactonizing
C2859_18380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2859_18390	COG0308	aminopeptidase N
C2859_18395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2859_18405	COG2895	sulfate adenylyltransferase (ATP) activity
C2859_18405	COG0529	Catalyzes the synthesis of activated sulfate
C2859_18410	COG0175	sulfate reduction
C2859_18415	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2859_18420	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2859_18425	COG0175	sulfate reduction
C2859_18465	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2859_18465	COG1648	precorrin-2 dehydrogenase activity
C2859_18480	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C2859_18485	COG3588	fructose-bisphosphate aldolase
C2859_18500	COG0469	pyruvate kinase activity
C2859_18510	COG0126	phosphoglycerate kinase activity
C2859_18535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2859_18545	COG3047	cAMP biosynthetic process
C2859_18550	COG3047	cAMP biosynthetic process
C2859_18560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2859_18560	COG3453	Protein conserved in bacteria
C2859_18565	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2859_18570	COG4149	molybdate abc transporter
C2859_18575	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C2859_18610	COG1376	ErfK ybiS ycfS ynhG family protein
C2859_18615	COG0739	heme binding
C2859_18625	COG4773	Receptor
C2859_18630	COG0596	Alpha beta hydrolase
C2859_18635	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2859_18640	COG1301	dicarboxylic acid transport
C2859_18655	COG2304	oxidoreductase activity
C2859_18675	COG0714	Associated with various cellular activities
C2859_18705	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2859_18720	COG0254	rRNA binding
C2859_18730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2859_18740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2859_18745	COG1758	RNA polymerase activity
C2859_18750	COG0194	GDP metabolic process
C2859_18755	COG1561	YicC-like family, N-terminal region
C2859_18760	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C2859_18770	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2859_18775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2859_18790	COG0006	proline dipeptidase activity
C2859_18800	COG0006	proline dipeptidase activity
C2859_18805	COG3079	Belongs to the UPF0149 family
C2859_18825	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2859_18835	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C2859_18845	COG2912	Transglutaminase-like superfamily
C2859_18850	COG1773	rubredoxin
C2859_18855	COG0352	thiamine-phosphate diphosphorylase activity
C2859_18870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2859_18890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2859_18920	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2859_18925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2859_18935	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_18945	COG0671	phosphoesterase, PA-phosphatase related
C2859_18950	COG3781	membrane
C2859_18960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2859_18965	COG0563	adenylate kinase activity
C2859_18980	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C2859_18990	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C2859_19015	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C2859_19030	COG0840	transmembrane signaling receptor activity
C2859_19035	COG0405	Gamma-glutamyltransferase
C2859_19040	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2859_19060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2859_19070	COG0473	3-isopropylmalate dehydrogenase activity
C2859_19075	COG0066	3-isopropylmalate dehydratase activity
C2859_19080	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2859_19100	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2859_19105	COG1538	Outer membrane efflux protein
C2859_19110	COG1519	Transferase
C2859_19120	COG1560	Kdo2-lipid A biosynthetic process
C2859_19150	COG0281	malic enzyme
C2859_19150	COG0280	phosphate acetyltransferase
C2859_19155	COG1301	dicarboxylic acid transport
C2859_19180	COG0583	DNA-binding transcription factor activity
C2859_19185	COG0667	Aldo Keto reductase
C2859_19200	COG2197	response regulator
C2859_19205	COG1840	ABC-type Fe3 transport system, periplasmic component
C2859_19210	COG0642	Histidine kinase
C2859_19230	COG2851	Citrate transporter
C2859_19235	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_19245	COG2211	Major facilitator Superfamily
C2859_19270	COG1162	GTPase activity
C2859_19305	COG4773	Receptor
C2859_19310	COG0726	polysaccharide deacetylase
C2859_19315	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2859_19330	COG3964	amidohydrolase
C2859_19335	COG0402	S-adenosylhomocysteine deaminase activity
C2859_19360	COG1307	EDD domain protein, DegV family
C2859_19365	COG0242	peptide deformylase activity
C2859_19395	COG0457	Tetratricopeptide repeat
C2859_19400	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2859_19405	COG1215	transferase activity, transferring glycosyl groups
C2859_19410	COG1215	transferase activity, transferring glycosyl groups
C2859_19425	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C2859_19480	COG2188	Transcriptional regulator
C2859_19490	COG1450	Type ii and iii secretion system protein
C2859_19505	COG3166	PFAM Fimbrial assembly family protein
C2859_19510	COG3156	type II secretion system protein K
C2859_19515	COG4795	General secretion pathway protein
C2859_19520	COG2165	general secretion pathway protein
C2859_19525	COG4970	Tfp pilus assembly protein FimT
C2859_19530	COG2165	general secretion pathway protein
C2859_19535	COG1459	type II secretion system
C2859_19540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2859_19545	COG1404	Belongs to the peptidase S8 family
C2859_19550	COG5295	Hep Hag repeat protein
C2859_19555	COG1404	Belongs to the peptidase S8 family
C2859_19560	COG5295	Hep Hag repeat protein
C2859_19570	COG0047	phosphoribosylformylglycinamidine synthase activity
C2859_19570	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2859_19585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2859_19600	COG4974	Belongs to the 'phage' integrase family
C2859_19615	COG0795	lipopolysaccharide-transporting ATPase activity
C2859_19625	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2859_19640	COG0525	valine-tRNA ligase activity
C2859_19670	COG1183	phosphatidylcholine synthase activity
C2859_19680	COG0442	prolyl-tRNA aminoacylation
C2859_19695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2859_19700	COG1127	ABC transporter
C2859_19705	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2859_19705	COG3218	ABC-type transport auxiliary lipoprotein component
C2859_19735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2859_19740	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C2859_19740	COG0662	Cupin 2, conserved barrel domain protein
C2859_19770	COG2086	electron transfer activity
C2859_19785	COG0463	Glycosyl transferase, family 2
C2859_19805	COG2813	Specifically methylates the guanine in position
C2859_19815	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C2859_19820	COG0438	transferase activity, transferring glycosyl groups
C2859_19840	COG0438	transferase activity, transferring glycosyl groups
C2859_19850	COG0626	cystathionine gamma-synthase activity
C2859_19880	COG0625	glutathione transferase activity
C2859_19895	COG0513	Belongs to the DEAD box helicase family
C2859_19905	COG4206	TonB-dependent receptor
C2859_19915	COG0720	synthase
C2859_19925	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2859_19935	COG1956	GAF domain-containing protein
C2859_19945	COG2819	hydrolase of the alpha beta superfamily
C2859_19955	COG0546	phosphoglycolate phosphatase activity
C2859_19960	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2859_19965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2859_19980	COG0339	signal peptide processing
C2859_20035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2859_20040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2859_20045	COG1136	(ABC) transporter
C2859_20045	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2859_20050	COG0577	efflux transmembrane transporter activity
C2859_20065	COG2204	response regulator
C2859_20070	COG4191	Histidine kinase
C2859_20075	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2859_20090	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2859_20095	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2859_20100	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2859_20105	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2859_20110	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2859_20115	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2859_20125	COG0356	it plays a direct role in the translocation of protons across the membrane
C2859_20145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2859_20155	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2859_20195	COG2011	ABC-type metal ion transport system permease component
C2859_20200	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2859_20205	COG0697	spore germination
C2859_20210	COG1666	GTP binding
C2859_20220	COG0784	Response regulator, receiver
C2859_20220	COG2198	Histidine kinase
