locus-tag	class	description
LPY95_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LPY95_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LPY95_00020	COG0187	DNA topoisomerase II activity
LPY95_00030	COG0501	Belongs to the peptidase M48B family
LPY95_00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LPY95_00105	COG2003	Belongs to the UPF0758 family
LPY95_00190	COG0793	Belongs to the peptidase S41A family
LPY95_00195	COG4942	peptidase
LPY95_00205	COG2234	aminopeptidase activity
LPY95_00215	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPY95_00225	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPY95_00230	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPY95_00235	COG1064	alcohol dehydrogenase
LPY95_00250	COG0493	'glutamate synthase
LPY95_00255	COG0069	glutamate synthase activity
LPY95_00255	COG0070	glutamate synthase
LPY95_00255	COG0067	glutamate synthase
LPY95_00305	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LPY95_00320	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LPY95_00325	COG0297	glycogen (starch) synthase activity
LPY95_00325	COG0438	transferase activity, transferring glycosyl groups
LPY95_00345	COG0367	asparagine synthase
LPY95_00375	COG1132	(ABC) transporter
LPY95_00405	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LPY95_00490	COG1111	helicase
LPY95_00490	COG1205	dead DEAH box helicase
LPY95_00495	COG1272	protein, Hemolysin III
LPY95_00520	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_00575	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LPY95_00580	COG3710	Transcriptional regulator
LPY95_00600	COG2197	response regulator
LPY95_00605	COG4585	Histidine kinase
LPY95_00615	COG1304	FMN binding
LPY95_00665	COG0662	Cupin 2, conserved barrel domain protein
LPY95_00675	COG4772	TonB-dependent receptor
LPY95_00685	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LPY95_00715	COG0714	Associated with various cellular activities
LPY95_00760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPY95_00815	COG0366	Alpha amylase catalytic
LPY95_00820	COG0366	Alpha amylase catalytic
LPY95_00825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LPY95_00895	COG3704	protein secretion by the type IV secretion system
LPY95_00905	COG3504	Conjugal transfer protein
LPY95_00910	COG2948	multi-organism process
LPY95_00930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPY95_01000	COG3041	Addiction module toxin RelE StbE family
LPY95_01005	COG3077	Addiction module antitoxin, RelB DinJ family
LPY95_01025	COG1192	Involved in chromosome partitioning
LPY95_01050	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPY95_01055	COG3265	gluconokinase activity
LPY95_01060	COG2211	Major facilitator Superfamily
LPY95_01065	COG3459	Glycosyltransferase 36 associated
LPY95_01075	COG2205	protein histidine kinase activity
LPY95_01080	COG1971	Probably functions as a manganese efflux pump
LPY95_01085	COG1414	Transcriptional regulator
LPY95_01090	COG0738	Major facilitator superfamily
LPY95_01095	COG3254	rhamnose metabolic process
LPY95_01100	COG4948	Mandelate Racemase Muconate Lactonizing
LPY95_01105	COG0179	Fumarylacetoacetate (FAA) hydrolase
LPY95_01110	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_01155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LPY95_01165	COG3162	membrane
LPY95_01170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LPY95_01180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LPY95_01190	COG1940	carbohydrate kinase activity
LPY95_01190	COG1846	Transcriptional regulator
LPY95_01195	COG0708	Exodeoxyribonuclease III
LPY95_01210	COG2091	lysine biosynthetic process via aminoadipic acid
LPY95_01220	COG3540	Alkaline phosphatase
LPY95_01225	COG0357	Ribosomal RNA small subunit methyltransferase G
LPY95_01245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPY95_01270	COG2159	amidohydrolase
LPY95_01280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LPY95_01285	COG0583	DNA-binding transcription factor activity
LPY95_01290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPY95_01300	COG0210	DNA helicase
LPY95_01435	COG4106	trans-aconitate 2-methyltransferase activity
LPY95_01475	COG0631	protein serine/threonine phosphatase activity
LPY95_01480	COG2815	serine threonine protein kinase
LPY95_01480	COG0515	serine threonine protein kinase
LPY95_01515	COG0408	coproporphyrinogen oxidase activity
LPY95_01530	COG4946	Tricorn protease homolog
LPY95_01530	COG1506	peptidase
LPY95_01530	COG0823	Involved in the tonB-independent uptake of proteins
LPY95_01550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LPY95_01605	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_01620	COG0463	Glycosyl transferase, family 2
LPY95_01630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LPY95_01635	COG3100	YcgL domain-containing protein
LPY95_01650	COG3387	PFAM Glycoside hydrolase 15-related
LPY95_01655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LPY95_01670	COG2239	Acts as a magnesium transporter
LPY95_01685	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPY95_01690	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPY95_01725	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LPY95_01735	COG0842	Transport permease protein
LPY95_01740	COG1131	(ABC) transporter
LPY95_01745	COG0543	2 iron, 2 sulfur cluster binding
LPY95_01745	COG0633	Ferredoxin
LPY95_01790	COG1476	TRANSCRIPTIONal
LPY95_01800	COG4555	ABC transporter
LPY95_01835	COG0625	glutathione transferase activity
LPY95_01910	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LPY95_01925	COG1199	ATP-dependent helicase activity
LPY95_01945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPY95_01985	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LPY95_01985	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LPY95_01990	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LPY95_02020	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LPY95_02060	COG3237	CsbD-like
LPY95_02070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPY95_02085	COG0697	spore germination
LPY95_02110	COG1136	(ABC) transporter
LPY95_02115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPY95_02120	COG4585	Histidine kinase
LPY95_02125	COG2197	response regulator
LPY95_02140	COG0753	catalase activity
LPY95_02155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LPY95_02160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPY95_02185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPY95_02210	COG0642	Histidine kinase
LPY95_02220	COG1090	epimerase
LPY95_02255	COG1690	Belongs to the RtcB family
LPY95_02280	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LPY95_02295	COG0606	chelatase, subunit chli
LPY95_02330	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LPY95_02335	COG1166	arginine decarboxylase activity
LPY95_02340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LPY95_02340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LPY95_02355	COG4221	oxidoreductase activity
LPY95_02370	COG0018	arginyl-trna synthetase
LPY95_02375	COG2003	Belongs to the UPF0758 family
LPY95_02380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LPY95_02385	COG0756	dUTP diphosphatase activity
LPY95_02405	COG0463	Glycosyl transferase, family 2
LPY95_02420	COG1475	DNA binding
LPY95_02425	COG1192	Involved in chromosome partitioning
LPY95_02435	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LPY95_02440	COG0708	Exodeoxyribonuclease III
LPY95_02445	COG2211	Major facilitator Superfamily
LPY95_02455	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LPY95_02460	COG0739	heme binding
LPY95_02465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LPY95_02520	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
LPY95_02550	COG0109	protoheme IX farnesyltransferase activity
LPY95_02565	COG0358	DNA primase activity
LPY95_02570	COG1295	ribonuclease BN
LPY95_02575	COG1610	YqeY-like protein
LPY95_02590	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LPY95_02600	COG2133	pyrroloquinoline quinone binding
LPY95_02605	COG4682	membrane
LPY95_02620	COG0531	amino acid
LPY95_02630	COG4948	Mandelate Racemase Muconate Lactonizing
LPY95_02640	COG3023	N-Acetylmuramoyl-L-alanine amidase
LPY95_02645	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
LPY95_02685	COG5383	Protein conserved in bacteria
LPY95_02695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPY95_02700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPY95_02705	COG1473	amidohydrolase
LPY95_02710	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LPY95_02710	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LPY95_02735	COG0583	DNA-binding transcription factor activity
LPY95_02740	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LPY95_02745	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LPY95_02750	COG3118	belongs to the thioredoxin family
LPY95_02760	COG2884	Cell division ATP-binding protein ftsE
LPY95_02765	COG2177	Part of the ABC transporter FtsEX involved in
LPY95_02770	COG2201	protein-glutamate methylesterase activity
LPY95_02775	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LPY95_02780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPY95_02785	COG2860	membrane
LPY95_02790	COG1252	NADH dehydrogenase
LPY95_02805	COG0625	glutathione transferase activity
LPY95_02810	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LPY95_02830	COG0534	Mate efflux family protein
LPY95_02835	COG0616	signal peptide processing
LPY95_02845	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_02860	COG0009	L-threonylcarbamoyladenylate synthase
LPY95_02865	COG1754	DNA topoisomerase type I activity
LPY95_02865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LPY95_02885	COG0758	DNA mediated transformation
LPY95_02890	COG1652	LysM domain
LPY95_02895	COG0242	peptide deformylase activity
LPY95_02900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LPY95_02905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LPY95_02905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LPY95_02955	COG1560	Kdo2-lipid A biosynthetic process
LPY95_02960	COG1490	D-aminoacyl-tRNA deacylase activity
LPY95_02965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPY95_02980	COG0582	viral genome integration into host DNA
LPY95_03015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LPY95_03040	COG0024	Methionine aminopeptidase
LPY95_03080	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LPY95_03085	COG0583	DNA-binding transcription factor activity
LPY95_03175	COG1063	alcohol dehydrogenase
LPY95_03190	COG1132	(ABC) transporter
LPY95_03210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LPY95_03215	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_03230	COG1294	oxidase, subunit
LPY95_03235	COG1271	oxidase subunit
LPY95_03280	COG3546	catalase activity
LPY95_03285	COG3685	Protein conserved in bacteria
LPY95_03305	COG2972	Histidine kinase
LPY95_03320	COG0531	amino acid
LPY95_03340	COG3590	peptidase
LPY95_03350	COG0667	Aldo Keto reductase
LPY95_03360	COG0583	DNA-binding transcription factor activity
LPY95_03370	COG3384	dioxygenase
LPY95_03380	COG1573	uracil-dna glycosylase
LPY95_03385	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LPY95_03390	COG0025	NhaP-type Na H and K H
LPY95_03395	COG1131	(ABC) transporter
LPY95_03400	COG0842	Transport permease protein
LPY95_03455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LPY95_03460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LPY95_03480	COG2202	Pas domain
LPY95_03480	COG2205	protein histidine kinase activity
LPY95_03505	COG1187	pseudouridine synthase activity
LPY95_03510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPY95_03530	COG5002	protein histidine kinase activity
LPY95_03530	COG0784	Response regulator, receiver
LPY95_03530	COG2198	Histidine kinase
LPY95_03540	COG1666	GTP binding
LPY95_03545	COG0697	spore germination
LPY95_03550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LPY95_03555	COG2011	ABC-type metal ion transport system permease component
LPY95_03605	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPY95_03615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPY95_03635	COG0356	it plays a direct role in the translocation of protons across the membrane
LPY95_03645	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LPY95_03650	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LPY95_03655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LPY95_03660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LPY95_03665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LPY95_03670	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LPY95_03685	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LPY95_03690	COG4191	Histidine kinase
LPY95_03705	COG0577	efflux transmembrane transporter activity
LPY95_03710	COG0577	efflux transmembrane transporter activity
LPY95_03715	COG4591	ABC-type transport system involved in lipoprotein release permease component
LPY95_03715	COG1136	(ABC) transporter
LPY95_03720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPY95_03795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPY95_03800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LPY95_03815	COG2819	hydrolase of the alpha beta superfamily
LPY95_03825	COG1956	GAF domain-containing protein
LPY95_03830	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LPY95_03840	COG0720	synthase
LPY95_03845	COG4206	TonB-dependent receptor
LPY95_03855	COG0513	Belongs to the DEAD box helicase family
LPY95_03865	COG0625	glutathione transferase activity
LPY95_03895	COG0626	cystathionine gamma-synthase activity
LPY95_03900	COG0438	transferase activity, transferring glycosyl groups
LPY95_03920	COG0438	transferase activity, transferring glycosyl groups
LPY95_03925	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LPY95_03940	COG2813	Specifically methylates the guanine in position
LPY95_03960	COG0463	Glycosyl transferase, family 2
LPY95_03980	COG2086	electron transfer activity
LPY95_04010	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LPY95_04010	COG0662	Cupin 2, conserved barrel domain protein
LPY95_04015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPY95_04045	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LPY95_04045	COG3218	ABC-type transport auxiliary lipoprotein component
LPY95_04050	COG1127	ABC transporter
LPY95_04055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPY95_04070	COG0442	prolyl-tRNA aminoacylation
LPY95_04080	COG1183	phosphatidylcholine synthase activity
LPY95_04110	COG0525	valine-tRNA ligase activity
LPY95_04125	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LPY95_04150	COG4974	Belongs to the 'phage' integrase family
LPY95_04155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LPY95_04160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LPY95_04160	COG0047	phosphoribosylformylglycinamidine synthase activity
LPY95_04170	COG1404	Belongs to the peptidase S8 family
LPY95_04180	COG5295	Hep Hag repeat protein
LPY95_04185	COG1404	Belongs to the peptidase S8 family
LPY95_04190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LPY95_04195	COG1459	type II secretion system
LPY95_04200	COG2165	general secretion pathway protein
LPY95_04205	COG4970	Tfp pilus assembly protein FimT
LPY95_04210	COG2165	general secretion pathway protein
LPY95_04215	COG4795	General secretion pathway protein
LPY95_04220	COG3156	type II secretion system protein K
LPY95_04225	COG3166	PFAM Fimbrial assembly family protein
LPY95_04240	COG1450	Type ii and iii secretion system protein
LPY95_04255	COG2188	Transcriptional regulator
LPY95_04300	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LPY95_04315	COG1215	transferase activity, transferring glycosyl groups
LPY95_04320	COG1215	transferase activity, transferring glycosyl groups
LPY95_04325	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LPY95_04330	COG0457	Tetratricopeptide repeat
LPY95_04350	COG0242	peptide deformylase activity
LPY95_04355	COG1307	EDD domain protein, DegV family
LPY95_04375	COG0402	S-adenosylhomocysteine deaminase activity
LPY95_04380	COG3964	amidohydrolase
LPY95_04395	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LPY95_04400	COG0726	polysaccharide deacetylase
LPY95_04405	COG4773	Receptor
LPY95_04480	COG1162	GTPase activity
LPY95_04505	COG2211	Major facilitator Superfamily
LPY95_04510	COG1609	Transcriptional regulator
LPY95_04515	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_04520	COG2851	Citrate transporter
LPY95_04535	COG0642	Histidine kinase
LPY95_04545	COG2197	response regulator
LPY95_04560	COG0667	Aldo Keto reductase
LPY95_04565	COG0583	DNA-binding transcription factor activity
LPY95_04590	COG1301	dicarboxylic acid transport
LPY95_04595	COG0281	malic enzyme
LPY95_04595	COG0280	phosphate acetyltransferase
LPY95_04620	COG1560	Kdo2-lipid A biosynthetic process
LPY95_04625	COG1519	Transferase
LPY95_04630	COG1538	Outer membrane efflux protein
LPY95_04635	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPY95_04655	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LPY95_04660	COG0066	3-isopropylmalate dehydratase activity
LPY95_04665	COG0473	3-isopropylmalate dehydrogenase activity
LPY95_04670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LPY95_04690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LPY95_04695	COG0405	Gamma-glutamyltransferase
LPY95_04700	COG0840	transmembrane signaling receptor activity
LPY95_04710	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LPY95_04735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LPY95_04745	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LPY95_04765	COG0563	adenylate kinase activity
LPY95_04770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPY95_04780	COG3781	membrane
LPY95_04785	COG0671	phosphoesterase, PA-phosphatase related
LPY95_04795	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_04800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LPY95_04805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LPY95_04835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LPY95_04850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LPY95_04860	COG0352	thiamine-phosphate diphosphorylase activity
LPY95_04865	COG1773	rubredoxin
LPY95_04870	COG2912	Transglutaminase-like superfamily
LPY95_04880	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LPY95_04890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LPY95_04910	COG3079	Belongs to the UPF0149 family
LPY95_04915	COG0006	proline dipeptidase activity
LPY95_04925	COG0006	proline dipeptidase activity
LPY95_04940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LPY95_04945	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LPY95_04955	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LPY95_04960	COG1561	YicC-like family, N-terminal region
LPY95_04965	COG0194	GDP metabolic process
LPY95_04975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPY95_04985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LPY95_05010	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LPY95_05045	COG0714	Associated with various cellular activities
LPY95_05065	COG2304	oxidoreductase activity
LPY95_05075	COG1301	dicarboxylic acid transport
LPY95_05080	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LPY95_05090	COG0596	Alpha beta hydrolase
LPY95_05095	COG4773	Receptor
LPY95_05145	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LPY95_05150	COG4149	molybdate abc transporter
LPY95_05155	COG0725	ABC transporter, periplasmic molybdate-binding protein
LPY95_05160	COG3453	Protein conserved in bacteria
LPY95_05160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPY95_05170	COG3047	cAMP biosynthetic process
LPY95_05175	COG3047	cAMP biosynthetic process
LPY95_05185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LPY95_05205	COG0126	phosphoglycerate kinase activity
LPY95_05215	COG0469	pyruvate kinase activity
LPY95_05220	COG3588	fructose-bisphosphate aldolase
LPY95_05225	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LPY95_05240	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LPY95_05240	COG1648	precorrin-2 dehydrogenase activity
LPY95_05255	COG0784	Response regulator, receiver
LPY95_05255	COG2198	Histidine kinase
LPY95_05255	COG2205	protein histidine kinase activity
LPY95_05275	COG0175	sulfate reduction
LPY95_05280	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LPY95_05285	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LPY95_05290	COG0175	sulfate reduction
LPY95_05295	COG2895	sulfate adenylyltransferase (ATP) activity
LPY95_05295	COG0529	Catalyzes the synthesis of activated sulfate
LPY95_05305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPY95_05330	COG0308	aminopeptidase N
LPY95_05340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LPY95_05355	COG4948	Mandelate Racemase Muconate Lactonizing
LPY95_05360	COG3250	beta-galactosidase activity
LPY95_05370	COG1609	Transcriptional regulator
LPY95_05380	COG1970	mechanosensitive ion channel activity
LPY95_05400	COG3273	potassium ion transport
LPY95_05400	COG0471	metal ion transport
LPY95_05405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LPY95_05410	COG2022	thiamine diphosphate biosynthetic process
LPY95_05515	COG0189	ligase activity
LPY95_05525	COG0745	RESPONSE REGULATOR receiver
LPY95_05530	COG5002	protein histidine kinase activity
LPY95_05560	COG0237	dephospho-CoA kinase activity
LPY95_05565	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LPY95_05610	COG0045	succinate-CoA ligase (ADP-forming) activity
LPY95_05615	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LPY95_05630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LPY95_05630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPY95_05640	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPY95_05645	COG0564	pseudouridine synthase activity
LPY95_05665	COG0840	transmembrane signaling receptor activity
LPY95_05680	COG3387	PFAM Glycoside hydrolase 15-related
LPY95_05685	COG1877	trehalose-phosphatase activity
LPY95_05725	COG2827	Endonuclease containing a URI domain
LPY95_05730	COG4771	TonB-dependent receptor
LPY95_05740	COG0667	Aldo Keto reductase
LPY95_05745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LPY95_05750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LPY95_05755	COG1116	anion transmembrane transporter activity
LPY95_05760	COG0542	response to heat
LPY95_05765	COG4206	TonB-dependent receptor
LPY95_05785	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LPY95_05795	COG1492	cobalamin metabolic process
LPY95_05805	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LPY95_05830	COG0019	diaminopimelate decarboxylase activity
LPY95_05845	COG4264	IucA IucC family
LPY95_05855	COG4772	TonB-dependent receptor
LPY95_05880	COG4651	solute:proton antiporter activity
LPY95_05880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LPY95_05910	COG0488	(ABC) transporter
LPY95_05950	COG0477	Major facilitator Superfamily
LPY95_05965	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LPY95_05980	COG0217	transcriptional regulatory protein
LPY95_05985	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LPY95_05990	COG0632	four-way junction helicase activity
LPY95_05995	COG3158	transport of potassium into the cell
LPY95_06005	COG2255	four-way junction helicase activity
LPY95_06010	COG0824	Thioesterase
LPY95_06020	COG0848	biopolymer transport protein
LPY95_06030	COG0823	Involved in the tonB-independent uptake of proteins
LPY95_06035	COG2885	chlorophyll binding
LPY95_06045	COG0602	queuosine metabolic process
LPY95_06055	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LPY95_06060	COG3920	Histidine kinase
LPY95_06080	COG0840	transmembrane signaling receptor activity
LPY95_06110	COG0514	ATP-dependent DNA helicase (RecQ)
LPY95_06115	COG0783	Belongs to the Dps family
LPY95_06120	COG1643	Atp-dependent helicase
LPY95_06135	COG0837	glucose binding
LPY95_06150	COG0535	radical SAM domain protein
LPY95_06155	COG0535	radical SAM domain protein
LPY95_06160	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
LPY95_06165	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LPY95_06175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPY95_06185	COG1215	transferase activity, transferring glycosyl groups
LPY95_06190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPY95_06200	COG1199	ATP-dependent helicase activity
LPY95_06210	COG1397	ADP-ribosylglycohydrolase
LPY95_06220	COG0189	ligase activity
LPY95_06235	COG0835	chemotaxis
LPY95_06240	COG0840	transmembrane signaling receptor activity
LPY95_06265	COG1446	asparaginase
LPY95_06270	COG3142	Participates in the control of copper homeostasis
LPY95_06305	COG3537	Alpha-1,2-mannosidase
LPY95_06350	COG1472	Belongs to the glycosyl hydrolase 3 family
LPY95_06360	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LPY95_06365	COG1388	LysM domain
LPY95_06365	COG3858	chitin binding
LPY95_06380	COG0837	glucose binding
LPY95_06385	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LPY95_06395	COG0494	nUDIX hydrolase
LPY95_06405	COG3956	TIGRFAM MazG family protein
LPY95_06410	COG1742	UPF0060 membrane protein
LPY95_06430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LPY95_06435	COG0509	glycine decarboxylation via glycine cleavage system
LPY95_06465	COG1960	acyl-CoA dehydrogenase activity
LPY95_06475	COG1309	transcriptional regulator
LPY95_06505	COG4771	TonB-dependent receptor
LPY95_06515	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LPY95_06520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPY95_06525	COG0463	Glycosyl transferase, family 2
LPY95_06530	COG0517	IMP dehydrogenase activity
LPY95_06530	COG0516	GMP reductase activity
LPY95_06535	COG2982	Protein involved in outer membrane biogenesis
LPY95_06540	COG1272	protein, Hemolysin III
LPY95_06545	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LPY95_06550	COG0739	heme binding
LPY95_06555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPY95_06560	COG0626	cystathionine gamma-synthase activity
LPY95_06565	COG0527	aspartate kinase activity
LPY95_06565	COG0460	homoserine dehydrogenase
LPY95_06575	COG1760	l-serine dehydratase
LPY95_06595	COG2353	YceI-like domain
LPY95_06600	COG2205	protein histidine kinase activity
LPY95_06600	COG0784	Response regulator, receiver
LPY95_06600	COG2198	Histidine kinase
LPY95_06605	COG5002	protein histidine kinase activity
LPY95_06605	COG0784	Response regulator, receiver
LPY95_06605	COG2198	Histidine kinase
LPY95_06625	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LPY95_06635	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LPY95_06640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LPY95_06645	COG0259	pyridoxamine-phosphate oxidase activity
LPY95_06655	COG1842	Phage shock protein A
LPY95_06680	COG0754	glutathionylspermidine amidase activity
LPY95_06765	COG0531	amino acid
LPY95_06775	COG2197	response regulator
LPY95_06805	COG1113	amino acid transport
LPY95_06815	COG1271	oxidase subunit
LPY95_06820	COG1294	oxidase, subunit
LPY95_06835	COG2239	Acts as a magnesium transporter
LPY95_06840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LPY95_06845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LPY95_06855	COG1660	Displays ATPase and GTPase activities
LPY95_06860	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LPY95_06865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LPY95_06880	COG1137	ATPase activity
LPY95_06885	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LPY95_06895	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LPY95_06905	COG0271	Belongs to the BolA IbaG family
LPY95_06910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LPY95_06930	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LPY95_06945	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LPY95_06955	COG0628	permease
LPY95_06965	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LPY95_06970	COG3178	'Phosphotransferase
LPY95_06985	COG1555	photosystem II stabilization
LPY95_07000	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LPY95_07005	COG1477	protein flavinylation
LPY95_07030	COG3128	pkhd-type hydroxylase
LPY95_07035	COG4774	siderophore transport
LPY95_07040	COG2146	nitrite reductase [NAD(P)H] activity
LPY95_07050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LPY95_07055	COG0719	Fe-S assembly protein
LPY95_07060	COG0396	ATPase activity
LPY95_07065	COG0719	Fe-S assembly protein
LPY95_07070	COG1959	2 iron, 2 sulfur cluster binding
LPY95_07080	COG0693	protein deglycase activity
LPY95_07100	COG0739	heme binding
LPY95_07120	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LPY95_07145	COG0519	Catalyzes the synthesis of GMP from XMP
LPY95_07150	COG1678	Uncharacterized ACR, COG1678
LPY95_07155	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LPY95_07160	COG0540	Belongs to the ATCase OTCase family
LPY95_07165	COG1764	response to oxidative stress
LPY95_07175	COG0384	phenazine biosynthesis protein PhzF
LPY95_07180	COG0384	phenazine biosynthesis protein PhzF
LPY95_07185	COG0527	aspartate kinase activity
LPY95_07200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LPY95_07215	COG0142	geranyltranstransferase activity
LPY95_07220	COG0629	single-stranded DNA binding
LPY95_07225	COG5001	Diguanylate cyclase
LPY95_07225	COG4251	negative regulation of phosphorylation
LPY95_07225	COG2203	Gaf domain
LPY95_07225	COG3706	GGDEF domain
LPY95_07230	COG3321	synthase
LPY95_07230	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_07230	COG0604	alcohol dehydrogenase
LPY95_07235	COG2080	2 iron, 2 sulfur cluster binding
LPY95_07240	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LPY95_07245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LPY95_07250	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LPY95_07285	COG2879	small protein
LPY95_07290	COG1966	Carbon starvation protein
LPY95_07295	COG1741	Belongs to the pirin family
LPY95_07310	COG1741	Belongs to the pirin family
LPY95_07320	COG1515	deoxyribonuclease V activity
LPY95_07325	COG0588	phosphoglycerate mutase activity
LPY95_07335	COG3590	peptidase
LPY95_07340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPY95_07345	COG2201	protein-glutamate methylesterase activity
LPY95_07350	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LPY95_07355	COG2199	diguanylate cyclase activity
LPY95_07355	COG2200	EAL domain
LPY95_07355	COG2202	Pas domain
LPY95_07360	COG0835	chemotaxis
LPY95_07370	COG0643	Histidine kinase
LPY95_07370	COG2198	Histidine kinase
LPY95_07400	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LPY95_07410	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LPY95_07415	COG0745	RESPONSE REGULATOR receiver
LPY95_07420	COG2205	protein histidine kinase activity
LPY95_07435	COG4452	Inner membrane protein CreD
LPY95_07460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPY95_07465	COG0735	belongs to the Fur family
LPY95_07480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPY95_07495	COG0667	Aldo Keto reductase
LPY95_07510	COG2207	Transcriptional regulator
LPY95_07520	COG0583	DNA-binding transcription factor activity
LPY95_07525	COG2814	Major facilitator Superfamily
LPY95_07650	COG5001	Diguanylate cyclase
LPY95_07650	COG5002	protein histidine kinase activity
LPY95_07655	COG1187	pseudouridine synthase activity
LPY95_07675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LPY95_07685	COG0475	glutathione-regulated potassium exporter activity
LPY95_07695	COG0745	RESPONSE REGULATOR receiver
LPY95_07700	COG1538	Outer membrane efflux protein
LPY95_07730	COG1132	(ABC) transporter
LPY95_07775	COG2155	Conserved Protein
LPY95_07810	COG3118	belongs to the thioredoxin family
LPY95_07820	COG0495	leucyl-tRNA aminoacylation
LPY95_07835	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LPY95_07850	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LPY95_07865	COG2968	Membrane
LPY95_07870	COG0424	maF-like protein
LPY95_07880	COG3164	Protein of unknown function
LPY95_07890	COG0312	modulator of DNA gyrase
LPY95_07895	COG3028	Belongs to the UPF0307 family
LPY95_07900	COG0312	modulator of DNA gyrase
LPY95_07910	COG4104	PAAR repeat-containing protein
LPY95_07915	COG0142	geranyltranstransferase activity
LPY95_07920	COG1722	exodeoxyribonuclease VII activity
LPY95_07925	COG0037	tRNA processing
LPY95_07930	COG1785	Belongs to the alkaline phosphatase family
LPY95_07935	COG1301	dicarboxylic acid transport
LPY95_07940	COG4106	trans-aconitate 2-methyltransferase activity
LPY95_07950	COG0791	NLP P60 protein
LPY95_07955	COG0791	NLP P60 protein
LPY95_07960	COG1047	Peptidyl-prolyl cis-trans
LPY95_07965	COG2311	Membrane
LPY95_07970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LPY95_07975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPY95_07995	COG3590	peptidase
LPY95_08000	COG3590	peptidase
LPY95_08020	COG0489	protein tyrosine kinase activity
LPY95_08025	COG0717	Belongs to the dCTP deaminase family
LPY95_08065	COG1404	Belongs to the peptidase S8 family
LPY95_08070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LPY95_08080	COG2336	PFAM SpoVT AbrB
LPY95_08095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LPY95_08100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPY95_08115	COG0494	nUDIX hydrolase
LPY95_08120	COG0433	COG0433 Predicted ATPase
LPY95_08135	COG0688	phosphatidylethanolamine metabolic process
LPY95_08145	COG2890	protein-(glutamine-N5) methyltransferase activity
LPY95_08150	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LPY95_08155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LPY95_08160	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LPY95_08180	COG0101	tRNA pseudouridine synthase activity
LPY95_08185	COG0135	phosphoribosylanthranilate isomerase activity
LPY95_08195	COG0133	tryptophan synthase activity
LPY95_08205	COG0159	tryptophan synthase activity
LPY95_08210	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LPY95_08215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPY95_08245	COG0300	oxidoreductase activity
LPY95_08250	COG0149	triose-phosphate isomerase activity
LPY95_08265	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPY95_08270	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPY95_08275	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPY95_08280	COG0649	NAD binding
LPY95_08285	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LPY95_08290	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LPY95_08300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LPY95_08305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPY95_08330	COG1007	ATP synthesis coupled electron transport
LPY95_08340	COG0779	Required for maturation of 30S ribosomal subunits
LPY95_08345	COG0195	Participates in both transcription termination and antitermination
LPY95_08350	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LPY95_08355	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LPY95_08360	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LPY95_08365	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LPY95_08370	COG1185	polyribonucleotide nucleotidyltransferase activity
LPY95_08405	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LPY95_08415	COG2095	MarC family integral membrane protein
LPY95_08425	COG1611	Belongs to the LOG family
LPY95_08485	COG3505	Type IV secretory pathway VirD4
LPY95_08505	COG2948	multi-organism process
LPY95_08525	COG3702	type iv secretory pathway
LPY95_08595	COG1082	Xylose isomerase domain protein TIM barrel
LPY95_08600	COG0438	transferase activity, transferring glycosyl groups
LPY95_08620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LPY95_08625	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LPY95_08640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LPY95_08645	COG0072	phenylalanine-tRNA ligase activity
LPY95_08645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPY95_08695	COG0438	transferase activity, transferring glycosyl groups
LPY95_08700	COG0438	transferase activity, transferring glycosyl groups
LPY95_08710	COG0438	transferase activity, transferring glycosyl groups
LPY95_08735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPY95_08740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPY95_08745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPY95_08765	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LPY95_08775	COG1960	acyl-CoA dehydrogenase activity
LPY95_08790	COG3040	lipid binding
LPY95_08805	COG0322	excinuclease ABC activity
LPY95_08820	COG4191	Histidine kinase
LPY95_08820	COG0784	Response regulator, receiver
LPY95_08825	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LPY95_08830	COG1194	a g-specific adenine glycosylase
LPY95_08835	COG0552	protein localization to endoplasmic reticulum
LPY95_08845	COG3938	Belongs to the proline racemase family
LPY95_08850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LPY95_08865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LPY95_08875	COG0006	proline dipeptidase activity
LPY95_08890	COG0531	amino acid
LPY95_08945	COG4206	TonB-dependent receptor
LPY95_08980	COG0326	Molecular chaperone. Has ATPase activity
LPY95_08985	COG0742	ribosomal rna small subunit methyltransferase
LPY95_08990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LPY95_09000	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LPY95_09005	COG0405	Gamma-glutamyltransferase
LPY95_09010	COG3291	Pkd domain containing protein
LPY95_09015	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LPY95_09060	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LPY95_09065	COG0343	queuine tRNA-ribosyltransferase activity
LPY95_09070	COG1862	Preprotein translocase
LPY95_09080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPY95_09140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LPY95_09140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LPY95_09145	COG1105	Belongs to the carbohydrate kinase PfkB family
LPY95_09150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LPY95_09150	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LPY95_09155	COG1609	Transcriptional regulator
LPY95_09160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPY95_09165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPY95_09175	COG2902	Dehydrogenase
LPY95_09185	COG0477	Major facilitator Superfamily
LPY95_09195	COG2205	protein histidine kinase activity
LPY95_09195	COG0784	Response regulator, receiver
LPY95_09195	COG5002	protein histidine kinase activity
LPY95_09200	COG2733	membrane
LPY95_09210	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LPY95_09215	COG2223	nitrite transmembrane transporter activity
LPY95_09220	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LPY95_09225	COG0243	molybdopterin cofactor binding
LPY95_09235	COG0477	Major facilitator Superfamily
LPY95_09240	COG2703	oxygen carrier activity
LPY95_09250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LPY95_09255	COG0174	glutamine synthetase
LPY95_09260	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LPY95_09275	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LPY95_09295	COG3842	ATPase activity
LPY95_09300	COG1176	ABC-type spermidine putrescine transport system, permease component I
LPY95_09305	COG1177	transmembrane transport
LPY95_09310	COG1012	belongs to the aldehyde dehydrogenase family
LPY95_09325	COG4535	Mg2 and Co2 transporter CorC
LPY95_09335	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LPY95_09345	COG1702	phosphate starvation-inducible protein PhoH
LPY95_09350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LPY95_09365	COG0741	lytic transglycosylase activity
LPY95_09370	COG0723	plastoquinol--plastocyanin reductase activity
LPY95_09375	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LPY95_09380	COG2857	Cytochrome c1
LPY95_09385	COG0625	glutathione transferase activity
LPY95_09390	COG2969	positive regulation of protein catabolic process
LPY95_09410	COG1201	RNA secondary structure unwinding
LPY95_09415	COG2094	Belongs to the DNA glycosylase MPG family
LPY95_09420	COG0840	transmembrane signaling receptor activity
LPY95_09425	COG0835	chemotaxis
LPY95_09550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LPY95_09560	COG1570	exodeoxyribonuclease VII activity
LPY95_09565	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LPY95_09570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LPY95_09570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LPY95_09575	COG0802	atpase or kinase
LPY95_09580	COG0860	N-Acetylmuramoyl-L-alanine amidase
LPY95_09585	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LPY95_09610	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_09615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPY95_09620	COG0501	Belongs to the peptidase M48B family
LPY95_09630	COG2081	HI0933 family
LPY95_09635	COG4681	YaeQ
LPY95_09645	COG0625	glutathione transferase activity
LPY95_09655	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LPY95_09660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LPY95_09665	COG0513	Belongs to the DEAD box helicase family
LPY95_09670	COG0488	(ABC) transporter
LPY95_09685	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LPY95_09690	COG0483	inositol monophosphate 1-phosphatase activity
LPY95_09705	COG5001	Diguanylate cyclase
LPY95_09705	COG3300	MHYT domain
LPY95_09710	COG1509	lysine 2,3-aminomutase activity
LPY95_09715	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LPY95_09725	COG0402	S-adenosylhomocysteine deaminase activity
LPY95_09730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LPY95_09790	COG4302	ethanolamine ammonia-lyase activity
LPY95_09815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LPY95_09820	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LPY95_09840	COG2166	iron-sulfur cluster assembly
LPY95_09845	COG0215	cysteine-tRNA ligase activity
LPY95_09855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LPY95_09860	COG0137	argininosuccinate synthase activity
LPY95_09870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LPY95_09875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LPY95_09885	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LPY95_09890	COG0165	Argininosuccinate lyase
LPY95_09900	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LPY95_09905	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LPY95_09930	COG1294	oxidase, subunit
LPY95_09940	COG4988	ABC transporter
LPY95_09945	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LPY95_09950	COG1278	Cold shock
LPY95_09955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPY95_09975	COG1138	Cytochrome C-type biogenesis protein
LPY95_09980	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LPY95_10000	COG4133	protoheme IX ABC transporter activity
LPY95_10005	COG0436	Aminotransferase
LPY95_10025	COG1187	pseudouridine synthase activity
LPY95_10030	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LPY95_10035	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LPY95_10040	COG2350	Protein conserved in bacteria
LPY95_10070	COG1175	transmembrane transport
LPY95_10075	COG0395	ABC-type sugar transport system, permease component
LPY95_10100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPY95_10105	COG2957	Belongs to the agmatine deiminase family
LPY95_10120	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LPY95_10125	COG0539	negative regulation of cytoplasmic translation
LPY95_10130	COG0776	regulation of translation
LPY95_10140	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LPY95_10155	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LPY95_10160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LPY95_10160	COG0475	glutathione-regulated potassium exporter activity
LPY95_10170	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LPY95_10180	COG0519	Catalyzes the synthesis of GMP from XMP
LPY95_10180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LPY95_10185	COG0582	viral genome integration into host DNA
LPY95_10230	COG0667	Aldo Keto reductase
LPY95_10275	COG3451	type IV secretory pathway VirB4
LPY95_10290	COG3846	protein secretion by the type IV secretion system
LPY95_10315	COG3002	Belongs to the UPF0753 family
LPY95_10320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LPY95_10345	COG2197	response regulator
LPY95_10365	COG1335	isochorismatase
LPY95_10375	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LPY95_10390	COG1914	H( )-stimulated, divalent metal cation uptake system
LPY95_10410	COG2814	Major facilitator Superfamily
LPY95_10420	COG0668	transmembrane transport
LPY95_10430	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LPY95_10445	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_10450	COG1183	phosphatidylcholine synthase activity
LPY95_10460	COG3243	poly(R)-hydroxyalkanoic acid synthase
LPY95_10475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LPY95_10475	COG0723	plastoquinol--plastocyanin reductase activity
LPY95_10485	COG2183	response to ionizing radiation
LPY95_10490	COG0784	Response regulator, receiver
LPY95_10490	COG2205	protein histidine kinase activity
LPY95_10565	COG0800	Aldolase
LPY95_10570	COG0129	dihydroxy-acid dehydratase activity
LPY95_10575	COG0363	glucosamine-6-phosphate deaminase activity
LPY95_10580	COG0837	glucose binding
LPY95_10585	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LPY95_10610	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LPY95_10625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LPY95_10630	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LPY95_10640	COG4591	ABC-type transport system involved in lipoprotein release permease component
LPY95_10645	COG1136	(ABC) transporter
LPY95_10660	COG0811	peptide transport
LPY95_10670	COG1132	(ABC) transporter
LPY95_10675	COG1663	tetraacyldisaccharide 4'-kinase activity
LPY95_10680	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LPY95_10685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LPY95_10695	COG0322	excinuclease ABC activity
LPY95_10700	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LPY95_10720	COG0582	viral genome integration into host DNA
LPY95_10735	COG0583	DNA-binding transcription factor activity
LPY95_10765	COG1074	ATP-dependent DNA helicase activity
LPY95_10770	COG3593	DNA synthesis involved in DNA repair
LPY95_10985	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LPY95_11005	COG1054	Belongs to the UPF0176 family
LPY95_11015	COG1530	ribonuclease E activity
LPY95_11025	COG3064	Membrane
LPY95_11030	COG0428	transporter
LPY95_11040	COG2154	pterin-4-alpha-carbinolamine dehydratase
LPY95_11045	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LPY95_11045	COG0316	Belongs to the HesB IscA family
LPY95_11165	COG1238	metal cluster binding
LPY95_11200	COG3279	Response regulator of the LytR AlgR family
LPY95_11220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPY95_11240	COG4566	intracellular signal transduction
LPY95_11265	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LPY95_11350	COG4644	lycopene metabolic process
LPY95_11385	COG4456	Virulence-associated protein
LPY95_11395	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LPY95_11550	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LPY95_11555	COG0303	'Molybdopterin
LPY95_11565	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPY95_11575	COG1426	Protein conserved in bacteria
LPY95_11585	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LPY95_11600	COG1250	3-hydroxyacyl-CoA dehydrogenase
LPY95_11600	COG1024	Enoyl-CoA hydratase
LPY95_11605	COG0183	Belongs to the thiolase family
LPY95_11610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LPY95_11615	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LPY95_11625	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LPY95_11635	COG1674	ftsk spoiiie
LPY95_11640	COG0492	ferredoxin-NADP+ reductase activity
LPY95_11650	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LPY95_11660	COG0542	response to heat
LPY95_11675	COG0482	sulfurtransferase activity
LPY95_11680	COG2915	High frequency lysogenization protein hflD homolog
LPY95_11710	COG5002	protein histidine kinase activity
LPY95_11730	COG0784	Response regulator, receiver
LPY95_11730	COG0835	chemotaxis
LPY95_11740	COG1558	bacterial-type flagellum-dependent cell motility
LPY95_11745	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LPY95_11755	COG4787	bacterial-type flagellum-dependent cell motility
LPY95_11770	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LPY95_11775	COG1706	bacterial-type flagellum-dependent cell motility
