locus-tag	class	description
CIW72_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CIW72_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CIW72_00020	COG0187	DNA topoisomerase II activity
CIW72_00030	COG0501	Belongs to the peptidase M48B family
CIW72_00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CIW72_00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIW72_00115	COG0793	Belongs to the peptidase S41A family
CIW72_00120	COG4942	peptidase
CIW72_00130	COG2234	aminopeptidase activity
CIW72_00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CIW72_00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CIW72_00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CIW72_00170	COG1064	alcohol dehydrogenase
CIW72_00175	COG0493	'glutamate synthase
CIW72_00180	COG0067	glutamate synthase
CIW72_00180	COG0070	glutamate synthase
CIW72_00180	COG0069	glutamate synthase activity
CIW72_00230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CIW72_00245	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CIW72_00250	COG0438	transferase activity, transferring glycosyl groups
CIW72_00250	COG0297	glycogen (starch) synthase activity
CIW72_00270	COG0367	asparagine synthase
CIW72_00300	COG1132	(ABC) transporter
CIW72_00330	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CIW72_00425	COG1111	helicase
CIW72_00425	COG1205	dead DEAH box helicase
CIW72_00430	COG1272	protein, Hemolysin III
CIW72_00450	COG0300	oxidoreductase activity
CIW72_00455	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_00470	COG2249	NAD(P)H dehydrogenase (quinone) activity
CIW72_00500	COG3237	CsbD-like
CIW72_00550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIW72_00600	COG0714	Associated with various cellular activities
CIW72_00630	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CIW72_00640	COG4772	TonB-dependent receptor
CIW72_00705	COG1304	FMN binding
CIW72_00720	COG4585	Histidine kinase
CIW72_00725	COG2197	response regulator
CIW72_00745	COG3710	Transcriptional regulator
CIW72_00750	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CIW72_00805	COG0366	Alpha amylase catalytic
CIW72_00810	COG0366	Alpha amylase catalytic
CIW72_00815	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CIW72_00835	COG0657	acetylesterase activity
CIW72_00835	COG2755	lipolytic protein G-D-S-L family
CIW72_00845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CIW72_00860	COG3507	Belongs to the glycosyl hydrolase 43 family
CIW72_00865	COG1609	Transcriptional regulator
CIW72_00870	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CIW72_00875	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_00885	COG2755	lipolytic protein G-D-S-L family
CIW72_00900	COG3186	Phenylalanine-4-hydroxylase
CIW72_00905	COG1522	sequence-specific DNA binding
CIW72_00915	COG1752	Esterase of the alpha-beta hydrolase superfamily
CIW72_00925	COG1119	ATPase activity
CIW72_00940	COG1125	glycine betaine transport
CIW72_00955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CIW72_00975	COG1396	sequence-specific DNA binding
CIW72_01000	COG0489	protein tyrosine kinase activity
CIW72_01005	COG2062	phosphohistidine phosphatase, SixA
CIW72_01015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIW72_01045	COG1881	PFAM PEBP family protein
CIW72_01055	COG1968	undecaprenyl-diphosphatase activity
CIW72_01060	COG0174	glutamine synthetase
CIW72_01065	COG0347	Belongs to the P(II) protein family
CIW72_01070	COG0004	ammonium transporteR
CIW72_01075	COG3852	Histidine kinase
CIW72_01080	COG2204	response regulator
CIW72_01085	COG2032	superoxide dismutase activity
CIW72_01090	COG2032	superoxide dismutase activity
CIW72_01105	COG0183	Belongs to the thiolase family
CIW72_01140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CIW72_01145	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CIW72_01150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CIW72_01165	COG0028	Belongs to the TPP enzyme family
CIW72_01170	COG2205	protein histidine kinase activity
CIW72_01195	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CIW72_01210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CIW72_01220	COG0596	Alpha beta hydrolase
CIW72_01230	COG0318	PFAM AMP-dependent synthetase and ligase
CIW72_01240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CIW72_01255	COG1181	Belongs to the D-alanine--D-alanine ligase family
CIW72_01265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CIW72_01275	COG0564	pseudouridine synthase activity
CIW72_01295	COG1446	asparaginase
CIW72_01300	COG0339	signal peptide processing
CIW72_01330	COG0475	glutathione-regulated potassium exporter activity
CIW72_01340	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CIW72_01345	COG2224	Isocitrate lyase
CIW72_01350	COG3706	GGDEF domain
CIW72_01380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CIW72_01385	COG1960	acyl-CoA dehydrogenase activity
CIW72_01455	COG0697	spore germination
CIW72_01465	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CIW72_01470	COG1846	Transcriptional regulator
CIW72_01475	COG1764	response to oxidative stress
CIW72_01505	COG2130	NADP-dependent
CIW72_01520	COG1187	pseudouridine synthase activity
CIW72_01535	COG1643	Atp-dependent helicase
CIW72_01545	COG4807	Protein conserved in bacteria
CIW72_01550	COG2351	hydroxyisourate hydrolase activity
CIW72_01555	COG2072	flavoprotein involved in K transport
CIW72_01575	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CIW72_01610	COG1957	nucleoside hydrolase
CIW72_01620	COG2252	PERMEase
CIW72_01645	COG0084	hydrolase, TatD family'
CIW72_01660	COG0583	DNA-binding transcription factor activity
CIW72_01665	COG2814	Major facilitator Superfamily
CIW72_01680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CIW72_01685	COG1902	pentaerythritol trinitrate reductase activity
CIW72_01705	COG0745	RESPONSE REGULATOR receiver
CIW72_01710	COG2205	protein histidine kinase activity
CIW72_01715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIW72_01725	COG1538	Outer membrane efflux protein
CIW72_01740	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CIW72_01745	COG0583	DNA-binding transcription factor activity
CIW72_01780	COG0702	epimerase
CIW72_01785	COG1733	regulation of RNA biosynthetic process
CIW72_01840	COG0129	dihydroxy-acid dehydratase activity
CIW72_01855	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CIW72_01910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CIW72_01915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CIW72_01940	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CIW72_01945	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CIW72_01960	COG3485	protocatechuate 3,4-dioxygenase
CIW72_01970	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CIW72_01975	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CIW72_01985	COG1414	Transcriptional regulator
CIW72_02005	COG0445	tRNA wobble uridine modification
CIW72_02045	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_02050	COG2267	carboxylic ester hydrolase activity
CIW72_02060	COG0156	8-amino-7-oxononanoate synthase activity
CIW72_02065	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CIW72_02070	COG1040	competence protein
CIW72_02075	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CIW72_02155	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CIW72_02225	COG3264	Mechanosensitive ion channel
CIW72_02225	COG1511	domain protein
CIW72_02230	COG1368	sulfuric ester hydrolase activity
CIW72_02240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CIW72_02245	COG2354	Protein conserved in bacteria
CIW72_02250	COG3706	GGDEF domain
CIW72_02250	COG0745	RESPONSE REGULATOR receiver
CIW72_02255	COG0297	glycogen (starch) synthase activity
CIW72_02260	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CIW72_02265	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CIW72_02290	COG0702	epimerase
CIW72_02295	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_02335	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_02345	COG0513	Belongs to the DEAD box helicase family
CIW72_02350	COG0508	dehydrogenase complex catalyzes the overall conversion of
CIW72_02365	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CIW72_02375	COG3483	tryptophan 2,3-dioxygenase activity
CIW72_02380	COG3104	oligopeptide transport
CIW72_02400	COG2852	Protein conserved in bacteria
CIW72_02405	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CIW72_02425	COG1320	monovalent cation:proton antiporter activity
CIW72_02430	COG2212	antiporter activity
CIW72_02440	COG0651	ATP synthesis coupled electron transport
CIW72_02445	COG1006	Multisubunit Na H antiporter MnhC subunit
CIW72_02450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CIW72_02450	COG2111	Na H antiporter
CIW72_02470	COG3179	chitinase
CIW72_02490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CIW72_02495	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CIW72_02510	COG0456	acetyltransferase
CIW72_02515	COG0582	viral genome integration into host DNA
CIW72_02605	COG1597	lipid kinase activity
CIW72_02630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CIW72_02635	COG0134	indole-3-glycerol-phosphate synthase activity
CIW72_02645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CIW72_02650	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CIW72_02665	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CIW72_02670	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CIW72_02675	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CIW72_02690	COG1051	belongs to the nudix hydrolase family
CIW72_02730	COG0316	Belongs to the HesB IscA family
CIW72_02750	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CIW72_02770	COG2814	Major facilitator Superfamily
CIW72_02780	COG2814	Major facilitator Superfamily
CIW72_02785	COG1289	transmembrane transporter activity
CIW72_02795	COG0151	Belongs to the GarS family
CIW72_02805	COG0138	bifunctional purine biosynthesis protein purh
CIW72_02810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CIW72_02815	COG2267	carboxylic ester hydrolase activity
CIW72_02820	COG2453	phosphatase
CIW72_02820	COG0671	phosphoesterase, PA-phosphatase related
CIW72_02850	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CIW72_02875	COG2264	protein methyltransferase activity
CIW72_02895	COG0439	Biotin carboxylase
CIW72_02905	COG0511	ligase activity, forming carbon-carbon bonds
CIW72_02910	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CIW72_02920	COG1324	tolerance protein
CIW72_02950	COG0300	oxidoreductase activity
CIW72_02955	COG2356	endonuclease I
CIW72_02965	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CIW72_02970	COG0459	protein refolding
CIW72_02985	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CIW72_03000	COG3386	PFAM SMP-30 Gluconolaconase
CIW72_03010	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CIW72_03015	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CIW72_03035	COG0778	Nitroreductase
CIW72_03040	COG2353	YceI-like domain
CIW72_03070	COG3052	prosthetic group binding
CIW72_03090	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CIW72_03095	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CIW72_03105	COG1802	Transcriptional regulator
CIW72_03110	COG0546	phosphoglycolate phosphatase activity
CIW72_03150	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CIW72_03195	COG4221	oxidoreductase activity
CIW72_03205	COG0435	Glutathione S-transferase
CIW72_03230	COG2409	Drug exporters of the RND superfamily
CIW72_03240	COG0823	Involved in the tonB-independent uptake of proteins
CIW72_03240	COG1506	peptidase
CIW72_03255	COG3706	GGDEF domain
CIW72_03280	COG0697	spore germination
CIW72_03295	COG1113	amino acid transport
CIW72_03305	COG0598	Magnesium transport protein CorA
CIW72_03315	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CIW72_03360	COG5001	Diguanylate cyclase
CIW72_03365	COG0840	transmembrane signaling receptor activity
CIW72_03370	COG5297	Belongs to the glycosyl hydrolase family 6
CIW72_03370	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CIW72_03375	COG0659	secondary active sulfate transmembrane transporter activity
CIW72_03380	COG3706	GGDEF domain
CIW72_03400	COG2943	transferase activity, transferring hexosyl groups
CIW72_03410	COG3275	phosphorelay sensor kinase activity
CIW72_03420	COG0181	hydroxymethylbilane synthase activity
CIW72_03450	COG1505	serine-type exopeptidase activity
CIW72_03460	COG0436	Aminotransferase
