locus-tag	class	description
GH913_00020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GH913_00025	COG0473	3-isopropylmalate dehydrogenase activity
GH913_00030	COG0066	3-isopropylmalate dehydratase activity
GH913_00035	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GH913_00055	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GH913_00060	COG1538	Outer membrane efflux protein
GH913_00065	COG1519	Transferase
GH913_00070	COG1560	Kdo2-lipid A biosynthetic process
GH913_00095	COG0280	phosphate acetyltransferase
GH913_00095	COG0281	malic enzyme
GH913_00100	COG1301	dicarboxylic acid transport
GH913_00125	COG0583	DNA-binding transcription factor activity
GH913_00130	COG0667	Aldo Keto reductase
GH913_00145	COG2197	response regulator
GH913_00150	COG1840	ABC-type Fe3 transport system, periplasmic component
GH913_00155	COG0642	Histidine kinase
GH913_00170	COG2851	Citrate transporter
GH913_00175	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_00180	COG1609	Transcriptional regulator
GH913_00185	COG2211	Major facilitator Superfamily
GH913_00210	COG1162	GTPase activity
GH913_00275	COG4773	Receptor
GH913_00280	COG0726	polysaccharide deacetylase
GH913_00285	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GH913_00300	COG3964	amidohydrolase
GH913_00305	COG0402	S-adenosylhomocysteine deaminase activity
GH913_00325	COG1307	EDD domain protein, DegV family
GH913_00330	COG0242	peptide deformylase activity
GH913_00350	COG0457	Tetratricopeptide repeat
GH913_00355	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GH913_00360	COG1215	transferase activity, transferring glycosyl groups
GH913_00365	COG1215	transferase activity, transferring glycosyl groups
GH913_00380	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GH913_00425	COG2188	Transcriptional regulator
GH913_00440	COG1450	Type ii and iii secretion system protein
GH913_00455	COG3166	PFAM Fimbrial assembly family protein
GH913_00460	COG3156	type II secretion system protein K
GH913_00465	COG4795	General secretion pathway protein
GH913_00470	COG2165	general secretion pathway protein
GH913_00475	COG4970	Tfp pilus assembly protein FimT
GH913_00480	COG2165	general secretion pathway protein
GH913_00485	COG1459	type II secretion system
GH913_00490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GH913_00495	COG1404	Belongs to the peptidase S8 family
GH913_00500	COG5295	Hep Hag repeat protein
GH913_00510	COG1404	Belongs to the peptidase S8 family
GH913_00520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GH913_00520	COG0047	phosphoribosylformylglycinamidine synthase activity
GH913_00525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GH913_00530	COG4974	Belongs to the 'phage' integrase family
GH913_00545	COG0795	lipopolysaccharide-transporting ATPase activity
GH913_00555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GH913_00570	COG0525	valine-tRNA ligase activity
GH913_00600	COG1183	phosphatidylcholine synthase activity
GH913_00610	COG0442	prolyl-tRNA aminoacylation
GH913_00625	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GH913_00630	COG1127	ABC transporter
GH913_00635	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GH913_00635	COG3218	ABC-type transport auxiliary lipoprotein component
GH913_00665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GH913_00670	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GH913_00670	COG0662	Cupin 2, conserved barrel domain protein
GH913_00700	COG2086	electron transfer activity
GH913_00715	COG0463	Glycosyl transferase, family 2
GH913_00750	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GH913_00755	COG0438	transferase activity, transferring glycosyl groups
GH913_00775	COG0438	transferase activity, transferring glycosyl groups
GH913_00780	COG0626	cystathionine gamma-synthase activity
GH913_00810	COG0625	glutathione transferase activity
GH913_00825	COG0513	Belongs to the DEAD box helicase family
GH913_00835	COG4206	TonB-dependent receptor
GH913_00840	COG0720	synthase
GH913_00850	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GH913_00855	COG1956	GAF domain-containing protein
GH913_00865	COG2819	hydrolase of the alpha beta superfamily
GH913_00880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GH913_00885	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GH913_00900	COG0339	signal peptide processing
GH913_00955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GH913_00960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH913_00965	COG4591	ABC-type transport system involved in lipoprotein release permease component
GH913_00965	COG1136	(ABC) transporter
GH913_00970	COG0577	efflux transmembrane transporter activity
GH913_00975	COG0577	efflux transmembrane transporter activity
GH913_00985	COG2204	response regulator
GH913_00990	COG4191	Histidine kinase
GH913_00995	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GH913_01010	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GH913_01015	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GH913_01020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GH913_01025	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GH913_01030	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GH913_01035	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GH913_01045	COG0356	it plays a direct role in the translocation of protons across the membrane
GH913_01065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GH913_01075	COG0508	dehydrogenase complex catalyzes the overall conversion of
GH913_01125	COG2011	ABC-type metal ion transport system permease component
GH913_01130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GH913_01135	COG0697	spore germination
GH913_01140	COG1666	GTP binding
GH913_01150	COG0784	Response regulator, receiver
GH913_01150	COG5002	protein histidine kinase activity
GH913_01150	COG2198	Histidine kinase
GH913_01170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GH913_01175	COG1187	pseudouridine synthase activity
GH913_01200	COG2205	protein histidine kinase activity
GH913_01200	COG2202	Pas domain
GH913_01220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GH913_01225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH913_01230	COG1522	sequence-specific DNA binding
GH913_01280	COG0842	Transport permease protein
GH913_01285	COG1131	(ABC) transporter
GH913_01290	COG0025	NhaP-type Na H and K H
GH913_01295	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GH913_01300	COG1573	uracil-dna glycosylase
GH913_01310	COG3384	dioxygenase
GH913_01320	COG0583	DNA-binding transcription factor activity
GH913_01330	COG0667	Aldo Keto reductase
GH913_01340	COG3590	peptidase
GH913_01360	COG0531	amino acid
GH913_01375	COG2972	Histidine kinase
GH913_01395	COG3685	Protein conserved in bacteria
GH913_01400	COG3546	catalase activity
GH913_01440	COG1271	oxidase subunit
GH913_01445	COG1294	oxidase, subunit
GH913_01460	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_01465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GH913_01485	COG1132	(ABC) transporter
GH913_01500	COG1063	alcohol dehydrogenase
GH913_01590	COG0583	DNA-binding transcription factor activity
GH913_01595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GH913_01640	COG0024	Methionine aminopeptidase
GH913_01665	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GH913_01700	COG0582	viral genome integration into host DNA
GH913_01715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GH913_01720	COG1490	D-aminoacyl-tRNA deacylase activity
GH913_01725	COG1560	Kdo2-lipid A biosynthetic process
GH913_01780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GH913_01780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GH913_01785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GH913_01790	COG0242	peptide deformylase activity
GH913_01795	COG1652	LysM domain
GH913_01800	COG0758	DNA mediated transformation
GH913_01820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GH913_01820	COG1754	DNA topoisomerase type I activity
GH913_01825	COG0009	L-threonylcarbamoyladenylate synthase
GH913_01840	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_01850	COG0616	signal peptide processing
GH913_01855	COG0534	Mate efflux family protein
GH913_01875	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GH913_01880	COG0625	glutathione transferase activity
GH913_01895	COG1252	NADH dehydrogenase
GH913_01900	COG2860	membrane
GH913_01905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GH913_01910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GH913_01915	COG3437	response regulator, receiver
GH913_01920	COG2177	Part of the ABC transporter FtsEX involved in
GH913_01925	COG2884	Cell division ATP-binding protein ftsE
GH913_01935	COG3118	belongs to the thioredoxin family
GH913_01940	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GH913_01945	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GH913_01950	COG0583	DNA-binding transcription factor activity
GH913_01975	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GH913_01975	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GH913_01980	COG1473	amidohydrolase
GH913_01985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH913_01990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GH913_02000	COG5383	Protein conserved in bacteria
GH913_02040	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GH913_02045	COG3023	N-Acetylmuramoyl-L-alanine amidase
GH913_02055	COG4948	Mandelate Racemase Muconate Lactonizing
GH913_02065	COG0531	amino acid
GH913_02080	COG4682	membrane
GH913_02085	COG2133	pyrroloquinoline quinone binding
GH913_02095	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GH913_02100	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GH913_02105	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GH913_02110	COG1610	YqeY-like protein
GH913_02115	COG1295	ribonuclease BN
GH913_02120	COG0358	DNA primase activity
GH913_02135	COG0109	protoheme IX farnesyltransferase activity
GH913_02165	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GH913_02180	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GH913_02220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GH913_02225	COG0739	heme binding
GH913_02230	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GH913_02240	COG2211	Major facilitator Superfamily
GH913_02245	COG0708	Exodeoxyribonuclease III
GH913_02250	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GH913_02260	COG1192	Involved in chromosome partitioning
GH913_02265	COG1475	DNA binding
GH913_02280	COG0463	Glycosyl transferase, family 2
GH913_02300	COG0756	dUTP diphosphatase activity
GH913_02305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GH913_02310	COG2003	Belongs to the UPF0758 family
GH913_02315	COG0018	arginyl-trna synthetase
GH913_02330	COG4221	oxidoreductase activity
GH913_02345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GH913_02350	COG1166	arginine decarboxylase activity
GH913_02355	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GH913_02390	COG0606	chelatase, subunit chli
GH913_02405	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GH913_02430	COG1690	Belongs to the RtcB family
GH913_02465	COG1090	epimerase
GH913_02470	COG0745	RESPONSE REGULATOR receiver
GH913_02475	COG0642	Histidine kinase
GH913_02500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GH913_02525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GH913_02530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GH913_02545	COG0753	catalase activity
GH913_02560	COG2197	response regulator
GH913_02565	COG4585	Histidine kinase
GH913_02570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH913_02575	COG1136	(ABC) transporter
GH913_02600	COG0697	spore germination
GH913_02615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH913_02620	COG0180	Tryptophanyl-tRNA synthetase
GH913_02625	COG3237	CsbD-like
GH913_02665	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GH913_02695	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GH913_02700	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GH913_02700	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GH913_02725	COG2205	protein histidine kinase activity
GH913_02730	COG0745	RESPONSE REGULATOR receiver
GH913_02740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GH913_02760	COG1199	ATP-dependent helicase activity
GH913_02775	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GH913_02850	COG0625	glutathione transferase activity
GH913_02885	COG4555	ABC transporter
GH913_02895	COG1476	TRANSCRIPTIONal
GH913_02940	COG0543	2 iron, 2 sulfur cluster binding
GH913_02940	COG0633	Ferredoxin
GH913_02945	COG1131	(ABC) transporter
GH913_02950	COG0842	Transport permease protein
GH913_02960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GH913_02995	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GH913_03000	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GH913_03010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GH913_03010	COG1042	CoA-binding domain protein
GH913_03010	COG0045	succinate-CoA ligase (ADP-forming) activity
GH913_03015	COG2239	Acts as a magnesium transporter
GH913_03030	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GH913_03035	COG3387	PFAM Glycoside hydrolase 15-related
GH913_03050	COG3100	YcgL domain-containing protein
GH913_03055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GH913_03065	COG0463	Glycosyl transferase, family 2
GH913_03085	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_03125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GH913_03140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GH913_03160	COG1506	peptidase
GH913_03160	COG0823	Involved in the tonB-independent uptake of proteins
GH913_03160	COG4946	Tricorn protease homolog
GH913_03175	COG0408	coproporphyrinogen oxidase activity
GH913_03210	COG2815	serine threonine protein kinase
GH913_03210	COG0515	serine threonine protein kinase
GH913_03215	COG0631	protein serine/threonine phosphatase activity
GH913_03250	COG3501	Rhs element vgr protein
GH913_03390	COG0210	DNA helicase
GH913_03400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GH913_03405	COG0583	DNA-binding transcription factor activity
GH913_03410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GH913_03420	COG2159	amidohydrolase
GH913_03425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GH913_03430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GH913_03445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH913_03465	COG0357	Ribosomal RNA small subunit methyltransferase G
GH913_03470	COG3540	Alkaline phosphatase
GH913_03480	COG2091	lysine biosynthetic process via aminoadipic acid
GH913_03495	COG0708	Exodeoxyribonuclease III
GH913_03500	COG1940	carbohydrate kinase activity
GH913_03500	COG1846	Transcriptional regulator
GH913_03510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GH913_03520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GH913_03525	COG3162	membrane
GH913_03535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GH913_03580	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_03585	COG0179	Fumarylacetoacetate (FAA) hydrolase
GH913_03590	COG4948	Mandelate Racemase Muconate Lactonizing
GH913_03595	COG3254	rhamnose metabolic process
GH913_03600	COG0738	Major facilitator superfamily
GH913_03605	COG1414	Transcriptional regulator
GH913_03615	COG1971	Probably functions as a manganese efflux pump
GH913_03620	COG2205	protein histidine kinase activity
GH913_03630	COG3459	Glycosyltransferase 36 associated
GH913_03635	COG2211	Major facilitator Superfamily
GH913_03640	COG3265	gluconokinase activity
GH913_03645	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GH913_03675	COG1192	Involved in chromosome partitioning
GH913_03700	COG3077	Addiction module antitoxin, RelB DinJ family
GH913_03705	COG3041	Addiction module toxin RelE StbE family
GH913_03785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GH913_03805	COG2948	multi-organism process
GH913_03810	COG3504	Conjugal transfer protein
GH913_03970	COG2948	multi-organism process
GH913_03975	COG3504	Conjugal transfer protein
GH913_03985	COG3704	protein secretion by the type IV secretion system
GH913_04090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GH913_04135	COG0714	Associated with various cellular activities
GH913_04165	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GH913_04175	COG4772	TonB-dependent receptor
GH913_04185	COG0662	Cupin 2, conserved barrel domain protein
GH913_04235	COG1304	FMN binding
GH913_04245	COG4585	Histidine kinase
GH913_04250	COG2197	response regulator
GH913_04270	COG3710	Transcriptional regulator
GH913_04275	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GH913_04330	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_04335	COG0300	oxidoreductase activity
GH913_04355	COG1272	protein, Hemolysin III
GH913_04360	COG1111	helicase
GH913_04360	COG1205	dead DEAH box helicase
GH913_04445	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GH913_04470	COG1132	(ABC) transporter
GH913_04500	COG0367	asparagine synthase
GH913_04520	COG0438	transferase activity, transferring glycosyl groups
GH913_04520	COG0297	glycogen (starch) synthase activity
GH913_04525	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GH913_04540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GH913_04585	COG0067	glutamate synthase
GH913_04585	COG0069	glutamate synthase activity
GH913_04585	COG0070	glutamate synthase
GH913_04590	COG0493	'glutamate synthase
GH913_04605	COG1064	alcohol dehydrogenase
GH913_04610	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GH913_04615	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GH913_04625	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GH913_04635	COG2234	aminopeptidase activity
GH913_04645	COG4942	peptidase
GH913_04650	COG0793	Belongs to the peptidase S41A family
GH913_04735	COG2003	Belongs to the UPF0758 family
GH913_04770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GH913_04780	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GH913_04810	COG0501	Belongs to the peptidase M48B family
GH913_04820	COG0187	DNA topoisomerase II activity
GH913_04825	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GH913_04835	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GH913_04840	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GH913_04845	COG0594	ribonuclease P activity
GH913_04850	COG0706	membrane insertase activity
GH913_04855	COG0726	polysaccharide deacetylase
GH913_04860	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GH913_04875	COG0584	glycerophosphoryl diester phosphodiesterase
GH913_04885	COG0861	Integral membrane protein TerC family
GH913_04890	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GH913_04915	COG3706	GGDEF domain
GH913_04925	COG3537	Alpha-1,2-mannosidase
GH913_04930	COG0531	amino acid
GH913_04940	COG0625	glutathione transferase activity
GH913_04950	COG0583	DNA-binding transcription factor activity
GH913_04955	COG0604	alcohol dehydrogenase
GH913_04960	COG1322	Protein conserved in bacteria
GH913_04970	COG0386	Belongs to the glutathione peroxidase family
GH913_04980	COG2853	Lipoprotein
GH913_04995	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GH913_05000	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GH913_05005	COG1127	ABC transporter
GH913_05020	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GH913_05025	COG1074	ATP-dependent DNA helicase activity
GH913_05065	COG0439	Biotin carboxylase
GH913_05120	COG4691	Plasmid stability protein
GH913_05140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GH913_05150	COG0477	Major facilitator Superfamily
GH913_05155	COG1289	transmembrane transporter activity
GH913_05165	COG1566	PFAM secretion protein HlyD family protein
GH913_05180	COG0302	gtp cyclohydrolase
GH913_05200	COG0730	response to heat
GH913_05205	COG3012	SEC-C Motif Domain Protein
GH913_05215	COG0676	glucose-6-phosphate 1-epimerase activity
GH913_05235	COG3135	benzoate transporter
GH913_05265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GH913_05275	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GH913_05285	COG1435	thymidine kinase activity
GH913_05290	COG0210	DNA helicase
GH913_05305	COG3132	Protein of unknown function, DUF480
GH913_05310	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
GH913_05315	COG0284	orotidine-5'-phosphate decarboxylase activity
GH913_05345	COG2937	Belongs to the GPAT DAPAT family
GH913_05425	COG2211	Major facilitator Superfamily
GH913_05440	COG3693	PFAM glycoside hydrolase, family 10
GH913_05455	COG1904	glucuronate isomerase
GH913_05460	COG3250	beta-galactosidase activity
GH913_05470	COG3386	PFAM SMP-30 Gluconolaconase
GH913_05495	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GH913_05545	COG0246	Mannitol dehydrogenase
GH913_05550	COG1472	Belongs to the glycosyl hydrolase 3 family
GH913_05560	COG4948	Mandelate Racemase Muconate Lactonizing
GH913_05570	COG3661	Belongs to the glycosyl hydrolase 67 family
GH913_05580	COG2115	Belongs to the xylose isomerase family
GH913_05585	COG0037	tRNA processing
GH913_05590	COG2974	May be involved in recombination
GH913_05605	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GH913_05615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GH913_05620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GH913_05625	COG0805	protein transport
GH913_05635	COG0519	Catalyzes the synthesis of GMP from XMP
GH913_05635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GH913_05645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GH913_05650	COG0752	glycyl-tRNA synthetase alpha subunit
GH913_05660	COG0457	Tetratricopeptide repeat
GH913_05665	COG4771	TonB-dependent receptor
GH913_05670	COG0729	surface antigen
GH913_05675	COG2911	Protein conserved in bacteria
GH913_05720	COG2755	lipolytic protein G-D-S-L family
GH913_05720	COG0657	acetylesterase activity
GH913_05730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH913_05745	COG3507	Belongs to the glycosyl hydrolase 43 family
GH913_05750	COG1609	Transcriptional regulator
GH913_05755	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GH913_05760	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_05770	COG2755	lipolytic protein G-D-S-L family
GH913_05785	COG3186	Phenylalanine-4-hydroxylase
GH913_05790	COG1522	sequence-specific DNA binding
GH913_05800	COG1752	Esterase of the alpha-beta hydrolase superfamily
GH913_05810	COG1119	ATPase activity
GH913_05825	COG1125	glycine betaine transport
GH913_05840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GH913_05860	COG1396	sequence-specific DNA binding
GH913_05880	COG0489	protein tyrosine kinase activity
GH913_05885	COG2062	phosphohistidine phosphatase, SixA
GH913_05895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GH913_05925	COG1881	PFAM PEBP family protein
GH913_05935	COG1968	undecaprenyl-diphosphatase activity
GH913_05940	COG0174	glutamine synthetase
GH913_05945	COG0347	Belongs to the P(II) protein family
GH913_05950	COG0004	ammonium transporteR
GH913_05955	COG3852	Histidine kinase
GH913_05960	COG2204	response regulator
GH913_05965	COG2032	superoxide dismutase activity
GH913_05970	COG2032	superoxide dismutase activity
GH913_05985	COG0183	Belongs to the thiolase family
GH913_06020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GH913_06025	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GH913_06030	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GH913_06045	COG0028	Belongs to the TPP enzyme family
GH913_06050	COG2205	protein histidine kinase activity
GH913_06075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GH913_06090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GH913_06100	COG0596	Alpha beta hydrolase
GH913_06110	COG0318	PFAM AMP-dependent synthetase and ligase
GH913_06120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GH913_06130	COG1181	Belongs to the D-alanine--D-alanine ligase family
GH913_06140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GH913_06150	COG0564	pseudouridine synthase activity
GH913_06170	COG1446	asparaginase
GH913_06175	COG0339	signal peptide processing
GH913_06200	COG0475	glutathione-regulated potassium exporter activity
GH913_06210	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GH913_06215	COG2224	Isocitrate lyase
GH913_06220	COG3706	GGDEF domain
GH913_06250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GH913_06255	COG1960	acyl-CoA dehydrogenase activity
GH913_06325	COG0697	spore germination
GH913_06335	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GH913_06340	COG1846	Transcriptional regulator
GH913_06345	COG1764	response to oxidative stress
GH913_06375	COG2130	NADP-dependent
GH913_06390	COG1187	pseudouridine synthase activity
GH913_06405	COG1643	Atp-dependent helicase
GH913_06410	COG4807	Protein conserved in bacteria
GH913_06415	COG2351	hydroxyisourate hydrolase activity
GH913_06420	COG2072	flavoprotein involved in K transport
GH913_06440	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GH913_06475	COG1957	nucleoside hydrolase
GH913_06485	COG2252	PERMEase
GH913_06505	COG0084	hydrolase, TatD family'
GH913_06535	COG2814	Major facilitator Superfamily
GH913_06550	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GH913_06555	COG1902	pentaerythritol trinitrate reductase activity
GH913_06575	COG0745	RESPONSE REGULATOR receiver
GH913_06580	COG2205	protein histidine kinase activity