C2859_20220	COG5002	protein histidine kinase activity
C2859_20245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2859_20255	COG2813	Specifically methylates the guanine in position
C2859_20275	COG2205	protein histidine kinase activity
C2859_20275	COG2202	Pas domain
C2859_20295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2859_20300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2859_20305	COG1522	sequence-specific DNA binding
C2859_20360	COG0842	Transport permease protein
C2859_20365	COG1131	(ABC) transporter
C2859_20370	COG0025	NhaP-type Na H and K H
C2859_20380	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C2859_20385	COG1573	uracil-dna glycosylase
C2859_20395	COG3384	dioxygenase
C2859_20405	COG0583	DNA-binding transcription factor activity
C2859_20415	COG0667	Aldo Keto reductase
C2859_20430	COG3590	peptidase
C2859_20450	COG0531	amino acid
C2859_20465	COG2972	Histidine kinase
C2859_20490	COG3685	Protein conserved in bacteria
C2859_20495	COG3546	catalase activity
C2859_20545	COG1271	oxidase subunit
C2859_20550	COG1294	oxidase, subunit
C2859_20565	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_20570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2859_20590	COG1132	(ABC) transporter
C2859_20605	COG1063	alcohol dehydrogenase
C2859_20680	COG0251	oxidation-reduction process
C2859_20695	COG0840	transmembrane signaling receptor activity
C2859_20710	COG0583	DNA-binding transcription factor activity
C2859_20715	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2859_20760	COG0024	Methionine aminopeptidase
C2859_20860	COG0582	viral genome integration into host DNA
C2859_20890	COG4695	Portal protein
C2859_20935	COG3179	chitinase
C2859_21140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2859_21145	COG1490	D-aminoacyl-tRNA deacylase activity
C2859_21150	COG1560	Kdo2-lipid A biosynthetic process
C2859_21205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2859_21205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2859_21210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2859_21215	COG0242	peptide deformylase activity
C2859_21220	COG1652	LysM domain
C2859_21225	COG0758	DNA mediated transformation
C2859_21245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2859_21245	COG1754	DNA topoisomerase type I activity
C2859_21250	COG0009	L-threonylcarbamoyladenylate synthase
C2859_21265	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_21275	COG0616	signal peptide processing
C2859_21280	COG0534	Mate efflux family protein
C2859_21300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2859_21305	COG0625	glutathione transferase activity
C2859_21320	COG1252	NADH dehydrogenase
C2859_21325	COG2860	membrane
C2859_21330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2859_21335	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2859_21340	COG3437	response regulator, receiver
C2859_21345	COG2177	Part of the ABC transporter FtsEX involved in
C2859_21350	COG2884	Cell division ATP-binding protein ftsE
C2859_21360	COG3118	belongs to the thioredoxin family
C2859_21365	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2859_21370	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C2859_21375	COG0583	DNA-binding transcription factor activity
C2859_21395	COG1652	LysM domain
C2859_21400	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2859_21400	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2859_21405	COG1473	amidohydrolase
C2859_21410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2859_21415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2859_21425	COG5383	Protein conserved in bacteria
C2859_21470	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C2859_21475	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2859_21485	COG4948	Mandelate Racemase Muconate Lactonizing
C2859_21495	COG0531	amino acid
C2859_21510	COG4682	membrane
C2859_21525	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2859_21530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2859_21535	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2859_21540	COG1610	YqeY-like protein
C2859_21550	COG1295	ribonuclease BN
C2859_21555	COG0358	DNA primase activity
C2859_21570	COG0109	protoheme IX farnesyltransferase activity
C2859_21600	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C2859_21615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2859_21660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2859_21665	COG0739	heme binding
C2859_21670	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C2859_21680	COG2211	Major facilitator Superfamily
C2859_21685	COG0708	Exodeoxyribonuclease III
