locus-tag class description FPL05_00060 ENOG4108C33 Resolvase FPL05_00170 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FPL05_00175 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FPL05_00180 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FPL05_00185 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FPL05_00195 ENOG4108K0D peptidase, M48 FPL05_00225 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FPL05_00235 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FPL05_00280 ENOG4105CN1 protease FPL05_00285 ENOG41063SB peptidase FPL05_00295 ENOG4107VAM peptidase, m28 FPL05_00330 ENOG4105DQ4 alcohol dehydrogenase FPL05_00340 ENOG4105BZ8 glutamate synthase FPL05_00345 ENOG4105CBC glutamate synthase FPL05_00375 ENOG4105EXG Transcriptional regulator FPL05_00395 ENOG4105D3Q Sugar transferase FPL05_00400 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FPL05_00410 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family FPL05_00415 ENOG4107RA4 Glycosyl transferase (Group 1 FPL05_00435 ENOG4105CAQ asparagine synthetase FPL05_00450 ENOG4105CMR udp-glucose 4-epimerase FPL05_00465 ENOG4105BZ1 (ABC) transporter FPL05_00495 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) FPL05_00590 ENOG4108I5C dEAD DEAH box helicase FPL05_00595 ENOG4108UT2 hemolysin iii FPL05_00620 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FPL05_00645 ENOG4105DYS nad(p)h dehydrogenase (quinone) FPL05_00655 ENOG41067RQ csbd family FPL05_00675 ENOG4105D4Y metalloprotease FPL05_00700 ENOG4105K63 Thioredoxin FPL05_00710 ENOG4105CSH Transporter FPL05_00750 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FPL05_00780 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 FPL05_00785 ENOG4105CGF Aromatic amino acid aminotransferase FPL05_00790 ENOG4105CHB tonB-dependent Receptor FPL05_00800 ENOG41082W1 Cupin 2, conserved barrel domain protein FPL05_00805 ENOG4105C26 Dehydrogenase FPL05_00830 ENOG4105DMF Dehydrogenase FPL05_00845 ENOG4105BZU Histidine kinase FPL05_00850 ENOG4108S01 response regulator FPL05_00870 ENOG4108M3R transcriptional activator CadC FPL05_00875 ENOG4105RKW reductase (By FPL05_00910 ENOG4108UK2 deaminase FPL05_00955 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) FPL05_00960 ENOG4105CG3 alpha amylase, catalytic region FPL05_00965 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FPL05_00985 ENOG4105EBR Carboxylesterase FPL05_01000 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FPL05_01010 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FPL05_01015 ENOG4105DSG hydrolase family 43 FPL05_01020 ENOG4105ETE Transcriptional regulator (LacI family FPL05_01040 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) FPL05_01045 ENOG4105CHR reductase FPL05_01055 ENOG4107TDE lipolytic protein G-D-S-L family FPL05_01070 ENOG4105MIR Phenylalanine 4-monooxygenase FPL05_01075 ENOG4108YXU transcriptional regulator AsnC family FPL05_01080 ENOG4105CNM Receptor FPL05_01085 ENOG4105D78 K07001 NTE family protein FPL05_01095 ENOG4105DKW ABC transporter FPL05_01110 ENOG4108IJ8 ABC transporter FPL05_01115 ENOG4105E90 ABC transporter FPL05_01145 ENOG4105CAF HipA N-terminal domain protein FPL05_01175 ENOG4105D1F ATP-binding protein FPL05_01180 ENOG4105M4E phosphohistidine phosphatase, SixA FPL05_01190 ENOG4107RZC phospholipase d FPL05_01200 ENOG4105KA0 thioesterase Superfamily protein FPL05_01240 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FPL05_01250 ENOG4105C5F glutamine synthetase FPL05_01260 ENOG4105BZU Histidine kinase FPL05_01265 ENOG4105CUX Signal transduction histidine kinase FPL05_01270 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FPL05_01275 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FPL05_01280 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FPL05_01290 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FPL05_01300 ENOG4105CHU acetyl-coa acetyltransferase FPL05_01335 ENOG4107YZP Rhodanese domain protein FPL05_01340 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) FPL05_01345 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FPL05_01400 ENOG4105D00 flagellar biosynthetic protein flhB FPL05_01405 ENOG4105D7B Flagellar biosynthesis protein flha FPL05_01410 ENOG4108JQA flagellar FPL05_01415 ENOG4105CGA flagellar basal-body rod protein FlgG FPL05_01425 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FPL05_01430 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FPL05_01445 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FPL05_01450 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FPL05_01480 ENOG410822I Flagellar hook capping protein FPL05_01485 ENOG4105BZE flagellar hook protein, FlgE FPL05_01495 ENOG4105DD5 Flagellar motor switch protein FPL05_01505 ENOG4105CN7 Flagellar biosynthetic protein FliP FPL05_01510 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL05_01515 ENOG4105C7K acetolactate synthase FPL05_01520 ENOG4108TQ9 Histidine kinase FPL05_01525 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FPL05_01545 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FPL05_01560 ENOG4105E2T synthase III FPL05_01565 ENOG4107R3N Filamentation induced by cAMP protein fic FPL05_01570 ENOG4108J2P Alpha beta hydrolase fold FPL05_01575 ENOG4105PI0 Ferredoxin FPL05_01580 ENOG410680H amp-dependent synthetase and ligase FPL05_01585 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FPL05_01610 ENOG4105CPF Cell wall formation (By similarity) FPL05_01620 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FPL05_01630 ENOG4105DR9 pseudouridine synthase FPL05_01640 ENOG4108YZN class I peptide chain release factor FPL05_01650 ENOG4105D44 asparaginase FPL05_01655 ENOG4105DGW oligopeptidase A FPL05_01695 ENOG4107R11 Transcriptional regulator FPL05_01700 ENOG4107QP3 malate synthase g FPL05_01710 ENOG4105BZU Histidine kinase FPL05_01740 ENOG4107QX3 carboxylase FPL05_01745 ENOG4105C1G acyl-Coa dehydrogenase FPL05_01800 ENOG4105CKI cobalamin synthesis protein FPL05_01810 ENOG4108TZV Membrane FPL05_01820 ENOG4105D6Z AFG1 family ATPase FPL05_01825 ENOG4105K56 Transcriptional regulator FPL05_01830 ENOG4108ZHJ Organic hydroperoxide resistance protein FPL05_01860 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FPL05_01875 ENOG4108R99 pseudouridine synthase FPL05_01880 ENOG4108KPZ tonB-dependent Receptor FPL05_01890 ENOG4105CQ7 ATP-dependent helicase FPL05_01900 ENOG4108W15 Protein of unknown function (DUF1456) FPL05_01905 ENOG4105VT2 5-hydroxyisourate hydrolase FPL05_01910 ENOG4105E1J oxidoreductase FPL05_01930 ENOG4105C5R Aminotransferase FPL05_01940 ENOG4105EQ2 LysR family Transcriptional regulator FPL05_01945 ENOG4107RTG Major Facilitator superfamily FPL05_01955 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FPL05_01965 ENOG4105DU0 nucleoside hydrolase FPL05_01975 ENOG4105C7N Xanthine uracil vitamin C permease FPL05_01995 ENOG4105ETT transcriptional Regulator, LysR family FPL05_02000 ENOG4105F8V Hydrolase, tatD family FPL05_02015 ENOG4106NZI LysR family Transcriptional regulator FPL05_02020 ENOG4105D94 Major Facilitator Superfamily FPL05_02035 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FPL05_02040 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FPL05_02060 ENOG4105E3W Two component transcriptional regulator (Winged helix family FPL05_02065 ENOG4105EB3 Histidine kinase FPL05_02070 ENOG4105C1P efflux transporter, rnd family, mfp subunit FPL05_02075 ENOG4105BZS acriflavin resistance protein FPL05_02080 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FPL05_02095 ENOG4105WPN DNA integration recombination invertion protein FPL05_02100 ENOG4105DZ2 Transcriptional regulator FPL05_02105 ENOG4108UZX fmn reductase FPL05_02120 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) FPL05_02135 ENOG4105ECR NmrA family FPL05_02230 ENOG4105C01 Dihydroxy-acid dehydratase FPL05_02245 ENOG4108Z0R Transferase FPL05_02255 ENOG4105D2S major facilitator superfamily FPL05_02260 ENOG4105CPI Metal Dependent Phosphohydrolase FPL05_02295 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase FPL05_02305 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FPL05_02310 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FPL05_02315 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FPL05_02320 ENOG4105E98 transcriptional regulator DeoR family FPL05_02345 ENOG4105CHU acetyl-coa acetyltransferase FPL05_02355 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta FPL05_02360 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FPL05_02365 ENOG4105F2Z 3-oxoadipate enol-lactonase FPL05_02370 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FPL05_02385 ENOG4107HP6 Transcriptional regulator FPL05_02400 ENOG4105MH3 Protein of unknown function (DUF2490) FPL05_02405 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FPL05_02440 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FPL05_02445 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FPL05_02455 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FPL05_02460 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FPL05_02465 ENOG41081UC Inherit from COG: Competence protein FPL05_02470 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) FPL05_02535 ENOG4105VS8 Flagellar biosynthetic protein fliq FPL05_02555 ENOG4108HR8 type iii secretion FPL05_02575 ENOG4107Y59 type iii secretion FPL05_02590 ENOG4108JIR Flagellum-specific ATP synthase FPL05_02600 ENOG4108TN6 type iii secretion FPL05_02605 ENOG4105K44 type iii secretion FPL05_02615 ENOG4105FTC Lytic transglycosylase catalytic FPL05_02655 ENOG4105CKW Inner membrane protein yedI FPL05_02660 ENOG4105BZU Histidine kinase FPL05_02665 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FPL05_02670 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FPL05_02675 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FPL05_02700 ENOG4105K4T epimerase FPL05_02705 ENOG4107ZQV short-chain dehydrogenase reductase FPL05_02735 ENOG4105C1J atp-dependent rna helicase FPL05_02740 ENOG4105C7S Dehydrogenase FPL05_02750 ENOG4105CPP Dehydrogenase, E1 component FPL05_02755 ENOG4107RUY (E1 component), alpha subunit FPL05_02765 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FPL05_02770 ENOG4105DUX Transporter FPL05_02785 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FPL05_02790 ENOG4105WDY DNA (cytosine-5-)-methyltransferase FPL05_02795 ENOG4105F1J Homogentisate 1,2-dioxygenase FPL05_02815 ENOG4105KJM monovalent cation h antiporter subunit g FPL05_02820 ENOG4105W4C monovalent cation H antiporter subunit F FPL05_02830 ENOG4107R4Z monovalent cation h antiporter subunit d FPL05_02835 ENOG4108ZE9 Monovalent cation H antiporter subunit C FPL05_02840 ENOG4105D65 subunit l FPL05_02865 ENOG4105NVB glycoside hydrolase, family 19 FPL05_02885 ENOG4105C8V SAICAR synthetase FPL05_02890 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) FPL05_02905 ENOG4105KD7 acetyltransferase FPL05_02910 ENOG4107TE5 Lipid kinase FPL05_02915 ENOG4105CRQ synthase (Component I) FPL05_02925 ENOG4105DDQ anthranilate synthase FPL05_02940 ENOG4108I0Q anthranilate phosphoribosyltransferase FPL05_02945 ENOG4105DK0 Indole-3-glycerol phosphate synthase FPL05_02955 ENOG4107RYR Transcriptional regulator, Crp Fnr family FPL05_02960 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FPL05_02970 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) FPL05_02975 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FPL05_02980 ENOG4108UJD 30S ribosomal protein S9 FPL05_02995 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FPL05_03005 ENOG4108UQY Iron-storage protein FPL05_03010 ENOG4105BZU Histidine kinase FPL05_03035 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FPL05_03055 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FPL05_03070 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) FPL05_03085 ENOG4105EM2 membrane FPL05_03095 ENOG4105C12 Phosphoribosylglycinamide synthetase FPL05_03105 ENOG4105DC1 bifunctional purine biosynthesis protein purh FPL05_03110 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase FPL05_03115 ENOG4105E8V Alpha Beta Hydrolase Fold protein FPL05_03120 ENOG41077RS Phosphatase FPL05_03145 ENOG4108HPI phosphatidate Cytidylyltransferase FPL05_03150 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) FPL05_03180 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FPL05_03205 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FPL05_03215 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FPL05_03220 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FPL05_03225 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FPL05_03230 ENOG4105VF7 tolerance protein FPL05_03245 ENOG4105VV6 START domain-containing protein FPL05_03260 ENOG4105E1F short-chain dehydrogenase reductase FPL05_03265 ENOG4108K8S endonuclease I FPL05_03275 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FPL05_03280 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FPL05_03295 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FPL05_03320 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FPL05_03325 ENOG4105EX9 Membrane FPL05_03345 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) FPL05_03350 ENOG4108YYC ycei family FPL05_03380 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) FPL05_03395 ENOG41065ZS Transfers 2'-(5-triphosphoribosyl)-3'-dephosphocoenzyme- A to the apo- acyl-carrier-protein of the malonate decarboxylase to yield holo- acyl-carrier-protein (By similarity) FPL05_03400 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase FPL05_03415 ENOG4105DRR Transcriptional regulator, GntR family FPL05_03455 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FPL05_03545 ENOG4107GJV short-chain dehydrogenase reductase FPL05_03560 ENOG4105PDP Short chain dehydrogenase FPL05_03570 ENOG4105CHF Glutathione S-transferase FPL05_03590 ENOG4105EYF MMPL domain protein FPL05_03600 ENOG4105C5Z peptidase FPL05_03610 ENOG4107QS8 (LipO)protein FPL05_03620 ENOG4105BZU Histidine kinase FPL05_03640 ENOG4105DFI Membrane FPL05_03645 ENOG4105F87 Dehydratase FPL05_03665 ENOG4105D7N magnesium and cobalt transport protein CorA FPL05_03675 ENOG4105E53 ec 3.2.1.28 FPL05_03725 ENOG4105C8Q Methyl-accepting chemotaxis FPL05_03730 ENOG4106R7G Glycoside hydrolase family 5 FPL05_03735 ENOG4105CHH sulfate transporter FPL05_03745 ENOG4105BZU Histidine kinase FPL05_03765 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) FPL05_03775 ENOG4108HRK Histidine kinase FPL05_03780 ENOG4108NEV two component transcriptional regulator, LytTR family FPL05_03785 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FPL05_03835 ENOG4105WD1 Membrane FPL05_03845 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FPL05_03855 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FPL05_03860 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FPL05_03865 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FPL05_03890 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FPL05_03895 ENOG4105BZU Histidine kinase FPL05_03900 ENOG4105CD8 aminopeptidase N FPL05_03920 ENOG4105DZG Dehydrogenase FPL05_03925 ENOG4108Q1J Extracellular solute-binding protein, family 3 FPL05_03950 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FPL05_03960 ENOG4105DFF Rod shape-determining protein mreb FPL05_03980 ENOG4105CNI cell division protein FtsW FPL05_03990 ENOG4105CVE Lytic murein transglycosylase FPL05_03995 ENOG4105K6T rare lipoprotein A FPL05_04005 ENOG4105DZ1 carboxypeptidase FPL05_04020 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FPL05_04025 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FPL05_04030 ENOG4105CN1 protease FPL05_04040 ENOG4105EGI Transcriptional regulator FPL05_04085 ENOG4108J5G 6-phosphogluconate dehydrogenase FPL05_04090 ENOG4105D9R oxidoreductase FPL05_04095 ENOG4105W4M Transport-associated protein FPL05_04100 ENOG4105BZU Histidine kinase FPL05_04110 ENOG4105BZU Histidine kinase FPL05_04165 ENOG4105GVR general secretion pathway protein D FPL05_04170 ENOG4107QHF type ii secretion system protein e FPL05_04175 ENOG4105D7Q type ii secretion system FPL05_04180 ENOG4108VAU general secretion pathway protein G FPL05_04190 ENOG4105X5Z General secretion pathway protein I FPL05_04200 ENOG4108RTD type II secretion system protein K FPL05_04225 ENOG4105CNT hydrolase family 2 FPL05_04240 ENOG4105FDP GntR family transcriptional regulator FPL05_04250 ENOG4105ETE Transcriptional regulator (LacI family FPL05_04255 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FPL05_04260 ENOG4105CE4 GlcNAc 6-P deacetylase FPL05_04270 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FPL05_04275 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FPL05_04280 ENOG4105C26 Dehydrogenase FPL05_04285 ENOG4105C94 Transporter FPL05_04300 ENOG4108Z33 Thiol disulfide Interchange Protein FPL05_04310 ENOG4106RE7 Cytochrome FPL05_04315 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FPL05_04320 ENOG4105CY0 Metallo-Beta-Lactamase FPL05_04340 ENOG4105JJR Histidine kinase FPL05_04345 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FPL05_04370 ENOG4108QBQ Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione (By similarity) FPL05_04385 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FPL05_04390 ENOG4105JAB phenazine biosynthesis protein, phzf family FPL05_04405 ENOG4105C5H ABC transporter FPL05_04415 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FPL05_04420 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FPL05_04430 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FPL05_04445 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FPL05_04450 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FPL05_04455 ENOG4107YIM Involved in the transcription termination process (By similarity) FPL05_04460 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FPL05_04485 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FPL05_04490 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FPL05_04495 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FPL05_04500 ENOG4105C08 Histidine kinase FPL05_04505 ENOG4105EEX Two component transcriptional regulator (Winged helix family FPL05_04520 ENOG4105CQB FAD linked oxidase domain protein FPL05_04525 ENOG4105S2T inner membrane protein YbcI FPL05_04530 ENOG41082RQ UPF0102 protein FPL05_04565 ENOG4108V6E Cell division protein mraZ FPL05_04570 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FPL05_04575 ENOG4106932 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FPL05_04580 ENOG4105CJN penicillin-binding protein FPL05_04585 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FPL05_04590 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) FPL05_04595 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FPL05_04605 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FPL05_04610 ENOG4105DFU Cell wall formation (By similarity) FPL05_04615 ENOG4105CPF Cell wall formation (By similarity) FPL05_04620 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FPL05_04625 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FPL05_04630 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FPL05_04635 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FPL05_04645 ENOG4105DR5 peptidase FPL05_04650 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FPL05_04655 ENOG4105M6F mutator MutT protein FPL05_04665 ENOG4105SYT Methylenetetrahydrofolate reductase FPL05_04740 ENOG4105DXX methyltransferase FPL05_04745 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FPL05_04755 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FPL05_04790 ENOG4105D6F Phosphatase FPL05_04795 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FPL05_04805 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FPL05_04810 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FPL05_04820 ENOG4108RVA ribokinase FPL05_04825 ENOG4105D9N nucleoside FPL05_04835 ENOG4105CPC Aldo Keto reductase FPL05_04845 ENOG4105D05 Receptor FPL05_04865 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FPL05_04880 ENOG4105E2B Taurine dioxygenase FPL05_04890 ENOG4108I0Y (ABC) transporter FPL05_04895 ENOG4108UJV acyl-CoA thioesterase i FPL05_04900 ENOG4105ETX regulatoR FPL05_04905 ENOG4105DHQ Histidine kinase FPL05_04915 ENOG41080IJ Diacylglycerol kinase FPL05_04935 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FPL05_04940 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FPL05_04955 ENOG4107SM7 Transcriptional regulator FPL05_04960 ENOG4107T8P acyl-Coa dehydrogenase FPL05_04965 ENOG4105D7T ABC transporter FPL05_04970 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FPL05_04980 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FPL05_04985 ENOG4108UZX fmn reductase FPL05_05015 ENOG4105DEF Extracellular solute-binding protein, family 5 FPL05_05025 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FPL05_05035 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FPL05_05040 ENOG4105NWN ApaG protein FPL05_05045 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FPL05_05050 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FPL05_05055 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FPL05_05060 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) FPL05_05070 ENOG4108WBT adenosyltransferase FPL05_05085 ENOG4105D0A hydroxylase FPL05_05090 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FPL05_05125 ENOG4105DDW LysR family Transcriptional regulator FPL05_05140 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase FPL05_05175 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) FPL05_05195 ENOG4105DXC membrane FPL05_05205 ENOG4105CX6 glutaminyL-tRNA synthetase FPL05_05220 ENOG4105BZU Histidine kinase FPL05_05225 ENOG4105BZU Histidine kinase FPL05_05230 ENOG4105WH1 Two component transcriptional regulator luxr family FPL05_05240 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FPL05_05250 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FPL05_05255 ENOG4105NXH GreA GreB family elongation factor FPL05_05265 ENOG4105C5Q Transcriptional regulator FPL05_05280 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FPL05_05300 ENOG4105C2M dna polymerase I FPL05_05330 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FPL05_05350 ENOG4105W8H transhydrogenase (subunit alpha FPL05_05355 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FPL05_05370 ENOG4105CM2 brancheD-chain amino acid aminotransferase FPL05_05375 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FPL05_05380 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FPL05_05385 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FPL05_05390 ENOG4108Z66 YbaK ebsC protein FPL05_05410 ENOG4105CS1 NAD(P)H quinone oxidoreductase FPL05_05415 ENOG4107S2Z UPF0761 membrane protein FPL05_05420 ENOG4107QX9 Thiol disulfide interChange protein FPL05_05435 ENOG4105CSR polyphosphate kinase 2 FPL05_05440 ENOG4108RIR Molybdenum cofactor biosynthesis protein FPL05_05450 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FPL05_05455 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FPL05_05460 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein FPL05_05465 ENOG4105QVB outer membrane lipoprotein LolB FPL05_05470 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FPL05_05480 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FPL05_05485 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FPL05_05490 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FPL05_05495 ENOG4105C3G gtp-binding protein FPL05_05515 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FPL05_05525 ENOG4105PM1 preprotein translocase subunit SecE FPL05_05530 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FPL05_05535 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FPL05_05540 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FPL05_05545 ENOG4108VZM 50s ribosomal protein L10 FPL05_05550 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FPL05_05555 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FPL05_05560 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FPL05_05565 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FPL05_05570 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FPL05_05575 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FPL05_05580 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FPL05_05585 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FPL05_05590 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FPL05_05595 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FPL05_05600 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FPL05_05605 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FPL05_05610 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FPL05_05615 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FPL05_05620 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FPL05_05625 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FPL05_05635 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FPL05_05640 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FPL05_05645 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FPL05_05650 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FPL05_05655 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FPL05_05660 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FPL05_05665 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FPL05_05670 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FPL05_05675 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FPL05_05685 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FPL05_05690 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FPL05_05695 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FPL05_05700 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FPL05_05705 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FPL05_05710 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FPL05_05715 ENOG4108ZT0 50S ribosomal protein l17 FPL05_05720 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) FPL05_05740 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase FPL05_05750 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FPL05_05765 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) FPL05_05770 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FPL05_05775 ENOG4108K3A Glutathione S-transferase FPL05_05795 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FPL05_05800 ENOG4105CIS alcohol dehydrogenase FPL05_05810 ENOG4105CDV Ompa motb domain protein FPL05_05820 ENOG4108R99 pseudouridine synthase FPL05_05830 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FPL05_05835 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FPL05_05840 ENOG4108I5D sulfate abc transporter FPL05_05850 ENOG4108IJ6 ABC transporter FPL05_05860 ENOG4105CPQ Dehydrogenase FPL05_05875 ENOG4105HSS phospholipase C FPL05_05890 ENOG4105CVJ phosphoglycerate mutase FPL05_05895 