locus-tag	class	description
CAI17_00005	COG0628	permease
CAI17_00015	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CAI17_00020	COG3178	'Phosphotransferase
CAI17_00035	COG1555	photosystem II stabilization
CAI17_00050	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CAI17_00055	COG1477	protein flavinylation
CAI17_00080	COG3128	pkhd-type hydroxylase
CAI17_00085	COG4774	siderophore transport
CAI17_00090	COG2146	nitrite reductase [NAD(P)H] activity
CAI17_00100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CAI17_00105	COG0719	Fe-S assembly protein
CAI17_00110	COG0396	ATPase activity
CAI17_00115	COG0719	Fe-S assembly protein
CAI17_00120	COG1959	2 iron, 2 sulfur cluster binding
CAI17_00130	COG0693	protein deglycase activity
CAI17_00150	COG0739	heme binding
CAI17_00165	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CAI17_00180	COG5297	Belongs to the glycosyl hydrolase family 6
CAI17_00190	COG0519	Catalyzes the synthesis of GMP from XMP
CAI17_00200	COG1678	Uncharacterized ACR, COG1678
CAI17_00205	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CAI17_00210	COG0540	Belongs to the ATCase OTCase family
CAI17_00215	COG1764	response to oxidative stress
CAI17_00230	COG0384	phenazine biosynthesis protein PhzF
CAI17_00235	COG0527	aspartate kinase activity
CAI17_00250	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CAI17_00265	COG0142	geranyltranstransferase activity
CAI17_00270	COG0629	single-stranded DNA binding
CAI17_00275	COG5001	Diguanylate cyclase
CAI17_00275	COG2203	Gaf domain
CAI17_00275	COG4251	negative regulation of phosphorylation
CAI17_00275	COG3706	GGDEF domain
CAI17_00280	COG0604	alcohol dehydrogenase
CAI17_00280	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_00280	COG3321	synthase
CAI17_00285	COG2080	2 iron, 2 sulfur cluster binding
CAI17_00290	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CAI17_00295	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAI17_00300	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CAI17_00350	COG2879	small protein
CAI17_00355	COG1966	Carbon starvation protein
CAI17_00360	COG1741	Belongs to the pirin family
CAI17_00375	COG1741	Belongs to the pirin family
CAI17_00385	COG1515	deoxyribonuclease V activity
CAI17_00390	COG0588	phosphoglycerate mutase activity
CAI17_00425	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CAI17_00430	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CAI17_00445	COG3829	transcription factor binding
CAI17_00455	COG1116	anion transmembrane transporter activity
CAI17_00460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAI17_00470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAI17_00475	COG0431	NADPH-dependent FMN reductase
CAI17_00500	COG0747	negative chemotaxis
CAI17_00520	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CAI17_00525	COG2967	ApaG domain
CAI17_00530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CAI17_00535	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CAI17_00540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAI17_00545	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CAI17_00550	COG0123	including yeast histone deacetylase and acetoin utilization protein
CAI17_00555	COG2096	Adenosyltransferase
CAI17_00570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAI17_00575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAI17_00605	COG3384	dioxygenase
CAI17_00610	COG0583	DNA-binding transcription factor activity
CAI17_00615	COG0318	PFAM AMP-dependent synthetase and ligase
CAI17_00625	COG1024	Enoyl-CoA hydratase
CAI17_00645	COG3386	PFAM SMP-30 Gluconolaconase
CAI17_00660	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CAI17_00680	COG0697	spore germination
CAI17_00690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAI17_00725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAI17_00735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CAI17_00740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAI17_00750	COG0583	DNA-binding transcription factor activity
CAI17_00755	COG3634	alkyl hydroperoxide reductase activity
CAI17_00765	COG2890	protein-(glutamine-N5) methyltransferase activity
CAI17_00785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CAI17_00785	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CAI17_00815	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CAI17_00835	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CAI17_00855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CAI17_00865	COG1404	Belongs to the peptidase S8 family
CAI17_00875	COG1404	Belongs to the peptidase S8 family
CAI17_00880	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CAI17_00905	COG1295	ribonuclease BN
CAI17_00915	COG1254	Belongs to the acylphosphatase family
CAI17_00945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CAI17_00950	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CAI17_00960	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CAI17_00965	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CAI17_00975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CAI17_00980	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CAI17_00985	COG0193	aminoacyl-tRNA hydrolase activity
CAI17_00990	COG0012	GTP binding
CAI17_01010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CAI17_01025	COG0250	Participates in transcription elongation, termination and antitermination
CAI17_01030	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CAI17_01035	COG0081	regulation of translation
CAI17_01040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CAI17_01045	COG0222	ribosome binding
CAI17_01050	COG0085	RNA polymerase activity
CAI17_01055	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CAI17_01060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CAI17_01065	COG0049	tRNA binding
CAI17_01070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CAI17_01075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CAI17_01080	COG0051	transcription antitermination factor activity, RNA binding
CAI17_01085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CAI17_01090	COG0088	Forms part of the polypeptide exit tunnel
CAI17_01095	COG0089	rRNA binding
CAI17_01100	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CAI17_01105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CAI17_01115	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CAI17_01120	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CAI17_01125	COG0255	Belongs to the universal ribosomal protein uL29 family
CAI17_01130	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CAI17_01140	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CAI17_01145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CAI17_01155	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CAI17_01160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CAI17_01165	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CAI17_01175	COG1841	ribosomal large subunit assembly
CAI17_01180	COG0200	Binds to the 23S rRNA
CAI17_01185	COG0201	protein transport
CAI17_01210	COG0203	ribosomal protein L17
CAI17_01215	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CAI17_01235	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CAI17_01245	COG0154	amidase activity
CAI17_01260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CAI17_01265	COG0039	L-malate dehydrogenase activity
CAI17_01275	COG0625	glutathione transferase activity
CAI17_01295	COG1902	pentaerythritol trinitrate reductase activity
CAI17_01295	COG0446	pyridine nucleotide-disulphide oxidoreductase
CAI17_01330	COG0156	8-amino-7-oxononanoate synthase activity
CAI17_01335	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CAI17_01340	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CAI17_01345	COG4208	sulfate ABC transporter
CAI17_01350	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CAI17_01360	COG1063	alcohol dehydrogenase
CAI17_01395	COG0406	alpha-ribazole phosphatase activity
CAI17_01405	COG0285	dihydrofolate synthase activity
CAI17_01425	COG2833	Protein of unknown function (DUF455)
CAI17_01445	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAI17_01450	COG0671	phosphoesterase, PA-phosphatase related
CAI17_01455	COG0438	transferase activity, transferring glycosyl groups
CAI17_01465	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CAI17_01480	COG4783	chaperone-mediated protein folding
CAI17_01495	COG0473	3-isopropylmalate dehydrogenase activity
CAI17_01525	COG3852	Histidine kinase
CAI17_01535	COG0544	peptidyl-prolyl cis-trans isomerase activity
CAI17_01545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CAI17_01570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAI17_01580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAI17_01590	COG0328	RNA-DNA hybrid ribonuclease activity
CAI17_01595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CAI17_01600	COG0631	protein serine/threonine phosphatase activity
CAI17_01615	COG0859	PFAM glycosyl transferase family 9
CAI17_01620	COG3642	lipopolysaccharide core region biosynthetic process
CAI17_01625	COG1234	tRNA 3'-trailer cleavage
CAI17_01630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CAI17_01635	COG0315	cyclic pyranopterin monophosphate synthase activity
CAI17_01640	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CAI17_01645	COG0314	molybdopterin synthase activity
CAI17_01665	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CAI17_01670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CAI17_01675	COG0537	adenosine 5'-monophosphoramidase activity
CAI17_01695	COG0714	Associated with various cellular activities
CAI17_01725	COG0424	maF-like protein
CAI17_01730	COG1399	metal-binding, possibly nucleic acid-binding protein
CAI17_01735	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CAI17_01740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAI17_01755	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_01770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CAI17_01775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CAI17_01800	COG3829	transcription factor binding
CAI17_01820	COG3609	addiction module antidote protein, CC2985 family
CAI17_01855	COG2373	Large extracellular alpha-helical protein
CAI17_01875	COG4953	penicillin-binding protein 1C
CAI17_01885	COG0678	peroxiredoxin activity
CAI17_01905	COG0330	HflC and HflK could
CAI17_01910	COG0330	HflC and HflK could
CAI17_01920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CAI17_01925	COG0308	aminopeptidase N
CAI17_01930	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_01935	COG1309	transcriptional regulator
CAI17_01965	COG0732	type I restriction modification DNA specificity domain
CAI17_01990	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CAI17_02030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CAI17_02040	COG3387	PFAM Glycoside hydrolase 15-related
CAI17_02045	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_02055	COG3537	Alpha-1,2-mannosidase
CAI17_02060	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_02070	COG0492	ferredoxin-NADP+ reductase activity
CAI17_02130	COG1917	Cupin 2, conserved barrel domain protein
CAI17_02130	COG2207	Transcriptional regulator
CAI17_02155	COG0753	catalase activity
CAI17_02160	COG0656	L-ascorbic acid biosynthetic process
CAI17_02170	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CAI17_02170	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CAI17_02175	COG2814	Major facilitator Superfamily
CAI17_02190	COG2194	sulfuric ester hydrolase activity
CAI17_02205	COG0745	RESPONSE REGULATOR receiver
CAI17_02210	COG0642	Histidine kinase
CAI17_02220	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CAI17_02225	COG2894	cell division
CAI17_02230	COG0850	regulation of cytokinetic process
CAI17_02245	COG4585	Histidine kinase
CAI17_02250	COG2197	response regulator
CAI17_02265	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CAI17_02295	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CAI17_02305	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CAI17_02355	COG0824	Thioesterase
CAI17_02360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CAI17_02365	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CAI17_02370	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CAI17_02375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CAI17_02380	COG0268	Binds directly to 16S ribosomal RNA
CAI17_02390	COG0196	riboflavin kinase activity
CAI17_02395	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CAI17_02400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CAI17_02405	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CAI17_02420	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CAI17_02425	COG1845	cytochrome c oxidase, subunit III
CAI17_02430	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CAI17_02445	COG3152	Membrane
CAI17_02455	COG2207	Transcriptional regulator
CAI17_02460	COG0326	Molecular chaperone. Has ATPase activity
CAI17_02470	COG1366	Belongs to the anti-sigma-factor antagonist family
CAI17_02475	COG1366	Belongs to the anti-sigma-factor antagonist family
CAI17_02480	COG2172	sigma factor antagonist activity
CAI17_02505	COG4771	TonB-dependent receptor
CAI17_02515	COG5507	3-demethylubiquinone-9 3-methyltransferase
CAI17_02520	COG2205	protein histidine kinase activity
CAI17_02530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CAI17_02535	COG3437	response regulator, receiver
CAI17_02535	COG3850	Histidine kinase
CAI17_02535	COG2205	protein histidine kinase activity
CAI17_02535	COG4999	Histidine kinase
CAI17_02575	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CAI17_02580	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CAI17_02590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CAI17_02595	COG0228	four-way junction DNA binding
CAI17_02600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CAI17_02605	COG0336	Belongs to the RNA methyltransferase TrmD family
CAI17_02610	COG0335	large ribosomal subunit rRNA binding
CAI17_02615	COG0534	Mate efflux family protein
CAI17_02635	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CAI17_02645	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CAI17_02670	COG0489	protein tyrosine kinase activity
CAI17_02680	COG0717	Belongs to the dCTP deaminase family
CAI17_02885	COG3179	chitinase
CAI17_02930	COG4695	Portal protein
CAI17_02960	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CAI17_02975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CAI17_02980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAI17_03000	COG0494	nUDIX hydrolase
CAI17_03005	COG0433	COG0433 Predicted ATPase
CAI17_03020	COG0688	phosphatidylethanolamine metabolic process
CAI17_03030	COG2890	protein-(glutamine-N5) methyltransferase activity
CAI17_03035	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CAI17_03040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAI17_03045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CAI17_03065	COG0101	tRNA pseudouridine synthase activity
CAI17_03070	COG0135	phosphoribosylanthranilate isomerase activity
CAI17_03090	COG0159	tryptophan synthase activity
CAI17_03095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CAI17_03100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAI17_03130	COG0300	oxidoreductase activity
CAI17_03135	COG0149	triose-phosphate isomerase activity
CAI17_03150	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAI17_03155	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAI17_03160	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAI17_03165	COG0649	NAD binding
CAI17_03170	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CAI17_03175	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CAI17_03185	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CAI17_03190	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAI17_03195	COG0839	Belongs to the complex I subunit 6 family
CAI17_03215	COG1007	ATP synthesis coupled electron transport
CAI17_03225	COG0779	Required for maturation of 30S ribosomal subunits
CAI17_03230	COG0195	Participates in both transcription termination and antitermination
CAI17_03235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CAI17_03240	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CAI17_03245	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CAI17_03250	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CAI17_03255	COG1185	polyribonucleotide nucleotidyltransferase activity
CAI17_03290	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CAI17_03300	COG2095	MarC family integral membrane protein
CAI17_03315	COG1611	Belongs to the LOG family
CAI17_03370	COG0556	nucleotide-excision repair
CAI17_03390	COG3505	Type IV secretory pathway VirD4
CAI17_03410	COG2948	multi-organism process
CAI17_03460	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CAI17_03465	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CAI17_03480	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CAI17_03485	COG0072	phenylalanine-tRNA ligase activity
CAI17_03485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAI17_03535	COG0438	transferase activity, transferring glycosyl groups
CAI17_03540	COG0438	transferase activity, transferring glycosyl groups
CAI17_03550	COG0438	transferase activity, transferring glycosyl groups
CAI17_03575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAI17_03580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAI17_03585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAI17_03605	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CAI17_03615	COG1960	acyl-CoA dehydrogenase activity
CAI17_03630	COG3040	lipid binding
CAI17_03675	COG4191	Histidine kinase
CAI17_03675	COG0784	Response regulator, receiver
CAI17_03680	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CAI17_03685	COG1194	a g-specific adenine glycosylase
CAI17_03695	COG0552	protein localization to endoplasmic reticulum
CAI17_03705	COG3938	Belongs to the proline racemase family
CAI17_03710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAI17_03725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAI17_03735	COG0006	proline dipeptidase activity
CAI17_03750	COG0531	amino acid
CAI17_03895	COG0726	polysaccharide deacetylase
CAI17_03895	COG1649	PFAM Uncharacterised BCR, COG1649
CAI17_03990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAI17_03995	COG0124	histidyl-tRNA synthetase
CAI17_04005	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CAI17_04010	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CAI17_04015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAI17_04020	COG0131	Imidazoleglycerol-phosphate dehydratase
CAI17_04020	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CAI17_04025	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CAI17_04030	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CAI17_04035	COG0107	imidazoleglycerol-phosphate synthase activity
CAI17_04040	COG0140	phosphoribosyl-ATP diphosphatase activity
CAI17_04040	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CAI17_04055	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CAI17_04060	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CAI17_04065	COG0235	Class ii aldolase
CAI17_04070	COG0531	amino acid
CAI17_04075	COG0531	amino acid
CAI17_04085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAI17_04090	COG0277	FAD linked oxidase domain protein
CAI17_04110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CAI17_04160	COG2258	MOSC domain
CAI17_04165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CAI17_04170	COG0505	Belongs to the CarA family
CAI17_04180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CAI17_04185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAI17_04195	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CAI17_04245	COG3279	Response regulator of the LytR AlgR family
CAI17_04255	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CAI17_04265	COG0784	Response regulator, receiver
CAI17_04265	COG2198	Histidine kinase
CAI17_04265	COG2205	protein histidine kinase activity
CAI17_04270	COG1024	Enoyl-CoA hydratase
CAI17_04305	COG0318	PFAM AMP-dependent synthetase and ligase
CAI17_04335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAI17_04345	COG2201	protein-glutamate methylesterase activity
CAI17_04350	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CAI17_04360	COG0840	transmembrane signaling receptor activity
CAI17_04370	COG0835	chemotaxis
CAI17_04385	COG0840	transmembrane signaling receptor activity
CAI17_04390	COG0840	transmembrane signaling receptor activity
CAI17_04395	COG0840	transmembrane signaling receptor activity
CAI17_04400	COG0840	transmembrane signaling receptor activity
CAI17_04405	COG0840	transmembrane signaling receptor activity
CAI17_04415	COG0840	transmembrane signaling receptor activity
CAI17_04420	COG0840	transmembrane signaling receptor activity
CAI17_04430	COG0840	transmembrane signaling receptor activity
CAI17_04435	COG0840	transmembrane signaling receptor activity
CAI17_04450	COG0840	transmembrane signaling receptor activity
CAI17_04465	COG0840	transmembrane signaling receptor activity
CAI17_04470	COG0643	Histidine kinase
CAI17_04470	COG2198	Histidine kinase
CAI17_04475	COG0745	RESPONSE REGULATOR receiver
CAI17_04485	COG0835	chemotaxis
CAI17_04495	COG1360	Flagellar Motor Protein
CAI17_04500	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CAI17_04540	COG0641	radical SAM
CAI17_04550	COG2198	Histidine kinase
CAI17_04550	COG0643	Histidine kinase
CAI17_04550	COG0784	Response regulator, receiver
CAI17_04580	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CAI17_04605	COG3300	MHYT domain
CAI17_04605	COG5001	Diguanylate cyclase
CAI17_04610	COG1684	flagellar biosynthetic protein fliR
CAI17_04625	COG3190	flagellar
CAI17_04675	COG1677	Flagellar hook-basal body complex protein FliE
CAI17_04720	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_04725	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_04770	COG2201	protein-glutamate methylesterase activity
CAI17_04800	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CAI17_04805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CAI17_04810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CAI17_04820	COG1705	Flagellar rod assembly protein muramidase FlgJ
CAI17_04820	COG3951	Flagellar rod assembly protein muramidase FlgJ
CAI17_04825	COG1706	bacterial-type flagellum-dependent cell motility
CAI17_04830	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CAI17_04845	COG4787	bacterial-type flagellum-dependent cell motility
CAI17_04860	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CAI17_04865	COG1558	bacterial-type flagellum-dependent cell motility
CAI17_04875	COG0835	chemotaxis
CAI17_04875	COG0784	Response regulator, receiver
CAI17_04895	COG5002	protein histidine kinase activity
CAI17_04925	COG2915	High frequency lysogenization protein hflD homolog
CAI17_04930	COG0482	sulfurtransferase activity
CAI17_04945	COG0542	response to heat
CAI17_04955	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CAI17_04965	COG0492	ferredoxin-NADP+ reductase activity
CAI17_04970	COG1674	ftsk spoiiie
CAI17_04980	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CAI17_04990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CAI17_04995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CAI17_05005	COG0183	Belongs to the thiolase family
CAI17_05010	COG1024	Enoyl-CoA hydratase
CAI17_05010	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAI17_05025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CAI17_05035	COG1426	Protein conserved in bacteria
CAI17_05045	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAI17_05050	COG1160	GTP binding
CAI17_05055	COG0303	'Molybdopterin
CAI17_05065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CAI17_05105	COG0708	Exodeoxyribonuclease III
CAI17_05120	COG0746	molybdenum cofactor guanylyltransferase activity
CAI17_05130	COG1648	precorrin-2 dehydrogenase activity
CAI17_05130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CAI17_05170	COG3685	Protein conserved in bacteria
CAI17_05200	COG4566	intracellular signal transduction