LPY95_11780	COG3951	Flagellar rod assembly protein muramidase FlgJ
LPY95_11780	COG1705	Flagellar rod assembly protein muramidase FlgJ
LPY95_11790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LPY95_11795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LPY95_11805	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LPY95_11825	COG2197	response regulator
LPY95_11835	COG2201	protein-glutamate methylesterase activity
LPY95_11855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPY95_11860	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_11865	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_11910	COG1677	Flagellar hook-basal body complex protein FliE
LPY95_11960	COG3190	flagellar
LPY95_11975	COG1684	flagellar biosynthetic protein fliR
LPY95_12000	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LPY95_12030	COG0643	Histidine kinase
LPY95_12030	COG0784	Response regulator, receiver
LPY95_12030	COG2198	Histidine kinase
LPY95_12100	COG1192	Involved in chromosome partitioning
LPY95_12115	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LPY95_12120	COG1360	Flagellar Motor Protein
LPY95_12130	COG0835	chemotaxis
LPY95_12140	COG0745	RESPONSE REGULATOR receiver
LPY95_12150	COG0840	transmembrane signaling receptor activity
LPY95_12170	COG0840	transmembrane signaling receptor activity
LPY95_12180	COG0840	transmembrane signaling receptor activity
LPY95_12185	COG0840	transmembrane signaling receptor activity
LPY95_12190	COG0840	transmembrane signaling receptor activity
LPY95_12205	COG0840	transmembrane signaling receptor activity
LPY95_12210	COG0840	transmembrane signaling receptor activity
LPY95_12215	COG0840	transmembrane signaling receptor activity
LPY95_12225	COG0840	transmembrane signaling receptor activity
LPY95_12235	COG0835	chemotaxis
LPY95_12245	COG0840	transmembrane signaling receptor activity
LPY95_12255	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LPY95_12260	COG2201	protein-glutamate methylesterase activity
LPY95_12270	COG2267	carboxylic ester hydrolase activity
LPY95_12300	COG0318	PFAM AMP-dependent synthetase and ligase
LPY95_12305	COG1024	Enoyl-CoA hydratase
LPY95_12310	COG0784	Response regulator, receiver
LPY95_12310	COG2198	Histidine kinase
LPY95_12310	COG2205	protein histidine kinase activity
LPY95_12320	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LPY95_12330	COG3279	Response regulator of the LytR AlgR family
LPY95_12365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LPY95_12375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPY95_12380	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LPY95_12390	COG0505	Belongs to the CarA family
LPY95_12395	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LPY95_12400	COG2258	MOSC domain
LPY95_12405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LPY95_12450	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LPY95_12470	COG0277	FAD linked oxidase domain protein
LPY95_12475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LPY95_12485	COG0531	amino acid
LPY95_12490	COG0531	amino acid
LPY95_12495	COG0235	Class ii aldolase
LPY95_12500	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LPY95_12505	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LPY95_12520	COG0140	phosphoribosyl-ATP diphosphatase activity
LPY95_12520	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LPY95_12525	COG0107	imidazoleglycerol-phosphate synthase activity
LPY95_12530	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LPY95_12535	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LPY95_12540	COG0131	Imidazoleglycerol-phosphate dehydratase
LPY95_12540	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LPY95_12545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LPY95_12550	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LPY95_12555	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LPY95_12565	COG0124	histidyl-tRNA synthetase
LPY95_12570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LPY95_12625	COG1649	PFAM Uncharacterised BCR, COG1649
LPY95_12625	COG0726	polysaccharide deacetylase
LPY95_12630	COG1215	transferase activity, transferring glycosyl groups
LPY95_12645	COG1012	belongs to the aldehyde dehydrogenase family
LPY95_12660	COG0167	dihydroorotate dehydrogenase activity
LPY95_12665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LPY95_12675	COG1794	racemase activity, acting on amino acids and derivatives
LPY95_12690	COG0671	phosphoesterase, PA-phosphatase related
LPY95_12695	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LPY95_12705	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LPY95_12710	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPY95_12715	COG5001	Diguanylate cyclase
LPY95_12715	COG2203	Gaf domain
LPY95_12715	COG4251	negative regulation of phosphorylation
LPY95_12715	COG3706	GGDEF domain
LPY95_12725	COG1472	Belongs to the glycosyl hydrolase 3 family
LPY95_12745	COG0166	Belongs to the GPI family
LPY95_12750	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LPY95_12755	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LPY95_12760	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LPY95_12780	COG1469	GTP cyclohydrolase I activity
LPY95_12785	COG0860	N-Acetylmuramoyl-L-alanine amidase
LPY95_12805	COG0477	Major facilitator Superfamily
LPY95_12810	COG2115	Belongs to the xylose isomerase family
LPY95_12815	COG1070	Carbohydrate kinase
LPY95_12825	COG1501	Belongs to the glycosyl hydrolase 31 family
LPY95_12860	COG0800	Aldolase
LPY95_12865	COG4948	Mandelate Racemase Muconate Lactonizing
LPY95_12875	COG3734	2-keto-3-deoxy-galactonokinase
LPY95_12880	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LPY95_12890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LPY95_12905	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LPY95_12910	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LPY95_12925	COG0351	phosphomethylpyrimidine kinase
LPY95_12950	COG0583	DNA-binding transcription factor activity
LPY95_12955	COG1741	Belongs to the pirin family
LPY95_12970	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LPY95_12975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LPY95_12980	COG2137	regulation of response to DNA damage stimulus
LPY95_12985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LPY95_12990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LPY95_12995	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LPY95_13000	COG1546	Belongs to the CinA family
LPY95_13005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LPY95_13015	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LPY95_13020	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LPY95_13030	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LPY95_13035	COG1534	Rna-binding protein
LPY95_13050	COG1238	metal cluster binding
LPY95_13055	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPY95_13060	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LPY95_13070	COG0585	pseudouridine synthase activity
LPY95_13075	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LPY95_13080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LPY95_13085	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LPY95_13090	COG0148	phosphopyruvate hydratase activity
LPY95_13100	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LPY95_13105	COG0504	CTP synthase activity
LPY95_13130	COG0306	phosphate transporter
LPY95_13140	COG1253	flavin adenine dinucleotide binding
LPY95_13155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LPY95_13160	COG0477	Major facilitator Superfamily
LPY95_13170	COG1136	(ABC) transporter
LPY95_13195	COG2264	protein methyltransferase activity
LPY95_13225	COG2244	polysaccharide biosynthetic process
LPY95_13295	COG2951	lytic endotransglycosylase activity
LPY95_13330	COG1595	DNA-templated transcription, initiation
LPY95_13345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LPY95_13355	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LPY95_13365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPY95_13380	COG0784	Response regulator, receiver
LPY95_13380	COG4191	Histidine kinase
LPY95_13415	COG0840	transmembrane signaling receptor activity
LPY95_13430	COG0583	DNA-binding transcription factor activity
LPY95_13435	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LPY95_13440	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LPY95_13460	COG0077	Prephenate dehydratase
LPY95_13460	COG1605	Chorismate mutase
LPY95_13465	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LPY95_13470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LPY95_13475	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LPY95_13515	COG1228	amidohydrolase
LPY95_13520	COG2986	histidine ammonia-lyase
LPY95_13530	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LPY95_13540	COG4993	Dehydrogenase
LPY95_13550	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LPY95_13560	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LPY95_13565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LPY95_13570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LPY95_13585	COG3115	cell septum assembly
LPY95_13595	COG0359	binds to the 23S rRNA
LPY95_13600	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LPY95_13605	COG0360	Binds together with S18 to 16S ribosomal RNA
LPY95_13610	COG0316	Belongs to the HesB IscA family
LPY95_13615	COG0017	Asparaginyl-tRNA synthetase
LPY95_13635	COG2808	Putative FMN-binding domain
LPY95_13705	COG0288	reversible hydration of carbon dioxide
LPY95_13710	COG0662	Cupin 2, conserved barrel domain protein
LPY95_13725	COG3844	kynureninase activity
LPY95_13730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPY95_13735	COG2925	Exonuclease
LPY95_13760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LPY95_13765	COG0116	Belongs to the methyltransferase superfamily
LPY95_13765	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LPY95_13775	COG0488	(ABC) transporter
LPY95_13810	COG0494	nUDIX hydrolase
LPY95_13820	COG1024	Enoyl-CoA hydratase
LPY95_13830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LPY95_13835	COG0659	secondary active sulfate transmembrane transporter activity
LPY95_13860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LPY95_13865	COG0573	inorganic phosphate transmembrane transporter activity
LPY95_13870	COG0581	inorganic phosphate transmembrane transporter activity
LPY95_13875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LPY95_13880	COG0704	Plays a role in the regulation of phosphate uptake
LPY95_13890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPY95_13910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LPY95_13920	COG0557	exoribonuclease II activity
LPY95_13935	COG1960	acyl-CoA dehydrogenase activity
LPY95_13940	COG2226	methyltransferase
LPY95_13945	COG0646	methionine synthase
LPY95_13945	COG1410	methionine synthase
LPY95_13950	COG0646	methionine synthase
LPY95_13950	COG1410	methionine synthase
LPY95_13960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LPY95_13985	COG2900	Belongs to the SlyX family
LPY95_14000	COG0386	Belongs to the glutathione peroxidase family
LPY95_14010	COG1725	Transcriptional regulator
LPY95_14015	COG1131	(ABC) transporter
LPY95_14045	COG1253	flavin adenine dinucleotide binding
LPY95_14065	COG2850	peptidyl-arginine hydroxylation
LPY95_14100	COG1132	(ABC) transporter
LPY95_14105	COG0583	DNA-binding transcription factor activity
LPY95_14140	COG0484	heat shock protein binding
LPY95_14145	COG0443	Heat shock 70 kDa protein
LPY95_14150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LPY95_14155	COG1420	regulation of RNA biosynthetic process
LPY95_14160	COG0497	DNA recombination
LPY95_14170	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPY95_14185	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LPY95_14255	COG3706	GGDEF domain
LPY95_14300	COG0583	DNA-binding transcription factor activity
LPY95_14310	COG0415	Belongs to the DNA photolyase family
LPY95_14315	COG0305	Participates in initiation and elongation during chromosome replication