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FPL05_05910 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FPL05_05915 ENOG4105ED9 Protein of unknown function (DUF455) FPL05_05935 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) FPL05_05940 ENOG4105EYK Phosphatidylglycerophosphatase B FPL05_05945 ENOG4105BZF Glycosyl transferase (Group 1 FPL05_05950 ENOG4105C9X ppx gppa phosphatase FPL05_05955 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FPL05_05960 ENOG4105BZU Histidine kinase FPL05_05965 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL05_05970 ENOG4105ERG peptidase m48, ste24p FPL05_05975 ENOG4105VW4 glutaredoxin 3 FPL05_05985 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FPL05_06165 ENOG4105C2M dna polymerase I FPL05_06475 ENOG4105ED4 portal protein FPL05_06535 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FPL05_06540 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FPL05_06545 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FPL05_06575 ENOG4105EIN peptidylprolyl cis-trans isomerase FPL05_06585 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FPL05_06595 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FPL05_06600 ENOG4107RZZ dna polymerase iii epsilon subunit FPL05_06605 ENOG4108ZF3 Phosphatase FPL05_06620 ENOG4105DKP glycosyl transferase, family 9 FPL05_06625 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) FPL05_06630 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FPL05_06635 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FPL05_06650 ENOG4105M00 molybdopterin converting factor, subunit 1 FPL05_06655 ENOG4108ZAF Molybdopterin FPL05_06670 ENOG4107QMP dna polymerase iii subunits gamma and tau FPL05_06675 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FPL05_06680 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FPL05_06685 ENOG4105K59 histidine triad (HIT) protein FPL05_06695 ENOG4105F8C transglutaminase domain-containing protein FPL05_06705 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FPL05_06715 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 FPL05_06725 ENOG4108UHJ MAF-like protein FPL05_06730 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FPL05_06735 ENOG4105VGS 50s ribosomal protein l32 FPL05_06740 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FPL05_06750 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FPL05_06755 ENOG4105CHR reductase FPL05_06760 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FPL05_06765 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FPL05_06775 ENOG4105HHA aminodeoxychorismate lyase FPL05_06780 ENOG4107QRG dna polymerase iii FPL05_06820 ENOG4108JU7 Transcriptional regulator FPL05_06825 ENOG4105CR4 methylisocitrate lyase FPL05_06830 ENOG4105BZN citrate synthase FPL05_06835 ENOG4108I0Z Aconitate hydratase FPL05_06840 ENOG4105YAJ CopG Arc MetJ FPL05_06855 ENOG4105C7F AcnD-accessory protein PrpF FPL05_06875 ENOG4105DN3 alpha-2-macroglobulin domain protein FPL05_06895 ENOG4108JQB penicillin-binding protein 1C FPL05_06920 ENOG4105M3Z response regulator FPL05_06925 ENOG4107QJR hflk protein FPL05_06930 ENOG4105EPW hflc protein FPL05_06940 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FPL05_06945 ENOG4105CD8 aminopeptidase N FPL05_06950 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FPL05_06955 ENOG4108XFH Transcriptional regulator FPL05_06965 ENOG4108F3G Type I restriction-modification system, R subunit FPL05_06985 ENOG4107QTH restriction modification system DNA specificity domain FPL05_07015 ENOG4105CVJ phosphoglycerate mutase FPL05_07020 ENOG4107Z4K Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FPL05_07030 ENOG4105BZP glycoside hydrolase 15-related FPL05_07035 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FPL05_07045 ENOG4105CWX Alpha-1,2-mannosidase FPL05_07050 ENOG4107JEE Short-chain dehydrogenase reductase Sdr FPL05_07070 ENOG4105C3M thioredoxin reductase FPL05_07095 ENOG4105C7W Xanthine dehydrogenase FPL05_07100 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding FPL05_07105 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit FPL05_07140 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FPL05_07155 ENOG4105C0B DNA polymerase III (alpha subunit) FPL05_07175 ENOG4105EPD Oligopeptide transporter, Opt family FPL05_07190 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FPL05_07210 ENOG4106AXJ AraC family transcriptional regulator FPL05_07235 ENOG4105CV8 reductase FPL05_07240 ENOG4105EBR Carboxylesterase FPL05_07245 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FPL05_07250 ENOG4105C2C drug resistance transporter, Bcr CflA FPL05_07265 ENOG4105DIJ Phosphoethanolamine transferase FPL05_07280 ENOG4105ETX regulatoR FPL05_07285 ENOG4105DHQ Histidine kinase FPL05_07295 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) FPL05_07300 ENOG4107QMS site-determining protein FPL05_07305 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FPL05_07320 ENOG4105BZU Histidine kinase FPL05_07325 ENOG4105WH1 Two component transcriptional regulator luxr family FPL05_07375 ENOG4107SPG Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR FPL05_07385 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate FPL05_07405 ENOG4105C29 acyl-CoA thioesterase FPL05_07420 ENOG4108TGP Thioesterase superfamily protein FPL05_07425 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FPL05_07430 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FPL05_07435 ENOG4105K46 50S ribosomal protein l27 FPL05_07440 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FPL05_07445 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FPL05_07450 ENOG4105CJR Integral membrane protein (MviN FPL05_07455 ENOG4105DTN riboflavin biosynthesis protein ribF FPL05_07460 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FPL05_07465 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FPL05_07470 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FPL05_07480 ENOG4105E2S oxidase) subunit II FPL05_07485 ENOG4105BZ9 Cytochrome C oxidase, subunit I FPL05_07490 ENOG4105CCU oxidase (Subunit III) FPL05_07495 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FPL05_07505 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FPL05_07510 ENOG4105KAF membrAne FPL05_07525 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FPL05_07540 ENOG4107MMM Anti-sigma-factor antagonist FPL05_07545 ENOG4105FUA antagonist FPL05_07550 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase FPL05_07560 ENOG4105BZU Histidine kinase FPL05_07585 ENOG4105KCV RNA signal recognition particle 4.5S RNA FPL05_07590 ENOG4105C08 Histidine kinase FPL05_07595 ENOG4107Z5C methylesterase FPL05_07600 ENOG4105BZU Histidine kinase FPL05_07605 ENOG4105BZU Histidine kinase FPL05_07610 ENOG4105CQZ Histidine kinase FPL05_07625 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) FPL05_07630 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FPL05_07635 ENOG4105CRE cytochrome C FPL05_07640 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FPL05_07645 ENOG4107QWG 2-Nitropropane dioxygenase FPL05_07655 ENOG4105K5M 30s ribosomal protein S16 FPL05_07660 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FPL05_07665 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FPL05_07670 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FPL05_07675 ENOG4107QJQ Mate efflux family protein FPL05_07690 ENOG4105VEJ Heat shock protein FPL05_07695 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FPL05_07705 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FPL05_07745 ENOG4105CNT hydrolase family 2 FPL05_07750 ENOG4106FKC arabinogalactan endo-1,4-beta-galactosidase FPL05_07765 ENOG4105C26 Dehydrogenase FPL05_07770 ENOG4105C1G acyl-Coa dehydrogenase FPL05_07775 ENOG4105E39 Enoyl-CoA hydratase FPL05_07780 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FPL05_07785 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FPL05_07800 ENOG4105EMN RNA polymerase sigma factor FPL05_07810 ENOG4105C0H protease FPL05_07815 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FPL05_07820 ENOG4105C3F Signal peptidase i FPL05_07830 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FPL05_07835 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FPL05_07840 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) FPL05_07850 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FPL05_07860 ENOG41080ZE Adenylate cyclase FPL05_07865 ENOG4107ZXU DSBA oxidoreductase FPL05_07870 ENOG4108QDE fad dependent oxidoreductase FPL05_07875 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein FPL05_07880 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) FPL05_07885 ENOG4108UGV hypoxanthine phosphoribosyltransferase FPL05_07890 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) FPL05_07895 ENOG4105VEQ Cold shock protein FPL05_07915 ENOG4107QRT dEAD DEAH box helicase FPL05_07920 ENOG4107T0X DNA ligase FPL05_07930 ENOG4107T0X DNA ligase FPL05_07945 ENOG4105BZU Histidine kinase FPL05_07960 ENOG4105CHU acetyl-coa acetyltransferase FPL05_07985 ENOG4108VKG metal-dependent hydrolase FPL05_08000 ENOG4105KSC Transcriptional regulator, TraR DksA family FPL05_08015 ENOG4105DFF Rod shape-determining protein mreb FPL05_08020 ENOG4108YZY peptidylprolyl cis-trans isomerase FPL05_08030 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FPL05_08040 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FPL05_08045 ENOG4105F27 Major Facilitator FPL05_08090 ENOG4105M4H endoribonuclease L-psp FPL05_08095 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FPL05_08110 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FPL05_08135 ENOG4105K6V RNA polymerase FPL05_08155 ENOG4108R3D Electron transport complex FPL05_08165 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FPL05_08180 ENOG4105DA5 (ABC) transporter FPL05_08185 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FPL05_08190 ENOG4108IQI permease FPL05_08195 ENOG4107QK5 Homocysteine s-methyltransferase FPL05_08245 ENOG4108YXA Membrane FPL05_08260 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FPL05_08270 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FPL05_08275 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FPL05_08280 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FPL05_08285 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FPL05_08290 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FPL05_08300 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FPL05_08305 ENOG4105DZP Membrane-associated zinc metalloprotease FPL05_08310 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FPL05_08315 ENOG4105KNE Phosphatidate cytidylyltransferase FPL05_08320 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FPL05_08325 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FPL05_08330 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FPL05_08335 ENOG4105BZU Histidine kinase FPL05_08340 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FPL05_08345 ENOG4105CE9 30S ribosomal protein S2 FPL05_08380 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FPL05_08385 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FPL05_08395 ENOG4105KUZ arsenate reductase FPL05_08400 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FPL05_08405 ENOG4105CAQ asparagine synthetase FPL05_08415 ENOG4108ESX Receptor FPL05_08425 ENOG4108UWD Iron-storage protein FPL05_08430 ENOG4105FQ6 thiopurine methyltransferase FPL05_08445 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FPL05_08465 ENOG4105CW7 secretion protein, HlyD family FPL05_08470 ENOG4105C0R drug resistance transporter emrb qaca subfamily FPL05_08490 ENOG4105DUX Transporter FPL05_08520 ENOG4105DGW oligopeptidase A FPL05_08530 ENOG4108V06 Glutathione peroxidase FPL05_08535 ENOG4105DP0 ferredoxin-NADP reductase FPL05_08545 ENOG4107GFK fumarate FPL05_08560 ENOG4105HDD phospholipase FPL05_08570 ENOG4105VEQ Cold shock protein FPL05_08585 ENOG4105CUZ uba thif-type nad fad binding protein FPL05_08590 ENOG4105F8V Hydrolase, tatD family FPL05_08605 ENOG4105C1G acyl-Coa dehydrogenase FPL05_08615 ENOG4108K3A Glutathione S-transferase FPL05_08625 ENOG4105CAQ asparagine synthetase FPL05_08635 ENOG4105CDU Replicative dna helicase FPL05_08640 ENOG4105CVP deoxyribo-dipyrimidine photolyase FPL05_08650 ENOG4105CDV Ompa motb domain protein FPL05_08660 ENOG4105CR8 Transcriptional regulator FPL05_08695 ENOG4105BZU Histidine kinase FPL05_08705 ENOG4106TD9 Diguanylate cyclase FPL05_08740 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FPL05_08745 ENOG4108Z1B Cyclase dehydrase FPL05_08755 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FPL05_08760 ENOG41090R7 Ferric uptake FPL05_08765 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FPL05_08770 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FPL05_08775 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FPL05_08780 ENOG4105CFG Acts as a chaperone (By similarity) FPL05_08785 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FPL05_08795 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) FPL05_08825 ENOG4105C5Q Transcriptional regulator FPL05_08830 ENOG4105BZ1 (ABC) transporter FPL05_08840 ENOG4108URH decarboxylase FPL05_08850 ENOG4105C7S Dehydrogenase FPL05_08855 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FPL05_08865 ENOG4105EZE Cupin 4 family protein FPL05_08875 ENOG4107QTF adenylosuccinate lyase FPL05_08885 ENOG4105C37 (CBS) domain FPL05_08915 ENOG4105CZV ABC transporter FPL05_08920 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FPL05_08935 ENOG4108V1T peptidylprolyl cis-trans isomerase FPL05_08940 ENOG4105C6Y Udp-glucose 6-dehydrogenase FPL05_08945 ENOG41069P5 Protein slyX homolog FPL05_08960 ENOG4105ETE Transcriptional regulator (LacI family FPL05_08970 ENOG4105D7K pfkb domain protein FPL05_08980 ENOG4105C3R Methionine synthase FPL05_08985 ENOG4105C3R Methionine synthase FPL05_08995 ENOG4105C1G acyl-Coa dehydrogenase FPL05_09000 ENOG4105C1G acyl-Coa dehydrogenase FPL05_09005 ENOG4105C1G acyl-Coa dehydrogenase FPL05_09010 ENOG4105C1G acyl-Coa dehydrogenase FPL05_09015 ENOG4105C1G acyl-Coa dehydrogenase FPL05_09035 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FPL05_09045 ENOG4105C2N RNA methyltransferase TrmH family group 3 FPL05_09050 ENOG4105BZU Histidine kinase FPL05_09055 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) FPL05_09065 ENOG4108UTW Plays a role in the regulation of phosphate uptake FPL05_09070 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FPL05_09075 ENOG4105E2Z phosphate ABC transporter (Permease FPL05_09080 ENOG4105C8U phosphate abc transporter FPL05_09085 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) FPL05_09105 ENOG4107B2H carbonic anhydrase FPL05_09110 ENOG4105CHH sulfate transporter FPL05_09115 ENOG4105CSM endonuclease III FPL05_09125 ENOG4105E39 Enoyl-CoA hydratase FPL05_09130 ENOG4108V1T peptidylprolyl cis-trans isomerase FPL05_09135 ENOG4105P8F nudix hydrolase FPL05_09140 ENOG4105KHC sulfurtransferase FPL05_09170 ENOG4105C5H ABC transporter FPL05_09180 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FPL05_09185 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FPL05_09210 ENOG4105CJB Exodeoxyribonuclease I FPL05_09220 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FPL05_09225 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FPL05_09235 ENOG4105C3W Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity) FPL05_09240 ENOG41077A9 carbonic anhydrase FPL05_09285 ENOG4105WH1 Two component transcriptional regulator luxr family FPL05_09325 ENOG4105C5S asparaginyl-tRNA synthetase FPL05_09335 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FPL05_09340 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FPL05_09345 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FPL05_09350 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FPL05_09360 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) FPL05_09370 ENOG4105CIH Imidazole acetol-phosphate transaminase FPL05_09375 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FPL05_09380 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) FPL05_09395 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FPL05_09400 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FPL05_09405 ENOG4105DZG Dehydrogenase FPL05_09420 ENOG4105CGP Urocanate hydratase FPL05_09430 ENOG4105C84 Histidine ammonia-lyase FPL05_09435 ENOG4105CI2 imidazolone-5-propionate hydrolase FPL05_09480 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) FPL05_09485 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) FPL05_09490 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FPL05_09500 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FPL05_09515 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FPL05_09520 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FPL05_09525 ENOG4105CC0 LysR family Transcriptional regulator FPL05_09540 ENOG4105C8Q Methyl-accepting chemotaxis FPL05_09565 ENOG4105BZU Histidine kinase FPL05_09590 ENOG4105KWW Biogenesis protein FPL05_09595 ENOG4107QX9 Thiol disulfide interChange protein FPL05_09600 ENOG4105DA4 cytochrome c-type biogenesis protein FPL05_09605 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) FPL05_09615 ENOG41060IM Heme exporter protein FPL05_09630 ENOG4105EMN RNA polymerase sigma factor FPL05_09685 ENOG4105EGZ biosynthesis protein FPL05_09715 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FPL05_09740 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FPL05_09750 ENOG41079KZ Major Facilitator Superfamily FPL05_09755 ENOG4105DEN Luciferase family FPL05_09785 ENOG4105CJ3 phosphate transporter FPL05_09800 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FPL05_09810 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FPL05_09815 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FPL05_09825 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FPL05_09830 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FPL05_09835 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FPL05_09840 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FPL05_09845 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) FPL05_09850 ENOG4108DG9 Smr protein MutS2 FPL05_09855 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) FPL05_09860 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FPL05_09865 ENOG4108UM1 dedA family FPL05_09870 ENOG4108K5P (LipO)protein FPL05_09885 ENOG4105HBR Rna-binding protein FPL05_09890 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) FPL05_09895 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FPL05_09900 ENOG4105EEI dihydropteroate synthase FPL05_09905 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FPL05_09910 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FPL05_09915 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FPL05_09920 ENOG4107TH8 cina domain protein FPL05_09925 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FPL05_09930 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FPL05_09935 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FPL05_09945 ENOG4105Y3E Modulates RecA activity (By similarity) FPL05_09950 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FPL05_09955 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FPL05_09970 ENOG4107SDU Methyl-accepting chemotaxis FPL05_09980 ENOG4105CWB LysR family transcriptional Regulator FPL05_10020 ENOG4108IAB Phoh family FPL05_10025 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FPL05_10040 ENOG4107TUS Dihydrodipicolinate synthase FPL05_10050 ENOG4108Z4U Ferredoxin FPL05_10055 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 FPL05_10065 ENOG4105CXK mandelate racemase muconate lactonizing FPL05_10070 ENOG4108RTU Aldolase FPL05_10120 ENOG4105CMG Carbohydrate kinase FPL05_10125 ENOG4105C93 Xylose Isomerase FPL05_10150 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase FPL05_10155 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) FPL05_10165 ENOG4105DJ0 Poly(A) Polymerase FPL05_10170 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FPL05_10175 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FPL05_10180 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FPL05_10185 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FPL05_10190 ENOG4107QP8 phosphohexose isomerase FPL05_10235 ENOG4105KU2 hydrolase family 5 FPL05_10240 ENOG4108UYB regulatoR FPL05_10250 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FPL05_10255 ENOG410841Q phosphoesterase PA-phosphatase related protein FPL05_10280 ENOG4108SXK Transporter Drug Metabolite Exporter family FPL05_10285 ENOG4105D4A Cell wall formation (By similarity) FPL05_10290 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FPL05_10310 ENOG4105C26 Dehydrogenase FPL05_10370 ENOG4105W5Q DNA repair protein (RadC FPL05_10445 ENOG4105C79 DNA protecting protein DprA FPL05_10545 ENOG4105EYM Major Facilitator superfamily FPL05_10605 ENOG4108ZXE FPL05_10660 ENOG4105CND Glycosyl transferase, family 2 FPL05_10665 ENOG4107BJW polysaccharide deacetylase FPL05_10755 ENOG4105KAV tspo and mbr like protein FPL05_10790 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FPL05_10795 ENOG4105CUT histidyl-tRNA synthetase FPL05_10805 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FPL05_10810 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FPL05_10815 ENOG4105CIH Imidazole acetol-phosphate transaminase FPL05_10820 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FPL05_10825 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FPL05_10830 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FPL05_10835 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FPL05_10840 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FPL05_10855 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) FPL05_10860 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FPL05_10865 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FPL05_10870 ENOG4105CUB amino acid FPL05_10875 ENOG4105CUB amino acid FPL05_10885 ENOG4108JQ1 Dehydrogenase FPL05_10890 ENOG4105CQB FAD linked oxidase domain protein FPL05_10910 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FPL05_10920 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FPL05_10940 ENOG4105CE1 Ferrous iron transport protein b FPL05_10955 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FPL05_10960 ENOG4108RPX mosc domain containing protein FPL05_10965 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FPL05_10970 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FPL05_10980 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FPL05_10985 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FPL05_10995 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FPL05_11005 ENOG4105DY9 regulatoR FPL05_11015 ENOG4105CRK lysyL-tRNA synthetase FPL05_11020 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FPL05_11025 ENOG4105BZU Histidine kinase FPL05_11030 ENOG4105BZU Histidine kinase FPL05_11035 ENOG4105E39 Enoyl-CoA hydratase FPL05_11040 ENOG4105CEY Amp-dependent synthetase and ligase FPL05_11050 ENOG4107QM5 aconitate hydratase FPL05_11065 ENOG4107QIJ Aconitate hydratase 2 FPL05_11070 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FPL05_11075 ENOG4105BZU Histidine kinase FPL05_11080 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FPL05_11085 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) FPL05_11090 ENOG4105BZU Histidine kinase FPL05_11095 ENOG4105C8Q Methyl-accepting chemotaxis FPL05_11105 ENOG4108V3W Chemotaxis protein, CheW FPL05_11120 ENOG4105C8Q Methyl-accepting chemotaxis FPL05_11125 ENOG4105C8Q Methyl-accepting chemotaxis FPL05_11130 ENOG4105C8Q Methyl-accepting chemotaxis FPL05_11135 ENOG4105C8Q Methyl-accepting chemotaxis FPL05_11140 ENOG4105C8Q Methyl-accepting chemotaxis FPL05_11150 ENOG4105C8Q Methyl-accepting chemotaxis FPL05_11155 ENOG4105C8Q Methyl-accepting chemotaxis FPL05_11160 ENOG4105C8Q Methyl-accepting chemotaxis FPL05_11165 ENOG4105C8Q Methyl-accepting chemotaxis FPL05_11180 ENOG4105C8Q Methyl-accepting chemotaxis FPL05_11185 ENOG4105C8Q Methyl-accepting chemotaxis FPL05_11200 ENOG4105CBS Chea signal transduction histidine kinase FPL05_11205 ENOG4108VYJ response regulator receiver protein FPL05_11215 ENOG4108V3W Chemotaxis protein, CheW FPL05_11220 ENOG4107QJE Chromosome Partitioning Protein FPL05_11225 ENOG4105ER2 Ompa motb domain protein FPL05_11230 ENOG4105E14 MotA TolQ exbB proton channel FPL05_11330 ENOG4105C4X radical SAM domain protein FPL05_11345 ENOG4105CBS Chea signal transduction histidine kinase FPL05_11355 ENOG4108VYJ response regulator receiver protein FPL05_11360 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL05_11365 ENOG4107R21 site-determining protein FPL05_11370 ENOG4105FZW flagellar biosynthesis regulator FlhF FPL05_11375 ENOG4105D7B Flagellar biosynthesis protein flha FPL05_11380 ENOG4105D00 flagellar biosynthetic protein flhB FPL05_11385 ENOG4105BZU Histidine kinase FPL05_11390 ENOG4105BZU Histidine kinase FPL05_11400 ENOG4105BZU Histidine kinase FPL05_11405 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FPL05_11410 ENOG4105VS8 Flagellar biosynthetic protein fliq FPL05_11415 ENOG4105CN7 Flagellar biosynthetic protein FliP FPL05_11420 ENOG4105K0P flagellar biosynthesis protein FPL05_11425 ENOG4105DD5 Flagellar motor switch protein FPL05_11430 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FPL05_11450 ENOG4108JIR Flagellum-specific ATP synthase FPL05_11460 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FPL05_11465 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FPL05_11470 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FPL05_11475 ENOG4107RGC Glycosyl transferase, family 2 FPL05_11480 ENOG4105C74 pyruvyl transferase FPL05_11505 ENOG4105CHR reductase FPL05_11510 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FPL05_11515 ENOG4108P1X synthase FPL05_11530 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FPL05_11535 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FPL05_11540 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL05_11560 ENOG4105MQ3 flagellar protein FliS FPL05_11565 ENOG4107W9T flagellar hook-associated FPL05_11575 ENOG4105DTJ flagellar hook-associated protein FPL05_11585 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FPL05_11590 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FPL05_11595 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FPL05_11600 ENOG4105CGA flagellar basal-body rod protein FlgG FPL05_11610 ENOG4108KPB Flagellar basal-body rod protein FlgF FPL05_11615 ENOG4105BZE flagellar hook protein, FlgE FPL05_11620 ENOG410822I Flagellar hook capping protein FPL05_11625 ENOG4108ZC9 flagellar basal-body rod protein flgc FPL05_11635 ENOG4107R88 Chemotaxis protein (CheV) FPL05_11655 ENOG4105BZU Histidine kinase FPL05_11660 ENOG4105BZU Histidine kinase FPL05_11670 ENOG4105BZU Histidine kinase FPL05_11690 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FPL05_11700 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FPL05_11705 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FPL05_11710 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FPL05_11715 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FPL05_11725 ENOG4105C3M thioredoxin reductase FPL05_11730 ENOG4105CNU cell division protein FtsK FPL05_11740 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) FPL05_11750 ENOG4105D1H recombination factor protein RarA FPL05_11755 ENOG41082MI Protein CrcB homolog FPL05_11765 ENOG4105CHU acetyl-coa acetyltransferase FPL05_11780 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FPL05_11785 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FPL05_11795 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) FPL05_11805 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FPL05_11810 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FPL05_11815 ENOG4105CVM Molybdenum cofactor synthesis domain protein FPL05_11820 ENOG4105D06 uba thif-type nad fad binding protein FPL05_11860 ENOG4105CGK Exodeoxyribonuclease III FPL05_11870 ENOG4105CVM Molybdenum cofactor synthesis domain protein FPL05_11875 ENOG41085AN Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FPL05_11885 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FPL05_11915 ENOG4108N8X transition metal ion binding FPL05_11945 ENOG4108ZXC Two component transcriptional regulator, luxr family FPL05_11985 ENOG4108HRK Histidine kinase FPL05_11990 ENOG4105DY9 regulatoR FPL05_12025 ENOG4105W39 Membrane FPL05_12065 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FPL05_12080 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FPL05_12090 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FPL05_12095 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FPL05_12100 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FPL05_12140 ENOG4105RJZ Transcriptional regulator FPL05_12150 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) FPL05_12155 ENOG41090A4 Pterin carbinolamine dehydratase FPL05_12165 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) FPL05_12170 ENOG4108NST exported protein FPL05_12175 ENOG4105EI2 Pseudouridine synthase FPL05_12180 ENOG4105C03 ribonuclease FPL05_12190 ENOG4105C72 UPF0176 protein FPL05_12200 ENOG4108V1T peptidylprolyl cis-trans isomerase FPL05_12210 ENOG4107QQG Dehydrogenase FPL05_12250 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FPL05_12255 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FPL05_12270 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) FPL05_12275 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FPL05_12280 ENOG4105BZ1 (ABC) transporter FPL05_12295 ENOG4108EC8 DNA internalization-related competence protein ComEC FPL05_12305 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FPL05_12310 ENOG4105D60 lipoprotein releasing system transmembrane protein FPL05_12320 ENOG410681N tpr repeat protein FPL05_12345 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) FPL05_12370 ENOG4105CHC glucokinase (EC 2.7.1.2) FPL05_12375 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) FPL05_12380 ENOG4105C01 Dihydroxy-acid dehydratase FPL05_12385 ENOG4108UHU Aldolase FPL05_12415 ENOG4105N7H Cytochrome FPL05_12465 ENOG4105BZM domain protein FPL05_12490 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class FPL05_12500 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FPL05_12520 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FPL05_12535 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FPL05_12540 ENOG4108Z6B deaminase FPL05_12545 ENOG4105KST dependent repressor FPL05_12550 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FPL05_12570 ENOG4107SFI Major Facilitator superfamily FPL05_12585 ENOG4105CHJ isochorismatase hydrolase FPL05_12600 ENOG4105WH1 Two component transcriptional regulator luxr family FPL05_12620 ENOG4105DND Transcriptional regulator FPL05_12630 ENOG4105EVH UPF0753 protein FPL05_12635 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FPL05_12640 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FPL05_12645 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FPL05_12655 ENOG4105CKD glutathione-regulated potassium-efflux system protein FPL05_12665 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FPL05_12675 ENOG4105ESV Glycosyl transferase, family 4 FPL05_12680 ENOG4105CFV Tetratricopeptide repeat protein FPL05_12690 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FPL05_12695 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FPL05_12700 ENOG4105CAT Cytidine monophosphate kinase FPL05_12705 ENOG4105YK5 50S ribosomal protein L36 FPL05_12720 ENOG4105DWY Agmatine deiminase FPL05_12750 ENOG4105DRS transport system, permease FPL05_12755 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FPL05_12785 ENOG4105K9H YciI-like protein FPL05_12790 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FPL05_12795 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FPL05_12800 ENOG4105FE9 pseudouridine synthase FPL05_12820 ENOG4105CHM Aminotransferase FPL05_12825 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) FPL05_12830 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) FPL05_12835 ENOG41060IM Heme exporter protein FPL05_12845 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) FPL05_12850 ENOG4105DA4 cytochrome c-type biogenesis protein FPL05_12860 ENOG4105KWW Biogenesis protein FPL05_12865 ENOG4108M1T Cytochrome c-type biogenesis protein FPL05_12880 ENOG4108JJ8 (ABC) transporter FPL05_12885 ENOG4108JJ9 ABC, transporter FPL05_12890 ENOG4105C4M (Ubiquinol oxidase) subunit I FPL05_12895 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FPL05_12925 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FPL05_12940 ENOG4105CH7 arginosuccinase FPL05_12945 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FPL05_12955 ENOG4105CAS nag kinase FPL05_12970 ENOG4105CDH Citrulline--aspartate ligase FPL05_12975 ENOG4105DBV ornithine carbamoyltransferase FPL05_12985 ENOG4105C8N cysteinyl-tRNA synthetase FPL05_12990 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FPL05_13000 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters FPL05_13005 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FPL05_13010 ENOG4105CD3 dihydroorotase FPL05_13035 ENOG4105CPD ethanolamine ammonia-lyase FPL05_13040 ENOG4107FQ9 ethanolamine ammonia-lyase FPL05_13100 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FPL05_13105 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FPL05_13110 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FPL05_13120 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FPL05_13125 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FPL05_13130 ENOG4105BZU Histidine kinase FPL05_13145 ENOG4105ECY inositol monophosphatase FPL05_13150 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FPL05_13170 ENOG4105C5H ABC transporter FPL05_13175 ENOG4105C1J atp-dependent rna helicase FPL05_13180 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FPL05_13185 ENOG4105CNG UPF0061 protein FPL05_13195 ENOG4108RXX maleylacetoacetate isomerase FPL05_13200 ENOG4105VEQ Cold shock protein FPL05_13205 ENOG4108VWS Yaeq family FPL05_13210 ENOG4105CBX hi0933 family FPL05_13220 ENOG4105D0M Protease HtpX homolog FPL05_13225 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FPL05_13230 ENOG4105CHR reductase FPL05_13255 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FPL05_13260 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FPL05_13265 ENOG4105K8N protein family UPF0079, ATPase FPL05_13270 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FPL05_13275 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FPL05_13280 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FPL05_13290 ENOG4105E6M Sulphatase-modifying factor protein FPL05_13310 ENOG4105DQE DNA ligase FPL05_13335 ENOG4108V3W Chemotaxis protein, CheW FPL05_13340 ENOG4105C8Q Methyl-accepting chemotaxis FPL05_13345 ENOG4108VX5 3-methyladenine DNA glycosylase FPL05_13350 ENOG4107QRT dEAD DEAH box helicase FPL05_13370 ENOG4105KB2 stringent starvation protein b FPL05_13375 ENOG4107MKT Stringent starvation protein a FPL05_13380 ENOG4105EIX cytochrome c1 FPL05_13385 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FPL05_13390 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FPL05_13400 ENOG4105E4C Lytic transglycosylase catalytic FPL05_13415 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FPL05_13425 ENOG4105C9A Phoh family FPL05_13435 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FPL05_13445 ENOG4108JU5 Magnesium and cobalt efflux protein FPL05_13465 ENOG4105D38 putrescine abc transporter FPL05_13470 ENOG4105F38 ABC transporter, permease FPL05_13495 ENOG4107RUE extracellular solute-binding protein family 1 FPL05_13500 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FPL05_13515 ENOG4105CFQ glutamine synthetase FPL05_13520 ENOG4105CJP fad dependent oxidoreductase FPL05_13525 ENOG4105BZU Histidine kinase FPL05_13530 ENOG4105W3S hemerythrin-like, metal-binding protein FPL05_13535 ENOG4105CSH Transporter FPL05_13550 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit FPL05_13555 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FPL05_13560 ENOG4105FCD Major Facilitator FPL05_13585 ENOG4106BRA Membrane FPL05_13590 ENOG4105BZU Histidine kinase FPL05_13595 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FPL05_13625 ENOG4105C7I Dehydrogenase FPL05_13635 ENOG4105C1P efflux transporter, rnd family, mfp subunit FPL05_13640 ENOG4105BZS acriflavin resistance protein FPL05_13645 ENOG4108M60 Transcriptional regulator FPL05_13650 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FPL05_13655 ENOG4105DE4 1-phosphofructokinase FPL05_13660 ENOG4105DM4 PTS System FPL05_13680 ENOG4107QT7 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FPL05_13685 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FPL05_13690 ENOG4105VIE preprotein translocase, subunit YajC FPL05_13695 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FPL05_13700 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FPL05_13740 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FPL05_13745 ENOG4105E08 Glycoside hydrolase, family 9 FPL05_13750 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FPL05_13755 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FPL05_13770 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FPL05_13775 ENOG4106H78 methyltransferase FPL05_13780 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FPL05_13910 ENOG4107QTZ amino acid FPL05_13925 ENOG4105DC7 peptidase M24 FPL05_13935 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FPL05_13950 ENOG41080HI glycine oxidase FPL05_13955 ENOG4105CTU Proline racemase FPL05_13965 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FPL05_13975 ENOG4105CEN a g-specific adenine glycosylase FPL05_13980 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) FPL05_13985 ENOG4105CQZ Histidine kinase FPL05_14000 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) FPL05_14015 ENOG4105QNF Outer membrane lipoprotein FPL05_14030 ENOG4105CSU acyl-Coa dehydrogenase FPL05_14040 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FPL05_14060 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FPL05_14065 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FPL05_14070 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FPL05_14095 ENOG4108NQK Catalyzes the transfer of a glucuronic acid (GlcA) residue from UDP-glucuronate to mannose-alpha-1,3-glucose-beta- 1,4-glucose-P-P-polyisoprenyl to form the lipid-linked tetrasaccharide GlcA-Man-Glc(2)-PP-Pol, with a glucuronic acid- beta-mannose linkage. Is involved in the biosynthesis of the exopolysaccharide xanthan, since it catalyzes the fourth glycosylation step in the assembly of the pentasaccharide-P-P- polyisoprenyl repeating unit of xanthan. Is unable to use the trisaccharide acceptor freed from the pyrophosphate lipid moiety. Does not show specificity for the lipidic portion of the acceptor. Shows diminished activity when tested with 6-O-acetyl-mannose- alpha-1,3-glucose-beta-1,4-glucose-P-P-polyisoprenyl, a FPL05_14105 ENOG4107Y2G Glycosyl transferase (Group 1 FPL05_14130 ENOG4105D3Q Sugar transferase FPL05_14150 ENOG4105WJX transcriptional regulator MERR family FPL05_14155 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FPL05_14160 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FPL05_14165 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FPL05_14170 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FPL05_14175 ENOG41082NX 50s ribosomal protein l35 FPL05_14180 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FPL05_14185 ENOG4105C22 threonyL-tRNA synthetase FPL05_14190 ENOG4105ETE Transcriptional regulator (LacI family FPL05_14225 ENOG4105CG3 alpha amylase, catalytic region FPL05_14265 ENOG4106E4H Type IV secretory pathway VirB3 family protein FPL05_14285 ENOG4105CMA conjugation trbi family protein FPL05_14320 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FPL05_14355 ENOG4105ED4 portal protein FPL05_14400 ENOG4105NVB glycoside hydrolase, family 19 FPL05_14625 ENOG4105EWT decarboxylase family FPL05_14630 ENOG4108KPZ tonB-dependent Receptor FPL05_14640 ENOG41076UM multiple antibiotic resistance (MarC)-related protein FPL05_14650 ENOG4105M2J Glutaredoxin FPL05_14655 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FPL05_14660 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FPL05_14665 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FPL05_14675 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FPL05_14685 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FPL05_14690 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FPL05_14695 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FPL05_14700 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FPL05_14705 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FPL05_14710 ENOG4105CHV Transcription elongation factor NusA FPL05_14715 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FPL05_14725 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FPL05_14730 ENOG4105C8S subunit m FPL05_14735 ENOG4105D65 subunit l FPL05_14745 ENOG4105DF2 NADH dehydrogenase subunit j FPL05_14750 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FPL05_14755 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FPL05_14760 ENOG4107R0R NADH dehydrogenase subunit g FPL05_14765 ENOG4107QIZ NADH dehydrogenase FPL05_14770 ENOG4105GKE subunit e FPL05_14775 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FPL05_14780 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FPL05_14785 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FPL05_14790 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FPL05_14805 ENOG4105CP7 Triose-phosphate isomerase FPL05_14810 ENOG4107FW0 short-chain dehydrogenase reductase FPL05_14825 ENOG4105BZU Histidine kinase FPL05_14840 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FPL05_14845 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FPL05_14860 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FPL05_14870 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase FPL05_14875 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FPL05_14895 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FPL05_14900 ENOG4105C5I Dehydrogenase FPL05_14905 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FPL05_14910 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FPL05_14920 ENOG4105DJ4 phosphatidylserine decarboxylase FPL05_14935 ENOG4105D7A ATP-binding protein FPL05_14940 ENOG4107VIJ nudix hydrolase FPL05_14960 ENOG4108RRZ Transcription elongation factor GreB FPL05_14965 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) FPL05_14975 ENOG4106A2Z transcriptional regulator antitoxin, MazE FPL05_15015 ENOG4107RH8 nuclease SbcCD subunit D FPL05_15030 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) FPL05_15055 ENOG4105DHP deoxycytidine triphosphate deaminase FPL05_15085 ENOG4105C9K Endothelin-converting enzyme 1 FPL05_15095 ENOG4105C9K Endothelin-converting enzyme 1 FPL05_15115 ENOG4105DC8 reductase FPL05_15120 ENOG4105MWK D-amino acid dehydrogenase, small subunit FPL05_15130 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase FPL05_15135 ENOG4105K4H Nlp p60 protein FPL05_15140 ENOG4105K4H Nlp p60 protein FPL05_15150 ENOG41082K6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FPL05_15160 ENOG4105G6Z alkaline phosphatase FPL05_15170 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FPL05_15175 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FPL05_15180 ENOG4105CTB Polyprenyl synthetase FPL05_15195 ENOG4105CMS peptidase U62, modulator of DNA gyrase FPL05_15200 ENOG4105N42 UPF0307 protein FPL05_15205 ENOG4105D1U peptidase U62 modulator of DNA gyrase FPL05_15215 ENOG4105QD6 exported protein FPL05_15220 ENOG4105C03 ribonuclease FPL05_15225 ENOG4108Z03 MAF-like protein FPL05_15230 ENOG4105MPN Membrane FPL05_15245 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FPL05_15260 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FPL05_15275 ENOG4105C8T Leucyl-tRNA synthetase FPL05_15285 ENOG4107QR8 Thioredoxin FPL05_15310 ENOG4105WG9 Conserved Protein FPL05_15315 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FPL05_15355 ENOG4105BZ1 (ABC) transporter FPL05_15385 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FPL05_15390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL05_15395 ENOG4105BZU Histidine kinase FPL05_15405 ENOG4105FQP Beta-lactamase FPL05_15410 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FPL05_15435 ENOG4105FE9 pseudouridine synthase FPL05_15440 ENOG4105BZU Histidine kinase FPL05_15505 ENOG4105CMQ Chloride channel FPL05_15530 ENOG4105UGU tonB-dependent Receptor FPL05_15550 ENOG4105CVE Lytic murein transglycosylase FPL05_15570 ENOG4108X1T PAAR repeat-containing protein FPL05_15620 ENOG4108FN7 Aldo keto reductase FPL05_15625 ENOG4105F27 Major Facilitator FPL05_15630 ENOG4105CC0 LysR family Transcriptional regulator FPL05_15635 ENOG4105CF7 AraC family transcriptional regulator FPL05_15645 ENOG4105EQ2 LysR family Transcriptional regulator FPL05_15650 ENOG4107SET aldo keto reductase FPL05_15655 ENOG4108JGH Tetr family transcriptional regulator FPL05_15660 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FPL05_15665 ENOG4105BZS acriflavin resistance protein FPL05_15670 ENOG4105C1P efflux transporter, rnd family, mfp subunit FPL05_15680 ENOG4105MYN Zinc uptake regulation protein FPL05_15685 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FPL05_15710 ENOG4105CT7 inner membrane cred family protein FPL05_15725 ENOG4105EB3 Histidine kinase FPL05_15730 ENOG4105E3W Two component transcriptional regulator (Winged helix family FPL05_15735 ENOG4105D6S protein involved in catabolism of external DNA FPL05_15750 ENOG4108JA2 transcriptioN-repair coupling factor FPL05_15760 ENOG4105CBS Chea signal transduction histidine kinase FPL05_15765 ENOG4105C8Q Methyl-accepting chemotaxis FPL05_15770 ENOG4108V3W Chemotaxis protein, CheW FPL05_15775 ENOG4105BZU Histidine kinase FPL05_15780 ENOG4105BZU Histidine kinase FPL05_15785 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FPL05_15790 ENOG4107RZC phospholipase d FPL05_15795 ENOG4105C9K Endothelin-converting enzyme 1 FPL05_15805 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FPL05_15810 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) FPL05_15820 ENOG4105EUB pirin domain protein FPL05_15835 ENOG4105EUB pirin domain protein FPL05_15840 ENOG4105D22 carbon starvation protein FPL05_15845 ENOG4105VCD cytoplasmic protein FPL05_15890 ENOG4107XAN XdhC and CoxI family FPL05_15895 ENOG4105C7W Xanthine dehydrogenase FPL05_15900 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding FPL05_15905 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit FPL05_15920 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FPL05_15925 ENOG4107QTH restriction modification system DNA specificity domain FPL05_15935 ENOG4108F3G Type I restriction-modification system, R subunit FPL05_15975 ENOG4108UUM single-stranded DNA-binding protein FPL05_15980 ENOG4105EAH synthase FPL05_15990 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FPL05_16005 ENOG4105CFH Aspartokinase FPL05_16010 ENOG4105JAB phenazine biosynthesis protein, phzf family FPL05_16015 ENOG4105JAB phenazine biosynthesis protein, phzf family FPL05_16025 ENOG4108Z9K Osmotically inducible protein FPL05_16030 ENOG4105CXT aspartate transcarbamylase FPL05_16035 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FPL05_16040 ENOG4108UJU UPF0301 protein FPL05_16050 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FPL05_16065 ENOG4105CZX twitching motility protein FPL05_16070 ENOG4105CZX twitching motility protein FPL05_16075 ENOG4105DFA alanine racemase domain protein FPL05_16080 ENOG4105II7 pyrroline-5-carboxylate reductase FPL05_16090 ENOG4105FAA peptidase M23 FPL05_16110 ENOG4108Z0Z intracellular protease Pfpi family FPL05_16130 ENOG4105C3K feS assembly ATPase SufC FPL05_16135 ENOG4105JRK feS assembly protein SufD FPL05_16140 ENOG4105C9B Cysteine desulfurase FPL05_16155 ENOG4108IU3 tonb-dependent siderophore receptor FPL05_16160 ENOG4107E2E PKHD-type hydroxylase FPL05_16185 ENOG4105CJ2 (LipO)protein FPL05_16190 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FPL05_16205 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FPL05_16220 ENOG4105EHM Aminoglycoside phosphotransferase FPL05_16225 ENOG4108S0S Nucleotidyl transferase FPL05_16235 ENOG4105C02 permease FPL05_16245 ENOG4105CXB phosphoribosylaminoimidazole synthetase FPL05_16255 ENOG4108V3E phosphoribosylglycinamide formyltransferase FPL05_16285 ENOG4105C2X Arabinose 5-phosphate isomerase FPL05_16290 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase FPL05_16300 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA FPL05_16305 ENOG4108IUZ ABC transporter FPL05_16310 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL05_16315 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA FPL05_16320 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN FPL05_16325 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) FPL05_16330 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FPL05_16340 ENOG41080Z8 PHOSPHOCARRIER protein FPL05_16345 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FPL05_16355 ENOG4105CJW magnesium transporter FPL05_16360 ENOG4107UWA esterase FPL05_16370 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FPL05_16375 ENOG4105C4M (Ubiquinol oxidase) subunit I FPL05_16385 ENOG4105C85 amino acid FPL05_16395 ENOG4108NFF pectate lyase FPL05_16420 ENOG4105CUB amino acid FPL05_16455 ENOG4105QV4 Tryptophan halogenase FPL05_16510 ENOG4108Z4X TRANSCRIPTIONal FPL05_16525 ENOG4106032 Glutathionylspermidine synthase FPL05_16550 ENOG4108P9J Phage shock protein A FPL05_16560 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FPL05_16565 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FPL05_16570 ENOG4105D49 3-dehydroquinate synthase FPL05_16580 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FPL05_16585 ENOG4105C0R drug resistance transporter emrb qaca subfamily FPL05_16590 ENOG4105BZU Histidine kinase FPL05_16595 ENOG4105BZU Histidine kinase FPL05_16605 ENOG4105BZU Histidine kinase FPL05_16610 ENOG4108YYC ycei family FPL05_16630 ENOG4105EJQ L-serine dehydratase FPL05_16645 ENOG4105CFH Aspartokinase FPL05_16650 ENOG4105C28 cystathionine FPL05_16655 ENOG4106TYC homoserine o-acetyltransferase (EC 2.3.1.31) FPL05_16660 ENOG4105DR5 peptidase FPL05_16665 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FPL05_16670 ENOG4108UT2 hemolysin iii FPL05_16675 ENOG41066T0 asmA family FPL05_16680 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FPL05_16690 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase FPL05_16695 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FPL05_16705 ENOG4105D05 Receptor FPL05_16710 ENOG4108IG5 Transcriptional regulator FPL05_16720 ENOG4107QPN acyl-Coa dehydrogenase FPL05_16750 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FPL05_16755 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FPL05_16780 ENOG4105KK4 UPF0060 membrane protein FPL05_16785 ENOG4105DXN mazG family FPL05_16790 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase FPL05_16795 ENOG4107RK2 ADP-ribose diphosphatase NudE FPL05_16805 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FPL05_16810 ENOG4105CHC glucokinase (EC 2.7.1.2) FPL05_16825 ENOG4105VRS hydrolase family 18 FPL05_16855 ENOG4107QTZ amino acid FPL05_16865 ENOG4105F8D glycoside hydrolase family 4 FPL05_16875 ENOG4105CWX Alpha-1,2-mannosidase FPL05_16915 ENOG4106N3A copper homeostasis protein cutc FPL05_16935 ENOG4105D9U N-acetyltransferase FPL05_16950 ENOG4105CBS Chea signal transduction histidine kinase FPL05_16955 ENOG4105C8Q Methyl-accepting chemotaxis FPL05_16960 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis FPL05_16965 ENOG4105M3Z response regulator FPL05_16970 ENOG4108UNF response regulator FPL05_16975 ENOG4105D7Z glutathione synthase FPL05_16985 ENOG41065RQ ADP-ribosylation crystallin J1 FPL05_16990 ENOG41072GX Peptidase M22 Glycoprotease FPL05_16995 ENOG4105DVT helicase FPL05_17005 ENOG4105BZ4 penicillin-binding protein FPL05_17025 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FPL05_17035 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) FPL05_17040 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) FPL05_17045 ENOG4105Z85 coenzyme PQQ synthesis FPL05_17050 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E FPL05_17065 ENOG4105CHC glucokinase (EC 2.7.1.2) FPL05_17080 ENOG4105CQ7 ATP-dependent helicase FPL05_17090 ENOG4105C9U ATP-dependent DNA helicase RecQ FPL05_17125 ENOG4105C8Q Methyl-accepting chemotaxis FPL05_17145 ENOG410903D sensor protein FPL05_17150 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FPL05_17390 ENOG4105ED4 portal protein FPL05_17430 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FPL05_17440 ENOG4105KCK Peptidoglycan-associated lipoprotein FPL05_17445 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) FPL05_17455 ENOG4105M8F Biopolymer transport protein exbD tolR FPL05_17460 ENOG4105E02 MotA TolQ exbB proton channel FPL05_17465 ENOG4107YD3 Thioesterase FPL05_17470 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FPL05_17480 ENOG4105DFH Transport of potassium into the cell (By similarity) FPL05_17485 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FPL05_17490 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FPL05_17495 ENOG4105CDY transcriptional regulatory protein FPL05_17510 ENOG4105C9M aspartyl-trna synthetase FPL05_17580 ENOG4108NSC Pfam:DUF88 FPL05_17605 ENOG4108NSC Pfam:DUF88 FPL05_17650 ENOG4105CVE Lytic murein transglycosylase FPL05_17665 ENOG4108ISG Major Facilitator FPL05_17675 ENOG4105HSS phospholipase C FPL05_17695 ENOG4105ETT transcriptional Regulator, LysR family FPL05_17705 ENOG4105C5H ABC transporter FPL05_17710 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FPL05_17725 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FPL05_17730 ENOG4107RNH Outer membrane receptor FepA FPL05_17745 ENOG4105CKD glutathione-regulated potassium-efflux system protein FPL05_17770 ENOG4105GAV receptor FPL05_17795 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FPL05_17815 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FPL05_17820 ENOG4108YZT Adenosylcobinamide kinase FPL05_17825 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FPL05_17830 ENOG4105EFT decarboxylase FPL05_17835 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FPL05_17840 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FPL05_17860 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FPL05_17865 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FPL05_17870 ENOG4105E2Y ABC, transporter FPL05_17875 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FPL05_17880 ENOG4105GVF (ABC) transporter FPL05_17885 ENOG4105CPC Aldo Keto reductase FPL05_17890 ENOG4105CPU Monooxygenase FPL05_17895 ENOG4107ZSV Receptor FPL05_17905 ENOG41082IR Excinuclease ABC C subunit domain protein FPL05_17940 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FPL05_17950 ENOG4108K4C ec 3.1.3.12 FPL05_17960 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase FPL05_17965 ENOG4105DZG Dehydrogenase FPL05_17975 ENOG4105C8Q Methyl-accepting chemotaxis FPL05_17980 ENOG4105KIR Thiol-disulfide oxidoreductase dcc FPL05_17995 ENOG4105C34 Pseudouridine synthase FPL05_18000 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FPL05_18010 ENOG4105C4K Nad synthetase FPL05_18020 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FPL05_18025 ENOG4105CMV Succinyl-CoA synthetase subunit beta FPL05_18030 ENOG4107TUY Histidine kinase FPL05_18035 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FPL05_18055 ENOG4107QHF type ii secretion system protein e FPL05_18070 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) FPL05_18075 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FPL05_18095 ENOG4105BZU Histidine kinase FPL05_18100 ENOG4105ETX regulatoR FPL05_18110 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FPL05_18220 ENOG4105VUH addiction module killer protein FPL05_18250 ENOG4105CNA YD repeat protein FPL05_18300 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FPL05_18310 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FPL05_18335 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FPL05_18345 ENOG4105ETE Transcriptional regulator (LacI family FPL05_18360 ENOG4105EUR Domain-Containing protein FPL05_18380 ENOG4105BZU Histidine kinase FPL05_18385 ENOG4108M8H domain protein FPL05_18400 ENOG41065HY 1,4-beta-cellobiosidase FPL05_18430 ENOG4105EIB trna rrna methyltransferase FPL05_18440 ENOG4105CD8 aminopeptidase N FPL05_18445 ENOG4105BZS acriflavin resistance protein FPL05_18455 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) FPL05_18460 ENOG4105C11 sulfate adenylyltransferase), subunit 2 FPL05_18465 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FPL05_18470 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FPL05_18475 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FPL05_18495 ENOG4105BZU Histidine kinase FPL05_18510 ENOG4107R11 Transcriptional regulator FPL05_18515 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FPL05_18530 ENOG4108UVJ appr-1-p processing domain protein FPL05_18535 ENOG4107R1Y fructose-bisphosphate aldolase FPL05_18550 ENOG4105CA9 Pyruvate kinase FPL05_18560 ENOG4105BZA Phosphoglycerate kinase FPL05_18585 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FPL05_18595 ENOG4105EIF outer membrane protein W FPL05_18600 ENOG4105EIF outer membrane protein W FPL05_18610 ENOG4107S76 domain protein FPL05_18615 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FPL05_18620 ENOG4105E0C molybdate abc transporter FPL05_18625 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) FPL05_18660 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein FPL05_18665 ENOG4105DR5 peptidase FPL05_18675 ENOG4105CNM Receptor FPL05_18680 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FPL05_18685 ENOG4105CV1 Transketolase (EC 2.2.1.1) FPL05_18690 ENOG4105CK2 sodium dicarboxylate symporter FPL05_18700 ENOG4107QVM von Willebrand factor, type A FPL05_18720 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FPL05_18725 ENOG4105E4G Type IV pilus FPL05_18750 ENOG4108JQC penicillin-binding protein 1A FPL05_18765 ENOG4105NRA 50s ribosomal protein l31 type b FPL05_18770 ENOG4105DU0 nucleoside hydrolase FPL05_18775 ENOG4105CB5 ATP-dependent DNA helicase recG FPL05_18780 ENOG4105KME endoribonuclease L-psp FPL05_18785 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FPL05_18790 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FPL05_18795 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FPL05_18800 ENOG4105DSJ YicC domain protein FPL05_18805 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FPL05_18815 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FPL05_18820 ENOG4105CSA Coproporphyrinogen iii oxidase FPL05_18835 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) FPL05_18845 ENOG4107RAQ aminopeptidase FPL05_18860 ENOG4105W8B Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) FPL05_18870 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FPL05_18880 ENOG4105E66 phosphoriboisomerase A FPL05_18890 ENOG41063JG Transcriptional regulator FPL05_18895 ENOG4105VCQ rubredoxin FPL05_18900 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FPL05_18910 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FPL05_18915 ENOG41061ZR Transcriptional regulator FPL05_18930 ENOG4105CIH Imidazole acetol-phosphate transaminase FPL05_18960 ENOG4105C8Y Acetylornithine aminotransferase FPL05_18965 ENOG4105EYW Ion transport protein FPL05_18985 ENOG410841Q phosphoesterase PA-phosphatase related protein FPL05_18990 ENOG4105FFC UPF0187 protein FPL05_19000 ENOG4105DFU Cell wall formation (By similarity) FPL05_19005 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FPL05_19030 ENOG4105F0N pyrophosphate phospho-hydrolase FPL05_19045 ENOG4105ECQ AraC Family Transcriptional Regulator FPL05_19055 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FPL05_19075 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FPL05_19080 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FPL05_19095 ENOG4105C7B Threonine dehydratase FPL05_19100 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FPL05_19110 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FPL05_19115 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FPL05_19120 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FPL05_19125 ENOG4108MP6 LysR family Transcriptional regulator FPL05_19140 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FPL05_19145 ENOG4105DFG type I secretion outer membrane protein FPL05_19150 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FPL05_19160 ENOG4105D1S lipid A biosynthesis FPL05_19190 ENOG4105C6K Malic enzyme FPL05_19195 ENOG4105CK2 sodium dicarboxylate symporter FPL05_19210 ENOG4105CSH Transporter FPL05_19220 ENOG4105F04 LysR family Transcriptional regulator FPL05_19225 ENOG4105CPC Aldo Keto reductase FPL05_19240 ENOG4105WH1 Two component transcriptional regulator luxr family FPL05_19245 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC FPL05_19250 ENOG4105DHQ Histidine kinase FPL05_19270 ENOG4105D4T Citrate transporter FPL05_19275 ENOG4105CHR reductase FPL05_19295 ENOG4107QW3 Sucrose phosphorylase FPL05_19310 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FPL05_19345 ENOG4105CNM Receptor FPL05_19370 ENOG41069H0 dihydroorotase EC 3.5.2.3 FPL05_19375 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FPL05_19400 ENOG4108RMV DegV Family FPL05_19405 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FPL05_19440 ENOG4105EJG cellulose synthase FPL05_19445 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) FPL05_19450 ENOG4107EEX Cellulose synthase regulator protein FPL05_19455 ENOG4107QZ7 Cellulose synthase catalytic subunit FPL05_19470 ENOG4107RH7 Nicotinate phosphoribosyltransferase FPL05_19525 ENOG4106S9K Transcriptional regulator FPL05_19545 ENOG4105GVR general secretion pathway protein D FPL05_19555 ENOG410678M general secretion pathway protein M FPL05_19560 ENOG41090VX general secretion pathway protein L FPL05_19565 ENOG4105UV2 general secretion pathway protein K FPL05_19570 ENOG41069G9 General secretion pathway protein J FPL05_19580 ENOG4105WMT general secretion pathway protein h FPL05_19590 ENOG4105D7Q type ii secretion system FPL05_19600 ENOG4107QHF type ii secretion system protein e FPL05_19605 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FPL05_19610 ENOG4105EUR Domain-Containing protein FPL05_19615 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FPL05_19620 ENOG4105EUR Domain-Containing protein FPL05_19630 ENOG4108ETH Formylglycinamide ribotide synthetase FPL05_19645 ENOG4105T95 Thiol disulfide interChange protein FPL05_19660 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FPL05_19675 ENOG4108K5H permease YjgP YjgQ family protein FPL05_19685 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FPL05_19700 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FPL05_19730 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FPL05_19740 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FPL05_19745 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS FPL05_19760 ENOG4105DHJ ABC, transporter FPL05_19765 ENOG4108SNX Mammalian cell entry related domain protein FPL05_19780 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FPL05_19795 ENOG4107QKV phosphomannomutase FPL05_19800 ENOG4105CJT Mannose-1-phosphate guanylyltransferase FPL05_19810 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FPL05_19815 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FPL05_19830 ENOG4105BZJ Electron transfer flavoprotein FPL05_19835 ENOG4105C10 Electron transfer flavoprotein FPL05_19875 ENOG4108DMA Nad-dependent epimerase dehydratase FPL05_19880 ENOG4105C0K Gdp-mannose 4,6-dehydratase FPL05_19885 ENOG4105CGN Glycosyl transferase (Group 1 FPL05_19895 ENOG4105EY8 ABC transporter FPL05_19915 ENOG4105C28 cystathionine FPL05_19940 ENOG4105CZX twitching motility protein FPL05_19945 ENOG4108RXX maleylacetoacetate isomerase FPL05_19960 ENOG4105C1J atp-dependent rna helicase FPL05_19970 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FPL05_19980 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FPL05_19990 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FPL05_20010 ENOG4105NIV Esterase FPL05_20015 ENOG4107RNH Outer membrane receptor FepA FPL05_20020 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FPL05_20025 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FPL05_20030 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) FPL05_20045 ENOG4105DGW oligopeptidase A FPL05_20100 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FPL05_20105 ENOG4105DJY efflux transporter, rnd family, mfp subunit FPL05_20110 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FPL05_20115 ENOG4107RBB ABC transporter, permease FPL05_20130 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FPL05_20135 ENOG4105BZU Histidine kinase FPL05_20140 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FPL05_20155 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FPL05_20160 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FPL05_20165 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FPL05_20170 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FPL05_20175 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FPL05_20180 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FPL05_20185 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FPL05_20190 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) FPL05_20210 ENOG4107QN2 dihydrolipoyl dehydrogenase FPL05_20220 ENOG4107QSN dihydrolipoamide acetyltransferase FPL05_20255 ENOG4105D01 (LipO)protein FPL05_20260 ENOG4108UMI ABC transporter, permease FPL05_20265 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FPL05_20270 ENOG4108EHX EamA-like transporter family FPL05_20275 ENOG4108VPT UPF0234 protein FPL05_20285 ENOG4105BZU Histidine kinase FPL05_20305 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FPL05_20310 ENOG4107YBY Hydrolase FPL05_20315 ENOG4105I08 Pseudouridine synthase FPL05_20320 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FPL05_20340 ENOG4105BZU Histidine kinase FPL05_20360 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FPL05_20365 ENOG4105MWK D-amino acid dehydrogenase, small subunit FPL05_20370 ENOG4105EW9 transcriptional regulator AsnC family FPL05_20390 ENOG4107RD7 Flagellar Motor Protein, MotA FPL05_20395 ENOG4105ER2 Ompa motb domain protein FPL05_20420 ENOG4105E3A (ABC) transporter FPL05_20425 ENOG4105DA5 (ABC) transporter FPL05_20430 ENOG4105EEQ Na H antiporter FPL05_20445 ENOG4108UN4 phage SPO1 DNA polymerase-related protein FPL05_20455 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FPL05_20465 ENOG4105CBN LysR family transcriptional regulator FPL05_20475 ENOG4105CPC Aldo Keto reductase FPL05_20490 ENOG4105C9K Endothelin-converting enzyme 1 FPL05_20510 ENOG4107QTZ amino acid FPL05_20520 ENOG4108VAC response regulator FPL05_20525 ENOG4105C2F Histidine kinase FPL05_20550 ENOG4108Z9Z response to DNA damage stimulus FPL05_20555 ENOG4105WEF catalase FPL05_20575 ENOG4105BZU Histidine kinase FPL05_20590 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FPL05_20605 ENOG4105C4M (Ubiquinol oxidase) subunit I FPL05_20610 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FPL05_20625 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FPL05_20630 ENOG4105CMR udp-glucose 4-epimerase FPL05_20650 ENOG4105BZ1 (ABC) transporter FPL05_20665 ENOG4105E2A Dehydrogenase FPL05_20725 ENOG4105CIG ABC transporter FPL05_20740 ENOG4108UQ8 endoribonuclease L-psp FPL05_20770 ENOG4105HEI LysR family (Transcriptional regulator FPL05_20775 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FPL05_20945 ENOG4105ED4 portal protein FPL05_20990 ENOG4105NVB glycoside hydrolase, family 19 FPL05_21195 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL05_21200 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FPL05_21205 ENOG4105D1S lipid A biosynthesis FPL05_21215 ENOG4108Z7F N-acetyltransferase FPL05_21260 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FPL05_21265 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FPL05_21270 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FPL05_21275 ENOG4108WZM domain protein FPL05_21280 ENOG4105C79 DNA protecting protein DprA FPL05_21285 ENOG4108RPN Protein smg homolog FPL05_21300 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FPL05_21305 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FPL05_21320 ENOG4107ZQV short-chain dehydrogenase reductase FPL05_21335 ENOG4105D07 Signal peptide peptidase, SppA FPL05_21340 ENOG4107QI1 Mate efflux family protein FPL05_21360 ENOG4105C25 Primosomal protein n' FPL05_21365 ENOG4108TGY Glutathione S-transferase FPL05_21385 ENOG4105EN6 Membrane FPL05_21390 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL05_21395 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FPL05_21400 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FPL05_21405 ENOG4105CRP Part of the ABC transporter FtsEX involved in FPL05_21410 ENOG4105CAK Cell division ATP-binding protein ftsE FPL05_21415 ENOG4105C1J atp-dependent rna helicase FPL05_21420 ENOG4105K63 Thioredoxin FPL05_21425 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FPL05_21430 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) FPL05_21435 ENOG4105ETT transcriptional Regulator, LysR family FPL05_21445 ENOG4105E9K Isocitrate dehydrogenase FPL05_21455 ENOG4109066 lysm domain bon superfamily protein FPL05_21460 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FPL05_21465 ENOG4105CH2 amidohydrolase FPL05_21470 ENOG4105ENT Efflux transporter rnd family, mfp subunit FPL05_21475 ENOG4105BZS acriflavin resistance protein FPL05_21485 ENOG4105E32 cytoplasmic protein FPL05_21530 ENOG4108UQS dipeptidase FPL05_21535 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FPL05_21545 ENOG4105DTQ mandelate racemase muconate lactonizing FPL05_21555 ENOG4105D5Q Arginine ornithine antiporter FPL05_21570 ENOG4108Z12 YiaAB two helix domain-containing protein FPL05_21580 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FPL05_21585 ENOG4107ZVW dihydroneopterin aldolase FPL05_21590 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FPL05_21595 ENOG4105VCC 30S ribosomal protein S21 FPL05_21600 ENOG4105KTH gatB Yqey FPL05_21610 ENOG4107S2Z UPF0761 membrane protein FPL05_21615 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FPL05_21620 ENOG4105DHU Bile acid FPL05_21630 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FPL05_21655 ENOG4107QS1 Cytochrome C Oxidase, Subunit III FPL05_21660 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) FPL05_21675 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) FPL05_21685 ENOG4105C26 Dehydrogenase FPL05_21720 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FPL05_21725 ENOG4105DR5 peptidase FPL05_21730 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FPL05_21740 ENOG4105EYM Major Facilitator superfamily FPL05_21745 ENOG4105CGK Exodeoxyribonuclease III FPL05_21750 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FPL05_21760 ENOG4107QJE Chromosome Partitioning Protein FPL05_21765 ENOG4105FA0 parb-like partition protein FPL05_21785 ENOG4105CKK Glycosyl transferase, family 2 FPL05_21805 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FPL05_21810 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FPL05_21815 ENOG4105W5Q DNA repair protein (RadC FPL05_21820 ENOG4105C75 arginyL-tRNA synthetase FPL05_21835 ENOG4105EMU Dehydrogenase FPL05_21850 ENOG4105CEY Amp-dependent synthetase and ligase FPL05_21855 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) FPL05_21860 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FPL05_21885 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 FPL05_21895 ENOG4108YZA Nitrogen regulatory protein pii FPL05_21900 ENOG4105W0Z cytoplasmic protein FPL05_21905 ENOG4105C0P Mg chelatase subunit ChlI FPL05_21920 ENOG41066DG (EAL) domain protein FPL05_21935 ENOG4105EJ2 Transcriptional regulator FPL05_21955 ENOG4105E0Y RtcB Protein FPL05_21990 ENOG4105ECP epimerase FPL05_21995 ENOG4105XJC Two component transcriptional regulator (Winged helix family FPL05_22000 ENOG4105DHQ Histidine kinase FPL05_22030 ENOG4105C0H protease FPL05_22050 ENOG4105DSF transport protein FPL05_22055 ENOG4107URF beta-phospho-glucomutase FPL05_22060 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FPL05_22075 ENOG4107VGR Catalase FPL05_22090 ENOG4108S01 response regulator FPL05_22095 ENOG4108ZGX Histidine kinase FPL05_22100 ENOG4105ENT Efflux transporter rnd family, mfp subunit FPL05_22105 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FPL05_22130 ENOG4105FDR Membrane FPL05_22150 ENOG4108NNI Beta-lactamase domain-containing protein FPL05_22155 ENOG4105C31 Tryptophanyl-tRNA synthetase FPL05_22160 ENOG4105VDW Csbd family FPL05_22245 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase FPL05_22275 ENOG4105EB3 Histidine kinase FPL05_22280 ENOG4105XJC Two component transcriptional regulator (Winged helix family FPL05_22290 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FPL05_22310 ENOG4105CH6 catalase FPL05_22320 ENOG4105DVT helicase FPL05_22335 ENOG4105E2X shikimate dehydrogenase FPL05_22370 ENOG4105D52 delta-aminolevulinic acid dehydratase FPL05_22400 ENOG4105CYM Glutathione S-transferase FPL05_22425 ENOG4105QV4 Tryptophan halogenase FPL05_22440 ENOG4108IUW ABC transporter FPL05_22450 ENOG4105VZ8 Transcriptional regulator FPL05_22470 ENOG4105PGM cation diffusion facilitator family transporter FPL05_22480 ENOG4105E0K tonB-dependent siderophore receptor FPL05_22490 ENOG4105ECQ AraC Family Transcriptional Regulator FPL05_22495 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein FPL05_22500 ENOG4105DA5 (ABC) transporter FPL05_22505 ENOG4105E3A (ABC) transporter FPL05_22515 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FPL05_22550 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FPL05_22560 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FPL05_22575 ENOG4105CD5 CoA-binding domain protein FPL05_22580 ENOG4105CJW magnesium transporter FPL05_22600 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FPL05_22605 ENOG4105BZP glycoside hydrolase 15-related FPL05_22625 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FPL05_22635 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FPL05_22680 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FPL05_22685 ENOG4105E9Q Acyl-transferase FPL05_22695 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FPL05_22725 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FPL05_22745 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) FPL05_22755 ENOG4105C2M dna polymerase I FPL05_22785 ENOG4105D9P serine threonine protein kinase FPL05_22790 ENOG4108ZF3 Phosphatase FPL05_22890 ENOG4105EUR Domain-Containing protein FPL05_22945 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FPL05_22975 ENOG4108WC9 type VI secretion system effector, hcp1 family FPL05_23005 ENOG4105C4R Atp-dependent dna helicase FPL05_23020 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FPL05_23025 ENOG4108KB2 LysR family Transcriptional regulator FPL05_23030 ENOG4105JSC dimethylmenaquinone methyltransferase FPL05_23045 ENOG4105KHM amidohydrolase 2 FPL05_23050 ENOG4105W0E 50S ribosomal protein L33 FPL05_23055 ENOG4105KDC 50s ribosomal protein l28 FPL05_23070 ENOG4105ENT Efflux transporter rnd family, mfp subunit FPL05_23090 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FPL05_23095 ENOG4105DGI Alkaline phosphatase FPL05_23120 ENOG4105CGK Exodeoxyribonuclease III FPL05_23125 ENOG4105E2R ROK family FPL05_23135 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FPL05_23145 ENOG4107QN1 sodium solute FPL05_23150 ENOG41062QD Membrane FPL05_23160 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FPL05_23190 ENOG4105DSG hydrolase family 43 FPL05_23210 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr FPL05_23215 ENOG4105ERH Fumarylacetoacetate hydrolase FPL05_23225 ENOG4105DIA mandelate racemase muconate lactonizing FPL05_23230 ENOG4105QJH Domain of unknown function (DUF718) FPL05_23235 ENOG4105EDR glucose galactose transporter FPL05_23240 ENOG4108K2P TRANSCRIPTIONal FPL05_23245 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) FPL05_23250 ENOG4105BZU Histidine kinase FPL05_23265 ENOG4105E2V Glycosyltransferase 36 FPL05_23270 ENOG4105CT4 transporter FPL05_23275 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FPL05_23305 ENOG4105MA0 exported protein FPL05_23310 ENOG4105CFU surface antigen FPL05_23335 ENOG4108JJA ABC, transporter FPL05_23340 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FPL05_23345 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FPL05_23350 ENOG4107QHF type ii secretion system protein e FPL05_23375 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FPL05_23385 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FPL05_23390 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FPL05_23405 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FPL05_23430 ENOG4105DH7 May be involved in recombination (By similarity) FPL05_23435 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) FPL05_23445 ENOG4105C93 Xylose Isomerase FPL05_23450 ENOG4105ETE Transcriptional regulator (LacI family FPL05_23455 ENOG4105D0H Alpha-glucuronidase (EC 3.2.1.139) FPL05_23465 ENOG4105CXK mandelate racemase muconate lactonizing FPL05_23480 ENOG4105DEI Mannitol dehydrogenase FPL05_23530 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FPL05_23565 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) FPL05_23570 ENOG4105CNT hydrolase family 2 FPL05_23575 ENOG4105D2H Uronic isomerase FPL05_23605 ENOG4105CT4 transporter FPL05_23610 ENOG4105DT9 hydrolase family 43 FPL05_23645 ENOG4105E55 glycerol-3-phosphate acyltransferase FPL05_23660 ENOG4105ETE Transcriptional regulator (LacI family FPL05_23675 ENOG4105QV4 Tryptophan halogenase FPL05_23680 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FPL05_23685 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FPL05_23695 ENOG4108YXG UPF0502 protein FPL05_23705 ENOG4105KNA -acetyltransferase FPL05_23710 ENOG4105C4R Atp-dependent dna helicase FPL05_23715 ENOG4107104 thymidine kinase FPL05_23720 ENOG4105BZU Histidine kinase FPL05_23725 ENOG4105DJ9 glucan biosynthesis protein FPL05_23735 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FPL05_23765 ENOG4105DKK Benzoate FPL05_23785 ENOG4105DSB aldose 1-epimerase FPL05_23795 ENOG4105K5B UPF0225 protein FPL05_23800 ENOG4105EJ9 Membrane FPL05_23820 ENOG4105EUJ GTP cyclohydrolase i FPL05_23830 ENOG4105ZQC membrane protein AaeX FPL05_23835 ENOG4105Y49 secretion protein, HlyD family FPL05_23845 ENOG4105DR8 Membrane FPL05_23850 ENOG4105CSH Transporter FPL05_23860 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FPL05_23935 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FPL05_23975 ENOG4107QKA exodeoxyribonuclease V beta FPL05_23980 ENOG4105DSY exodeoxyribonuclease V, gamma FPL05_23995 ENOG4105DHJ ABC, transporter FPL05_24000 ENOG4105CY3 ABC transporter, permease FPL05_24005 ENOG4107PE3 Mammalian cell entry related domain protein FPL05_24020 ENOG410903C (LipO)protein FPL05_24030 ENOG4108V06 Glutathione peroxidase FPL05_24040 ENOG4107QSV RmuC domain protein FPL05_24045 ENOG4105CIS alcohol dehydrogenase FPL05_24050 ENOG4105EJC lysr family transcriptional regulator FPL05_24065 ENOG4108TGY Glutathione S-transferase FPL05_24075 ENOG4105CUB amino acid FPL05_24080 ENOG4105CWX Alpha-1,2-mannosidase FPL05_24090 ENOG4105NRM Membrane FPL05_24095 ENOG4105BZU Histidine kinase FPL05_24100 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FPL05_24105 ENOG4105BZW Glycerate kinase FPL05_24110 ENOG4105CSP Major Facilitator Superfamily FPL05_24125 ENOG4105DR4 Methyltransferase FPL05_24135 ENOG4105DU1 integral membrane protein, terc FPL05_24150 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FPL05_24165 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FPL05_24170 ENOG4108ZJ4 polysaccharide deacetylase FPL05_24175 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FPL05_24180 ENOG41067YR RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)