CAI17_05220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI17_05250	COG0477	Major facilitator Superfamily
CAI17_05260	COG5002	protein histidine kinase activity
CAI17_05260	COG0784	Response regulator, receiver
CAI17_05260	COG2205	protein histidine kinase activity
CAI17_05265	COG2733	membrane
CAI17_05290	COG2223	nitrite transmembrane transporter activity
CAI17_05295	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CAI17_05300	COG0243	molybdopterin cofactor binding
CAI17_05310	COG0477	Major facilitator Superfamily
CAI17_05315	COG2703	oxygen carrier activity
CAI17_05325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAI17_05330	COG0174	glutamine synthetase
CAI17_05335	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CAI17_05350	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CAI17_05370	COG3842	ATPase activity
CAI17_05375	COG1176	ABC-type spermidine putrescine transport system, permease component I
CAI17_05380	COG1177	transmembrane transport
CAI17_05385	COG1012	belongs to the aldehyde dehydrogenase family
CAI17_05400	COG4535	Mg2 and Co2 transporter CorC
CAI17_05410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CAI17_05420	COG1702	phosphate starvation-inducible protein PhoH
CAI17_05425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CAI17_05440	COG0741	lytic transglycosylase activity
CAI17_05455	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CAI17_05460	COG2857	Cytochrome c1
CAI17_05465	COG0625	glutathione transferase activity
CAI17_05470	COG2969	positive regulation of protein catabolic process
CAI17_05490	COG1201	RNA secondary structure unwinding
CAI17_05495	COG2094	Belongs to the DNA glycosylase MPG family
CAI17_05500	COG0840	transmembrane signaling receptor activity
CAI17_05505	COG0835	chemotaxis
CAI17_05545	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CAI17_05560	COG1570	exodeoxyribonuclease VII activity
CAI17_05565	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CAI17_05570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CAI17_05570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CAI17_05575	COG0802	atpase or kinase
CAI17_05580	COG0860	N-Acetylmuramoyl-L-alanine amidase
CAI17_05585	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CAI17_05615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAI17_05625	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CAI17_05660	COG2081	HI0933 family
CAI17_05665	COG4681	YaeQ
CAI17_05675	COG0625	glutathione transferase activity
CAI17_05685	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CAI17_05690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CAI17_05695	COG0513	Belongs to the DEAD box helicase family
CAI17_05720	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CAI17_05725	COG0483	inositol monophosphate 1-phosphatase activity
CAI17_05740	COG5001	Diguanylate cyclase
CAI17_05740	COG3300	MHYT domain
CAI17_05745	COG1509	lysine 2,3-aminomutase activity
CAI17_05750	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CAI17_05760	COG0402	S-adenosylhomocysteine deaminase activity
CAI17_05765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAI17_05835	COG4302	ethanolamine ammonia-lyase activity
CAI17_05865	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAI17_05870	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CAI17_05885	COG2166	iron-sulfur cluster assembly
CAI17_05890	COG0215	cysteine-tRNA ligase activity
CAI17_05900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CAI17_05905	COG0137	argininosuccinate synthase activity
CAI17_05915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAI17_05920	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CAI17_05930	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CAI17_05935	COG0165	Argininosuccinate lyase
CAI17_05945	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CAI17_05950	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CAI17_05975	COG3344	reverse transcriptase
CAI17_05985	COG1294	oxidase, subunit
CAI17_05995	COG4988	ABC transporter
CAI17_06000	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CAI17_06005	COG1278	Cold shock
CAI17_06010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAI17_06030	COG1138	Cytochrome C-type biogenesis protein
CAI17_06035	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CAI17_06055	COG4133	protoheme IX ABC transporter activity
CAI17_06060	COG0436	Aminotransferase
CAI17_06080	COG1187	pseudouridine synthase activity
CAI17_06085	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CAI17_06090	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CAI17_06095	COG2350	Protein conserved in bacteria
CAI17_06125	COG1175	transmembrane transport
CAI17_06130	COG0395	ABC-type sugar transport system, permease component
CAI17_06155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CAI17_06160	COG2957	Belongs to the agmatine deiminase family
CAI17_06180	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CAI17_06185	COG0539	negative regulation of cytoplasmic translation
CAI17_06190	COG0776	regulation of translation
CAI17_06200	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CAI17_06205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CAI17_06215	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CAI17_06225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CAI17_06225	COG0475	glutathione-regulated potassium exporter activity
CAI17_06235	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CAI17_06245	COG0519	Catalyzes the synthesis of GMP from XMP
CAI17_06245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CAI17_06250	COG3002	Belongs to the UPF0753 family
CAI17_06255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CAI17_06260	COG0583	DNA-binding transcription factor activity
CAI17_06280	COG2197	response regulator
CAI17_06295	COG1335	isochorismatase
CAI17_06320	COG2814	Major facilitator Superfamily
CAI17_06340	COG1914	H( )-stimulated, divalent metal cation uptake system
CAI17_06355	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CAI17_06405	COG3012	SEC-C Motif Domain Protein
CAI17_06405	COG3318	Belongs to the UPF0149 family
CAI17_06470	COG4456	Virulence-associated protein
CAI17_06490	COG0668	transmembrane transport
CAI17_06500	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CAI17_06515	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_06520	COG1183	phosphatidylcholine synthase activity
CAI17_06530	COG3243	poly(R)-hydroxyalkanoic acid synthase
CAI17_06545	COG0723	plastoquinol--plastocyanin reductase activity
CAI17_06545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAI17_06555	COG2183	response to ionizing radiation
CAI17_06560	COG0784	Response regulator, receiver
CAI17_06560	COG2205	protein histidine kinase activity
CAI17_06635	COG0800	Aldolase
CAI17_06640	COG0129	dihydroxy-acid dehydratase activity
CAI17_06645	COG0363	glucosamine-6-phosphate deaminase activity
CAI17_06650	COG0837	glucose binding
CAI17_06655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CAI17_06680	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CAI17_06700	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CAI17_06710	COG4591	ABC-type transport system involved in lipoprotein release permease component
CAI17_06715	COG1136	(ABC) transporter
CAI17_06730	COG0811	peptide transport
CAI17_06740	COG1132	(ABC) transporter
CAI17_06745	COG1663	tetraacyldisaccharide 4'-kinase activity
CAI17_06750	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CAI17_06755	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CAI17_06765	COG0322	excinuclease ABC activity
CAI17_06770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CAI17_06850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAI17_06875	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CAI17_06905	COG1530	ribonuclease E activity
CAI17_06915	COG3064	Membrane
CAI17_06920	COG0428	transporter
CAI17_06930	COG2154	pterin-4-alpha-carbinolamine dehydratase
CAI17_06935	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CAI17_06935	COG0316	Belongs to the HesB IscA family
CAI17_07025	COG2226	methyltransferase
CAI17_07025	COG1073	alpha beta
CAI17_07060	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_07080	COG1238	metal cluster binding
CAI17_07115	COG2902	Dehydrogenase
CAI17_07125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI17_07130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAI17_07140	COG1609	Transcriptional regulator
CAI17_07145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CAI17_07145	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAI17_07150	COG1105	Belongs to the carbohydrate kinase PfkB family
CAI17_07155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAI17_07155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAI17_07195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CAI17_07205	COG1862	Preprotein translocase
CAI17_07210	COG0343	queuine tRNA-ribosyltransferase activity
CAI17_07215	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CAI17_07255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CAI17_07260	COG3291	Pkd domain containing protein
CAI17_07265	COG0405	Gamma-glutamyltransferase
CAI17_07270	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CAI17_07285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CAI17_07290	COG0742	ribosomal rna small subunit methyltransferase
CAI17_07295	COG0326	Molecular chaperone. Has ATPase activity
CAI17_07320	COG1012	belongs to the aldehyde dehydrogenase family
CAI17_07340	COG0167	dihydroorotate dehydrogenase activity
CAI17_07345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CAI17_07375	COG0671	phosphoesterase, PA-phosphatase related
CAI17_07380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CAI17_07395	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CAI17_07400	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CAI17_07410	COG2203	Gaf domain
CAI17_07410	COG3706	GGDEF domain
CAI17_07410	COG4251	negative regulation of phosphorylation
CAI17_07410	COG5001	Diguanylate cyclase
CAI17_07425	COG1472	Belongs to the glycosyl hydrolase 3 family
CAI17_07450	COG0166	Belongs to the GPI family
CAI17_07455	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CAI17_07460	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CAI17_07465	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CAI17_07485	COG1469	GTP cyclohydrolase I activity
CAI17_07490	COG0860	N-Acetylmuramoyl-L-alanine amidase
CAI17_07510	COG0477	Major facilitator Superfamily
CAI17_07515	COG2115	Belongs to the xylose isomerase family
CAI17_07520	COG1070	Carbohydrate kinase
CAI17_07530	COG1501	Belongs to the glycosyl hydrolase 31 family
CAI17_07570	COG0800	Aldolase
CAI17_07575	COG4948	Mandelate Racemase Muconate Lactonizing
CAI17_07585	COG3734	2-keto-3-deoxy-galactonokinase
CAI17_07590	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CAI17_07600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAI17_07615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CAI17_07620	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CAI17_07635	COG0351	phosphomethylpyrimidine kinase
CAI17_07660	COG0583	DNA-binding transcription factor activity
CAI17_07665	COG1741	Belongs to the pirin family
CAI17_07685	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CAI17_07690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CAI17_07695	COG2137	regulation of response to DNA damage stimulus
CAI17_07705	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CAI17_07710	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CAI17_07720	COG1546	Belongs to the CinA family
CAI17_07725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CAI17_07735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CAI17_07740	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CAI17_07750	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CAI17_07755	COG1534	Rna-binding protein
CAI17_07770	COG1238	metal cluster binding
CAI17_07775	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CAI17_07780	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CAI17_07785	COG2840	Smr protein MutS2
CAI17_07790	COG0585	pseudouridine synthase activity
CAI17_07795	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CAI17_07800	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CAI17_07805	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CAI17_07810	COG0148	phosphopyruvate hydratase activity
CAI17_07820	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CAI17_07825	COG0504	CTP synthase activity
CAI17_07850	COG0306	phosphate transporter
CAI17_07865	COG1253	flavin adenine dinucleotide binding
CAI17_07880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAI17_07885	COG0477	Major facilitator Superfamily
CAI17_07890	COG1132	(ABC) transporter
CAI17_07895	COG1136	(ABC) transporter
CAI17_07920	COG2264	protein methyltransferase activity
CAI17_07955	COG2244	polysaccharide biosynthetic process
CAI17_08010	COG1595	DNA-templated transcription, initiation
CAI17_08025	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CAI17_08035	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CAI17_08045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CAI17_08060	COG0784	Response regulator, receiver
CAI17_08060	COG4191	Histidine kinase
CAI17_08065	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CAI17_08100	COG0840	transmembrane signaling receptor activity
CAI17_08125	COG0583	DNA-binding transcription factor activity
CAI17_08130	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CAI17_08135	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CAI17_08150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CAI17_08155	COG1605	Chorismate mutase
CAI17_08155	COG0077	Prephenate dehydratase
CAI17_08160	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CAI17_08165	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CAI17_08170	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CAI17_08210	COG1228	amidohydrolase
CAI17_08215	COG2986	histidine ammonia-lyase
CAI17_08225	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CAI17_08240	COG4993	Dehydrogenase
CAI17_08250	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CAI17_08265	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CAI17_08270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CAI17_08275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAI17_08285	COG3115	cell septum assembly
CAI17_08295	COG0359	binds to the 23S rRNA
CAI17_08300	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CAI17_08305	COG0360	Binds together with S18 to 16S ribosomal RNA
CAI17_08310	COG0316	Belongs to the HesB IscA family
CAI17_08320	COG0017	Asparaginyl-tRNA synthetase
CAI17_08340	COG2808	Putative FMN-binding domain
CAI17_08405	COG0288	reversible hydration of carbon dioxide
CAI17_08410	COG0662	Cupin 2, conserved barrel domain protein
CAI17_08420	COG3844	kynureninase activity
CAI17_08425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAI17_08435	COG2925	Exonuclease
CAI17_08460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CAI17_08465	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CAI17_08465	COG0116	Belongs to the methyltransferase superfamily
CAI17_08510	COG0494	nUDIX hydrolase
CAI17_08520	COG1024	Enoyl-CoA hydratase
CAI17_08530	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CAI17_08535	COG0659	secondary active sulfate transmembrane transporter activity
CAI17_08560	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CAI17_08565	COG0573	inorganic phosphate transmembrane transporter activity
CAI17_08570	COG0581	inorganic phosphate transmembrane transporter activity
CAI17_08575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CAI17_08580	COG0704	Plays a role in the regulation of phosphate uptake
CAI17_08590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CAI17_08595	COG3706	GGDEF domain
CAI17_08600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAI17_08610	COG0557	exoribonuclease II activity
CAI17_08630	COG1960	acyl-CoA dehydrogenase activity
CAI17_08635	COG1960	acyl-CoA dehydrogenase activity
CAI17_08640	COG2226	methyltransferase
CAI17_08645	COG0646	methionine synthase
CAI17_08645	COG1410	methionine synthase
CAI17_08670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAI17_08695	COG2900	Belongs to the SlyX family
CAI17_08710	COG0386	Belongs to the glutathione peroxidase family
CAI17_08720	COG1725	Transcriptional regulator
CAI17_08725	COG1131	(ABC) transporter
CAI17_08755	COG1253	flavin adenine dinucleotide binding
CAI17_08775	COG2850	peptidyl-arginine hydroxylation
CAI17_08810	COG1132	(ABC) transporter
CAI17_08815	COG0583	DNA-binding transcription factor activity
CAI17_08855	COG0484	heat shock protein binding
CAI17_08860	COG0443	Heat shock 70 kDa protein
CAI17_08865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CAI17_08870	COG1420	regulation of RNA biosynthetic process
CAI17_08875	COG0497	DNA recombination
CAI17_08885	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAI17_08900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CAI17_08930	COG3706	GGDEF domain
CAI17_08940	COG3706	GGDEF domain
CAI17_08980	COG0583	DNA-binding transcription factor activity
CAI17_09000	COG0415	Belongs to the DNA photolyase family
CAI17_09005	COG0305	Participates in initiation and elongation during chromosome replication
CAI17_09015	COG0367	asparagine synthase
CAI17_09035	COG1960	acyl-CoA dehydrogenase activity
CAI17_09050	COG0084	hydrolase, TatD family'
CAI17_09055	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CAI17_09115	COG0386	Belongs to the glutathione peroxidase family
CAI17_09125	COG0339	signal peptide processing
CAI17_09155	COG3104	oligopeptide transport
CAI17_09180	COG2814	Major facilitator Superfamily
CAI17_09185	COG1566	PFAM secretion protein HlyD family protein
CAI17_09230	COG4774	siderophore transport
CAI17_09240	COG0367	asparagine synthase
CAI17_09245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAI17_09250	COG1393	Belongs to the ArsC family
CAI17_09260	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CAI17_09300	COG0052	Belongs to the universal ribosomal protein uS2 family
CAI17_09305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CAI17_09315	COG0528	UMP kinase activity
CAI17_09320	COG0233	cytoplasmic translational termination
CAI17_09325	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CAI17_09330	COG0575	Belongs to the CDS family
CAI17_09335	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CAI17_09340	COG0750	zinc metalloprotease
CAI17_09355	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAI17_09360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CAI17_09365	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAI17_09370	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAI17_09375	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CAI17_09385	COG0825	malonyl-CoA metabolic process
CAI17_09420	COG1695	Transcriptional regulator
CAI17_09440	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CAI17_09450	COG2040	homocysteine
CAI17_09455	COG0833	amino acid
CAI17_09460	COG0346	lactoylglutathione lyase activity
CAI17_09465	COG1131	(ABC) transporter
CAI17_09480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAI17_09480	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAI17_09490	COG2878	Part of a membrane complex involved in electron transport
CAI17_09510	COG1595	DNA-templated transcription, initiation
CAI17_09535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAI17_09550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAI17_09555	COG0251	oxidation-reduction process
CAI17_09565	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CAI17_09565	COG0392	lysyltransferase activity
CAI17_09595	COG2814	Major facilitator Superfamily
CAI17_09610	COG2824	Alkylphosphonate utilization operon protein PhnA
CAI17_09620	COG1047	Peptidyl-prolyl cis-trans
CAI17_09640	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CAI17_09650	COG5487	UPF0391 membrane protein
CAI17_09655	COG1451	nucleotide metabolic process
CAI17_09680	COG0183	Belongs to the thiolase family
CAI17_09710	COG1793	dna ligase
CAI17_09710	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CAI17_09720	COG1793	dna ligase
CAI17_09725	COG1201	RNA secondary structure unwinding
CAI17_09740	COG1278	Cold shock
CAI17_09750	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CAI17_09760	COG1472	Belongs to the glycosyl hydrolase 3 family
CAI17_09765	COG3046	protein related to deoxyribodipyrimidine photolyase
CAI17_09770	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CAI17_09775	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CAI17_09780	COG2954	triphosphatase activity
CAI17_09790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CAI17_09800	COG1381	Involved in DNA repair and RecF pathway recombination
CAI17_09805	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CAI17_09810	COG0571	ribonuclease III activity
CAI17_09825	COG0481	GTPase activity
CAI17_09830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAI17_09865	COG1024	Enoyl-CoA hydratase
CAI17_09870	COG1960	acyl-CoA dehydrogenase activity
CAI17_09890	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CAI17_09895	COG3250	beta-galactosidase activity
CAI17_09940	COG3209	COG3209 Rhs family protein
CAI17_09945	COG3209	COG3209 Rhs family protein
CAI17_10000	COG3590	peptidase
CAI17_10010	COG3590	peptidase
CAI17_10035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAI17_10040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAI17_10045	COG2311	Membrane
CAI17_10050	COG1047	Peptidyl-prolyl cis-trans
CAI17_10055	COG0791	NLP P60 protein
CAI17_10060	COG0791	NLP P60 protein
CAI17_10070	COG4106	trans-aconitate 2-methyltransferase activity
CAI17_10075	COG1301	dicarboxylic acid transport
CAI17_10080	COG1785	Belongs to the alkaline phosphatase family
CAI17_10090	COG0037	tRNA processing
CAI17_10095	COG1722	exodeoxyribonuclease VII activity
CAI17_10100	COG0142	geranyltranstransferase activity
CAI17_10110	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CAI17_10130	COG3012	SEC-C Motif Domain Protein
CAI17_10130	COG3318	Belongs to the UPF0149 family
CAI17_10145	COG0312	modulator of DNA gyrase
CAI17_10150	COG3028	Belongs to the UPF0307 family
CAI17_10155	COG0312	modulator of DNA gyrase
CAI17_10165	COG3164	Protein of unknown function
CAI17_10170	COG1530	ribonuclease E activity
CAI17_10175	COG0424	maF-like protein
CAI17_10180	COG2968	Membrane
CAI17_10200	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CAI17_10215	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CAI17_10230	COG0495	leucyl-tRNA aminoacylation
CAI17_10240	COG3118	belongs to the thioredoxin family
CAI17_10280	COG2155	Conserved Protein
CAI17_10325	COG1132	(ABC) transporter
CAI17_10355	COG1538	Outer membrane efflux protein
CAI17_10360	COG0745	RESPONSE REGULATOR receiver
CAI17_10365	COG5002	protein histidine kinase activity
CAI17_10365	COG5000	phosphorelay sensor kinase activity
CAI17_10370	COG0475	glutathione-regulated potassium exporter activity
CAI17_10380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAI17_10405	COG1187	pseudouridine synthase activity
CAI17_10410	COG5001	Diguanylate cyclase
CAI17_10410	COG5002	protein histidine kinase activity
CAI17_10545	COG2814	Major facilitator Superfamily
CAI17_10550	COG0583	DNA-binding transcription factor activity
CAI17_10580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAI17_10595	COG0735	belongs to the Fur family
CAI17_10600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAI17_10625	COG4452	Inner membrane protein CreD
CAI17_10635	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CAI17_10640	COG2205	protein histidine kinase activity
CAI17_10650	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CAI17_10660	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CAI17_10675	COG0643	Histidine kinase
CAI17_10675	COG2198	Histidine kinase
CAI17_10680	COG0840	transmembrane signaling receptor activity
CAI17_10685	COG0835	chemotaxis
CAI17_10690	COG2199	diguanylate cyclase activity
CAI17_10690	COG2202	Pas domain
CAI17_10690	COG2200	EAL domain
CAI17_10695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CAI17_10700	COG2201	protein-glutamate methylesterase activity
CAI17_10705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAI17_10720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CAI17_10740	COG0642	Histidine kinase
CAI17_10755	COG4181	ATPase activity
CAI17_10765	COG2175	clavaminate synthase activity
CAI17_10775	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CAI17_10780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAI17_10800	COG4771	TonB-dependent receptor
CAI17_10810	COG0667	Aldo Keto reductase
CAI17_10820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CAI17_10825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAI17_10835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CAI17_10840	COG4106	trans-aconitate 2-methyltransferase activity
CAI17_10850	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CAI17_10900	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CAI17_10910	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CAI17_10915	COG2226	methyltransferase
CAI17_10950	COG0366	Alpha amylase catalytic
CAI17_10980	COG0604	alcohol dehydrogenase
CAI17_10980	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_10980	COG3321	synthase
CAI17_10995	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CAI17_11005	COG0494	nUDIX hydrolase
CAI17_11010	COG0653	protein targeting
CAI17_11025	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CAI17_11040	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CAI17_11045	COG1181	Belongs to the D-alanine--D-alanine ligase family
CAI17_11050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CAI17_11055	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CAI17_11065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CAI17_11070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CAI17_11075	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CAI17_11085	COG3116	cell division
CAI17_11090	COG0275	rRNA processing
CAI17_11130	COG0792	nuclease activity
CAI17_11135	COG1988	membrane-bound metal-dependent
CAI17_11140	COG0277	FAD linked oxidase domain protein
CAI17_11170	COG0745	RESPONSE REGULATOR receiver
CAI17_11175	COG2205	protein histidine kinase activity
CAI17_11180	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CAI17_11185	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CAI17_11190	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CAI17_11215	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CAI17_11220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CAI17_11225	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CAI17_11245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CAI17_11245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CAI17_11255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CAI17_11260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CAI17_11270	COG0488	(ABC) transporter
CAI17_11280	COG0697	spore germination
CAI17_11290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAI17_11305	COG3791	Glutathione-dependent formaldehyde-activating
CAI17_11330	COG0745	RESPONSE REGULATOR receiver
CAI17_11335	COG2205	protein histidine kinase activity
CAI17_11355	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CAI17_11360	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CAI17_11390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CAI17_11395	COG1012	belongs to the aldehyde dehydrogenase family
CAI17_11400	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CAI17_11405	COG0617	tRNA 3'-terminal CCA addition
CAI17_11415	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CAI17_11420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CAI17_11425	COG1609	Transcriptional regulator
CAI17_11435	COG2188	Transcriptional regulator
CAI17_11450	COG3250	beta-galactosidase activity
CAI17_11480	COG4795	General secretion pathway protein
CAI17_11500	COG1459	type II secretion system
CAI17_11560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CAI17_11565	COG4191	Histidine kinase
CAI17_11570	COG0784	Response regulator, receiver
CAI17_11575	COG4251	negative regulation of phosphorylation
CAI17_11580	COG2823	Periplasmic or secreted lipoprotein
CAI17_11585	COG0673	inositol 2-dehydrogenase activity
CAI17_11590	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CAI17_11625	COG1056	cytidyltransferase-related domain
CAI17_11625	COG1051	belongs to the nudix hydrolase family
CAI17_11635	COG0583	DNA-binding transcription factor activity
CAI17_11650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CAI17_11655	COG0321	lipoyl(octanoyl) transferase activity
CAI17_11660	COG2921	Belongs to the UPF0250 family
CAI17_11670	COG1686	Belongs to the peptidase S11 family
CAI17_11680	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CAI17_11685	COG2951	lytic endotransglycosylase activity
CAI17_11695	COG0772	Belongs to the SEDS family
CAI17_11710	COG1792	Involved in formation and maintenance of cell shape
CAI17_11715	COG1077	Cell shape determining protein MreB Mrl
CAI17_11720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAI17_11725	COG3284	Transcriptional regulator
CAI17_11745	COG2010	Cytochrome c
CAI17_11840	COG5002	protein histidine kinase activity
CAI17_11845	COG0745	RESPONSE REGULATOR receiver
CAI17_11855	COG0189	ligase activity
CAI17_11900	COG2022	thiamine diphosphate biosynthetic process
CAI17_11910	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CAI17_11915	COG0471	metal ion transport
CAI17_11915	COG3273	potassium ion transport
CAI17_11940	COG1970	mechanosensitive ion channel activity
CAI17_11950	COG1609	Transcriptional regulator
CAI17_11960	COG3250	beta-galactosidase activity
CAI17_11965	COG4948	Mandelate Racemase Muconate Lactonizing
CAI17_11980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAI17_12030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAI17_12035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI17_12040	COG0529	Catalyzes the synthesis of activated sulfate
CAI17_12040	COG2895	sulfate adenylyltransferase (ATP) activity
CAI17_12045	COG0175	sulfate reduction
CAI17_12050	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CAI17_12055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CAI17_12060	COG0175	sulfate reduction
CAI17_12080	COG0784	Response regulator, receiver
CAI17_12080	COG2198	Histidine kinase
CAI17_12080	COG2205	protein histidine kinase activity
CAI17_12100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CAI17_12100	COG1648	precorrin-2 dehydrogenase activity
CAI17_12115	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CAI17_12120	COG3588	fructose-bisphosphate aldolase
CAI17_12130	COG0469	pyruvate kinase activity
CAI17_12140	COG0126	phosphoglycerate kinase activity
CAI17_12165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CAI17_12180	COG3047	cAMP biosynthetic process
CAI17_12185	COG3047	cAMP biosynthetic process
CAI17_12195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAI17_12195	COG3453	Protein conserved in bacteria
CAI17_12200	COG0725	ABC transporter, periplasmic molybdate-binding protein
CAI17_12205	COG4149	molybdate abc transporter
CAI17_12210	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CAI17_12245	COG1376	ErfK ybiS ycfS ynhG family protein
CAI17_12255	COG0739	heme binding
CAI17_12265	COG4773	Receptor
CAI17_12270	COG0596	Alpha beta hydrolase
CAI17_12275	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CAI17_12280	COG1301	dicarboxylic acid transport
CAI17_12295	COG2304	oxidoreductase activity
CAI17_12315	COG0714	Associated with various cellular activities
CAI17_12345	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CAI17_12375	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CAI17_12385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CAI17_12390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAI17_12395	COG2390	Transcriptional regulator
CAI17_12410	COG3659	wide pore channel activity
CAI17_12430	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_12435	COG1070	Carbohydrate kinase
CAI17_12445	COG0194	GDP metabolic process
CAI17_12450	COG1561	YicC-like family, N-terminal region
CAI17_12455	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CAI17_12465	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CAI17_12470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CAI17_12485	COG0006	proline dipeptidase activity
CAI17_12495	COG0006	proline dipeptidase activity
CAI17_12500	COG3079	Belongs to the UPF0149 family
CAI17_12520	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CAI17_12530	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CAI17_12540	COG2912	Transglutaminase-like superfamily
CAI17_12545	COG1773	rubredoxin
CAI17_12550	COG0352	thiamine-phosphate diphosphorylase activity
CAI17_12565	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CAI17_12580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAI17_12610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAI17_12615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAI17_12625	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_12635	COG0671	phosphoesterase, PA-phosphatase related
CAI17_12640	COG3781	membrane
CAI17_12650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CAI17_12655	COG0563	adenylate kinase activity
CAI17_12680	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CAI17_12690	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CAI17_12720	COG3710	Transcriptional regulator
CAI17_12725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CAI17_12740	COG0840	transmembrane signaling receptor activity
CAI17_12750	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CAI17_12770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CAI17_12775	COG0473	3-isopropylmalate dehydrogenase activity
CAI17_12780	COG0066	3-isopropylmalate dehydratase activity
CAI17_12785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CAI17_12805	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CAI17_12810	COG1538	Outer membrane efflux protein
CAI17_12815	COG1519	Transferase
CAI17_12820	COG1560	Kdo2-lipid A biosynthetic process
CAI17_12845	COG0280	phosphate acetyltransferase
CAI17_12845	COG0281	malic enzyme
CAI17_12850	COG1301	dicarboxylic acid transport
CAI17_12880	COG0583	DNA-binding transcription factor activity
CAI17_12890	COG0667	Aldo Keto reductase
CAI17_12910	COG2197	response regulator
CAI17_12925	COG0642	Histidine kinase
CAI17_12945	COG2851	Citrate transporter
CAI17_12950	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_12955	COG1609	Transcriptional regulator
CAI17_12985	COG1162	GTPase activity
CAI17_13020	COG0308	aminopeptidase N
CAI17_13025	COG2199	diguanylate cyclase activity
CAI17_13030	COG2226	methyltransferase
CAI17_13055	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CAI17_13060	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CAI17_13065	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CAI17_13075	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CAI17_13085	COG2832	Protein of unknown function (DUF454)
CAI17_13105	COG1505	serine-type exopeptidase activity
CAI17_13145	COG0181	hydroxymethylbilane synthase activity
CAI17_13155	COG3275	phosphorelay sensor kinase activity
CAI17_13165	COG2943	transferase activity, transferring hexosyl groups
CAI17_13185	COG3706	GGDEF domain
CAI17_13195	COG0659	secondary active sulfate transmembrane transporter activity
CAI17_13200	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CAI17_13200	COG5297	Belongs to the glycosyl hydrolase family 6
CAI17_13205	COG0840	transmembrane signaling receptor activity
CAI17_13215	COG5001	Diguanylate cyclase
CAI17_13265	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CAI17_13285	COG1113	amino acid transport
CAI17_13300	COG0697	spore germination
CAI17_13325	COG3706	GGDEF domain
CAI17_13345	COG0823	Involved in the tonB-independent uptake of proteins
CAI17_13345	COG1506	peptidase
CAI17_13355	COG2409	Drug exporters of the RND superfamily
CAI17_13380	COG0435	Glutathione S-transferase
CAI17_13395	COG4221	oxidoreductase activity
CAI17_13410	COG4221	oxidoreductase activity
CAI17_13485	COG1802	Transcriptional regulator
CAI17_13520	COG3052	prosthetic group binding
CAI17_13550	COG2353	YceI-like domain
CAI17_13555	COG0778	Nitroreductase
CAI17_13575	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CAI17_13580	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CAI17_13590	COG3386	PFAM SMP-30 Gluconolaconase
CAI17_13605	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CAI17_13620	COG0459	protein refolding
CAI17_13630	COG2356	endonuclease I
CAI17_13640	COG0300	oxidoreductase activity
CAI17_13670	COG1324	tolerance protein
CAI17_13680	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CAI17_13685	COG0511	ligase activity, forming carbon-carbon bonds
CAI17_13695	COG0439	Biotin carboxylase
CAI17_13715	COG2264	protein methyltransferase activity
CAI17_13740	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CAI17_13745	COG4589	Belongs to the CDS family
CAI17_13770	COG2453	phosphatase
CAI17_13770	COG0671	phosphoesterase, PA-phosphatase related
CAI17_13775	COG2267	carboxylic ester hydrolase activity
CAI17_13780	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CAI17_13785	COG0138	bifunctional purine biosynthesis protein purh
CAI17_13795	COG0151	Belongs to the GarS family
CAI17_13805	COG1289	transmembrane transporter activity
CAI17_13810	COG2814	Major facilitator Superfamily
CAI17_13820	COG2814	Major facilitator Superfamily
CAI17_13840	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CAI17_13860	COG0316	Belongs to the HesB IscA family
CAI17_13900	COG1051	belongs to the nudix hydrolase family
CAI17_13915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CAI17_13925	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CAI17_13935	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CAI17_13940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAI17_13950	COG0134	indole-3-glycerol-phosphate synthase activity
CAI17_13955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CAI17_13980	COG1597	lipid kinase activity
CAI17_13985	COG0456	acetyltransferase
CAI17_14000	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CAI17_14005	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CAI17_14025	COG3179	chitinase
CAI17_14050	COG2111	Na H antiporter
CAI17_14050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CAI17_14055	COG1006	Multisubunit Na H antiporter MnhC subunit
CAI17_14060	COG0651	ATP synthesis coupled electron transport
CAI17_14070	COG2212	antiporter activity
CAI17_14075	COG1320	monovalent cation:proton antiporter activity
CAI17_14095	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CAI17_14120	COG3104	oligopeptide transport
CAI17_14125	COG3483	tryptophan 2,3-dioxygenase activity
CAI17_14140	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CAI17_14160	COG0513	Belongs to the DEAD box helicase family
CAI17_14175	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_14180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAI17_14215	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_14220	COG0702	epimerase
CAI17_14245	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CAI17_14250	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CAI17_14255	COG0297	glycogen (starch) synthase activity
CAI17_14265	COG2354	Protein conserved in bacteria
CAI17_14270	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CAI17_14280	COG1368	sulfuric ester hydrolase activity
CAI17_14285	COG1511	domain protein
CAI17_14285	COG3264	Mechanosensitive ion channel
CAI17_14355	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CAI17_14445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CAI17_14450	COG1040	competence protein
CAI17_14455	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CAI17_14460	COG0156	8-amino-7-oxononanoate synthase activity
CAI17_14470	COG2267	carboxylic ester hydrolase activity
CAI17_14510	COG0445	tRNA wobble uridine modification
CAI17_14530	COG1414	Transcriptional regulator
CAI17_14540	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAI17_14545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAI17_14560	COG3485	protocatechuate 3,4-dioxygenase
CAI17_14570	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CAI17_14575	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CAI17_14605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CAI17_14610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CAI17_14670	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CAI17_14685	COG0129	dihydroxy-acid dehydratase activity
CAI17_14730	COG1733	regulation of RNA biosynthetic process
CAI17_14735	COG0702	epimerase
CAI17_14770	COG0583	DNA-binding transcription factor activity
CAI17_14775	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CAI17_14800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI17_14805	COG2205	protein histidine kinase activity
CAI17_14810	COG0745	RESPONSE REGULATOR receiver
CAI17_14830	COG1902	pentaerythritol trinitrate reductase activity
CAI17_14835	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CAI17_14850	COG2814	Major facilitator Superfamily
CAI17_14855	COG0583	DNA-binding transcription factor activity
CAI17_14875	COG0084	hydrolase, TatD family'
CAI17_14900	COG2252	PERMEase
CAI17_14910	COG1957	nucleoside hydrolase
CAI17_14945	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CAI17_14965	COG2072	flavoprotein involved in K transport
CAI17_14970	COG2351	hydroxyisourate hydrolase activity
CAI17_14975	COG4807	Protein conserved in bacteria
CAI17_14980	COG1643	Atp-dependent helicase
CAI17_14995	COG1187	pseudouridine synthase activity
CAI17_15010	COG2130	NADP-dependent
CAI17_15040	COG1764	response to oxidative stress
CAI17_15045	COG1846	Transcriptional regulator
CAI17_15050	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CAI17_15070	COG0523	cobalamin synthesis protein
CAI17_15125	COG1309	transcriptional regulator
CAI17_15130	COG1960	acyl-CoA dehydrogenase activity
CAI17_15135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CAI17_15140	COG4770	biotin carboxylase activity
CAI17_15175	COG3706	GGDEF domain
CAI17_15180	COG2224	Isocitrate lyase
CAI17_15185	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CAI17_15190	COG0583	DNA-binding transcription factor activity
CAI17_15195	COG0475	glutathione-regulated potassium exporter activity
CAI17_15225	COG0339	signal peptide processing
CAI17_15230	COG1446	asparaginase
CAI17_15250	COG0564	pseudouridine synthase activity
CAI17_15260	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CAI17_15285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAI17_15290	COG0318	PFAM AMP-dependent synthetase and ligase
CAI17_15295	COG0727	PFAM Uncharacterised protein family (UPF0153)
CAI17_15300	COG0596	Alpha beta hydrolase
CAI17_15310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAI17_15325	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CAI17_15350	COG2205	protein histidine kinase activity
CAI17_15355	COG0028	Belongs to the TPP enzyme family
CAI17_15390	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CAI17_15415	COG1157	protein secretion by the type III secretion system
CAI17_15430	COG1766	The M ring may be actively involved in energy transduction
CAI17_15435	COG1677	Flagellar hook-basal body complex protein FliE
CAI17_15450	COG1706	bacterial-type flagellum-dependent cell motility
CAI17_15465	COG4786	Flagellar basal body rod
CAI17_15470	COG4786	Flagellar basal body rod
CAI17_15475	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CAI17_15480	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CAI17_15535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CAI17_15540	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CAI17_15545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CAI17_15580	COG0183	Belongs to the thiolase family
CAI17_15595	COG2032	superoxide dismutase activity
CAI17_15600	COG2032	superoxide dismutase activity
CAI17_15605	COG2204	response regulator
CAI17_15610	COG3852	Histidine kinase
CAI17_15615	COG0004	ammonium transporteR
CAI17_15620	COG0347	Belongs to the P(II) protein family
CAI17_15625	COG0174	glutamine synthetase
CAI17_15635	COG1968	undecaprenyl-diphosphatase activity
CAI17_15680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAI17_15690	COG2062	phosphohistidine phosphatase, SixA
CAI17_15695	COG0489	protein tyrosine kinase activity
CAI17_15750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CAI17_15765	COG1125	glycine betaine transport
CAI17_15780	COG1119	ATPase activity
CAI17_15790	COG1752	Esterase of the alpha-beta hydrolase superfamily
CAI17_15800	COG1522	sequence-specific DNA binding
CAI17_15805	COG3186	Phenylalanine-4-hydroxylase
CAI17_15820	COG2755	lipolytic protein G-D-S-L family
CAI17_15830	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_15835	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CAI17_15845	COG1609	Transcriptional regulator
CAI17_15850	COG3507	Belongs to the glycosyl hydrolase 43 family
CAI17_15865	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAI17_15875	COG0657	acetylesterase activity
CAI17_15875	COG2755	lipolytic protein G-D-S-L family
CAI17_15895	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CAI17_15900	COG0366	Alpha amylase catalytic
CAI17_15905	COG0366	Alpha amylase catalytic
CAI17_15990	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CAI17_16025	COG2937	Belongs to the GPAT DAPAT family
CAI17_16060	COG0284	orotidine-5'-phosphate decarboxylase activity
CAI17_16065	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CAI17_16075	COG3132	Protein of unknown function, DUF480
CAI17_16090	COG0210	DNA helicase
CAI17_16110	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CAI17_16140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CAI17_16145	COG0739	heme binding
CAI17_16150	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CAI17_16160	COG2211	Major facilitator Superfamily
CAI17_16165	COG0708	Exodeoxyribonuclease III
CAI17_16170	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CAI17_16180	COG1192	Involved in chromosome partitioning
CAI17_16185	COG1475	DNA binding
CAI17_16225	COG0756	dUTP diphosphatase activity
CAI17_16230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CAI17_16235	COG2003	Belongs to the UPF0758 family
CAI17_16240	COG0018	arginyl-trna synthetase
CAI17_16255	COG4221	oxidoreductase activity
CAI17_16260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CAI17_16260	COG2755	lipolytic protein G-D-S-L family
CAI17_16270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAI17_16275	COG1166	arginine decarboxylase activity
CAI17_16280	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CAI17_16330	COG2960	long-chain fatty acid transporting porin activity
CAI17_16335	COG0606	chelatase, subunit chli
CAI17_16350	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CAI17_16385	COG1690	Belongs to the RtcB family
CAI17_16420	COG1090	epimerase
CAI17_16425	COG0745	RESPONSE REGULATOR receiver
CAI17_16430	COG0642	Histidine kinase
CAI17_16460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAI17_16485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAI17_16490	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CAI17_16505	COG0753	catalase activity
CAI17_16530	COG2197	response regulator
CAI17_16535	COG4585	Histidine kinase
CAI17_16540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI17_16545	COG1136	(ABC) transporter
CAI17_16575	COG0697	spore germination
CAI17_16595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAI17_16600	COG0180	Tryptophanyl-tRNA synthetase
CAI17_16605	COG3237	CsbD-like
CAI17_16650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CAI17_16700	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CAI17_16705	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CAI17_16705	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CAI17_16735	COG2205	protein histidine kinase activity
CAI17_16740	COG0745	RESPONSE REGULATOR receiver
CAI17_16750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CAI17_16780	COG1199	ATP-dependent helicase activity
CAI17_16795	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CAI17_16860	COG0625	glutathione transferase activity
CAI17_16900	COG4555	ABC transporter
CAI17_16910	COG1476	TRANSCRIPTIONal
CAI17_16955	COG0543	2 iron, 2 sulfur cluster binding
CAI17_16955	COG0633	Ferredoxin
CAI17_16960	COG1131	(ABC) transporter
CAI17_16965	COG0842	Transport permease protein
CAI17_16975	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CAI17_17010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAI17_17020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAI17_17035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CAI17_17035	COG0045	succinate-CoA ligase (ADP-forming) activity
CAI17_17035	COG1042	CoA-binding domain protein
CAI17_17040	COG2239	Acts as a magnesium transporter
CAI17_17060	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CAI17_17065	COG3387	PFAM Glycoside hydrolase 15-related
CAI17_17080	COG3100	YcgL domain-containing protein
CAI17_17085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAI17_17095	COG0463	Glycosyl transferase, family 2
CAI17_17105	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_17145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CAI17_17160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CAI17_17190	COG1506	peptidase
CAI17_17190	COG0823	Involved in the tonB-independent uptake of proteins
CAI17_17190	COG4946	Tricorn protease homolog
CAI17_17210	COG0408	coproporphyrinogen oxidase activity
CAI17_17250	COG0515	serine threonine protein kinase
CAI17_17255	COG0631	protein serine/threonine phosphatase activity
CAI17_17290	COG3501	Rhs element vgr protein
CAI17_17450	COG0210	DNA helicase
CAI17_17465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAI17_17470	COG0583	DNA-binding transcription factor activity
CAI17_17475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAI17_17490	COG2159	amidohydrolase
CAI17_17520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI17_17540	COG0357	Ribosomal RNA small subunit methyltransferase G
CAI17_17545	COG3540	Alkaline phosphatase
CAI17_17555	COG2091	lysine biosynthetic process via aminoadipic acid
CAI17_17570	COG0708	Exodeoxyribonuclease III
CAI17_17575	COG1940	carbohydrate kinase activity
CAI17_17575	COG1846	Transcriptional regulator
CAI17_17585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAI17_17595	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CAI17_17600	COG3162	membrane
CAI17_17610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CAI17_17650	COG3507	Belongs to the glycosyl hydrolase 43 family
CAI17_17670	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_17675	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAI17_17685	COG4948	Mandelate Racemase Muconate Lactonizing
CAI17_17690	COG3254	rhamnose metabolic process
CAI17_17695	COG0738	Major facilitator superfamily
CAI17_17700	COG1414	Transcriptional regulator
CAI17_17710	COG1971	Probably functions as a manganese efflux pump
CAI17_17715	COG2205	protein histidine kinase activity
CAI17_17730	COG3459	Glycosyltransferase 36 associated
CAI17_17735	COG2211	Major facilitator Superfamily
CAI17_17740	COG3265	gluconokinase activity
CAI17_17750	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAI17_17770	COG2911	Protein conserved in bacteria
CAI17_17775	COG0729	surface antigen
CAI17_17825	COG0752	glycyl-tRNA synthetase alpha subunit
CAI17_17845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CAI17_17845	COG0519	Catalyzes the synthesis of GMP from XMP
CAI17_17855	COG0805	protein transport
CAI17_17860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CAI17_17865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CAI17_17875	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CAI17_17900	COG2974	May be involved in recombination
CAI17_17905	COG0037	tRNA processing
CAI17_17915	COG2115	Belongs to the xylose isomerase family
CAI17_17935	COG4948	Mandelate Racemase Muconate Lactonizing
CAI17_17945	COG1472	Belongs to the glycosyl hydrolase 3 family
CAI17_17950	COG0246	Mannitol dehydrogenase
CAI17_17995	COG3002	Belongs to the UPF0753 family
CAI17_18050	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CAI17_18120	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CAI17_18140	COG0662	Cupin 2, conserved barrel domain protein
CAI17_18160	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CAI17_18190	COG0714	Associated with various cellular activities
CAI17_18230	COG0477	Major facilitator Superfamily
CAI17_18240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CAI17_18285	COG3237	CsbD-like
CAI17_18310	COG2249	NAD(P)H dehydrogenase (quinone) activity
CAI17_18325	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_18330	COG0300	oxidoreductase activity
CAI17_18350	COG1272	protein, Hemolysin III
CAI17_18355	COG1205	dead DEAH box helicase
CAI17_18355	COG1111	helicase
CAI17_18455	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CAI17_18485	COG1132	(ABC) transporter
CAI17_18535	COG0297	glycogen (starch) synthase activity
CAI17_18535	COG0438	transferase activity, transferring glycosyl groups
CAI17_18565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CAI17_18615	COG0069	glutamate synthase activity
CAI17_18615	COG0070	glutamate synthase
CAI17_18615	COG0067	glutamate synthase
CAI17_18620	COG0493	'glutamate synthase
CAI17_18625	COG1064	alcohol dehydrogenase
CAI17_18635	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CAI17_18645	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CAI17_18655	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CAI17_18665	COG2234	aminopeptidase activity
CAI17_18675	COG4942	peptidase
CAI17_18680	COG0793	Belongs to the peptidase S41A family
CAI17_18735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAI17_18745	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CAI17_18775	COG0501	Belongs to the peptidase M48B family
CAI17_18785	COG0187	DNA topoisomerase II activity
CAI17_18790	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CAI17_18800	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CAI17_18810	COG0594	ribonuclease P activity
CAI17_18815	COG0706	membrane insertase activity
CAI17_18820	COG0726	polysaccharide deacetylase
CAI17_18825	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CAI17_18840	COG0584	glycerophosphoryl diester phosphodiesterase
CAI17_18855	COG0861	Integral membrane protein TerC family
CAI17_18865	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CAI17_18910	COG0531	amino acid
CAI17_18920	COG0625	glutathione transferase activity
CAI17_18935	COG0583	DNA-binding transcription factor activity
CAI17_18940	COG0604	alcohol dehydrogenase
CAI17_18945	COG1322	Protein conserved in bacteria
CAI17_18955	COG0386	Belongs to the glutathione peroxidase family
CAI17_18965	COG2853	Lipoprotein
CAI17_18980	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CAI17_18985	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CAI17_18990	COG1127	ABC transporter
CAI17_19005	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CAI17_19010	COG1074	ATP-dependent DNA helicase activity
CAI17_19030	COG3039	Transposase
CAI17_19105	COG0564	pseudouridine synthase activity
CAI17_19145	COG1309	transcriptional regulator
CAI17_19155	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_19175	COG1487	ribonuclease activity
CAI17_19180	COG4691	Plasmid stability protein
CAI17_19200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAI17_19210	COG0477	Major facilitator Superfamily
CAI17_19215	COG1289	transmembrane transporter activity
CAI17_19225	COG1566	PFAM secretion protein HlyD family protein
CAI17_19240	COG0302	gtp cyclohydrolase
CAI17_19260	COG0730	response to heat
CAI17_19265	COG3012	SEC-C Motif Domain Protein
CAI17_19275	COG0676	glucose-6-phosphate 1-epimerase activity
CAI17_19300	COG3135	benzoate transporter
CAI17_19340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CAI17_19355	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CAI17_19385	COG0109	protoheme IX farnesyltransferase activity
CAI17_19400	COG0358	DNA primase activity
CAI17_19405	COG1295	ribonuclease BN
CAI17_19415	COG1610	YqeY-like protein
CAI17_19425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CAI17_19430	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CAI17_19440	COG2133	pyrroloquinoline quinone binding
CAI17_19445	COG4682	membrane
CAI17_19460	COG0531	amino acid
CAI17_19470	COG4948	Mandelate Racemase Muconate Lactonizing
CAI17_19480	COG3023	N-Acetylmuramoyl-L-alanine amidase
CAI17_19485	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CAI17_19535	COG5383	Protein conserved in bacteria
CAI17_19545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAI17_19550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI17_19555	COG1473	amidohydrolase
CAI17_19560	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CAI17_19560	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CAI17_19565	COG1652	LysM domain
CAI17_19575	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CAI17_19580	COG1518	maintenance of DNA repeat elements
CAI17_19625	COG0583	DNA-binding transcription factor activity
CAI17_19630	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CAI17_19635	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CAI17_19640	COG3118	belongs to the thioredoxin family
CAI17_19645	COG0513	Belongs to the DEAD box helicase family
CAI17_19650	COG2884	Cell division ATP-binding protein ftsE
CAI17_19655	COG2177	Part of the ABC transporter FtsEX involved in
CAI17_19660	COG3437	response regulator, receiver
CAI17_19665	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CAI17_19670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CAI17_19680	COG1252	NADH dehydrogenase
CAI17_19695	COG0625	glutathione transferase activity
CAI17_19700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CAI17_19720	COG0534	Mate efflux family protein
CAI17_19725	COG0616	signal peptide processing
CAI17_19735	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_19750	COG0009	L-threonylcarbamoyladenylate synthase
CAI17_19755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CAI17_19755	COG1754	DNA topoisomerase type I activity
CAI17_19775	COG0758	DNA mediated transformation
CAI17_19780	COG1652	LysM domain
CAI17_19785	COG0242	peptide deformylase activity
CAI17_19790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CAI17_19795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CAI17_19795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CAI17_19850	COG1560	Kdo2-lipid A biosynthetic process
CAI17_19855	COG1490	D-aminoacyl-tRNA deacylase activity
CAI17_19860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CAI17_19935	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CAI17_19940	COG0583	DNA-binding transcription factor activity
CAI17_19955	COG0840	transmembrane signaling receptor activity
CAI17_19970	COG0251	oxidation-reduction process
CAI17_20045	COG1063	alcohol dehydrogenase
CAI17_20070	COG1132	(ABC) transporter
CAI17_20100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CAI17_20105	COG1028	Short-chain dehydrogenase reductase Sdr
CAI17_20125	COG1294	oxidase, subunit
CAI17_20130	COG1271	oxidase subunit
CAI17_20180	COG3546	catalase activity
CAI17_20185	COG3685	Protein conserved in bacteria
CAI17_20210	COG2972	Histidine kinase
CAI17_20225	COG0531	amino acid
CAI17_20245	COG3590	peptidase
CAI17_20260	COG0667	Aldo Keto reductase
CAI17_20280	COG3384	dioxygenase
CAI17_20290	COG1573	uracil-dna glycosylase
CAI17_20295	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CAI17_20305	COG0025	NhaP-type Na H and K H
CAI17_20310	COG1131	(ABC) transporter
CAI17_20315	COG0842	Transport permease protein
CAI17_20375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAI17_20380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CAI17_20400	COG2205	protein histidine kinase activity
CAI17_20400	COG2202	Pas domain
CAI17_20420	COG2813	Specifically methylates the guanine in position
CAI17_20425	COG1187	pseudouridine synthase activity
CAI17_20430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAI17_20455	COG0784	Response regulator, receiver
CAI17_20455	COG5002	protein histidine kinase activity
CAI17_20455	COG2198	Histidine kinase
CAI17_20465	COG1666	GTP binding
CAI17_20470	COG0697	spore germination
CAI17_20475	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CAI17_20480	COG2011	ABC-type metal ion transport system permease component
CAI17_20525	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAI17_20535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAI17_20555	COG0356	it plays a direct role in the translocation of protons across the membrane
CAI17_20565	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CAI17_20570	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CAI17_20575	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CAI17_20580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CAI17_20585	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CAI17_20590	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CAI17_20605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CAI17_20610	COG4191	Histidine kinase
CAI17_20625	COG0577	efflux transmembrane transporter activity
CAI17_20630	COG0577	efflux transmembrane transporter activity
CAI17_20635	COG4591	ABC-type transport system involved in lipoprotein release permease component
CAI17_20635	COG1136	(ABC) transporter
CAI17_20640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI17_20645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CAI17_20685	COG2132	Multicopper oxidase
CAI17_20700	COG0339	signal peptide processing
CAI17_20715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CAI17_20720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CAI17_20735	COG2819	hydrolase of the alpha beta superfamily
CAI17_20745	COG1956	GAF domain-containing protein
CAI17_20755	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CAI17_20765	COG0720	synthase
CAI17_20775	COG4206	TonB-dependent receptor
CAI17_20785	COG0513	Belongs to the DEAD box helicase family
CAI17_20800	COG0625	glutathione transferase activity
CAI17_20830	COG0626	cystathionine gamma-synthase activity
CAI17_20850	COG0438	transferase activity, transferring glycosyl groups
CAI17_20850	COG1216	Glycosyl transferase, family 2
CAI17_20885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAI17_20900	COG0277	FAD linked oxidase domain protein
CAI17_20905	COG0546	phosphoglycolate phosphatase activity
CAI17_20905	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CAI17_20920	COG2086	electron transfer activity
CAI17_20950	COG0662	Cupin 2, conserved barrel domain protein
CAI17_20950	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CAI17_20955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAI17_20990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CAI17_20990	COG3218	ABC-type transport auxiliary lipoprotein component
CAI17_20995	COG1127	ABC transporter
CAI17_21000	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CAI17_21015	COG0442	prolyl-tRNA aminoacylation
CAI17_21025	COG1183	phosphatidylcholine synthase activity
CAI17_21045	COG0741	lytic transglycosylase activity
CAI17_21065	COG0525	valine-tRNA ligase activity
CAI17_21080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CAI17_21090	COG0795	lipopolysaccharide-transporting ATPase activity
CAI17_21105	COG4974	Belongs to the 'phage' integrase family
CAI17_21115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CAI17_21125	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CAI17_21125	COG0047	phosphoribosylformylglycinamidine synthase activity
CAI17_21130	COG5295	Hep Hag repeat protein
CAI17_21135	COG1404	Belongs to the peptidase S8 family
CAI17_21140	COG5295	Hep Hag repeat protein
CAI17_21145	COG1404	Belongs to the peptidase S8 family
CAI17_21150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CAI17_21160	COG1459	type II secretion system
CAI17_21165	COG2165	general secretion pathway protein
CAI17_21170	COG4970	Tfp pilus assembly protein FimT
CAI17_21175	COG2165	general secretion pathway protein
CAI17_21180	COG4795	General secretion pathway protein
CAI17_21185	COG3156	type II secretion system protein K
CAI17_21190	COG3166	PFAM Fimbrial assembly family protein
CAI17_21205	COG1450	Type ii and iii secretion system protein
CAI17_21220	COG2188	Transcriptional regulator
CAI17_21285	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CAI17_21300	COG1215	transferase activity, transferring glycosyl groups
CAI17_21305	COG1215	transferase activity, transferring glycosyl groups
CAI17_21310	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CAI17_21315	COG0457	Tetratricopeptide repeat
CAI17_21345	COG0242	peptide deformylase activity
CAI17_21350	COG1307	EDD domain protein, DegV family
CAI17_21385	COG0402	S-adenosylhomocysteine deaminase activity
CAI17_21390	COG3964	amidohydrolase
CAI17_21405	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CAI17_21410	COG0726	polysaccharide deacetylase
CAI17_21440	COG0436	Aminotransferase
CAI17_21460	COG0237	dephospho-CoA kinase activity
CAI17_21465	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CAI17_21470	COG1459	type II secretion system
CAI17_21515	COG0045	succinate-CoA ligase (ADP-forming) activity
CAI17_21520	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CAI17_21530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CAI17_21530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CAI17_21540	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAI17_21545	COG0564	pseudouridine synthase activity
CAI17_21560	COG3011	Protein conserved in bacteria
CAI17_21565	COG0840	transmembrane signaling receptor activity
CAI17_21585	COG3387	PFAM Glycoside hydrolase 15-related
CAI17_21590	COG1877	trehalose-phosphatase activity
CAI17_21635	COG2827	Endonuclease containing a URI domain
CAI17_21645	COG4771	TonB-dependent receptor
CAI17_21650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAI17_21655	COG0667	Aldo Keto reductase
CAI17_21660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAI17_21665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAI17_21670	COG1116	anion transmembrane transporter activity
CAI17_21675	COG0542	response to heat
CAI17_21680	COG4206	TonB-dependent receptor
CAI17_21710	COG1492	cobalamin metabolic process
CAI17_21720	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CAI17_21750	COG0019	diaminopimelate decarboxylase activity
CAI17_21765	COG4264	IucA IucC family
CAI17_21775	COG4772	TonB-dependent receptor
CAI17_21800	COG4651	solute:proton antiporter activity
CAI17_21800	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CAI17_21840	COG0488	(ABC) transporter
CAI17_21885	COG0477	Major facilitator Superfamily
CAI17_21900	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CAI17_21915	COG0217	transcriptional regulatory protein
CAI17_21920	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CAI17_21925	COG0632	four-way junction helicase activity
CAI17_21930	COG3158	transport of potassium into the cell
CAI17_21940	COG2255	four-way junction helicase activity
CAI17_21945	COG0824	Thioesterase
CAI17_21955	COG0848	biopolymer transport protein
CAI17_21965	COG0823	Involved in the tonB-independent uptake of proteins
CAI17_21970	COG2885	chlorophyll binding
CAI17_21980	COG0602	queuosine metabolic process
CAI17_21990	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CAI17_21995	COG3920	Histidine kinase
CAI17_22015	COG0840	transmembrane signaling receptor activity
CAI17_22050	COG0514	ATP-dependent DNA helicase (RecQ)
CAI17_22060	COG0783	Belongs to the Dps family
CAI17_22065	COG1643	Atp-dependent helicase
CAI17_22090	COG0535	radical SAM domain protein
CAI17_22095	COG0535	radical SAM domain protein
CAI17_22100	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CAI17_22105	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CAI17_22115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CAI17_22135	COG1215	transferase activity, transferring glycosyl groups
CAI17_22140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CAI17_22150	COG1199	ATP-dependent helicase activity
CAI17_22160	COG1397	ADP-ribosylglycohydrolase
CAI17_22170	COG0189	ligase activity
CAI17_22185	COG0835	chemotaxis
CAI17_22190	COG0840	transmembrane signaling receptor activity
CAI17_22195	COG0643	Histidine kinase
CAI17_22195	COG0784	Response regulator, receiver
CAI17_22195	COG2198	Histidine kinase
CAI17_22225	COG1446	asparaginase
CAI17_22230	COG3142	Participates in the control of copper homeostasis
CAI17_22270	COG3537	Alpha-1,2-mannosidase
CAI17_22305	COG1472	Belongs to the glycosyl hydrolase 3 family
CAI17_22320	COG1388	LysM domain
CAI17_22320	COG3858	chitin binding
CAI17_22335	COG0837	glucose binding
CAI17_22340	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CAI17_22350	COG0494	nUDIX hydrolase
CAI17_22360	COG3956	TIGRFAM MazG family protein
CAI17_22365	COG1742	UPF0060 membrane protein
CAI17_22390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CAI17_22395	COG0509	glycine decarboxylation via glycine cleavage system
CAI17_22420	COG1960	acyl-CoA dehydrogenase activity
CAI17_22430	COG1309	transcriptional regulator
CAI17_22445	COG4771	TonB-dependent receptor
CAI17_22455	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CAI17_22460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CAI17_22465	COG0463	Glycosyl transferase, family 2
CAI17_22470	COG0516	GMP reductase activity
CAI17_22470	COG0517	IMP dehydrogenase activity
CAI17_22475	COG2982	Protein involved in outer membrane biogenesis
CAI17_22480	COG1272	protein, Hemolysin III
CAI17_22485	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CAI17_22490	COG0739	heme binding
CAI17_22495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAI17_22500	COG0626	cystathionine gamma-synthase activity
CAI17_22505	COG0460	homoserine dehydrogenase
CAI17_22505	COG0527	aspartate kinase activity
CAI17_22520	COG1760	l-serine dehydratase
CAI17_22540	COG2353	YceI-like domain
CAI17_22545	COG0784	Response regulator, receiver
CAI17_22545	COG2198	Histidine kinase
CAI17_22545	COG2205	protein histidine kinase activity
CAI17_22565	COG0477	Major facilitator Superfamily
CAI17_22570	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CAI17_22580	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CAI17_22585	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CAI17_22590	COG0259	pyridoxamine-phosphate oxidase activity
CAI17_22600	COG1842	Phage shock protein A
CAI17_22625	COG0754	glutathionylspermidine amidase activity
CAI17_22635	COG2814	Major facilitator Superfamily
CAI17_22700	COG1234	tRNA 3'-trailer cleavage
CAI17_22730	COG0531	amino acid
CAI17_22735	COG2197	response regulator
CAI17_22765	COG1113	amino acid transport
CAI17_22785	COG1271	oxidase subunit
CAI17_22790	COG1294	oxidase, subunit
CAI17_22805	COG2239	Acts as a magnesium transporter
CAI17_22815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CAI17_22820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAI17_22830	COG1660	Displays ATPase and GTPase activities
CAI17_22835	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CAI17_22840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAI17_22855	COG1137	ATPase activity
CAI17_22860	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CAI17_22870	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CAI17_22880	COG0271	Belongs to the BolA IbaG family
CAI17_22885	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CAI17_22905	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CAI17_22915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CAI17_23130	COG1192	Involved in chromosome partitioning
CAI17_23245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAI17_23260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CAI17_23310	COG3318	Belongs to the UPF0149 family
CAI17_23310	COG3012	SEC-C Motif Domain Protein
CAI17_23320	COG1487	ribonuclease activity
CAI17_23325	COG4691	Plasmid stability protein
CAI17_23540	COG2948	multi-organism process
CAI17_23545	COG3504	Conjugal transfer protein
CAI17_23555	COG3704	protein secretion by the type IV secretion system
CAI17_23655	COG1192	Involved in chromosome partitioning