LPY95_14325	COG0367	asparagine synthase
LPY95_14345	COG1960	acyl-CoA dehydrogenase activity
LPY95_14360	COG0084	hydrolase, TatD family'
LPY95_14365	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LPY95_14425	COG0386	Belongs to the glutathione peroxidase family
LPY95_14430	COG0339	signal peptide processing
LPY95_14480	COG2814	Major facilitator Superfamily
LPY95_14485	COG1566	PFAM secretion protein HlyD family protein
LPY95_14510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LPY95_14525	COG4774	siderophore transport
LPY95_14535	COG0367	asparagine synthase
LPY95_14540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LPY95_14545	COG1393	Belongs to the ArsC family
LPY95_14595	COG0052	Belongs to the universal ribosomal protein uS2 family
LPY95_14600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LPY95_14610	COG0528	UMP kinase activity
LPY95_14615	COG0233	cytoplasmic translational termination
LPY95_14620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LPY95_14625	COG0575	Belongs to the CDS family
LPY95_14630	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LPY95_14635	COG0750	zinc metalloprotease
LPY95_14650	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPY95_14655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPY95_14660	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPY95_14665	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPY95_14670	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LPY95_14680	COG0825	malonyl-CoA metabolic process
LPY95_14695	COG1981	membrane
LPY95_14715	COG1695	Transcriptional regulator
LPY95_14735	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LPY95_14745	COG2040	homocysteine
LPY95_14750	COG0833	amino acid
LPY95_14755	COG0346	lactoylglutathione lyase activity
LPY95_14760	COG1131	(ABC) transporter
LPY95_14775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPY95_14775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPY95_14785	COG2878	Part of a membrane complex involved in electron transport
LPY95_14800	COG1595	DNA-templated transcription, initiation
LPY95_14825	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LPY95_14840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LPY95_14845	COG0251	oxidation-reduction process
LPY95_14855	COG0392	lysyltransferase activity
LPY95_14855	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LPY95_14890	COG2814	Major facilitator Superfamily
LPY95_14900	COG1902	pentaerythritol trinitrate reductase activity
LPY95_14905	COG2824	Alkylphosphonate utilization operon protein PhnA
LPY95_14915	COG1047	Peptidyl-prolyl cis-trans
LPY95_14920	COG1077	Cell shape determining protein MreB Mrl
LPY95_14935	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LPY95_14945	COG5487	UPF0391 membrane protein
LPY95_14950	COG1451	nucleotide metabolic process
LPY95_14975	COG0183	Belongs to the thiolase family
LPY95_15005	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LPY95_15005	COG1793	dna ligase
LPY95_15015	COG1793	dna ligase
LPY95_15020	COG1201	RNA secondary structure unwinding
LPY95_15030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPY95_15035	COG1278	Cold shock
LPY95_15040	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LPY95_15045	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LPY95_15050	COG1472	Belongs to the glycosyl hydrolase 3 family
LPY95_15055	COG3046	protein related to deoxyribodipyrimidine photolyase
LPY95_15060	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
LPY95_15065	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LPY95_15075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LPY95_15085	COG1381	Involved in DNA repair and RecF pathway recombination
LPY95_15090	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LPY95_15095	COG0571	ribonuclease III activity
LPY95_15110	COG0481	GTPase activity
LPY95_15115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPY95_15130	COG1024	Enoyl-CoA hydratase
LPY95_15130	COG1250	3-hydroxyacyl-CoA dehydrogenase
LPY95_15155	COG1960	acyl-CoA dehydrogenase activity
LPY95_15175	COG3867	Arabinogalactan endo-beta-1,4-galactanase
LPY95_15180	COG3250	beta-galactosidase activity
LPY95_15235	COG3209	COG3209 Rhs family protein
LPY95_15245	COG3209	COG3209 Rhs family protein
LPY95_15255	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LPY95_15265	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LPY95_15285	COG0534	Mate efflux family protein
LPY95_15290	COG0335	large ribosomal subunit rRNA binding
LPY95_15295	COG0336	Belongs to the RNA methyltransferase TrmD family
LPY95_15300	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LPY95_15305	COG0228	four-way junction DNA binding
LPY95_15310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LPY95_15320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LPY95_15325	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LPY95_15360	COG4191	Histidine kinase
LPY95_15360	COG0784	Response regulator, receiver
LPY95_15365	COG4999	Histidine kinase
LPY95_15365	COG3850	Histidine kinase
LPY95_15365	COG3437	response regulator, receiver
LPY95_15365	COG2205	protein histidine kinase activity
LPY95_15370	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LPY95_15385	COG5507	3-demethylubiquinone-9 3-methyltransferase
LPY95_15395	COG4771	TonB-dependent receptor
LPY95_15410	COG2205	protein histidine kinase activity
LPY95_15420	COG2172	sigma factor antagonist activity
LPY95_15425	COG1366	Belongs to the anti-sigma-factor antagonist family
LPY95_15430	COG1366	Belongs to the anti-sigma-factor antagonist family
LPY95_15440	COG0326	Molecular chaperone. Has ATPase activity
LPY95_15445	COG2207	Transcriptional regulator
LPY95_15455	COG3152	Membrane
LPY95_15470	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LPY95_15475	COG1845	cytochrome c oxidase, subunit III
LPY95_15480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LPY95_15515	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LPY95_15515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPY95_15610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LPY95_15615	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LPY95_15620	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LPY95_15625	COG0196	riboflavin kinase activity
LPY95_15630	COG0728	peptidoglycan biosynthetic process
LPY95_15635	COG0268	Binds directly to 16S ribosomal RNA
LPY95_15640	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LPY95_15645	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LPY95_15650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LPY95_15655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LPY95_15660	COG0824	Thioesterase
LPY95_15675	COG1946	Acyl-CoA thioesterase
LPY95_15695	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LPY95_15705	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LPY95_15735	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LPY95_15750	COG2197	response regulator
LPY95_15755	COG4585	Histidine kinase
LPY95_15765	COG0850	regulation of cytokinetic process
LPY95_15770	COG2894	cell division
LPY95_15775	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LPY95_15785	COG0642	Histidine kinase
LPY95_15790	COG0745	RESPONSE REGULATOR receiver
LPY95_15805	COG2194	sulfuric ester hydrolase activity
LPY95_15820	COG2814	Major facilitator Superfamily
LPY95_15825	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPY95_15825	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPY95_15835	COG0656	L-ascorbic acid biosynthetic process
LPY95_15840	COG0753	catalase activity
LPY95_15870	COG1917	Cupin 2, conserved barrel domain protein
LPY95_15870	COG2207	Transcriptional regulator
LPY95_15895	COG1506	peptidase
LPY95_15895	COG0823	Involved in the tonB-independent uptake of proteins
LPY95_15910	COG1297	OPT oligopeptide transporter protein
LPY95_15925	COG0587	DNA-directed DNA polymerase activity
LPY95_15940	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LPY95_15975	COG2080	2 iron, 2 sulfur cluster binding
LPY95_15980	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LPY95_15985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LPY95_16010	COG0492	ferredoxin-NADP+ reductase activity
LPY95_16020	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_16025	COG3537	Alpha-1,2-mannosidase
LPY95_16030	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_16045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LPY95_16055	COG1309	transcriptional regulator
LPY95_16070	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LPY95_16080	COG1196	nuclear chromosome segregation
LPY95_16085	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LPY95_16125	COG1309	transcriptional regulator
LPY95_16130	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_16140	COG0308	aminopeptidase N
LPY95_16145	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LPY95_16155	COG0330	HflC and HflK could
LPY95_16160	COG0330	HflC and HflK could
LPY95_16180	COG0678	peroxiredoxin activity
LPY95_16190	COG4953	penicillin-binding protein 1C
LPY95_16205	COG2373	Large extracellular alpha-helical protein
LPY95_16250	COG3829	transcription factor binding
LPY95_16275	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LPY95_16280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LPY95_16295	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_16310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPY95_16315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LPY95_16320	COG1399	metal-binding, possibly nucleic acid-binding protein
LPY95_16325	COG0424	maF-like protein
LPY95_16345	COG0714	Associated with various cellular activities
LPY95_16365	COG0537	adenosine 5'-monophosphoramidase activity
LPY95_16370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LPY95_16375	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LPY95_16380	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LPY95_16505	COG0314	molybdopterin synthase activity
LPY95_16510	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LPY95_16515	COG0315	cyclic pyranopterin monophosphate synthase activity
LPY95_16525	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LPY95_16530	COG1234	tRNA 3'-trailer cleavage
LPY95_16535	COG3642	lipopolysaccharide core region biosynthetic process
LPY95_16540	COG0859	PFAM glycosyl transferase family 9
LPY95_16555	COG0631	protein serine/threonine phosphatase activity
LPY95_16560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPY95_16565	COG0328	RNA-DNA hybrid ribonuclease activity
LPY95_16575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPY95_16585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LPY95_16615	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LPY95_16625	COG0544	peptidyl-prolyl cis-trans isomerase activity
LPY95_16635	COG3852	Histidine kinase
LPY95_16670	COG0473	3-isopropylmalate dehydrogenase activity
LPY95_16685	COG4783	chaperone-mediated protein folding
LPY95_16700	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LPY95_16710	COG0438	transferase activity, transferring glycosyl groups
LPY95_16715	COG0671	phosphoesterase, PA-phosphatase related
LPY95_16720	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPY95_16730	COG3291	Pkd domain containing protein
LPY95_16765	COG0285	dihydrofolate synthase activity
LPY95_16775	COG0406	alpha-ribazole phosphatase activity
LPY95_16805	COG1063	alcohol dehydrogenase
LPY95_16815	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LPY95_16820	COG4208	sulfate ABC transporter
LPY95_16825	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LPY95_16830	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LPY95_16835	COG0156	8-amino-7-oxononanoate synthase activity
LPY95_16860	COG0604	alcohol dehydrogenase
LPY95_16865	COG0446	pyridine nucleotide-disulphide oxidoreductase
LPY95_16865	COG1902	pentaerythritol trinitrate reductase activity
LPY95_16875	COG0625	glutathione transferase activity
LPY95_16880	COG0039	L-malate dehydrogenase activity
LPY95_16885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LPY95_16890	COG1217	gtp-binding protein TYPA
LPY95_16910	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LPY95_16925	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LPY95_16930	COG0203	ribosomal protein L17
LPY95_16955	COG0201	protein transport
LPY95_16960	COG0200	Binds to the 23S rRNA
LPY95_16965	COG1841	ribosomal large subunit assembly
LPY95_16975	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LPY95_16980	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LPY95_16985	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LPY95_16995	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LPY95_17000	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LPY95_17010	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LPY95_17015	COG0255	Belongs to the universal ribosomal protein uL29 family
LPY95_17020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LPY95_17025	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LPY95_17035	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LPY95_17040	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LPY95_17045	COG0089	rRNA binding
LPY95_17050	COG0088	Forms part of the polypeptide exit tunnel
LPY95_17055	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LPY95_17060	COG0051	transcription antitermination factor activity, RNA binding
LPY95_17065	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LPY95_17070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LPY95_17075	COG0049	tRNA binding
LPY95_17080	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LPY95_17085	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LPY95_17090	COG0085	RNA polymerase activity
LPY95_17095	COG0222	ribosome binding
LPY95_17100	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LPY95_17105	COG0081	regulation of translation
LPY95_17110	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LPY95_17115	COG0250	Participates in transcription elongation, termination and antitermination
LPY95_17130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LPY95_17150	COG0012	GTP binding
LPY95_17155	COG0193	aminoacyl-tRNA hydrolase activity
LPY95_17160	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LPY95_17165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LPY95_17175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LPY95_17180	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LPY95_17190	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LPY95_17195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LPY95_17205	COG0521	Mo-molybdopterin cofactor biosynthetic process
LPY95_17220	COG1254	Belongs to the acylphosphatase family
LPY95_17225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPY95_17230	COG1295	ribonuclease BN
LPY95_17255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LPY95_17260	COG1404	Belongs to the peptidase S8 family
LPY95_17265	COG1404	Belongs to the peptidase S8 family
LPY95_17275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LPY95_17290	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LPY95_17315	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LPY95_17345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPY95_17345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPY95_17365	COG2890	protein-(glutamine-N5) methyltransferase activity
LPY95_17375	COG3634	alkyl hydroperoxide reductase activity
LPY95_17380	COG0583	DNA-binding transcription factor activity
LPY95_17385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPY95_17390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LPY95_17400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPY95_17410	COG2197	response regulator
LPY95_17435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPY95_17445	COG0697	spore germination
LPY95_17480	COG3386	PFAM SMP-30 Gluconolaconase
LPY95_17500	COG1024	Enoyl-CoA hydratase
LPY95_17510	COG0318	PFAM AMP-dependent synthetase and ligase
LPY95_17515	COG0583	DNA-binding transcription factor activity
LPY95_17520	COG3384	dioxygenase
LPY95_17550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPY95_17555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPY95_17570	COG2096	Adenosyltransferase
LPY95_17575	COG0123	including yeast histone deacetylase and acetoin utilization protein
LPY95_17590	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LPY95_17595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LPY95_17600	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LPY95_17605	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LPY95_17610	COG2967	ApaG domain
LPY95_17615	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LPY95_17635	COG0747	negative chemotaxis
LPY95_17665	COG0431	NADPH-dependent FMN reductase
LPY95_17670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LPY95_17680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LPY95_17685	COG1116	anion transmembrane transporter activity
LPY95_17695	COG3829	transcription factor binding
LPY95_17710	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LPY95_17715	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LPY95_17735	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LPY95_17745	COG0642	Histidine kinase
LPY95_17760	COG4181	ATPase activity
LPY95_17770	COG2175	clavaminate synthase activity
LPY95_17780	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LPY95_17785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LPY95_17805	COG4771	TonB-dependent receptor
LPY95_17820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LPY95_17825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LPY95_17845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPY95_17850	COG4106	trans-aconitate 2-methyltransferase activity
LPY95_17900	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LPY95_17910	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LPY95_17915	COG2226	methyltransferase
LPY95_17940	COG0366	Alpha amylase catalytic
LPY95_17965	COG3321	synthase
LPY95_17965	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_17965	COG0604	alcohol dehydrogenase
LPY95_17975	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LPY95_17985	COG0494	nUDIX hydrolase
LPY95_17990	COG0653	protein targeting
LPY95_17995	COG0739	heme binding
LPY95_17995	COG1196	nuclear chromosome segregation
LPY95_17995	COG0741	lytic transglycosylase activity
LPY95_18005	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LPY95_18020	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LPY95_18025	COG1181	Belongs to the D-alanine--D-alanine ligase family
LPY95_18030	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPY95_18035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LPY95_18045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPY95_18050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LPY95_18055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LPY95_18065	COG3116	cell division
LPY95_18070	COG0275	rRNA processing
LPY95_18115	COG0792	nuclease activity
LPY95_18120	COG1988	membrane-bound metal-dependent
LPY95_18125	COG0277	FAD linked oxidase domain protein
LPY95_18135	COG0745	RESPONSE REGULATOR receiver
LPY95_18155	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LPY95_18160	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LPY95_18165	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LPY95_18185	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LPY95_18190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LPY95_18195	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LPY95_18220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPY95_18220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPY95_18230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LPY95_18235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LPY95_18245	COG0488	(ABC) transporter
LPY95_18255	COG0697	spore germination
LPY95_18265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LPY95_18280	COG3791	Glutathione-dependent formaldehyde-activating
LPY95_18310	COG2205	protein histidine kinase activity
LPY95_18325	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LPY95_18330	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LPY95_18345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LPY95_18360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LPY95_18365	COG1012	belongs to the aldehyde dehydrogenase family
LPY95_18370	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LPY95_18375	COG0617	tRNA 3'-terminal CCA addition
LPY95_18385	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LPY95_18390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPY95_18395	COG1609	Transcriptional regulator
LPY95_18405	COG2188	Transcriptional regulator
LPY95_18420	COG3250	beta-galactosidase activity
LPY95_18450	COG4795	General secretion pathway protein
LPY95_18470	COG1459	type II secretion system
LPY95_18525	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LPY95_18530	COG4191	Histidine kinase
LPY95_18535	COG0784	Response regulator, receiver
LPY95_18540	COG4251	negative regulation of phosphorylation
LPY95_18545	COG2823	Periplasmic or secreted lipoprotein
LPY95_18550	COG0673	inositol 2-dehydrogenase activity
LPY95_18555	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LPY95_18590	COG1051	belongs to the nudix hydrolase family
LPY95_18590	COG1056	cytidyltransferase-related domain
LPY95_18600	COG0583	DNA-binding transcription factor activity
LPY95_18615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LPY95_18620	COG0321	lipoyl(octanoyl) transferase activity
LPY95_18625	COG2921	Belongs to the UPF0250 family
LPY95_18635	COG1686	Belongs to the peptidase S11 family
LPY95_18640	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LPY95_18645	COG2951	lytic endotransglycosylase activity
LPY95_18655	COG0772	Belongs to the SEDS family
LPY95_18670	COG1792	Involved in formation and maintenance of cell shape
LPY95_18675	COG1077	Cell shape determining protein MreB Mrl
LPY95_18680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LPY95_18685	COG3284	Transcriptional regulator
LPY95_18695	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LPY95_18730	COG0308	aminopeptidase N
LPY95_18735	COG3300	MHYT domain
LPY95_18735	COG5001	Diguanylate cyclase
LPY95_18740	COG2226	methyltransferase
LPY95_18765	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LPY95_18770	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LPY95_18775	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LPY95_18785	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LPY95_18795	COG2832	Protein of unknown function (DUF454)
LPY95_18805	COG0436	Aminotransferase
LPY95_18815	COG1505	serine-type exopeptidase activity
LPY95_18840	COG0181	hydroxymethylbilane synthase activity
LPY95_18850	COG3275	phosphorelay sensor kinase activity
LPY95_18860	COG2943	transferase activity, transferring hexosyl groups
LPY95_18880	COG0659	secondary active sulfate transmembrane transporter activity
LPY95_18885	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPY95_18885	COG5297	Belongs to the glycosyl hydrolase family 6
LPY95_18890	COG0840	transmembrane signaling receptor activity
LPY95_18895	COG5001	Diguanylate cyclase
LPY95_18935	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
LPY95_18955	COG1113	amino acid transport
LPY95_18970	COG0697	spore germination
LPY95_19005	COG0823	Involved in the tonB-independent uptake of proteins
LPY95_19005	COG1506	peptidase
LPY95_19015	COG2409	Drug exporters of the RND superfamily
LPY95_19040	COG0435	Glutathione S-transferase
LPY95_19050	COG4221	oxidoreductase activity
LPY95_19065	COG4221	oxidoreductase activity
LPY95_19110	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LPY95_19150	COG0546	phosphoglycolate phosphatase activity
LPY95_19155	COG1802	Transcriptional regulator
LPY95_19165	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LPY95_19195	COG3052	prosthetic group binding
LPY95_19220	COG2353	YceI-like domain
LPY95_19225	COG0778	Nitroreductase
LPY95_19240	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LPY95_19245	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LPY95_19255	COG3386	PFAM SMP-30 Gluconolaconase
LPY95_19270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LPY95_19290	COG0459	protein refolding
LPY95_19305	COG2356	endonuclease I
LPY95_19310	COG0300	oxidoreductase activity
LPY95_19335	COG1324	tolerance protein
LPY95_19345	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LPY95_19350	COG0511	ligase activity, forming carbon-carbon bonds
LPY95_19360	COG0439	Biotin carboxylase
LPY95_19385	COG2264	protein methyltransferase activity
LPY95_19405	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LPY95_19410	COG4589	Belongs to the CDS family
LPY95_19435	COG0671	phosphoesterase, PA-phosphatase related
LPY95_19435	COG2453	phosphatase
LPY95_19440	COG2267	carboxylic ester hydrolase activity
LPY95_19445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LPY95_19450	COG0138	bifunctional purine biosynthesis protein purh
LPY95_19460	COG0151	Belongs to the GarS family
LPY95_19470	COG1289	transmembrane transporter activity
LPY95_19475	COG2814	Major facilitator Superfamily
LPY95_19485	COG2814	Major facilitator Superfamily
LPY95_19500	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LPY95_19515	COG0316	Belongs to the HesB IscA family
LPY95_19555	COG1051	belongs to the nudix hydrolase family
LPY95_19570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LPY95_19580	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LPY95_19590	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LPY95_19595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LPY95_19605	COG0134	indole-3-glycerol-phosphate synthase activity
LPY95_19610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LPY95_19635	COG1597	lipid kinase activity
LPY95_19640	COG0456	acetyltransferase
LPY95_19655	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LPY95_19660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LPY95_19680	COG3179	chitinase
LPY95_19700	COG2111	Na H antiporter
LPY95_19700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LPY95_19705	COG1006	Multisubunit Na H antiporter MnhC subunit
LPY95_19710	COG0651	ATP synthesis coupled electron transport
LPY95_19720	COG2212	antiporter activity
LPY95_19725	COG1320	monovalent cation:proton antiporter activity
LPY95_19745	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LPY95_19750	COG2852	Protein conserved in bacteria
LPY95_19770	COG3104	oligopeptide transport
LPY95_19775	COG3483	tryptophan 2,3-dioxygenase activity
LPY95_19785	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LPY95_19800	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPY95_19810	COG0513	Belongs to the DEAD box helicase family
LPY95_19820	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_19825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPY95_19855	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_19860	COG0702	epimerase
LPY95_19890	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LPY95_19895	COG0297	glycogen (starch) synthase activity
LPY95_19905	COG2354	Protein conserved in bacteria
LPY95_19910	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LPY95_19915	COG1368	sulfuric ester hydrolase activity
LPY95_19920	COG3264	Mechanosensitive ion channel
LPY95_19920	COG1511	domain protein
LPY95_19995	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LPY95_20070	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LPY95_20080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LPY95_20085	COG0156	8-amino-7-oxononanoate synthase activity
LPY95_20095	COG2267	carboxylic ester hydrolase activity
LPY95_20100	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_20125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LPY95_20135	COG0445	tRNA wobble uridine modification
LPY95_20155	COG1414	Transcriptional regulator
LPY95_20165	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LPY95_20170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPY95_20180	COG3485	protocatechuate 3,4-dioxygenase
LPY95_20195	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LPY95_20200	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LPY95_20225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LPY95_20230	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LPY95_20290	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LPY95_20305	COG0129	dihydroxy-acid dehydratase activity
LPY95_20355	COG1733	regulation of RNA biosynthetic process
LPY95_20360	COG0702	epimerase
LPY95_20390	COG0583	DNA-binding transcription factor activity
LPY95_20395	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LPY95_20420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPY95_20425	COG2205	protein histidine kinase activity
LPY95_20430	COG0745	RESPONSE REGULATOR receiver
LPY95_20450	COG1902	pentaerythritol trinitrate reductase activity
LPY95_20455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LPY95_20470	COG2814	Major facilitator Superfamily
LPY95_20500	COG0084	hydrolase, TatD family'
LPY95_20520	COG2252	PERMEase
LPY95_20530	COG1957	nucleoside hydrolase
LPY95_20565	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LPY95_20585	COG2072	flavoprotein involved in K transport
LPY95_20590	COG2351	hydroxyisourate hydrolase activity
LPY95_20595	COG4807	Protein conserved in bacteria
LPY95_20600	COG1643	Atp-dependent helicase
LPY95_20615	COG1187	pseudouridine synthase activity
LPY95_20630	COG2130	NADP-dependent
LPY95_20660	COG1764	response to oxidative stress
LPY95_20665	COG1846	Transcriptional regulator
LPY95_20670	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LPY95_20680	COG0697	spore germination
LPY95_20750	COG1960	acyl-CoA dehydrogenase activity
LPY95_20755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LPY95_20760	COG4770	biotin carboxylase activity
LPY95_20790	COG2224	Isocitrate lyase
LPY95_20795	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LPY95_20800	COG0583	DNA-binding transcription factor activity
LPY95_20805	COG0475	glutathione-regulated potassium exporter activity
LPY95_20835	COG0339	signal peptide processing
LPY95_20840	COG1446	asparaginase
LPY95_20860	COG0564	pseudouridine synthase activity
LPY95_20870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LPY95_20880	COG1181	Belongs to the D-alanine--D-alanine ligase family
LPY95_20895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPY95_20905	COG0318	PFAM AMP-dependent synthetase and ligase
LPY95_20910	COG0727	PFAM Uncharacterised protein family (UPF0153)
LPY95_20915	COG0596	Alpha beta hydrolase
LPY95_20925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPY95_20940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LPY95_20965	COG2205	protein histidine kinase activity
LPY95_20970	COG0028	Belongs to the TPP enzyme family
LPY95_20985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LPY95_20990	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LPY95_20995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPY95_21030	COG0183	Belongs to the thiolase family
LPY95_21055	COG2032	superoxide dismutase activity
LPY95_21060	COG2032	superoxide dismutase activity
LPY95_21065	COG2204	response regulator
LPY95_21070	COG3852	Histidine kinase
LPY95_21075	COG0004	ammonium transporteR
LPY95_21080	COG0347	Belongs to the P(II) protein family
LPY95_21085	COG0174	glutamine synthetase
LPY95_21090	COG1968	undecaprenyl-diphosphatase activity
LPY95_21100	COG1881	PFAM PEBP family protein
LPY95_21130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPY95_21140	COG2062	phosphohistidine phosphatase, SixA
LPY95_21145	COG0489	protein tyrosine kinase activity
LPY95_21165	COG1396	sequence-specific DNA binding
LPY95_21185	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LPY95_21200	COG1125	glycine betaine transport
LPY95_21215	COG1119	ATPase activity
LPY95_21225	COG1752	Esterase of the alpha-beta hydrolase superfamily
LPY95_21235	COG1522	sequence-specific DNA binding
LPY95_21240	COG3186	Phenylalanine-4-hydroxylase
LPY95_21255	COG2755	lipolytic protein G-D-S-L family
LPY95_21265	COG1028	Short-chain dehydrogenase reductase Sdr
LPY95_21270	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
LPY95_21275	COG1609	Transcriptional regulator
LPY95_21280	COG3507	Belongs to the glycosyl hydrolase 43 family
LPY95_21295	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LPY95_21350	COG2911	Protein conserved in bacteria
LPY95_21355	COG0729	surface antigen
LPY95_21360	COG4771	TonB-dependent receptor
LPY95_21365	COG0457	Tetratricopeptide repeat
LPY95_21375	COG0752	glycyl-tRNA synthetase alpha subunit
LPY95_21380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LPY95_21390	COG0519	Catalyzes the synthesis of GMP from XMP
LPY95_21390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LPY95_21400	COG0805	protein transport
LPY95_21405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LPY95_21410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LPY95_21420	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LPY95_21435	COG2974	May be involved in recombination
LPY95_21440	COG0037	tRNA processing
LPY95_21445	COG2115	Belongs to the xylose isomerase family
LPY95_21455	COG3661	Belongs to the glycosyl hydrolase 67 family
LPY95_21465	COG4948	Mandelate Racemase Muconate Lactonizing
LPY95_21475	COG1472	Belongs to the glycosyl hydrolase 3 family
LPY95_21480	COG0246	Mannitol dehydrogenase
LPY95_21530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LPY95_21555	COG3386	PFAM SMP-30 Gluconolaconase
LPY95_21565	COG3250	beta-galactosidase activity
LPY95_21570	COG1904	glucuronate isomerase
LPY95_21590	COG3693	PFAM glycoside hydrolase, family 10
LPY95_21605	COG2211	Major facilitator Superfamily
LPY95_21680	COG2937	Belongs to the GPAT DAPAT family
LPY95_21710	COG0284	orotidine-5'-phosphate decarboxylase activity
LPY95_21715	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
LPY95_21720	COG3132	Protein of unknown function, DUF480
LPY95_21735	COG0210	DNA helicase
LPY95_21740	COG1435	thymidine kinase activity
LPY95_21750	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LPY95_21760	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LPY95_21790	COG3135	benzoate transporter
LPY95_21810	COG0676	glucose-6-phosphate 1-epimerase activity
LPY95_21820	COG3012	SEC-C Motif Domain Protein
LPY95_21825	COG0730	response to heat
LPY95_21845	COG0302	gtp cyclohydrolase
LPY95_21860	COG1566	PFAM secretion protein HlyD family protein
LPY95_21870	COG1289	transmembrane transporter activity
LPY95_21875	COG0477	Major facilitator Superfamily
LPY95_21885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPY95_21905	COG4691	Plasmid stability protein
LPY95_21920	COG1487	ribonuclease activity
LPY95_21950	COG0564	pseudouridine synthase activity
LPY95_21960	COG0439	Biotin carboxylase
LPY95_22000	COG1074	ATP-dependent DNA helicase activity
LPY95_22020	COG1127	ABC transporter
LPY95_22025	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPY95_22030	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LPY95_22045	COG2853	Lipoprotein
LPY95_22055	COG0386	Belongs to the glutathione peroxidase family
LPY95_22065	COG1322	Protein conserved in bacteria
LPY95_22070	COG0604	alcohol dehydrogenase
LPY95_22075	COG0583	DNA-binding transcription factor activity
LPY95_22085	COG0625	glutathione transferase activity
LPY95_22095	COG0531	amino acid
LPY95_22100	COG3537	Alpha-1,2-mannosidase
LPY95_22110	COG3706	GGDEF domain
LPY95_22140	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LPY95_22145	COG0861	Integral membrane protein TerC family
LPY95_22155	COG0584	glycerophosphoryl diester phosphodiesterase
LPY95_22170	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LPY95_22175	COG0726	polysaccharide deacetylase
LPY95_22180	COG0706	membrane insertase activity
LPY95_22185	COG0594	ribonuclease P activity
LPY95_22240	COG1192	Involved in chromosome partitioning
LPY95_22365	COG1192	Involved in chromosome partitioning
LPY95_22465	COG1192	Involved in chromosome partitioning
LPY95_22490	COG4644	lycopene metabolic process
LPY95_22525	COG4456	Virulence-associated protein
LPY95_22545	COG2951	lytic endotransglycosylase activity
LPY95_22560	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LPY95_22580	COG3012	SEC-C Motif Domain Protein
LPY95_22580	COG3318	Belongs to the UPF0149 family