CIW72_03470	COG2832	Protein of unknown function (DUF454)
CIW72_03480	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CIW72_03490	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CIW72_03495	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CIW72_03500	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CIW72_03525	COG2226	methyltransferase
CIW72_03530	COG2199	diguanylate cyclase activity
CIW72_03535	COG0308	aminopeptidase N
CIW72_03575	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CIW72_03585	COG3284	Transcriptional regulator
CIW72_03595	COG1077	Cell shape determining protein MreB Mrl
CIW72_03600	COG1792	Involved in formation and maintenance of cell shape
CIW72_03615	COG0772	Belongs to the SEDS family
CIW72_03625	COG2951	lytic endotransglycosylase activity
CIW72_03630	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CIW72_03640	COG1686	Belongs to the peptidase S11 family
CIW72_03650	COG2921	Belongs to the UPF0250 family
CIW72_03655	COG0321	lipoyl(octanoyl) transferase activity
CIW72_03660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CIW72_03675	COG0583	DNA-binding transcription factor activity
CIW72_03685	COG1056	cytidyltransferase-related domain
CIW72_03685	COG1051	belongs to the nudix hydrolase family
CIW72_03720	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CIW72_03725	COG0673	inositol 2-dehydrogenase activity
CIW72_03730	COG2823	Periplasmic or secreted lipoprotein
CIW72_03735	COG4251	negative regulation of phosphorylation
CIW72_03740	COG0784	Response regulator, receiver
CIW72_03745	COG4191	Histidine kinase
CIW72_03750	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CIW72_03810	COG1459	type II secretion system
CIW72_03830	COG4795	General secretion pathway protein
CIW72_03860	COG3250	beta-galactosidase activity
CIW72_03885	COG1609	Transcriptional regulator
CIW72_03890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CIW72_03895	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CIW72_03905	COG0617	tRNA 3'-terminal CCA addition
CIW72_03910	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CIW72_03915	COG1012	belongs to the aldehyde dehydrogenase family
CIW72_03920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CIW72_03935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CIW72_03950	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CIW72_03955	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CIW72_03975	COG2205	protein histidine kinase activity
CIW72_03980	COG0745	RESPONSE REGULATOR receiver
CIW72_04005	COG3791	Glutathione-dependent formaldehyde-activating
CIW72_04020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIW72_04030	COG0697	spore germination
CIW72_04040	COG0488	(ABC) transporter
CIW72_04050	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CIW72_04055	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CIW72_04065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CIW72_04065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CIW72_04085	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CIW72_04090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CIW72_04095	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CIW72_04120	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CIW72_04125	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CIW72_04130	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CIW72_04135	COG2205	protein histidine kinase activity
CIW72_04140	COG0745	RESPONSE REGULATOR receiver
CIW72_04155	COG0277	FAD linked oxidase domain protein
CIW72_04160	COG1988	membrane-bound metal-dependent
CIW72_04165	COG0792	nuclease activity
CIW72_04200	COG2001	Belongs to the MraZ family
CIW72_04205	COG0275	rRNA processing
CIW72_04210	COG3116	cell division
CIW72_04220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CIW72_04225	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CIW72_04230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CIW72_04240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CIW72_04245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CIW72_04250	COG1181	Belongs to the D-alanine--D-alanine ligase family
CIW72_04255	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CIW72_04270	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CIW72_04280	COG0739	heme binding
CIW72_04285	COG0653	protein targeting
CIW72_04290	COG0494	nUDIX hydrolase
CIW72_04300	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CIW72_04315	COG3321	synthase
CIW72_04315	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_04315	COG0604	alcohol dehydrogenase
CIW72_04340	COG0366	Alpha amylase catalytic
CIW72_04370	COG2226	methyltransferase
CIW72_04375	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CIW72_04385	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CIW72_04425	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CIW72_04435	COG4106	trans-aconitate 2-methyltransferase activity
CIW72_04440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CIW72_04450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIW72_04455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CIW72_04465	COG0667	Aldo Keto reductase
CIW72_04475	COG4771	TonB-dependent receptor
CIW72_04495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CIW72_04500	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CIW72_04510	COG2175	clavaminate synthase activity
CIW72_04520	COG4181	ATPase activity
CIW72_04535	COG0642	Histidine kinase
CIW72_04550	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CIW72_04570	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CIW72_04575	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CIW72_04590	COG3829	transcription factor binding
CIW72_04600	COG1116	anion transmembrane transporter activity
CIW72_04605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CIW72_04615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIW72_04620	COG0431	NADPH-dependent FMN reductase
CIW72_04645	COG0747	negative chemotaxis
CIW72_04665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CIW72_04670	COG2967	ApaG domain
CIW72_04675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CIW72_04680	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CIW72_04685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CIW72_04690	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CIW72_04705	COG0123	including yeast histone deacetylase and acetoin utilization protein
CIW72_04710	COG2096	Adenosyltransferase
CIW72_04725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CIW72_04730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CIW72_04765	COG3384	dioxygenase
CIW72_04770	COG0583	DNA-binding transcription factor activity
CIW72_04775	COG0318	PFAM AMP-dependent synthetase and ligase
CIW72_04785	COG1024	Enoyl-CoA hydratase
CIW72_04805	COG3386	PFAM SMP-30 Gluconolaconase
CIW72_04845	COG0697	spore germination
CIW72_04855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CIW72_04870	COG3706	GGDEF domain
CIW72_04870	COG0745	RESPONSE REGULATOR receiver
CIW72_04880	COG2197	response regulator
CIW72_04890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CIW72_04900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CIW72_04905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CIW72_04915	COG0583	DNA-binding transcription factor activity
CIW72_04920	COG3634	alkyl hydroperoxide reductase activity
CIW72_04930	COG2890	protein-(glutamine-N5) methyltransferase activity
CIW72_04950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CIW72_04950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CIW72_04980	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CIW72_05000	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CIW72_05005	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CIW72_05020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CIW72_05035	COG1404	Belongs to the peptidase S8 family
CIW72_05040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CIW72_05065	COG1295	ribonuclease BN
CIW72_05070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIW72_05075	COG1254	Belongs to the acylphosphatase family
CIW72_05090	COG0521	Mo-molybdopterin cofactor biosynthetic process
CIW72_05100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CIW72_05105	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CIW72_05115	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CIW72_05120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CIW72_05130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CIW72_05135	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CIW72_05140	COG0193	aminoacyl-tRNA hydrolase activity
CIW72_05145	COG0012	GTP binding
CIW72_05165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CIW72_05175	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CIW72_05180	COG0250	Participates in transcription elongation, termination and antitermination
CIW72_05185	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CIW72_05190	COG0081	regulation of translation
CIW72_05195	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CIW72_05200	COG0222	ribosome binding
CIW72_05205	COG0085	RNA polymerase activity
CIW72_05210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CIW72_05215	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CIW72_05220	COG0049	tRNA binding
CIW72_05225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CIW72_05230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CIW72_05235	COG0051	transcription antitermination factor activity, RNA binding
CIW72_05240	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CIW72_05245	COG0088	Forms part of the polypeptide exit tunnel
CIW72_05250	COG0089	rRNA binding
CIW72_05255	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CIW72_05260	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CIW72_05265	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CIW72_05270	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CIW72_05275	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CIW72_05280	COG0255	Belongs to the universal ribosomal protein uL29 family
CIW72_05285	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CIW72_05290	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CIW72_05295	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CIW72_05300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CIW72_05305	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CIW72_05310	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CIW72_05315	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CIW72_05320	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CIW72_05325	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CIW72_05330	COG1841	ribosomal large subunit assembly
CIW72_05335	COG0200	Binds to the 23S rRNA
CIW72_05340	COG0201	protein transport
CIW72_05345	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CIW72_05350	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CIW72_05355	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CIW72_05360	COG0202	RNA polymerase activity
CIW72_05365	COG0203	ribosomal protein L17
CIW72_05370	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CIW72_05390	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CIW72_05400	COG0154	amidase activity
CIW72_05415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CIW72_05420	COG0039	L-malate dehydrogenase activity
CIW72_05455	COG1902	pentaerythritol trinitrate reductase activity
CIW72_05455	COG0446	pyridine nucleotide-disulphide oxidoreductase
CIW72_05460	COG0604	alcohol dehydrogenase
CIW72_05490	COG0156	8-amino-7-oxononanoate synthase activity
CIW72_05495	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CIW72_05500	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CIW72_05505	COG4208	sulfate ABC transporter
CIW72_05510	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CIW72_05520	COG1063	alcohol dehydrogenase
CIW72_05550	COG0406	alpha-ribazole phosphatase activity
CIW72_05555	COG0285	dihydrofolate synthase activity
CIW72_05575	COG2833	Protein of unknown function (DUF455)
CIW72_05585	COG3291	Pkd domain containing protein
CIW72_05595	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CIW72_05600	COG0671	phosphoesterase, PA-phosphatase related
CIW72_05605	COG0438	transferase activity, transferring glycosyl groups
CIW72_05615	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CIW72_05630	COG4783	chaperone-mediated protein folding
CIW72_05645	COG0473	3-isopropylmalate dehydrogenase activity
CIW72_05715	COG3179	chitinase
CIW72_05775	COG0189	ligase activity
CIW72_05785	COG0745	RESPONSE REGULATOR receiver
CIW72_05790	COG5002	protein histidine kinase activity
CIW72_05820	COG0237	dephospho-CoA kinase activity
CIW72_05825	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CIW72_05890	COG0045	succinate-CoA ligase (ADP-forming) activity
CIW72_05910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CIW72_05910	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CIW72_05920	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CIW72_05925	COG0564	pseudouridine synthase activity
CIW72_05940	COG3011	Protein conserved in bacteria
CIW72_05945	COG0840	transmembrane signaling receptor activity
CIW72_05965	COG3387	PFAM Glycoside hydrolase 15-related
CIW72_05970	COG1877	trehalose-phosphatase activity
CIW72_06010	COG2827	Endonuclease containing a URI domain
CIW72_06015	COG4771	TonB-dependent receptor
CIW72_06040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CIW72_06045	COG1116	anion transmembrane transporter activity
CIW72_06050	COG0542	response to heat
CIW72_06055	COG4206	TonB-dependent receptor
CIW72_06075	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CIW72_06085	COG1492	cobalamin metabolic process
CIW72_06095	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CIW72_06115	COG0019	diaminopimelate decarboxylase activity
CIW72_06130	COG4264	IucA IucC family
CIW72_06140	COG4772	TonB-dependent receptor
CIW72_06165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CIW72_06165	COG4651	solute:proton antiporter activity
CIW72_06205	COG0488	(ABC) transporter
CIW72_06250	COG0477	Major facilitator Superfamily
CIW72_06265	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CIW72_06280	COG0217	transcriptional regulatory protein
CIW72_06285	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CIW72_06290	COG0632	four-way junction helicase activity
CIW72_06295	COG3158	transport of potassium into the cell
CIW72_06305	COG2255	four-way junction helicase activity
CIW72_06310	COG0824	Thioesterase
CIW72_06320	COG0848	biopolymer transport protein
CIW72_06330	COG0823	Involved in the tonB-independent uptake of proteins
CIW72_06335	COG2885	chlorophyll binding
CIW72_06345	COG0602	queuosine metabolic process
CIW72_06355	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CIW72_06360	COG3920	Histidine kinase
CIW72_06380	COG0840	transmembrane signaling receptor activity
CIW72_06415	COG0514	ATP-dependent DNA helicase (RecQ)
CIW72_06425	COG0783	Belongs to the Dps family
CIW72_06430	COG1643	Atp-dependent helicase
CIW72_06445	COG0837	glucose binding
CIW72_06460	COG0535	radical SAM domain protein
CIW72_06465	COG0535	radical SAM domain protein
CIW72_06470	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CIW72_06475	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CIW72_06485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CIW72_06500	COG1215	transferase activity, transferring glycosyl groups
CIW72_06505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CIW72_06515	COG1199	ATP-dependent helicase activity
CIW72_06520	COG1214	PFAM Peptidase M22, glycoprotease
CIW72_06525	COG1397	ADP-ribosylglycohydrolase
CIW72_06535	COG0189	ligase activity
CIW72_06550	COG0835	chemotaxis
CIW72_06555	COG0840	transmembrane signaling receptor activity
CIW72_06595	COG1446	asparaginase
CIW72_06600	COG3142	Participates in the control of copper homeostasis
CIW72_06640	COG3537	Alpha-1,2-mannosidase
CIW72_06670	COG1472	Belongs to the glycosyl hydrolase 3 family
CIW72_06685	COG3858	chitin binding
CIW72_06685	COG1388	LysM domain
CIW72_06700	COG0837	glucose binding
CIW72_06705	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CIW72_06715	COG0494	nUDIX hydrolase
CIW72_06725	COG3956	TIGRFAM MazG family protein
CIW72_06730	COG1742	UPF0060 membrane protein
CIW72_06745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CIW72_06750	COG0509	glycine decarboxylation via glycine cleavage system
CIW72_06775	COG1960	acyl-CoA dehydrogenase activity
CIW72_06780	COG2267	carboxylic ester hydrolase activity
CIW72_06785	COG1309	transcriptional regulator
CIW72_06805	COG4771	TonB-dependent receptor
CIW72_06815	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CIW72_06820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CIW72_06825	COG0463	Glycosyl transferase, family 2
CIW72_06830	COG0516	GMP reductase activity
CIW72_06830	COG0517	IMP dehydrogenase activity
CIW72_06835	COG2982	Protein involved in outer membrane biogenesis
CIW72_06840	COG1272	protein, Hemolysin III
CIW72_06845	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CIW72_06850	COG0739	heme binding
CIW72_06855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CIW72_06860	COG0626	cystathionine gamma-synthase activity
CIW72_06865	COG0527	aspartate kinase activity
CIW72_06865	COG0460	homoserine dehydrogenase
CIW72_06880	COG1760	l-serine dehydratase
CIW72_06900	COG2353	YceI-like domain
CIW72_06905	COG0784	Response regulator, receiver
CIW72_06905	COG2205	protein histidine kinase activity
CIW72_06905	COG2198	Histidine kinase
CIW72_06925	COG0477	Major facilitator Superfamily
CIW72_06930	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CIW72_06940	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CIW72_06945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CIW72_06950	COG0259	pyridoxamine-phosphate oxidase activity
CIW72_06960	COG1842	Phage shock protein A
CIW72_06985	COG0754	glutathionylspermidine amidase activity
CIW72_06995	COG2814	Major facilitator Superfamily
CIW72_07075	COG0531	amino acid
CIW72_07080	COG2197	response regulator
CIW72_07110	COG1113	amino acid transport
CIW72_07120	COG1271	oxidase subunit
CIW72_07125	COG1294	oxidase, subunit
CIW72_07140	COG2239	Acts as a magnesium transporter
CIW72_07150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CIW72_07155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CIW72_07165	COG1660	Displays ATPase and GTPase activities
CIW72_07170	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CIW72_07175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CIW72_07190	COG1137	ATPase activity
CIW72_07195	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CIW72_07205	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CIW72_07215	COG0271	Belongs to the BolA IbaG family
CIW72_07220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CIW72_07240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CIW72_07255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CIW72_07265	COG0628	permease
CIW72_07275	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CIW72_07295	COG1555	photosystem II stabilization
CIW72_07310	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CIW72_07315	COG1477	protein flavinylation
CIW72_07340	COG3128	pkhd-type hydroxylase
CIW72_07345	COG4774	siderophore transport
CIW72_07360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CIW72_07365	COG0719	Fe-S assembly protein
CIW72_07370	COG0396	ATPase activity
CIW72_07375	COG0719	Fe-S assembly protein
CIW72_07380	COG1959	2 iron, 2 sulfur cluster binding
CIW72_07390	COG0693	protein deglycase activity
CIW72_07410	COG0739	heme binding
CIW72_07425	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CIW72_07460	COG1678	Uncharacterized ACR, COG1678
CIW72_07465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CIW72_07470	COG0540	Belongs to the ATCase OTCase family
CIW72_07475	COG1764	response to oxidative stress
CIW72_07485	COG0384	phenazine biosynthesis protein PhzF
CIW72_07490	COG0384	phenazine biosynthesis protein PhzF
CIW72_07495	COG0527	aspartate kinase activity
CIW72_07510	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CIW72_07525	COG0142	geranyltranstransferase activity
CIW72_07530	COG0629	single-stranded DNA binding
CIW72_07535	COG2203	Gaf domain
CIW72_07535	COG3706	GGDEF domain
CIW72_07535	COG4251	negative regulation of phosphorylation
CIW72_07535	COG5001	Diguanylate cyclase
CIW72_07540	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_07540	COG3321	synthase
CIW72_07540	COG0604	alcohol dehydrogenase
CIW72_07545	COG2080	2 iron, 2 sulfur cluster binding
CIW72_07550	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CIW72_07555	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CIW72_07560	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CIW72_07605	COG2879	small protein
CIW72_07610	COG1966	Carbon starvation protein
CIW72_07615	COG1741	Belongs to the pirin family
CIW72_07630	COG1741	Belongs to the pirin family
CIW72_07640	COG1515	deoxyribonuclease V activity
CIW72_07645	COG0588	phosphoglycerate mutase activity
CIW72_07660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIW72_07665	COG2201	protein-glutamate methylesterase activity
CIW72_07670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CIW72_07675	COG2199	diguanylate cyclase activity
CIW72_07675	COG2200	EAL domain
CIW72_07675	COG2202	Pas domain
CIW72_07680	COG0835	chemotaxis
CIW72_07685	COG0840	transmembrane signaling receptor activity
CIW72_07690	COG2198	Histidine kinase
CIW72_07690	COG0643	Histidine kinase
CIW72_07735	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CIW72_07745	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CIW72_07750	COG0745	RESPONSE REGULATOR receiver
CIW72_07755	COG2205	protein histidine kinase activity
CIW72_07765	COG4452	Inner membrane protein CreD
CIW72_07790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CIW72_07795	COG0735	belongs to the Fur family
CIW72_07810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIW72_07815	COG1538	Outer membrane efflux protein
CIW72_07820	COG1309	transcriptional regulator
CIW72_07825	COG0667	Aldo Keto reductase
CIW72_07840	COG2207	Transcriptional regulator
CIW72_07850	COG0583	DNA-binding transcription factor activity
CIW72_07855	COG2814	Major facilitator Superfamily
CIW72_07980	COG5002	protein histidine kinase activity
CIW72_07980	COG5001	Diguanylate cyclase
CIW72_07985	COG1187	pseudouridine synthase activity
CIW72_07990	COG3706	GGDEF domain
CIW72_07990	COG0745	RESPONSE REGULATOR receiver
CIW72_08010	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CIW72_08020	COG0475	glutathione-regulated potassium exporter activity
CIW72_08030	COG0745	RESPONSE REGULATOR receiver
CIW72_08035	COG1538	Outer membrane efflux protein
CIW72_08065	COG1132	(ABC) transporter
CIW72_08105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CIW72_08110	COG2155	Conserved Protein
CIW72_08135	COG3118	belongs to the thioredoxin family
CIW72_08145	COG0495	leucyl-tRNA aminoacylation
CIW72_08160	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CIW72_08175	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CIW72_08190	COG2968	Membrane
CIW72_08195	COG0424	maF-like protein
CIW72_08200	COG1530	ribonuclease E activity
CIW72_08205	COG3164	Protein of unknown function
CIW72_08215	COG0312	modulator of DNA gyrase
CIW72_08220	COG3028	Belongs to the UPF0307 family
CIW72_08225	COG0312	modulator of DNA gyrase
CIW72_08235	COG4104	PAAR repeat-containing protein
CIW72_08240	COG0142	geranyltranstransferase activity
CIW72_08245	COG1722	exodeoxyribonuclease VII activity
CIW72_08250	COG0037	tRNA processing
CIW72_08260	COG1785	Belongs to the alkaline phosphatase family
CIW72_08265	COG1301	dicarboxylic acid transport
CIW72_08270	COG4106	trans-aconitate 2-methyltransferase activity
CIW72_08280	COG0791	NLP P60 protein
CIW72_08285	COG0791	NLP P60 protein
CIW72_08290	COG1047	Peptidyl-prolyl cis-trans
CIW72_08295	COG2311	Membrane
CIW72_08300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CIW72_08305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CIW72_08325	COG3590	peptidase
CIW72_08335	COG3590	peptidase
CIW72_08355	COG0489	protein tyrosine kinase activity
CIW72_08365	COG0717	Belongs to the dCTP deaminase family
CIW72_08410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CIW72_08430	COG0494	nUDIX hydrolase
CIW72_08435	COG0433	COG0433 Predicted ATPase
CIW72_08450	COG0688	phosphatidylethanolamine metabolic process
CIW72_08460	COG2890	protein-(glutamine-N5) methyltransferase activity
CIW72_08465	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CIW72_08470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CIW72_08475	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CIW72_08495	COG0101	tRNA pseudouridine synthase activity
CIW72_08500	COG0135	phosphoribosylanthranilate isomerase activity
CIW72_08510	COG0133	tryptophan synthase activity
CIW72_08520	COG0159	tryptophan synthase activity
CIW72_08525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CIW72_08530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CIW72_08560	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_08565	COG0149	triose-phosphate isomerase activity
CIW72_08580	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIW72_08585	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIW72_08590	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIW72_08595	COG0649	NAD binding
CIW72_08600	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CIW72_08605	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CIW72_08615	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CIW72_08620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIW72_08630	COG0713	ATP synthesis coupled electron transport
CIW72_08645	COG1007	ATP synthesis coupled electron transport
CIW72_08655	COG0779	Required for maturation of 30S ribosomal subunits
CIW72_08660	COG0195	Participates in both transcription termination and antitermination
CIW72_08665	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CIW72_08670	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CIW72_08675	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CIW72_08680	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CIW72_08685	COG1185	polyribonucleotide nucleotidyltransferase activity
CIW72_08715	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CIW72_08720	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CIW72_08730	COG2095	MarC family integral membrane protein
CIW72_08745	COG1611	Belongs to the LOG family
CIW72_08790	COG0556	nucleotide-excision repair
CIW72_08810	COG3505	Type IV secretory pathway VirD4
CIW72_08830	COG2948	multi-organism process
CIW72_08850	COG3702	type iv secretory pathway
CIW72_08895	COG0366	Alpha amylase catalytic
CIW72_08910	COG1082	Xylose isomerase domain protein TIM barrel
CIW72_08935	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CIW72_08940	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CIW72_08945	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CIW72_08950	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CIW72_08955	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CIW72_08960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CIW72_08960	COG0072	phenylalanine-tRNA ligase activity
CIW72_08965	COG0776	regulation of translation
CIW72_09010	COG0438	transferase activity, transferring glycosyl groups
CIW72_09015	COG0438	transferase activity, transferring glycosyl groups
CIW72_09050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CIW72_09055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIW72_09060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CIW72_09080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CIW72_09090	COG1960	acyl-CoA dehydrogenase activity
CIW72_09105	COG3040	lipid binding
CIW72_09120	COG0322	excinuclease ABC activity
CIW72_09140	COG4191	Histidine kinase
CIW72_09140	COG0784	Response regulator, receiver
CIW72_09145	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CIW72_09150	COG1194	a g-specific adenine glycosylase
CIW72_09160	COG0552	protein localization to endoplasmic reticulum
CIW72_09170	COG3938	Belongs to the proline racemase family
CIW72_09175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CIW72_09190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CIW72_09200	COG0006	proline dipeptidase activity
CIW72_09215	COG0531	amino acid
CIW72_09280	COG4206	TonB-dependent receptor
CIW72_09310	COG0326	Molecular chaperone. Has ATPase activity
CIW72_09315	COG0742	ribosomal rna small subunit methyltransferase
CIW72_09320	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CIW72_09335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CIW72_09340	COG0405	Gamma-glutamyltransferase
CIW72_09345	COG3291	Pkd domain containing protein
CIW72_09350	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CIW72_09390	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CIW72_09395	COG0343	queuine tRNA-ribosyltransferase activity
CIW72_09400	COG1862	Preprotein translocase
CIW72_09410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CIW72_09435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CIW72_09435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CIW72_09440	COG1105	Belongs to the carbohydrate kinase PfkB family
CIW72_09445	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CIW72_09445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CIW72_09450	COG1609	Transcriptional regulator
CIW72_09455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIW72_09460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIW72_09470	COG2902	Dehydrogenase
CIW72_09495	COG0784	Response regulator, receiver
CIW72_09495	COG5002	protein histidine kinase activity
CIW72_09495	COG2205	protein histidine kinase activity
CIW72_09500	COG2733	membrane
CIW72_09530	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CIW72_09535	COG0243	molybdopterin cofactor binding
CIW72_09545	COG0477	Major facilitator Superfamily
CIW72_09550	COG2703	oxygen carrier activity
CIW72_09555	COG3706	GGDEF domain
CIW72_09555	COG0745	RESPONSE REGULATOR receiver
CIW72_09565	COG0174	glutamine synthetase
CIW72_09570	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CIW72_09585	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CIW72_09605	COG3842	ATPase activity
CIW72_09610	COG1176	ABC-type spermidine putrescine transport system, permease component I
CIW72_09615	COG1177	transmembrane transport
CIW72_09620	COG1012	belongs to the aldehyde dehydrogenase family
CIW72_09635	COG4535	Mg2 and Co2 transporter CorC
CIW72_09645	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CIW72_09655	COG1702	phosphate starvation-inducible protein PhoH
CIW72_09660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CIW72_09675	COG0741	lytic transglycosylase activity
CIW72_09685	COG0723	plastoquinol--plastocyanin reductase activity
CIW72_09690	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CIW72_09695	COG2857	Cytochrome c1
CIW72_09700	COG0625	glutathione transferase activity
CIW72_09705	COG2969	positive regulation of protein catabolic process
CIW72_09725	COG1201	RNA secondary structure unwinding
CIW72_09730	COG2094	Belongs to the DNA glycosylase MPG family
CIW72_09735	COG0840	transmembrane signaling receptor activity
CIW72_09795	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CIW72_09805	COG1570	exodeoxyribonuclease VII activity
CIW72_09810	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CIW72_09815	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CIW72_09815	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CIW72_09820	COG0802	atpase or kinase
CIW72_09825	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIW72_09830	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CIW72_09855	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_09860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CIW72_09865	COG0501	Belongs to the peptidase M48B family
CIW72_09875	COG2081	HI0933 family
CIW72_09880	COG4681	YaeQ
CIW72_09890	COG0625	glutathione transferase activity
CIW72_09900	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CIW72_09905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CIW72_09910	COG0513	Belongs to the DEAD box helicase family
CIW72_09940	COG0483	inositol monophosphate 1-phosphatase activity
CIW72_09955	COG3300	MHYT domain
CIW72_09955	COG5001	Diguanylate cyclase
CIW72_09960	COG1509	lysine 2,3-aminomutase activity
CIW72_09965	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CIW72_09975	COG0402	S-adenosylhomocysteine deaminase activity
CIW72_09980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CIW72_10045	COG4302	ethanolamine ammonia-lyase activity
CIW72_10075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CIW72_10080	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CIW72_10085	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CIW72_10095	COG2166	iron-sulfur cluster assembly
CIW72_10100	COG0215	cysteine-tRNA ligase activity
CIW72_10110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CIW72_10115	COG0137	argininosuccinate synthase activity
CIW72_10130	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CIW72_10140	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CIW72_10145	COG0165	Argininosuccinate lyase
CIW72_10155	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CIW72_10160	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CIW72_10190	COG1294	oxidase, subunit
CIW72_10200	COG4988	ABC transporter
CIW72_10205	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CIW72_10210	COG1278	Cold shock
CIW72_10215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CIW72_10235	COG1138	Cytochrome C-type biogenesis protein
CIW72_10240	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CIW72_10260	COG4133	protoheme IX ABC transporter activity
CIW72_10265	COG0436	Aminotransferase
CIW72_10285	COG1187	pseudouridine synthase activity
CIW72_10290	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CIW72_10295	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CIW72_10300	COG2350	Protein conserved in bacteria
CIW72_10330	COG1175	transmembrane transport
CIW72_10335	COG0395	ABC-type sugar transport system, permease component
CIW72_10360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CIW72_10365	COG2957	Belongs to the agmatine deiminase family
CIW72_10380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CIW72_10385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CIW72_10390	COG0539	negative regulation of cytoplasmic translation
CIW72_10395	COG0776	regulation of translation
CIW72_10405	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CIW72_10410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CIW72_10420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CIW72_10425	COG0475	glutathione-regulated potassium exporter activity
CIW72_10425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CIW72_10435	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CIW72_10445	COG0519	Catalyzes the synthesis of GMP from XMP
CIW72_10445	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CIW72_10450	COG0582	viral genome integration into host DNA
CIW72_10490	COG0667	Aldo Keto reductase
CIW72_10560	COG3002	Belongs to the UPF0753 family
CIW72_10565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CIW72_10570	COG0583	DNA-binding transcription factor activity
CIW72_10590	COG2197	response regulator
CIW72_10605	COG1335	isochorismatase
CIW72_10620	COG2814	Major facilitator Superfamily
CIW72_10630	COG1914	H( )-stimulated, divalent metal cation uptake system
CIW72_10635	COG1321	iron dependent repressor
CIW72_10640	COG0590	tRNA wobble adenosine to inosine editing
CIW72_10645	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CIW72_10650	COG0668	transmembrane transport
CIW72_10660	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CIW72_10675	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_10680	COG1183	phosphatidylcholine synthase activity
CIW72_10690	COG3243	poly(R)-hydroxyalkanoic acid synthase
CIW72_10705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CIW72_10705	COG0723	plastoquinol--plastocyanin reductase activity
CIW72_10715	COG2183	response to ionizing radiation
CIW72_10725	COG0784	Response regulator, receiver
CIW72_10725	COG2205	protein histidine kinase activity
CIW72_10820	COG0800	Aldolase
CIW72_10825	COG0129	dihydroxy-acid dehydratase activity
CIW72_10830	COG0363	glucosamine-6-phosphate deaminase activity
CIW72_10835	COG0837	glucose binding
CIW72_10840	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CIW72_10865	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CIW72_10880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CIW72_10885	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CIW72_10895	COG4591	ABC-type transport system involved in lipoprotein release permease component
CIW72_10900	COG1136	(ABC) transporter
CIW72_10915	COG0811	peptide transport
CIW72_10925	COG1132	(ABC) transporter
CIW72_10930	COG1663	tetraacyldisaccharide 4'-kinase activity
CIW72_10935	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CIW72_10940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CIW72_10950	COG0322	excinuclease ABC activity
CIW72_10955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CIW72_10990	COG0643	Histidine kinase
CIW72_10990	COG2198	Histidine kinase
CIW72_11010	COG0455	bacterial-type flagellum organization
CIW72_11020	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CIW72_11035	COG5001	Diguanylate cyclase
CIW72_11035	COG3300	MHYT domain
CIW72_11050	COG3318	Belongs to the UPF0149 family
CIW72_11050	COG3012	SEC-C Motif Domain Protein
CIW72_11070	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CIW72_11080	COG1684	flagellar biosynthetic protein fliR
CIW72_11085	COG1987	bacterial-type flagellum assembly
CIW72_11095	COG3190	flagellar
CIW72_11145	COG1677	Flagellar hook-basal body complex protein FliE
CIW72_11185	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_11190	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_11195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CIW72_11210	COG2204	response regulator
CIW72_11215	COG2201	protein-glutamate methylesterase activity
CIW72_11245	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CIW72_11250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CIW72_11255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CIW72_11265	COG1705	Flagellar rod assembly protein muramidase FlgJ
CIW72_11265	COG3951	Flagellar rod assembly protein muramidase FlgJ
CIW72_11270	COG1706	bacterial-type flagellum-dependent cell motility
CIW72_11275	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CIW72_11280	COG4786	Flagellar basal body rod
CIW72_11295	COG4787	bacterial-type flagellum-dependent cell motility
CIW72_11300	COG1749	Flagellar hook protein flgE
CIW72_11305	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CIW72_11310	COG1558	bacterial-type flagellum-dependent cell motility
CIW72_11320	COG0784	Response regulator, receiver
CIW72_11320	COG0835	chemotaxis
CIW72_11340	COG5002	protein histidine kinase activity
CIW72_11370	COG2915	High frequency lysogenization protein hflD homolog
CIW72_11375	COG0482	sulfurtransferase activity
CIW72_11385	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CIW72_11390	COG0542	response to heat
CIW72_11395	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CIW72_11400	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CIW72_11410	COG0492	ferredoxin-NADP+ reductase activity
CIW72_11415	COG1674	ftsk spoiiie
CIW72_11425	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CIW72_11435	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CIW72_11440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CIW72_11450	COG0183	Belongs to the thiolase family
CIW72_11455	COG1024	Enoyl-CoA hydratase
CIW72_11455	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIW72_11465	COG0105	UTP biosynthetic process
CIW72_11470	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CIW72_11480	COG1426	Protein conserved in bacteria
CIW72_11490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CIW72_11495	COG1160	GTP binding
CIW72_11500	COG0303	'Molybdopterin
CIW72_11505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CIW72_11660	COG0708	Exodeoxyribonuclease III
CIW72_11670	COG0303	'Molybdopterin
CIW72_11675	COG0746	molybdenum cofactor guanylyltransferase activity
CIW72_11685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CIW72_11685	COG1648	precorrin-2 dehydrogenase activity
CIW72_11710	COG3685	Protein conserved in bacteria
CIW72_11730	COG5001	Diguanylate cyclase
CIW72_11740	COG4566	intracellular signal transduction
CIW72_11760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIW72_11785	COG3279	Response regulator of the LytR AlgR family
CIW72_11820	COG1238	metal cluster binding
CIW72_12085	COG0316	Belongs to the HesB IscA family
CIW72_12085	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CIW72_12090	COG2154	pterin-4-alpha-carbinolamine dehydratase
CIW72_12100	COG0428	transporter
CIW72_12115	COG1530	ribonuclease E activity
CIW72_12145	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CIW72_12215	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CIW72_12220	COG1360	Flagellar Motor Protein
CIW72_12225	COG1192	Involved in chromosome partitioning
CIW72_12230	COG0835	chemotaxis
CIW72_12240	COG0745	RESPONSE REGULATOR receiver
CIW72_12250	COG0840	transmembrane signaling receptor activity
CIW72_12260	COG0840	transmembrane signaling receptor activity
CIW72_12265	COG0840	transmembrane signaling receptor activity
CIW72_12280	COG0840	transmembrane signaling receptor activity
CIW72_12285	COG0840	transmembrane signaling receptor activity
CIW72_12290	COG0840	transmembrane signaling receptor activity
CIW72_12305	COG0840	transmembrane signaling receptor activity
CIW72_12310	COG0840	transmembrane signaling receptor activity
CIW72_12315	COG0840	transmembrane signaling receptor activity
CIW72_12340	COG0835	chemotaxis
CIW72_12350	COG0840	transmembrane signaling receptor activity
CIW72_12360	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CIW72_12365	COG2201	protein-glutamate methylesterase activity
CIW72_12375	COG2267	carboxylic ester hydrolase activity
CIW72_12405	COG0318	PFAM AMP-dependent synthetase and ligase
CIW72_12410	COG1024	Enoyl-CoA hydratase
CIW72_12415	COG2205	protein histidine kinase activity
CIW72_12415	COG2198	Histidine kinase
CIW72_12415	COG0784	Response regulator, receiver
CIW72_12425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CIW72_12430	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CIW72_12435	COG3279	Response regulator of the LytR AlgR family
CIW72_12495	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CIW72_12505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CIW72_12510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CIW72_12520	COG0505	Belongs to the CarA family
CIW72_12525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CIW72_12530	COG2258	MOSC domain
CIW72_12535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIW72_12580	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CIW72_12600	COG0277	FAD linked oxidase domain protein
CIW72_12605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CIW72_12615	COG0531	amino acid
CIW72_12620	COG0531	amino acid
CIW72_12625	COG0235	Class ii aldolase
CIW72_12630	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CIW72_12635	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CIW72_12650	COG0140	phosphoribosyl-ATP diphosphatase activity
CIW72_12650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CIW72_12655	COG0107	imidazoleglycerol-phosphate synthase activity
CIW72_12660	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CIW72_12665	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CIW72_12670	COG0131	Imidazoleglycerol-phosphate dehydratase
CIW72_12670	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CIW72_12675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CIW72_12680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CIW72_12685	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CIW72_12695	COG0124	histidyl-tRNA synthetase
CIW72_12700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CIW72_12800	COG0726	polysaccharide deacetylase
CIW72_12800	COG1649	PFAM Uncharacterised BCR, COG1649
CIW72_12805	COG1215	transferase activity, transferring glycosyl groups
CIW72_12830	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CIW72_12830	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CIW72_12955	COG1012	belongs to the aldehyde dehydrogenase family
CIW72_12975	COG0167	dihydroorotate dehydrogenase activity
CIW72_12980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CIW72_12985	COG0697	spore germination
CIW72_12995	COG1794	racemase activity, acting on amino acids and derivatives
CIW72_13010	COG0671	phosphoesterase, PA-phosphatase related
CIW72_13015	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CIW72_13030	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CIW72_13035	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CIW72_13045	COG2203	Gaf domain
CIW72_13045	COG3706	GGDEF domain
CIW72_13045	COG4251	negative regulation of phosphorylation
CIW72_13045	COG5001	Diguanylate cyclase
CIW72_13060	COG1472	Belongs to the glycosyl hydrolase 3 family
CIW72_13085	COG0166	Belongs to the GPI family
CIW72_13090	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CIW72_13095	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CIW72_13100	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CIW72_13120	COG1469	GTP cyclohydrolase I activity
CIW72_13125	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIW72_13145	COG0477	Major facilitator Superfamily
CIW72_13150	COG2115	Belongs to the xylose isomerase family
CIW72_13155	COG1070	Carbohydrate kinase
CIW72_13165	COG1501	Belongs to the glycosyl hydrolase 31 family
CIW72_13205	COG0800	Aldolase
CIW72_13210	COG4948	Mandelate Racemase Muconate Lactonizing
CIW72_13220	COG3734	2-keto-3-deoxy-galactonokinase
CIW72_13225	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CIW72_13235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CIW72_13250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CIW72_13255	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CIW72_13270	COG0351	phosphomethylpyrimidine kinase
CIW72_13310	COG0583	DNA-binding transcription factor activity
CIW72_13315	COG1741	Belongs to the pirin family
CIW72_13335	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CIW72_13340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CIW72_13345	COG2137	regulation of response to DNA damage stimulus
CIW72_13355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CIW72_13360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CIW72_13370	COG1546	Belongs to the CinA family
CIW72_13375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CIW72_13380	COG1923	regulation of RNA biosynthetic process
CIW72_13385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CIW72_13390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CIW72_13395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CIW72_13400	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CIW72_13405	COG1534	Rna-binding protein
CIW72_13420	COG1238	metal cluster binding
CIW72_13425	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CIW72_13430	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CIW72_13435	COG2840	Smr protein MutS2
CIW72_13440	COG0585	pseudouridine synthase activity
CIW72_13445	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CIW72_13450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CIW72_13455	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CIW72_13460	COG0148	phosphopyruvate hydratase activity
CIW72_13470	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CIW72_13475	COG0504	CTP synthase activity
CIW72_13500	COG0306	phosphate transporter
CIW72_13515	COG1253	flavin adenine dinucleotide binding
CIW72_13530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIW72_13535	COG0477	Major facilitator Superfamily
CIW72_13540	COG1132	(ABC) transporter
CIW72_13545	COG1136	(ABC) transporter
CIW72_13570	COG2264	protein methyltransferase activity
CIW72_13605	COG2244	polysaccharide biosynthetic process
CIW72_13705	COG1595	DNA-templated transcription, initiation
CIW72_13720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CIW72_13730	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CIW72_13740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIW72_13755	COG0784	Response regulator, receiver
CIW72_13755	COG4191	Histidine kinase
CIW72_13765	COG2205	protein histidine kinase activity
CIW72_13765	COG0784	Response regulator, receiver
CIW72_13765	COG5002	protein histidine kinase activity
CIW72_13790	COG0840	transmembrane signaling receptor activity
CIW72_13805	COG0583	DNA-binding transcription factor activity
CIW72_13810	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CIW72_13815	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CIW72_13830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CIW72_13835	COG1605	Chorismate mutase
CIW72_13835	COG0077	Prephenate dehydratase
CIW72_13840	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CIW72_13845	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CIW72_13850	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CIW72_13890	COG1228	amidohydrolase
CIW72_13895	COG2986	histidine ammonia-lyase
CIW72_13905	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CIW72_13915	COG4993	Dehydrogenase
CIW72_13925	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CIW72_13940	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CIW72_13945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CIW72_13950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CIW72_13960	COG3115	cell septum assembly
CIW72_13970	COG0359	binds to the 23S rRNA
CIW72_13975	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CIW72_13980	COG0360	Binds together with S18 to 16S ribosomal RNA
CIW72_13985	COG0316	Belongs to the HesB IscA family
CIW72_13995	COG0017	Asparaginyl-tRNA synthetase
CIW72_14015	COG2808	Putative FMN-binding domain
CIW72_14090	COG0288	reversible hydration of carbon dioxide
CIW72_14095	COG0662	Cupin 2, conserved barrel domain protein
CIW72_14105	COG3844	kynureninase activity
CIW72_14110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CIW72_14115	COG2925	Exonuclease
CIW72_14140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CIW72_14145	COG0116	Belongs to the methyltransferase superfamily
CIW72_14145	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CIW72_14190	COG0494	nUDIX hydrolase
CIW72_14200	COG1024	Enoyl-CoA hydratase
CIW72_14210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CIW72_14215	COG0659	secondary active sulfate transmembrane transporter activity
CIW72_14240	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CIW72_14245	COG0573	inorganic phosphate transmembrane transporter activity
CIW72_14250	COG0581	inorganic phosphate transmembrane transporter activity
CIW72_14255	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CIW72_14260	COG0704	Plays a role in the regulation of phosphate uptake
CIW72_14270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CIW72_14275	COG3706	GGDEF domain
CIW72_14280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CIW72_14290	COG0557	exoribonuclease II activity
CIW72_14310	COG1960	acyl-CoA dehydrogenase activity
CIW72_14315	COG1960	acyl-CoA dehydrogenase activity
CIW72_14330	COG1960	acyl-CoA dehydrogenase activity
CIW72_14340	COG0646	methionine synthase
CIW72_14340	COG1410	methionine synthase
CIW72_14355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIW72_14380	COG2900	Belongs to the SlyX family
CIW72_14395	COG0386	Belongs to the glutathione peroxidase family
CIW72_14405	COG1725	Transcriptional regulator
CIW72_14410	COG1131	(ABC) transporter
CIW72_14440	COG1253	flavin adenine dinucleotide binding
CIW72_14460	COG2850	peptidyl-arginine hydroxylation
CIW72_14495	COG1132	(ABC) transporter
CIW72_14500	COG0583	DNA-binding transcription factor activity
CIW72_14530	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CIW72_14540	COG0484	heat shock protein binding
CIW72_14545	COG0443	Heat shock 70 kDa protein
CIW72_14550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CIW72_14555	COG1420	regulation of RNA biosynthetic process
CIW72_14560	COG0497	DNA recombination
CIW72_14570	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CIW72_14585	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CIW72_14640	COG3706	GGDEF domain
CIW72_14650	COG3706	GGDEF domain
CIW72_14685	COG0583	DNA-binding transcription factor activity
CIW72_14700	COG0415	Belongs to the DNA photolyase family
CIW72_14705	COG0305	Participates in initiation and elongation during chromosome replication
CIW72_14715	COG0367	asparagine synthase
CIW72_14735	COG1960	acyl-CoA dehydrogenase activity
CIW72_14750	COG0084	hydrolase, TatD family'
CIW72_14755	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CIW72_14810	COG0386	Belongs to the glutathione peroxidase family
CIW72_14820	COG0339	signal peptide processing
CIW72_14850	COG3104	oligopeptide transport
CIW72_14870	COG2814	Major facilitator Superfamily
CIW72_14875	COG1566	PFAM secretion protein HlyD family protein
CIW72_14900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CIW72_14920	COG4774	siderophore transport
CIW72_14930	COG0367	asparagine synthase
CIW72_14935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CIW72_14940	COG1393	Belongs to the ArsC family
CIW72_14950	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CIW72_14955	COG0024	Methionine aminopeptidase
CIW72_14990	COG0052	Belongs to the universal ribosomal protein uS2 family
CIW72_14995	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CIW72_15000	COG0745	RESPONSE REGULATOR receiver
CIW72_15000	COG3706	GGDEF domain
CIW72_15005	COG0528	UMP kinase activity
CIW72_15010	COG0233	cytoplasmic translational termination
CIW72_15015	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CIW72_15020	COG0575	Belongs to the CDS family
CIW72_15025	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CIW72_15030	COG0750	zinc metalloprotease
CIW72_15045	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CIW72_15050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CIW72_15055	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CIW72_15060	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CIW72_15065	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CIW72_15075	COG0825	malonyl-CoA metabolic process
CIW72_15110	COG1695	Transcriptional regulator
CIW72_15130	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CIW72_15140	COG2040	homocysteine
CIW72_15145	COG0833	amino acid
CIW72_15150	COG0346	lactoylglutathione lyase activity
CIW72_15155	COG1131	(ABC) transporter
CIW72_15170	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CIW72_15170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CIW72_15180	COG2878	Part of a membrane complex involved in electron transport
CIW72_15195	COG1595	DNA-templated transcription, initiation
CIW72_15220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CIW72_15235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CIW72_15240	COG0251	oxidation-reduction process
CIW72_15250	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CIW72_15250	COG0392	lysyltransferase activity
CIW72_15285	COG2814	Major facilitator Superfamily
CIW72_15295	COG2824	Alkylphosphonate utilization operon protein PhnA
CIW72_15305	COG1047	Peptidyl-prolyl cis-trans
CIW72_15310	COG1077	Cell shape determining protein MreB Mrl
CIW72_15325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CIW72_15335	COG5487	UPF0391 membrane protein
CIW72_15340	COG1451	nucleotide metabolic process
CIW72_15365	COG0183	Belongs to the thiolase family
CIW72_15385	COG0745	RESPONSE REGULATOR receiver
CIW72_15385	COG3706	GGDEF domain
CIW72_15400	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CIW72_15400	COG1793	dna ligase
CIW72_15410	COG1793	dna ligase
CIW72_15415	COG1201	RNA secondary structure unwinding
CIW72_15425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CIW72_15430	COG1278	Cold shock
CIW72_15435	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CIW72_15445	COG1472	Belongs to the glycosyl hydrolase 3 family
CIW72_15450	COG3046	protein related to deoxyribodipyrimidine photolyase
CIW72_15460	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CIW72_15470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CIW72_15480	COG1381	Involved in DNA repair and RecF pathway recombination
CIW72_15485	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CIW72_15490	COG0571	ribonuclease III activity
CIW72_15505	COG0481	GTPase activity
CIW72_15510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CIW72_15525	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIW72_15525	COG1024	Enoyl-CoA hydratase
CIW72_15550	COG1960	acyl-CoA dehydrogenase activity
CIW72_15570	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CIW72_15635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CIW72_15645	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CIW72_15665	COG0534	Mate efflux family protein
CIW72_15670	COG0335	large ribosomal subunit rRNA binding
CIW72_15675	COG0336	Belongs to the RNA methyltransferase TrmD family
CIW72_15680	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CIW72_15685	COG0228	four-way junction DNA binding
CIW72_15690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CIW72_15700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CIW72_15705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CIW72_15730	COG4191	Histidine kinase
CIW72_15730	COG0784	Response regulator, receiver
CIW72_15735	COG3850	Histidine kinase
CIW72_15735	COG4999	Histidine kinase
CIW72_15735	COG3437	response regulator, receiver
CIW72_15735	COG2205	protein histidine kinase activity
CIW72_15740	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CIW72_15750	COG0745	RESPONSE REGULATOR receiver
CIW72_15750	COG3706	GGDEF domain
CIW72_15755	COG5507	3-demethylubiquinone-9 3-methyltransferase
CIW72_15765	COG4771	TonB-dependent receptor
CIW72_15790	COG2172	sigma factor antagonist activity
CIW72_15795	COG1366	Belongs to the anti-sigma-factor antagonist family
CIW72_15800	COG1366	Belongs to the anti-sigma-factor antagonist family
CIW72_15815	COG0326	Molecular chaperone. Has ATPase activity
CIW72_15820	COG2207	Transcriptional regulator
CIW72_15830	COG3152	Membrane
CIW72_15845	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CIW72_15850	COG1845	cytochrome c oxidase, subunit III
CIW72_15855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CIW72_15895	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CIW72_15895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIW72_15990	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CIW72_15995	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CIW72_16000	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CIW72_16005	COG0196	riboflavin kinase activity
CIW72_16010	COG0728	peptidoglycan biosynthetic process
CIW72_16015	COG0268	Binds directly to 16S ribosomal RNA
CIW72_16020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CIW72_16025	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CIW72_16030	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CIW72_16035	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CIW72_16040	COG0824	Thioesterase
CIW72_16055	COG1946	Acyl-CoA thioesterase
CIW72_16080	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CIW72_16090	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CIW72_16125	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CIW72_16140	COG2197	response regulator
CIW72_16145	COG4585	Histidine kinase
CIW72_16160	COG0850	regulation of cytokinetic process
CIW72_16165	COG2894	cell division
CIW72_16170	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CIW72_16180	COG0642	Histidine kinase
CIW72_16185	COG0745	RESPONSE REGULATOR receiver
CIW72_16200	COG2194	sulfuric ester hydrolase activity
CIW72_16215	COG2814	Major facilitator Superfamily
CIW72_16220	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CIW72_16220	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CIW72_16230	COG0656	L-ascorbic acid biosynthetic process
CIW72_16235	COG0753	catalase activity
CIW72_16270	COG2207	Transcriptional regulator
CIW72_16270	COG1917	Cupin 2, conserved barrel domain protein
CIW72_16310	COG1297	OPT oligopeptide transporter protein
CIW72_16330	COG0587	DNA-directed DNA polymerase activity
CIW72_16345	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CIW72_16380	COG2080	2 iron, 2 sulfur cluster binding
CIW72_16385	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CIW72_16415	COG0492	ferredoxin-NADP+ reductase activity
CIW72_16425	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_16430	COG3537	Alpha-1,2-mannosidase
CIW72_16440	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_16470	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CIW72_16480	COG1196	nuclear chromosome segregation
CIW72_16485	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CIW72_16510	COG1309	transcriptional regulator
CIW72_16515	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_16525	COG0308	aminopeptidase N
CIW72_16530	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CIW72_16540	COG0330	HflC and HflK could
CIW72_16545	COG0330	HflC and HflK could
CIW72_16565	COG0678	peroxiredoxin activity
CIW72_16575	COG4953	penicillin-binding protein 1C
CIW72_16640	COG3829	transcription factor binding
CIW72_16665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CIW72_16670	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CIW72_16680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CIW72_16685	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_16700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CIW72_16705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CIW72_16710	COG1399	metal-binding, possibly nucleic acid-binding protein
CIW72_16715	COG0424	maF-like protein
CIW72_16735	COG0714	Associated with various cellular activities
CIW72_16755	COG0537	adenosine 5'-monophosphoramidase activity
CIW72_16760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CIW72_16765	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CIW72_16770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CIW72_16785	COG0314	molybdopterin synthase activity
CIW72_16790	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CIW72_16795	COG0315	cyclic pyranopterin monophosphate synthase activity
CIW72_16800	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CIW72_16805	COG1234	tRNA 3'-trailer cleavage
CIW72_16810	COG3642	lipopolysaccharide core region biosynthetic process
CIW72_16815	COG0859	PFAM glycosyl transferase family 9
CIW72_16830	COG0631	protein serine/threonine phosphatase activity
CIW72_16835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CIW72_16840	COG0328	RNA-DNA hybrid ribonuclease activity
CIW72_16850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIW72_16860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CIW72_16890	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CIW72_16895	COG0740	serine-type endopeptidase activity
CIW72_16900	COG0544	peptidyl-prolyl cis-trans isomerase activity
CIW72_16910	COG3852	Histidine kinase
CIW72_16915	COG2201	protein-glutamate methylesterase activity
CIW72_17030	COG2944	sequence-specific DNA binding
CIW72_17105	COG2022	thiamine diphosphate biosynthetic process
CIW72_17115	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CIW72_17120	COG0471	metal ion transport
CIW72_17120	COG3273	potassium ion transport
CIW72_17145	COG1970	mechanosensitive ion channel activity
CIW72_17155	COG1609	Transcriptional regulator
CIW72_17165	COG3250	beta-galactosidase activity
CIW72_17170	COG4948	Mandelate Racemase Muconate Lactonizing
CIW72_17185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CIW72_17195	COG0308	aminopeptidase N
CIW72_17215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIW72_17225	COG2895	sulfate adenylyltransferase (ATP) activity
CIW72_17225	COG0529	Catalyzes the synthesis of activated sulfate
CIW72_17230	COG0175	sulfate reduction
CIW72_17235	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CIW72_17240	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CIW72_17245	COG0175	sulfate reduction
CIW72_17285	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CIW72_17285	COG1648	precorrin-2 dehydrogenase activity
CIW72_17300	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CIW72_17305	COG3588	fructose-bisphosphate aldolase
CIW72_17315	COG0469	pyruvate kinase activity
CIW72_17325	COG0126	phosphoglycerate kinase activity
CIW72_17350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CIW72_17360	COG3047	cAMP biosynthetic process
CIW72_17365	COG3047	cAMP biosynthetic process
CIW72_17375	COG3453	Protein conserved in bacteria
CIW72_17375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIW72_17380	COG0725	ABC transporter, periplasmic molybdate-binding protein
CIW72_17385	COG4149	molybdate abc transporter
CIW72_17390	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CIW72_17425	COG1376	ErfK ybiS ycfS ynhG family protein
CIW72_17430	COG0739	heme binding
CIW72_17445	COG4773	Receptor
CIW72_17455	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CIW72_17460	COG1301	dicarboxylic acid transport
CIW72_17475	COG2304	oxidoreductase activity
CIW72_17495	COG0714	Associated with various cellular activities
CIW72_17530	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CIW72_17545	COG0254	rRNA binding
CIW72_17555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CIW72_17565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CIW72_17570	COG1758	RNA polymerase activity
CIW72_17575	COG0194	GDP metabolic process
CIW72_17580	COG1561	YicC-like family, N-terminal region
CIW72_17585	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CIW72_17595	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CIW72_17600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CIW72_17615	COG0006	proline dipeptidase activity
CIW72_17625	COG0006	proline dipeptidase activity
CIW72_17630	COG3079	Belongs to the UPF0149 family
CIW72_17650	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CIW72_17660	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CIW72_17670	COG2912	Transglutaminase-like superfamily
CIW72_17675	COG1773	rubredoxin
CIW72_17680	COG0352	thiamine-phosphate diphosphorylase activity
CIW72_17695	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CIW72_17705	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
CIW72_17710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CIW72_17740	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CIW72_17745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CIW72_17750	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_17760	COG0671	phosphoesterase, PA-phosphatase related
CIW72_17765	COG3781	membrane
CIW72_17775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CIW72_17780	COG0563	adenylate kinase activity
CIW72_17795	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CIW72_17805	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CIW72_17825	COG3710	Transcriptional regulator
CIW72_17830	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CIW72_17845	COG0840	transmembrane signaling receptor activity
CIW72_17850	COG0405	Gamma-glutamyltransferase
CIW72_17855	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CIW72_17875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CIW72_17880	COG0473	3-isopropylmalate dehydrogenase activity
CIW72_17885	COG0066	3-isopropylmalate dehydratase activity
CIW72_17890	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CIW72_17910	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CIW72_17915	COG1538	Outer membrane efflux protein
CIW72_17920	COG1519	Transferase
CIW72_17930	COG1560	Kdo2-lipid A biosynthetic process
CIW72_17955	COG0281	malic enzyme
CIW72_17955	COG0280	phosphate acetyltransferase
CIW72_17960	COG1301	dicarboxylic acid transport
CIW72_17990	COG0583	DNA-binding transcription factor activity
CIW72_17995	COG0667	Aldo Keto reductase
CIW72_18010	COG2197	response regulator
CIW72_18015	COG1840	ABC-type Fe3 transport system, periplasmic component
CIW72_18020	COG0642	Histidine kinase
CIW72_18040	COG2851	Citrate transporter
CIW72_18045	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_18050	COG1609	Transcriptional regulator
CIW72_18055	COG2211	Major facilitator Superfamily
CIW72_18080	COG1162	GTPase activity
CIW72_18150	COG4773	Receptor
CIW72_18155	COG0726	polysaccharide deacetylase
CIW72_18160	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CIW72_18175	COG3964	amidohydrolase
CIW72_18180	COG0402	S-adenosylhomocysteine deaminase activity
CIW72_18205	COG1307	EDD domain protein, DegV family
CIW72_18210	COG0242	peptide deformylase activity
CIW72_18240	COG0457	Tetratricopeptide repeat
CIW72_18245	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CIW72_18250	COG1215	transferase activity, transferring glycosyl groups
CIW72_18255	COG1215	transferase activity, transferring glycosyl groups
CIW72_18270	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CIW72_18325	COG2188	Transcriptional regulator
CIW72_18335	COG1450	Type ii and iii secretion system protein
CIW72_18350	COG3166	PFAM Fimbrial assembly family protein
CIW72_18355	COG3156	type II secretion system protein K
CIW72_18360	COG4795	General secretion pathway protein
CIW72_18365	COG2165	general secretion pathway protein
CIW72_18370	COG4970	Tfp pilus assembly protein FimT
CIW72_18375	COG2165	general secretion pathway protein
CIW72_18380	COG1459	type II secretion system
CIW72_18390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CIW72_18395	COG1404	Belongs to the peptidase S8 family
CIW72_18405	COG1404	Belongs to the peptidase S8 family
CIW72_18415	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CIW72_18415	COG0047	phosphoribosylformylglycinamidine synthase activity
CIW72_18430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CIW72_18445	COG4974	Belongs to the 'phage' integrase family
CIW72_18460	COG0795	lipopolysaccharide-transporting ATPase activity
CIW72_18470	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CIW72_18485	COG0525	valine-tRNA ligase activity
CIW72_18515	COG1183	phosphatidylcholine synthase activity
CIW72_18525	COG0442	prolyl-tRNA aminoacylation
CIW72_18540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CIW72_18545	COG1127	ABC transporter
CIW72_18550	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CIW72_18550	COG3218	ABC-type transport auxiliary lipoprotein component
CIW72_18580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CIW72_18585	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CIW72_18585	COG0662	Cupin 2, conserved barrel domain protein
CIW72_18615	COG2086	electron transfer activity
CIW72_18630	COG0463	Glycosyl transferase, family 2
CIW72_18650	COG2813	Specifically methylates the guanine in position
CIW72_18665	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CIW72_18670	COG0438	transferase activity, transferring glycosyl groups
CIW72_18690	COG0438	transferase activity, transferring glycosyl groups
CIW72_18700	COG0626	cystathionine gamma-synthase activity
CIW72_18730	COG0625	glutathione transferase activity
CIW72_18745	COG0513	Belongs to the DEAD box helicase family
CIW72_18755	COG4206	TonB-dependent receptor
CIW72_18765	COG0720	synthase
CIW72_18775	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CIW72_18780	COG1956	GAF domain-containing protein
CIW72_18790	COG2819	hydrolase of the alpha beta superfamily
CIW72_18805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CIW72_18810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CIW72_18825	COG0339	signal peptide processing
CIW72_18875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CIW72_18880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIW72_18885	COG1136	(ABC) transporter
CIW72_18890	COG0577	efflux transmembrane transporter activity
CIW72_18890	COG1136	(ABC) transporter
CIW72_18895	COG0577	efflux transmembrane transporter activity
CIW72_18910	COG4191	Histidine kinase
CIW72_18915	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CIW72_18930	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CIW72_18935	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CIW72_18940	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CIW72_18945	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CIW72_18950	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CIW72_18955	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CIW72_18965	COG0356	it plays a direct role in the translocation of protons across the membrane
CIW72_18985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CIW72_18995	COG0508	dehydrogenase complex catalyzes the overall conversion of
CIW72_19035	COG2011	ABC-type metal ion transport system permease component
CIW72_19040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CIW72_19045	COG0697	spore germination
CIW72_19050	COG1666	GTP binding
CIW72_19060	COG2198	Histidine kinase
CIW72_19060	COG0784	Response regulator, receiver
CIW72_19060	COG5002	protein histidine kinase activity
CIW72_19080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CIW72_19090	COG2813	Specifically methylates the guanine in position
CIW72_19115	COG2202	Pas domain
CIW72_19115	COG2205	protein histidine kinase activity
CIW72_19135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CIW72_19140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CIW72_19145	COG1522	sequence-specific DNA binding
CIW72_19200	COG0842	Transport permease protein
CIW72_19205	COG1131	(ABC) transporter
CIW72_19210	COG0025	NhaP-type Na H and K H
CIW72_19220	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CIW72_19225	COG1573	uracil-dna glycosylase
CIW72_19235	COG3384	dioxygenase
CIW72_19245	COG0583	DNA-binding transcription factor activity
CIW72_19255	COG0667	Aldo Keto reductase
CIW72_19270	COG3590	peptidase
CIW72_19290	COG0531	amino acid
CIW72_19305	COG2972	Histidine kinase
CIW72_19330	COG3685	Protein conserved in bacteria
CIW72_19335	COG3546	catalase activity
CIW72_19385	COG1271	oxidase subunit
CIW72_19390	COG1294	oxidase, subunit
CIW72_19405	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_19410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CIW72_19430	COG1132	(ABC) transporter
CIW72_19445	COG1063	alcohol dehydrogenase
CIW72_19530	COG0583	DNA-binding transcription factor activity
CIW72_19535	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CIW72_19580	COG0024	Methionine aminopeptidase
CIW72_19605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CIW72_19610	COG1490	D-aminoacyl-tRNA deacylase activity
CIW72_19615	COG1560	Kdo2-lipid A biosynthetic process
CIW72_19670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CIW72_19670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CIW72_19675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CIW72_19680	COG0242	peptide deformylase activity
CIW72_19685	COG1652	LysM domain
CIW72_19690	COG0758	DNA mediated transformation
CIW72_19710	COG1754	DNA topoisomerase type I activity
CIW72_19710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CIW72_19715	COG0009	L-threonylcarbamoyladenylate synthase
CIW72_19730	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_19745	COG0616	signal peptide processing
CIW72_19750	COG0534	Mate efflux family protein
CIW72_19770	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CIW72_19775	COG0625	glutathione transferase activity
CIW72_19790	COG1252	NADH dehydrogenase
CIW72_19795	COG2860	membrane
CIW72_19800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CIW72_19805	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CIW72_19810	COG3437	response regulator, receiver
CIW72_19815	COG2177	Part of the ABC transporter FtsEX involved in
CIW72_19820	COG2884	Cell division ATP-binding protein ftsE
CIW72_19830	COG3118	belongs to the thioredoxin family
CIW72_19835	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CIW72_19845	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CIW72_19850	COG0583	DNA-binding transcription factor activity
CIW72_19870	COG1652	LysM domain
CIW72_19875	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CIW72_19875	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CIW72_19880	COG1473	amidohydrolase
CIW72_19885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIW72_19890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIW72_19900	COG5383	Protein conserved in bacteria
CIW72_19950	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CIW72_19955	COG3023	N-Acetylmuramoyl-L-alanine amidase
CIW72_19965	COG4948	Mandelate Racemase Muconate Lactonizing
CIW72_19975	COG0531	amino acid
CIW72_19990	COG4682	membrane
CIW72_19995	COG2133	pyrroloquinoline quinone binding
CIW72_20005	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CIW72_20010	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CIW72_20015	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CIW72_20020	COG1610	YqeY-like protein
CIW72_20030	COG1295	ribonuclease BN
CIW72_20035	COG0358	DNA primase activity
CIW72_20050	COG0109	protoheme IX farnesyltransferase activity
CIW72_20080	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CIW72_20095	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CIW72_20140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CIW72_20145	COG0739	heme binding
CIW72_20150	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CIW72_20160	COG2211	Major facilitator Superfamily
CIW72_20165	COG0708	Exodeoxyribonuclease III
CIW72_20170	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CIW72_20180	COG1192	Involved in chromosome partitioning
CIW72_20185	COG1475	DNA binding
CIW72_20205	COG0463	Glycosyl transferase, family 2
CIW72_20225	COG0756	dUTP diphosphatase activity
CIW72_20230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CIW72_20235	COG2003	Belongs to the UPF0758 family
CIW72_20240	COG0018	arginyl-trna synthetase
CIW72_20255	COG4221	oxidoreductase activity
CIW72_20260	COG2755	lipolytic protein G-D-S-L family
CIW72_20260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CIW72_20275	COG1166	arginine decarboxylase activity
CIW72_20280	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CIW72_20320	COG0606	chelatase, subunit chli
CIW72_20335	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CIW72_20375	COG1690	Belongs to the RtcB family
CIW72_20410	COG1090	epimerase
CIW72_20415	COG0745	RESPONSE REGULATOR receiver
CIW72_20420	COG0642	Histidine kinase
CIW72_20450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CIW72_20475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CIW72_20480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CIW72_20495	COG0753	catalase activity
CIW72_20510	COG2197	response regulator
CIW72_20515	COG4585	Histidine kinase
CIW72_20520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIW72_20525	COG1136	(ABC) transporter
CIW72_20570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIW72_20575	COG0180	Tryptophanyl-tRNA synthetase
CIW72_20580	COG3237	CsbD-like
CIW72_20625	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CIW72_20675	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CIW72_20680	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CIW72_20680	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CIW72_20720	COG2205	protein histidine kinase activity
CIW72_20725	COG0745	RESPONSE REGULATOR receiver
CIW72_20735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CIW72_20765	COG1199	ATP-dependent helicase activity
CIW72_20780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CIW72_20845	COG0625	glutathione transferase activity
CIW72_20885	COG4555	ABC transporter
CIW72_20895	COG1476	TRANSCRIPTIONal
CIW72_20940	COG0633	Ferredoxin
CIW72_20940	COG0543	2 iron, 2 sulfur cluster binding
CIW72_20945	COG1131	(ABC) transporter
CIW72_20950	COG0842	Transport permease protein
CIW72_20960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CIW72_20990	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CIW72_21000	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CIW72_21025	COG2239	Acts as a magnesium transporter
CIW72_21045	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CIW72_21050	COG3387	PFAM Glycoside hydrolase 15-related
CIW72_21065	COG3100	YcgL domain-containing protein
CIW72_21070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CIW72_21080	COG0463	Glycosyl transferase, family 2
CIW72_21095	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_21140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CIW72_21155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CIW72_21185	COG1506	peptidase
CIW72_21185	COG0823	Involved in the tonB-independent uptake of proteins
CIW72_21185	COG4946	Tricorn protease homolog
CIW72_21205	COG0408	coproporphyrinogen oxidase activity
CIW72_21250	COG0631	protein serine/threonine phosphatase activity
CIW72_21285	COG3501	Rhs element vgr protein
CIW72_21420	COG0210	DNA helicase
CIW72_21435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIW72_21445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CIW72_21460	COG2159	amidohydrolase
CIW72_21465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CIW72_21470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CIW72_21485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIW72_21505	COG0357	Ribosomal RNA small subunit methyltransferase G
CIW72_21510	COG3540	Alkaline phosphatase
CIW72_21520	COG2091	lysine biosynthetic process via aminoadipic acid
CIW72_21535	COG0708	Exodeoxyribonuclease III
CIW72_21540	COG1940	carbohydrate kinase activity
CIW72_21540	COG1846	Transcriptional regulator
CIW72_21550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CIW72_21560	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CIW72_21565	COG3162	membrane
CIW72_21575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CIW72_21605	COG3507	Belongs to the glycosyl hydrolase 43 family
CIW72_21625	COG1028	Short-chain dehydrogenase reductase Sdr
CIW72_21630	COG0179	Fumarylacetoacetate (FAA) hydrolase
CIW72_21640	COG4948	Mandelate Racemase Muconate Lactonizing
CIW72_21645	COG3254	rhamnose metabolic process
CIW72_21650	COG0738	Major facilitator superfamily
CIW72_21655	COG1414	Transcriptional regulator
CIW72_21665	COG1971	Probably functions as a manganese efflux pump
CIW72_21670	COG2205	protein histidine kinase activity
CIW72_21685	COG3459	Glycosyltransferase 36 associated
CIW72_21690	COG2211	Major facilitator Superfamily
CIW72_21695	COG3265	gluconokinase activity
CIW72_21705	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CIW72_21735	COG2911	Protein conserved in bacteria
CIW72_21740	COG0729	surface antigen
CIW72_21745	COG4771	TonB-dependent receptor
CIW72_21750	COG0457	Tetratricopeptide repeat
CIW72_21760	COG0752	glycyl-tRNA synthetase alpha subunit
CIW72_21765	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CIW72_21780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CIW72_21780	COG0519	Catalyzes the synthesis of GMP from XMP
CIW72_21790	COG0805	protein transport
CIW72_21795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CIW72_21800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CIW72_21810	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CIW72_21835	COG2974	May be involved in recombination
CIW72_21840	COG0037	tRNA processing
CIW72_21850	COG2115	Belongs to the xylose isomerase family
CIW72_21860	COG3661	Belongs to the glycosyl hydrolase 67 family
CIW72_21870	COG4948	Mandelate Racemase Muconate Lactonizing
CIW72_21880	COG1472	Belongs to the glycosyl hydrolase 3 family
CIW72_21885	COG0246	Mannitol dehydrogenase
CIW72_21935	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CIW72_21965	COG3386	PFAM SMP-30 Gluconolaconase
CIW72_21975	COG3250	beta-galactosidase activity
CIW72_21980	COG1904	glucuronate isomerase
CIW72_21995	COG3693	PFAM glycoside hydrolase, family 10
CIW72_22010	COG2211	Major facilitator Superfamily
CIW72_22040	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CIW72_22050	COG1435	thymidine kinase activity
CIW72_22055	COG0210	DNA helicase
CIW72_22070	COG3132	Protein of unknown function, DUF480
CIW72_22080	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CIW72_22085	COG0284	orotidine-5'-phosphate decarboxylase activity
CIW72_22120	COG2937	Belongs to the GPAT DAPAT family
CIW72_22135	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CIW72_22165	COG3135	benzoate transporter
CIW72_22185	COG0676	glucose-6-phosphate 1-epimerase activity
CIW72_22195	COG3012	SEC-C Motif Domain Protein
CIW72_22200	COG0730	response to heat
CIW72_22220	COG0302	gtp cyclohydrolase
CIW72_22235	COG1566	PFAM secretion protein HlyD family protein
CIW72_22245	COG1289	transmembrane transporter activity
CIW72_22250	COG0477	Major facilitator Superfamily
CIW72_22260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIW72_22280	COG4691	Plasmid stability protein
CIW72_22285	COG1487	ribonuclease activity
CIW72_22325	COG1074	ATP-dependent DNA helicase activity
CIW72_22330	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CIW72_22345	COG1127	ABC transporter
CIW72_22350	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CIW72_22355	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CIW72_22370	COG2853	Lipoprotein
CIW72_22380	COG0386	Belongs to the glutathione peroxidase family
CIW72_22390	COG1322	Protein conserved in bacteria
CIW72_22395	COG0604	alcohol dehydrogenase
CIW72_22400	COG0583	DNA-binding transcription factor activity
CIW72_22415	COG0625	glutathione transferase activity
CIW72_22425	COG0531	amino acid
CIW72_22445	COG3706	GGDEF domain
CIW72_22465	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CIW72_22475	COG0861	Integral membrane protein TerC family
CIW72_22490	COG0584	glycerophosphoryl diester phosphodiesterase
CIW72_22505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CIW72_22510	COG0726	polysaccharide deacetylase
CIW72_22515	COG0706	membrane insertase activity
CIW72_22520	COG0594	ribonuclease P activity
CIW72_22525	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CIW72_22530	COG2963	transposase activity
CIW72_22650	COG1192	Involved in chromosome partitioning
CIW72_22705	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CIW72_22755	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CIW72_22775	COG3012	SEC-C Motif Domain Protein
CIW72_22775	COG3318	Belongs to the UPF0149 family
CIW72_22875	COG4456	Virulence-associated protein
CIW72_22935	COG2951	lytic endotransglycosylase activity
CIW72_22975	COG3318	Belongs to the UPF0149 family
CIW72_22975	COG3012	SEC-C Motif Domain Protein
CIW72_22995	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CIW72_23030	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CIW72_23050	COG3012	SEC-C Motif Domain Protein
CIW72_23050	COG3318	Belongs to the UPF0149 family