C2859_21690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2859_21700	COG1192	Involved in chromosome partitioning
C2859_21705	COG1475	DNA binding
C2859_21725	COG0463	Glycosyl transferase, family 2
C2859_21745	COG0756	dUTP diphosphatase activity
C2859_21750	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2859_21755	COG2003	Belongs to the UPF0758 family
C2859_21760	COG0018	arginyl-trna synthetase
C2859_21775	COG4221	oxidoreductase activity
C2859_21790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2859_21795	COG1166	arginine decarboxylase activity
C2859_21800	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C2859_21825	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C2859_21825	COG3291	Pkd domain containing protein
C2859_21835	COG0347	Belongs to the P(II) protein family
C2859_21845	COG0606	chelatase, subunit chli
C2859_21860	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2859_21895	COG1690	Belongs to the RtcB family
C2859_21930	COG1090	epimerase
C2859_21935	COG0745	RESPONSE REGULATOR receiver
C2859_21940	COG0642	Histidine kinase
C2859_21970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2859_21995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2859_22000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2859_22015	COG0753	catalase activity
C2859_22030	COG2197	response regulator
C2859_22035	COG4585	Histidine kinase
C2859_22040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2859_22045	COG1136	(ABC) transporter
C2859_22070	COG0697	spore germination
C2859_22090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2859_22095	COG0180	Tryptophanyl-tRNA synthetase
C2859_22100	COG3237	CsbD-like
C2859_22145	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2859_22180	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C2859_22185	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C2859_22185	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C2859_22215	COG2205	protein histidine kinase activity
C2859_22220	COG0745	RESPONSE REGULATOR receiver
C2859_22230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2859_22260	COG1199	ATP-dependent helicase activity
C2859_22275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2859_22335	COG0625	glutathione transferase activity
C2859_22375	COG4555	ABC transporter
C2859_22385	COG1476	TRANSCRIPTIONal
C2859_22430	COG0543	2 iron, 2 sulfur cluster binding
C2859_22430	COG0633	Ferredoxin
C2859_22435	COG1131	(ABC) transporter
C2859_22440	COG0842	Transport permease protein
C2859_22450	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2859_22485	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2859_22495	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2859_22510	COG0045	succinate-CoA ligase (ADP-forming) activity
C2859_22510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2859_22510	COG1042	CoA-binding domain protein
C2859_22515	COG2239	Acts as a magnesium transporter
C2859_22535	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2859_22540	COG3387	PFAM Glycoside hydrolase 15-related
C2859_22555	COG3100	YcgL domain-containing protein
C2859_22560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2859_22570	COG0463	Glycosyl transferase, family 2
C2859_22580	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_22615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2859_22630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2859_22660	COG0823	Involved in the tonB-independent uptake of proteins
C2859_22660	COG4946	Tricorn protease homolog
C2859_22660	COG1506	peptidase
C2859_22680	COG0408	coproporphyrinogen oxidase activity
C2859_22720	COG0515	serine threonine protein kinase
C2859_22720	COG2815	serine threonine protein kinase
C2859_22725	COG0631	protein serine/threonine phosphatase activity
C2859_22760	COG3501	Rhs element vgr protein
C2859_22905	COG0210	DNA helicase
C2859_22920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2859_22925	COG0583	DNA-binding transcription factor activity
C2859_22930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2859_22945	COG2159	amidohydrolase
C2859_22950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2859_22955	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2859_22970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2859_22990	COG0357	Ribosomal RNA small subunit methyltransferase G
C2859_22995	COG3540	Alkaline phosphatase
C2859_23005	COG2091	lysine biosynthetic process via aminoadipic acid
C2859_23020	COG0708	Exodeoxyribonuclease III
C2859_23025	COG1846	Transcriptional regulator
C2859_23025	COG1940	carbohydrate kinase activity
C2859_23035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2859_23045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2859_23050	COG3162	membrane
C2859_23060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2859_23090	COG3507	Belongs to the glycosyl hydrolase 43 family
C2859_23110	COG1028	Short-chain dehydrogenase reductase Sdr
C2859_23115	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2859_23125	COG4948	Mandelate Racemase Muconate Lactonizing
C2859_23130	COG3254	rhamnose metabolic process
C2859_23135	COG0738	Major facilitator superfamily
C2859_23140	COG1414	Transcriptional regulator
C2859_23145	COG1971	Probably functions as a manganese efflux pump
C2859_23150	COG2205	protein histidine kinase activity
C2859_23165	COG3459	Glycosyltransferase 36 associated
C2859_23170	COG2211	Major facilitator Superfamily
C2859_23175	COG3265	gluconokinase activity
C2859_23185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2859_23205	COG2911	Protein conserved in bacteria
C2859_23210	COG0729	surface antigen
C2859_23240	COG0752	glycyl-tRNA synthetase alpha subunit
C2859_23245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2859_23265	COG0519	Catalyzes the synthesis of GMP from XMP
C2859_23265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2859_23275	COG0805	protein transport
C2859_23280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2859_23285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2859_23295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2859_23320	COG2974	May be involved in recombination
C2859_23325	COG0037	tRNA processing
C2859_23335	COG2115	Belongs to the xylose isomerase family
C2859_23345	COG3661	Belongs to the glycosyl hydrolase 67 family
C2859_23355	COG4948	Mandelate Racemase Muconate Lactonizing
C2859_23365	COG1472	Belongs to the glycosyl hydrolase 3 family
C2859_23370	COG0246	Mannitol dehydrogenase
C2859_23420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2859_23450	COG3386	PFAM SMP-30 Gluconolaconase
C2859_23460	COG3250	beta-galactosidase activity
C2859_23465	COG1904	glucuronate isomerase
C2859_23470	COG3693	PFAM glycoside hydrolase, family 10
C2859_23480	COG3693	PFAM glycoside hydrolase, family 10
C2859_23495	COG2211	Major facilitator Superfamily
C2859_23535	COG2937	Belongs to the GPAT DAPAT family
C2859_23570	COG0284	orotidine-5'-phosphate decarboxylase activity
C2859_23575	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C2859_23585	COG3132	Protein of unknown function, DUF480
C2859_23600	COG0210	DNA helicase
C2859_23605	COG1435	thymidine kinase activity
C2859_23615	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C2859_23625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2859_23655	COG3135	benzoate transporter
C2859_23675	COG0676	glucose-6-phosphate 1-epimerase activity
C2859_23685	COG3012	SEC-C Motif Domain Protein
C2859_23690	COG0730	response to heat
C2859_23710	COG0302	gtp cyclohydrolase
C2859_23725	COG1566	PFAM secretion protein HlyD family protein
C2859_23735	COG1289	transmembrane transporter activity
C2859_23740	COG0477	Major facilitator Superfamily
C2859_23750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2859_23770	COG4691	Plasmid stability protein
C2859_23775	COG1487	ribonuclease activity
C2859_23800	COG0564	pseudouridine synthase activity
C2859_23815	COG0439	Biotin carboxylase
C2859_23855	COG1074	ATP-dependent DNA helicase activity
C2859_23860	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2859_23875	COG1127	ABC transporter
C2859_23880	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2859_23885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2859_23900	COG2853	Lipoprotein
C2859_23910	COG0386	Belongs to the glutathione peroxidase family
C2859_23920	COG1322	Protein conserved in bacteria
C2859_23925	COG0604	alcohol dehydrogenase
C2859_23930	COG0583	DNA-binding transcription factor activity
C2859_23945	COG0625	glutathione transferase activity
C2859_23955	COG0531	amino acid
C2859_23960	COG3537	Alpha-1,2-mannosidase
C2859_23975	COG3706	GGDEF domain
C2859_23980	COG3835	regulator
C2859_23985	COG1929	Belongs to the glycerate kinase type-1 family
C2859_23990	COG2271	Major facilitator Superfamily
C2859_24005	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2859_24015	COG0861	Integral membrane protein TerC family
C2859_24030	COG0584	glycerophosphoryl diester phosphodiesterase
C2859_24045	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2859_24050	COG0726	polysaccharide deacetylase
C2859_24055	COG0706	membrane insertase activity
C2859_24060	COG0594	ribonuclease P activity
C2859_24065	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C2859_24095	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2859_24105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain