locus-tag	class	description
APY30_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APY30_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APY30_00020	COG0187	DNA topoisomerase II activity
APY30_00030	COG0501	Belongs to the peptidase M48B family
APY30_00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APY30_00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APY30_00110	COG2003	Belongs to the UPF0758 family
APY30_00120	COG2963	transposase activity
APY30_00135	COG2801	Transposase and inactivated derivatives
APY30_00195	COG0793	Belongs to the peptidase S41A family
APY30_00200	COG4942	peptidase
APY30_00210	COG2234	aminopeptidase activity
APY30_00220	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
APY30_00225	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
APY30_00235	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
APY30_00240	COG1064	alcohol dehydrogenase
APY30_00245	COG0493	'glutamate synthase
APY30_00250	COG0067	glutamate synthase
APY30_00250	COG0069	glutamate synthase activity
APY30_00250	COG0070	glutamate synthase
APY30_00295	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APY30_00310	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
APY30_00315	COG0297	glycogen (starch) synthase activity
APY30_00315	COG0438	transferase activity, transferring glycosyl groups
APY30_00335	COG0367	asparagine synthase
APY30_00365	COG1132	(ABC) transporter
APY30_00395	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
APY30_00475	COG1111	helicase
APY30_00475	COG1205	dead DEAH box helicase
APY30_00480	COG1272	protein, Hemolysin III
APY30_00495	COG0300	oxidoreductase activity
APY30_00500	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_00545	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APY30_00550	COG3710	Transcriptional regulator
APY30_00570	COG2197	response regulator
APY30_00575	COG4585	Histidine kinase
APY30_00585	COG1304	FMN binding
APY30_00640	COG0662	Cupin 2, conserved barrel domain protein
APY30_00650	COG4772	TonB-dependent receptor
APY30_00660	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
APY30_00690	COG0714	Associated with various cellular activities
APY30_00740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APY30_00790	COG0366	Alpha amylase catalytic
APY30_00795	COG0366	Alpha amylase catalytic
APY30_00800	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APY30_00835	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APY30_00840	COG3265	gluconokinase activity
APY30_00845	COG2211	Major facilitator Superfamily
APY30_00850	COG3459	Glycosyltransferase 36 associated
APY30_00865	COG2205	protein histidine kinase activity
APY30_00870	COG1971	Probably functions as a manganese efflux pump
APY30_00880	COG1414	Transcriptional regulator
APY30_00885	COG0738	Major facilitator superfamily
APY30_00890	COG3254	rhamnose metabolic process
APY30_00895	COG4948	Mandelate Racemase Muconate Lactonizing
APY30_00900	COG0179	Fumarylacetoacetate (FAA) hydrolase
APY30_00905	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_00955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APY30_00965	COG3162	membrane
APY30_00970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APY30_00980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APY30_00990	COG1846	Transcriptional regulator
APY30_00990	COG1940	carbohydrate kinase activity
APY30_00995	COG0708	Exodeoxyribonuclease III
APY30_01015	COG2091	lysine biosynthetic process via aminoadipic acid
APY30_01025	COG3540	Alkaline phosphatase
APY30_01030	COG0357	Ribosomal RNA small subunit methyltransferase G
APY30_01050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APY30_01065	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APY30_01070	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APY30_01075	COG2159	amidohydrolase
APY30_01085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APY30_01090	COG0583	DNA-binding transcription factor activity
APY30_01095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APY30_01110	COG0210	DNA helicase
APY30_01235	COG3501	Rhs element vgr protein
APY30_01270	COG0631	protein serine/threonine phosphatase activity
APY30_01275	COG0515	serine threonine protein kinase
APY30_01315	COG0408	coproporphyrinogen oxidase activity
APY30_01330	COG4946	Tricorn protease homolog
APY30_01330	COG1506	peptidase
APY30_01330	COG0823	Involved in the tonB-independent uptake of proteins
APY30_01355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APY30_01370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APY30_01410	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_01425	COG0463	Glycosyl transferase, family 2
APY30_01435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APY30_01440	COG3100	YcgL domain-containing protein
APY30_01455	COG3387	PFAM Glycoside hydrolase 15-related
APY30_01460	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APY30_01475	COG2239	Acts as a magnesium transporter
APY30_01480	COG1042	CoA-binding domain protein
APY30_01480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APY30_01480	COG0045	succinate-CoA ligase (ADP-forming) activity
APY30_01490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APY30_01495	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APY30_01525	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
APY30_01535	COG0842	Transport permease protein
APY30_01540	COG1131	(ABC) transporter
APY30_01545	COG0543	2 iron, 2 sulfur cluster binding
APY30_01545	COG0633	Ferredoxin
APY30_01590	COG1476	TRANSCRIPTIONal
APY30_01600	COG4555	ABC transporter
APY30_01640	COG0625	glutathione transferase activity
APY30_01715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APY30_01730	COG1199	ATP-dependent helicase activity
APY30_01750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APY30_01760	COG0745	RESPONSE REGULATOR receiver
APY30_01765	COG2205	protein histidine kinase activity
APY30_01790	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
APY30_01790	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
APY30_01795	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
APY30_01830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APY30_01870	COG3237	CsbD-like
APY30_01875	COG0180	Tryptophanyl-tRNA synthetase
APY30_01880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APY30_01895	COG0697	spore germination
APY30_01920	COG1136	(ABC) transporter
APY30_01925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APY30_01930	COG4585	Histidine kinase
APY30_01935	COG2197	response regulator
APY30_01950	COG0753	catalase activity
APY30_01965	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APY30_01970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APY30_01995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APY30_02015	COG0642	Histidine kinase
APY30_02020	COG0745	RESPONSE REGULATOR receiver
APY30_02025	COG1090	epimerase
APY30_02065	COG1690	Belongs to the RtcB family
APY30_02100	COG4943	cyclic-guanylate-specific phosphodiesterase activity
APY30_02115	COG0606	chelatase, subunit chli
APY30_02155	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
APY30_02160	COG1166	arginine decarboxylase activity
APY30_02165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APY30_02180	COG4221	oxidoreductase activity
APY30_02195	COG0018	arginyl-trna synthetase
APY30_02200	COG2003	Belongs to the UPF0758 family
APY30_02205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APY30_02210	COG0756	dUTP diphosphatase activity
APY30_02230	COG0463	Glycosyl transferase, family 2
APY30_02245	COG1475	DNA binding
APY30_02250	COG1192	Involved in chromosome partitioning
APY30_02260	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APY30_02265	COG0708	Exodeoxyribonuclease III
APY30_02270	COG2211	Major facilitator Superfamily
APY30_02280	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
APY30_02285	COG0739	heme binding
APY30_02290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APY30_02335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APY30_02345	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
APY30_02375	COG0109	protoheme IX farnesyltransferase activity
APY30_02390	COG0358	DNA primase activity
APY30_02395	COG1295	ribonuclease BN
APY30_02400	COG1610	YqeY-like protein
APY30_02405	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APY30_02410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APY30_02415	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APY30_02425	COG2133	pyrroloquinoline quinone binding
APY30_02430	COG4682	membrane
APY30_02445	COG0531	amino acid
APY30_02455	COG4948	Mandelate Racemase Muconate Lactonizing
APY30_02465	COG3023	N-Acetylmuramoyl-L-alanine amidase
APY30_02470	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
APY30_02510	COG5383	Protein conserved in bacteria
APY30_02520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APY30_02525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APY30_02530	COG1473	amidohydrolase
APY30_02535	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APY30_02535	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APY30_02560	COG0583	DNA-binding transcription factor activity
APY30_02565	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
APY30_02575	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APY30_02580	COG3118	belongs to the thioredoxin family
APY30_02590	COG2884	Cell division ATP-binding protein ftsE
APY30_02595	COG2177	Part of the ABC transporter FtsEX involved in
APY30_02600	COG2201	protein-glutamate methylesterase activity
APY30_02605	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APY30_02610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APY30_02615	COG2860	membrane
APY30_02620	COG1252	NADH dehydrogenase
APY30_02635	COG0625	glutathione transferase activity
APY30_02640	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APY30_02660	COG0534	Mate efflux family protein
APY30_02665	COG0616	signal peptide processing
APY30_02675	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_02690	COG0009	L-threonylcarbamoyladenylate synthase
APY30_02695	COG1754	DNA topoisomerase type I activity
APY30_02695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APY30_02715	COG0758	DNA mediated transformation
APY30_02720	COG1652	LysM domain
APY30_02725	COG0242	peptide deformylase activity
APY30_02730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APY30_02735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APY30_02735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APY30_02785	COG1560	Kdo2-lipid A biosynthetic process
APY30_02790	COG1490	D-aminoacyl-tRNA deacylase activity
APY30_02795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APY30_02810	COG0582	viral genome integration into host DNA
APY30_02845	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APY30_02875	COG0024	Methionine aminopeptidase
APY30_02920	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
APY30_02925	COG0583	DNA-binding transcription factor activity
APY30_03005	COG1063	alcohol dehydrogenase
APY30_03020	COG1132	(ABC) transporter
APY30_03040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APY30_03045	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_03060	COG1294	oxidase, subunit
APY30_03065	COG1271	oxidase subunit
APY30_03110	COG3546	catalase activity
APY30_03115	COG3685	Protein conserved in bacteria
APY30_03140	COG2972	Histidine kinase
APY30_03155	COG0531	amino acid
APY30_03175	COG3590	peptidase
APY30_03185	COG0667	Aldo Keto reductase
APY30_03195	COG0583	DNA-binding transcription factor activity
APY30_03205	COG3384	dioxygenase
APY30_03215	COG1573	uracil-dna glycosylase
APY30_03220	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APY30_03225	COG0025	NhaP-type Na H and K H
APY30_03230	COG1131	(ABC) transporter
APY30_03235	COG0842	Transport permease protein
APY30_03285	COG1522	sequence-specific DNA binding
APY30_03290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APY30_03295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APY30_03315	COG2205	protein histidine kinase activity
APY30_03315	COG2202	Pas domain
APY30_03340	COG1187	pseudouridine synthase activity
APY30_03345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APY30_03370	COG0784	Response regulator, receiver
APY30_03370	COG5002	protein histidine kinase activity
APY30_03370	COG2198	Histidine kinase
APY30_03380	COG1666	GTP binding
APY30_03385	COG0697	spore germination
APY30_03390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APY30_03395	COG2011	ABC-type metal ion transport system permease component
APY30_03445	COG0508	dehydrogenase complex catalyzes the overall conversion of
APY30_03455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APY30_03475	COG0356	it plays a direct role in the translocation of protons across the membrane
APY30_03485	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APY30_03490	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APY30_03495	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APY30_03500	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APY30_03505	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APY30_03510	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APY30_03525	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APY30_03530	COG4191	Histidine kinase
APY30_03535	COG2204	response regulator
APY30_03545	COG0577	efflux transmembrane transporter activity
APY30_03550	COG0577	efflux transmembrane transporter activity
APY30_03555	COG1136	(ABC) transporter
APY30_03555	COG4591	ABC-type transport system involved in lipoprotein release permease component
APY30_03560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APY30_03565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APY30_03600	COG2132	Multicopper oxidase
APY30_03615	COG0339	signal peptide processing
APY30_03630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APY30_03635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APY30_03650	COG2819	hydrolase of the alpha beta superfamily
APY30_03660	COG1956	GAF domain-containing protein
APY30_03665	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APY30_03675	COG0720	synthase
APY30_03680	COG4206	TonB-dependent receptor
APY30_03690	COG0513	Belongs to the DEAD box helicase family
APY30_03700	COG0625	glutathione transferase activity
APY30_03730	COG0626	cystathionine gamma-synthase activity
APY30_03740	COG0438	transferase activity, transferring glycosyl groups
APY30_03760	COG0438	transferase activity, transferring glycosyl groups
APY30_03765	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
APY30_03810	COG0463	Glycosyl transferase, family 2
APY30_03825	COG2086	electron transfer activity
APY30_03855	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
APY30_03855	COG0662	Cupin 2, conserved barrel domain protein
APY30_03860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APY30_03890	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APY30_03890	COG3218	ABC-type transport auxiliary lipoprotein component
APY30_03895	COG1127	ABC transporter
APY30_03900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APY30_03915	COG0442	prolyl-tRNA aminoacylation
APY30_03925	COG1183	phosphatidylcholine synthase activity
APY30_03955	COG0525	valine-tRNA ligase activity
APY30_03970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APY30_03980	COG0795	lipopolysaccharide-transporting ATPase activity
APY30_03995	COG4974	Belongs to the 'phage' integrase family
APY30_04000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APY30_04005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APY30_04005	COG0047	phosphoribosylformylglycinamidine synthase activity
APY30_04015	COG1404	Belongs to the peptidase S8 family
APY30_04020	COG5295	Hep Hag repeat protein
APY30_04025	COG1404	Belongs to the peptidase S8 family
APY30_04030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APY30_04035	COG1459	type II secretion system
APY30_04040	COG2165	general secretion pathway protein
APY30_04045	COG4970	Tfp pilus assembly protein FimT
APY30_04050	COG2165	general secretion pathway protein
APY30_04055	COG4795	General secretion pathway protein
APY30_04060	COG3156	type II secretion system protein K
APY30_04065	COG3166	PFAM Fimbrial assembly family protein
APY30_04080	COG1450	Type ii and iii secretion system protein
APY30_04085	COG2963	transposase activity
APY30_04090	COG2801	Transposase and inactivated derivatives
APY30_04100	COG2188	Transcriptional regulator
APY30_04150	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APY30_04165	COG1215	transferase activity, transferring glycosyl groups
APY30_04170	COG1215	transferase activity, transferring glycosyl groups
APY30_04175	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
APY30_04180	COG0457	Tetratricopeptide repeat
APY30_04205	COG0242	peptide deformylase activity
APY30_04210	COG1307	EDD domain protein, DegV family
APY30_04230	COG0402	S-adenosylhomocysteine deaminase activity
APY30_04235	COG3964	amidohydrolase
APY30_04250	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APY30_04255	COG0726	polysaccharide deacetylase
APY30_04260	COG4773	Receptor
APY30_04300	COG2801	Transposase and inactivated derivatives
APY30_04305	COG2963	transposase activity
APY30_04325	COG2801	Transposase and inactivated derivatives
APY30_04330	COG2963	transposase activity
APY30_04360	COG3386	PFAM SMP-30 Gluconolaconase
APY30_04395	COG0697	spore germination
APY30_04405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APY30_04420	COG0784	Response regulator, receiver
APY30_04420	COG2205	protein histidine kinase activity
APY30_04420	COG5002	protein histidine kinase activity
APY30_04430	COG2197	response regulator
APY30_04440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APY30_04450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APY30_04455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APY30_04460	COG0583	DNA-binding transcription factor activity
APY30_04465	COG3634	alkyl hydroperoxide reductase activity
APY30_04475	COG2890	protein-(glutamine-N5) methyltransferase activity
APY30_04495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APY30_04495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APY30_04525	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APY30_04545	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APY30_04550	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
APY30_04565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APY30_04580	COG1404	Belongs to the peptidase S8 family
APY30_04585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APY30_04610	COG1295	ribonuclease BN
APY30_04615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APY30_04620	COG1254	Belongs to the acylphosphatase family
APY30_04635	COG0521	Mo-molybdopterin cofactor biosynthetic process
APY30_04645	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APY30_04650	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
APY30_04660	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
APY30_04665	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APY30_04675	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APY30_04680	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
APY30_04685	COG0193	aminoacyl-tRNA hydrolase activity
APY30_04690	COG0012	GTP binding
APY30_04710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APY30_04720	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APY30_04725	COG0250	Participates in transcription elongation, termination and antitermination
APY30_04730	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APY30_04735	COG0081	regulation of translation
APY30_04740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APY30_04745	COG0222	ribosome binding
APY30_04750	COG0085	RNA polymerase activity
APY30_04755	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APY30_04760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APY30_04765	COG0049	tRNA binding
APY30_04770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APY30_04775	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APY30_04780	COG0051	transcription antitermination factor activity, RNA binding
APY30_04785	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APY30_04790	COG0088	Forms part of the polypeptide exit tunnel
APY30_04795	COG0089	rRNA binding
APY30_04800	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APY30_04805	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APY30_04810	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APY30_04815	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APY30_04820	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APY30_04825	COG0255	Belongs to the universal ribosomal protein uL29 family
APY30_04830	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APY30_04835	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APY30_04840	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APY30_04845	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APY30_04850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APY30_04855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APY30_04860	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APY30_04865	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APY30_04870	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APY30_04875	COG1841	ribosomal large subunit assembly
APY30_04880	COG0200	Binds to the 23S rRNA
APY30_04885	COG0201	protein transport
APY30_04890	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APY30_04895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APY30_04900	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APY30_04905	COG0202	RNA polymerase activity
APY30_04910	COG0203	ribosomal protein L17
APY30_04915	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
APY30_04930	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
APY30_04955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APY30_04960	COG0039	L-malate dehydrogenase activity
APY30_04965	COG0625	glutathione transferase activity
APY30_04975	COG0446	pyridine nucleotide-disulphide oxidoreductase
APY30_04975	COG1902	pentaerythritol trinitrate reductase activity
APY30_04980	COG0604	alcohol dehydrogenase
APY30_05005	COG0156	8-amino-7-oxononanoate synthase activity
APY30_05010	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APY30_05015	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
APY30_05020	COG4208	sulfate ABC transporter
APY30_05025	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APY30_05035	COG1063	alcohol dehydrogenase
APY30_05060	COG0406	alpha-ribazole phosphatase activity
APY30_05065	COG0285	dihydrofolate synthase activity
APY30_05105	COG3291	Pkd domain containing protein
APY30_05115	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APY30_05120	COG0671	phosphoesterase, PA-phosphatase related
APY30_05135	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
APY30_05150	COG4783	chaperone-mediated protein folding
APY30_05165	COG0473	3-isopropylmalate dehydrogenase activity
APY30_05245	COG3179	chitinase
APY30_05290	COG4695	Portal protein
APY30_05310	COG3852	Histidine kinase
APY30_05320	COG0544	peptidyl-prolyl cis-trans isomerase activity
APY30_05325	COG0740	serine-type endopeptidase activity
APY30_05330	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APY30_05360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APY30_05370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APY30_05380	COG0328	RNA-DNA hybrid ribonuclease activity
APY30_05385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APY30_05390	COG0631	protein serine/threonine phosphatase activity
APY30_05405	COG0859	PFAM glycosyl transferase family 9
APY30_05410	COG3642	lipopolysaccharide core region biosynthetic process
APY30_05415	COG1234	tRNA 3'-trailer cleavage
APY30_05420	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APY30_05430	COG0315	cyclic pyranopterin monophosphate synthase activity
APY30_05435	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
APY30_05440	COG0314	molybdopterin synthase activity
APY30_05450	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APY30_05455	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APY30_05460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APY30_05465	COG0537	adenosine 5'-monophosphoramidase activity
APY30_05485	COG0714	Associated with various cellular activities
APY30_05505	COG0424	maF-like protein
APY30_05510	COG1399	metal-binding, possibly nucleic acid-binding protein
APY30_05515	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APY30_05520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APY30_05535	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_05540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APY30_05550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APY30_05555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APY30_05580	COG3829	transcription factor binding
APY30_05620	COG2373	Large extracellular alpha-helical protein
APY30_05635	COG4953	penicillin-binding protein 1C
APY30_05645	COG0678	peroxiredoxin activity
APY30_05665	COG0330	HflC and HflK could
APY30_05670	COG0330	HflC and HflK could
APY30_05680	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APY30_05685	COG0308	aminopeptidase N
APY30_05695	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_05700	COG1309	transcriptional regulator
APY30_05725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APY30_05730	COG1196	nuclear chromosome segregation
APY30_05740	COG2189	Belongs to the N(4) N(6)-methyltransferase family
APY30_05755	COG1309	transcriptional regulator
APY30_05760	COG0406	alpha-ribazole phosphatase activity
APY30_05760	COG0328	RNA-DNA hybrid ribonuclease activity
APY30_05765	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APY30_05780	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_05785	COG3537	Alpha-1,2-mannosidase
APY30_05790	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_05800	COG0492	ferredoxin-NADP+ reductase activity
APY30_05830	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APY30_05835	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