GH913_06585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH913_06595	COG1538	Outer membrane efflux protein
GH913_06610	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GH913_06615	COG0583	DNA-binding transcription factor activity
GH913_06645	COG0702	epimerase
GH913_06650	COG1733	regulation of RNA biosynthetic process
GH913_06710	COG0129	dihydroxy-acid dehydratase activity
GH913_06725	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GH913_06775	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GH913_06780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GH913_06805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GH913_06810	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GH913_06825	COG3485	protocatechuate 3,4-dioxygenase
GH913_06835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GH913_06840	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GH913_06850	COG1414	Transcriptional regulator
GH913_06870	COG0445	tRNA wobble uridine modification
GH913_06910	COG2267	carboxylic ester hydrolase activity
GH913_06920	COG0156	8-amino-7-oxononanoate synthase activity
GH913_06925	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GH913_06930	COG1040	competence protein
GH913_06935	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GH913_07005	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GH913_07075	COG1511	domain protein
GH913_07075	COG3264	Mechanosensitive ion channel
GH913_07080	COG1368	sulfuric ester hydrolase activity
GH913_07085	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GH913_07090	COG2354	Protein conserved in bacteria
GH913_07095	COG0745	RESPONSE REGULATOR receiver
GH913_07095	COG3706	GGDEF domain
GH913_07100	COG0297	glycogen (starch) synthase activity
GH913_07105	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GH913_07110	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GH913_07135	COG0702	epimerase
GH913_07140	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_07170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GH913_07175	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_07185	COG0513	Belongs to the DEAD box helicase family
GH913_07190	COG0508	dehydrogenase complex catalyzes the overall conversion of
GH913_07205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GH913_07215	COG3483	tryptophan 2,3-dioxygenase activity
GH913_07220	COG3104	oligopeptide transport
GH913_07240	COG2852	Protein conserved in bacteria
GH913_07245	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GH913_07260	COG1320	monovalent cation:proton antiporter activity
GH913_07265	COG2212	antiporter activity
GH913_07275	COG0651	ATP synthesis coupled electron transport
GH913_07280	COG1006	Multisubunit Na H antiporter MnhC subunit
GH913_07285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GH913_07285	COG2111	Na H antiporter
GH913_07305	COG3179	chitinase
GH913_07325	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GH913_07330	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GH913_07345	COG0456	acetyltransferase
GH913_07350	COG1597	lipid kinase activity
GH913_07375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GH913_07380	COG0134	indole-3-glycerol-phosphate synthase activity
GH913_07390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GH913_07395	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GH913_07405	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GH913_07410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GH913_07415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GH913_07430	COG1051	belongs to the nudix hydrolase family
GH913_07470	COG0316	Belongs to the HesB IscA family
GH913_07485	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GH913_07500	COG2814	Major facilitator Superfamily
GH913_07510	COG2814	Major facilitator Superfamily
GH913_07515	COG1289	transmembrane transporter activity
GH913_07525	COG0151	Belongs to the GarS family
GH913_07535	COG0138	bifunctional purine biosynthesis protein purh
GH913_07540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GH913_07545	COG2267	carboxylic ester hydrolase activity
GH913_07550	COG0671	phosphoesterase, PA-phosphatase related
GH913_07550	COG2453	phosphatase
GH913_07575	COG4589	Belongs to the CDS family
GH913_07580	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GH913_07605	COG2264	protein methyltransferase activity
GH913_07630	COG0439	Biotin carboxylase
GH913_07640	COG0511	ligase activity, forming carbon-carbon bonds
GH913_07645	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GH913_07655	COG1324	tolerance protein
GH913_07680	COG0300	oxidoreductase activity
GH913_07685	COG2356	endonuclease I
GH913_07695	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GH913_07700	COG0459	protein refolding
GH913_07720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GH913_07735	COG3386	PFAM SMP-30 Gluconolaconase
GH913_07745	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GH913_07750	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GH913_07765	COG0778	Nitroreductase
GH913_07770	COG2353	YceI-like domain
GH913_07795	COG3052	prosthetic group binding
GH913_07815	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GH913_07825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GH913_07835	COG1802	Transcriptional regulator
GH913_07840	COG0546	phosphoglycolate phosphatase activity
GH913_07930	COG4221	oxidoreductase activity
GH913_07945	COG4221	oxidoreductase activity
GH913_07955	COG0435	Glutathione S-transferase
GH913_07985	COG2409	Drug exporters of the RND superfamily
GH913_07990	COG0823	Involved in the tonB-independent uptake of proteins
GH913_07990	COG1506	peptidase
GH913_08000	COG3706	GGDEF domain
GH913_08025	COG0697	spore germination
GH913_08040	COG1113	amino acid transport
GH913_08050	COG0598	Magnesium transport protein CorA
GH913_08060	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GH913_08100	COG5001	Diguanylate cyclase
GH913_08105	COG0840	transmembrane signaling receptor activity
GH913_08110	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GH913_08110	COG5297	Belongs to the glycosyl hydrolase family 6
GH913_08115	COG0659	secondary active sulfate transmembrane transporter activity
GH913_08120	COG3706	GGDEF domain
GH913_08135	COG2943	transferase activity, transferring hexosyl groups
GH913_08145	COG3275	phosphorelay sensor kinase activity
GH913_08155	COG0181	hydroxymethylbilane synthase activity
GH913_08180	COG1505	serine-type exopeptidase activity
GH913_08190	COG0436	Aminotransferase
GH913_08200	COG2832	Protein of unknown function (DUF454)
GH913_08210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GH913_08220	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GH913_08225	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GH913_08230	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GH913_08255	COG2226	methyltransferase
GH913_08260	COG3300	MHYT domain
GH913_08260	COG5001	Diguanylate cyclase
GH913_08265	COG0308	aminopeptidase N
GH913_08300	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GH913_08310	COG3284	Transcriptional regulator
GH913_08320	COG1077	Cell shape determining protein MreB Mrl
GH913_08325	COG1792	Involved in formation and maintenance of cell shape
GH913_08340	COG0772	Belongs to the SEDS family
GH913_08350	COG2951	lytic endotransglycosylase activity
GH913_08355	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GH913_08360	COG1686	Belongs to the peptidase S11 family
GH913_08370	COG2921	Belongs to the UPF0250 family
GH913_08375	COG0321	lipoyl(octanoyl) transferase activity
GH913_08380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GH913_08395	COG0583	DNA-binding transcription factor activity
GH913_08405	COG1056	cytidyltransferase-related domain
GH913_08405	COG1051	belongs to the nudix hydrolase family
GH913_08440	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GH913_08445	COG0673	inositol 2-dehydrogenase activity
GH913_08450	COG2823	Periplasmic or secreted lipoprotein
GH913_08455	COG4251	negative regulation of phosphorylation
GH913_08460	COG0784	Response regulator, receiver
GH913_08465	COG4191	Histidine kinase
GH913_08470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GH913_08475	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_08525	COG1459	type II secretion system
GH913_08545	COG4795	General secretion pathway protein
GH913_08575	COG3250	beta-galactosidase activity
GH913_08600	COG1609	Transcriptional regulator
GH913_08605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GH913_08610	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GH913_08620	COG0617	tRNA 3'-terminal CCA addition
GH913_08625	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GH913_08630	COG1012	belongs to the aldehyde dehydrogenase family
GH913_08635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GH913_08650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GH913_08665	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GH913_08685	COG2205	protein histidine kinase activity
GH913_08690	COG0745	RESPONSE REGULATOR receiver
GH913_08715	COG3791	Glutathione-dependent formaldehyde-activating
GH913_08730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GH913_08740	COG0697	spore germination
GH913_08750	COG0488	(ABC) transporter
GH913_08760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GH913_08765	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GH913_08775	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GH913_08775	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GH913_08800	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GH913_08805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GH913_08810	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GH913_08830	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GH913_08835	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GH913_08840	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GH913_08860	COG0745	RESPONSE REGULATOR receiver
GH913_08870	COG0277	FAD linked oxidase domain protein
GH913_08875	COG1988	membrane-bound metal-dependent
GH913_08880	COG0792	nuclease activity
GH913_08915	COG2001	Belongs to the MraZ family
GH913_08920	COG0275	rRNA processing
GH913_08925	COG3116	cell division
GH913_08935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GH913_08940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GH913_08945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GH913_08955	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GH913_08960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GH913_08965	COG1181	Belongs to the D-alanine--D-alanine ligase family
GH913_08970	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GH913_08985	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GH913_08995	COG0739	heme binding
GH913_09000	COG0653	protein targeting
GH913_09005	COG0494	nUDIX hydrolase
GH913_09015	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GH913_09025	COG3321	synthase
GH913_09025	COG0604	alcohol dehydrogenase
GH913_09025	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_09045	COG0366	Alpha amylase catalytic
GH913_09075	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GH913_09085	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GH913_09125	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GH913_09135	COG4106	trans-aconitate 2-methyltransferase activity
GH913_09140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GH913_09150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH913_09155	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GH913_09160	COG0667	Aldo Keto reductase
GH913_09170	COG4771	TonB-dependent receptor
GH913_09190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GH913_09195	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GH913_09205	COG2175	clavaminate synthase activity
GH913_09215	COG4181	ATPase activity
GH913_09240	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GH913_09260	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GH913_09265	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GH913_09280	COG3829	transcription factor binding
GH913_09290	COG1116	anion transmembrane transporter activity
GH913_09295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GH913_09305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GH913_09310	COG0431	NADPH-dependent FMN reductase
GH913_09335	COG0747	negative chemotaxis
GH913_09355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GH913_09360	COG2967	ApaG domain
GH913_09365	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GH913_09370	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GH913_09375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GH913_09380	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GH913_09395	COG0123	including yeast histone deacetylase and acetoin utilization protein
GH913_09400	COG2096	Adenosyltransferase
GH913_09415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GH913_09420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GH913_09450	COG3384	dioxygenase
GH913_09455	COG0583	DNA-binding transcription factor activity
GH913_09460	COG0318	PFAM AMP-dependent synthetase and ligase
GH913_09470	COG1024	Enoyl-CoA hydratase
GH913_09490	COG3386	PFAM SMP-30 Gluconolaconase
GH913_09525	COG0697	spore germination
GH913_09530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GH913_09545	COG3706	GGDEF domain
GH913_09545	COG0745	RESPONSE REGULATOR receiver
GH913_09555	COG2197	response regulator
GH913_09565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GH913_09575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GH913_09580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GH913_09585	COG0583	DNA-binding transcription factor activity
GH913_09590	COG3634	alkyl hydroperoxide reductase activity
GH913_09600	COG2890	protein-(glutamine-N5) methyltransferase activity
GH913_09620	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GH913_09620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GH913_09650	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GH913_09670	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GH913_09675	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GH913_09690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GH913_09705	COG1404	Belongs to the peptidase S8 family
GH913_09710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GH913_09735	COG1295	ribonuclease BN
GH913_09740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GH913_09745	COG1254	Belongs to the acylphosphatase family
GH913_09760	COG0521	Mo-molybdopterin cofactor biosynthetic process
GH913_09770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GH913_09775	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GH913_09785	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GH913_09790	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GH913_09800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GH913_09805	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GH913_09810	COG0193	aminoacyl-tRNA hydrolase activity
GH913_09815	COG0012	GTP binding
GH913_09835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GH913_09845	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GH913_09850	COG0250	Participates in transcription elongation, termination and antitermination
GH913_09855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GH913_09860	COG0081	regulation of translation
GH913_09865	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GH913_09870	COG0222	ribosome binding
GH913_09875	COG0085	RNA polymerase activity
GH913_09880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GH913_09885	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GH913_09890	COG0049	tRNA binding
GH913_09895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GH913_09900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GH913_09905	COG0051	transcription antitermination factor activity, RNA binding
GH913_09910	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GH913_09915	COG0088	Forms part of the polypeptide exit tunnel
GH913_09920	COG0089	rRNA binding
GH913_09925	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GH913_09930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GH913_09935	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GH913_09940	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GH913_09945	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GH913_09950	COG0255	Belongs to the universal ribosomal protein uL29 family
GH913_09955	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GH913_09960	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GH913_09965	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GH913_09970	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GH913_09975	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GH913_09980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GH913_09985	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GH913_09990	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GH913_09995	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GH913_10000	COG1841	ribosomal large subunit assembly
GH913_10005	COG0200	Binds to the 23S rRNA
GH913_10010	COG0201	protein transport
GH913_10015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GH913_10020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GH913_10025	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GH913_10030	COG0202	RNA polymerase activity
GH913_10035	COG0203	ribosomal protein L17
GH913_10040	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GH913_10050	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GH913_10075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GH913_10080	COG0039	L-malate dehydrogenase activity
GH913_10085	COG0625	glutathione transferase activity
GH913_10095	COG0446	pyridine nucleotide-disulphide oxidoreductase
GH913_10095	COG1902	pentaerythritol trinitrate reductase activity
GH913_10100	COG0604	alcohol dehydrogenase
GH913_10125	COG0156	8-amino-7-oxononanoate synthase activity
GH913_10130	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GH913_10135	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GH913_10140	COG4208	sulfate ABC transporter
GH913_10145	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GH913_10155	COG1063	alcohol dehydrogenase
GH913_10185	COG0406	alpha-ribazole phosphatase activity
GH913_10195	COG0285	dihydrofolate synthase activity
GH913_10230	COG3291	Pkd domain containing protein
GH913_10240	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GH913_10245	COG0671	phosphoesterase, PA-phosphatase related
GH913_10260	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GH913_10275	COG4783	chaperone-mediated protein folding
GH913_10290	COG0473	3-isopropylmalate dehydrogenase activity
GH913_10325	COG3852	Histidine kinase
GH913_10335	COG0544	peptidyl-prolyl cis-trans isomerase activity
GH913_10340	COG0740	serine-type endopeptidase activity
GH913_10345	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GH913_10375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GH913_10385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH913_10395	COG0328	RNA-DNA hybrid ribonuclease activity
GH913_10400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GH913_10405	COG0631	protein serine/threonine phosphatase activity
GH913_10420	COG0859	PFAM glycosyl transferase family 9
GH913_10425	COG3642	lipopolysaccharide core region biosynthetic process
GH913_10430	COG1234	tRNA 3'-trailer cleavage
GH913_10435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GH913_10440	COG0315	cyclic pyranopterin monophosphate synthase activity
GH913_10445	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GH913_10450	COG0314	molybdopterin synthase activity
GH913_10580	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GH913_10585	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GH913_10590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GH913_10595	COG0537	adenosine 5'-monophosphoramidase activity
GH913_10615	COG0714	Associated with various cellular activities
GH913_10635	COG0424	maF-like protein
GH913_10640	COG1399	metal-binding, possibly nucleic acid-binding protein
GH913_10645	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GH913_10650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GH913_10665	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_10670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GH913_10680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GH913_10685	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GH913_10710	COG3829	transcription factor binding
GH913_10755	COG2373	Large extracellular alpha-helical protein
GH913_10770	COG4953	penicillin-binding protein 1C
GH913_10780	COG0678	peroxiredoxin activity
GH913_10800	COG0330	HflC and HflK could
GH913_10805	COG0330	HflC and HflK could
GH913_10815	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GH913_10820	COG0308	aminopeptidase N
GH913_10825	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_10830	COG1309	transcriptional regulator
GH913_10875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GH913_10880	COG1196	nuclear chromosome segregation
GH913_10890	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GH913_10910	COG1309	transcriptional regulator
GH913_10915	COG0406	alpha-ribazole phosphatase activity
GH913_10915	COG0328	RNA-DNA hybrid ribonuclease activity
GH913_10920	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GH913_10935	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_10940	COG3537	Alpha-1,2-mannosidase
GH913_10945	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_10955	COG0492	ferredoxin-NADP+ reductase activity
GH913_10965	COG3287	FIST C domain
GH913_10965	COG2199	diguanylate cyclase activity
GH913_10965	COG2200	EAL domain
GH913_10980	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GH913_10985	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GH913_10990	COG2080	2 iron, 2 sulfur cluster binding
GH913_11025	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GH913_11040	COG0587	DNA-directed DNA polymerase activity
GH913_11060	COG1297	OPT oligopeptide transporter protein
GH913_11075	COG0823	Involved in the tonB-independent uptake of proteins
GH913_11075	COG1506	peptidase
GH913_11100	COG1917	Cupin 2, conserved barrel domain protein
GH913_11100	COG2207	Transcriptional regulator
GH913_11130	COG0753	catalase activity
GH913_11135	COG0656	L-ascorbic acid biosynthetic process
GH913_11145	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GH913_11145	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GH913_11150	COG2814	Major facilitator Superfamily
GH913_11165	COG2194	sulfuric ester hydrolase activity
GH913_11180	COG0745	RESPONSE REGULATOR receiver
GH913_11185	COG0642	Histidine kinase
GH913_11195	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GH913_11200	COG2894	cell division
GH913_11205	COG0850	regulation of cytokinetic process
GH913_11215	COG4585	Histidine kinase
GH913_11220	COG2197	response regulator
GH913_11235	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GH913_11265	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GH913_11275	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GH913_11295	COG1946	Acyl-CoA thioesterase
GH913_11310	COG0824	Thioesterase
GH913_11315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GH913_11320	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GH913_11325	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GH913_11330	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GH913_11335	COG0268	Binds directly to 16S ribosomal RNA
GH913_11340	COG0728	peptidoglycan biosynthetic process
GH913_11345	COG0196	riboflavin kinase activity
GH913_11350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GH913_11355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GH913_11360	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GH913_11510	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GH913_11510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GH913_11565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GH913_11570	COG1845	cytochrome c oxidase, subunit III
GH913_11575	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GH913_11590	COG3152	Membrane
GH913_11600	COG2207	Transcriptional regulator
GH913_11605	COG0326	Molecular chaperone. Has ATPase activity
GH913_11615	COG1366	Belongs to the anti-sigma-factor antagonist family
GH913_11620	COG1366	Belongs to the anti-sigma-factor antagonist family
GH913_11625	COG2172	sigma factor antagonist activity
GH913_11650	COG4771	TonB-dependent receptor
GH913_11660	COG5507	3-demethylubiquinone-9 3-methyltransferase
GH913_11665	COG3706	GGDEF domain
GH913_11665	COG0745	RESPONSE REGULATOR receiver
GH913_11675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GH913_11680	COG3437	response regulator, receiver
GH913_11680	COG4999	Histidine kinase
GH913_11680	COG2205	protein histidine kinase activity
GH913_11680	COG3850	Histidine kinase
GH913_11685	COG4191	Histidine kinase
GH913_11685	COG0784	Response regulator, receiver
GH913_11715	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GH913_11720	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GH913_11730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GH913_11735	COG0228	four-way junction DNA binding
GH913_11740	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GH913_11745	COG0336	Belongs to the RNA methyltransferase TrmD family
GH913_11750	COG0335	large ribosomal subunit rRNA binding
GH913_11755	COG0534	Mate efflux family protein
GH913_11775	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GH913_11785	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GH913_11840	COG3250	beta-galactosidase activity
GH913_11845	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GH913_11865	COG1960	acyl-CoA dehydrogenase activity
GH913_11890	COG1024	Enoyl-CoA hydratase
GH913_11890	COG1250	3-hydroxyacyl-CoA dehydrogenase
GH913_11905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GH913_11910	COG0481	GTPase activity
GH913_11925	COG0571	ribonuclease III activity
GH913_11930	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GH913_11935	COG1381	Involved in DNA repair and RecF pathway recombination
GH913_11945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GH913_11955	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GH913_11960	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
GH913_11965	COG3046	protein related to deoxyribodipyrimidine photolyase
GH913_11970	COG1472	Belongs to the glycosyl hydrolase 3 family
GH913_11980	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GH913_11985	COG1278	Cold shock
GH913_11990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GH913_12000	COG1201	RNA secondary structure unwinding
GH913_12005	COG1793	dna ligase
GH913_12015	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GH913_12015	COG1793	dna ligase
GH913_12030	COG0745	RESPONSE REGULATOR receiver
GH913_12030	COG3706	GGDEF domain
GH913_12045	COG0183	Belongs to the thiolase family
GH913_12070	COG1451	nucleotide metabolic process
GH913_12075	COG5487	UPF0391 membrane protein
GH913_12085	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GH913_12100	COG1077	Cell shape determining protein MreB Mrl
GH913_12105	COG1047	Peptidyl-prolyl cis-trans
GH913_12115	COG2824	Alkylphosphonate utilization operon protein PhnA
GH913_12125	COG2814	Major facilitator Superfamily
GH913_12160	COG0392	lysyltransferase activity
GH913_12160	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GH913_12170	COG0251	oxidation-reduction process
GH913_12175	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GH913_12190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GH913_12215	COG1595	DNA-templated transcription, initiation
GH913_12230	COG2878	Part of a membrane complex involved in electron transport
GH913_12240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GH913_12240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GH913_12255	COG1131	(ABC) transporter
GH913_12260	COG0346	lactoylglutathione lyase activity
GH913_12265	COG0833	amino acid
GH913_12270	COG2040	homocysteine
GH913_12280	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GH913_12300	COG1695	Transcriptional regulator
GH913_12335	COG0825	malonyl-CoA metabolic process
GH913_12345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GH913_12350	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GH913_12355	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GH913_12360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GH913_12365	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GH913_12380	COG0750	zinc metalloprotease
GH913_12385	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GH913_12390	COG0575	Belongs to the CDS family
GH913_12395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GH913_12400	COG0233	cytoplasmic translational termination
GH913_12405	COG0528	UMP kinase activity
GH913_12410	COG3706	GGDEF domain
GH913_12410	COG0745	RESPONSE REGULATOR receiver
GH913_12415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GH913_12420	COG0052	Belongs to the universal ribosomal protein uS2 family
GH913_12455	COG0024	Methionine aminopeptidase
GH913_12460	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GH913_12470	COG1393	Belongs to the ArsC family
GH913_12475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GH913_12480	COG0367	asparagine synthase
GH913_12490	COG4774	siderophore transport
GH913_12505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GH913_12530	COG1566	PFAM secretion protein HlyD family protein
GH913_12535	COG2814	Major facilitator Superfamily
GH913_12555	COG3104	oligopeptide transport
GH913_12585	COG0339	signal peptide processing
GH913_12590	COG0386	Belongs to the glutathione peroxidase family
GH913_12655	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GH913_12660	COG0084	hydrolase, TatD family'
GH913_12675	COG1960	acyl-CoA dehydrogenase activity
GH913_12695	COG0367	asparagine synthase
GH913_12705	COG0305	Participates in initiation and elongation during chromosome replication
GH913_12710	COG0415	Belongs to the DNA photolyase family
GH913_12725	COG0583	DNA-binding transcription factor activity
GH913_12760	COG3706	GGDEF domain
GH913_12770	COG3706	GGDEF domain
GH913_12830	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GH913_12845	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GH913_12855	COG0497	DNA recombination
GH913_12860	COG1420	regulation of RNA biosynthetic process
GH913_12865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GH913_12870	COG0443	Heat shock 70 kDa protein
GH913_12875	COG0484	heat shock protein binding
GH913_12885	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GH913_12915	COG0583	DNA-binding transcription factor activity
GH913_12920	COG1132	(ABC) transporter
GH913_12955	COG2850	peptidyl-arginine hydroxylation
GH913_12975	COG1253	flavin adenine dinucleotide binding
GH913_13005	COG1131	(ABC) transporter
GH913_13010	COG1725	Transcriptional regulator
GH913_13020	COG0386	Belongs to the glutathione peroxidase family
GH913_13035	COG2900	Belongs to the SlyX family
GH913_13060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH913_13070	COG1410	methionine synthase
GH913_13070	COG0646	methionine synthase
GH913_13075	COG0646	methionine synthase
GH913_13075	COG1410	methionine synthase
GH913_13085	COG1960	acyl-CoA dehydrogenase activity
GH913_13090	COG1960	acyl-CoA dehydrogenase activity
GH913_13095	COG1960	acyl-CoA dehydrogenase activity
GH913_13110	COG0557	exoribonuclease II activity
GH913_13120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GH913_13125	COG3706	GGDEF domain
GH913_13130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GH913_13140	COG0704	Plays a role in the regulation of phosphate uptake
GH913_13145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GH913_13150	COG0581	inorganic phosphate transmembrane transporter activity
GH913_13155	COG0573	inorganic phosphate transmembrane transporter activity
GH913_13160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GH913_13185	COG0659	secondary active sulfate transmembrane transporter activity
GH913_13190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GH913_13200	COG1024	Enoyl-CoA hydratase
GH913_13210	COG0494	nUDIX hydrolase
GH913_13255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GH913_13255	COG0116	Belongs to the methyltransferase superfamily
GH913_13260	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GH913_13285	COG2925	Exonuclease
GH913_13290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GH913_13295	COG3844	kynureninase activity
GH913_13305	COG0662	Cupin 2, conserved barrel domain protein
GH913_13310	COG0288	reversible hydration of carbon dioxide
GH913_13380	COG2808	Putative FMN-binding domain
GH913_13400	COG0017	Asparaginyl-tRNA synthetase
GH913_13405	COG0316	Belongs to the HesB IscA family
GH913_13410	COG0360	Binds together with S18 to 16S ribosomal RNA
GH913_13415	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GH913_13420	COG0359	binds to the 23S rRNA
GH913_13430	COG3115	cell septum assembly
GH913_13445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GH913_13450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GH913_13455	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GH913_13465	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GH913_13475	COG4993	Dehydrogenase
GH913_13485	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GH913_13495	COG2986	histidine ammonia-lyase
GH913_13500	COG1228	amidohydrolase
GH913_13535	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
GH913_13540	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GH913_13545	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GH913_13550	COG1605	Chorismate mutase
GH913_13550	COG0077	Prephenate dehydratase
GH913_13555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GH913_13570	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GH913_13575	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GH913_13580	COG0583	DNA-binding transcription factor activity
GH913_13595	COG0840	transmembrane signaling receptor activity
GH913_13620	COG5002	protein histidine kinase activity
GH913_13620	COG2205	protein histidine kinase activity
GH913_13620	COG0784	Response regulator, receiver
GH913_13630	COG0784	Response regulator, receiver
GH913_13630	COG4191	Histidine kinase
GH913_13645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GH913_13655	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GH913_13665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GH913_13680	COG1595	DNA-templated transcription, initiation
GH913_13715	COG2951	lytic endotransglycosylase activity
GH913_13785	COG2244	polysaccharide biosynthetic process
GH913_13815	COG2264	protein methyltransferase activity
GH913_13840	COG1136	(ABC) transporter
GH913_13845	COG1132	(ABC) transporter
GH913_13850	COG0477	Major facilitator Superfamily
GH913_13855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GH913_13870	COG1253	flavin adenine dinucleotide binding
GH913_13880	COG0306	phosphate transporter
GH913_13905	COG0504	CTP synthase activity
GH913_13910	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GH913_13920	COG0148	phosphopyruvate hydratase activity
GH913_13925	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GH913_13930	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GH913_13935	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GH913_13940	COG0585	pseudouridine synthase activity
GH913_13945	COG2840	Smr protein MutS2
GH913_13950	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GH913_13955	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GH913_13960	COG1238	metal cluster binding
GH913_13975	COG1534	Rna-binding protein
GH913_13980	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GH913_13985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GH913_13990	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GH913_13995	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GH913_14000	COG1923	regulation of RNA biosynthetic process
GH913_14005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GH913_14010	COG1546	Belongs to the CinA family
GH913_14020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GH913_14025	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GH913_14030	COG2137	regulation of response to DNA damage stimulus
GH913_14035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GH913_14040	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GH913_14055	COG1741	Belongs to the pirin family
GH913_14060	COG0583	DNA-binding transcription factor activity
GH913_14085	COG0351	phosphomethylpyrimidine kinase
GH913_14100	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GH913_14105	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GH913_14120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GH913_14130	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GH913_14135	COG3734	2-keto-3-deoxy-galactonokinase
GH913_14145	COG4948	Mandelate Racemase Muconate Lactonizing
GH913_14150	COG0800	Aldolase
GH913_14185	COG1501	Belongs to the glycosyl hydrolase 31 family
GH913_14195	COG1070	Carbohydrate kinase
GH913_14200	COG2115	Belongs to the xylose isomerase family
GH913_14205	COG0477	Major facilitator Superfamily
GH913_14225	COG0860	N-Acetylmuramoyl-L-alanine amidase
GH913_14230	COG1469	GTP cyclohydrolase I activity
GH913_14250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GH913_14255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GH913_14260	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GH913_14265	COG0166	Belongs to the GPI family
GH913_14285	COG1472	Belongs to the glycosyl hydrolase 3 family
GH913_14295	COG2203	Gaf domain
GH913_14295	COG3706	GGDEF domain
GH913_14295	COG4251	negative regulation of phosphorylation
GH913_14295	COG5001	Diguanylate cyclase
GH913_14300	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GH913_14305	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
GH913_14315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GH913_14320	COG0671	phosphoesterase, PA-phosphatase related
GH913_14335	COG1794	racemase activity, acting on amino acids and derivatives
GH913_14340	COG0697	spore germination
GH913_14345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GH913_14350	COG0167	dihydroorotate dehydrogenase activity
GH913_14365	COG1012	belongs to the aldehyde dehydrogenase family
GH913_14380	COG1215	transferase activity, transferring glycosyl groups
GH913_14385	COG0726	polysaccharide deacetylase
GH913_14385	COG1649	PFAM Uncharacterised BCR, COG1649
GH913_14435	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GH913_14445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GH913_14450	COG0124	histidyl-tRNA synthetase
GH913_14460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GH913_14465	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GH913_14470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GH913_14475	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GH913_14475	COG0131	Imidazoleglycerol-phosphate dehydratase
GH913_14480	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GH913_14485	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GH913_14490	COG0107	imidazoleglycerol-phosphate synthase activity
GH913_14495	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GH913_14495	COG0140	phosphoribosyl-ATP diphosphatase activity
GH913_14510	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
GH913_14515	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GH913_14520	COG0235	Class ii aldolase
GH913_14525	COG0531	amino acid
GH913_14530	COG0531	amino acid
GH913_14540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GH913_14545	COG0277	FAD linked oxidase domain protein
GH913_14565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GH913_14610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GH913_14615	COG2258	MOSC domain
GH913_14620	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GH913_14625	COG0505	Belongs to the CarA family
GH913_14635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GH913_14640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GH913_14650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GH913_14685	COG3279	Response regulator of the LytR AlgR family
GH913_14695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GH913_14705	COG2205	protein histidine kinase activity
GH913_14705	COG0784	Response regulator, receiver
GH913_14705	COG2198	Histidine kinase
GH913_14710	COG1024	Enoyl-CoA hydratase
GH913_14715	COG0318	PFAM AMP-dependent synthetase and ligase
GH913_14745	COG2267	carboxylic ester hydrolase activity
GH913_14755	COG2201	protein-glutamate methylesterase activity
GH913_14760	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GH913_14770	COG0840	transmembrane signaling receptor activity
GH913_14780	COG0835	chemotaxis
GH913_14795	COG0840	transmembrane signaling receptor activity
GH913_14800	COG0840	transmembrane signaling receptor activity
GH913_14805	COG0840	transmembrane signaling receptor activity
GH913_14810	COG0840	transmembrane signaling receptor activity
GH913_14820	COG0840	transmembrane signaling receptor activity
GH913_14825	COG0840	transmembrane signaling receptor activity
GH913_14830	COG0840	transmembrane signaling receptor activity
GH913_14840	COG0840	transmembrane signaling receptor activity
GH913_14845	COG0840	transmembrane signaling receptor activity
GH913_14845	COG0840	transmembrane signaling receptor activity
GH913_14860	COG0840	transmembrane signaling receptor activity
GH913_14870	COG0745	RESPONSE REGULATOR receiver
GH913_14880	COG0835	chemotaxis
GH913_14885	COG1192	Involved in chromosome partitioning
GH913_14890	COG1360	Flagellar Motor Protein
GH913_14895	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GH913_14910	COG1192	Involved in chromosome partitioning
GH913_14980	COG2198	Histidine kinase
GH913_14980	COG0643	Histidine kinase
GH913_15000	COG0455	bacterial-type flagellum organization
GH913_15010	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GH913_15025	COG5001	Diguanylate cyclase
GH913_15025	COG3300	MHYT domain
GH913_15030	COG5001	Diguanylate cyclase
GH913_15030	COG3300	MHYT domain
GH913_15035	COG1684	flagellar biosynthetic protein fliR
GH913_15040	COG1987	bacterial-type flagellum assembly
GH913_15050	COG3190	flagellar
GH913_15100	COG1677	Flagellar hook-basal body complex protein FliE
GH913_15145	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_15150	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_15155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GH913_15170	COG2204	response regulator
GH913_15175	COG2201	protein-glutamate methylesterase activity
GH913_15205	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GH913_15215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GH913_15220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GH913_15230	COG1705	Flagellar rod assembly protein muramidase FlgJ
GH913_15230	COG3951	Flagellar rod assembly protein muramidase FlgJ
GH913_15235	COG1706	bacterial-type flagellum-dependent cell motility
GH913_15240	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GH913_15245	COG4786	Flagellar basal body rod
GH913_15250	COG4787	bacterial-type flagellum-dependent cell motility
GH913_15255	COG1749	Flagellar hook protein flgE
GH913_15260	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GH913_15265	COG1558	bacterial-type flagellum-dependent cell motility
GH913_15275	COG0835	chemotaxis
GH913_15275	COG0784	Response regulator, receiver
GH913_15295	COG5002	protein histidine kinase activity
GH913_15325	COG2915	High frequency lysogenization protein hflD homolog
GH913_15330	COG0482	sulfurtransferase activity
GH913_15340	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GH913_15345	COG0542	response to heat
GH913_15350	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GH913_15355	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GH913_15365	COG0492	ferredoxin-NADP+ reductase activity
GH913_15370	COG1674	ftsk spoiiie
GH913_15380	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GH913_15390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GH913_15395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GH913_15400	COG0183	Belongs to the thiolase family
GH913_15405	COG1024	Enoyl-CoA hydratase
GH913_15405	COG1250	3-hydroxyacyl-CoA dehydrogenase
GH913_15415	COG0105	UTP biosynthetic process
GH913_15420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GH913_15430	COG1426	Protein conserved in bacteria
GH913_15440	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GH913_15445	COG1160	GTP binding
GH913_15450	COG0303	'Molybdopterin
GH913_15455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GH913_15645	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GH913_15680	COG4644	lycopene metabolic process
GH913_15780	COG0708	Exodeoxyribonuclease III
GH913_15790	COG0303	'Molybdopterin
GH913_15795	COG0746	molybdenum cofactor guanylyltransferase activity
GH913_15805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GH913_15805	COG1648	precorrin-2 dehydrogenase activity
GH913_15830	COG3685	Protein conserved in bacteria
GH913_15850	COG2203	Gaf domain
GH913_15850	COG3706	GGDEF domain
GH913_15850	COG4251	negative regulation of phosphorylation
GH913_15850	COG5001	Diguanylate cyclase
GH913_15870	COG4566	intracellular signal transduction
GH913_15890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH913_15910	COG3279	Response regulator of the LytR AlgR family
GH913_15945	COG1238	metal cluster binding
GH913_16065	COG0316	Belongs to the HesB IscA family
GH913_16065	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GH913_16070	COG2154	pterin-4-alpha-carbinolamine dehydratase
GH913_16080	COG0428	transporter
GH913_16085	COG3064	Membrane
GH913_16095	COG1530	ribonuclease E activity
GH913_16125	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GH913_16375	COG0583	DNA-binding transcription factor activity
GH913_16380	COG0477	Major facilitator Superfamily
GH913_16395	COG1960	acyl-CoA dehydrogenase activity
GH913_16405	COG2816	NAD+ diphosphatase activity
GH913_16415	COG2814	Major facilitator Superfamily
GH913_16540	COG3593	DNA synthesis involved in DNA repair
GH913_16560	COG0583	DNA-binding transcription factor activity
GH913_16575	COG0582	viral genome integration into host DNA
GH913_16595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GH913_16600	COG0322	excinuclease ABC activity
GH913_16610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GH913_16615	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GH913_16620	COG1663	tetraacyldisaccharide 4'-kinase activity
GH913_16625	COG1132	(ABC) transporter
GH913_16635	COG0811	peptide transport
GH913_16650	COG1136	(ABC) transporter
GH913_16655	COG4591	ABC-type transport system involved in lipoprotein release permease component
GH913_16665	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GH913_16670	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GH913_16685	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GH913_16710	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GH913_16715	COG0837	glucose binding
GH913_16720	COG0363	glucosamine-6-phosphate deaminase activity
GH913_16725	COG0129	dihydroxy-acid dehydratase activity
GH913_16730	COG0800	Aldolase
GH913_16805	COG0784	Response regulator, receiver
GH913_16805	COG2205	protein histidine kinase activity
GH913_16815	COG2183	response to ionizing radiation
GH913_16825	COG0723	plastoquinol--plastocyanin reductase activity
GH913_16825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH913_16840	COG3243	poly(R)-hydroxyalkanoic acid synthase
GH913_16850	COG1183	phosphatidylcholine synthase activity
GH913_16855	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_16870	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GH913_16880	COG0668	transmembrane transport
GH913_16890	COG2814	Major facilitator Superfamily
GH913_16910	COG1914	H( )-stimulated, divalent metal cation uptake system
GH913_16915	COG1321	iron dependent repressor
GH913_16920	COG0590	tRNA wobble adenosine to inosine editing
GH913_16925	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GH913_16935	COG1335	isochorismatase
GH913_16955	COG2197	response regulator
GH913_16975	COG0583	DNA-binding transcription factor activity
GH913_16980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GH913_16985	COG3002	Belongs to the UPF0753 family
GH913_17010	COG3846	protein secretion by the type IV secretion system
GH913_17025	COG3451	type IV secretory pathway VirB4
GH913_17070	COG0667	Aldo Keto reductase
GH913_17115	COG0582	viral genome integration into host DNA
GH913_17120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GH913_17120	COG0519	Catalyzes the synthesis of GMP from XMP
GH913_17130	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GH913_17140	COG0475	glutathione-regulated potassium exporter activity
GH913_17140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GH913_17145	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GH913_17155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GH913_17160	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GH913_17170	COG0776	regulation of translation
GH913_17175	COG0539	negative regulation of cytoplasmic translation
GH913_17180	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GH913_17185	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GH913_17195	COG2957	Belongs to the agmatine deiminase family
GH913_17200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GH913_17225	COG0395	ABC-type sugar transport system, permease component
GH913_17230	COG1175	transmembrane transport
GH913_17260	COG2350	Protein conserved in bacteria
GH913_17265	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GH913_17270	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GH913_17275	COG1187	pseudouridine synthase activity
GH913_17295	COG0436	Aminotransferase
GH913_17300	COG4133	protoheme IX ABC transporter activity
GH913_17320	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GH913_17325	COG1138	Cytochrome C-type biogenesis protein
GH913_17345	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GH913_17350	COG1278	Cold shock
GH913_17355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GH913_17360	COG4988	ABC transporter
GH913_17370	COG1294	oxidase, subunit
GH913_17395	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GH913_17400	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GH913_17410	COG0165	Argininosuccinate lyase
GH913_17415	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GH913_17425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GH913_17440	COG0137	argininosuccinate synthase activity
GH913_17445	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GH913_17455	COG0215	cysteine-tRNA ligase activity
GH913_17460	COG2166	iron-sulfur cluster assembly
GH913_17470	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GH913_17475	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GH913_17480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GH913_17505	COG4302	ethanolamine ammonia-lyase activity
GH913_17565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GH913_17570	COG0402	S-adenosylhomocysteine deaminase activity
GH913_17580	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GH913_17585	COG1509	lysine 2,3-aminomutase activity
GH913_17590	COG3300	MHYT domain
GH913_17590	COG5001	Diguanylate cyclase
GH913_17605	COG0483	inositol monophosphate 1-phosphatase activity
GH913_17630	COG0513	Belongs to the DEAD box helicase family
GH913_17635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GH913_17640	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GH913_17650	COG0625	glutathione transferase activity
GH913_17660	COG4681	YaeQ
GH913_17665	COG2081	HI0933 family
GH913_17675	COG0501	Belongs to the peptidase M48B family
GH913_17680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GH913_17685	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_17710	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GH913_17715	COG0860	N-Acetylmuramoyl-L-alanine amidase
GH913_17720	COG0802	atpase or kinase
GH913_17725	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GH913_17725	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GH913_17730	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GH913_17735	COG1570	exodeoxyribonuclease VII activity
GH913_17745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GH913_17865	COG0835	chemotaxis
GH913_17870	COG0840	transmembrane signaling receptor activity
GH913_17875	COG2094	Belongs to the DNA glycosylase MPG family
GH913_17880	COG1201	RNA secondary structure unwinding
GH913_17900	COG2969	positive regulation of protein catabolic process
GH913_17905	COG0625	glutathione transferase activity
GH913_17910	COG2857	Cytochrome c1
GH913_17915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GH913_17920	COG0723	plastoquinol--plastocyanin reductase activity
GH913_17925	COG0741	lytic transglycosylase activity
GH913_17940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GH913_17945	COG1702	phosphate starvation-inducible protein PhoH
GH913_17955	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GH913_17965	COG4535	Mg2 and Co2 transporter CorC
GH913_17980	COG1012	belongs to the aldehyde dehydrogenase family
GH913_17985	COG1177	transmembrane transport
GH913_17990	COG1176	ABC-type spermidine putrescine transport system, permease component I
GH913_17995	COG3842	ATPase activity
GH913_18015	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GH913_18030	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GH913_18035	COG0174	glutamine synthetase
GH913_18040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH913_18045	COG3706	GGDEF domain
GH913_18045	COG0745	RESPONSE REGULATOR receiver
GH913_18050	COG2703	oxygen carrier activity
GH913_18055	COG0477	Major facilitator Superfamily
GH913_18065	COG0243	molybdopterin cofactor binding
GH913_18070	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GH913_18095	COG2733	membrane
GH913_18100	COG0784	Response regulator, receiver
GH913_18100	COG5002	protein histidine kinase activity
GH913_18100	COG2205	protein histidine kinase activity
GH913_18110	COG0477	Major facilitator Superfamily
GH913_18120	COG2902	Dehydrogenase
GH913_18130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH913_18135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GH913_18140	COG1609	Transcriptional regulator
GH913_18145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GH913_18145	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GH913_18150	COG1105	Belongs to the carbohydrate kinase PfkB family
GH913_18155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GH913_18155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GH913_18205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GH913_18215	COG1862	Preprotein translocase
GH913_18220	COG0343	queuine tRNA-ribosyltransferase activity
GH913_18225	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GH913_18270	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GH913_18275	COG3291	Pkd domain containing protein
GH913_18280	COG0405	Gamma-glutamyltransferase
GH913_18285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GH913_18295	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GH913_18300	COG0742	ribosomal rna small subunit methyltransferase
GH913_18305	COG0326	Molecular chaperone. Has ATPase activity
GH913_18340	COG4206	TonB-dependent receptor
GH913_18405	COG0531	amino acid
GH913_18420	COG0006	proline dipeptidase activity
GH913_18430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GH913_18445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH913_18450	COG3938	Belongs to the proline racemase family
GH913_18460	COG0552	protein localization to endoplasmic reticulum
GH913_18465	COG1194	a g-specific adenine glycosylase
GH913_18470	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GH913_18475	COG4191	Histidine kinase
GH913_18475	COG0784	Response regulator, receiver
GH913_18490	COG0322	excinuclease ABC activity
GH913_18505	COG3040	lipid binding
GH913_18520	COG1960	acyl-CoA dehydrogenase activity
GH913_18530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GH913_18550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GH913_18555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH913_18560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GH913_18595	COG0438	transferase activity, transferring glycosyl groups
GH913_18600	COG0438	transferase activity, transferring glycosyl groups
GH913_18645	COG0776	regulation of translation
GH913_18650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GH913_18650	COG0072	phenylalanine-tRNA ligase activity
GH913_18655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GH913_18660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GH913_18665	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GH913_18670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GH913_18675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GH913_18700	COG1082	Xylose isomerase domain protein TIM barrel
GH913_18765	COG3702	type iv secretory pathway
GH913_18785	COG2948	multi-organism process
GH913_18805	COG3505	Type IV secretory pathway VirD4
GH913_18820	COG0556	nucleotide-excision repair
GH913_18865	COG1611	Belongs to the LOG family
GH913_18875	COG2095	MarC family integral membrane protein
GH913_18885	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GH913_18890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GH913_18920	COG1185	polyribonucleotide nucleotidyltransferase activity
GH913_18925	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GH913_18930	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GH913_18935	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GH913_18940	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GH913_18945	COG0195	Participates in both transcription termination and antitermination
GH913_18950	COG0779	Required for maturation of 30S ribosomal subunits
GH913_18960	COG1007	ATP synthesis coupled electron transport
GH913_18975	COG0713	ATP synthesis coupled electron transport
GH913_18985	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH913_18990	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GH913_19000	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GH913_19005	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GH913_19010	COG0649	NAD binding
GH913_19015	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH913_19020	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH913_19025	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH913_19040	COG0149	triose-phosphate isomerase activity
GH913_19045	COG0300	oxidoreductase activity
GH913_19075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GH913_19080	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GH913_19085	COG0159	tryptophan synthase activity
GH913_19095	COG0133	tryptophan synthase activity
GH913_19105	COG0135	phosphoribosylanthranilate isomerase activity
GH913_19110	COG0101	tRNA pseudouridine synthase activity
GH913_19130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GH913_19135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GH913_19140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GH913_19145	COG2890	protein-(glutamine-N5) methyltransferase activity
GH913_19155	COG0688	phosphatidylethanolamine metabolic process
GH913_19175	COG0494	nUDIX hydrolase
GH913_19195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GH913_19200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GH913_19210	COG2336	PFAM SpoVT AbrB
GH913_19225	COG1404	Belongs to the peptidase S8 family
GH913_19265	COG0717	Belongs to the dCTP deaminase family
GH913_19270	COG0489	protein tyrosine kinase activity
GH913_19290	COG3590	peptidase
GH913_19295	COG3590	peptidase
GH913_19315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GH913_19320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH913_19325	COG2311	Membrane
GH913_19330	COG1047	Peptidyl-prolyl cis-trans
GH913_19335	COG0791	NLP P60 protein
GH913_19340	COG0791	NLP P60 protein
GH913_19350	COG4106	trans-aconitate 2-methyltransferase activity
GH913_19355	COG1301	dicarboxylic acid transport
GH913_19360	COG1785	Belongs to the alkaline phosphatase family
GH913_19365	COG0037	tRNA processing
GH913_19370	COG1722	exodeoxyribonuclease VII activity
GH913_19375	COG0142	geranyltranstransferase activity
GH913_19385	COG4104	PAAR repeat-containing protein
GH913_19395	COG0312	modulator of DNA gyrase
GH913_19400	COG3028	Belongs to the UPF0307 family
GH913_19405	COG0312	modulator of DNA gyrase
GH913_19415	COG3164	Protein of unknown function
GH913_19420	COG1530	ribonuclease E activity
GH913_19425	COG0424	maF-like protein
GH913_19430	COG2968	Membrane
GH913_19445	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GH913_19460	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GH913_19475	COG0495	leucyl-tRNA aminoacylation
GH913_19485	COG3118	belongs to the thioredoxin family
GH913_19510	COG2155	Conserved Protein
GH913_19515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GH913_19560	COG1132	(ABC) transporter
GH913_19590	COG1538	Outer membrane efflux protein
GH913_19595	COG0745	RESPONSE REGULATOR receiver
GH913_19605	COG0475	glutathione-regulated potassium exporter activity
GH913_19610	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GH913_19615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GH913_19630	COG3706	GGDEF domain
GH913_19630	COG0745	RESPONSE REGULATOR receiver
GH913_19635	COG1187	pseudouridine synthase activity
GH913_19640	COG5002	protein histidine kinase activity
GH913_19640	COG5001	Diguanylate cyclase
GH913_19765	COG2814	Major facilitator Superfamily
GH913_19770	COG0583	DNA-binding transcription factor activity
GH913_19780	COG2207	Transcriptional regulator
GH913_19795	COG0667	Aldo Keto reductase
GH913_19800	COG1309	transcriptional regulator
GH913_19805	COG1538	Outer membrane efflux protein
GH913_19810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GH913_19825	COG0735	belongs to the Fur family
GH913_19830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GH913_19855	COG4452	Inner membrane protein CreD
GH913_19875	COG2205	protein histidine kinase activity
GH913_19880	COG0745	RESPONSE REGULATOR receiver
GH913_19885	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GH913_19895	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GH913_19930	COG2198	Histidine kinase
GH913_19930	COG0643	Histidine kinase
GH913_19935	COG0840	transmembrane signaling receptor activity
GH913_19940	COG0835	chemotaxis
GH913_19945	COG2200	EAL domain
GH913_19945	COG2199	diguanylate cyclase activity
GH913_19945	COG2202	Pas domain
GH913_19950	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GH913_19955	COG2201	protein-glutamate methylesterase activity
GH913_19960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GH913_19965	COG3590	peptidase
GH913_19975	COG0588	phosphoglycerate mutase activity
GH913_19980	COG1515	deoxyribonuclease V activity
GH913_19990	COG1741	Belongs to the pirin family
GH913_20005	COG1741	Belongs to the pirin family
GH913_20010	COG1966	Carbon starvation protein
GH913_20015	COG2879	small protein
GH913_20050	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GH913_20055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GH913_20060	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GH913_20065	COG2080	2 iron, 2 sulfur cluster binding
GH913_20070	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_20070	COG3321	synthase
GH913_20070	COG0604	alcohol dehydrogenase
GH913_20080	COG0629	single-stranded DNA binding
GH913_20085	COG0142	geranyltranstransferase activity
GH913_20100	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GH913_20115	COG0527	aspartate kinase activity
GH913_20120	COG0384	phenazine biosynthesis protein PhzF
GH913_20125	COG0384	phenazine biosynthesis protein PhzF
GH913_20135	COG1764	response to oxidative stress
GH913_20140	COG0540	Belongs to the ATCase OTCase family
GH913_20145	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GH913_20150	COG1678	Uncharacterized ACR, COG1678
GH913_20155	COG0519	Catalyzes the synthesis of GMP from XMP
GH913_20180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GH913_20195	COG0739	heme binding
GH913_20215	COG0693	protein deglycase activity
GH913_20225	COG1959	2 iron, 2 sulfur cluster binding
GH913_20230	COG0719	Fe-S assembly protein
GH913_20235	COG0396	ATPase activity
GH913_20240	COG0719	Fe-S assembly protein
GH913_20245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GH913_20260	COG4774	siderophore transport
GH913_20265	COG3128	pkhd-type hydroxylase
GH913_20290	COG1477	protein flavinylation
GH913_20295	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GH913_20310	COG1555	photosystem II stabilization
GH913_20325	COG3178	'Phosphotransferase
GH913_20330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GH913_20340	COG0628	permease
GH913_20350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GH913_20365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GH913_20385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GH913_20390	COG0271	Belongs to the BolA IbaG family
GH913_20400	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GH913_20410	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GH913_20415	COG1137	ATPase activity
GH913_20430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GH913_20435	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GH913_20440	COG1660	Displays ATPase and GTPase activities
GH913_20450	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GH913_20455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GH913_20460	COG2239	Acts as a magnesium transporter
GH913_20475	COG1294	oxidase, subunit
GH913_20480	COG1271	oxidase subunit
GH913_20490	COG1113	amino acid transport
GH913_20520	COG2197	response regulator
GH913_20525	COG0531	amino acid
GH913_20615	COG0754	glutathionylspermidine amidase activity
GH913_20640	COG1842	Phage shock protein A
GH913_20650	COG0259	pyridoxamine-phosphate oxidase activity
GH913_20655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GH913_20660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GH913_20670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GH913_20695	COG2198	Histidine kinase
GH913_20695	COG2205	protein histidine kinase activity
GH913_20695	COG0784	Response regulator, receiver
GH913_20700	COG2353	YceI-like domain
GH913_20720	COG1760	l-serine dehydratase
GH913_20730	COG0527	aspartate kinase activity
GH913_20730	COG0460	homoserine dehydrogenase
GH913_20735	COG0626	cystathionine gamma-synthase activity
GH913_20740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GH913_20745	COG0739	heme binding
GH913_20750	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GH913_20755	COG1272	protein, Hemolysin III
GH913_20760	COG2982	Protein involved in outer membrane biogenesis
GH913_20765	COG0516	GMP reductase activity
GH913_20765	COG0517	IMP dehydrogenase activity
GH913_20770	COG0463	Glycosyl transferase, family 2
GH913_20775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GH913_20780	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GH913_20790	COG4771	TonB-dependent receptor
GH913_20820	COG1309	transcriptional regulator
GH913_20825	COG2267	carboxylic ester hydrolase activity
GH913_20830	COG1960	acyl-CoA dehydrogenase activity
GH913_20860	COG0509	glycine decarboxylation via glycine cleavage system
GH913_20865	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GH913_20880	COG1742	UPF0060 membrane protein
GH913_20885	COG3956	TIGRFAM MazG family protein
GH913_20895	COG0494	nUDIX hydrolase
GH913_20905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GH913_20910	COG0837	glucose binding
GH913_20925	COG1388	LysM domain
GH913_20925	COG3858	chitin binding
GH913_20940	COG1472	Belongs to the glycosyl hydrolase 3 family
GH913_20995	COG3537	Alpha-1,2-mannosidase
GH913_21030	COG3142	Participates in the control of copper homeostasis
GH913_21035	COG1446	asparaginase
GH913_21060	COG0840	transmembrane signaling receptor activity
GH913_21065	COG0835	chemotaxis
GH913_21080	COG0189	ligase activity
GH913_21090	COG1397	ADP-ribosylglycohydrolase
GH913_21100	COG1199	ATP-dependent helicase activity
GH913_21110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GH913_21115	COG1215	transferase activity, transferring glycosyl groups
GH913_21125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GH913_21135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GH913_21140	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
GH913_21145	COG0535	radical SAM domain protein
GH913_21150	COG0535	radical SAM domain protein
GH913_21165	COG0837	glucose binding
GH913_21180	COG1643	Atp-dependent helicase
GH913_21185	COG0783	Belongs to the Dps family
GH913_21190	COG0514	ATP-dependent DNA helicase (RecQ)
GH913_21225	COG0840	transmembrane signaling receptor activity
GH913_21245	COG3920	Histidine kinase
GH913_21250	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GH913_21260	COG0602	queuosine metabolic process
GH913_21270	COG2885	chlorophyll binding
GH913_21275	COG0823	Involved in the tonB-independent uptake of proteins
GH913_21285	COG0848	biopolymer transport protein
GH913_21295	COG0824	Thioesterase
GH913_21300	COG2255	four-way junction helicase activity
GH913_21310	COG3158	transport of potassium into the cell
GH913_21315	COG0632	four-way junction helicase activity
GH913_21320	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GH913_21325	COG0217	transcriptional regulatory protein
GH913_21340	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GH913_21355	COG0477	Major facilitator Superfamily
GH913_21395	COG0488	(ABC) transporter
GH913_21425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GH913_21425	COG4651	solute:proton antiporter activity
GH913_21450	COG4772	TonB-dependent receptor
GH913_21460	COG4264	IucA IucC family
GH913_21475	COG0019	diaminopimelate decarboxylase activity
GH913_21495	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GH913_21505	COG1492	cobalamin metabolic process
GH913_21515	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GH913_21535	COG4206	TonB-dependent receptor
GH913_21540	COG0542	response to heat
GH913_21545	COG1116	anion transmembrane transporter activity
GH913_21550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GH913_21555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GH913_21560	COG0667	Aldo Keto reductase
GH913_21570	COG4771	TonB-dependent receptor
GH913_21575	COG2827	Endonuclease containing a URI domain
GH913_21615	COG1877	trehalose-phosphatase activity
GH913_21620	COG3387	PFAM Glycoside hydrolase 15-related
GH913_21635	COG0840	transmembrane signaling receptor activity
GH913_21640	COG3011	Protein conserved in bacteria
GH913_21655	COG0564	pseudouridine synthase activity
GH913_21660	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GH913_21670	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GH913_21670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GH913_21685	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GH913_21690	COG0045	succinate-CoA ligase (ADP-forming) activity
GH913_21715	COG4969	Belongs to the N-Me-Phe pilin family
GH913_21730	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GH913_21735	COG0237	dephospho-CoA kinase activity
GH913_21770	COG5002	protein histidine kinase activity
GH913_21775	COG0745	RESPONSE REGULATOR receiver
GH913_21785	COG0189	ligase activity
GH913_21900	COG1752	Esterase of the alpha-beta hydrolase superfamily
GH913_21925	COG2022	thiamine diphosphate biosynthetic process
GH913_21930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GH913_21935	COG0471	metal ion transport
GH913_21935	COG3273	potassium ion transport
GH913_21955	COG1970	mechanosensitive ion channel activity
GH913_21965	COG1609	Transcriptional regulator
GH913_21975	COG3250	beta-galactosidase activity
GH913_21980	COG4948	Mandelate Racemase Muconate Lactonizing
GH913_21995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GH913_22005	COG0308	aminopeptidase N
GH913_22030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GH913_22040	COG2895	sulfate adenylyltransferase (ATP) activity
GH913_22040	COG0529	Catalyzes the synthesis of activated sulfate
GH913_22045	COG0175	sulfate reduction
GH913_22050	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GH913_22055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GH913_22060	COG0175	sulfate reduction
GH913_22095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GH913_22095	COG1648	precorrin-2 dehydrogenase activity
GH913_22110	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GH913_22115	COG3588	fructose-bisphosphate aldolase
GH913_22120	COG0469	pyruvate kinase activity
GH913_22130	COG0126	phosphoglycerate kinase activity
GH913_22150	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GH913_22160	COG3047	cAMP biosynthetic process
GH913_22165	COG3047	cAMP biosynthetic process
GH913_22175	COG3453	Protein conserved in bacteria
GH913_22175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH913_22180	COG0725	ABC transporter, periplasmic molybdate-binding protein
GH913_22185	COG4149	molybdate abc transporter
GH913_22190	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GH913_22230	COG0739	heme binding
GH913_22240	COG4773	Receptor
GH913_22250	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GH913_22255	COG1301	dicarboxylic acid transport
GH913_22265	COG2304	oxidoreductase activity
GH913_22285	COG0714	Associated with various cellular activities
GH913_22315	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GH913_22330	COG0254	rRNA binding
GH913_22340	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GH913_22350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GH913_22355	COG1758	RNA polymerase activity
GH913_22360	COG0194	GDP metabolic process
GH913_22365	COG1561	YicC-like family, N-terminal region
GH913_22370	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GH913_22380	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GH913_22385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GH913_22400	COG0006	proline dipeptidase activity
GH913_22410	COG0006	proline dipeptidase activity
GH913_22415	COG3079	Belongs to the UPF0149 family
GH913_22435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GH913_22445	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GH913_22455	COG2912	Transglutaminase-like superfamily
GH913_22460	COG1773	rubredoxin
GH913_22465	COG0352	thiamine-phosphate diphosphorylase activity
GH913_22475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GH913_22490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GH913_22520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GH913_22525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GH913_22530	COG1028	Short-chain dehydrogenase reductase Sdr
GH913_22540	COG0671	phosphoesterase, PA-phosphatase related
GH913_22545	COG3781	membrane
GH913_22555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GH913_22560	COG0563	adenylate kinase activity
GH913_22580	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GH913_22590	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GH913_22610	COG3710	Transcriptional regulator
GH913_22615	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GH913_22625	COG0840	transmembrane signaling receptor activity
GH913_22630	COG0405	Gamma-glutamyltransferase
GH913_22635	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GH913_22725	COG1192	Involved in chromosome partitioning
GH913_22750	COG4644	lycopene metabolic process
GH913_22785	COG4456	Virulence-associated protein
GH913_22805	COG2951	lytic endotransglycosylase activity
GH913_22840	COG1192	Involved in chromosome partitioning
GH913_22950	COG1192	Involved in chromosome partitioning
GH913_23010	COG3318	Belongs to the UPF0149 family
GH913_23010	COG3012	SEC-C Motif Domain Protein
GH913_23030	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs