locus-tag	class	description
XCM_0015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XCM_0025	COG0187	DNA topoisomerase II activity
XCM_0035	COG0501	Belongs to the peptidase M48B family
XCM_0065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XCM_0075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCM_0120	COG0793	Belongs to the peptidase S41A family
XCM_0125	COG4942	peptidase
XCM_0135	COG2234	aminopeptidase activity
XCM_0145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCM_0150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCM_0155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCM_0160	COG1064	alcohol dehydrogenase
XCM_0165	COG0493	'glutamate synthase
XCM_0170	COG0067	glutamate synthase
XCM_0170	COG0069	glutamate synthase activity
XCM_0170	COG0070	glutamate synthase
XCM_0190	COG2366	antibiotic biosynthetic process
XCM_0220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
XCM_0235	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XCM_0240	COG0438	transferase activity, transferring glycosyl groups
XCM_0240	COG0297	glycogen (starch) synthase activity
XCM_0260	COG0367	asparagine synthase
XCM_0290	COG1132	(ABC) transporter
XCM_0320	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XCM_0420	COG1111	helicase
XCM_0420	COG1205	dead DEAH box helicase
XCM_0425	COG1272	protein, Hemolysin III
XCM_0440	COG0300	oxidoreductase activity
XCM_0445	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_0460	COG2249	NAD(P)H dehydrogenase (quinone) activity
XCM_0465	COG3237	CsbD-like
XCM_0505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XCM_0510	COG0477	Major facilitator Superfamily
XCM_0550	COG0714	Associated with various cellular activities
XCM_0580	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XCM_0590	COG4772	TonB-dependent receptor
XCM_0600	COG0662	Cupin 2, conserved barrel domain protein
XCM_0605	COG1012	belongs to the aldehyde dehydrogenase family
XCM_0615	COG1012	belongs to the aldehyde dehydrogenase family
XCM_0640	COG1304	FMN binding
XCM_0650	COG4585	Histidine kinase
XCM_0655	COG2197	response regulator
XCM_0680	COG3710	Transcriptional regulator
XCM_0685	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XCM_0735	COG1595	DNA-templated transcription, initiation
XCM_0775	COG0366	Alpha amylase catalytic
XCM_0780	COG0366	Alpha amylase catalytic
XCM_0785	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XCM_0805	COG2755	lipolytic protein G-D-S-L family
XCM_0805	COG0657	acetylesterase activity
XCM_0815	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XCM_0830	COG3507	Belongs to the glycosyl hydrolase 43 family
XCM_0835	COG1609	Transcriptional regulator
XCM_0840	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
XCM_0845	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_0855	COG2755	lipolytic protein G-D-S-L family
XCM_0870	COG3186	Phenylalanine-4-hydroxylase
XCM_0875	COG1522	sequence-specific DNA binding
XCM_0900	COG1752	Esterase of the alpha-beta hydrolase superfamily
XCM_0910	COG1119	ATPase activity
XCM_0925	COG1125	glycine betaine transport
XCM_0940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XCM_0960	COG1396	sequence-specific DNA binding
XCM_0980	COG0489	protein tyrosine kinase activity
XCM_0985	COG2062	phosphohistidine phosphatase, SixA
XCM_0995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCM_10005	COG0489	protein tyrosine kinase activity
XCM_10010	COG0717	Belongs to the dCTP deaminase family
XCM_10050	COG3328	transposase activity
XCM_10055	COG3328	transposase activity
XCM_10070	COG1404	Belongs to the peptidase S8 family
XCM_10075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XCM_10095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XCM_10100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XCM_10115	COG0494	nUDIX hydrolase
XCM_10120	COG0433	COG0433 Predicted ATPase
XCM_10130	COG0688	phosphatidylethanolamine metabolic process
XCM_10140	COG2890	protein-(glutamine-N5) methyltransferase activity
XCM_10145	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XCM_10150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XCM_10155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XCM_10175	COG0101	tRNA pseudouridine synthase activity
XCM_10180	COG0135	phosphoribosylanthranilate isomerase activity
XCM_10190	COG0133	tryptophan synthase activity
XCM_10200	COG0159	tryptophan synthase activity
XCM_10205	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XCM_10210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XCM_10240	COG0300	oxidoreductase activity
XCM_10245	COG0149	triose-phosphate isomerase activity
XCM_10255	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XCM_10260	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XCM_10265	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XCM_10270	COG0649	NAD binding
XCM_10275	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XCM_10280	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XCM_10290	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XCM_10295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XCM_10300	COG0839	Belongs to the complex I subunit 6 family
XCM_10320	COG1007	ATP synthesis coupled electron transport
XCM_10325	COG0779	Required for maturation of 30S ribosomal subunits
XCM_10330	COG0195	Participates in both transcription termination and antitermination
XCM_10335	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XCM_10340	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XCM_10345	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XCM_10350	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XCM_10355	COG1185	polyribonucleotide nucleotidyltransferase activity
XCM_10390	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XCM_1040	COG1968	undecaprenyl-diphosphatase activity
XCM_10400	COG2095	MarC family integral membrane protein
XCM_10410	COG1611	Belongs to the LOG family
XCM_1045	COG0174	glutamine synthetase
XCM_10460	COG3505	Type IV secretory pathway VirD4
XCM_10490	COG2948	multi-organism process
XCM_1050	COG0347	Belongs to the P(II) protein family
XCM_10515	COG0366	Alpha amylase catalytic
XCM_10530	COG0840	transmembrane signaling receptor activity
XCM_10535	COG0840	transmembrane signaling receptor activity
XCM_10540	COG0840	transmembrane signaling receptor activity
XCM_10545	COG0840	transmembrane signaling receptor activity
XCM_1055	COG0004	ammonium transporteR
XCM_10550	COG0840	transmembrane signaling receptor activity
XCM_10555	COG0840	transmembrane signaling receptor activity
XCM_10560	COG0840	transmembrane signaling receptor activity
XCM_10570	COG0840	transmembrane signaling receptor activity
XCM_10575	COG0840	transmembrane signaling receptor activity
XCM_10585	COG0840	transmembrane signaling receptor activity
XCM_1060	COG3852	Histidine kinase
XCM_10600	COG0840	transmembrane signaling receptor activity
XCM_10605	COG0643	Histidine kinase
XCM_10605	COG2198	Histidine kinase
XCM_10610	COG0745	RESPONSE REGULATOR receiver
XCM_10620	COG0835	chemotaxis
XCM_10630	COG1360	Flagellar Motor Protein
XCM_10635	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XCM_1065	COG2204	response regulator
XCM_10660	COG1192	Involved in chromosome partitioning
XCM_1070	COG2032	superoxide dismutase activity
XCM_1075	COG2032	superoxide dismutase activity
XCM_10775	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_10780	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XCM_10785	COG2226	methyltransferase
XCM_10785	COG1073	alpha beta
XCM_1080	COG0346	lactoylglutathione lyase activity
XCM_10835	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XCM_10835	COG0316	Belongs to the HesB IscA family
XCM_10840	COG2154	pterin-4-alpha-carbinolamine dehydratase
XCM_10850	COG0428	transporter
XCM_10855	COG3064	Membrane
XCM_10865	COG1530	ribonuclease E activity
XCM_10875	COG1054	Belongs to the UPF0176 family
XCM_10895	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XCM_1090	COG0183	Belongs to the thiolase family
XCM_10905	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
XCM_10905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XCM_10925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XCM_10935	COG0322	excinuclease ABC activity
XCM_10945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XCM_10950	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XCM_10955	COG1663	tetraacyldisaccharide 4'-kinase activity
XCM_10960	COG1132	(ABC) transporter
XCM_10970	COG0811	peptide transport
XCM_10990	COG1136	(ABC) transporter
XCM_10995	COG4591	ABC-type transport system involved in lipoprotein release permease component
XCM_11005	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XCM_11010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XCM_11025	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XCM_11045	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XCM_11050	COG0837	glucose binding
XCM_11055	COG0363	glucosamine-6-phosphate deaminase activity
XCM_11060	COG0129	dihydroxy-acid dehydratase activity
XCM_11065	COG0800	Aldolase
XCM_11105	COG0784	Response regulator, receiver
XCM_11105	COG2205	protein histidine kinase activity
XCM_11110	COG2183	response to ionizing radiation
XCM_11120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCM_11120	COG0723	plastoquinol--plastocyanin reductase activity
XCM_11135	COG3243	poly(R)-hydroxyalkanoic acid synthase
XCM_11145	COG1183	phosphatidylcholine synthase activity
XCM_11150	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_11165	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XCM_11175	COG0668	transmembrane transport
XCM_11180	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XCM_11195	COG1914	H( )-stimulated, divalent metal cation uptake system
XCM_11210	COG0746	molybdenum cofactor guanylyltransferase activity
XCM_11215	COG0303	'Molybdopterin
XCM_11225	COG0708	Exodeoxyribonuclease III
XCM_1125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XCM_11260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XCM_11265	COG0303	'Molybdopterin
XCM_11270	COG1160	GTP binding
XCM_11275	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XCM_11285	COG1426	Protein conserved in bacteria
XCM_11295	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XCM_1130	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XCM_11310	COG1250	3-hydroxyacyl-CoA dehydrogenase
XCM_11310	COG1024	Enoyl-CoA hydratase
XCM_11315	COG0183	Belongs to the thiolase family
XCM_11320	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XCM_11325	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XCM_11335	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XCM_11345	COG1674	ftsk spoiiie
XCM_1135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XCM_11350	COG0492	ferredoxin-NADP+ reductase activity
XCM_11360	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XCM_11370	COG0542	response to heat
XCM_11385	COG0482	sulfurtransferase activity
XCM_11390	COG2915	High frequency lysogenization protein hflD homolog
XCM_11420	COG5002	protein histidine kinase activity
XCM_11440	COG0784	Response regulator, receiver
XCM_11440	COG0835	chemotaxis
XCM_11450	COG1558	bacterial-type flagellum-dependent cell motility
XCM_11455	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XCM_11465	COG4787	bacterial-type flagellum-dependent cell motility
XCM_11475	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XCM_11480	COG1706	bacterial-type flagellum-dependent cell motility
XCM_11485	COG1705	Flagellar rod assembly protein muramidase FlgJ
XCM_11485	COG3951	Flagellar rod assembly protein muramidase FlgJ
XCM_11495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XCM_11500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XCM_11505	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
XCM_11535	COG2201	protein-glutamate methylesterase activity
XCM_11555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XCM_11565	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_11570	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_11590	COG1677	Flagellar hook-basal body complex protein FliE
XCM_11640	COG3190	flagellar
XCM_11655	COG1684	flagellar biosynthetic protein fliR
XCM_11685	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XCM_11715	COG2198	Histidine kinase
XCM_11715	COG0643	Histidine kinase
XCM_11715	COG0784	Response regulator, receiver
XCM_11755	COG2801	Transposase and inactivated derivatives
XCM_11760	COG2963	transposase activity
XCM_11765	COG2963	transposase activity
XCM_11795	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XCM_11860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XCM_1190	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XCM_11905	COG5001	Diguanylate cyclase
XCM_11920	COG3685	Protein conserved in bacteria
XCM_11940	COG1648	precorrin-2 dehydrogenase activity
XCM_11940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XCM_11945	COG2814	Major facilitator Superfamily
XCM_1195	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XCM_11960	COG1335	isochorismatase
XCM_11975	COG2197	response regulator
XCM_11990	COG0583	DNA-binding transcription factor activity
XCM_11995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XCM_1200	COG4786	Flagellar basal body rod
XCM_12000	COG3002	Belongs to the UPF0753 family
XCM_12040	COG0732	type I restriction modification DNA specificity domain
XCM_12045	COG4804	nuclease activity
XCM_1205	COG4786	Flagellar basal body rod
XCM_12070	COG2948	multi-organism process
XCM_12085	COG3846	protein secretion by the type IV secretion system
XCM_12100	COG3451	type IV secretory pathway VirB4
XCM_12110	COG3838	Conjugal transfer protein Trbc
XCM_12115	COG4962	Type ii secretion system protein e
XCM_12135	COG0583	DNA-binding transcription factor activity
XCM_12145	COG2814	Major facilitator Superfamily
XCM_1215	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XCM_12150	COG0583	DNA-binding transcription factor activity
XCM_12160	COG0583	DNA-binding transcription factor activity
XCM_12165	COG2814	Major facilitator Superfamily
XCM_12175	COG1414	Transcriptional regulator
XCM_12180	COG0477	Major facilitator Superfamily
XCM_12185	COG0583	DNA-binding transcription factor activity
XCM_1220	COG1706	bacterial-type flagellum-dependent cell motility
XCM_12245	COG2003	Belongs to the UPF0758 family
XCM_12265	COG0582	viral genome integration into host DNA
XCM_12305	COG5314	conjugation
XCM_12345	COG0582	viral genome integration into host DNA
XCM_1235	COG1677	Flagellar hook-basal body complex protein FliE
XCM_12360	COG0519	Catalyzes the synthesis of GMP from XMP
XCM_12360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XCM_12370	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XCM_12380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XCM_12380	COG0475	glutathione-regulated potassium exporter activity
XCM_12385	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XCM_12395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XCM_1240	COG1766	The M ring may be actively involved in energy transduction
XCM_12400	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XCM_12410	COG0776	regulation of translation
XCM_12415	COG0539	negative regulation of cytoplasmic translation
XCM_12420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XCM_12440	COG2957	Belongs to the agmatine deiminase family
XCM_12445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XCM_12470	COG0395	ABC-type sugar transport system, permease component
XCM_12475	COG1175	transmembrane transport
XCM_12505	COG2350	Protein conserved in bacteria
XCM_12510	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XCM_12515	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XCM_12520	COG1187	pseudouridine synthase activity
XCM_12540	COG0436	Aminotransferase
XCM_12545	COG4133	protoheme IX ABC transporter activity
XCM_1255	COG1157	protein secretion by the type III secretion system
XCM_12565	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XCM_12570	COG1138	Cytochrome C-type biogenesis protein
XCM_12590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XCM_12595	COG1278	Cold shock
XCM_12600	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XCM_12605	COG4988	ABC transporter
XCM_12615	COG1294	oxidase, subunit
XCM_12635	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XCM_12640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XCM_12650	COG0165	Argininosuccinate lyase
XCM_12655	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XCM_12665	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XCM_12670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XCM_12680	COG0137	argininosuccinate synthase activity
XCM_12685	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XCM_12695	COG0215	cysteine-tRNA ligase activity
XCM_1270	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XCM_12700	COG2166	iron-sulfur cluster assembly
XCM_12720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XCM_12745	COG4302	ethanolamine ammonia-lyase activity
XCM_12775	COG2963	transposase activity
XCM_12810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XCM_12815	COG0402	S-adenosylhomocysteine deaminase activity
XCM_12825	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XCM_12830	COG1509	lysine 2,3-aminomutase activity
XCM_12835	COG5001	Diguanylate cyclase
XCM_12835	COG3300	MHYT domain
XCM_12850	COG0483	inositol monophosphate 1-phosphatase activity
XCM_12855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XCM_12870	COG0488	(ABC) transporter
XCM_12875	COG0513	Belongs to the DEAD box helicase family
XCM_12880	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XCM_12885	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XCM_12895	COG0625	glutathione transferase activity
XCM_12905	COG4681	YaeQ
XCM_12910	COG2081	HI0933 family
XCM_12920	COG0501	Belongs to the peptidase M48B family
XCM_12925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XCM_12930	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_12950	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XCM_12955	COG0860	N-Acetylmuramoyl-L-alanine amidase
XCM_12960	COG0802	atpase or kinase
XCM_12965	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XCM_12965	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XCM_12970	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XCM_12975	COG1570	exodeoxyribonuclease VII activity
XCM_12985	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XCM_13025	COG0835	chemotaxis
XCM_13030	COG0840	transmembrane signaling receptor activity
XCM_13035	COG2094	Belongs to the DNA glycosylase MPG family
XCM_13040	COG1201	RNA secondary structure unwinding
XCM_1305	COG0028	Belongs to the TPP enzyme family
XCM_13055	COG2969	positive regulation of protein catabolic process
XCM_13060	COG0625	glutathione transferase activity
XCM_13065	COG2857	Cytochrome c1
XCM_13070	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XCM_13075	COG0723	plastoquinol--plastocyanin reductase activity
XCM_13080	COG0741	lytic transglycosylase activity
XCM_13095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XCM_1310	COG2205	protein histidine kinase activity
XCM_13100	COG1702	phosphate starvation-inducible protein PhoH
XCM_13120	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XCM_13130	COG4535	Mg2 and Co2 transporter CorC
XCM_13145	COG1012	belongs to the aldehyde dehydrogenase family
XCM_13150	COG1177	transmembrane transport
XCM_13155	COG1176	ABC-type spermidine putrescine transport system, permease component I
XCM_13160	COG3842	ATPase activity
XCM_13180	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XCM_13195	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XCM_13200	COG0174	glutamine synthetase
XCM_13205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCM_13220	COG2703	oxygen carrier activity
XCM_13225	COG0477	Major facilitator Superfamily
XCM_13235	COG0243	molybdopterin cofactor binding
XCM_13240	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XCM_13245	COG2223	nitrite transmembrane transporter activity
XCM_13250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
XCM_13260	COG2733	membrane
XCM_13265	COG2205	protein histidine kinase activity
XCM_13265	COG0784	Response regulator, receiver
XCM_13265	COG5002	protein histidine kinase activity
XCM_13275	COG0477	Major facilitator Superfamily
XCM_13285	COG2902	Dehydrogenase
XCM_13295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCM_13300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCM_13305	COG1609	Transcriptional regulator
XCM_13310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XCM_13310	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XCM_13315	COG1105	Belongs to the carbohydrate kinase PfkB family
XCM_13320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XCM_13320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XCM_1335	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XCM_13370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XCM_13380	COG1862	Preprotein translocase
XCM_13385	COG0343	queuine tRNA-ribosyltransferase activity
XCM_13390	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XCM_13435	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XCM_13440	COG3291	Pkd domain containing protein
XCM_13445	COG0405	Gamma-glutamyltransferase
XCM_13450	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XCM_13465	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XCM_13470	COG0742	ribosomal rna small subunit methyltransferase
XCM_13475	COG0326	Molecular chaperone. Has ATPase activity
XCM_1355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XCM_13555	COG0531	amino acid
XCM_13570	COG0006	proline dipeptidase activity
XCM_13580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XCM_13595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCM_13600	COG3938	Belongs to the proline racemase family
XCM_13610	COG0552	protein localization to endoplasmic reticulum
XCM_13615	COG1194	a g-specific adenine glycosylase
XCM_13620	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XCM_13625	COG4191	Histidine kinase
XCM_13625	COG0784	Response regulator, receiver
XCM_13640	COG0322	excinuclease ABC activity
XCM_1365	COG0596	Alpha beta hydrolase
XCM_13650	COG3040	lipid binding
XCM_13660	COG1960	acyl-CoA dehydrogenase activity
XCM_13670	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XCM_13690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XCM_1370	COG0727	PFAM Uncharacterised protein family (UPF0153)
XCM_13700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XCM_13725	COG0438	transferase activity, transferring glycosyl groups
XCM_13735	COG0438	transferase activity, transferring glycosyl groups
XCM_13740	COG0438	transferase activity, transferring glycosyl groups
XCM_1375	COG0318	PFAM AMP-dependent synthetase and ligase
XCM_13785	COG0072	phenylalanine-tRNA ligase activity
XCM_13785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XCM_13790	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XCM_13805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XCM_13810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XCM_13825	COG1874	Beta-galactosidase
XCM_13825	COG0366	Alpha amylase catalytic
XCM_13830	COG2211	Major facilitator Superfamily
XCM_13840	COG1082	Xylose isomerase domain protein TIM barrel
XCM_1385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XCM_13860	COG0366	Alpha amylase catalytic
XCM_13875	COG0835	chemotaxis
XCM_13890	COG0840	transmembrane signaling receptor activity
XCM_13900	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
XCM_13905	COG2201	protein-glutamate methylesterase activity
XCM_13915	COG2267	carboxylic ester hydrolase activity
XCM_13945	COG0318	PFAM AMP-dependent synthetase and ligase
XCM_1395	COG1181	Belongs to the D-alanine--D-alanine ligase family
XCM_13955	COG0784	Response regulator, receiver
XCM_13955	COG2198	Histidine kinase
XCM_13955	COG2205	protein histidine kinase activity
XCM_13960	COG2205	protein histidine kinase activity
XCM_13960	COG2198	Histidine kinase
XCM_13960	COG0784	Response regulator, receiver
XCM_13970	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XCM_13975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XCM_13980	COG3279	Response regulator of the LytR AlgR family
XCM_13990	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XCM_14000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XCM_14005	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XCM_14015	COG0505	Belongs to the CarA family
XCM_14020	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XCM_14025	COG2258	MOSC domain
XCM_14030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XCM_1405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XCM_14075	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XCM_14095	COG0277	FAD linked oxidase domain protein
XCM_14100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XCM_14110	COG0531	amino acid
XCM_14115	COG0531	amino acid
XCM_14120	COG0235	Class ii aldolase
XCM_14125	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XCM_14130	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XCM_14145	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XCM_14145	COG0140	phosphoribosyl-ATP diphosphatase activity
XCM_1415	COG0564	pseudouridine synthase activity
XCM_14150	COG0107	imidazoleglycerol-phosphate synthase activity
XCM_14155	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XCM_14160	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XCM_14165	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XCM_14165	COG0131	Imidazoleglycerol-phosphate dehydratase
XCM_14170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XCM_14175	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XCM_14180	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XCM_14190	COG0124	histidyl-tRNA synthetase
XCM_14195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XCM_14230	COG2963	transposase activity
XCM_14235	COG2801	Transposase and inactivated derivatives
XCM_14255	COG3210	domain, Protein
XCM_1435	COG1446	asparaginase
XCM_14360	COG0583	DNA-binding transcription factor activity
XCM_14365	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XCM_14370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XCM_14385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XCM_14390	COG1605	Chorismate mutase
XCM_14390	COG0077	Prephenate dehydratase
XCM_14395	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XCM_1440	COG0339	signal peptide processing
XCM_14400	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XCM_14405	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
XCM_14440	COG1228	amidohydrolase
XCM_14445	COG2986	histidine ammonia-lyase
XCM_14455	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XCM_14465	COG4993	Dehydrogenase
XCM_14475	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XCM_14485	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XCM_14490	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XCM_14495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XCM_14505	COG3115	cell septum assembly
XCM_14515	COG0359	binds to the 23S rRNA
XCM_14520	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XCM_14525	COG0360	Binds together with S18 to 16S ribosomal RNA
XCM_14530	COG0316	Belongs to the HesB IscA family
XCM_14535	COG0017	Asparaginyl-tRNA synthetase
XCM_14555	COG2808	Putative FMN-binding domain
XCM_14610	COG0288	reversible hydration of carbon dioxide
XCM_14615	COG0662	Cupin 2, conserved barrel domain protein
XCM_14625	COG3844	kynureninase activity
XCM_14630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XCM_14635	COG2925	Exonuclease
XCM_1465	COG0475	glutathione-regulated potassium exporter activity
XCM_14655	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XCM_14660	COG0116	Belongs to the methyltransferase superfamily
XCM_14660	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XCM_14665	COG0488	(ABC) transporter
XCM_1470	COG0583	DNA-binding transcription factor activity
XCM_14705	COG0494	nUDIX hydrolase
XCM_14715	COG1024	Enoyl-CoA hydratase
XCM_14725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XCM_14735	COG0659	secondary active sulfate transmembrane transporter activity
XCM_1475	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XCM_14760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XCM_14765	COG0573	inorganic phosphate transmembrane transporter activity
XCM_14770	COG0581	inorganic phosphate transmembrane transporter activity
XCM_14775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XCM_14780	COG0704	Plays a role in the regulation of phosphate uptake
XCM_14790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XCM_1480	COG2224	Isocitrate lyase
XCM_14805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XCM_14815	COG0557	exoribonuclease II activity
XCM_14825	COG1960	acyl-CoA dehydrogenase activity
XCM_14830	COG2226	methyltransferase
XCM_14835	COG0646	methionine synthase
XCM_14835	COG1410	methionine synthase
XCM_14850	COG1410	methionine synthase
XCM_14850	COG0646	methionine synthase
XCM_14860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XCM_14885	COG2900	Belongs to the SlyX family
XCM_14900	COG0386	Belongs to the glutathione peroxidase family
XCM_14910	COG1725	Transcriptional regulator
XCM_14915	COG1131	(ABC) transporter
XCM_14945	COG1253	flavin adenine dinucleotide binding
XCM_14965	COG2850	peptidyl-arginine hydroxylation
XCM_15000	COG1132	(ABC) transporter
XCM_15005	COG0583	DNA-binding transcription factor activity
XCM_15035	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XCM_15040	COG0484	heat shock protein binding
XCM_15045	COG0443	Heat shock 70 kDa protein
XCM_15050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XCM_15055	COG1420	regulation of RNA biosynthetic process
XCM_15060	COG0497	DNA recombination
XCM_15070	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XCM_15085	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XCM_1510	COG4770	biotin carboxylase activity
XCM_15115	COG3706	GGDEF domain
XCM_1515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XCM_15155	COG0583	DNA-binding transcription factor activity
XCM_15170	COG0415	Belongs to the DNA photolyase family
XCM_15175	COG0305	Participates in initiation and elongation during chromosome replication
XCM_15185	COG0367	asparagine synthase
XCM_1520	COG1960	acyl-CoA dehydrogenase activity
XCM_15205	COG1960	acyl-CoA dehydrogenase activity
XCM_15220	COG0084	hydrolase, TatD family'
XCM_15225	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XCM_15280	COG0386	Belongs to the glutathione peroxidase family
XCM_15285	COG0339	signal peptide processing
XCM_15340	COG2814	Major facilitator Superfamily
XCM_15345	COG1566	PFAM secretion protein HlyD family protein
XCM_15370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XCM_15380	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XCM_15400	COG4774	siderophore transport
XCM_15410	COG0367	asparagine synthase
XCM_15415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XCM_15420	COG1393	Belongs to the ArsC family
XCM_15430	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XCM_15470	COG0052	Belongs to the universal ribosomal protein uS2 family
XCM_15475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XCM_15485	COG0528	UMP kinase activity
XCM_15490	COG0233	cytoplasmic translational termination
XCM_15495	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XCM_15500	COG0575	Belongs to the CDS family
XCM_15505	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XCM_15510	COG0750	zinc metalloprotease
XCM_15525	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XCM_15530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XCM_15535	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XCM_15540	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XCM_15545	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XCM_15555	COG0825	malonyl-CoA metabolic process
XCM_15570	COG1981	membrane
XCM_15590	COG1695	Transcriptional regulator
XCM_15610	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XCM_15620	COG2040	homocysteine
XCM_15625	COG0833	amino acid
XCM_15630	COG0346	lactoylglutathione lyase activity
XCM_15635	COG1131	(ABC) transporter
XCM_15650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XCM_15650	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XCM_15660	COG2878	Part of a membrane complex involved in electron transport
XCM_15675	COG1595	DNA-templated transcription, initiation
XCM_15700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XCM_15715	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XCM_15720	COG0251	oxidation-reduction process
XCM_15730	COG0392	lysyltransferase activity
XCM_15730	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XCM_1575	COG0523	cobalamin synthesis protein
XCM_15770	COG2814	Major facilitator Superfamily
XCM_15775	COG1902	pentaerythritol trinitrate reductase activity
XCM_15780	COG2824	Alkylphosphonate utilization operon protein PhnA
XCM_15790	COG1047	Peptidyl-prolyl cis-trans
XCM_15795	COG1077	Cell shape determining protein MreB Mrl
XCM_15810	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XCM_15820	COG5487	UPF0391 membrane protein
XCM_15825	COG1451	nucleotide metabolic process
XCM_1585	COG0697	spore germination
XCM_15850	COG0183	Belongs to the thiolase family
XCM_15880	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XCM_15880	COG1793	dna ligase
XCM_15890	COG1793	dna ligase
XCM_15895	COG1201	RNA secondary structure unwinding
XCM_15910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XCM_15915	COG1278	Cold shock
XCM_15920	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XCM_15925	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
XCM_15930	COG1472	Belongs to the glycosyl hydrolase 3 family
XCM_15935	COG3046	protein related to deoxyribodipyrimidine photolyase
XCM_15940	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
XCM_15945	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XCM_1595	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XCM_15950	COG2954	triphosphatase activity
XCM_15955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XCM_15965	COG1381	Involved in DNA repair and RecF pathway recombination
XCM_15970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XCM_15975	COG0571	ribonuclease III activity
XCM_15990	COG0481	GTPase activity
XCM_15995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XCM_1600	COG1846	Transcriptional regulator
XCM_16030	COG1024	Enoyl-CoA hydratase
XCM_16035	COG1960	acyl-CoA dehydrogenase activity
XCM_1605	COG1764	response to oxidative stress
XCM_16055	COG3867	Arabinogalactan endo-beta-1,4-galactanase
XCM_16065	COG3250	beta-galactosidase activity
XCM_16085	COG3209	COG3209 Rhs family protein
XCM_16115	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XCM_16125	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XCM_16145	COG0534	Mate efflux family protein
XCM_16150	COG0335	large ribosomal subunit rRNA binding
XCM_16155	COG0336	Belongs to the RNA methyltransferase TrmD family
XCM_16160	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XCM_16165	COG0228	four-way junction DNA binding
XCM_16170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XCM_16180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XCM_16185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XCM_16210	COG0784	Response regulator, receiver
XCM_16210	COG4191	Histidine kinase
XCM_16215	COG2205	protein histidine kinase activity
XCM_16215	COG3437	response regulator, receiver
XCM_16215	COG3850	Histidine kinase
XCM_16215	COG4999	Histidine kinase
XCM_16220	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XCM_16230	COG2205	protein histidine kinase activity
XCM_16235	COG5507	3-demethylubiquinone-9 3-methyltransferase
XCM_16245	COG4771	TonB-dependent receptor
XCM_16270	COG2172	sigma factor antagonist activity
XCM_16275	COG1366	Belongs to the anti-sigma-factor antagonist family
XCM_16280	COG1366	Belongs to the anti-sigma-factor antagonist family
XCM_16295	COG2207	Transcriptional regulator
XCM_1630	COG2130	NADP-dependent
XCM_16305	COG3152	Membrane
XCM_16320	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XCM_16325	COG1845	cytochrome c oxidase, subunit III
XCM_16330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XCM_16340	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XCM_16345	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XCM_16350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XCM_16355	COG0196	riboflavin kinase activity
XCM_16365	COG0268	Binds directly to 16S ribosomal RNA
XCM_16370	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XCM_16375	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XCM_16380	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XCM_16385	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XCM_16390	COG0824	Thioesterase
XCM_16405	COG1946	Acyl-CoA thioesterase
XCM_16430	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XCM_16440	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
XCM_1645	COG1187	pseudouridine synthase activity
XCM_16465	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XCM_16480	COG2197	response regulator
XCM_16485	COG4585	Histidine kinase
XCM_16495	COG0850	regulation of cytokinetic process
XCM_16500	COG2894	cell division
XCM_16505	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XCM_16515	COG0642	Histidine kinase
XCM_16520	COG0745	RESPONSE REGULATOR receiver
XCM_16535	COG2194	sulfuric ester hydrolase activity
XCM_16550	COG2814	Major facilitator Superfamily
XCM_16555	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XCM_16555	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XCM_16565	COG0656	L-ascorbic acid biosynthetic process
XCM_16570	COG0753	catalase activity
XCM_16600	COG1506	peptidase
XCM_16600	COG0823	Involved in the tonB-independent uptake of proteins
XCM_16615	COG1297	OPT oligopeptide transporter protein
XCM_16630	COG0587	DNA-directed DNA polymerase activity
XCM_16650	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XCM_16695	COG2814	Major facilitator Superfamily
XCM_16730	COG4191	Histidine kinase
XCM_1675	COG1643	Atp-dependent helicase
XCM_16755	COG2022	thiamine diphosphate biosynthetic process
XCM_16760	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XCM_16765	COG0471	metal ion transport
XCM_16765	COG3273	potassium ion transport
XCM_16785	COG1970	mechanosensitive ion channel activity
XCM_1680	COG4807	Protein conserved in bacteria
XCM_16805	COG3250	beta-galactosidase activity
XCM_16810	COG4948	Mandelate Racemase Muconate Lactonizing
XCM_16820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XCM_16830	COG0308	aminopeptidase N
XCM_16835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCM_16845	COG0529	Catalyzes the synthesis of activated sulfate
XCM_16845	COG2895	sulfate adenylyltransferase (ATP) activity
XCM_1685	COG2351	hydroxyisourate hydrolase activity
XCM_16850	COG0175	sulfate reduction
XCM_16855	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XCM_16860	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XCM_16865	COG0175	sulfate reduction
XCM_16885	COG2198	Histidine kinase
XCM_16885	COG2205	protein histidine kinase activity
XCM_16885	COG0784	Response regulator, receiver
XCM_1690	COG2072	flavoprotein involved in K transport
XCM_16905	COG1648	precorrin-2 dehydrogenase activity
XCM_16905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XCM_16920	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
XCM_16925	COG3588	fructose-bisphosphate aldolase
XCM_16930	COG0469	pyruvate kinase activity
XCM_16940	COG0126	phosphoglycerate kinase activity
XCM_16965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XCM_16975	COG3047	cAMP biosynthetic process
XCM_16980	COG3047	cAMP biosynthetic process
XCM_16990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XCM_16990	COG3453	Protein conserved in bacteria
XCM_16995	COG0725	ABC transporter, periplasmic molybdate-binding protein
XCM_17000	COG4149	molybdate abc transporter
XCM_17005	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XCM_17040	COG1376	ErfK ybiS ycfS ynhG family protein
XCM_17045	COG0739	heme binding
XCM_17060	COG4773	Receptor
XCM_17065	COG0596	Alpha beta hydrolase
XCM_17070	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XCM_17075	COG1301	dicarboxylic acid transport
XCM_17085	COG2304	oxidoreductase activity
XCM_1710	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XCM_17105	COG0714	Associated with various cellular activities
XCM_17135	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XCM_17160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XCM_17170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XCM_17180	COG0194	GDP metabolic process
XCM_17185	COG1561	YicC-like family, N-terminal region
XCM_17190	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XCM_17200	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XCM_17205	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XCM_17220	COG0006	proline dipeptidase activity
XCM_17230	COG0006	proline dipeptidase activity
XCM_17235	COG3079	Belongs to the UPF0149 family
XCM_17250	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XCM_17260	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XCM_17270	COG2912	Transglutaminase-like superfamily
XCM_17275	COG1773	rubredoxin
XCM_17280	COG0352	thiamine-phosphate diphosphorylase activity
XCM_17290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XCM_17310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XCM_17340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XCM_17345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XCM_17350	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_17365	COG0671	phosphoesterase, PA-phosphatase related
XCM_17370	COG3781	membrane
XCM_17380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XCM_17385	COG0563	adenylate kinase activity
XCM_17400	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XCM_17410	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XCM_17430	COG3710	Transcriptional regulator
XCM_17435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XCM_17445	COG0840	transmembrane signaling receptor activity
XCM_17450	COG0405	Gamma-glutamyltransferase
XCM_17455	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XCM_17475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XCM_17480	COG0473	3-isopropylmalate dehydrogenase activity
XCM_17485	COG0066	3-isopropylmalate dehydratase activity
XCM_17490	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XCM_17510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XCM_17515	COG1538	Outer membrane efflux protein
XCM_17520	COG1519	Transferase
XCM_17525	COG1560	Kdo2-lipid A biosynthetic process
XCM_1755	COG2252	PERMEase
XCM_17550	COG0281	malic enzyme
XCM_17550	COG0280	phosphate acetyltransferase
XCM_17555	COG1301	dicarboxylic acid transport
XCM_17565	COG2205	protein histidine kinase activity
XCM_17565	COG0784	Response regulator, receiver
XCM_17580	COG0583	DNA-binding transcription factor activity
XCM_17585	COG0667	Aldo Keto reductase
XCM_17605	COG2197	response regulator
XCM_17615	COG0642	Histidine kinase
XCM_17630	COG2851	Citrate transporter
XCM_17640	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_17645	COG1609	Transcriptional regulator
XCM_17650	COG2211	Major facilitator Superfamily
XCM_17675	COG1162	GTPase activity
XCM_17680	COG0436	Aminotransferase
XCM_17695	COG4773	Receptor
XCM_17700	COG0726	polysaccharide deacetylase
XCM_17705	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XCM_17720	COG3964	amidohydrolase
XCM_17725	COG0402	S-adenosylhomocysteine deaminase activity
XCM_1775	COG0084	hydrolase, TatD family'
XCM_17750	COG1307	EDD domain protein, DegV family
XCM_17755	COG0242	peptide deformylase activity
XCM_17775	COG0457	Tetratricopeptide repeat
XCM_17780	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
XCM_17785	COG1215	transferase activity, transferring glycosyl groups
XCM_17795	COG1215	transferase activity, transferring glycosyl groups
XCM_17800	COG1215	transferase activity, transferring glycosyl groups
XCM_17815	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XCM_17870	COG2188	Transcriptional regulator
XCM_17885	COG1450	Type ii and iii secretion system protein
XCM_17900	COG3166	PFAM Fimbrial assembly family protein
XCM_17905	COG3156	type II secretion system protein K
XCM_17910	COG4795	General secretion pathway protein
XCM_17915	COG2165	general secretion pathway protein
XCM_17920	COG4970	Tfp pilus assembly protein FimT
XCM_17925	COG2165	general secretion pathway protein
XCM_17930	COG1459	type II secretion system
XCM_17935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XCM_17940	COG1404	Belongs to the peptidase S8 family
XCM_17945	COG5295	Hep Hag repeat protein
XCM_1795	COG0583	DNA-binding transcription factor activity
XCM_17950	COG1404	Belongs to the peptidase S8 family
XCM_17955	COG5295	Hep Hag repeat protein
XCM_17960	COG0047	phosphoribosylformylglycinamidine synthase activity
XCM_17960	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XCM_17965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XCM_17970	COG4974	Belongs to the 'phage' integrase family
XCM_17985	COG0795	lipopolysaccharide-transporting ATPase activity
XCM_17995	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XCM_1800	COG2814	Major facilitator Superfamily
XCM_18010	COG0525	valine-tRNA ligase activity
XCM_18040	COG0741	lytic transglycosylase activity
XCM_18065	COG1183	phosphatidylcholine synthase activity
XCM_18075	COG0442	prolyl-tRNA aminoacylation
XCM_18095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XCM_18100	COG1127	ABC transporter
XCM_18105	COG3218	ABC-type transport auxiliary lipoprotein component
XCM_18105	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XCM_18135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XCM_18140	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XCM_18140	COG0662	Cupin 2, conserved barrel domain protein
XCM_1815	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XCM_18170	COG2086	electron transfer activity
XCM_18185	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XCM_18185	COG0546	phosphoglycolate phosphatase activity
XCM_18190	COG0277	FAD linked oxidase domain protein
XCM_1820	COG1902	pentaerythritol trinitrate reductase activity
XCM_18200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XCM_18225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XCM_18230	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
XCM_18235	COG0438	transferase activity, transferring glycosyl groups
XCM_18255	COG0438	transferase activity, transferring glycosyl groups
XCM_18260	COG0626	cystathionine gamma-synthase activity
XCM_18295	COG0625	glutathione transferase activity
XCM_18305	COG0513	Belongs to the DEAD box helicase family
XCM_18320	COG4206	TonB-dependent receptor
XCM_18325	COG0720	synthase
XCM_18335	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XCM_18340	COG1956	GAF domain-containing protein
XCM_18350	COG2819	hydrolase of the alpha beta superfamily
XCM_18365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XCM_18370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XCM_18385	COG0339	signal peptide processing
XCM_1840	COG0745	RESPONSE REGULATOR receiver
XCM_18435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XCM_18440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCM_18445	COG4591	ABC-type transport system involved in lipoprotein release permease component
XCM_18445	COG1136	(ABC) transporter
XCM_1845	COG2205	protein histidine kinase activity
XCM_18450	COG0577	efflux transmembrane transporter activity
XCM_18455	COG0577	efflux transmembrane transporter activity
XCM_18455	COG1136	(ABC) transporter
XCM_18470	COG4191	Histidine kinase
XCM_18475	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XCM_18490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XCM_18495	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XCM_1850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCM_18500	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XCM_18505	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XCM_18510	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XCM_18515	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XCM_18525	COG0356	it plays a direct role in the translocation of protons across the membrane
XCM_18545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XCM_18555	COG0508	dehydrogenase complex catalyzes the overall conversion of
XCM_18605	COG2011	ABC-type metal ion transport system permease component
XCM_18610	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XCM_18615	COG0697	spore germination
XCM_18620	COG1666	GTP binding
XCM_18630	COG2198	Histidine kinase
XCM_18630	COG0784	Response regulator, receiver
XCM_18630	COG5002	protein histidine kinase activity
XCM_18655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XCM_18660	COG1187	pseudouridine synthase activity
XCM_18665	COG2813	Specifically methylates the guanine in position
XCM_18685	COG2202	Pas domain
XCM_18685	COG2205	protein histidine kinase activity
XCM_18705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XCM_18710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCM_18765	COG0842	Transport permease protein
XCM_18770	COG1131	(ABC) transporter
XCM_18775	COG0025	NhaP-type Na H and K H
XCM_18780	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XCM_18785	COG1573	uracil-dna glycosylase
XCM_18795	COG3384	dioxygenase
XCM_18805	COG0583	DNA-binding transcription factor activity
XCM_18815	COG0667	Aldo Keto reductase
XCM_18825	COG3590	peptidase
XCM_18845	COG0531	amino acid
XCM_1885	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XCM_18860	COG2972	Histidine kinase
XCM_18875	COG3685	Protein conserved in bacteria
XCM_18880	COG3546	catalase activity
XCM_1890	COG0583	DNA-binding transcription factor activity
XCM_18920	COG2204	response regulator
XCM_18930	COG1271	oxidase subunit
XCM_18935	COG1294	oxidase, subunit
XCM_18950	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_18955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XCM_18975	COG1132	(ABC) transporter
XCM_18990	COG1063	alcohol dehydrogenase
XCM_19005	COG1063	alcohol dehydrogenase
XCM_19080	COG0251	oxidation-reduction process
XCM_19095	COG0840	transmembrane signaling receptor activity
XCM_19110	COG0583	DNA-binding transcription factor activity
XCM_19115	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XCM_19155	COG0024	Methionine aminopeptidase
XCM_19195	COG4695	Portal protein
XCM_1920	COG0702	epimerase
XCM_1925	COG1733	regulation of RNA biosynthetic process
XCM_19290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XCM_19295	COG1490	D-aminoacyl-tRNA deacylase activity
XCM_19300	COG1560	Kdo2-lipid A biosynthetic process
XCM_19345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XCM_19345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XCM_19350	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XCM_19355	COG0242	peptide deformylase activity
XCM_19360	COG1652	LysM domain
XCM_19365	COG0758	DNA mediated transformation
XCM_19385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XCM_19385	COG1754	DNA topoisomerase type I activity
XCM_19390	COG0009	L-threonylcarbamoyladenylate synthase
XCM_19405	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_19415	COG0616	signal peptide processing
XCM_19420	COG0534	Mate efflux family protein
XCM_19440	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XCM_19445	COG0625	glutathione transferase activity
XCM_19460	COG1252	NADH dehydrogenase
XCM_19465	COG2860	membrane
XCM_19470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XCM_19475	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XCM_19480	COG2201	protein-glutamate methylesterase activity
XCM_19485	COG2177	Part of the ABC transporter FtsEX involved in
XCM_19490	COG2884	Cell division ATP-binding protein ftsE
XCM_19500	COG3118	belongs to the thioredoxin family
XCM_19505	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XCM_19510	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XCM_19515	COG0583	DNA-binding transcription factor activity
XCM_19535	COG1652	LysM domain
XCM_19540	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XCM_19540	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XCM_19545	COG1473	amidohydrolase
XCM_19550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCM_19555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCM_19565	COG5383	Protein conserved in bacteria
XCM_19610	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
XCM_19615	COG3023	N-Acetylmuramoyl-L-alanine amidase
XCM_19625	COG4948	Mandelate Racemase Muconate Lactonizing
XCM_19635	COG0531	amino acid
XCM_1965	COG0129	dihydroxy-acid dehydratase activity
XCM_19650	COG4682	membrane
XCM_19655	COG2133	pyrroloquinoline quinone binding
XCM_19665	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XCM_19670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XCM_19680	COG1610	YqeY-like protein
XCM_19685	COG1295	ribonuclease BN
XCM_19690	COG0358	DNA primase activity
XCM_19705	COG0109	protoheme IX farnesyltransferase activity
XCM_19735	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XCM_19750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XCM_19765	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XCM_19770	COG0739	heme binding
XCM_19775	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XCM_19785	COG2223	nitrite transmembrane transporter activity
XCM_19790	COG0708	Exodeoxyribonuclease III
XCM_19795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XCM_1980	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XCM_19805	COG1192	Involved in chromosome partitioning
XCM_19810	COG1475	DNA binding
XCM_19825	COG0463	Glycosyl transferase, family 2
XCM_19845	COG0756	dUTP diphosphatase activity
XCM_19850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XCM_19855	COG2003	Belongs to the UPF0758 family
XCM_19860	COG0018	arginyl-trna synthetase
XCM_19875	COG4221	oxidoreductase activity
XCM_19880	COG2755	lipolytic protein G-D-S-L family
XCM_19880	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XCM_19890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XCM_19895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XCM_19910	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XCM_19915	COG1166	arginine decarboxylase activity
XCM_19940	COG3291	Pkd domain containing protein
XCM_19940	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XCM_19955	COG0606	chelatase, subunit chli
XCM_19970	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XCM_20000	COG1690	Belongs to the RtcB family
XCM_20040	COG1090	epimerase
XCM_20050	COG0642	Histidine kinase
XCM_20070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XCM_20095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XCM_20100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XCM_20115	COG0753	catalase activity
XCM_20130	COG2197	response regulator
XCM_20135	COG4585	Histidine kinase
XCM_20145	COG1136	(ABC) transporter
XCM_20170	COG0697	spore germination
XCM_20185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XCM_20190	COG0180	Tryptophanyl-tRNA synthetase
XCM_20195	COG3237	CsbD-like
XCM_20235	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XCM_20245	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XCM_20250	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XCM_20250	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XCM_20300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XCM_20320	COG1199	ATP-dependent helicase activity
XCM_20335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XCM_2040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XCM_20400	COG2963	transposase activity
XCM_20405	COG2801	Transposase and inactivated derivatives
XCM_20425	COG0625	glutathione transferase activity
XCM_2045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XCM_20460	COG4555	ABC transporter
XCM_20470	COG1476	TRANSCRIPTIONal
XCM_20500	COG4774	siderophore transport
XCM_20515	COG0633	Ferredoxin
XCM_20515	COG0543	2 iron, 2 sulfur cluster binding
XCM_20520	COG1131	(ABC) transporter
XCM_20525	COG0842	Transport permease protein
XCM_20535	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XCM_20565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XCM_20570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XCM_20580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XCM_20580	COG1042	CoA-binding domain protein
XCM_20580	COG0045	succinate-CoA ligase (ADP-forming) activity
XCM_20585	COG2239	Acts as a magnesium transporter
XCM_20600	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XCM_20605	COG3387	PFAM Glycoside hydrolase 15-related
XCM_20620	COG3100	YcgL domain-containing protein
XCM_20625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XCM_20630	COG0463	Glycosyl transferase, family 2
XCM_20660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XCM_20685	COG0823	Involved in the tonB-independent uptake of proteins
XCM_20685	COG1506	peptidase
XCM_20685	COG4946	Tricorn protease homolog
XCM_2070	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XCM_20700	COG0408	coproporphyrinogen oxidase activity
XCM_20740	COG0515	serine threonine protein kinase
XCM_20745	COG0631	protein serine/threonine phosphatase activity
XCM_2075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XCM_2085	COG3485	protocatechuate 3,4-dioxygenase
XCM_2090	COG3485	protocatechuate 3,4-dioxygenase
XCM_20925	COG0210	DNA helicase
XCM_20935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCM_20940	COG0583	DNA-binding transcription factor activity
XCM_20945	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XCM_20955	COG2159	amidohydrolase
XCM_20965	COG2159	amidohydrolase
XCM_20990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCM_2100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XCM_21010	COG0357	Ribosomal RNA small subunit methyltransferase G
XCM_21015	COG3540	Alkaline phosphatase
XCM_21030	COG2091	lysine biosynthetic process via aminoadipic acid
XCM_21045	COG0708	Exodeoxyribonuclease III
XCM_2105	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XCM_21055	COG1940	carbohydrate kinase activity
XCM_21065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XCM_21075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XCM_21080	COG3162	membrane
XCM_21090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XCM_21120	COG3507	Belongs to the glycosyl hydrolase 43 family
XCM_21135	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_21140	COG0179	Fumarylacetoacetate (FAA) hydrolase
XCM_21145	COG4948	Mandelate Racemase Muconate Lactonizing
XCM_2115	COG1414	Transcriptional regulator
XCM_21155	COG3254	rhamnose metabolic process
XCM_21160	COG0738	Major facilitator superfamily
XCM_21165	COG1414	Transcriptional regulator
XCM_21170	COG1971	Probably functions as a manganese efflux pump
XCM_21175	COG2205	protein histidine kinase activity
XCM_21185	COG3459	Glycosyltransferase 36 associated
XCM_21200	COG2211	Major facilitator Superfamily
XCM_21205	COG3265	gluconokinase activity
XCM_21210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XCM_21235	COG2911	Protein conserved in bacteria
XCM_21240	COG0729	surface antigen
XCM_21245	COG4771	TonB-dependent receptor
XCM_2125	COG0657	acetylesterase activity
XCM_21250	COG0457	Tetratricopeptide repeat
XCM_21260	COG0752	glycyl-tRNA synthetase alpha subunit
XCM_21265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XCM_21275	COG0519	Catalyzes the synthesis of GMP from XMP
XCM_21275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XCM_21285	COG0805	protein transport
XCM_21290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XCM_21295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XCM_21305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XCM_21320	COG2974	May be involved in recombination
XCM_21325	COG0037	tRNA processing
XCM_21330	COG2115	Belongs to the xylose isomerase family
XCM_21340	COG3661	Belongs to the glycosyl hydrolase 67 family
XCM_2135	COG0445	tRNA wobble uridine modification
XCM_21350	COG4948	Mandelate Racemase Muconate Lactonizing
XCM_21360	COG1472	Belongs to the glycosyl hydrolase 3 family
XCM_21365	COG0246	Mannitol dehydrogenase
XCM_21415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XCM_21445	COG3386	PFAM SMP-30 Gluconolaconase
XCM_2145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
XCM_21455	COG3250	beta-galactosidase activity
XCM_21460	COG1904	glucuronate isomerase
XCM_21465	COG3693	PFAM glycoside hydrolase, family 10
XCM_21475	COG3693	PFAM glycoside hydrolase, family 10
XCM_21490	COG2211	Major facilitator Superfamily
XCM_21525	COG2937	Belongs to the GPAT DAPAT family
XCM_21560	COG0284	orotidine-5'-phosphate decarboxylase activity
XCM_21565	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
XCM_21570	COG3132	Protein of unknown function, DUF480
XCM_21585	COG0210	DNA helicase
XCM_21590	COG1435	thymidine kinase activity
XCM_21600	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XCM_21610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XCM_21620	COG3135	benzoate transporter
XCM_21640	COG0676	glucose-6-phosphate 1-epimerase activity
XCM_21650	COG3012	SEC-C Motif Domain Protein
XCM_21660	COG0730	response to heat
XCM_21685	COG0302	gtp cyclohydrolase
XCM_21700	COG1566	PFAM secretion protein HlyD family protein
XCM_21710	COG1289	transmembrane transporter activity
XCM_21715	COG0477	Major facilitator Superfamily
XCM_21720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCM_2175	COG2267	carboxylic ester hydrolase activity
XCM_21770	COG0564	pseudouridine synthase activity
XCM_21800	COG1309	transcriptional regulator
XCM_21810	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_21815	COG0439	Biotin carboxylase
XCM_2185	COG0156	8-amino-7-oxononanoate synthase activity
XCM_21855	COG1074	ATP-dependent DNA helicase activity
XCM_21860	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XCM_21875	COG1127	ABC transporter
XCM_21880	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XCM_21885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XCM_2190	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XCM_21900	COG2853	Lipoprotein
XCM_21910	COG0386	Belongs to the glutathione peroxidase family
XCM_21915	COG1322	Protein conserved in bacteria
XCM_21920	COG0604	alcohol dehydrogenase
XCM_21935	COG0625	glutathione transferase activity
XCM_21945	COG0531	amino acid
XCM_2195	COG1040	competence protein
XCM_21950	COG3537	Alpha-1,2-mannosidase
XCM_21960	COG3706	GGDEF domain
XCM_21965	COG3835	regulator
XCM_21970	COG1929	Belongs to the glycerate kinase type-1 family
XCM_21975	COG2271	Major facilitator Superfamily
XCM_21990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XCM_21995	COG0861	Integral membrane protein TerC family
XCM_2200	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XCM_22005	COG0584	glycerophosphoryl diester phosphodiesterase
XCM_22020	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XCM_22025	COG0726	polysaccharide deacetylase
XCM_22030	COG0706	membrane insertase activity
XCM_22035	COG0594	ribonuclease P activity
XCM_22045	COG2801	Transposase and inactivated derivatives
XCM_22100	COG3504	Conjugal transfer protein
XCM_22105	COG2948	multi-organism process
XCM_22125	COG1192	Involved in chromosome partitioning
XCM_22135	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XCM_22215	COG1192	Involved in chromosome partitioning
XCM_22220	COG1475	DNA binding
XCM_22270	COG4680	protein conserved in bacteria
XCM_22320	COG4962	Type ii secretion system protein e
XCM_22385	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XCM_22405	COG3012	SEC-C Motif Domain Protein
XCM_22405	COG3318	Belongs to the UPF0149 family
XCM_22415	COG2963	transposase activity
XCM_22420	COG2801	Transposase and inactivated derivatives
XCM_22445	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XCM_22480	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XCM_22485	COG1192	Involved in chromosome partitioning
XCM_22550	COG3704	protein secretion by the type IV secretion system
XCM_22560	COG3504	Conjugal transfer protein
XCM_22565	COG2948	multi-organism process
XCM_2290	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XCM_2365	COG1511	domain protein
XCM_2365	COG3264	Mechanosensitive ion channel
XCM_2370	COG1368	sulfuric ester hydrolase activity
XCM_2375	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XCM_2380	COG2354	Protein conserved in bacteria
XCM_2390	COG0297	glycogen (starch) synthase activity
XCM_2395	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XCM_2400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XCM_2425	COG0702	epimerase
XCM_2430	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_2460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCM_2465	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_2475	COG0513	Belongs to the DEAD box helicase family
XCM_2500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
XCM_2510	COG3483	tryptophan 2,3-dioxygenase activity
XCM_2515	COG3104	oligopeptide transport
XCM_2535	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
XCM_2550	COG1320	monovalent cation:proton antiporter activity
XCM_2555	COG2212	antiporter activity
XCM_2565	COG0651	ATP synthesis coupled electron transport
XCM_2570	COG1006	Multisubunit Na H antiporter MnhC subunit
XCM_2575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XCM_2575	COG2111	Na H antiporter
XCM_2605	COG3179	chitinase
XCM_2625	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XCM_2630	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XCM_2645	COG0456	acetyltransferase
XCM_2650	COG1597	lipid kinase activity
XCM_2675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XCM_2680	COG0134	indole-3-glycerol-phosphate synthase activity
XCM_2690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XCM_2695	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XCM_2705	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XCM_2715	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XCM_2725	COG1051	belongs to the nudix hydrolase family
XCM_2760	COG0316	Belongs to the HesB IscA family
XCM_2780	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XCM_2795	COG2814	Major facilitator Superfamily
XCM_2805	COG2814	Major facilitator Superfamily
XCM_2810	COG1289	transmembrane transporter activity
XCM_2815	COG0151	Belongs to the GarS family
XCM_2825	COG0138	bifunctional purine biosynthesis protein purh
XCM_2830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XCM_2835	COG2267	carboxylic ester hydrolase activity
XCM_2840	COG2453	phosphatase
XCM_2840	COG0671	phosphoesterase, PA-phosphatase related
XCM_2865	COG4589	Belongs to the CDS family
XCM_2870	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XCM_2895	COG2264	protein methyltransferase activity
XCM_2910	COG0439	Biotin carboxylase
XCM_2920	COG0511	ligase activity, forming carbon-carbon bonds
XCM_2925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XCM_2935	COG1324	tolerance protein
XCM_2955	COG0300	oxidoreductase activity
XCM_2960	COG2356	endonuclease I
XCM_2970	COG0459	protein refolding
XCM_2985	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XCM_3000	COG3386	PFAM SMP-30 Gluconolaconase
XCM_3010	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XCM_3015	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XCM_3030	COG0778	Nitroreductase
XCM_3035	COG2353	YceI-like domain
XCM_3060	COG3052	prosthetic group binding
XCM_3085	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XCM_3095	COG1802	Transcriptional regulator
XCM_3175	COG4221	oxidoreductase activity
XCM_3190	COG4221	oxidoreductase activity
XCM_3200	COG0435	Glutathione S-transferase
XCM_3230	COG2409	Drug exporters of the RND superfamily
XCM_3235	COG0823	Involved in the tonB-independent uptake of proteins
XCM_3235	COG1506	peptidase
XCM_3270	COG0697	spore germination
XCM_3285	COG1113	amino acid transport
XCM_3305	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
XCM_3345	COG5001	Diguanylate cyclase
XCM_3350	COG0840	transmembrane signaling receptor activity
XCM_3355	COG5297	Belongs to the glycosyl hydrolase family 6
XCM_3355	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCM_3360	COG0659	secondary active sulfate transmembrane transporter activity
XCM_3375	COG2943	transferase activity, transferring hexosyl groups
XCM_3385	COG3275	phosphorelay sensor kinase activity
XCM_3395	COG0181	hydroxymethylbilane synthase activity
XCM_3425	COG1505	serine-type exopeptidase activity
XCM_3435	COG0436	Aminotransferase
XCM_3450	COG2832	Protein of unknown function (DUF454)
XCM_3460	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XCM_3470	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XCM_3475	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XCM_3480	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XCM_3505	COG2226	methyltransferase
XCM_3510	COG3300	MHYT domain
XCM_3510	COG5001	Diguanylate cyclase
XCM_3515	COG0308	aminopeptidase N
XCM_3540	COG2010	Cytochrome c
XCM_3560	COG3284	Transcriptional regulator
XCM_3565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XCM_3570	COG1077	Cell shape determining protein MreB Mrl
XCM_3575	COG1792	Involved in formation and maintenance of cell shape
XCM_3590	COG0772	Belongs to the SEDS family
XCM_3595	COG5434	Belongs to the glycosyl hydrolase 28 family
XCM_3600	COG2951	lytic endotransglycosylase activity
XCM_3605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XCM_3610	COG1686	Belongs to the peptidase S11 family
XCM_3620	COG2921	Belongs to the UPF0250 family
XCM_3625	COG0321	lipoyl(octanoyl) transferase activity
XCM_3630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XCM_3660	COG1051	belongs to the nudix hydrolase family
XCM_3660	COG1056	cytidyltransferase-related domain
XCM_3690	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XCM_3695	COG0673	inositol 2-dehydrogenase activity
XCM_3700	COG2823	Periplasmic or secreted lipoprotein
XCM_3705	COG4251	negative regulation of phosphorylation
XCM_3710	COG0784	Response regulator, receiver
XCM_3715	COG4191	Histidine kinase
XCM_3720	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XCM_3775	COG1459	type II secretion system
XCM_3825	COG3250	beta-galactosidase activity
XCM_3845	COG2188	Transcriptional regulator
XCM_3855	COG1609	Transcriptional regulator
XCM_3860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XCM_3865	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XCM_3875	COG0617	tRNA 3'-terminal CCA addition
XCM_3880	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XCM_3885	COG1012	belongs to the aldehyde dehydrogenase family
XCM_3890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XCM_3900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XCM_3915	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XCM_3920	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XCM_3935	COG2205	protein histidine kinase activity
XCM_3965	COG3791	Glutathione-dependent formaldehyde-activating
XCM_3985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XCM_3995	COG0697	spore germination
XCM_4005	COG0488	(ABC) transporter
XCM_4015	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XCM_4020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XCM_4030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XCM_4030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XCM_4050	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XCM_4055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XCM_4060	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XCM_4085	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XCM_4090	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XCM_4095	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
XCM_4100	COG2205	protein histidine kinase activity
XCM_4105	COG0745	RESPONSE REGULATOR receiver
XCM_4125	COG0277	FAD linked oxidase domain protein
XCM_4130	COG1988	membrane-bound metal-dependent
XCM_4135	COG0792	nuclease activity
XCM_4170	COG0275	rRNA processing
XCM_4175	COG3116	cell division
XCM_4185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XCM_4190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XCM_4195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XCM_4205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XCM_4210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XCM_4215	COG1181	Belongs to the D-alanine--D-alanine ligase family
XCM_4220	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XCM_4235	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XCM_4245	COG0739	heme binding
XCM_4250	COG0653	protein targeting
XCM_4255	COG0494	nUDIX hydrolase
XCM_4265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XCM_4280	COG0604	alcohol dehydrogenase
XCM_4280	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_4280	COG3321	synthase
XCM_4300	COG0366	Alpha amylase catalytic
XCM_4330	COG2226	methyltransferase
XCM_4335	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XCM_4345	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XCM_4375	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XCM_4385	COG4106	trans-aconitate 2-methyltransferase activity
XCM_4390	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XCM_4405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XCM_4410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XCM_4415	COG0667	Aldo Keto reductase
XCM_4425	COG4771	TonB-dependent receptor
XCM_4445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XCM_4450	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XCM_4460	COG2175	clavaminate synthase activity
XCM_4470	COG4181	ATPase activity
XCM_4485	COG0642	Histidine kinase
XCM_4495	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XCM_4515	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XCM_4520	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XCM_4535	COG3829	transcription factor binding
XCM_4545	COG1116	anion transmembrane transporter activity
XCM_4550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XCM_4560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XCM_4565	COG0431	NADPH-dependent FMN reductase
XCM_4610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XCM_4620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XCM_4625	COG2967	ApaG domain
XCM_4630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XCM_4635	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XCM_4640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XCM_4645	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XCM_4650	COG0123	including yeast histone deacetylase and acetoin utilization protein
XCM_4655	COG2096	Adenosyltransferase
XCM_4665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XCM_4670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XCM_4700	COG3384	dioxygenase
XCM_4705	COG0583	DNA-binding transcription factor activity
XCM_4715	COG1012	belongs to the aldehyde dehydrogenase family
XCM_4720	COG1012	belongs to the aldehyde dehydrogenase family
XCM_4725	COG1024	Enoyl-CoA hydratase
XCM_4745	COG3386	PFAM SMP-30 Gluconolaconase
XCM_4755	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XCM_4770	COG0697	spore germination
XCM_4775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XCM_4800	COG0784	Response regulator, receiver
XCM_4800	COG5002	protein histidine kinase activity
XCM_4800	COG2205	protein histidine kinase activity
XCM_4805	COG2197	response regulator
XCM_4815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XCM_4830	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XCM_4835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XCM_4840	COG0583	DNA-binding transcription factor activity
XCM_4845	COG3634	alkyl hydroperoxide reductase activity
XCM_4855	COG2890	protein-(glutamine-N5) methyltransferase activity
XCM_4875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XCM_4875	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XCM_4905	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XCM_4930	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
XCM_4945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XCM_4950	COG1404	Belongs to the peptidase S8 family
XCM_4955	COG1404	Belongs to the peptidase S8 family
XCM_4960	COG1404	Belongs to the peptidase S8 family
XCM_4965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XCM_5005	COG1295	ribonuclease BN
XCM_5010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XCM_5015	COG1254	Belongs to the acylphosphatase family
XCM_5030	COG0521	Mo-molybdopterin cofactor biosynthetic process
XCM_5040	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XCM_5045	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XCM_5055	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XCM_5060	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XCM_5065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XCM_5070	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XCM_5075	COG0193	aminoacyl-tRNA hydrolase activity
XCM_5080	COG0012	GTP binding
XCM_5085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XCM_5095	COG0250	Participates in transcription elongation, termination and antitermination
XCM_5100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XCM_5105	COG0081	regulation of translation
XCM_5110	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XCM_5115	COG0222	ribosome binding
XCM_5120	COG0085	RNA polymerase activity
XCM_5125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XCM_5130	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XCM_5135	COG0049	tRNA binding
XCM_5140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XCM_5145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XCM_5150	COG0051	transcription antitermination factor activity, RNA binding
XCM_5155	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XCM_5160	COG0088	Forms part of the polypeptide exit tunnel
XCM_5165	COG0089	rRNA binding
XCM_5170	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XCM_5175	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XCM_5185	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XCM_5190	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XCM_5195	COG0255	Belongs to the universal ribosomal protein uL29 family
XCM_5200	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XCM_5210	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XCM_5215	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XCM_5225	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XCM_5230	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XCM_5235	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XCM_5245	COG1841	ribosomal large subunit assembly
XCM_5250	COG0200	Binds to the 23S rRNA
XCM_5255	COG0201	protein transport
XCM_5280	COG0203	ribosomal protein L17
XCM_5285	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XCM_5300	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XCM_5310	COG0154	amidase activity
XCM_5320	COG1217	gtp-binding protein TYPA
XCM_5325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XCM_5330	COG0039	L-malate dehydrogenase activity
XCM_5335	COG0625	glutathione transferase activity
XCM_5355	COG1902	pentaerythritol trinitrate reductase activity
XCM_5355	COG0446	pyridine nucleotide-disulphide oxidoreductase
XCM_5360	COG0604	alcohol dehydrogenase
XCM_5385	COG0156	8-amino-7-oxononanoate synthase activity
XCM_5390	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XCM_5395	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XCM_5400	COG4208	sulfate ABC transporter
XCM_5405	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XCM_5420	COG1063	alcohol dehydrogenase
XCM_5445	COG0406	alpha-ribazole phosphatase activity
XCM_5455	COG0285	dihydrofolate synthase activity
XCM_5475	COG2833	Protein of unknown function (DUF455)
XCM_5480	COG3291	Pkd domain containing protein
XCM_5490	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XCM_5500	COG0671	phosphoesterase, PA-phosphatase related
XCM_5505	COG0438	transferase activity, transferring glycosyl groups
XCM_5515	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XCM_5530	COG4783	chaperone-mediated protein folding
XCM_5545	COG0473	3-isopropylmalate dehydrogenase activity
XCM_5555	COG3852	Histidine kinase
XCM_5560	COG0544	peptidyl-prolyl cis-trans isomerase activity
XCM_5570	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XCM_5585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XCM_5600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XCM_5610	COG0328	RNA-DNA hybrid ribonuclease activity
XCM_5615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XCM_5620	COG0631	protein serine/threonine phosphatase activity
XCM_5630	COG0859	PFAM glycosyl transferase family 9
XCM_5635	COG3642	lipopolysaccharide core region biosynthetic process
XCM_5640	COG1234	tRNA 3'-trailer cleavage
XCM_5645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XCM_5650	COG0315	cyclic pyranopterin monophosphate synthase activity
XCM_5655	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XCM_5660	COG0314	molybdopterin synthase activity
XCM_5670	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XCM_5675	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XCM_5680	COG0537	adenosine 5'-monophosphoramidase activity
XCM_5700	COG0714	Associated with various cellular activities
XCM_5720	COG0424	maF-like protein
XCM_5725	COG1399	metal-binding, possibly nucleic acid-binding protein
XCM_5730	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XCM_5735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XCM_5750	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_5765	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XCM_5770	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XCM_5790	COG3829	transcription factor binding
XCM_5810	COG3609	addiction module antidote protein, CC2985 family
XCM_5835	COG2373	Large extracellular alpha-helical protein
XCM_5840	COG2373	Large extracellular alpha-helical protein
XCM_5855	COG4953	penicillin-binding protein 1C
XCM_5865	COG0678	peroxiredoxin activity
XCM_5890	COG0330	HflC and HflK could
XCM_5895	COG0330	HflC and HflK could
XCM_5905	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XCM_5910	COG0308	aminopeptidase N
XCM_5920	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_5925	COG1309	transcriptional regulator
XCM_5955	COG4644	lycopene metabolic process
XCM_6010	COG2801	Transposase and inactivated derivatives
XCM_6015	COG2963	transposase activity
XCM_6025	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XCM_6105	COG2801	Transposase and inactivated derivatives
XCM_6195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XCM_6215	COG3387	PFAM Glycoside hydrolase 15-related
XCM_6220	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_6225	COG3537	Alpha-1,2-mannosidase
XCM_6235	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_6245	COG0492	ferredoxin-NADP+ reductase activity
XCM_6270	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XCM_6275	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XCM_6280	COG2080	2 iron, 2 sulfur cluster binding
XCM_6310	COG3621	Patatin-like phospholipase
XCM_6360	COG0189	ligase activity
XCM_6370	COG0745	RESPONSE REGULATOR receiver
XCM_6375	COG5002	protein histidine kinase activity
XCM_6390	COG3209	COG3209 Rhs family protein
XCM_6400	COG0237	dephospho-CoA kinase activity
XCM_6405	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XCM_6420	COG4969	Belongs to the N-Me-Phe pilin family
XCM_6435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XCM_6450	COG0045	succinate-CoA ligase (ADP-forming) activity
XCM_6455	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XCM_6465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XCM_6465	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XCM_6475	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XCM_6480	COG0564	pseudouridine synthase activity
XCM_6500	COG0840	transmembrane signaling receptor activity
XCM_6520	COG3387	PFAM Glycoside hydrolase 15-related
XCM_6525	COG1877	trehalose-phosphatase activity
XCM_6575	COG2827	Endonuclease containing a URI domain
XCM_6585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XCM_6590	COG0667	Aldo Keto reductase
XCM_6595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XCM_6600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XCM_6605	COG1116	anion transmembrane transporter activity
XCM_6610	COG0542	response to heat
XCM_6615	COG4206	TonB-dependent receptor
XCM_6635	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XCM_6645	COG1492	cobalamin metabolic process
XCM_6655	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XCM_6680	COG0019	diaminopimelate decarboxylase activity
XCM_6695	COG4264	IucA IucC family
XCM_6705	COG4772	TonB-dependent receptor
XCM_6730	COG2801	Transposase and inactivated derivatives
XCM_6735	COG2963	transposase activity
XCM_6745	COG4651	solute:proton antiporter activity
XCM_6745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XCM_6775	COG0488	(ABC) transporter
XCM_6820	COG0477	Major facilitator Superfamily
XCM_6835	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XCM_6855	COG0217	transcriptional regulatory protein
XCM_6860	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XCM_6865	COG0632	four-way junction helicase activity
XCM_6870	COG3158	transport of potassium into the cell
XCM_6880	COG2255	four-way junction helicase activity
XCM_6885	COG0824	Thioesterase
XCM_6895	COG0848	biopolymer transport protein
XCM_6905	COG0823	Involved in the tonB-independent uptake of proteins
XCM_6910	COG2885	chlorophyll binding
XCM_6920	COG0602	queuosine metabolic process
XCM_6925	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XCM_6930	COG3920	Histidine kinase
XCM_6950	COG0840	transmembrane signaling receptor activity
XCM_6985	COG0514	ATP-dependent DNA helicase (RecQ)
XCM_6995	COG0783	Belongs to the Dps family
XCM_7000	COG1643	Atp-dependent helicase
XCM_7010	COG0837	glucose binding
XCM_7025	COG0535	radical SAM domain protein
XCM_7030	COG0535	radical SAM domain protein
XCM_7035	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
XCM_7040	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
XCM_7045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XCM_7055	COG1215	transferase activity, transferring glycosyl groups
XCM_7060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XCM_7070	COG1199	ATP-dependent helicase activity
XCM_7080	COG1397	ADP-ribosylglycohydrolase
XCM_7090	COG0189	ligase activity
XCM_7105	COG0835	chemotaxis
XCM_7110	COG0840	transmembrane signaling receptor activity
XCM_7115	COG0643	Histidine kinase
XCM_7115	COG0784	Response regulator, receiver
XCM_7115	COG2198	Histidine kinase
XCM_7145	COG1446	asparaginase
XCM_7150	COG3142	Participates in the control of copper homeostasis
XCM_7185	COG3537	Alpha-1,2-mannosidase
XCM_7195	COG1486	melibiose metabolic process
XCM_7205	COG0531	amino acid
XCM_7220	COG1472	Belongs to the glycosyl hydrolase 3 family
XCM_7230	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XCM_7235	COG3858	chitin binding
XCM_7235	COG1388	LysM domain
XCM_7250	COG0837	glucose binding
XCM_7255	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XCM_7265	COG0494	nUDIX hydrolase
XCM_7275	COG3956	TIGRFAM MazG family protein
XCM_7280	COG1742	UPF0060 membrane protein
XCM_7290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XCM_7295	COG0509	glycine decarboxylation via glycine cleavage system
XCM_7320	COG1960	acyl-CoA dehydrogenase activity
XCM_7330	COG1309	transcriptional regulator
XCM_7335	COG4771	TonB-dependent receptor
XCM_7345	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XCM_7350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XCM_7355	COG0463	Glycosyl transferase, family 2
XCM_7360	COG0517	IMP dehydrogenase activity
XCM_7360	COG0516	GMP reductase activity
XCM_7365	COG2982	Protein involved in outer membrane biogenesis
XCM_7370	COG1272	protein, Hemolysin III
XCM_7375	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XCM_7380	COG0739	heme binding
XCM_7385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XCM_7390	COG0626	cystathionine gamma-synthase activity
XCM_7395	COG0460	homoserine dehydrogenase
XCM_7395	COG0527	aspartate kinase activity
XCM_7405	COG1760	l-serine dehydratase
XCM_7425	COG2353	YceI-like domain
XCM_7430	COG2205	protein histidine kinase activity
XCM_7430	COG2198	Histidine kinase
XCM_7430	COG0784	Response regulator, receiver
XCM_7435	COG0784	Response regulator, receiver
XCM_7435	COG2198	Histidine kinase
XCM_7435	COG5002	protein histidine kinase activity
XCM_7450	COG0477	Major facilitator Superfamily
XCM_7465	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XCM_7475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XCM_7480	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XCM_7485	COG0259	pyridoxamine-phosphate oxidase activity
XCM_7495	COG1842	Phage shock protein A
XCM_7520	COG0754	glutathionylspermidine amidase activity
XCM_7530	COG2814	Major facilitator Superfamily
XCM_7565	COG1234	tRNA 3'-trailer cleavage
XCM_7600	COG0531	amino acid
XCM_7605	COG2197	response regulator
XCM_7630	COG1113	amino acid transport
XCM_7655	COG1271	oxidase subunit
XCM_7660	COG1294	oxidase, subunit
XCM_7670	COG2239	Acts as a magnesium transporter
XCM_7675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XCM_7680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XCM_7690	COG1660	Displays ATPase and GTPase activities
XCM_7695	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XCM_7700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XCM_7715	COG1137	ATPase activity
XCM_7720	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XCM_7730	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XCM_7740	COG0271	Belongs to the BolA IbaG family
XCM_7745	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XCM_7765	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XCM_7780	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XCM_7790	COG0628	permease
XCM_7800	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XCM_7805	COG3178	'Phosphotransferase
XCM_7820	COG1555	photosystem II stabilization
XCM_7835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XCM_7840	COG1477	protein flavinylation
XCM_7865	COG3128	pkhd-type hydroxylase
XCM_7870	COG4774	siderophore transport
XCM_7875	COG2146	nitrite reductase [NAD(P)H] activity
XCM_7885	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XCM_7890	COG0719	Fe-S assembly protein
XCM_7895	COG0396	ATPase activity
XCM_7900	COG0719	Fe-S assembly protein
XCM_7905	COG1959	2 iron, 2 sulfur cluster binding
XCM_7915	COG0693	protein deglycase activity
XCM_7985	COG2963	transposase activity
XCM_7990	COG2801	Transposase and inactivated derivatives
XCM_8020	COG0739	heme binding
XCM_8035	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XCM_8060	COG0519	Catalyzes the synthesis of GMP from XMP
XCM_8065	COG1678	Uncharacterized ACR, COG1678
XCM_8070	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XCM_8075	COG0540	Belongs to the ATCase OTCase family
XCM_8080	COG1764	response to oxidative stress
XCM_8090	COG0384	phenazine biosynthesis protein PhzF
XCM_8095	COG0384	phenazine biosynthesis protein PhzF
XCM_8105	COG0527	aspartate kinase activity
XCM_8120	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XCM_8130	COG0142	geranyltranstransferase activity
XCM_8135	COG0629	single-stranded DNA binding
XCM_8140	COG2203	Gaf domain
XCM_8140	COG3706	GGDEF domain
XCM_8140	COG4251	negative regulation of phosphorylation
XCM_8140	COG5001	Diguanylate cyclase
XCM_8145	COG3321	synthase
XCM_8145	COG1028	Short-chain dehydrogenase reductase Sdr
XCM_8145	COG0604	alcohol dehydrogenase
XCM_8150	COG2080	2 iron, 2 sulfur cluster binding
XCM_8155	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XCM_8160	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XCM_8165	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XCM_8170	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
XCM_8215	COG2879	small protein
XCM_8220	COG1966	Carbon starvation protein
XCM_8225	COG1741	Belongs to the pirin family
XCM_8245	COG1741	Belongs to the pirin family
XCM_8255	COG1515	deoxyribonuclease V activity
XCM_8260	COG0588	phosphoglycerate mutase activity
XCM_8270	COG3590	peptidase
XCM_8275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCM_8280	COG2201	protein-glutamate methylesterase activity
XCM_8285	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XCM_8290	COG2199	diguanylate cyclase activity
XCM_8290	COG2200	EAL domain
XCM_8290	COG2202	Pas domain
XCM_8295	COG0835	chemotaxis
XCM_8300	COG0840	transmembrane signaling receptor activity
XCM_8305	COG0643	Histidine kinase
XCM_8305	COG2198	Histidine kinase
XCM_8310	COG2198	Histidine kinase
XCM_8310	COG0643	Histidine kinase
XCM_8320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XCM_8335	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XCM_8340	COG0745	RESPONSE REGULATOR receiver
XCM_8345	COG2205	protein histidine kinase activity
XCM_8355	COG4452	Inner membrane protein CreD
XCM_8380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XCM_8385	COG0735	belongs to the Fur family
XCM_8400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCM_8410	COG1309	transcriptional regulator
XCM_8425	COG2207	Transcriptional regulator
XCM_8435	COG0583	DNA-binding transcription factor activity
XCM_8440	COG2814	Major facilitator Superfamily
XCM_8445	COG0667	Aldo Keto reductase
XCM_8525	COG2951	lytic endotransglycosylase activity
XCM_8530	COG4644	lycopene metabolic process
XCM_8565	COG2369	cell adhesion
XCM_8685	COG5001	Diguanylate cyclase
XCM_8685	COG5002	protein histidine kinase activity
XCM_8690	COG1187	pseudouridine synthase activity
XCM_8710	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XCM_8720	COG0475	glutathione-regulated potassium exporter activity
XCM_8725	COG5000	phosphorelay sensor kinase activity
XCM_8725	COG5002	protein histidine kinase activity
XCM_8730	COG0745	RESPONSE REGULATOR receiver
XCM_8735	COG1538	Outer membrane efflux protein
XCM_8765	COG1132	(ABC) transporter
XCM_8810	COG2155	Conserved Protein
XCM_8845	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
XCM_8855	COG0840	transmembrane signaling receptor activity
XCM_8880	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XCM_8885	COG0784	Response regulator, receiver
XCM_8885	COG4191	Histidine kinase
XCM_8900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XCM_8910	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XCM_8920	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XCM_8990	COG2244	polysaccharide biosynthetic process
XCM_9020	COG2264	protein methyltransferase activity
XCM_9045	COG1136	(ABC) transporter
XCM_9055	COG0477	Major facilitator Superfamily
XCM_9060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XCM_9075	COG1253	flavin adenine dinucleotide binding
XCM_9085	COG0306	phosphate transporter
XCM_9110	COG0504	CTP synthase activity
XCM_9115	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XCM_9125	COG0148	phosphopyruvate hydratase activity
XCM_9130	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XCM_9135	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XCM_9140	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XCM_9145	COG0585	pseudouridine synthase activity
XCM_9150	COG2840	Smr protein MutS2
XCM_9155	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XCM_9160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XCM_9165	COG1238	metal cluster binding
XCM_9180	COG1534	Rna-binding protein
XCM_9185	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XCM_9195	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XCM_9200	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XCM_9210	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XCM_9215	COG1546	Belongs to the CinA family
XCM_9225	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XCM_9230	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XCM_9235	COG2137	regulation of response to DNA damage stimulus
XCM_9240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XCM_9245	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XCM_9255	COG1741	Belongs to the pirin family
XCM_9260	COG0583	DNA-binding transcription factor activity
XCM_9270	COG0351	phosphomethylpyrimidine kinase
XCM_9285	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XCM_9290	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XCM_9305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XCM_9315	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XCM_9320	COG3734	2-keto-3-deoxy-galactonokinase
XCM_9330	COG4948	Mandelate Racemase Muconate Lactonizing
XCM_9335	COG0800	Aldolase
XCM_9375	COG1501	Belongs to the glycosyl hydrolase 31 family
XCM_9385	COG1070	Carbohydrate kinase
XCM_9390	COG2115	Belongs to the xylose isomerase family
XCM_9395	COG0477	Major facilitator Superfamily
XCM_9415	COG0860	N-Acetylmuramoyl-L-alanine amidase
XCM_9420	COG1469	GTP cyclohydrolase I activity
XCM_9440	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XCM_9445	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XCM_9450	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XCM_9455	COG0166	Belongs to the GPI family
XCM_9475	COG1472	Belongs to the glycosyl hydrolase 3 family
XCM_9485	COG5001	Diguanylate cyclase
XCM_9485	COG4251	negative regulation of phosphorylation
XCM_9485	COG3706	GGDEF domain
XCM_9485	COG2203	Gaf domain
XCM_9490	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCM_9495	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XCM_9510	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XCM_9515	COG0671	phosphoesterase, PA-phosphatase related
XCM_9525	COG1794	racemase activity, acting on amino acids and derivatives
XCM_9530	COG0697	spore germination
XCM_9535	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XCM_9540	COG0167	dihydroorotate dehydrogenase activity
XCM_9555	COG1012	belongs to the aldehyde dehydrogenase family
XCM_9705	COG3081	Nucleoid-associated protein
XCM_9745	COG1215	transferase activity, transferring glycosyl groups
XCM_9750	COG1649	PFAM Uncharacterised BCR, COG1649
XCM_9750	COG0726	polysaccharide deacetylase
XCM_9780	COG3118	belongs to the thioredoxin family
XCM_9790	COG0495	leucyl-tRNA aminoacylation
XCM_9805	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XCM_9820	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XCM_9835	COG2968	Membrane
XCM_9840	COG0424	maF-like protein
XCM_9850	COG3164	Protein of unknown function
XCM_9860	COG0312	modulator of DNA gyrase
XCM_9865	COG3028	Belongs to the UPF0307 family
XCM_9870	COG0312	modulator of DNA gyrase
XCM_9880	COG4104	PAAR repeat-containing protein
XCM_9885	COG0142	geranyltranstransferase activity
XCM_9890	COG1722	exodeoxyribonuclease VII activity
XCM_9895	COG0037	tRNA processing
XCM_9900	COG1785	Belongs to the alkaline phosphatase family
XCM_9905	COG1301	dicarboxylic acid transport
XCM_9910	COG1301	dicarboxylic acid transport
XCM_9915	COG4106	trans-aconitate 2-methyltransferase activity
XCM_9925	COG0791	NLP P60 protein
XCM_9930	COG0791	NLP P60 protein
XCM_9935	COG1047	Peptidyl-prolyl cis-trans
XCM_9940	COG2311	Membrane
XCM_9945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCM_9950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XCM_9970	COG3590	peptidase
XCM_9975	COG3590	peptidase