APY30_05840	COG2080	2 iron, 2 sulfur cluster binding
APY30_05875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APY30_05890	COG0587	DNA-directed DNA polymerase activity
APY30_05905	COG1297	OPT oligopeptide transporter protein
APY30_05920	COG1506	peptidase
APY30_05920	COG0823	Involved in the tonB-independent uptake of proteins
APY30_05950	COG2207	Transcriptional regulator
APY30_05950	COG1917	Cupin 2, conserved barrel domain protein
APY30_05985	COG0753	catalase activity
APY30_05990	COG0656	L-ascorbic acid biosynthetic process
APY30_06000	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APY30_06000	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APY30_06005	COG2814	Major facilitator Superfamily
APY30_06020	COG2194	sulfuric ester hydrolase activity
APY30_06035	COG0745	RESPONSE REGULATOR receiver
APY30_06040	COG0642	Histidine kinase
APY30_06050	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
APY30_06055	COG2894	cell division
APY30_06060	COG0850	regulation of cytokinetic process
APY30_06070	COG4585	Histidine kinase
APY30_06075	COG2197	response regulator
APY30_06090	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
APY30_06115	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
APY30_06125	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
APY30_06150	COG1946	Acyl-CoA thioesterase
APY30_06165	COG0824	Thioesterase
APY30_06170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APY30_06175	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APY30_06180	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APY30_06185	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APY30_06190	COG0268	Binds directly to 16S ribosomal RNA
APY30_06195	COG0728	peptidoglycan biosynthetic process
APY30_06200	COG0196	riboflavin kinase activity
APY30_06205	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APY30_06210	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APY30_06215	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APY30_06230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APY30_06235	COG1845	cytochrome c oxidase, subunit III
APY30_06240	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
APY30_06255	COG3152	Membrane
APY30_06265	COG2207	Transcriptional regulator
APY30_06270	COG0326	Molecular chaperone. Has ATPase activity
APY30_06280	COG1366	Belongs to the anti-sigma-factor antagonist family
APY30_06285	COG1366	Belongs to the anti-sigma-factor antagonist family
APY30_06290	COG2172	sigma factor antagonist activity
APY30_06315	COG4771	TonB-dependent receptor
APY30_06325	COG5507	3-demethylubiquinone-9 3-methyltransferase
APY30_06330	COG0745	RESPONSE REGULATOR receiver
APY30_06330	COG3706	GGDEF domain
APY30_06340	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
APY30_06345	COG3850	Histidine kinase
APY30_06345	COG4999	Histidine kinase
APY30_06345	COG2205	protein histidine kinase activity
APY30_06345	COG3437	response regulator, receiver
APY30_06350	COG4191	Histidine kinase
APY30_06350	COG0784	Response regulator, receiver
APY30_06385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APY30_06390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APY30_06400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APY30_06405	COG0228	four-way junction DNA binding
APY30_06410	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APY30_06415	COG0336	Belongs to the RNA methyltransferase TrmD family
APY30_06420	COG0335	large ribosomal subunit rRNA binding
APY30_06425	COG0534	Mate efflux family protein
APY30_06450	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
APY30_06460	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APY30_06495	COG3209	COG3209 Rhs family protein
APY30_06520	COG3250	beta-galactosidase activity
APY30_06525	COG3867	Arabinogalactan endo-beta-1,4-galactanase
APY30_06545	COG1960	acyl-CoA dehydrogenase activity
APY30_06570	COG1250	3-hydroxyacyl-CoA dehydrogenase
APY30_06570	COG1024	Enoyl-CoA hydratase
APY30_06585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APY30_06590	COG0481	GTPase activity
APY30_06605	COG0571	ribonuclease III activity
APY30_06610	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APY30_06615	COG1381	Involved in DNA repair and RecF pathway recombination
APY30_06625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APY30_06635	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
APY30_06640	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
APY30_06645	COG3046	protein related to deoxyribodipyrimidine photolyase
APY30_06650	COG1472	Belongs to the glycosyl hydrolase 3 family
APY30_06665	COG1278	Cold shock
APY30_06670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APY30_06680	COG1201	RNA secondary structure unwinding
APY30_06685	COG1793	dna ligase
APY30_06695	COG1793	dna ligase
APY30_06695	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
APY30_06710	COG0745	RESPONSE REGULATOR receiver
APY30_06710	COG3706	GGDEF domain
APY30_06725	COG0183	Belongs to the thiolase family
APY30_06745	COG1451	nucleotide metabolic process
APY30_06750	COG5487	UPF0391 membrane protein
APY30_06760	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APY30_06780	COG1077	Cell shape determining protein MreB Mrl
APY30_06785	COG1047	Peptidyl-prolyl cis-trans
APY30_06795	COG2824	Alkylphosphonate utilization operon protein PhnA
APY30_06805	COG2814	Major facilitator Superfamily
APY30_06840	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
APY30_06840	COG0392	lysyltransferase activity
APY30_06850	COG0251	oxidation-reduction process
APY30_06855	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APY30_06870	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APY30_06895	COG1595	DNA-templated transcription, initiation
APY30_06915	COG2878	Part of a membrane complex involved in electron transport
APY30_06925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APY30_06925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APY30_06940	COG1131	(ABC) transporter
APY30_06945	COG0346	lactoylglutathione lyase activity
APY30_06950	COG0833	amino acid
APY30_06955	COG2040	homocysteine
APY30_06965	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
APY30_06985	COG1695	Transcriptional regulator
APY30_07020	COG0825	malonyl-CoA metabolic process
APY30_07030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APY30_07035	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APY30_07040	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APY30_07045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APY30_07050	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APY30_07065	COG0750	zinc metalloprotease
APY30_07070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
APY30_07075	COG0575	Belongs to the CDS family
APY30_07080	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APY30_07085	COG0233	cytoplasmic translational termination
APY30_07090	COG0528	UMP kinase activity
APY30_07095	COG0745	RESPONSE REGULATOR receiver
APY30_07095	COG3706	GGDEF domain
APY30_07100	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APY30_07105	COG0052	Belongs to the universal ribosomal protein uS2 family
APY30_07140	COG0024	Methionine aminopeptidase
APY30_07145	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
APY30_07155	COG1393	Belongs to the ArsC family
APY30_07160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APY30_07165	COG0367	asparagine synthase
APY30_07175	COG4774	siderophore transport
APY30_07190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APY30_07215	COG1566	PFAM secretion protein HlyD family protein
APY30_07220	COG2814	Major facilitator Superfamily
APY30_07240	COG3104	oligopeptide transport
APY30_07270	COG0339	signal peptide processing
APY30_07275	COG0386	Belongs to the glutathione peroxidase family
APY30_07335	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APY30_07340	COG0084	hydrolase, TatD family'
APY30_07355	COG1960	acyl-CoA dehydrogenase activity
APY30_07375	COG0367	asparagine synthase
APY30_07385	COG0305	Participates in initiation and elongation during chromosome replication
APY30_07390	COG0415	Belongs to the DNA photolyase family
APY30_07400	COG0583	DNA-binding transcription factor activity
APY30_07435	COG3706	GGDEF domain
APY30_07445	COG3706	GGDEF domain
APY30_07460	COG2801	Transposase and inactivated derivatives
APY30_07500	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APY30_07515	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APY30_07525	COG0497	DNA recombination
APY30_07530	COG1420	regulation of RNA biosynthetic process
APY30_07535	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APY30_07540	COG0443	Heat shock 70 kDa protein
APY30_07545	COG0484	heat shock protein binding
APY30_07550	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
APY30_07580	COG0583	DNA-binding transcription factor activity
APY30_07585	COG1132	(ABC) transporter
APY30_07620	COG2850	peptidyl-arginine hydroxylation
APY30_07640	COG1253	flavin adenine dinucleotide binding
APY30_07670	COG1131	(ABC) transporter
APY30_07675	COG1725	Transcriptional regulator
APY30_07680	COG0386	Belongs to the glutathione peroxidase family
APY30_07695	COG2900	Belongs to the SlyX family
APY30_07720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APY30_07730	COG0646	methionine synthase
APY30_07730	COG1410	methionine synthase
APY30_07735	COG1410	methionine synthase
APY30_07735	COG0646	methionine synthase
APY30_07745	COG1960	acyl-CoA dehydrogenase activity
APY30_07760	COG0557	exoribonuclease II activity
APY30_07770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APY30_07775	COG3706	GGDEF domain
APY30_07780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APY30_07790	COG0704	Plays a role in the regulation of phosphate uptake
APY30_07795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APY30_07800	COG0581	inorganic phosphate transmembrane transporter activity
APY30_07805	COG0573	inorganic phosphate transmembrane transporter activity
APY30_07810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APY30_07835	COG0659	secondary active sulfate transmembrane transporter activity
APY30_07840	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APY30_07850	COG1024	Enoyl-CoA hydratase
APY30_07860	COG0494	nUDIX hydrolase
APY30_07900	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
APY30_07900	COG0116	Belongs to the methyltransferase superfamily
APY30_07905	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APY30_07930	COG2925	Exonuclease
APY30_07935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APY30_07940	COG3844	kynureninase activity
APY30_07950	COG0662	Cupin 2, conserved barrel domain protein
APY30_07955	COG0288	reversible hydration of carbon dioxide
APY30_08025	COG2808	Putative FMN-binding domain
APY30_08040	COG0017	Asparaginyl-tRNA synthetase
APY30_08045	COG0316	Belongs to the HesB IscA family
APY30_08050	COG0360	Binds together with S18 to 16S ribosomal RNA
APY30_08055	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APY30_08060	COG0359	binds to the 23S rRNA
APY30_08070	COG3115	cell septum assembly
APY30_08085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APY30_08090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APY30_08095	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
APY30_08105	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
APY30_08115	COG4993	Dehydrogenase
APY30_08125	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
APY30_08135	COG2986	histidine ammonia-lyase
APY30_08140	COG1228	amidohydrolase
APY30_08180	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
APY30_08185	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APY30_08190	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APY30_08195	COG0077	Prephenate dehydratase
APY30_08195	COG1605	Chorismate mutase
APY30_08200	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APY30_08215	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APY30_08220	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
APY30_08225	COG0583	DNA-binding transcription factor activity
APY30_08240	COG0840	transmembrane signaling receptor activity
APY30_08270	COG2205	protein histidine kinase activity
APY30_08270	COG5002	protein histidine kinase activity
APY30_08270	COG0784	Response regulator, receiver
APY30_08280	COG0784	Response regulator, receiver
APY30_08280	COG4191	Histidine kinase
APY30_08295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APY30_08305	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
APY30_08315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APY30_08330	COG1595	DNA-templated transcription, initiation
APY30_08355	COG2801	Transposase and inactivated derivatives
APY30_08365	COG4644	lycopene metabolic process
APY30_08370	COG2951	lytic endotransglycosylase activity
APY30_08440	COG2244	polysaccharide biosynthetic process
APY30_08470	COG2264	protein methyltransferase activity
APY30_08495	COG1136	(ABC) transporter
APY30_08500	COG1132	(ABC) transporter
APY30_08505	COG0477	Major facilitator Superfamily
APY30_08510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APY30_08525	COG1253	flavin adenine dinucleotide binding
APY30_08535	COG0306	phosphate transporter
APY30_08560	COG0504	CTP synthase activity
APY30_08565	COG2877	3-deoxy-8-phosphooctulonate synthase activity
APY30_08575	COG0148	phosphopyruvate hydratase activity
APY30_08580	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
APY30_08585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APY30_08590	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APY30_08595	COG0585	pseudouridine synthase activity
APY30_08600	COG2840	Smr protein MutS2
APY30_08605	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APY30_08610	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APY30_08615	COG1238	metal cluster binding
APY30_08630	COG1534	Rna-binding protein
APY30_08635	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
APY30_08640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APY30_08645	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APY30_08650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APY30_08655	COG1923	regulation of RNA biosynthetic process
APY30_08660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APY30_08665	COG1546	Belongs to the CinA family
APY30_08675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APY30_08680	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APY30_08685	COG2137	regulation of response to DNA damage stimulus
APY30_08690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APY30_08695	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
APY30_08710	COG1741	Belongs to the pirin family
APY30_08720	COG0583	DNA-binding transcription factor activity
APY30_08745	COG0351	phosphomethylpyrimidine kinase
APY30_08760	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
APY30_08765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APY30_08780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APY30_08790	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
APY30_08795	COG3734	2-keto-3-deoxy-galactonokinase
APY30_08805	COG4948	Mandelate Racemase Muconate Lactonizing
APY30_08810	COG0800	Aldolase
APY30_08855	COG1501	Belongs to the glycosyl hydrolase 31 family
APY30_08865	COG1070	Carbohydrate kinase
APY30_08870	COG2115	Belongs to the xylose isomerase family
APY30_08875	COG0477	Major facilitator Superfamily
APY30_08890	COG0860	N-Acetylmuramoyl-L-alanine amidase
APY30_08895	COG1469	GTP cyclohydrolase I activity
APY30_08915	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
APY30_08920	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
APY30_08925	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
APY30_08930	COG0166	Belongs to the GPI family
APY30_08950	COG1472	Belongs to the glycosyl hydrolase 3 family
APY30_08960	COG5001	Diguanylate cyclase
APY30_08960	COG4251	negative regulation of phosphorylation
APY30_08960	COG3706	GGDEF domain
APY30_08960	COG2203	Gaf domain
APY30_08965	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
APY30_08970	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
APY30_08980	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APY30_08985	COG0671	phosphoesterase, PA-phosphatase related
APY30_08995	COG1794	racemase activity, acting on amino acids and derivatives
APY30_09000	COG0697	spore germination
APY30_09005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APY30_09010	COG0167	dihydroorotate dehydrogenase activity
APY30_09025	COG1012	belongs to the aldehyde dehydrogenase family
APY30_09040	COG1215	transferase activity, transferring glycosyl groups
APY30_09045	COG0726	polysaccharide deacetylase
APY30_09045	COG1649	PFAM Uncharacterised BCR, COG1649
APY30_09090	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APY30_09100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APY30_09105	COG0124	histidyl-tRNA synthetase
APY30_09115	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APY30_09120	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APY30_09125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APY30_09130	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APY30_09130	COG0131	Imidazoleglycerol-phosphate dehydratase
APY30_09135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APY30_09140	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APY30_09145	COG0107	imidazoleglycerol-phosphate synthase activity
APY30_09150	COG0140	phosphoribosyl-ATP diphosphatase activity
APY30_09150	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APY30_09165	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
APY30_09170	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
APY30_09175	COG0235	Class ii aldolase
APY30_09180	COG0531	amino acid
APY30_09185	COG0531	amino acid
APY30_09195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APY30_09200	COG0277	FAD linked oxidase domain protein
APY30_09220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APY30_09265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APY30_09270	COG2258	MOSC domain
APY30_09275	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APY30_09280	COG0505	Belongs to the CarA family
APY30_09290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APY30_09295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APY30_09305	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APY30_09340	COG2963	transposase activity
APY30_09345	COG2801	Transposase and inactivated derivatives
APY30_09350	COG3279	Response regulator of the LytR AlgR family
APY30_09355	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APY30_09360	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APY30_09370	COG0784	Response regulator, receiver
APY30_09370	COG2198	Histidine kinase
APY30_09370	COG2205	protein histidine kinase activity
APY30_09375	COG1024	Enoyl-CoA hydratase
APY30_09380	COG0318	PFAM AMP-dependent synthetase and ligase
APY30_09410	COG2267	carboxylic ester hydrolase activity
APY30_09420	COG2201	protein-glutamate methylesterase activity
APY30_09425	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
APY30_09435	COG0840	transmembrane signaling receptor activity
APY30_09445	COG0835	chemotaxis
APY30_09455	COG0840	transmembrane signaling receptor activity
APY30_09460	COG0840	transmembrane signaling receptor activity
APY30_09465	COG0840	transmembrane signaling receptor activity
APY30_09470	COG0840	transmembrane signaling receptor activity
APY30_09495	COG0840	transmembrane signaling receptor activity
APY30_09500	COG0840	transmembrane signaling receptor activity
APY30_09505	COG0840	transmembrane signaling receptor activity
APY30_09515	COG0840	transmembrane signaling receptor activity
APY30_09520	COG0840	transmembrane signaling receptor activity
APY30_09520	COG0840	transmembrane signaling receptor activity
APY30_09530	COG0840	transmembrane signaling receptor activity
APY30_09540	COG0745	RESPONSE REGULATOR receiver
APY30_09550	COG0835	chemotaxis
APY30_09555	COG1192	Involved in chromosome partitioning
APY30_09560	COG1360	Flagellar Motor Protein
APY30_09565	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
APY30_09580	COG2801	Transposase and inactivated derivatives
APY30_09625	COG2801	Transposase and inactivated derivatives
APY30_09630	COG2963	transposase activity
APY30_09635	COG2801	Transposase and inactivated derivatives
APY30_09650	COG0643	Histidine kinase
APY30_09650	COG2198	Histidine kinase
APY30_09670	COG0455	bacterial-type flagellum organization
APY30_09680	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APY30_09695	COG5001	Diguanylate cyclase
APY30_09695	COG3300	MHYT domain
APY30_09705	COG3300	MHYT domain
APY30_09705	COG5001	Diguanylate cyclase
APY30_09710	COG1684	flagellar biosynthetic protein fliR
APY30_09715	COG1987	bacterial-type flagellum assembly
APY30_09725	COG3190	flagellar
APY30_09775	COG1677	Flagellar hook-basal body complex protein FliE
APY30_09785	COG2801	Transposase and inactivated derivatives
APY30_09825	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_09830	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_09835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APY30_09850	COG2204	response regulator
APY30_09855	COG2201	protein-glutamate methylesterase activity
APY30_09885	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
APY30_09890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APY30_09895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APY30_09905	COG1705	Flagellar rod assembly protein muramidase FlgJ
APY30_09905	COG3951	Flagellar rod assembly protein muramidase FlgJ
APY30_09910	COG1706	bacterial-type flagellum-dependent cell motility
APY30_09915	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
APY30_09920	COG4786	Flagellar basal body rod
APY30_09925	COG4787	bacterial-type flagellum-dependent cell motility
APY30_09930	COG1749	Flagellar hook protein flgE
APY30_09935	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
APY30_09940	COG1558	bacterial-type flagellum-dependent cell motility
APY30_09945	COG1815	bacterial-type flagellum-dependent cell motility
APY30_09950	COG0835	chemotaxis
APY30_09950	COG0784	Response regulator, receiver
APY30_09970	COG5002	protein histidine kinase activity
APY30_10000	COG2915	High frequency lysogenization protein hflD homolog
APY30_10005	COG0482	sulfurtransferase activity
APY30_10015	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
APY30_10020	COG0542	response to heat
APY30_10025	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APY30_10030	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
APY30_10040	COG0492	ferredoxin-NADP+ reductase activity
APY30_10045	COG1674	ftsk spoiiie
APY30_10055	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
APY30_10065	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APY30_10070	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APY30_10075	COG0183	Belongs to the thiolase family
APY30_10080	COG1024	Enoyl-CoA hydratase
APY30_10080	COG1250	3-hydroxyacyl-CoA dehydrogenase
APY30_10090	COG0105	UTP biosynthetic process
APY30_10095	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APY30_10105	COG1426	Protein conserved in bacteria
APY30_10115	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APY30_10120	COG1160	GTP binding
APY30_10125	COG0303	'Molybdopterin
APY30_10130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APY30_10280	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APY30_10305	COG4456	Virulence-associated protein
APY30_10345	COG4644	lycopene metabolic process
APY30_10400	COG2801	Transposase and inactivated derivatives
APY30_10405	COG2963	transposase activity
APY30_10430	COG2801	Transposase and inactivated derivatives
APY30_10445	COG0708	Exodeoxyribonuclease III
APY30_10455	COG0303	'Molybdopterin
APY30_10460	COG0746	molybdenum cofactor guanylyltransferase activity
APY30_10470	COG1648	precorrin-2 dehydrogenase activity
APY30_10470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APY30_10490	COG3685	Protein conserved in bacteria
APY30_10505	COG5001	Diguanylate cyclase
APY30_10515	COG4566	intracellular signal transduction
APY30_10535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APY30_10560	COG3279	Response regulator of the LytR AlgR family
APY30_10590	COG1238	metal cluster binding
APY30_10635	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
APY30_10635	COG0316	Belongs to the HesB IscA family
APY30_10640	COG2154	pterin-4-alpha-carbinolamine dehydratase
APY30_10650	COG0428	transporter
APY30_10655	COG3064	Membrane
APY30_10665	COG1530	ribonuclease E activity
APY30_10695	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
APY30_10770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APY30_10795	COG1192	Involved in chromosome partitioning
APY30_10830	COG0629	single-stranded DNA binding
APY30_10835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APY30_10840	COG0270	DNA (cytosine-5-)-methyltransferase activity
APY30_10905	COG2826	transposase and inactivated derivatives, IS30 family
APY30_11030	COG0583	DNA-binding transcription factor activity
APY30_11035	COG0477	Major facilitator Superfamily
APY30_11140	COG3593	DNA synthesis involved in DNA repair
APY30_11145	COG1074	ATP-dependent DNA helicase activity
APY30_11155	COG0583	DNA-binding transcription factor activity
APY30_11160	COG0582	viral genome integration into host DNA
APY30_11180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APY30_11185	COG0322	excinuclease ABC activity
APY30_11195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APY30_11200	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APY30_11205	COG1663	tetraacyldisaccharide 4'-kinase activity
APY30_11210	COG1132	(ABC) transporter
APY30_11220	COG0811	peptide transport
APY30_11235	COG1136	(ABC) transporter
APY30_11240	COG4591	ABC-type transport system involved in lipoprotein release permease component
APY30_11250	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
APY30_11255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APY30_11270	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
APY30_11290	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APY30_11295	COG0837	glucose binding
APY30_11300	COG0363	glucosamine-6-phosphate deaminase activity
APY30_11305	COG0129	dihydroxy-acid dehydratase activity
APY30_11310	COG0800	Aldolase
APY30_11315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APY30_11320	COG2963	transposase activity
APY30_11325	COG2801	Transposase and inactivated derivatives
APY30_11390	COG2205	protein histidine kinase activity
APY30_11390	COG0784	Response regulator, receiver
APY30_11395	COG2183	response to ionizing radiation
APY30_11405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APY30_11405	COG0723	plastoquinol--plastocyanin reductase activity
APY30_11420	COG3243	poly(R)-hydroxyalkanoic acid synthase
APY30_11430	COG1183	phosphatidylcholine synthase activity
APY30_11435	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_11450	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
APY30_11460	COG0668	transmembrane transport
APY30_11470	COG2814	Major facilitator Superfamily
APY30_11490	COG1914	H( )-stimulated, divalent metal cation uptake system
APY30_11495	COG1321	iron dependent repressor
APY30_11500	COG0590	tRNA wobble adenosine to inosine editing
APY30_11505	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
APY30_11515	COG1335	isochorismatase
APY30_11530	COG2197	response regulator
APY30_11550	COG0583	DNA-binding transcription factor activity
APY30_11555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APY30_11560	COG3002	Belongs to the UPF0753 family
APY30_11585	COG3846	protein secretion by the type IV secretion system
APY30_11600	COG3451	type IV secretory pathway VirB4
APY30_11615	COG4962	Type ii secretion system protein e
APY30_11630	COG2801	Transposase and inactivated derivatives
APY30_11650	COG0667	Aldo Keto reductase
APY30_11700	COG0582	viral genome integration into host DNA
APY30_11705	COG0519	Catalyzes the synthesis of GMP from XMP
APY30_11705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APY30_11715	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APY30_11725	COG0475	glutathione-regulated potassium exporter activity
APY30_11725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APY30_11730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APY30_11740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APY30_11745	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
APY30_11755	COG0776	regulation of translation
APY30_11760	COG0539	negative regulation of cytoplasmic translation
APY30_11765	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APY30_11770	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APY30_11780	COG2957	Belongs to the agmatine deiminase family
APY30_11785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APY30_11810	COG0395	ABC-type sugar transport system, permease component
APY30_11815	COG1175	transmembrane transport
APY30_11845	COG2350	Protein conserved in bacteria
APY30_11850	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
APY30_11855	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APY30_11860	COG1187	pseudouridine synthase activity
APY30_11880	COG0436	Aminotransferase
APY30_11885	COG4133	protoheme IX ABC transporter activity
APY30_11905	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
APY30_11910	COG1138	Cytochrome C-type biogenesis protein
APY30_11930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APY30_11935	COG1278	Cold shock
APY30_11940	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APY30_11945	COG4988	ABC transporter
APY30_11955	COG1294	oxidase, subunit
APY30_11975	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APY30_11980	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APY30_11990	COG0165	Argininosuccinate lyase
APY30_11995	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APY30_12005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APY30_12020	COG0137	argininosuccinate synthase activity
APY30_12025	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APY30_12035	COG0215	cysteine-tRNA ligase activity
APY30_12040	COG2166	iron-sulfur cluster assembly
APY30_12050	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APY30_12060	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
APY30_12065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APY30_12090	COG4302	ethanolamine ammonia-lyase activity
APY30_12120	COG2801	Transposase and inactivated derivatives
APY30_12130	COG2801	Transposase and inactivated derivatives
APY30_12150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APY30_12155	COG0402	S-adenosylhomocysteine deaminase activity
APY30_12165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APY30_12170	COG1509	lysine 2,3-aminomutase activity
APY30_12175	COG5001	Diguanylate cyclase
APY30_12175	COG3300	MHYT domain
APY30_12190	COG0483	inositol monophosphate 1-phosphatase activity
APY30_12215	COG0513	Belongs to the DEAD box helicase family
APY30_12220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APY30_12225	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
APY30_12235	COG0625	glutathione transferase activity
APY30_12245	COG4681	YaeQ
APY30_12250	COG2081	HI0933 family
APY30_12260	COG0501	Belongs to the peptidase M48B family
APY30_12265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APY30_12270	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_12290	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APY30_12295	COG0860	N-Acetylmuramoyl-L-alanine amidase
APY30_12300	COG0802	atpase or kinase
APY30_12305	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APY30_12305	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APY30_12310	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APY30_12315	COG1570	exodeoxyribonuclease VII activity
APY30_12325	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APY30_12375	COG2801	Transposase and inactivated derivatives
APY30_12420	COG2801	Transposase and inactivated derivatives
APY30_12450	COG0835	chemotaxis
APY30_12455	COG0840	transmembrane signaling receptor activity
APY30_12460	COG2094	Belongs to the DNA glycosylase MPG family
APY30_12465	COG1201	RNA secondary structure unwinding
APY30_12480	COG2969	positive regulation of protein catabolic process
APY30_12485	COG0625	glutathione transferase activity
APY30_12490	COG2857	Cytochrome c1
APY30_12495	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APY30_12500	COG0723	plastoquinol--plastocyanin reductase activity
APY30_12505	COG0741	lytic transglycosylase activity
APY30_12520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APY30_12525	COG1702	phosphate starvation-inducible protein PhoH
APY30_12535	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APY30_12545	COG4535	Mg2 and Co2 transporter CorC
APY30_12560	COG1012	belongs to the aldehyde dehydrogenase family
APY30_12570	COG1177	transmembrane transport
APY30_12575	COG1176	ABC-type spermidine putrescine transport system, permease component I
APY30_12600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APY30_12615	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
APY30_12620	COG0174	glutamine synthetase
APY30_12625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APY30_12630	COG0745	RESPONSE REGULATOR receiver
APY30_12630	COG3706	GGDEF domain
APY30_12635	COG2703	oxygen carrier activity
APY30_12640	COG0477	Major facilitator Superfamily
APY30_12650	COG0243	molybdopterin cofactor binding
APY30_12655	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
APY30_12680	COG2733	membrane
APY30_12685	COG2205	protein histidine kinase activity
APY30_12685	COG5002	protein histidine kinase activity
APY30_12685	COG0784	Response regulator, receiver
APY30_12695	COG0477	Major facilitator Superfamily
APY30_12700	COG2902	Dehydrogenase
APY30_12710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APY30_12715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APY30_12720	COG1609	Transcriptional regulator
APY30_12725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APY30_12725	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APY30_12730	COG1105	Belongs to the carbohydrate kinase PfkB family
APY30_12735	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APY30_12735	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APY30_12755	COG2801	Transposase and inactivated derivatives
APY30_12790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APY30_12800	COG1862	Preprotein translocase
APY30_12805	COG0343	queuine tRNA-ribosyltransferase activity
APY30_12810	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APY30_12835	COG2801	Transposase and inactivated derivatives
APY30_12860	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APY30_12865	COG3291	Pkd domain containing protein
APY30_12875	COG0405	Gamma-glutamyltransferase
APY30_12880	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APY30_12895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APY30_12900	COG0742	ribosomal rna small subunit methyltransferase
APY30_12905	COG0326	Molecular chaperone. Has ATPase activity
APY30_12940	COG4206	TonB-dependent receptor
APY30_12995	COG0531	amino acid
APY30_13010	COG0006	proline dipeptidase activity
APY30_13020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APY30_13035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APY30_13040	COG3938	Belongs to the proline racemase family
APY30_13050	COG0552	protein localization to endoplasmic reticulum
APY30_13055	COG1194	a g-specific adenine glycosylase
APY30_13060	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
APY30_13065	COG0784	Response regulator, receiver
APY30_13065	COG4191	Histidine kinase
APY30_13080	COG0322	excinuclease ABC activity
APY30_13095	COG3040	lipid binding
APY30_13105	COG1960	acyl-CoA dehydrogenase activity
APY30_13115	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APY30_13135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APY30_13140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APY30_13145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APY30_13180	COG0438	transferase activity, transferring glycosyl groups
APY30_13185	COG0438	transferase activity, transferring glycosyl groups
APY30_13230	COG0776	regulation of translation
APY30_13235	COG0072	phenylalanine-tRNA ligase activity
APY30_13235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APY30_13240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APY30_13245	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APY30_13250	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APY30_13255	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APY30_13260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APY30_13345	COG2948	multi-organism process
APY30_13365	COG3505	Type IV secretory pathway VirD4
APY30_13380	COG0556	nucleotide-excision repair
APY30_13420	COG1611	Belongs to the LOG family
APY30_13430	COG2095	MarC family integral membrane protein
APY30_13440	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APY30_13445	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APY30_13475	COG1185	polyribonucleotide nucleotidyltransferase activity
APY30_13480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APY30_13485	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APY30_13490	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APY30_13495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APY30_13500	COG0195	Participates in both transcription termination and antitermination
APY30_13505	COG0779	Required for maturation of 30S ribosomal subunits
APY30_13515	COG1007	ATP synthesis coupled electron transport
APY30_13530	COG0713	ATP synthesis coupled electron transport
APY30_13540	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APY30_13545	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
APY30_13555	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
APY30_13560	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
APY30_13565	COG0649	NAD binding
APY30_13570	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APY30_13575	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APY30_13580	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APY30_13595	COG0149	triose-phosphate isomerase activity
APY30_13600	COG0300	oxidoreductase activity
APY30_13635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APY30_13640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APY30_13645	COG0159	tryptophan synthase activity
APY30_13655	COG0133	tryptophan synthase activity
APY30_13665	COG0135	phosphoribosylanthranilate isomerase activity
APY30_13670	COG0101	tRNA pseudouridine synthase activity
APY30_13690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APY30_13695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APY30_13700	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APY30_13705	COG2890	protein-(glutamine-N5) methyltransferase activity
APY30_13715	COG0688	phosphatidylethanolamine metabolic process
APY30_13745	COG0433	COG0433 Predicted ATPase
APY30_13750	COG0494	nUDIX hydrolase
APY30_13765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APY30_13770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APY30_13780	COG2336	PFAM SpoVT AbrB
APY30_13795	COG1404	Belongs to the peptidase S8 family
APY30_13810	COG2801	Transposase and inactivated derivatives
APY30_13840	COG0717	Belongs to the dCTP deaminase family
APY30_13845	COG0489	protein tyrosine kinase activity
APY30_13865	COG3590	peptidase
APY30_13870	COG3590	peptidase
APY30_13890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APY30_13895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APY30_13900	COG2311	Membrane
APY30_13905	COG1047	Peptidyl-prolyl cis-trans
APY30_13910	COG0791	NLP P60 protein
APY30_13915	COG0791	NLP P60 protein
APY30_13925	COG4106	trans-aconitate 2-methyltransferase activity
APY30_13930	COG1301	dicarboxylic acid transport
APY30_13935	COG1785	Belongs to the alkaline phosphatase family
APY30_13945	COG0037	tRNA processing
APY30_13950	COG1722	exodeoxyribonuclease VII activity
APY30_13955	COG0142	geranyltranstransferase activity
APY30_13960	COG4104	PAAR repeat-containing protein
APY30_13970	COG0312	modulator of DNA gyrase
APY30_13975	COG3028	Belongs to the UPF0307 family
APY30_13980	COG0312	modulator of DNA gyrase
APY30_13990	COG3164	Protein of unknown function
APY30_13995	COG1530	ribonuclease E activity
APY30_14000	COG0424	maF-like protein
APY30_14005	COG2968	Membrane
APY30_14020	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APY30_14035	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APY30_14050	COG0495	leucyl-tRNA aminoacylation
APY30_14060	COG3118	belongs to the thioredoxin family
APY30_14095	COG2155	Conserved Protein
APY30_14100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APY30_14140	COG1132	(ABC) transporter
APY30_14165	COG1538	Outer membrane efflux protein
APY30_14170	COG0745	RESPONSE REGULATOR receiver
APY30_14180	COG0475	glutathione-regulated potassium exporter activity
APY30_14185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
APY30_14190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APY30_14210	COG3706	GGDEF domain
APY30_14210	COG0745	RESPONSE REGULATOR receiver
APY30_14215	COG1187	pseudouridine synthase activity
APY30_14220	COG5001	Diguanylate cyclase
APY30_14220	COG5002	protein histidine kinase activity
APY30_14340	COG2814	Major facilitator Superfamily
APY30_14345	COG0583	DNA-binding transcription factor activity
APY30_14355	COG2207	Transcriptional regulator
APY30_14370	COG0667	Aldo Keto reductase
APY30_14375	COG1309	transcriptional regulator
APY30_14380	COG1538	Outer membrane efflux protein
APY30_14385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APY30_14400	COG0735	belongs to the Fur family
APY30_14405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APY30_14430	COG4452	Inner membrane protein CreD
APY30_14445	COG2205	protein histidine kinase activity
APY30_14450	COG0745	RESPONSE REGULATOR receiver
APY30_14455	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APY30_14465	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APY30_14495	COG0643	Histidine kinase
APY30_14495	COG2198	Histidine kinase
APY30_14500	COG0840	transmembrane signaling receptor activity
APY30_14505	COG0835	chemotaxis
APY30_14510	COG2200	EAL domain
APY30_14510	COG2202	Pas domain
APY30_14510	COG2199	diguanylate cyclase activity
APY30_14515	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
APY30_14520	COG2201	protein-glutamate methylesterase activity
APY30_14525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APY30_14530	COG3590	peptidase
APY30_14540	COG0588	phosphoglycerate mutase activity
APY30_14545	COG1515	deoxyribonuclease V activity
APY30_14555	COG1741	Belongs to the pirin family
APY30_14570	COG1741	Belongs to the pirin family
APY30_14575	COG1966	Carbon starvation protein
APY30_14580	COG2879	small protein
APY30_14625	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APY30_14635	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
APY30_14640	COG2080	2 iron, 2 sulfur cluster binding
APY30_14645	COG3321	synthase
APY30_14645	COG0604	alcohol dehydrogenase
APY30_14645	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_14650	COG3706	GGDEF domain
APY30_14650	COG4251	negative regulation of phosphorylation
APY30_14650	COG2203	Gaf domain
APY30_14650	COG5001	Diguanylate cyclase
APY30_14655	COG0629	single-stranded DNA binding
APY30_14660	COG0142	geranyltranstransferase activity
APY30_14670	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APY30_14685	COG0527	aspartate kinase activity
APY30_14690	COG0384	phenazine biosynthesis protein PhzF
APY30_14695	COG0384	phenazine biosynthesis protein PhzF
APY30_14705	COG1764	response to oxidative stress
APY30_14710	COG0540	Belongs to the ATCase OTCase family
APY30_14715	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APY30_14720	COG1678	Uncharacterized ACR, COG1678
APY30_14730	COG0519	Catalyzes the synthesis of GMP from XMP
APY30_14755	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APY30_14770	COG0739	heme binding
APY30_14790	COG0693	protein deglycase activity
APY30_14800	COG1959	2 iron, 2 sulfur cluster binding
APY30_14805	COG0719	Fe-S assembly protein
APY30_14810	COG0396	ATPase activity
APY30_14815	COG0719	Fe-S assembly protein
APY30_14820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APY30_14835	COG4774	siderophore transport
APY30_14840	COG3128	pkhd-type hydroxylase
APY30_14865	COG1477	protein flavinylation
APY30_14870	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
APY30_14885	COG1555	photosystem II stabilization
APY30_14900	COG3178	'Phosphotransferase
APY30_14905	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APY30_14915	COG0628	permease
APY30_14925	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APY30_14940	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APY30_14960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APY30_14965	COG0271	Belongs to the BolA IbaG family
APY30_14975	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
APY30_14985	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
APY30_14990	COG1137	ATPase activity
APY30_15005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APY30_15010	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
APY30_15015	COG1660	Displays ATPase and GTPase activities
APY30_15025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APY30_15030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APY30_15035	COG2239	Acts as a magnesium transporter
APY30_15045	COG1294	oxidase, subunit
APY30_15050	COG1271	oxidase subunit
APY30_15060	COG1113	amino acid transport
APY30_15070	COG2963	transposase activity
APY30_15075	COG2801	Transposase and inactivated derivatives
APY30_15095	COG2197	response regulator
APY30_15100	COG0531	amino acid
APY30_15190	COG0754	glutathionylspermidine amidase activity
APY30_15215	COG1842	Phage shock protein A
APY30_15225	COG0259	pyridoxamine-phosphate oxidase activity
APY30_15230	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APY30_15235	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APY30_15245	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APY30_15265	COG0784	Response regulator, receiver
APY30_15265	COG2198	Histidine kinase
APY30_15265	COG5002	protein histidine kinase activity
APY30_15270	COG0784	Response regulator, receiver
APY30_15270	COG2205	protein histidine kinase activity
APY30_15270	COG2198	Histidine kinase
APY30_15275	COG2353	YceI-like domain
APY30_15295	COG1760	l-serine dehydratase
APY30_15305	COG0460	homoserine dehydrogenase
APY30_15305	COG0527	aspartate kinase activity
APY30_15310	COG0626	cystathionine gamma-synthase activity
APY30_15315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APY30_15320	COG0739	heme binding
APY30_15325	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
APY30_15330	COG1272	protein, Hemolysin III
APY30_15335	COG2982	Protein involved in outer membrane biogenesis
APY30_15340	COG0516	GMP reductase activity
APY30_15340	COG0517	IMP dehydrogenase activity
APY30_15345	COG0463	Glycosyl transferase, family 2
APY30_15350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APY30_15355	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
APY30_15365	COG4771	TonB-dependent receptor
APY30_15370	COG2801	Transposase and inactivated derivatives
APY30_15380	COG2963	transposase activity
APY30_15385	COG2801	Transposase and inactivated derivatives
APY30_15405	COG1309	transcriptional regulator
APY30_15410	COG2267	carboxylic ester hydrolase activity
APY30_15415	COG1960	acyl-CoA dehydrogenase activity
APY30_15445	COG0509	glycine decarboxylation via glycine cleavage system
APY30_15450	COG0404	The glycine cleavage system catalyzes the degradation of glycine
APY30_15460	COG1742	UPF0060 membrane protein
APY30_15465	COG3956	TIGRFAM MazG family protein
APY30_15475	COG0494	nUDIX hydrolase
APY30_15485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APY30_15490	COG0837	glucose binding
APY30_15505	COG3858	chitin binding
APY30_15505	COG1388	LysM domain
APY30_15510	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APY30_15520	COG1472	Belongs to the glycosyl hydrolase 3 family
APY30_15555	COG3537	Alpha-1,2-mannosidase
APY30_15590	COG3142	Participates in the control of copper homeostasis
APY30_15595	COG1446	asparaginase
APY30_15625	COG0840	transmembrane signaling receptor activity
APY30_15630	COG0835	chemotaxis
APY30_15645	COG0189	ligase activity
APY30_15655	COG1397	ADP-ribosylglycohydrolase
APY30_15665	COG1199	ATP-dependent helicase activity
APY30_15675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APY30_15680	COG1215	transferase activity, transferring glycosyl groups
APY30_15690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APY30_15695	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
APY30_15700	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
APY30_15705	COG0535	radical SAM domain protein
APY30_15710	COG0535	radical SAM domain protein
APY30_15725	COG0837	glucose binding
APY30_15735	COG1643	Atp-dependent helicase
APY30_15740	COG0783	Belongs to the Dps family
APY30_15745	COG0514	ATP-dependent DNA helicase (RecQ)
APY30_15780	COG0840	transmembrane signaling receptor activity
APY30_15800	COG3920	Histidine kinase
APY30_15805	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APY30_15815	COG0602	queuosine metabolic process
APY30_15825	COG2885	chlorophyll binding
APY30_15830	COG0823	Involved in the tonB-independent uptake of proteins
APY30_15840	COG0848	biopolymer transport protein
APY30_15850	COG0824	Thioesterase
APY30_15855	COG2255	four-way junction helicase activity
APY30_15865	COG3158	transport of potassium into the cell
APY30_15870	COG0632	four-way junction helicase activity
APY30_15875	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
APY30_15880	COG0217	transcriptional regulatory protein
APY30_15895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APY30_15910	COG0477	Major facilitator Superfamily
APY30_15940	COG0488	(ABC) transporter
APY30_15975	COG4651	solute:proton antiporter activity
APY30_15975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APY30_16000	COG4772	TonB-dependent receptor
APY30_16010	COG4264	IucA IucC family
APY30_16025	COG0019	diaminopimelate decarboxylase activity
APY30_16045	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
APY30_16055	COG1492	cobalamin metabolic process
APY30_16065	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
APY30_16085	COG4206	TonB-dependent receptor
APY30_16090	COG0542	response to heat
APY30_16095	COG1116	anion transmembrane transporter activity
APY30_16100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APY30_16105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APY30_16110	COG0667	Aldo Keto reductase
APY30_16120	COG4771	TonB-dependent receptor
APY30_16125	COG2827	Endonuclease containing a URI domain
APY30_16165	COG1877	trehalose-phosphatase activity
APY30_16170	COG3387	PFAM Glycoside hydrolase 15-related
APY30_16185	COG0840	transmembrane signaling receptor activity
APY30_16190	COG3011	Protein conserved in bacteria
APY30_16205	COG0564	pseudouridine synthase activity
APY30_16210	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APY30_16220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APY30_16220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
APY30_16235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APY30_16240	COG0045	succinate-CoA ligase (ADP-forming) activity
APY30_16280	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
APY30_16285	COG0237	dephospho-CoA kinase activity
APY30_16305	COG2801	Transposase and inactivated derivatives
APY30_16310	COG2963	transposase activity
APY30_16320	COG5002	protein histidine kinase activity
APY30_16325	COG0745	RESPONSE REGULATOR receiver
APY30_16335	COG0189	ligase activity
APY30_16425	COG2003	Belongs to the UPF0758 family
APY30_16430	COG1196	nuclear chromosome segregation
APY30_16455	COG4133	protoheme IX ABC transporter activity
APY30_16490	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
APY30_16495	COG0631	protein serine/threonine phosphatase activity
APY30_16500	COG4245	von Willebrand factor, type A
APY30_16520	COG3209	COG3209 Rhs family protein
APY30_16550	COG2022	thiamine diphosphate biosynthetic process
APY30_16555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APY30_16560	COG0471	metal ion transport
APY30_16560	COG3273	potassium ion transport
APY30_16580	COG1970	mechanosensitive ion channel activity
APY30_16595	COG1609	Transcriptional regulator
APY30_16620	COG3250	beta-galactosidase activity
APY30_16625	COG4948	Mandelate Racemase Muconate Lactonizing
APY30_16640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APY30_16650	COG0308	aminopeptidase N
APY30_16665	COG2801	Transposase and inactivated derivatives
APY30_16680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APY30_16690	COG0529	Catalyzes the synthesis of activated sulfate
APY30_16690	COG2895	sulfate adenylyltransferase (ATP) activity
APY30_16695	COG0175	sulfate reduction
APY30_16700	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
APY30_16705	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APY30_16710	COG0175	sulfate reduction
APY30_16750	COG1648	precorrin-2 dehydrogenase activity
APY30_16750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APY30_16765	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
APY30_16770	COG3588	fructose-bisphosphate aldolase
APY30_16775	COG0469	pyruvate kinase activity
APY30_16785	COG0126	phosphoglycerate kinase activity
APY30_16805	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APY30_16815	COG3047	cAMP biosynthetic process
APY30_16820	COG3047	cAMP biosynthetic process
APY30_16830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APY30_16830	COG3453	Protein conserved in bacteria
APY30_16835	COG0725	ABC transporter, periplasmic molybdate-binding protein
APY30_16840	COG4149	molybdate abc transporter
APY30_16845	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
APY30_16900	COG4773	Receptor
APY30_16920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APY30_16925	COG1301	dicarboxylic acid transport
APY30_16935	COG2304	oxidoreductase activity
APY30_16955	COG0714	Associated with various cellular activities
APY30_16985	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APY30_17000	COG0254	rRNA binding
APY30_17010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APY30_17020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APY30_17025	COG1758	RNA polymerase activity
APY30_17030	COG0194	GDP metabolic process
APY30_17035	COG1561	YicC-like family, N-terminal region
APY30_17040	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
APY30_17050	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APY30_17055	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APY30_17070	COG0006	proline dipeptidase activity
APY30_17080	COG0006	proline dipeptidase activity
APY30_17085	COG3079	Belongs to the UPF0149 family
APY30_17100	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APY30_17110	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APY30_17120	COG2912	Transglutaminase-like superfamily
APY30_17125	COG1773	rubredoxin
APY30_17130	COG0352	thiamine-phosphate diphosphorylase activity
APY30_17140	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APY30_17155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APY30_17185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APY30_17190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APY30_17195	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_17205	COG0671	phosphoesterase, PA-phosphatase related
APY30_17210	COG3781	membrane
APY30_17220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APY30_17225	COG0563	adenylate kinase activity
APY30_17250	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
APY30_17260	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APY30_17280	COG3710	Transcriptional regulator
APY30_17285	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
APY30_17295	COG0840	transmembrane signaling receptor activity
APY30_17300	COG0405	Gamma-glutamyltransferase
APY30_17305	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APY30_17325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APY30_17330	COG0473	3-isopropylmalate dehydrogenase activity
APY30_17335	COG0066	3-isopropylmalate dehydratase activity
APY30_17340	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APY30_17360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APY30_17365	COG1538	Outer membrane efflux protein
APY30_17370	COG1519	Transferase
APY30_17375	COG1560	Kdo2-lipid A biosynthetic process
APY30_17400	COG0281	malic enzyme
APY30_17400	COG0280	phosphate acetyltransferase
APY30_17405	COG1301	dicarboxylic acid transport
APY30_17435	COG0583	DNA-binding transcription factor activity
APY30_17445	COG0667	Aldo Keto reductase
APY30_17460	COG2197	response regulator
APY30_17465	COG1840	ABC-type Fe3 transport system, periplasmic component
APY30_17470	COG0642	Histidine kinase
APY30_17485	COG2851	Citrate transporter
APY30_17490	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_17495	COG1609	Transcriptional regulator
APY30_17500	COG2211	Major facilitator Superfamily
APY30_17525	COG1162	GTPase activity
APY30_17545	COG0318	PFAM AMP-dependent synthetase and ligase
APY30_17550	COG0583	DNA-binding transcription factor activity
APY30_17555	COG3384	dioxygenase
APY30_17585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APY30_17590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APY30_17600	COG2096	Adenosyltransferase
APY30_17605	COG0123	including yeast histone deacetylase and acetoin utilization protein
APY30_17615	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
APY30_17620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APY30_17625	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APY30_17630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APY30_17635	COG2967	ApaG domain
APY30_17640	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APY30_17660	COG0747	negative chemotaxis
APY30_17685	COG0431	NADPH-dependent FMN reductase
APY30_17690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APY30_17700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APY30_17705	COG1116	anion transmembrane transporter activity
APY30_17715	COG3829	transcription factor binding
APY30_17730	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
APY30_17735	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APY30_17755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APY30_17780	COG4181	ATPase activity
APY30_17790	COG2175	clavaminate synthase activity
APY30_17800	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
APY30_17805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APY30_17825	COG4771	TonB-dependent receptor
APY30_17835	COG0667	Aldo Keto reductase
APY30_17840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APY30_17845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APY30_17855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APY30_17860	COG4106	trans-aconitate 2-methyltransferase activity
APY30_17870	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APY30_17905	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APY30_17915	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
APY30_17950	COG0366	Alpha amylase catalytic
APY30_17975	COG0604	alcohol dehydrogenase
APY30_17975	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_17975	COG3321	synthase
APY30_17985	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
APY30_17995	COG0494	nUDIX hydrolase
APY30_18000	COG0653	protein targeting
APY30_18005	COG0739	heme binding
APY30_18015	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
APY30_18030	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
APY30_18035	COG1181	Belongs to the D-alanine--D-alanine ligase family
APY30_18040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APY30_18045	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APY30_18055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APY30_18060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APY30_18065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APY30_18075	COG3116	cell division
APY30_18080	COG0275	rRNA processing
APY30_18085	COG2001	Belongs to the MraZ family
APY30_18110	COG0792	nuclease activity
APY30_18115	COG1988	membrane-bound metal-dependent
APY30_18120	COG0277	FAD linked oxidase domain protein
APY30_18135	COG0745	RESPONSE REGULATOR receiver
APY30_18140	COG2205	protein histidine kinase activity
APY30_18145	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
APY30_18150	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
APY30_18155	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
APY30_18175	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APY30_18180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APY30_18185	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APY30_18215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APY30_18215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APY30_18225	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APY30_18230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APY30_18240	COG0488	(ABC) transporter
APY30_18250	COG0697	spore germination
APY30_18260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APY30_18275	COG3791	Glutathione-dependent formaldehyde-activating
APY30_18300	COG0745	RESPONSE REGULATOR receiver
APY30_18305	COG2205	protein histidine kinase activity
APY30_18325	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APY30_18340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APY30_18350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APY30_18355	COG1012	belongs to the aldehyde dehydrogenase family
APY30_18360	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
APY30_18365	COG0617	tRNA 3'-terminal CCA addition
APY30_18375	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APY30_18380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APY30_18385	COG1609	Transcriptional regulator
APY30_18410	COG3250	beta-galactosidase activity
APY30_18440	COG4795	General secretion pathway protein
APY30_18460	COG1459	type II secretion system
APY30_18510	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_18515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APY30_18520	COG4191	Histidine kinase
APY30_18525	COG0784	Response regulator, receiver
APY30_18530	COG4251	negative regulation of phosphorylation
APY30_18535	COG2823	Periplasmic or secreted lipoprotein
APY30_18540	COG0673	inositol 2-dehydrogenase activity
APY30_18545	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
APY30_18580	COG1051	belongs to the nudix hydrolase family
APY30_18580	COG1056	cytidyltransferase-related domain
APY30_18590	COG0583	DNA-binding transcription factor activity
APY30_18605	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APY30_18610	COG0321	lipoyl(octanoyl) transferase activity
APY30_18615	COG2921	Belongs to the UPF0250 family
APY30_18625	COG1686	Belongs to the peptidase S11 family
APY30_18635	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APY30_18640	COG2951	lytic endotransglycosylase activity
APY30_18650	COG0772	Belongs to the SEDS family
APY30_18665	COG1792	Involved in formation and maintenance of cell shape
APY30_18670	COG1077	Cell shape determining protein MreB Mrl
APY30_18680	COG3284	Transcriptional regulator
APY30_18690	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
APY30_18730	COG0308	aminopeptidase N
APY30_18735	COG3300	MHYT domain
APY30_18735	COG5001	Diguanylate cyclase
APY30_18740	COG2226	methyltransferase
APY30_18765	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
APY30_18770	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
APY30_18775	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
APY30_18790	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APY30_18800	COG2832	Protein of unknown function (DUF454)
APY30_18810	COG0436	Aminotransferase
APY30_18820	COG1505	serine-type exopeptidase activity
APY30_18845	COG0181	hydroxymethylbilane synthase activity
APY30_18855	COG3275	phosphorelay sensor kinase activity
APY30_18865	COG2943	transferase activity, transferring hexosyl groups
APY30_18880	COG3706	GGDEF domain
APY30_18885	COG0659	secondary active sulfate transmembrane transporter activity
APY30_18890	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
APY30_18890	COG5297	Belongs to the glycosyl hydrolase family 6
APY30_18895	COG0840	transmembrane signaling receptor activity
APY30_18900	COG5001	Diguanylate cyclase
APY30_18935	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
APY30_18945	COG0598	Magnesium transport protein CorA
APY30_18955	COG1113	amino acid transport
APY30_18970	COG0697	spore germination
APY30_18990	COG3706	GGDEF domain
APY30_19005	COG1506	peptidase
APY30_19005	COG0823	Involved in the tonB-independent uptake of proteins
APY30_19010	COG2409	Drug exporters of the RND superfamily
APY30_19045	COG0435	Glutathione S-transferase
APY30_19055	COG4221	oxidoreductase activity
APY30_19070	COG4221	oxidoreductase activity
APY30_19145	COG0546	phosphoglycolate phosphatase activity
APY30_19150	COG1802	Transcriptional regulator
APY30_19160	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APY30_19165	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
APY30_19185	COG3052	prosthetic group binding
APY30_19215	COG2353	YceI-like domain
APY30_19220	COG0778	Nitroreductase
APY30_19240	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
APY30_19245	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
APY30_19255	COG3386	PFAM SMP-30 Gluconolaconase
APY30_19270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APY30_19285	COG0459	protein refolding
APY30_19290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APY30_19295	COG2356	endonuclease I
APY30_19300	COG0300	oxidoreductase activity
APY30_19325	COG1324	tolerance protein
APY30_19335	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APY30_19340	COG0511	ligase activity, forming carbon-carbon bonds
APY30_19350	COG0439	Biotin carboxylase
APY30_19375	COG2264	protein methyltransferase activity
APY30_19400	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
APY30_19405	COG4589	Belongs to the CDS family
APY30_19430	COG2453	phosphatase
APY30_19430	COG0671	phosphoesterase, PA-phosphatase related
APY30_19435	COG2267	carboxylic ester hydrolase activity
APY30_19440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APY30_19445	COG0138	bifunctional purine biosynthesis protein purh
APY30_19455	COG0151	Belongs to the GarS family
APY30_19465	COG1289	transmembrane transporter activity
APY30_19470	COG2814	Major facilitator Superfamily
APY30_19480	COG2814	Major facilitator Superfamily
APY30_19495	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
APY30_19515	COG0316	Belongs to the HesB IscA family
APY30_19555	COG1051	belongs to the nudix hydrolase family
APY30_19570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
APY30_19575	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APY30_19580	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
APY30_19590	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
APY30_19595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APY30_19605	COG0134	indole-3-glycerol-phosphate synthase activity
APY30_19610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APY30_19635	COG1597	lipid kinase activity
APY30_19640	COG0456	acetyltransferase
APY30_19655	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APY30_19660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APY30_19715	COG2111	Na H antiporter
APY30_19715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APY30_19720	COG1006	Multisubunit Na H antiporter MnhC subunit
APY30_19725	COG0651	ATP synthesis coupled electron transport
APY30_19735	COG2212	antiporter activity
APY30_19740	COG1320	monovalent cation:proton antiporter activity
APY30_19755	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
APY30_19775	COG3104	oligopeptide transport
APY30_19780	COG3483	tryptophan 2,3-dioxygenase activity
APY30_19790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APY30_19805	COG0508	dehydrogenase complex catalyzes the overall conversion of
APY30_19810	COG0513	Belongs to the DEAD box helicase family
APY30_19820	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_19825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APY30_19860	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_19865	COG0702	epimerase
APY30_19890	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APY30_19895	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APY30_19900	COG0297	glycogen (starch) synthase activity
APY30_19905	COG3706	GGDEF domain
APY30_19905	COG0745	RESPONSE REGULATOR receiver
APY30_19910	COG2354	Protein conserved in bacteria
APY30_19915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APY30_19920	COG1368	sulfuric ester hydrolase activity
APY30_19925	COG1511	domain protein
APY30_19925	COG3264	Mechanosensitive ion channel
APY30_20000	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APY30_20070	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
APY30_20075	COG1040	competence protein
APY30_20080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APY30_20085	COG0156	8-amino-7-oxononanoate synthase activity
APY30_20095	COG2267	carboxylic ester hydrolase activity
APY30_20135	COG0445	tRNA wobble uridine modification
APY30_20155	COG1414	Transcriptional regulator
APY30_20165	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APY30_20170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APY30_20180	COG3485	protocatechuate 3,4-dioxygenase
APY30_20195	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
APY30_20200	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
APY30_20225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APY30_20230	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APY30_20285	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APY30_20305	COG0129	dihydroxy-acid dehydratase activity
APY30_20320	COG2801	Transposase and inactivated derivatives
APY30_20360	COG1733	regulation of RNA biosynthetic process
APY30_20365	COG0702	epimerase
APY30_20405	COG0583	DNA-binding transcription factor activity
APY30_20410	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APY30_20425	COG1538	Outer membrane efflux protein
APY30_20435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APY30_20440	COG2205	protein histidine kinase activity
APY30_20445	COG0745	RESPONSE REGULATOR receiver
APY30_20465	COG1902	pentaerythritol trinitrate reductase activity
APY30_20470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APY30_20485	COG2814	Major facilitator Superfamily
APY30_20495	COG2963	transposase activity
APY30_20500	COG2801	Transposase and inactivated derivatives
APY30_20515	COG0084	hydrolase, TatD family'
APY30_20535	COG2252	PERMEase
APY30_20545	COG1957	nucleoside hydrolase
APY30_20580	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
APY30_20600	COG2072	flavoprotein involved in K transport
APY30_20605	COG2351	hydroxyisourate hydrolase activity
APY30_20610	COG4807	Protein conserved in bacteria
APY30_20615	COG1643	Atp-dependent helicase
APY30_20630	COG1187	pseudouridine synthase activity
APY30_20645	COG2130	NADP-dependent
APY30_20675	COG1764	response to oxidative stress
APY30_20680	COG1846	Transcriptional regulator
APY30_20685	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
APY30_20695	COG0697	spore germination
APY30_20765	COG3505	Type IV secretory pathway VirD4
APY30_20805	COG1002	Type II restriction enzyme, methylase subunits
APY30_20910	COG1960	acyl-CoA dehydrogenase activity
APY30_20915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
APY30_20945	COG3706	GGDEF domain
APY30_20950	COG2224	Isocitrate lyase
APY30_20955	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
APY30_20965	COG0475	glutathione-regulated potassium exporter activity
APY30_20995	COG0339	signal peptide processing
APY30_21000	COG1446	asparaginase
APY30_21020	COG0564	pseudouridine synthase activity
APY30_21030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APY30_21040	COG1181	Belongs to the D-alanine--D-alanine ligase family
APY30_21055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APY30_21060	COG0318	PFAM AMP-dependent synthetase and ligase
APY30_21070	COG0596	Alpha beta hydrolase
APY30_21080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APY30_21095	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APY30_21120	COG2205	protein histidine kinase activity
APY30_21125	COG0028	Belongs to the TPP enzyme family
APY30_21135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APY30_21140	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
APY30_21145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APY30_21180	COG0183	Belongs to the thiolase family
APY30_21195	COG2032	superoxide dismutase activity
APY30_21200	COG2032	superoxide dismutase activity
APY30_21205	COG2204	response regulator
APY30_21210	COG3852	Histidine kinase
APY30_21215	COG0004	ammonium transporteR
APY30_21220	COG0347	Belongs to the P(II) protein family
APY30_21225	COG0174	glutamine synthetase
APY30_21230	COG1968	undecaprenyl-diphosphatase activity
APY30_21240	COG1881	PFAM PEBP family protein
APY30_21270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APY30_21280	COG2062	phosphohistidine phosphatase, SixA
APY30_21285	COG0489	protein tyrosine kinase activity
APY30_21310	COG1396	sequence-specific DNA binding
APY30_21330	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APY30_21345	COG1125	glycine betaine transport
APY30_21360	COG1119	ATPase activity
APY30_21370	COG1752	Esterase of the alpha-beta hydrolase superfamily
APY30_21380	COG1522	sequence-specific DNA binding
APY30_21385	COG3186	Phenylalanine-4-hydroxylase
APY30_21400	COG2755	lipolytic protein G-D-S-L family
APY30_21410	COG1028	Short-chain dehydrogenase reductase Sdr
APY30_21415	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
APY30_21420	COG1609	Transcriptional regulator
APY30_21425	COG3507	Belongs to the glycosyl hydrolase 43 family
APY30_21440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APY30_21450	COG0657	acetylesterase activity
APY30_21450	COG2755	lipolytic protein G-D-S-L family
APY30_21480	COG2911	Protein conserved in bacteria
APY30_21485	COG0729	surface antigen
APY30_21490	COG4771	TonB-dependent receptor
APY30_21495	COG0457	Tetratricopeptide repeat
APY30_21505	COG0752	glycyl-tRNA synthetase alpha subunit
APY30_21510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APY30_21520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APY30_21520	COG0519	Catalyzes the synthesis of GMP from XMP
APY30_21530	COG0805	protein transport
APY30_21535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APY30_21540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APY30_21550	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APY30_21570	COG2974	May be involved in recombination
APY30_21575	COG0037	tRNA processing
APY30_21580	COG2115	Belongs to the xylose isomerase family
APY30_21590	COG3661	Belongs to the glycosyl hydrolase 67 family
APY30_21600	COG4948	Mandelate Racemase Muconate Lactonizing
APY30_21610	COG1472	Belongs to the glycosyl hydrolase 3 family
APY30_21615	COG0246	Mannitol dehydrogenase
APY30_21655	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APY30_21680	COG3386	PFAM SMP-30 Gluconolaconase
APY30_21690	COG3250	beta-galactosidase activity
APY30_21695	COG1904	glucuronate isomerase
APY30_21710	COG3693	PFAM glycoside hydrolase, family 10
APY30_21725	COG2211	Major facilitator Superfamily
APY30_21755	COG2963	transposase activity
APY30_21760	COG2801	Transposase and inactivated derivatives
APY30_21790	COG2937	Belongs to the GPAT DAPAT family
APY30_21825	COG0284	orotidine-5'-phosphate decarboxylase activity
APY30_21830	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
APY30_21835	COG3132	Protein of unknown function, DUF480
APY30_21850	COG0210	DNA helicase
APY30_21855	COG1435	thymidine kinase activity
APY30_21865	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
APY30_21875	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APY30_21925	COG0676	glucose-6-phosphate 1-epimerase activity
APY30_21935	COG3012	SEC-C Motif Domain Protein
APY30_21940	COG0730	response to heat
APY30_21960	COG0302	gtp cyclohydrolase
APY30_21975	COG1566	PFAM secretion protein HlyD family protein
APY30_21985	COG1289	transmembrane transporter activity
APY30_21990	COG0477	Major facilitator Superfamily
APY30_21995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APY30_22015	COG4691	Plasmid stability protein
APY30_22030	COG1487	ribonuclease activity
APY30_22070	COG0439	Biotin carboxylase
APY30_22105	COG1074	ATP-dependent DNA helicase activity
APY30_22110	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
APY30_22125	COG1127	ABC transporter
APY30_22130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APY30_22135	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APY30_22150	COG2853	Lipoprotein
APY30_22160	COG0386	Belongs to the glutathione peroxidase family
APY30_22170	COG1322	Protein conserved in bacteria
APY30_22175	COG0604	alcohol dehydrogenase
APY30_22180	COG0583	DNA-binding transcription factor activity
APY30_22190	COG0625	glutathione transferase activity
APY30_22200	COG0531	amino acid
APY30_22205	COG3537	Alpha-1,2-mannosidase
APY30_22215	COG3706	GGDEF domain
APY30_22235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
APY30_22240	COG0861	Integral membrane protein TerC family
APY30_22250	COG0584	glycerophosphoryl diester phosphodiesterase
APY30_22265	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APY30_22270	COG0726	polysaccharide deacetylase
APY30_22280	COG0706	membrane insertase activity
APY30_22285	COG0594	ribonuclease P activity
APY30_22290	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APY30_22300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APY30_22370	COG4456	Virulence-associated protein
APY30_22405	COG2951	lytic endotransglycosylase activity
APY30_22425	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APY30_22585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain