locus-tag	class	description
A9D66_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A9D66_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A9D66_00020	COG0187	DNA topoisomerase II activity
A9D66_00030	COG0501	Belongs to the peptidase M48B family
A9D66_00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A9D66_00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A9D66_00115	COG0793	Belongs to the peptidase S41A family
A9D66_00120	COG4942	peptidase
A9D66_00130	COG2234	aminopeptidase activity
A9D66_00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A9D66_00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A9D66_00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A9D66_00160	COG1064	alcohol dehydrogenase
A9D66_00165	COG0493	'glutamate synthase
A9D66_00170	COG0067	glutamate synthase
A9D66_00170	COG0069	glutamate synthase activity
A9D66_00170	COG0070	glutamate synthase
A9D66_00215	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A9D66_00230	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A9D66_00235	COG0438	transferase activity, transferring glycosyl groups
A9D66_00235	COG0297	glycogen (starch) synthase activity
A9D66_00255	COG0367	asparagine synthase
A9D66_00285	COG1132	(ABC) transporter
A9D66_00400	COG1205	dead DEAH box helicase
A9D66_00400	COG1111	helicase
A9D66_00405	COG1272	protein, Hemolysin III
A9D66_00430	COG1028	Short-chain dehydrogenase reductase Sdr
A9D66_00450	COG2249	NAD(P)H dehydrogenase (quinone) activity
A9D66_00460	COG3237	CsbD-like
A9D66_00510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A9D66_00515	COG0477	Major facilitator Superfamily
A9D66_00555	COG0714	Associated with various cellular activities
A9D66_00585	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A9D66_00595	COG4772	TonB-dependent receptor
A9D66_00605	COG0662	Cupin 2, conserved barrel domain protein
A9D66_00610	COG1012	belongs to the aldehyde dehydrogenase family
A9D66_00635	COG1304	FMN binding
A9D66_00650	COG4585	Histidine kinase
A9D66_00655	COG2197	response regulator
A9D66_00675	COG3710	Transcriptional regulator
A9D66_00680	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A9D66_00740	COG0366	Alpha amylase catalytic
A9D66_00745	COG0366	Alpha amylase catalytic
A9D66_00750	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A9D66_00770	COG2755	lipolytic protein G-D-S-L family
A9D66_00770	COG0657	acetylesterase activity
A9D66_00780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A9D66_00795	COG3507	Belongs to the glycosyl hydrolase 43 family
A9D66_00800	COG1609	Transcriptional regulator
A9D66_00805	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A9D66_00810	COG1028	Short-chain dehydrogenase reductase Sdr
A9D66_00820	COG2755	lipolytic protein G-D-S-L family
A9D66_00835	COG3186	Phenylalanine-4-hydroxylase
A9D66_00840	COG1522	sequence-specific DNA binding
A9D66_00850	COG1752	Esterase of the alpha-beta hydrolase superfamily
A9D66_00860	COG1119	ATPase activity
A9D66_00875	COG1125	glycine betaine transport
A9D66_00890	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A9D66_00910	COG3550	peptidyl-serine autophosphorylation
A9D66_00915	COG1396	sequence-specific DNA binding
A9D66_00940	COG0489	protein tyrosine kinase activity
A9D66_00945	COG2062	phosphohistidine phosphatase, SixA
A9D66_00955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A9D66_01000	COG1968	undecaprenyl-diphosphatase activity
A9D66_01005	COG0174	glutamine synthetase
A9D66_01010	COG0347	Belongs to the P(II) protein family
A9D66_01015	COG0004	ammonium transporteR
A9D66_01020	COG3852	Histidine kinase
A9D66_01025	COG2204	response regulator
A9D66_01030	COG2032	superoxide dismutase activity
A9D66_01035	COG2032	superoxide dismutase activity
A9D66_01045	COG0346	lactoylglutathione lyase activity
A9D66_01055	COG0183	Belongs to the thiolase family
A9D66_01090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A9D66_01095	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A9D66_01100	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A9D66_01155	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A9D66_01160	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A9D66_01165	COG4786	Flagellar basal body rod
A9D66_01170	COG4786	Flagellar basal body rod
A9D66_01185	COG1706	bacterial-type flagellum-dependent cell motility
A9D66_01200	COG1677	Flagellar hook-basal body complex protein FliE
A9D66_01205	COG1766	The M ring may be actively involved in energy transduction
A9D66_01220	COG1157	protein secretion by the type III secretion system
A9D66_01235	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A9D66_01270	COG0028	Belongs to the TPP enzyme family
A9D66_01275	COG2205	protein histidine kinase activity
A9D66_01300	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A9D66_01315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A9D66_01325	COG0596	Alpha beta hydrolase
A9D66_01335	COG0318	PFAM AMP-dependent synthetase and ligase
A9D66_01340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A9D66_01360	COG1181	Belongs to the D-alanine--D-alanine ligase family
A9D66_01370	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A9D66_01380	COG0564	pseudouridine synthase activity
A9D66_01400	COG1446	asparaginase
A9D66_01405	COG0339	signal peptide processing
A9D66_01440	COG0475	glutathione-regulated potassium exporter activity
A9D66_01445	COG0583	DNA-binding transcription factor activity
A9D66_01450	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A9D66_01455	COG2224	Isocitrate lyase
A9D66_01460	COG3706	GGDEF domain
A9D66_01490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A9D66_01495	COG1960	acyl-CoA dehydrogenase activity
A9D66_01550	COG0523	cobalamin synthesis protein
A9D66_01565	COG0697	spore germination
A9D66_01575	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A9D66_01580	COG1846	Transcriptional regulator
A9D66_01585	COG1764	response to oxidative stress
A9D66_01615	COG2130	NADP-dependent
A9D66_01630	COG1187	pseudouridine synthase activity
A9D66_01645	COG1643	Atp-dependent helicase
A9D66_01655	COG4807	Protein conserved in bacteria
A9D66_01660	COG2351	hydroxyisourate hydrolase activity
A9D66_01665	COG2072	flavoprotein involved in K transport
A9D66_01685	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A9D66_01720	COG1957	nucleoside hydrolase
A9D66_01730	COG2252	PERMEase
A9D66_01755	COG0084	hydrolase, TatD family'
A9D66_01770	COG0583	DNA-binding transcription factor activity
A9D66_01775	COG2814	Major facilitator Superfamily
A9D66_01790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A9D66_01795	COG1902	pentaerythritol trinitrate reductase activity
A9D66_01815	COG0745	RESPONSE REGULATOR receiver
A9D66_01820	COG2205	protein histidine kinase activity
A9D66_01825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9D66_01835	COG1538	Outer membrane efflux protein
A9D66_01850	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A9D66_01855	COG0583	DNA-binding transcription factor activity
A9D66_01895	COG0702	epimerase
A9D66_01900	COG1733	regulation of RNA biosynthetic process
A9D66_01910	COG2801	Transposase and inactivated derivatives
A9D66_01915	COG2963	transposase activity
A9D66_01930	COG2801	Transposase and inactivated derivatives
A9D66_01935	COG2963	transposase activity
A9D66_01950	COG2801	Transposase and inactivated derivatives
A9D66_01955	COG2963	transposase activity
A9D66_01970	COG2801	Transposase and inactivated derivatives
A9D66_01975	COG2963	transposase activity
A9D66_01985	COG0129	dihydroxy-acid dehydratase activity
A9D66_02005	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A9D66_02060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A9D66_02065	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A9D66_02090	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A9D66_02095	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A9D66_02105	COG3485	protocatechuate 3,4-dioxygenase
A9D66_02110	COG3485	protocatechuate 3,4-dioxygenase
A9D66_02120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A9D66_02125	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A9D66_02135	COG1414	Transcriptional regulator
A9D66_02155	COG0445	tRNA wobble uridine modification
A9D66_02195	COG2267	carboxylic ester hydrolase activity
A9D66_02205	COG0156	8-amino-7-oxononanoate synthase activity
A9D66_02210	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A9D66_02215	COG1040	competence protein
A9D66_02220	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A9D66_02295	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A9D66_02380	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A9D66_02385	COG2354	Protein conserved in bacteria
A9D66_02390	COG0745	RESPONSE REGULATOR receiver
A9D66_02390	COG3706	GGDEF domain
A9D66_02395	COG0297	glycogen (starch) synthase activity
A9D66_02400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A9D66_02405	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A9D66_02430	COG0702	epimerase
A9D66_02435	COG1028	Short-chain dehydrogenase reductase Sdr
A9D66_02460	COG0513	Belongs to the DEAD box helicase family
A9D66_02465	COG0508	dehydrogenase complex catalyzes the overall conversion of
A9D66_02480	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A9D66_02490	COG3483	tryptophan 2,3-dioxygenase activity
A9D66_02495	COG3104	oligopeptide transport
A9D66_02515	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A9D66_02530	COG1320	monovalent cation:proton antiporter activity
A9D66_02535	COG2212	antiporter activity
A9D66_02545	COG0651	ATP synthesis coupled electron transport
A9D66_02550	COG1006	Multisubunit Na H antiporter MnhC subunit
A9D66_02555	COG2111	Na H antiporter
A9D66_02555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A9D66_02575	COG3179	chitinase
A9D66_02600	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A9D66_02605	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A9D66_02620	COG0456	acetyltransferase
A9D66_02625	COG1597	lipid kinase activity
A9D66_02650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A9D66_02655	COG0134	indole-3-glycerol-phosphate synthase activity
A9D66_02665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A9D66_02670	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A9D66_02680	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
A9D66_02685	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A9D66_02690	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A9D66_02705	COG1051	belongs to the nudix hydrolase family
A9D66_02745	COG0316	Belongs to the HesB IscA family
A9D66_02765	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A9D66_02780	COG2814	Major facilitator Superfamily
A9D66_02790	COG2814	Major facilitator Superfamily
A9D66_02795	COG1289	transmembrane transporter activity
A9D66_02805	COG0151	Belongs to the GarS family
A9D66_02815	COG0138	bifunctional purine biosynthesis protein purh
A9D66_02820	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A9D66_02825	COG2267	carboxylic ester hydrolase activity
A9D66_02830	COG2453	phosphatase
A9D66_02830	COG0671	phosphoesterase, PA-phosphatase related
A9D66_02855	COG4589	Belongs to the CDS family
A9D66_02860	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A9D66_02885	COG2264	protein methyltransferase activity
A9D66_02900	COG0439	Biotin carboxylase
A9D66_02910	COG0511	ligase activity, forming carbon-carbon bonds
A9D66_02915	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A9D66_02925	COG1324	tolerance protein
A9D66_02950	COG0300	oxidoreductase activity
A9D66_02955	COG2356	endonuclease I
A9D66_02965	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A9D66_02970	COG0459	protein refolding
A9D66_02985	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A9D66_03000	COG3386	PFAM SMP-30 Gluconolaconase
A9D66_03010	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A9D66_03015	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A9D66_03035	COG0778	Nitroreductase
A9D66_03040	COG2353	YceI-like domain
A9D66_03070	COG3052	prosthetic group binding
A9D66_03090	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A9D66_03105	COG1802	Transcriptional regulator
A9D66_03210	COG4221	oxidoreductase activity
A9D66_03225	COG4221	oxidoreductase activity
A9D66_03235	COG0435	Glutathione S-transferase
A9D66_03255	COG2409	Drug exporters of the RND superfamily
A9D66_03260	COG0823	Involved in the tonB-independent uptake of proteins
A9D66_03260	COG1506	peptidase
A9D66_03270	COG3706	GGDEF domain
A9D66_03310	COG1113	amino acid transport
A9D66_03320	COG0598	Magnesium transport protein CorA
A9D66_03330	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
A9D66_03365	COG5001	Diguanylate cyclase
A9D66_03370	COG0840	transmembrane signaling receptor activity
A9D66_03375	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A9D66_03375	COG5297	Belongs to the glycosyl hydrolase family 6
A9D66_03380	COG0659	secondary active sulfate transmembrane transporter activity
A9D66_03385	COG3706	GGDEF domain
A9D66_03395	COG2943	transferase activity, transferring hexosyl groups
A9D66_03405	COG3275	phosphorelay sensor kinase activity
A9D66_03415	COG0181	hydroxymethylbilane synthase activity
A9D66_03440	COG1505	serine-type exopeptidase activity
A9D66_03460	COG2832	Protein of unknown function (DUF454)
A9D66_03470	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A9D66_03480	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A9D66_03485	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A9D66_03490	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A9D66_03515	COG2226	methyltransferase
A9D66_03520	COG5001	Diguanylate cyclase
A9D66_03520	COG3300	MHYT domain
A9D66_03525	COG0308	aminopeptidase N
A9D66_03575	COG3284	Transcriptional regulator
A9D66_03585	COG1077	Cell shape determining protein MreB Mrl
A9D66_03590	COG1792	Involved in formation and maintenance of cell shape
A9D66_03605	COG0772	Belongs to the SEDS family
A9D66_03615	COG2951	lytic endotransglycosylase activity
A9D66_03620	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A9D66_03630	COG1686	Belongs to the peptidase S11 family
A9D66_03640	COG2921	Belongs to the UPF0250 family
A9D66_03645	COG0321	lipoyl(octanoyl) transferase activity
A9D66_03650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A9D66_03665	COG0583	DNA-binding transcription factor activity
A9D66_03675	COG1056	cytidyltransferase-related domain
A9D66_03675	COG1051	belongs to the nudix hydrolase family
A9D66_03710	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A9D66_03715	COG0673	inositol 2-dehydrogenase activity
A9D66_03720	COG2823	Periplasmic or secreted lipoprotein
A9D66_03725	COG4251	negative regulation of phosphorylation
A9D66_03730	COG0784	Response regulator, receiver
A9D66_03735	COG4191	Histidine kinase
A9D66_03740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A9D66_03800	COG1459	type II secretion system
A9D66_03820	COG4795	General secretion pathway protein
A9D66_03850	COG3250	beta-galactosidase activity
A9D66_03875	COG1609	Transcriptional regulator
A9D66_03880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A9D66_03885	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A9D66_03895	COG0617	tRNA 3'-terminal CCA addition
A9D66_03900	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A9D66_03905	COG1012	belongs to the aldehyde dehydrogenase family
A9D66_03910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A9D66_03925	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A9D66_03940	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A9D66_03945	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A9D66_03960	COG2205	protein histidine kinase activity
A9D66_03965	COG0745	RESPONSE REGULATOR receiver
A9D66_03990	COG3791	Glutathione-dependent formaldehyde-activating
A9D66_04005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A9D66_04025	COG0488	(ABC) transporter
A9D66_04035	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A9D66_04040	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A9D66_04050	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A9D66_04050	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A9D66_04070	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A9D66_04075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A9D66_04080	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A9D66_04100	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A9D66_04105	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A9D66_04110	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A9D66_04115	COG2205	protein histidine kinase activity
A9D66_04120	COG0745	RESPONSE REGULATOR receiver
A9D66_04135	COG0277	FAD linked oxidase domain protein
A9D66_04140	COG1988	membrane-bound metal-dependent
A9D66_04145	COG0792	nuclease activity
A9D66_04175	COG2001	Belongs to the MraZ family
A9D66_04180	COG0275	rRNA processing
A9D66_04185	COG3116	cell division
A9D66_04195	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A9D66_04200	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A9D66_04205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A9D66_04215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A9D66_04220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A9D66_04225	COG1181	Belongs to the D-alanine--D-alanine ligase family
A9D66_04230	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A9D66_04245	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A9D66_04255	COG0739	heme binding
A9D66_04260	COG0653	protein targeting
A9D66_04265	COG0494	nUDIX hydrolase
A9D66_04275	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A9D66_04285	COG0604	alcohol dehydrogenase
A9D66_04285	COG1028	Short-chain dehydrogenase reductase Sdr
A9D66_04285	COG3321	synthase
A9D66_04305	COG0366	Alpha amylase catalytic
A9D66_04335	COG2226	methyltransferase
A9D66_04340	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A9D66_04350	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A9D66_04385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A9D66_04395	COG4106	trans-aconitate 2-methyltransferase activity
A9D66_04400	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A9D66_04410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A9D66_04415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A9D66_04420	COG0667	Aldo Keto reductase
A9D66_04430	COG4771	TonB-dependent receptor
A9D66_04450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A9D66_04455	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A9D66_04465	COG2175	clavaminate synthase activity
A9D66_04475	COG4181	ATPase activity
A9D66_04490	COG0642	Histidine kinase
A9D66_04505	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A9D66_04525	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A9D66_04530	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A9D66_04545	COG3829	transcription factor binding
A9D66_04555	COG1116	anion transmembrane transporter activity
A9D66_04560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A9D66_04570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A9D66_04575	COG0431	NADPH-dependent FMN reductase
A9D66_04605	COG0747	negative chemotaxis
A9D66_04625	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A9D66_04630	COG2967	ApaG domain
A9D66_04635	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A9D66_04640	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A9D66_04645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A9D66_04650	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A9D66_04655	COG0123	including yeast histone deacetylase and acetoin utilization protein
A9D66_04660	COG2096	Adenosyltransferase
A9D66_04675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A9D66_04680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A9D66_04710	COG3384	dioxygenase
A9D66_04715	COG0583	DNA-binding transcription factor activity
A9D66_04730	COG1024	Enoyl-CoA hydratase
A9D66_04750	COG3386	PFAM SMP-30 Gluconolaconase
A9D66_04765	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A9D66_04795	COG0697	spore germination
A9D66_04805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A9D66_04820	COG0745	RESPONSE REGULATOR receiver
A9D66_04820	COG3706	GGDEF domain
A9D66_04830	COG2197	response regulator
A9D66_04840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A9D66_04850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A9D66_04855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A9D66_04860	COG0583	DNA-binding transcription factor activity
A9D66_04865	COG3634	alkyl hydroperoxide reductase activity
A9D66_04875	COG2890	protein-(glutamine-N5) methyltransferase activity
A9D66_04895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A9D66_04895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A9D66_04930	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A9D66_04950	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A9D66_04955	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A9D66_04970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A9D66_04975	COG1404	Belongs to the peptidase S8 family
A9D66_04980	COG1404	Belongs to the peptidase S8 family
A9D66_04985	COG1404	Belongs to the peptidase S8 family
A9D66_04990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A9D66_05015	COG1295	ribonuclease BN
A9D66_05020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A9D66_05025	COG1254	Belongs to the acylphosphatase family
A9D66_05040	COG0521	Mo-molybdopterin cofactor biosynthetic process
A9D66_05050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A9D66_05055	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A9D66_05065	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A9D66_05070	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A9D66_05080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A9D66_05085	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A9D66_05090	COG0193	aminoacyl-tRNA hydrolase activity
A9D66_05095	COG0012	GTP binding
A9D66_05115	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A9D66_05125	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A9D66_05130	COG0250	Participates in transcription elongation, termination and antitermination
A9D66_05135	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A9D66_05140	COG0081	regulation of translation
A9D66_05145	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A9D66_05150	COG0222	ribosome binding
A9D66_05155	COG0085	RNA polymerase activity
A9D66_05160	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A9D66_05165	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A9D66_05170	COG0049	tRNA binding
A9D66_05175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A9D66_05180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A9D66_05185	COG0051	transcription antitermination factor activity, RNA binding
A9D66_05190	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A9D66_05195	COG0088	Forms part of the polypeptide exit tunnel
A9D66_05200	COG0089	rRNA binding
A9D66_05205	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A9D66_05210	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A9D66_05215	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A9D66_05220	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A9D66_05225	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A9D66_05230	COG0255	Belongs to the universal ribosomal protein uL29 family
A9D66_05235	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A9D66_05240	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A9D66_05245	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A9D66_05250	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A9D66_05255	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A9D66_05260	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A9D66_05265	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A9D66_05270	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A9D66_05275	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A9D66_05280	COG1841	ribosomal large subunit assembly
A9D66_05285	COG0200	Binds to the 23S rRNA
A9D66_05290	COG0201	protein transport
A9D66_05295	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A9D66_05300	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A9D66_05305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A9D66_05310	COG0202	RNA polymerase activity
A9D66_05315	COG0203	ribosomal protein L17
A9D66_05320	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A9D66_05335	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A9D66_05345	COG0154	amidase activity
A9D66_05360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A9D66_05365	COG0039	L-malate dehydrogenase activity
A9D66_05370	COG0625	glutathione transferase activity
A9D66_05380	COG1902	pentaerythritol trinitrate reductase activity
A9D66_05380	COG0446	pyridine nucleotide-disulphide oxidoreductase
A9D66_05385	COG0604	alcohol dehydrogenase
A9D66_05415	COG0156	8-amino-7-oxononanoate synthase activity
A9D66_05420	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A9D66_05425	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A9D66_05430	COG4208	sulfate ABC transporter
A9D66_05435	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A9D66_05445	COG1063	alcohol dehydrogenase
A9D66_05475	COG0406	alpha-ribazole phosphatase activity
A9D66_05480	COG0285	dihydrofolate synthase activity
A9D66_05500	COG2833	Protein of unknown function (DUF455)
A9D66_05520	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A9D66_05525	COG0671	phosphoesterase, PA-phosphatase related
A9D66_05530	COG0438	transferase activity, transferring glycosyl groups
A9D66_05540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A9D66_05555	COG4783	chaperone-mediated protein folding
A9D66_05570	COG0473	3-isopropylmalate dehydrogenase activity
A9D66_05805	COG4695	Portal protein
A9D66_05845	COG3852	Histidine kinase
A9D66_05855	COG0544	peptidyl-prolyl cis-trans isomerase activity
A9D66_05860	COG0740	serine-type endopeptidase activity
A9D66_05865	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A9D66_05895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A9D66_05905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A9D66_05915	COG0328	RNA-DNA hybrid ribonuclease activity
A9D66_05920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A9D66_05925	COG0631	protein serine/threonine phosphatase activity
A9D66_05940	COG0859	PFAM glycosyl transferase family 9
A9D66_05945	COG3642	lipopolysaccharide core region biosynthetic process
A9D66_05950	COG1234	tRNA 3'-trailer cleavage
A9D66_05955	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A9D66_05970	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A9D66_05975	COG0314	molybdopterin synthase activity
A9D66_05995	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A9D66_06000	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A9D66_06005	COG0537	adenosine 5'-monophosphoramidase activity
A9D66_06025	COG0714	Associated with various cellular activities
A9D66_06045	COG0424	maF-like protein
A9D66_06050	COG1399	metal-binding, possibly nucleic acid-binding protein
A9D66_06055	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A9D66_06060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A9D66_06075	COG1028	Short-chain dehydrogenase reductase Sdr
A9D66_06080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A9D66_06090	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A9D66_06095	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A9D66_06140	COG3829	transcription factor binding
A9D66_06160	COG3609	addiction module antidote protein, CC2985 family
A9D66_06185	COG2373	Large extracellular alpha-helical protein
A9D66_06200	COG4953	penicillin-binding protein 1C
A9D66_06210	COG0678	peroxiredoxin activity
A9D66_06230	COG0330	HflC and HflK could
A9D66_06235	COG0330	HflC and HflK could
A9D66_06245	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A9D66_06250	COG0308	aminopeptidase N
A9D66_06260	COG1028	Short-chain dehydrogenase reductase Sdr
A9D66_06265	COG1309	transcriptional regulator
A9D66_06290	COG0732	type I restriction modification DNA specificity domain
A9D66_06315	COG0328	RNA-DNA hybrid ribonuclease activity
A9D66_06315	COG0406	alpha-ribazole phosphatase activity
A9D66_06320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A9D66_06330	COG3387	PFAM Glycoside hydrolase 15-related
A9D66_06335	COG1028	Short-chain dehydrogenase reductase Sdr
A9D66_06345	COG3537	Alpha-1,2-mannosidase
A9D66_06350	COG1028	Short-chain dehydrogenase reductase Sdr
A9D66_06365	COG0492	ferredoxin-NADP+ reductase activity
A9D66_06390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A9D66_06395	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A9D66_06400	COG2080	2 iron, 2 sulfur cluster binding
A9D66_06435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A9D66_06450	COG0587	DNA-directed DNA polymerase activity
A9D66_06465	COG1297	OPT oligopeptide transporter protein
A9D66_06485	COG0823	Involved in the tonB-independent uptake of proteins
A9D66_06485	COG1506	peptidase
A9D66_06505	COG1917	Cupin 2, conserved barrel domain protein
A9D66_06505	COG2207	Transcriptional regulator
A9D66_06520	COG0753	catalase activity
A9D66_06525	COG0656	L-ascorbic acid biosynthetic process
A9D66_06535	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A9D66_06535	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A9D66_06540	COG2814	Major facilitator Superfamily
A9D66_06555	COG2194	sulfuric ester hydrolase activity
A9D66_06570	COG0745	RESPONSE REGULATOR receiver
A9D66_06575	COG0642	Histidine kinase
A9D66_06585	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A9D66_06590	COG2894	cell division
A9D66_06595	COG0850	regulation of cytokinetic process
A9D66_06610	COG4585	Histidine kinase
A9D66_06615	COG2197	response regulator
A9D66_06630	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A9D66_06655	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A9D66_06665	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A9D66_06685	COG1946	Acyl-CoA thioesterase
A9D66_06700	COG0824	Thioesterase
A9D66_06705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A9D66_06710	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A9D66_06715	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A9D66_06720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A9D66_06725	COG0268	Binds directly to 16S ribosomal RNA
A9D66_06735	COG0196	riboflavin kinase activity
A9D66_06740	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A9D66_06745	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A9D66_06750	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A9D66_06765	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A9D66_06770	COG1845	cytochrome c oxidase, subunit III
A9D66_06775	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A9D66_06790	COG3152	Membrane
A9D66_06800	COG2207	Transcriptional regulator
A9D66_06805	COG0326	Molecular chaperone. Has ATPase activity
A9D66_06820	COG1366	Belongs to the anti-sigma-factor antagonist family
A9D66_06825	COG1366	Belongs to the anti-sigma-factor antagonist family
A9D66_06830	COG2172	sigma factor antagonist activity
A9D66_06855	COG4771	TonB-dependent receptor
A9D66_06865	COG5507	3-demethylubiquinone-9 3-methyltransferase
A9D66_06870	COG2205	protein histidine kinase activity
A9D66_06880	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A9D66_06885	COG4999	Histidine kinase
A9D66_06885	COG2205	protein histidine kinase activity
A9D66_06885	COG3850	Histidine kinase
A9D66_06885	COG3437	response regulator, receiver
A9D66_06890	COG4191	Histidine kinase
A9D66_06890	COG0784	Response regulator, receiver
A9D66_06920	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A9D66_06925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A9D66_06940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A9D66_06945	COG0228	four-way junction DNA binding
A9D66_06950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A9D66_06955	COG0336	Belongs to the RNA methyltransferase TrmD family
A9D66_06960	COG0335	large ribosomal subunit rRNA binding
A9D66_06965	COG0534	Mate efflux family protein
A9D66_06990	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A9D66_07000	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A9D66_07020	COG2963	transposase activity
A9D66_07025	COG2801	Transposase and inactivated derivatives
A9D66_07045	COG3250	beta-galactosidase activity
A9D66_07050	COG3867	Arabinogalactan endo-beta-1,4-galactanase
A9D66_07070	COG1960	acyl-CoA dehydrogenase activity
A9D66_07075	COG1024	Enoyl-CoA hydratase
A9D66_07095	COG1024	Enoyl-CoA hydratase
A9D66_07095	COG1250	3-hydroxyacyl-CoA dehydrogenase
A9D66_07110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A9D66_07115	COG0481	GTPase activity
A9D66_07130	COG0571	ribonuclease III activity
A9D66_07135	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A9D66_07140	COG1381	Involved in DNA repair and RecF pathway recombination
A9D66_07150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A9D66_07160	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A9D66_07165	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
A9D66_07170	COG3046	protein related to deoxyribodipyrimidine photolyase
A9D66_07175	COG1472	Belongs to the glycosyl hydrolase 3 family
A9D66_07185	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A9D66_07190	COG1278	Cold shock
A9D66_07210	COG1201	RNA secondary structure unwinding
A9D66_07215	COG1793	dna ligase
A9D66_07225	COG1793	dna ligase
A9D66_07225	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A9D66_07240	COG0745	RESPONSE REGULATOR receiver
A9D66_07240	COG3706	GGDEF domain
A9D66_07255	COG0183	Belongs to the thiolase family
A9D66_07280	COG1451	nucleotide metabolic process
A9D66_07285	COG5487	UPF0391 membrane protein
A9D66_07295	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A9D66_07315	COG1077	Cell shape determining protein MreB Mrl
A9D66_07320	COG1047	Peptidyl-prolyl cis-trans
A9D66_07330	COG2824	Alkylphosphonate utilization operon protein PhnA
A9D66_07335	COG1902	pentaerythritol trinitrate reductase activity
A9D66_07340	COG2814	Major facilitator Superfamily
A9D66_07375	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A9D66_07375	COG0392	lysyltransferase activity
A9D66_07385	COG0251	oxidation-reduction process
A9D66_07390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A9D66_07405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A9D66_07430	COG1595	DNA-templated transcription, initiation
A9D66_07450	COG2878	Part of a membrane complex involved in electron transport
A9D66_07460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A9D66_07460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A9D66_07475	COG1131	(ABC) transporter
A9D66_07480	COG0346	lactoylglutathione lyase activity
A9D66_07485	COG0833	amino acid
A9D66_07490	COG2040	homocysteine
A9D66_07500	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A9D66_07520	COG1695	Transcriptional regulator
A9D66_07555	COG0825	malonyl-CoA metabolic process
A9D66_07565	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A9D66_07570	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A9D66_07575	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A9D66_07580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A9D66_07585	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A9D66_07600	COG0750	zinc metalloprotease
A9D66_07605	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A9D66_07610	COG0575	Belongs to the CDS family
A9D66_07615	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A9D66_07620	COG0233	cytoplasmic translational termination
A9D66_07625	COG0528	UMP kinase activity
A9D66_07630	COG3706	GGDEF domain
A9D66_07630	COG0745	RESPONSE REGULATOR receiver
A9D66_07635	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A9D66_07640	COG0052	Belongs to the universal ribosomal protein uS2 family
A9D66_07675	COG0024	Methionine aminopeptidase
A9D66_07680	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A9D66_07690	COG1393	Belongs to the ArsC family
A9D66_07695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A9D66_07700	COG0367	asparagine synthase
A9D66_07710	COG4774	siderophore transport
A9D66_07725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A9D66_07750	COG1566	PFAM secretion protein HlyD family protein
A9D66_07755	COG2814	Major facilitator Superfamily
A9D66_07775	COG3104	oligopeptide transport
A9D66_07805	COG0339	signal peptide processing
A9D66_07810	COG0386	Belongs to the glutathione peroxidase family
A9D66_07865	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A9D66_07870	COG0084	hydrolase, TatD family'
A9D66_07885	COG1960	acyl-CoA dehydrogenase activity
A9D66_07905	COG0367	asparagine synthase
A9D66_07915	COG0305	Participates in initiation and elongation during chromosome replication
A9D66_07920	COG0415	Belongs to the DNA photolyase family
A9D66_07930	COG0583	DNA-binding transcription factor activity
A9D66_07965	COG3706	GGDEF domain
A9D66_07975	COG3706	GGDEF domain
A9D66_08210	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A9D66_08225	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A9D66_08235	COG0497	DNA recombination
A9D66_08240	COG1420	regulation of RNA biosynthetic process
A9D66_08245	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A9D66_08250	COG0443	Heat shock 70 kDa protein
A9D66_08255	COG0484	heat shock protein binding
A9D66_08260	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A9D66_08290	COG0583	DNA-binding transcription factor activity
A9D66_08295	COG1132	(ABC) transporter
A9D66_08330	COG2850	peptidyl-arginine hydroxylation
A9D66_08350	COG1253	flavin adenine dinucleotide binding
A9D66_08380	COG1131	(ABC) transporter
A9D66_08385	COG1725	Transcriptional regulator
A9D66_08390	COG0386	Belongs to the glutathione peroxidase family
A9D66_08405	COG2900	Belongs to the SlyX family
A9D66_08430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A9D66_08440	COG0646	methionine synthase
A9D66_08440	COG1410	methionine synthase
A9D66_08445	COG0646	methionine synthase
A9D66_08445	COG1410	methionine synthase
A9D66_08455	COG1960	acyl-CoA dehydrogenase activity
A9D66_08470	COG0557	exoribonuclease II activity
A9D66_08480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A9D66_08485	COG3706	GGDEF domain
A9D66_08490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A9D66_08500	COG0704	Plays a role in the regulation of phosphate uptake
A9D66_08505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A9D66_08510	COG0581	inorganic phosphate transmembrane transporter activity
A9D66_08515	COG0573	inorganic phosphate transmembrane transporter activity
A9D66_08520	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A9D66_08545	COG0659	secondary active sulfate transmembrane transporter activity
A9D66_08550	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A9D66_08560	COG1024	Enoyl-CoA hydratase
A9D66_08570	COG0494	nUDIX hydrolase
A9D66_08615	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A9D66_08640	COG2925	Exonuclease
A9D66_08650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A9D66_08655	COG3844	kynureninase activity
A9D66_08665	COG0662	Cupin 2, conserved barrel domain protein
A9D66_08670	COG0288	reversible hydration of carbon dioxide
A9D66_08735	COG2808	Putative FMN-binding domain
A9D66_08755	COG0017	Asparaginyl-tRNA synthetase
A9D66_08760	COG0316	Belongs to the HesB IscA family
A9D66_08765	COG0360	Binds together with S18 to 16S ribosomal RNA
A9D66_08770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A9D66_08775	COG0359	binds to the 23S rRNA
A9D66_08785	COG3115	cell septum assembly
A9D66_08795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A9D66_08800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A9D66_08805	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A9D66_08815	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A9D66_08825	COG4993	Dehydrogenase
A9D66_08835	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A9D66_08845	COG2986	histidine ammonia-lyase
A9D66_08850	COG1228	amidohydrolase
A9D66_08895	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A9D66_08900	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A9D66_08905	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A9D66_08910	COG0077	Prephenate dehydratase
A9D66_08910	COG1605	Chorismate mutase
A9D66_08915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A9D66_08930	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A9D66_08935	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A9D66_08940	COG0583	DNA-binding transcription factor activity
A9D66_08955	COG0840	transmembrane signaling receptor activity
A9D66_08985	COG0784	Response regulator, receiver
A9D66_08985	COG2205	protein histidine kinase activity
A9D66_08985	COG5002	protein histidine kinase activity
A9D66_08995	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A9D66_09000	COG4191	Histidine kinase
A9D66_09000	COG0784	Response regulator, receiver
A9D66_09015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A9D66_09025	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A9D66_09035	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A9D66_09050	COG1595	DNA-templated transcription, initiation
A9D66_09105	COG2244	polysaccharide biosynthetic process
A9D66_09135	COG2264	protein methyltransferase activity
A9D66_09160	COG1136	(ABC) transporter
A9D66_09170	COG0477	Major facilitator Superfamily
A9D66_09175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A9D66_09190	COG1253	flavin adenine dinucleotide binding
A9D66_09200	COG0306	phosphate transporter
A9D66_09225	COG0504	CTP synthase activity
A9D66_09230	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A9D66_09240	COG0148	phosphopyruvate hydratase activity
A9D66_09245	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A9D66_09250	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A9D66_09255	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A9D66_09260	COG0585	pseudouridine synthase activity
A9D66_09265	COG2840	Smr protein MutS2
A9D66_09270	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A9D66_09275	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A9D66_09280	COG1238	metal cluster binding
A9D66_09295	COG1534	Rna-binding protein
A9D66_09300	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A9D66_09305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A9D66_09310	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A9D66_09315	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A9D66_09320	COG1923	regulation of RNA biosynthetic process
A9D66_09325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A9D66_09330	COG1546	Belongs to the CinA family
A9D66_09340	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A9D66_09345	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A9D66_09350	COG2137	regulation of response to DNA damage stimulus
A9D66_09355	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A9D66_09360	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A9D66_09375	COG1741	Belongs to the pirin family
A9D66_09385	COG0583	DNA-binding transcription factor activity
A9D66_09415	COG0351	phosphomethylpyrimidine kinase
A9D66_09430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A9D66_09435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A9D66_09450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A9D66_09460	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A9D66_09465	COG3734	2-keto-3-deoxy-galactonokinase
A9D66_09475	COG4948	Mandelate Racemase Muconate Lactonizing
A9D66_09480	COG0800	Aldolase
A9D66_09520	COG1501	Belongs to the glycosyl hydrolase 31 family
A9D66_09530	COG1070	Carbohydrate kinase
A9D66_09535	COG2115	Belongs to the xylose isomerase family
A9D66_09540	COG0477	Major facilitator Superfamily
A9D66_09555	COG0860	N-Acetylmuramoyl-L-alanine amidase
A9D66_09560	COG1469	GTP cyclohydrolase I activity
A9D66_09580	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A9D66_09585	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A9D66_09590	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A9D66_09595	COG0166	Belongs to the GPI family
A9D66_09615	COG1472	Belongs to the glycosyl hydrolase 3 family
A9D66_09625	COG2203	Gaf domain
A9D66_09625	COG3706	GGDEF domain
A9D66_09625	COG4251	negative regulation of phosphorylation
A9D66_09625	COG5001	Diguanylate cyclase
A9D66_09630	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A9D66_09635	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A9D66_09645	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A9D66_09650	COG0671	phosphoesterase, PA-phosphatase related
A9D66_09665	COG1794	racemase activity, acting on amino acids and derivatives
A9D66_09670	COG0697	spore germination
A9D66_09675	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A9D66_09680	COG0167	dihydroorotate dehydrogenase activity
A9D66_09700	COG1012	belongs to the aldehyde dehydrogenase family
A9D66_09810	COG2963	transposase activity
A9D66_09815	COG2801	Transposase and inactivated derivatives
A9D66_09825	COG0758	DNA mediated transformation
A9D66_09900	COG2814	Major facilitator Superfamily
A9D66_09955	COG2963	transposase activity
A9D66_09960	COG2801	Transposase and inactivated derivatives
A9D66_10025	COG1215	transferase activity, transferring glycosyl groups
A9D66_10030	COG0726	polysaccharide deacetylase
A9D66_10030	COG1649	PFAM Uncharacterised BCR, COG1649
A9D66_10085	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A9D66_10115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A9D66_10120	COG0124	histidyl-tRNA synthetase
A9D66_10130	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A9D66_10135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A9D66_10140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A9D66_10145	COG0131	Imidazoleglycerol-phosphate dehydratase
A9D66_10145	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A9D66_10150	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A9D66_10155	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A9D66_10160	COG0107	imidazoleglycerol-phosphate synthase activity
A9D66_10165	COG0140	phosphoribosyl-ATP diphosphatase activity
A9D66_10165	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A9D66_10180	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
A9D66_10185	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A9D66_10190	COG0235	Class ii aldolase
A9D66_10195	COG0531	amino acid
A9D66_10200	COG0531	amino acid
A9D66_10210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A9D66_10215	COG0277	FAD linked oxidase domain protein
A9D66_10235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A9D66_10280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A9D66_10285	COG2258	MOSC domain
A9D66_10290	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A9D66_10295	COG0505	Belongs to the CarA family
A9D66_10305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A9D66_10310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A9D66_10320	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A9D66_10330	COG3279	Response regulator of the LytR AlgR family
A9D66_10335	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A9D66_10340	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A9D66_10355	COG2205	protein histidine kinase activity
A9D66_10355	COG0784	Response regulator, receiver
A9D66_10355	COG2198	Histidine kinase
A9D66_10360	COG1024	Enoyl-CoA hydratase
A9D66_10365	COG0318	PFAM AMP-dependent synthetase and ligase
A9D66_10395	COG2267	carboxylic ester hydrolase activity
A9D66_10405	COG2201	protein-glutamate methylesterase activity
A9D66_10410	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A9D66_10420	COG0840	transmembrane signaling receptor activity
A9D66_10430	COG0835	chemotaxis
A9D66_10440	COG0840	transmembrane signaling receptor activity
A9D66_10445	COG0840	transmembrane signaling receptor activity
A9D66_10450	COG0840	transmembrane signaling receptor activity
A9D66_10455	COG0840	transmembrane signaling receptor activity
A9D66_10460	COG0840	transmembrane signaling receptor activity
A9D66_10470	COG0840	transmembrane signaling receptor activity
A9D66_10475	COG0840	transmembrane signaling receptor activity
A9D66_10480	COG0840	transmembrane signaling receptor activity
A9D66_10485	COG0840	transmembrane signaling receptor activity
A9D66_10495	COG0840	transmembrane signaling receptor activity
A9D66_10500	COG0840	transmembrane signaling receptor activity
A9D66_10510	COG0840	transmembrane signaling receptor activity
A9D66_10515	COG2198	Histidine kinase
A9D66_10515	COG0643	Histidine kinase
A9D66_10520	COG0745	RESPONSE REGULATOR receiver
A9D66_10530	COG0835	chemotaxis
A9D66_10535	COG1192	Involved in chromosome partitioning
A9D66_10540	COG1360	Flagellar Motor Protein
A9D66_10545	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A9D66_10585	COG2801	Transposase and inactivated derivatives
A9D66_10590	COG2963	transposase activity
A9D66_10610	COG0641	radical SAM
A9D66_10620	COG0643	Histidine kinase
A9D66_10620	COG2198	Histidine kinase
A9D66_10640	COG0455	bacterial-type flagellum organization
A9D66_10650	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A9D66_10665	COG3300	MHYT domain
A9D66_10665	COG5001	Diguanylate cyclase
A9D66_10675	COG5001	Diguanylate cyclase
A9D66_10675	COG3300	MHYT domain
A9D66_10680	COG1684	flagellar biosynthetic protein fliR
A9D66_10685	COG1987	bacterial-type flagellum assembly
A9D66_10695	COG3190	flagellar
A9D66_10745	COG1677	Flagellar hook-basal body complex protein FliE
A9D66_10780	COG1028	Short-chain dehydrogenase reductase Sdr
A9D66_10785	COG1028	Short-chain dehydrogenase reductase Sdr
A9D66_10790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A9D66_10805	COG2204	response regulator
A9D66_10810	COG2201	protein-glutamate methylesterase activity
A9D66_10840	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A9D66_10845	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A9D66_10850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A9D66_10860	COG3951	Flagellar rod assembly protein muramidase FlgJ
A9D66_10860	COG1705	Flagellar rod assembly protein muramidase FlgJ
A9D66_10865	COG1706	bacterial-type flagellum-dependent cell motility
A9D66_10870	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A9D66_10875	COG4786	Flagellar basal body rod
A9D66_10880	COG4787	bacterial-type flagellum-dependent cell motility
A9D66_10885	COG1749	Flagellar hook protein flgE
A9D66_10890	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A9D66_10895	COG1558	bacterial-type flagellum-dependent cell motility
A9D66_10905	COG0835	chemotaxis
A9D66_10905	COG0784	Response regulator, receiver
A9D66_10925	COG5002	protein histidine kinase activity
A9D66_10955	COG2915	High frequency lysogenization protein hflD homolog
A9D66_10960	COG0482	sulfurtransferase activity
A9D66_10970	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A9D66_10975	COG0542	response to heat
A9D66_10980	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A9D66_10985	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A9D66_10995	COG0492	ferredoxin-NADP+ reductase activity
A9D66_11000	COG1674	ftsk spoiiie
A9D66_11010	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A9D66_11020	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A9D66_11025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A9D66_11030	COG0183	Belongs to the thiolase family
A9D66_11035	COG1250	3-hydroxyacyl-CoA dehydrogenase
A9D66_11035	COG1024	Enoyl-CoA hydratase
A9D66_11045	COG0105	UTP biosynthetic process
A9D66_11050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A9D66_11060	COG1426	Protein conserved in bacteria
A9D66_11070	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A9D66_11075	COG1160	GTP binding
A9D66_11080	COG0303	'Molybdopterin
A9D66_11085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A9D66_11120	COG0708	Exodeoxyribonuclease III
A9D66_11130	COG0303	'Molybdopterin
A9D66_11135	COG0746	molybdenum cofactor guanylyltransferase activity
A9D66_11145	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A9D66_11145	COG1648	precorrin-2 dehydrogenase activity
A9D66_11180	COG5001	Diguanylate cyclase
A9D66_11190	COG4566	intracellular signal transduction
A9D66_11230	COG3275	phosphorelay sensor kinase activity
A9D66_11235	COG3279	Response regulator of the LytR AlgR family
A9D66_11270	COG1238	metal cluster binding
A9D66_11275	COG0577	efflux transmembrane transporter activity
A9D66_11275	COG1136	(ABC) transporter
A9D66_11320	COG1028	Short-chain dehydrogenase reductase Sdr
A9D66_11325	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A9D66_11330	COG1073	alpha beta
A9D66_11330	COG2226	methyltransferase
A9D66_11380	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A9D66_11380	COG0316	Belongs to the HesB IscA family
A9D66_11385	COG2154	pterin-4-alpha-carbinolamine dehydratase
A9D66_11395	COG0428	transporter
A9D66_11400	COG3064	Membrane
A9D66_11410	COG1530	ribonuclease E activity
A9D66_11440	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A9D66_11470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A9D66_11475	COG1061	Type III restriction enzyme res subunit
A9D66_11480	COG1002	Type II restriction enzyme, methylase subunits
A9D66_11505	COG1192	Involved in chromosome partitioning
A9D66_11540	COG0629	single-stranded DNA binding
A9D66_11550	COG0270	DNA (cytosine-5-)-methyltransferase activity
A9D66_11595	COG2826	transposase and inactivated derivatives, IS30 family
A9D66_11720	COG2003	Belongs to the UPF0758 family
A9D66_11800	COG2963	transposase activity
A9D66_11805	COG2801	Transposase and inactivated derivatives
A9D66_11815	COG0583	DNA-binding transcription factor activity
A9D66_11820	COG1396	sequence-specific DNA binding
A9D66_11825	COG0582	viral genome integration into host DNA
A9D66_11845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A9D66_11850	COG0322	excinuclease ABC activity
A9D66_11860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A9D66_11865	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A9D66_11870	COG1663	tetraacyldisaccharide 4'-kinase activity
A9D66_11875	COG1132	(ABC) transporter
A9D66_11885	COG0811	peptide transport
A9D66_11900	COG1136	(ABC) transporter
A9D66_11905	COG4591	ABC-type transport system involved in lipoprotein release permease component
A9D66_11915	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A9D66_11920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A9D66_11935	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A9D66_11955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A9D66_11960	COG0837	glucose binding
A9D66_11965	COG0363	glucosamine-6-phosphate deaminase activity
A9D66_11970	COG0129	dihydroxy-acid dehydratase activity
A9D66_11975	COG0800	Aldolase
A9D66_12085	COG1196	nuclear chromosome segregation
A9D66_12240	COG0305	Participates in initiation and elongation during chromosome replication
A9D66_12265	COG4197	protein conserved in bacteria, prophage-related
A9D66_12385	COG2205	protein histidine kinase activity
A9D66_12385	COG0784	Response regulator, receiver
A9D66_12390	COG2183	response to ionizing radiation
A9D66_12400	COG0723	plastoquinol--plastocyanin reductase activity
A9D66_12400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A9D66_12415	COG3243	poly(R)-hydroxyalkanoic acid synthase
A9D66_12425	COG1183	phosphatidylcholine synthase activity
A9D66_12430	COG1028	Short-chain dehydrogenase reductase Sdr
A9D66_12445	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A9D66_12455	COG0668	transmembrane transport
A9D66_12460	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A9D66_12465	COG0590	tRNA wobble adenosine to inosine editing
A9D66_12470	COG1321	iron dependent repressor
A9D66_12475	COG1914	H( )-stimulated, divalent metal cation uptake system
A9D66_12495	COG2814	Major facilitator Superfamily
A9D66_12525	COG2197	response regulator
A9D66_12550	COG0583	DNA-binding transcription factor activity
A9D66_12555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A9D66_12560	COG3002	Belongs to the UPF0753 family
A9D66_12565	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A9D66_12655	COG0582	viral genome integration into host DNA
A9D66_12660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A9D66_12660	COG0519	Catalyzes the synthesis of GMP from XMP
A9D66_12670	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A9D66_12680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A9D66_12680	COG0475	glutathione-regulated potassium exporter activity
A9D66_12685	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A9D66_12695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A9D66_12700	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A9D66_12710	COG0776	regulation of translation
A9D66_12715	COG0539	negative regulation of cytoplasmic translation
A9D66_12720	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A9D66_12725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A9D66_12735	COG2957	Belongs to the agmatine deiminase family
A9D66_12740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A9D66_12765	COG0395	ABC-type sugar transport system, permease component
A9D66_12770	COG1175	transmembrane transport
A9D66_12800	COG2350	Protein conserved in bacteria
A9D66_12805	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A9D66_12810	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A9D66_12815	COG1187	pseudouridine synthase activity
A9D66_12835	COG0436	Aminotransferase
A9D66_12840	COG4133	protoheme IX ABC transporter activity
A9D66_12860	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A9D66_12865	COG1138	Cytochrome C-type biogenesis protein
A9D66_12885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A9D66_12890	COG1278	Cold shock
A9D66_12895	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A9D66_12900	COG4988	ABC transporter
A9D66_12910	COG1294	oxidase, subunit
A9D66_12940	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A9D66_12945	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A9D66_12955	COG0165	Argininosuccinate lyase
A9D66_12960	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A9D66_12970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A9D66_12985	COG0137	argininosuccinate synthase activity
A9D66_12990	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A9D66_13000	COG0215	cysteine-tRNA ligase activity
A9D66_13005	COG2166	iron-sulfur cluster assembly
A9D66_13015	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A9D66_13020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A9D66_13025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A9D66_13050	COG4302	ethanolamine ammonia-lyase activity
A9D66_13080	COG2963	transposase activity
A9D66_13100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A9D66_13105	COG0402	S-adenosylhomocysteine deaminase activity
A9D66_13115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A9D66_13120	COG1509	lysine 2,3-aminomutase activity
A9D66_13125	COG3300	MHYT domain
A9D66_13125	COG5001	Diguanylate cyclase
A9D66_13140	COG0483	inositol monophosphate 1-phosphatase activity
A9D66_13165	COG0513	Belongs to the DEAD box helicase family
A9D66_13170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A9D66_13175	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A9D66_13185	COG0625	glutathione transferase activity
A9D66_13195	COG4681	YaeQ
A9D66_13200	COG2081	HI0933 family
A9D66_13210	COG0501	Belongs to the peptidase M48B family
A9D66_13215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A9D66_13220	COG1028	Short-chain dehydrogenase reductase Sdr
A9D66_13245	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A9D66_13250	COG0860	N-Acetylmuramoyl-L-alanine amidase
A9D66_13255	COG0802	atpase or kinase
A9D66_13260	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A9D66_13260	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A9D66_13265	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A9D66_13270	COG1570	exodeoxyribonuclease VII activity
A9D66_13280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A9D66_13325	COG0835	chemotaxis
A9D66_13330	COG0840	transmembrane signaling receptor activity
A9D66_13335	COG2094	Belongs to the DNA glycosylase MPG family
A9D66_13340	COG1201	RNA secondary structure unwinding
A9D66_13360	COG2969	positive regulation of protein catabolic process
A9D66_13365	COG0625	glutathione transferase activity
A9D66_13370	COG2857	Cytochrome c1
A9D66_13375	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A9D66_13380	COG0723	plastoquinol--plastocyanin reductase activity
A9D66_13385	COG0741	lytic transglycosylase activity
A9D66_13400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A9D66_13405	COG1702	phosphate starvation-inducible protein PhoH
A9D66_13415	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A9D66_13425	COG4535	Mg2 and Co2 transporter CorC
A9D66_13440	COG1012	belongs to the aldehyde dehydrogenase family
A9D66_13450	COG1177	transmembrane transport
A9D66_13455	COG1176	ABC-type spermidine putrescine transport system, permease component I
A9D66_13480	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A9D66_13500	COG0174	glutamine synthetase
A9D66_13505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A9D66_13510	COG0745	RESPONSE REGULATOR receiver
A9D66_13510	COG3706	GGDEF domain
A9D66_13515	COG2703	oxygen carrier activity
A9D66_13520	COG0477	Major facilitator Superfamily
A9D66_13530	COG0243	molybdopterin cofactor binding
A9D66_13535	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A9D66_13555	COG2733	membrane
A9D66_13560	COG2205	protein histidine kinase activity
A9D66_13560	COG0784	Response regulator, receiver
A9D66_13560	COG5002	protein histidine kinase activity
A9D66_13570	COG0477	Major facilitator Superfamily
A9D66_13575	COG2902	Dehydrogenase
A9D66_13585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9D66_13590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A9D66_13595	COG1609	Transcriptional regulator
A9D66_13600	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A9D66_13600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A9D66_13605	COG1105	Belongs to the carbohydrate kinase PfkB family
A9D66_13610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A9D66_13610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A9D66_13635	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A9D66_13645	COG1862	Preprotein translocase
A9D66_13650	COG0343	queuine tRNA-ribosyltransferase activity
A9D66_13655	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A9D66_13695	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A9D66_13700	COG3291	Pkd domain containing protein
A9D66_13710	COG0405	Gamma-glutamyltransferase
A9D66_13715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A9D66_13730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A9D66_13735	COG0742	ribosomal rna small subunit methyltransferase
A9D66_13740	COG0326	Molecular chaperone. Has ATPase activity
A9D66_13830	COG0531	amino acid
A9D66_13845	COG0006	proline dipeptidase activity
A9D66_13855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A9D66_13870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A9D66_13875	COG3938	Belongs to the proline racemase family
A9D66_13885	COG0552	protein localization to endoplasmic reticulum
A9D66_13890	COG1194	a g-specific adenine glycosylase
A9D66_13895	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A9D66_13900	COG4191	Histidine kinase
A9D66_13900	COG0784	Response regulator, receiver
A9D66_13915	COG0322	excinuclease ABC activity
A9D66_13930	COG3040	lipid binding
A9D66_13945	COG1960	acyl-CoA dehydrogenase activity
A9D66_13955	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A9D66_13975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A9D66_13980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A9D66_13985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A9D66_14020	COG0438	transferase activity, transferring glycosyl groups
A9D66_14025	COG0438	transferase activity, transferring glycosyl groups
A9D66_14070	COG0776	regulation of translation
A9D66_14075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A9D66_14075	COG0072	phenylalanine-tRNA ligase activity
A9D66_14080	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A9D66_14085	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A9D66_14090	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A9D66_14095	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A9D66_14100	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A9D66_14115	COG2211	Major facilitator Superfamily
A9D66_14125	COG1082	Xylose isomerase domain protein TIM barrel
A9D66_14140	COG0366	Alpha amylase catalytic
A9D66_14230	COG3702	type iv secretory pathway
A9D66_14250	COG2948	multi-organism process
A9D66_14270	COG3505	Type IV secretory pathway VirD4
A9D66_14285	COG0556	nucleotide-excision repair
A9D66_14330	COG1611	Belongs to the LOG family
A9D66_14340	COG2095	MarC family integral membrane protein
A9D66_14350	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A9D66_14355	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A9D66_14385	COG1185	polyribonucleotide nucleotidyltransferase activity
A9D66_14390	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A9D66_14395	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A9D66_14400	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A9D66_14405	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A9D66_14410	COG0195	Participates in both transcription termination and antitermination
A9D66_14415	COG0779	Required for maturation of 30S ribosomal subunits
A9D66_14425	COG1007	ATP synthesis coupled electron transport
A9D66_14440	COG0713	ATP synthesis coupled electron transport
A9D66_14450	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A9D66_14455	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A9D66_14465	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A9D66_14470	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A9D66_14475	COG0649	NAD binding
A9D66_14480	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A9D66_14485	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A9D66_14490	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A9D66_14505	COG0149	triose-phosphate isomerase activity
A9D66_14510	COG0300	oxidoreductase activity
A9D66_14545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A9D66_14550	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A9D66_14555	COG0159	tryptophan synthase activity
A9D66_14565	COG0133	tryptophan synthase activity
A9D66_14575	COG0135	phosphoribosylanthranilate isomerase activity
A9D66_14580	COG0101	tRNA pseudouridine synthase activity
A9D66_14605	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A9D66_14610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A9D66_14615	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A9D66_14620	COG2890	protein-(glutamine-N5) methyltransferase activity
A9D66_14630	COG0688	phosphatidylethanolamine metabolic process
A9D66_14640	COG0433	COG0433 Predicted ATPase
A9D66_14645	COG0494	nUDIX hydrolase
A9D66_14660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A9D66_14665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A9D66_14675	COG2336	PFAM SpoVT AbrB
A9D66_14715	COG0420	3'-5' exonuclease activity
A9D66_14745	COG0717	Belongs to the dCTP deaminase family
A9D66_14750	COG0489	protein tyrosine kinase activity
A9D66_14770	COG3590	peptidase
A9D66_14775	COG3590	peptidase
A9D66_14795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A9D66_14800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A9D66_14805	COG2311	Membrane
A9D66_14810	COG1047	Peptidyl-prolyl cis-trans
A9D66_14815	COG0791	NLP P60 protein
A9D66_14820	COG0791	NLP P60 protein
A9D66_14830	COG4106	trans-aconitate 2-methyltransferase activity
A9D66_14835	COG1301	dicarboxylic acid transport
A9D66_14840	COG1785	Belongs to the alkaline phosphatase family
A9D66_14845	COG0037	tRNA processing
A9D66_14850	COG1722	exodeoxyribonuclease VII activity
A9D66_14855	COG0142	geranyltranstransferase activity
A9D66_14860	COG4104	PAAR repeat-containing protein
A9D66_14870	COG0312	modulator of DNA gyrase
A9D66_14875	COG3028	Belongs to the UPF0307 family
A9D66_14880	COG0312	modulator of DNA gyrase
A9D66_14890	COG3164	Protein of unknown function
A9D66_14895	COG1530	ribonuclease E activity
A9D66_14900	COG0424	maF-like protein
A9D66_14905	COG2968	Membrane
A9D66_14920	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A9D66_14935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A9D66_14950	COG0495	leucyl-tRNA aminoacylation
A9D66_14960	COG3118	belongs to the thioredoxin family
A9D66_14985	COG2155	Conserved Protein
A9D66_14990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A9D66_15030	COG1132	(ABC) transporter
A9D66_15060	COG1538	Outer membrane efflux protein
A9D66_15065	COG0745	RESPONSE REGULATOR receiver
A9D66_15070	COG5000	phosphorelay sensor kinase activity
A9D66_15070	COG5002	protein histidine kinase activity
A9D66_15075	COG0475	glutathione-regulated potassium exporter activity
A9D66_15080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A9D66_15085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A9D66_15110	COG1187	pseudouridine synthase activity
A9D66_15115	COG5002	protein histidine kinase activity
A9D66_15115	COG5001	Diguanylate cyclase
A9D66_15220	COG2951	lytic endotransglycosylase activity
A9D66_15225	COG4644	lycopene metabolic process
A9D66_15240	COG2369	cell adhesion
A9D66_15290	COG0667	Aldo Keto reductase
A9D66_15295	COG2814	Major facilitator Superfamily
A9D66_15300	COG0583	DNA-binding transcription factor activity
A9D66_15310	COG2207	Transcriptional regulator
A9D66_15325	COG0667	Aldo Keto reductase
A9D66_15330	COG1309	transcriptional regulator
A9D66_15335	COG1538	Outer membrane efflux protein
A9D66_15340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A9D66_15355	COG0735	belongs to the Fur family
A9D66_15360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A9D66_15385	COG4452	Inner membrane protein CreD
A9D66_15395	COG2205	protein histidine kinase activity
A9D66_15400	COG0745	RESPONSE REGULATOR receiver
A9D66_15405	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A9D66_15415	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A9D66_15425	COG2198	Histidine kinase
A9D66_15425	COG0643	Histidine kinase
A9D66_15430	COG0840	transmembrane signaling receptor activity
A9D66_15435	COG0835	chemotaxis
A9D66_15440	COG2200	EAL domain
A9D66_15440	COG2199	diguanylate cyclase activity
A9D66_15440	COG2202	Pas domain
A9D66_15445	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A9D66_15450	COG2201	protein-glutamate methylesterase activity
A9D66_15455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A9D66_15460	COG3590	peptidase
A9D66_15470	COG0588	phosphoglycerate mutase activity
A9D66_15475	COG1515	deoxyribonuclease V activity
A9D66_15485	COG1741	Belongs to the pirin family
A9D66_15500	COG1741	Belongs to the pirin family
A9D66_15505	COG1966	Carbon starvation protein
A9D66_15510	COG2879	small protein
A9D66_15555	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A9D66_15560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A9D66_15565	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A9D66_15570	COG2080	2 iron, 2 sulfur cluster binding
A9D66_15580	COG2203	Gaf domain
A9D66_15580	COG5001	Diguanylate cyclase
A9D66_15580	COG3706	GGDEF domain
A9D66_15580	COG4251	negative regulation of phosphorylation
A9D66_15585	COG0629	single-stranded DNA binding
A9D66_15590	COG0142	geranyltranstransferase activity
A9D66_15600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A9D66_15615	COG0527	aspartate kinase activity
A9D66_15620	COG0384	phenazine biosynthesis protein PhzF
A9D66_15625	COG0384	phenazine biosynthesis protein PhzF
A9D66_15635	COG1764	response to oxidative stress
A9D66_15640	COG0540	Belongs to the ATCase OTCase family
A9D66_15645	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A9D66_15650	COG1678	Uncharacterized ACR, COG1678
A9D66_15660	COG0519	Catalyzes the synthesis of GMP from XMP
A9D66_15685	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A9D66_15700	COG0739	heme binding
A9D66_15720	COG0693	protein deglycase activity
A9D66_15730	COG1959	2 iron, 2 sulfur cluster binding
A9D66_15735	COG0719	Fe-S assembly protein
A9D66_15740	COG0396	ATPase activity
A9D66_15745	COG0719	Fe-S assembly protein
A9D66_15750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A9D66_15765	COG4774	siderophore transport
A9D66_15770	COG3128	pkhd-type hydroxylase
A9D66_15795	COG1477	protein flavinylation
A9D66_15800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A9D66_15815	COG1555	photosystem II stabilization
A9D66_15830	COG3178	'Phosphotransferase
A9D66_15835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A9D66_15845	COG0628	permease
A9D66_15855	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A9D66_15865	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A9D66_15885	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A9D66_15890	COG0271	Belongs to the BolA IbaG family
A9D66_15900	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A9D66_15910	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A9D66_15915	COG1137	ATPase activity
A9D66_15930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A9D66_15935	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A9D66_15940	COG1660	Displays ATPase and GTPase activities
A9D66_15950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A9D66_15955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A9D66_15960	COG2239	Acts as a magnesium transporter
A9D66_15975	COG1294	oxidase, subunit
A9D66_15980	COG1271	oxidase subunit
A9D66_15990	COG1113	amino acid transport
A9D66_16010	COG2197	response regulator
A9D66_16015	COG0531	amino acid
A9D66_16075	COG2963	transposase activity
A9D66_16080	COG2801	Transposase and inactivated derivatives
A9D66_16105	COG0754	glutathionylspermidine amidase activity
A9D66_16130	COG1842	Phage shock protein A
A9D66_16140	COG0259	pyridoxamine-phosphate oxidase activity
A9D66_16145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A9D66_16150	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A9D66_16160	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A9D66_16165	COG0477	Major facilitator Superfamily
A9D66_16180	COG0745	RESPONSE REGULATOR receiver
A9D66_16185	COG2205	protein histidine kinase activity
A9D66_16190	COG2205	protein histidine kinase activity
A9D66_16190	COG2198	Histidine kinase
A9D66_16190	COG0784	Response regulator, receiver
A9D66_16195	COG2353	YceI-like domain
A9D66_16215	COG1760	l-serine dehydratase
A9D66_16225	COG0460	homoserine dehydrogenase
A9D66_16225	COG0527	aspartate kinase activity
A9D66_16230	COG0626	cystathionine gamma-synthase activity
A9D66_16235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A9D66_16240	COG0739	heme binding
A9D66_16245	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A9D66_16250	COG1272	protein, Hemolysin III
A9D66_16255	COG2982	Protein involved in outer membrane biogenesis
A9D66_16260	COG0517	IMP dehydrogenase activity
A9D66_16260	COG0516	GMP reductase activity
A9D66_16265	COG0463	Glycosyl transferase, family 2
A9D66_16270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A9D66_16275	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A9D66_16285	COG4771	TonB-dependent receptor
A9D66_16290	COG1309	transcriptional regulator
A9D66_16295	COG2267	carboxylic ester hydrolase activity
A9D66_16300	COG1960	acyl-CoA dehydrogenase activity
A9D66_16325	COG0509	glycine decarboxylation via glycine cleavage system
A9D66_16330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A9D66_16340	COG0330	HflC and HflK could
A9D66_16345	COG1742	UPF0060 membrane protein
A9D66_16350	COG3956	TIGRFAM MazG family protein
A9D66_16360	COG0494	nUDIX hydrolase
A9D66_16370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A9D66_16375	COG0837	glucose binding
A9D66_16390	COG1388	LysM domain
A9D66_16390	COG3858	chitin binding
A9D66_16395	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A9D66_16405	COG1472	Belongs to the glycosyl hydrolase 3 family
A9D66_16420	COG0531	amino acid
A9D66_16430	COG1486	melibiose metabolic process
A9D66_16440	COG3537	Alpha-1,2-mannosidase
A9D66_16475	COG3142	Participates in the control of copper homeostasis
A9D66_16480	COG1446	asparaginase
A9D66_16510	COG0840	transmembrane signaling receptor activity
A9D66_16515	COG0835	chemotaxis
A9D66_16530	COG0189	ligase activity
A9D66_16540	COG1397	ADP-ribosylglycohydrolase
A9D66_16550	COG1199	ATP-dependent helicase activity
A9D66_16560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A9D66_16565	COG1215	transferase activity, transferring glycosyl groups
A9D66_16575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A9D66_16580	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A9D66_16585	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
A9D66_16590	COG0535	radical SAM domain protein
A9D66_16595	COG0535	radical SAM domain protein
A9D66_16610	COG0837	glucose binding
A9D66_16625	COG1643	Atp-dependent helicase
A9D66_16630	COG0783	Belongs to the Dps family
A9D66_16635	COG0514	ATP-dependent DNA helicase (RecQ)
A9D66_16665	COG0840	transmembrane signaling receptor activity
A9D66_16685	COG3920	Histidine kinase
A9D66_16690	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A9D66_16845	COG3179	chitinase
A9D66_16890	COG4695	Portal protein
A9D66_16925	COG0602	queuosine metabolic process
A9D66_16935	COG2885	chlorophyll binding
A9D66_16940	COG0823	Involved in the tonB-independent uptake of proteins
A9D66_16950	COG0848	biopolymer transport protein
A9D66_16960	COG0824	Thioesterase
A9D66_16965	COG2255	four-way junction helicase activity
A9D66_16975	COG3158	transport of potassium into the cell
A9D66_16980	COG0632	four-way junction helicase activity
A9D66_16985	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A9D66_16990	COG0217	transcriptional regulatory protein
A9D66_17005	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A9D66_17025	COG2801	Transposase and inactivated derivatives
A9D66_17030	COG2963	transposase activity
A9D66_17035	COG2801	Transposase and inactivated derivatives
A9D66_17040	COG2963	transposase activity
A9D66_17060	COG2801	Transposase and inactivated derivatives
A9D66_17065	COG2963	transposase activity
A9D66_17110	COG2951	lytic endotransglycosylase activity
A9D66_17120	COG0477	Major facilitator Superfamily
A9D66_17160	COG0488	(ABC) transporter
A9D66_17195	COG4651	solute:proton antiporter activity
A9D66_17195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A9D66_17220	COG4772	TonB-dependent receptor
A9D66_17230	COG4264	IucA IucC family
A9D66_17245	COG0019	diaminopimelate decarboxylase activity
A9D66_17265	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A9D66_17275	COG1492	cobalamin metabolic process
A9D66_17285	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A9D66_17310	COG4206	TonB-dependent receptor
A9D66_17315	COG0542	response to heat
A9D66_17320	COG1116	anion transmembrane transporter activity
A9D66_17325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A9D66_17330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A9D66_17335	COG0667	Aldo Keto reductase
A9D66_17345	COG4771	TonB-dependent receptor
A9D66_17350	COG2827	Endonuclease containing a URI domain
A9D66_17390	COG1877	trehalose-phosphatase activity
A9D66_17410	COG0840	transmembrane signaling receptor activity
A9D66_17415	COG3011	Protein conserved in bacteria
A9D66_17430	COG0564	pseudouridine synthase activity
A9D66_17435	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A9D66_17445	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A9D66_17445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A9D66_17455	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A9D66_17460	COG0045	succinate-CoA ligase (ADP-forming) activity
A9D66_17490	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A9D66_17495	COG0237	dephospho-CoA kinase activity
A9D66_17510	COG5002	protein histidine kinase activity
A9D66_17515	COG0745	RESPONSE REGULATOR receiver
A9D66_17525	COG0189	ligase activity
A9D66_17610	COG3657	addiction module killer protein
A9D66_17640	COG3209	COG3209 Rhs family protein
A9D66_17685	COG2022	thiamine diphosphate biosynthetic process
A9D66_17690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A9D66_17695	COG3273	potassium ion transport
A9D66_17695	COG0471	metal ion transport
A9D66_17755	COG2205	protein histidine kinase activity
A9D66_17755	COG0784	Response regulator, receiver
A9D66_17760	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A9D66_17765	COG1609	Transcriptional regulator
A9D66_17785	COG5297	Belongs to the glycosyl hydrolase family 6
A9D66_17795	COG3250	beta-galactosidase activity
A9D66_17800	COG4948	Mandelate Racemase Muconate Lactonizing
A9D66_17815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A9D66_17825	COG0308	aminopeptidase N
A9D66_17830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A9D66_17840	COG2895	sulfate adenylyltransferase (ATP) activity
A9D66_17840	COG0529	Catalyzes the synthesis of activated sulfate
A9D66_17845	COG0175	sulfate reduction
A9D66_17850	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A9D66_17855	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A9D66_17860	COG0175	sulfate reduction
A9D66_17895	COG1648	precorrin-2 dehydrogenase activity
A9D66_17895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A9D66_17910	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A9D66_17915	COG3588	fructose-bisphosphate aldolase
A9D66_17920	COG0469	pyruvate kinase activity
A9D66_17930	COG0126	phosphoglycerate kinase activity
A9D66_17950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A9D66_17960	COG3047	cAMP biosynthetic process
A9D66_17965	COG3047	cAMP biosynthetic process
A9D66_17975	COG3453	Protein conserved in bacteria
A9D66_17975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A9D66_17980	COG0725	ABC transporter, periplasmic molybdate-binding protein
A9D66_17985	COG4149	molybdate abc transporter
A9D66_17990	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A9D66_18025	COG1376	ErfK ybiS ycfS ynhG family protein
A9D66_18030	COG0739	heme binding
A9D66_18040	COG4773	Receptor
A9D66_18055	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A9D66_18060	COG1301	dicarboxylic acid transport
A9D66_18070	COG2304	oxidoreductase activity
A9D66_18090	COG0714	Associated with various cellular activities
A9D66_18120	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A9D66_18135	COG0254	rRNA binding
A9D66_18145	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A9D66_18155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A9D66_18160	COG1758	RNA polymerase activity
A9D66_18165	COG0194	GDP metabolic process
A9D66_18170	COG1561	YicC-like family, N-terminal region
A9D66_18175	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A9D66_18185	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A9D66_18190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A9D66_18205	COG0006	proline dipeptidase activity
A9D66_18215	COG0006	proline dipeptidase activity
A9D66_18220	COG3079	Belongs to the UPF0149 family
A9D66_18240	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A9D66_18250	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A9D66_18260	COG2912	Transglutaminase-like superfamily
A9D66_18265	COG1773	rubredoxin
A9D66_18270	COG0352	thiamine-phosphate diphosphorylase activity
A9D66_18280	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A9D66_18295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A9D66_18325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A9D66_18330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A9D66_18340	COG1028	Short-chain dehydrogenase reductase Sdr
A9D66_18350	COG0671	phosphoesterase, PA-phosphatase related
A9D66_18355	COG3781	membrane
A9D66_18365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A9D66_18370	COG0563	adenylate kinase activity
A9D66_18385	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A9D66_18395	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A9D66_18420	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A9D66_18430	COG0840	transmembrane signaling receptor activity
A9D66_18435	COG0405	Gamma-glutamyltransferase
A9D66_18440	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A9D66_18460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A9D66_18465	COG0473	3-isopropylmalate dehydrogenase activity
A9D66_18470	COG0066	3-isopropylmalate dehydratase activity
A9D66_18475	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A9D66_18495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A9D66_18500	COG1538	Outer membrane efflux protein
A9D66_18505	COG1519	Transferase
A9D66_18510	COG1560	Kdo2-lipid A biosynthetic process
A9D66_18535	COG0281	malic enzyme
A9D66_18535	COG0280	phosphate acetyltransferase
A9D66_18540	COG1301	dicarboxylic acid transport
A9D66_18565	COG0583	DNA-binding transcription factor activity
A9D66_18570	COG0667	Aldo Keto reductase
A9D66_18585	COG2197	response regulator
A9D66_18590	COG1840	ABC-type Fe3 transport system, periplasmic component
A9D66_18595	COG0642	Histidine kinase
A9D66_18610	COG2851	Citrate transporter
A9D66_18615	COG1028	Short-chain dehydrogenase reductase Sdr
A9D66_18625	COG2211	Major facilitator Superfamily
A9D66_18650	COG1162	GTPase activity
A9D66_18670	COG4773	Receptor
A9D66_18675	COG0726	polysaccharide deacetylase
A9D66_18680	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A9D66_18695	COG3964	amidohydrolase
A9D66_18700	COG0402	S-adenosylhomocysteine deaminase activity
A9D66_18720	COG1307	EDD domain protein, DegV family
A9D66_18725	COG0242	peptide deformylase activity
A9D66_18745	COG0457	Tetratricopeptide repeat
A9D66_18750	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A9D66_18755	COG1215	transferase activity, transferring glycosyl groups
A9D66_18760	COG1215	transferase activity, transferring glycosyl groups
A9D66_18775	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A9D66_18825	COG2188	Transcriptional regulator
A9D66_18835	COG1450	Type ii and iii secretion system protein
A9D66_18850	COG3166	PFAM Fimbrial assembly family protein
A9D66_18855	COG3156	type II secretion system protein K
A9D66_18860	COG4795	General secretion pathway protein
A9D66_18865	COG2165	general secretion pathway protein
A9D66_18870	COG4970	Tfp pilus assembly protein FimT
A9D66_18875	COG2165	general secretion pathway protein
A9D66_18880	COG1459	type II secretion system
A9D66_18885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A9D66_18890	COG1404	Belongs to the peptidase S8 family
A9D66_18895	COG5295	Hep Hag repeat protein
A9D66_18900	COG1404	Belongs to the peptidase S8 family
A9D66_18905	COG5295	Hep Hag repeat protein
A9D66_18915	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A9D66_18915	COG0047	phosphoribosylformylglycinamidine synthase activity
A9D66_18920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A9D66_18925	COG4974	Belongs to the 'phage' integrase family
A9D66_18940	COG0795	lipopolysaccharide-transporting ATPase activity
A9D66_18950	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A9D66_18965	COG0525	valine-tRNA ligase activity
A9D66_18995	COG1183	phosphatidylcholine synthase activity
A9D66_19005	COG0442	prolyl-tRNA aminoacylation
A9D66_19020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A9D66_19025	COG1127	ABC transporter
A9D66_19030	COG3218	ABC-type transport auxiliary lipoprotein component
A9D66_19030	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A9D66_19060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A9D66_19065	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A9D66_19065	COG0662	Cupin 2, conserved barrel domain protein
A9D66_19095	COG2086	electron transfer activity
A9D66_19110	COG0463	Glycosyl transferase, family 2
A9D66_19130	COG2813	Specifically methylates the guanine in position
A9D66_19140	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A9D66_19145	COG0438	transferase activity, transferring glycosyl groups
A9D66_19165	COG0438	transferase activity, transferring glycosyl groups
A9D66_19175	COG0626	cystathionine gamma-synthase activity
A9D66_19205	COG0625	glutathione transferase activity
A9D66_19215	COG0513	Belongs to the DEAD box helicase family
A9D66_19225	COG4206	TonB-dependent receptor
A9D66_19230	COG0720	synthase
A9D66_19240	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A9D66_19250	COG1956	GAF domain-containing protein
A9D66_19260	COG2819	hydrolase of the alpha beta superfamily
A9D66_19270	COG0546	phosphoglycolate phosphatase activity
A9D66_19275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A9D66_19280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A9D66_19295	COG0339	signal peptide processing
A9D66_19350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A9D66_19355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9D66_19360	COG4591	ABC-type transport system involved in lipoprotein release permease component
A9D66_19360	COG1136	(ABC) transporter
A9D66_19365	COG0577	efflux transmembrane transporter activity
A9D66_19380	COG2204	response regulator
A9D66_19385	COG4191	Histidine kinase
A9D66_19390	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A9D66_19405	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A9D66_19410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A9D66_19415	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A9D66_19420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A9D66_19425	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A9D66_19430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A9D66_19440	COG0356	it plays a direct role in the translocation of protons across the membrane
A9D66_19460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A9D66_19470	COG0508	dehydrogenase complex catalyzes the overall conversion of
A9D66_19515	COG2011	ABC-type metal ion transport system permease component
A9D66_19520	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A9D66_19525	COG0697	spore germination
A9D66_19530	COG1666	GTP binding
A9D66_19540	COG2198	Histidine kinase
A9D66_19540	COG5002	protein histidine kinase activity
A9D66_19540	COG0784	Response regulator, receiver
A9D66_19565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A9D66_19575	COG2813	Specifically methylates the guanine in position
A9D66_19595	COG2205	protein histidine kinase activity
A9D66_19595	COG2202	Pas domain
A9D66_19615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A9D66_19620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A9D66_19625	COG1522	sequence-specific DNA binding
A9D66_19675	COG0842	Transport permease protein
A9D66_19680	COG1131	(ABC) transporter
A9D66_19685	COG0025	NhaP-type Na H and K H
A9D66_19690	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A9D66_19695	COG1573	uracil-dna glycosylase
A9D66_19705	COG3384	dioxygenase
A9D66_19715	COG0583	DNA-binding transcription factor activity
A9D66_19725	COG0667	Aldo Keto reductase
A9D66_19735	COG3590	peptidase
A9D66_19755	COG0531	amino acid
A9D66_19770	COG2972	Histidine kinase
A9D66_19785	COG3685	Protein conserved in bacteria
A9D66_19790	COG3546	catalase activity
A9D66_19835	COG1271	oxidase subunit
A9D66_19840	COG1294	oxidase, subunit
A9D66_19855	COG1028	Short-chain dehydrogenase reductase Sdr
A9D66_19860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A9D66_19880	COG1132	(ABC) transporter
A9D66_19895	COG1063	alcohol dehydrogenase
A9D66_19970	COG0251	oxidation-reduction process
A9D66_19985	COG0840	transmembrane signaling receptor activity
A9D66_20000	COG0583	DNA-binding transcription factor activity
A9D66_20005	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A9D66_20040	COG0024	Methionine aminopeptidase
A9D66_20120	COG0582	viral genome integration into host DNA
A9D66_20145	COG4695	Portal protein
A9D66_20190	COG3179	chitinase
A9D66_20375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A9D66_20380	COG1490	D-aminoacyl-tRNA deacylase activity
A9D66_20385	COG1560	Kdo2-lipid A biosynthetic process
A9D66_20440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A9D66_20440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A9D66_20445	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A9D66_20450	COG0242	peptide deformylase activity
A9D66_20455	COG1652	LysM domain
A9D66_20460	COG0758	DNA mediated transformation
A9D66_20480	COG1754	DNA topoisomerase type I activity
A9D66_20480	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A9D66_20485	COG0009	L-threonylcarbamoyladenylate synthase
A9D66_20500	COG1028	Short-chain dehydrogenase reductase Sdr
A9D66_20510	COG0616	signal peptide processing
A9D66_20515	COG0534	Mate efflux family protein
A9D66_20535	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A9D66_20540	COG0625	glutathione transferase activity
A9D66_20555	COG1252	NADH dehydrogenase
A9D66_20560	COG2860	membrane
A9D66_20565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A9D66_20570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A9D66_20575	COG2201	protein-glutamate methylesterase activity
A9D66_20580	COG2177	Part of the ABC transporter FtsEX involved in
A9D66_20585	COG2884	Cell division ATP-binding protein ftsE
A9D66_20595	COG3118	belongs to the thioredoxin family
A9D66_20600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A9D66_20605	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
A9D66_20610	COG0583	DNA-binding transcription factor activity
A9D66_20630	COG1652	LysM domain
A9D66_20635	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A9D66_20635	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A9D66_20640	COG1473	amidohydrolase
A9D66_20645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9D66_20650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A9D66_20660	COG5383	Protein conserved in bacteria
A9D66_20705	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A9D66_20710	COG3023	N-Acetylmuramoyl-L-alanine amidase
A9D66_20720	COG4948	Mandelate Racemase Muconate Lactonizing
A9D66_20730	COG0531	amino acid
A9D66_20745	COG4682	membrane
A9D66_20760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A9D66_20765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A9D66_20770	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A9D66_20775	COG1610	YqeY-like protein
A9D66_20780	COG1295	ribonuclease BN
A9D66_20785	COG0358	DNA primase activity
A9D66_20800	COG0109	protoheme IX farnesyltransferase activity
A9D66_20830	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A9D66_20840	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A9D66_20885	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A9D66_20890	COG0739	heme binding
A9D66_20895	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A9D66_20905	COG2211	Major facilitator Superfamily
A9D66_20910	COG0708	Exodeoxyribonuclease III
A9D66_20915	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A9D66_20925	COG1192	Involved in chromosome partitioning
A9D66_20930	COG1475	DNA binding
A9D66_20945	COG0463	Glycosyl transferase, family 2
A9D66_20965	COG0756	dUTP diphosphatase activity
A9D66_20970	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A9D66_20975	COG2003	Belongs to the UPF0758 family
A9D66_20980	COG0018	arginyl-trna synthetase
A9D66_20995	COG4221	oxidoreductase activity
A9D66_21010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A9D66_21020	COG1166	arginine decarboxylase activity
A9D66_21025	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A9D66_21045	COG3291	Pkd domain containing protein
A9D66_21045	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A9D66_21050	COG0347	Belongs to the P(II) protein family
A9D66_21060	COG0606	chelatase, subunit chli
A9D66_21075	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A9D66_21110	COG1690	Belongs to the RtcB family
A9D66_21150	COG1090	epimerase
A9D66_21155	COG0745	RESPONSE REGULATOR receiver
A9D66_21160	COG0642	Histidine kinase
A9D66_21185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A9D66_21210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A9D66_21215	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A9D66_21230	COG0753	catalase activity
A9D66_21245	COG2197	response regulator
A9D66_21250	COG4585	Histidine kinase
A9D66_21255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9D66_21260	COG1136	(ABC) transporter
A9D66_21285	COG0697	spore germination
A9D66_21300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A9D66_21305	COG0180	Tryptophanyl-tRNA synthetase
A9D66_21310	COG3237	CsbD-like
A9D66_21350	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A9D66_21385	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A9D66_21390	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A9D66_21390	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A9D66_21415	COG2205	protein histidine kinase activity
A9D66_21420	COG0745	RESPONSE REGULATOR receiver
A9D66_21430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A9D66_21450	COG1199	ATP-dependent helicase activity
A9D66_21465	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A9D66_21530	COG0625	glutathione transferase activity
A9D66_21575	COG4555	ABC transporter
A9D66_21585	COG1476	TRANSCRIPTIONal
A9D66_21630	COG0633	Ferredoxin
A9D66_21630	COG0543	2 iron, 2 sulfur cluster binding
A9D66_21635	COG1131	(ABC) transporter
A9D66_21640	COG0842	Transport permease protein
A9D66_21650	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A9D66_21685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A9D66_21690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A9D66_21700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A9D66_21700	COG1042	CoA-binding domain protein
A9D66_21700	COG0045	succinate-CoA ligase (ADP-forming) activity
A9D66_21705	COG2239	Acts as a magnesium transporter
A9D66_21720	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A9D66_21725	COG3387	PFAM Glycoside hydrolase 15-related
A9D66_21740	COG3100	YcgL domain-containing protein
A9D66_21745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A9D66_21755	COG0463	Glycosyl transferase, family 2
A9D66_21765	COG1028	Short-chain dehydrogenase reductase Sdr
A9D66_21800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A9D66_21815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A9D66_21840	COG0823	Involved in the tonB-independent uptake of proteins
A9D66_21840	COG4946	Tricorn protease homolog
A9D66_21840	COG1506	peptidase
A9D66_21855	COG0408	coproporphyrinogen oxidase activity
A9D66_21890	COG0515	serine threonine protein kinase
A9D66_21890	COG2815	serine threonine protein kinase
A9D66_21895	COG0631	protein serine/threonine phosphatase activity
A9D66_21930	COG3501	Rhs element vgr protein
A9D66_21975	COG2801	Transposase and inactivated derivatives
A9D66_21995	COG3039	Transposase
A9D66_22005	COG2801	Transposase and inactivated derivatives
A9D66_22090	COG0210	DNA helicase
A9D66_22105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A9D66_22110	COG0583	DNA-binding transcription factor activity
A9D66_22115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A9D66_22125	COG2159	amidohydrolase
A9D66_22130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A9D66_22135	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A9D66_22150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9D66_22170	COG0357	Ribosomal RNA small subunit methyltransferase G
A9D66_22175	COG3540	Alkaline phosphatase
A9D66_22185	COG2091	lysine biosynthetic process via aminoadipic acid
A9D66_22205	COG0708	Exodeoxyribonuclease III
A9D66_22210	COG1940	carbohydrate kinase activity
A9D66_22210	COG1846	Transcriptional regulator
A9D66_22220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A9D66_22230	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A9D66_22235	COG3162	membrane
A9D66_22245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A9D66_22275	COG3507	Belongs to the glycosyl hydrolase 43 family
A9D66_22295	COG1028	Short-chain dehydrogenase reductase Sdr
A9D66_22300	COG0179	Fumarylacetoacetate (FAA) hydrolase
A9D66_22305	COG4948	Mandelate Racemase Muconate Lactonizing
A9D66_22310	COG3254	rhamnose metabolic process
A9D66_22315	COG0738	Major facilitator superfamily
A9D66_22320	COG1414	Transcriptional regulator
A9D66_22325	COG1971	Probably functions as a manganese efflux pump
A9D66_22330	COG2205	protein histidine kinase activity
A9D66_22345	COG3459	Glycosyltransferase 36 associated
A9D66_22350	COG2211	Major facilitator Superfamily
A9D66_22355	COG3265	gluconokinase activity
A9D66_22360	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A9D66_22380	COG2911	Protein conserved in bacteria
A9D66_22385	COG0729	surface antigen
A9D66_22415	COG0752	glycyl-tRNA synthetase alpha subunit
A9D66_22420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A9D66_22430	COG0519	Catalyzes the synthesis of GMP from XMP
A9D66_22430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A9D66_22440	COG0805	protein transport
A9D66_22445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A9D66_22450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A9D66_22460	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A9D66_22480	COG2974	May be involved in recombination
A9D66_22485	COG0037	tRNA processing
A9D66_22490	COG2115	Belongs to the xylose isomerase family
A9D66_22500	COG3661	Belongs to the glycosyl hydrolase 67 family
A9D66_22510	COG4948	Mandelate Racemase Muconate Lactonizing
A9D66_22520	COG1472	Belongs to the glycosyl hydrolase 3 family
A9D66_22525	COG0246	Mannitol dehydrogenase
A9D66_22565	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A9D66_22600	COG3386	PFAM SMP-30 Gluconolaconase
A9D66_22610	COG3250	beta-galactosidase activity
A9D66_22615	COG1904	glucuronate isomerase
A9D66_22620	COG3693	PFAM glycoside hydrolase, family 10
A9D66_22630	COG3693	PFAM glycoside hydrolase, family 10
A9D66_22645	COG2211	Major facilitator Superfamily
A9D66_22685	COG2937	Belongs to the GPAT DAPAT family
A9D66_22720	COG0284	orotidine-5'-phosphate decarboxylase activity
A9D66_22725	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A9D66_22730	COG3132	Protein of unknown function, DUF480
A9D66_22745	COG0210	DNA helicase
A9D66_22750	COG1435	thymidine kinase activity
A9D66_22760	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A9D66_22770	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A9D66_22800	COG3135	benzoate transporter
A9D66_22820	COG0676	glucose-6-phosphate 1-epimerase activity
A9D66_22830	COG3012	SEC-C Motif Domain Protein
A9D66_22835	COG0730	response to heat
A9D66_22855	COG0302	gtp cyclohydrolase
A9D66_22870	COG1566	PFAM secretion protein HlyD family protein
A9D66_22880	COG1289	transmembrane transporter activity
A9D66_22885	COG0477	Major facilitator Superfamily
A9D66_22890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A9D66_22910	COG4691	Plasmid stability protein
A9D66_22915	COG1487	ribonuclease activity
A9D66_22940	COG0564	pseudouridine synthase activity
A9D66_22950	COG0439	Biotin carboxylase
A9D66_22985	COG1074	ATP-dependent DNA helicase activity
A9D66_22990	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A9D66_23005	COG1127	ABC transporter
A9D66_23010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A9D66_23015	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A9D66_23030	COG2853	Lipoprotein
A9D66_23040	COG0386	Belongs to the glutathione peroxidase family
A9D66_23050	COG1322	Protein conserved in bacteria
A9D66_23055	COG0604	alcohol dehydrogenase
A9D66_23060	COG0583	DNA-binding transcription factor activity
A9D66_23070	COG0625	glutathione transferase activity
A9D66_23080	COG0531	amino acid
A9D66_23085	COG3537	Alpha-1,2-mannosidase
A9D66_23095	COG3706	GGDEF domain
A9D66_23100	COG3835	regulator
A9D66_23105	COG1929	Belongs to the glycerate kinase type-1 family
A9D66_23110	COG2271	Major facilitator Superfamily
A9D66_23125	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A9D66_23130	COG0861	Integral membrane protein TerC family
A9D66_23140	COG0584	glycerophosphoryl diester phosphodiesterase
A9D66_23155	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A9D66_23160	COG0726	polysaccharide deacetylase
A9D66_23170	COG0706	membrane insertase activity
A9D66_23175	COG0594	ribonuclease P activity
A9D66_23180	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A9D66_23205	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A9D66_23215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain