locus-tag	class	description
XapA_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XapA_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XapA_00020	COG0187	DNA topoisomerase II activity
XapA_00030	COG0501	Belongs to the peptidase M48B family
XapA_00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XapA_00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XapA_00125	COG0793	Belongs to the peptidase S41A family
XapA_00130	COG4942	peptidase
XapA_00140	COG2234	aminopeptidase activity
XapA_00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XapA_00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XapA_00170	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XapA_00180	COG1064	alcohol dehydrogenase
XapA_00185	COG0493	'glutamate synthase
XapA_00190	COG0069	glutamate synthase activity
XapA_00190	COG0067	glutamate synthase
XapA_00190	COG0070	glutamate synthase
XapA_00240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
XapA_00270	COG0438	transferase activity, transferring glycosyl groups
XapA_00270	COG0297	glycogen (starch) synthase activity
XapA_00320	COG1132	(ABC) transporter
XapA_00350	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XapA_00450	COG1111	helicase
XapA_00450	COG1205	dead DEAH box helicase
XapA_00455	COG1272	protein, Hemolysin III
XapA_00475	COG0300	oxidoreductase activity
XapA_00480	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_00495	COG2249	NAD(P)H dehydrogenase (quinone) activity
XapA_00505	COG1487	ribonuclease activity
XapA_00510	COG4691	Plasmid stability protein
XapA_00530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XapA_00540	COG0477	Major facilitator Superfamily
XapA_00545	COG1289	transmembrane transporter activity
XapA_00555	COG1566	PFAM secretion protein HlyD family protein
XapA_00570	COG0302	gtp cyclohydrolase
XapA_00590	COG0730	response to heat
XapA_00595	COG3012	SEC-C Motif Domain Protein
XapA_00605	COG0676	glucose-6-phosphate 1-epimerase activity
XapA_00630	COG3135	benzoate transporter
XapA_00660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XapA_00680	COG0210	DNA helicase
XapA_00695	COG3132	Protein of unknown function, DUF480
XapA_00705	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
XapA_00710	COG0284	orotidine-5'-phosphate decarboxylase activity
XapA_00745	COG2937	Belongs to the GPAT DAPAT family
XapA_00780	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XapA_00865	COG0366	Alpha amylase catalytic
XapA_00870	COG0366	Alpha amylase catalytic
XapA_00875	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XapA_00895	COG0657	acetylesterase activity
XapA_00895	COG2755	lipolytic protein G-D-S-L family
XapA_00905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XapA_00920	COG3507	Belongs to the glycosyl hydrolase 43 family
XapA_00925	COG1609	Transcriptional regulator
XapA_00935	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
XapA_00940	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_00950	COG2755	lipolytic protein G-D-S-L family
XapA_00965	COG3186	Phenylalanine-4-hydroxylase
XapA_00970	COG1522	sequence-specific DNA binding
XapA_00980	COG1752	Esterase of the alpha-beta hydrolase superfamily
XapA_00990	COG1119	ATPase activity
XapA_01005	COG1125	glycine betaine transport
XapA_01020	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XapA_01075	COG0489	protein tyrosine kinase activity
XapA_01080	COG2062	phosphohistidine phosphatase, SixA
XapA_01090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XapA_01140	COG1968	undecaprenyl-diphosphatase activity
XapA_01150	COG0174	glutamine synthetase
XapA_01155	COG0347	Belongs to the P(II) protein family
XapA_01160	COG0004	ammonium transporteR
XapA_01165	COG3852	Histidine kinase
XapA_01170	COG2204	response regulator
XapA_01175	COG2032	superoxide dismutase activity
XapA_01180	COG2032	superoxide dismutase activity
XapA_01195	COG0183	Belongs to the thiolase family
XapA_01230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XapA_01235	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XapA_01240	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XapA_01295	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XapA_01300	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XapA_01305	COG4786	Flagellar basal body rod
XapA_01310	COG4786	Flagellar basal body rod
XapA_01325	COG1706	bacterial-type flagellum-dependent cell motility
XapA_01340	COG1677	Flagellar hook-basal body complex protein FliE
XapA_01345	COG1766	The M ring may be actively involved in energy transduction
XapA_01360	COG1157	protein secretion by the type III secretion system
XapA_01385	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XapA_01420	COG0028	Belongs to the TPP enzyme family
XapA_01425	COG2205	protein histidine kinase activity
XapA_01450	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XapA_01465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XapA_01475	COG0596	Alpha beta hydrolase
XapA_01480	COG0727	PFAM Uncharacterised protein family (UPF0153)
XapA_01485	COG0318	PFAM AMP-dependent synthetase and ligase
XapA_01490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XapA_01505	COG1181	Belongs to the D-alanine--D-alanine ligase family
XapA_01515	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XapA_01525	COG0564	pseudouridine synthase activity
XapA_01545	COG1446	asparaginase
XapA_01550	COG0339	signal peptide processing
XapA_01580	COG0475	glutathione-regulated potassium exporter activity
XapA_01585	COG0583	DNA-binding transcription factor activity
XapA_01590	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XapA_01595	COG2224	Isocitrate lyase
XapA_01600	COG3706	GGDEF domain
XapA_01635	COG4770	biotin carboxylase activity
XapA_01640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XapA_01645	COG1960	acyl-CoA dehydrogenase activity
XapA_01650	COG1309	transcriptional regulator
XapA_01705	COG0523	cobalamin synthesis protein
XapA_01725	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XapA_01730	COG1846	Transcriptional regulator
XapA_01735	COG1764	response to oxidative stress
XapA_01765	COG2130	NADP-dependent
XapA_01780	COG1187	pseudouridine synthase activity
XapA_01795	COG1643	Atp-dependent helicase
XapA_01800	COG4807	Protein conserved in bacteria
XapA_01805	COG2351	hydroxyisourate hydrolase activity
XapA_01810	COG2072	flavoprotein involved in K transport
XapA_01830	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XapA_01865	COG1957	nucleoside hydrolase
XapA_01875	COG2252	PERMEase
XapA_01900	COG0084	hydrolase, TatD family'
XapA_01920	COG0583	DNA-binding transcription factor activity
XapA_01925	COG2814	Major facilitator Superfamily
XapA_01940	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XapA_01945	COG1902	pentaerythritol trinitrate reductase activity
XapA_01965	COG0745	RESPONSE REGULATOR receiver
XapA_01970	COG2205	protein histidine kinase activity
XapA_01975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapA_02000	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XapA_02005	COG0583	DNA-binding transcription factor activity
XapA_02040	COG0702	epimerase
XapA_02045	COG1733	regulation of RNA biosynthetic process
XapA_02090	COG0129	dihydroxy-acid dehydratase activity
XapA_02105	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XapA_02165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XapA_02170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XapA_02200	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XapA_02205	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XapA_02215	COG3485	protocatechuate 3,4-dioxygenase
XapA_02230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XapA_02235	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XapA_02245	COG1414	Transcriptional regulator
XapA_02265	COG0445	tRNA wobble uridine modification
XapA_02305	COG2267	carboxylic ester hydrolase activity
XapA_02315	COG0156	8-amino-7-oxononanoate synthase activity
XapA_02320	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XapA_02325	COG1040	competence protein
XapA_02330	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XapA_02420	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XapA_02490	COG1511	domain protein
XapA_02490	COG3264	Mechanosensitive ion channel
XapA_02495	COG1368	sulfuric ester hydrolase activity
XapA_02505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XapA_02510	COG2354	Protein conserved in bacteria
XapA_02520	COG0297	glycogen (starch) synthase activity
XapA_02525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XapA_02530	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XapA_02555	COG0702	epimerase
XapA_02560	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_02595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XapA_02600	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_02615	COG0513	Belongs to the DEAD box helicase family
XapA_02635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
XapA_02650	COG3483	tryptophan 2,3-dioxygenase activity
XapA_02655	COG3104	oligopeptide transport
XapA_02680	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
XapA_02700	COG1320	monovalent cation:proton antiporter activity
XapA_02705	COG2212	antiporter activity
XapA_02715	COG0651	ATP synthesis coupled electron transport
XapA_02720	COG1006	Multisubunit Na H antiporter MnhC subunit
XapA_02725	COG2111	Na H antiporter
XapA_02725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XapA_02750	COG3179	chitinase
XapA_02770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XapA_02775	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XapA_02790	COG0456	acetyltransferase
XapA_02795	COG1597	lipid kinase activity
XapA_02820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XapA_02825	COG0134	indole-3-glycerol-phosphate synthase activity
XapA_02835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XapA_02840	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XapA_02850	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XapA_02860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XapA_02875	COG1051	belongs to the nudix hydrolase family
XapA_02915	COG0316	Belongs to the HesB IscA family
XapA_02935	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XapA_02955	COG2814	Major facilitator Superfamily
XapA_02965	COG2814	Major facilitator Superfamily
XapA_02970	COG1289	transmembrane transporter activity
XapA_02980	COG0151	Belongs to the GarS family
XapA_02990	COG0138	bifunctional purine biosynthesis protein purh
XapA_02995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XapA_03000	COG2267	carboxylic ester hydrolase activity
XapA_03005	COG2453	phosphatase
XapA_03005	COG0671	phosphoesterase, PA-phosphatase related
XapA_03030	COG4589	Belongs to the CDS family
XapA_03035	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XapA_03060	COG2264	protein methyltransferase activity
XapA_03080	COG0439	Biotin carboxylase
XapA_03090	COG0511	ligase activity, forming carbon-carbon bonds
XapA_03095	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XapA_03105	COG1324	tolerance protein
XapA_03135	COG0300	oxidoreductase activity
XapA_03145	COG2356	endonuclease I
XapA_03155	COG0459	protein refolding
XapA_03170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XapA_03185	COG3386	PFAM SMP-30 Gluconolaconase
XapA_03195	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XapA_03200	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XapA_03220	COG0778	Nitroreductase
XapA_03225	COG2353	YceI-like domain
XapA_03255	COG3052	prosthetic group binding
XapA_03290	COG1802	Transcriptional regulator
XapA_03365	COG4221	oxidoreductase activity
XapA_03380	COG4221	oxidoreductase activity
XapA_03395	COG0435	Glutathione S-transferase
XapA_03420	COG2409	Drug exporters of the RND superfamily
XapA_03430	COG1506	peptidase
XapA_03430	COG0823	Involved in the tonB-independent uptake of proteins
XapA_03450	COG3706	GGDEF domain
XapA_03475	COG0697	spore germination
XapA_03490	COG1113	amino acid transport
XapA_03510	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
XapA_03560	COG5001	Diguanylate cyclase
XapA_03570	COG0840	transmembrane signaling receptor activity
XapA_03575	COG5297	Belongs to the glycosyl hydrolase family 6
XapA_03575	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XapA_03580	COG0659	secondary active sulfate transmembrane transporter activity
XapA_03590	COG3706	GGDEF domain
XapA_03610	COG2943	transferase activity, transferring hexosyl groups
XapA_03620	COG3275	phosphorelay sensor kinase activity
XapA_03630	COG0181	hydroxymethylbilane synthase activity
XapA_03670	COG1505	serine-type exopeptidase activity
XapA_03690	COG2832	Protein of unknown function (DUF454)
XapA_03700	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XapA_03710	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XapA_03715	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XapA_03720	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XapA_03745	COG2226	methyltransferase
XapA_03750	COG2199	diguanylate cyclase activity
XapA_03755	COG0308	aminopeptidase N
XapA_03790	COG1162	GTPase activity
XapA_03815	COG2211	Major facilitator Superfamily
XapA_03820	COG1609	Transcriptional regulator
XapA_03825	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_03830	COG2851	Citrate transporter
XapA_03850	COG0642	Histidine kinase
XapA_03865	COG2197	response regulator
XapA_03885	COG0667	Aldo Keto reductase
XapA_03895	COG0583	DNA-binding transcription factor activity
XapA_03925	COG1301	dicarboxylic acid transport
XapA_03930	COG0281	malic enzyme
XapA_03930	COG0280	phosphate acetyltransferase
XapA_03955	COG1560	Kdo2-lipid A biosynthetic process
XapA_03960	COG1519	Transferase
XapA_03965	COG1538	Outer membrane efflux protein
XapA_03970	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XapA_03990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XapA_03995	COG0066	3-isopropylmalate dehydratase activity
XapA_04000	COG0473	3-isopropylmalate dehydrogenase activity
XapA_04005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XapA_04025	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XapA_04035	COG0840	transmembrane signaling receptor activity
XapA_04050	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XapA_04055	COG3710	Transcriptional regulator
XapA_04085	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XapA_04095	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XapA_04120	COG0563	adenylate kinase activity
XapA_04125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XapA_04135	COG3781	membrane
XapA_04140	COG0671	phosphoesterase, PA-phosphatase related
XapA_04150	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_04160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XapA_04165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XapA_04195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XapA_04210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XapA_04225	COG0352	thiamine-phosphate diphosphorylase activity
XapA_04230	COG1773	rubredoxin
XapA_04235	COG2912	Transglutaminase-like superfamily
XapA_04245	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XapA_04255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XapA_04275	COG3079	Belongs to the UPF0149 family
XapA_04280	COG0006	proline dipeptidase activity
XapA_04290	COG0006	proline dipeptidase activity
XapA_04305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XapA_04310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XapA_04320	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XapA_04325	COG1561	YicC-like family, N-terminal region
XapA_04330	COG0194	GDP metabolic process
XapA_04340	COG1070	Carbohydrate kinase
XapA_04345	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_04365	COG3659	wide pore channel activity
XapA_04380	COG2390	Transcriptional regulator
XapA_04385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XapA_04390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XapA_04400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XapA_04430	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XapA_04460	COG0714	Associated with various cellular activities
XapA_04480	COG2304	oxidoreductase activity
XapA_04495	COG1301	dicarboxylic acid transport
XapA_04500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XapA_04505	COG0596	Alpha beta hydrolase
XapA_04510	COG4773	Receptor
XapA_04520	COG0739	heme binding
XapA_04530	COG1376	ErfK ybiS ycfS ynhG family protein
XapA_04565	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XapA_04570	COG4149	molybdate abc transporter
XapA_04575	COG0725	ABC transporter, periplasmic molybdate-binding protein
XapA_04580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XapA_04580	COG3453	Protein conserved in bacteria
XapA_04590	COG3047	cAMP biosynthetic process
XapA_04595	COG3047	cAMP biosynthetic process
XapA_04610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XapA_04635	COG0126	phosphoglycerate kinase activity
XapA_04645	COG0469	pyruvate kinase activity
XapA_04650	COG3588	fructose-bisphosphate aldolase
XapA_04655	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
XapA_04670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XapA_04670	COG1648	precorrin-2 dehydrogenase activity
XapA_04690	COG0784	Response regulator, receiver
XapA_04690	COG2198	Histidine kinase
XapA_04690	COG2205	protein histidine kinase activity
XapA_04710	COG0175	sulfate reduction
XapA_04715	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XapA_04720	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XapA_04725	COG0175	sulfate reduction
XapA_04730	COG2895	sulfate adenylyltransferase (ATP) activity
XapA_04730	COG0529	Catalyzes the synthesis of activated sulfate
XapA_04735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapA_04740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XapA_04790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XapA_04805	COG4948	Mandelate Racemase Muconate Lactonizing
XapA_04810	COG3250	beta-galactosidase activity
XapA_04820	COG1609	Transcriptional regulator
XapA_04830	COG1970	mechanosensitive ion channel activity
XapA_04855	COG3273	potassium ion transport
XapA_04855	COG0471	metal ion transport
XapA_04860	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XapA_04870	COG2022	thiamine diphosphate biosynthetic process
XapA_04915	COG0189	ligase activity
XapA_04925	COG0745	RESPONSE REGULATOR receiver
XapA_04930	COG5002	protein histidine kinase activity
XapA_05040	COG2010	Cytochrome c
XapA_05060	COG3284	Transcriptional regulator
XapA_05065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XapA_05070	COG1077	Cell shape determining protein MreB Mrl
XapA_05075	COG1792	Involved in formation and maintenance of cell shape
XapA_05090	COG0772	Belongs to the SEDS family
XapA_05100	COG2951	lytic endotransglycosylase activity
XapA_05105	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XapA_05115	COG1686	Belongs to the peptidase S11 family
XapA_05125	COG2921	Belongs to the UPF0250 family
XapA_05130	COG0321	lipoyl(octanoyl) transferase activity
XapA_05135	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XapA_05150	COG0583	DNA-binding transcription factor activity
XapA_05160	COG1056	cytidyltransferase-related domain
XapA_05160	COG1051	belongs to the nudix hydrolase family
XapA_05195	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XapA_05200	COG0673	inositol 2-dehydrogenase activity
XapA_05205	COG2823	Periplasmic or secreted lipoprotein
XapA_05210	COG4251	negative regulation of phosphorylation
XapA_05215	COG0784	Response regulator, receiver
XapA_05220	COG4191	Histidine kinase
XapA_05225	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XapA_05285	COG1459	type II secretion system
XapA_05305	COG4795	General secretion pathway protein
XapA_05335	COG3250	beta-galactosidase activity
XapA_05350	COG2188	Transcriptional regulator
XapA_05360	COG1609	Transcriptional regulator
XapA_05365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XapA_05370	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XapA_05380	COG0617	tRNA 3'-terminal CCA addition
XapA_05385	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XapA_05390	COG1012	belongs to the aldehyde dehydrogenase family
XapA_05395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XapA_05410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XapA_05425	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XapA_05430	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XapA_05450	COG2205	protein histidine kinase activity
XapA_05455	COG0745	RESPONSE REGULATOR receiver
XapA_05480	COG3791	Glutathione-dependent formaldehyde-activating
XapA_05495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XapA_05505	COG0697	spore germination
XapA_05515	COG0488	(ABC) transporter
XapA_05525	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XapA_05530	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XapA_05540	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XapA_05540	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XapA_05560	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XapA_05565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XapA_05570	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XapA_05595	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XapA_05600	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XapA_05605	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
XapA_05610	COG2205	protein histidine kinase activity
XapA_05615	COG0745	RESPONSE REGULATOR receiver
XapA_05645	COG0277	FAD linked oxidase domain protein
XapA_05650	COG1988	membrane-bound metal-dependent
XapA_05655	COG0792	nuclease activity
XapA_05695	COG0275	rRNA processing
XapA_05700	COG3116	cell division
XapA_05710	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XapA_05715	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XapA_05720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XapA_05730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XapA_05735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XapA_05740	COG1181	Belongs to the D-alanine--D-alanine ligase family
XapA_05745	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XapA_05760	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XapA_05775	COG0653	protein targeting
XapA_05780	COG0494	nUDIX hydrolase
XapA_05790	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XapA_05805	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_05805	COG0604	alcohol dehydrogenase
XapA_05805	COG3321	synthase
XapA_05835	COG0366	Alpha amylase catalytic
XapA_05870	COG2226	methyltransferase
XapA_05875	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XapA_05885	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XapA_05935	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XapA_05945	COG4106	trans-aconitate 2-methyltransferase activity
XapA_05950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XapA_05960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XapA_05965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XapA_05975	COG0667	Aldo Keto reductase
XapA_05985	COG4771	TonB-dependent receptor
XapA_06005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XapA_06010	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XapA_06020	COG2175	clavaminate synthase activity
XapA_06030	COG4181	ATPase activity
XapA_06045	COG0642	Histidine kinase
XapA_06065	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XapA_06080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XapA_06085	COG2201	protein-glutamate methylesterase activity
XapA_06090	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XapA_06095	COG2200	EAL domain
XapA_06095	COG2199	diguanylate cyclase activity
XapA_06095	COG2202	Pas domain
XapA_06100	COG0835	chemotaxis
XapA_06105	COG0840	transmembrane signaling receptor activity
XapA_06110	COG0643	Histidine kinase
XapA_06110	COG2198	Histidine kinase
XapA_06120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XapA_06130	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XapA_06140	COG2205	protein histidine kinase activity
XapA_06145	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XapA_06155	COG4452	Inner membrane protein CreD
XapA_06180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XapA_06185	COG0735	belongs to the Fur family
XapA_06200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XapA_06220	COG2207	Transcriptional regulator
XapA_06230	COG0583	DNA-binding transcription factor activity
XapA_06235	COG2814	Major facilitator Superfamily
XapA_06320	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XapA_06370	COG5001	Diguanylate cyclase
XapA_06370	COG5002	protein histidine kinase activity
XapA_06375	COG1187	pseudouridine synthase activity
XapA_06400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XapA_06410	COG0475	glutathione-regulated potassium exporter activity
XapA_06415	COG5002	protein histidine kinase activity
XapA_06415	COG5000	phosphorelay sensor kinase activity
XapA_06420	COG0745	RESPONSE REGULATOR receiver
XapA_06425	COG1538	Outer membrane efflux protein
XapA_06455	COG1132	(ABC) transporter
XapA_06500	COG2155	Conserved Protein
XapA_06540	COG3118	belongs to the thioredoxin family
XapA_06550	COG0495	leucyl-tRNA aminoacylation
XapA_06565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XapA_06580	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XapA_06600	COG2968	Membrane
XapA_06605	COG0424	maF-like protein
XapA_06610	COG1530	ribonuclease E activity
XapA_06615	COG3164	Protein of unknown function
XapA_06625	COG0312	modulator of DNA gyrase
XapA_06630	COG3028	Belongs to the UPF0307 family
XapA_06635	COG0312	modulator of DNA gyrase
XapA_06650	COG3318	Belongs to the UPF0149 family
XapA_06650	COG3012	SEC-C Motif Domain Protein
XapA_06670	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XapA_06680	COG0142	geranyltranstransferase activity
XapA_06685	COG1722	exodeoxyribonuclease VII activity
XapA_06690	COG0037	tRNA processing
XapA_06700	COG1785	Belongs to the alkaline phosphatase family
XapA_06705	COG1301	dicarboxylic acid transport
XapA_06710	COG4106	trans-aconitate 2-methyltransferase activity
XapA_06720	COG0791	NLP P60 protein
XapA_06725	COG0791	NLP P60 protein
XapA_06730	COG1047	Peptidyl-prolyl cis-trans
XapA_06735	COG2311	Membrane
XapA_06740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XapA_06745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XapA_06770	COG3590	peptidase
XapA_06780	COG3590	peptidase
XapA_06840	COG3209	COG3209 Rhs family protein
XapA_06890	COG3250	beta-galactosidase activity
XapA_06895	COG3867	Arabinogalactan endo-beta-1,4-galactanase
XapA_06915	COG1960	acyl-CoA dehydrogenase activity
XapA_06920	COG1024	Enoyl-CoA hydratase
XapA_06955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XapA_06960	COG0481	GTPase activity
XapA_06975	COG0571	ribonuclease III activity
XapA_06980	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XapA_06995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XapA_07005	COG2954	triphosphatase activity
XapA_07010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XapA_07015	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
XapA_07020	COG3046	protein related to deoxyribodipyrimidine photolyase
XapA_07025	COG1472	Belongs to the glycosyl hydrolase 3 family
XapA_07035	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XapA_07045	COG1278	Cold shock
XapA_07060	COG1201	RNA secondary structure unwinding
XapA_07065	COG1793	dna ligase
XapA_07075	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XapA_07075	COG1793	dna ligase
XapA_07105	COG0183	Belongs to the thiolase family
XapA_07130	COG1451	nucleotide metabolic process
XapA_07135	COG5487	UPF0391 membrane protein
XapA_07145	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XapA_07165	COG1047	Peptidyl-prolyl cis-trans
XapA_07175	COG2824	Alkylphosphonate utilization operon protein PhnA
XapA_07190	COG2814	Major facilitator Superfamily
XapA_07220	COG0392	lysyltransferase activity
XapA_07220	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XapA_07230	COG0251	oxidation-reduction process
XapA_07235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XapA_07250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XapA_07275	COG1595	DNA-templated transcription, initiation
XapA_07295	COG2878	Part of a membrane complex involved in electron transport
XapA_07305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XapA_07305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XapA_07320	COG1131	(ABC) transporter
XapA_07325	COG0346	lactoylglutathione lyase activity
XapA_07330	COG0833	amino acid
XapA_07335	COG2040	homocysteine
XapA_07345	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XapA_07365	COG1695	Transcriptional regulator
XapA_07400	COG0825	malonyl-CoA metabolic process
XapA_07410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XapA_07415	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XapA_07420	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XapA_07425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XapA_07430	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XapA_07445	COG0750	zinc metalloprotease
XapA_07450	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XapA_07455	COG0575	Belongs to the CDS family
XapA_07460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XapA_07465	COG0233	cytoplasmic translational termination
XapA_07470	COG0528	UMP kinase activity
XapA_07480	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XapA_07485	COG0052	Belongs to the universal ribosomal protein uS2 family
XapA_07525	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XapA_07535	COG1393	Belongs to the ArsC family
XapA_07540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XapA_07545	COG0367	asparagine synthase
XapA_07555	COG4774	siderophore transport
XapA_07600	COG1566	PFAM secretion protein HlyD family protein
XapA_07605	COG2814	Major facilitator Superfamily
XapA_07630	COG3104	oligopeptide transport
XapA_07660	COG0339	signal peptide processing
XapA_07670	COG0386	Belongs to the glutathione peroxidase family
XapA_07730	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XapA_07735	COG0084	hydrolase, TatD family'
XapA_07750	COG1960	acyl-CoA dehydrogenase activity
XapA_07770	COG0367	asparagine synthase
XapA_07780	COG0305	Participates in initiation and elongation during chromosome replication
XapA_07785	COG0415	Belongs to the DNA photolyase family
XapA_07805	COG0583	DNA-binding transcription factor activity
XapA_07845	COG3706	GGDEF domain
XapA_07855	COG3706	GGDEF domain
XapA_07885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XapA_07900	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XapA_07910	COG0497	DNA recombination
XapA_07915	COG1420	regulation of RNA biosynthetic process
XapA_07920	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XapA_07925	COG0443	Heat shock 70 kDa protein
XapA_07930	COG0484	heat shock protein binding
XapA_07970	COG0583	DNA-binding transcription factor activity
XapA_07975	COG1132	(ABC) transporter
XapA_08010	COG2850	peptidyl-arginine hydroxylation
XapA_08030	COG1253	flavin adenine dinucleotide binding
XapA_08060	COG1131	(ABC) transporter
XapA_08065	COG1725	Transcriptional regulator
XapA_08075	COG0386	Belongs to the glutathione peroxidase family
XapA_08090	COG2900	Belongs to the SlyX family
XapA_08115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XapA_08140	COG1410	methionine synthase
XapA_08140	COG0646	methionine synthase
XapA_08145	COG2226	methyltransferase
XapA_08150	COG1960	acyl-CoA dehydrogenase activity
XapA_08155	COG1960	acyl-CoA dehydrogenase activity
XapA_08175	COG0557	exoribonuclease II activity
XapA_08185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XapA_08190	COG3706	GGDEF domain
XapA_08195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XapA_08205	COG0704	Plays a role in the regulation of phosphate uptake
XapA_08210	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XapA_08215	COG0581	inorganic phosphate transmembrane transporter activity
XapA_08220	COG0573	inorganic phosphate transmembrane transporter activity
XapA_08225	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XapA_08250	COG0659	secondary active sulfate transmembrane transporter activity
XapA_08255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XapA_08265	COG1024	Enoyl-CoA hydratase
XapA_08275	COG0494	nUDIX hydrolase
XapA_08325	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XapA_08350	COG2925	Exonuclease
XapA_08360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XapA_08365	COG3844	kynureninase activity
XapA_08375	COG0662	Cupin 2, conserved barrel domain protein
XapA_08380	COG0288	reversible hydration of carbon dioxide
XapA_08445	COG2808	Putative FMN-binding domain
XapA_08465	COG0017	Asparaginyl-tRNA synthetase
XapA_08475	COG0316	Belongs to the HesB IscA family
XapA_08480	COG0360	Binds together with S18 to 16S ribosomal RNA
XapA_08485	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XapA_08490	COG0359	binds to the 23S rRNA
XapA_08500	COG3115	cell septum assembly
XapA_08510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XapA_08515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XapA_08520	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XapA_08535	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XapA_08545	COG4993	Dehydrogenase
XapA_08555	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XapA_08565	COG2986	histidine ammonia-lyase
XapA_08570	COG1228	amidohydrolase
XapA_08610	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
XapA_08615	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XapA_08620	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XapA_08625	COG1605	Chorismate mutase
XapA_08625	COG0077	Prephenate dehydratase
XapA_08630	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XapA_08645	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XapA_08650	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XapA_08655	COG0583	DNA-binding transcription factor activity
XapA_08680	COG0840	transmembrane signaling receptor activity
XapA_08715	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XapA_08720	COG0784	Response regulator, receiver
XapA_08720	COG4191	Histidine kinase
XapA_08735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XapA_08745	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XapA_08755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XapA_08770	COG1595	DNA-templated transcription, initiation
XapA_08825	COG2244	polysaccharide biosynthetic process
XapA_08860	COG2264	protein methyltransferase activity
XapA_08885	COG1136	(ABC) transporter
XapA_08890	COG1132	(ABC) transporter
XapA_08895	COG0477	Major facilitator Superfamily
XapA_08900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XapA_08915	COG1253	flavin adenine dinucleotide binding
XapA_08930	COG0306	phosphate transporter
XapA_08955	COG0504	CTP synthase activity
XapA_08960	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XapA_08970	COG0148	phosphopyruvate hydratase activity
XapA_08975	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XapA_08980	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XapA_08985	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XapA_08990	COG0585	pseudouridine synthase activity
XapA_08995	COG2840	Smr protein MutS2
XapA_09000	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XapA_09005	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XapA_09010	COG1238	metal cluster binding
XapA_09025	COG1534	Rna-binding protein
XapA_09030	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XapA_09040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XapA_09045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XapA_09055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XapA_09060	COG1546	Belongs to the CinA family
XapA_09070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XapA_09075	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XapA_09085	COG2137	regulation of response to DNA damage stimulus
XapA_09090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XapA_09095	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XapA_09115	COG1741	Belongs to the pirin family
XapA_09120	COG0583	DNA-binding transcription factor activity
XapA_09145	COG0351	phosphomethylpyrimidine kinase
XapA_09160	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XapA_09165	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XapA_09180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XapA_09190	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XapA_09195	COG3734	2-keto-3-deoxy-galactonokinase
XapA_09205	COG4948	Mandelate Racemase Muconate Lactonizing
XapA_09210	COG0800	Aldolase
XapA_09250	COG1501	Belongs to the glycosyl hydrolase 31 family
XapA_09260	COG1070	Carbohydrate kinase
XapA_09265	COG2115	Belongs to the xylose isomerase family
XapA_09270	COG0477	Major facilitator Superfamily
XapA_09290	COG0860	N-Acetylmuramoyl-L-alanine amidase
XapA_09295	COG1469	GTP cyclohydrolase I activity
XapA_09315	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XapA_09320	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XapA_09325	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XapA_09330	COG0166	Belongs to the GPI family
XapA_09355	COG1472	Belongs to the glycosyl hydrolase 3 family
XapA_09370	COG4251	negative regulation of phosphorylation
XapA_09370	COG3706	GGDEF domain
XapA_09370	COG2203	Gaf domain
XapA_09370	COG5001	Diguanylate cyclase
XapA_09380	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XapA_09385	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XapA_09400	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XapA_09405	COG0671	phosphoesterase, PA-phosphatase related
XapA_09435	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XapA_09440	COG0167	dihydroorotate dehydrogenase activity
XapA_09460	COG1012	belongs to the aldehyde dehydrogenase family
XapA_09485	COG0326	Molecular chaperone. Has ATPase activity
XapA_09490	COG0742	ribosomal rna small subunit methyltransferase
XapA_09495	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XapA_09510	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XapA_09515	COG0405	Gamma-glutamyltransferase
XapA_09520	COG3291	Pkd domain containing protein
XapA_09525	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XapA_09565	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XapA_09570	COG0343	queuine tRNA-ribosyltransferase activity
XapA_09575	COG1862	Preprotein translocase
XapA_09585	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XapA_09625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XapA_09625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XapA_09630	COG1105	Belongs to the carbohydrate kinase PfkB family
XapA_09635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XapA_09635	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XapA_09640	COG1609	Transcriptional regulator
XapA_09650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XapA_09655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapA_09665	COG2902	Dehydrogenase
XapA_09700	COG1238	metal cluster binding
XapA_09720	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_09755	COG1073	alpha beta
XapA_09755	COG2226	methyltransferase
XapA_09850	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XapA_09850	COG0316	Belongs to the HesB IscA family
XapA_09855	COG2154	pterin-4-alpha-carbinolamine dehydratase
XapA_09865	COG0428	transporter
XapA_09870	COG3064	Membrane
XapA_09880	COG1530	ribonuclease E activity
XapA_09910	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XapA_09935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XapA_10015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XapA_10020	COG0322	excinuclease ABC activity
XapA_10030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XapA_10035	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XapA_10040	COG1663	tetraacyldisaccharide 4'-kinase activity
XapA_10045	COG1132	(ABC) transporter
XapA_10055	COG0811	peptide transport
XapA_10070	COG1136	(ABC) transporter
XapA_10075	COG4591	ABC-type transport system involved in lipoprotein release permease component
XapA_10085	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XapA_10105	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XapA_10130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XapA_10135	COG0837	glucose binding
XapA_10140	COG0363	glucosamine-6-phosphate deaminase activity
XapA_10145	COG0129	dihydroxy-acid dehydratase activity
XapA_10150	COG0800	Aldolase
XapA_10225	COG0784	Response regulator, receiver
XapA_10225	COG2205	protein histidine kinase activity
XapA_10230	COG2183	response to ionizing radiation
XapA_10240	COG0723	plastoquinol--plastocyanin reductase activity
XapA_10240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XapA_10255	COG3243	poly(R)-hydroxyalkanoic acid synthase
XapA_10265	COG1183	phosphatidylcholine synthase activity
XapA_10270	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_10285	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XapA_10295	COG0668	transmembrane transport
XapA_10315	COG4456	Virulence-associated protein
XapA_10380	COG3318	Belongs to the UPF0149 family
XapA_10380	COG3012	SEC-C Motif Domain Protein
XapA_10400	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XapA_10430	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XapA_10445	COG1914	H( )-stimulated, divalent metal cation uptake system
XapA_10465	COG2814	Major facilitator Superfamily
XapA_10490	COG1335	isochorismatase
XapA_10505	COG2197	response regulator
XapA_10525	COG0583	DNA-binding transcription factor activity
XapA_10530	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XapA_10535	COG3002	Belongs to the UPF0753 family
XapA_10540	COG0519	Catalyzes the synthesis of GMP from XMP
XapA_10540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XapA_10550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XapA_10560	COG0475	glutathione-regulated potassium exporter activity
XapA_10560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XapA_10570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XapA_10580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XapA_10585	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XapA_10595	COG0776	regulation of translation
XapA_10600	COG0539	negative regulation of cytoplasmic translation
XapA_10605	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XapA_10625	COG2957	Belongs to the agmatine deiminase family
XapA_10630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XapA_10655	COG0395	ABC-type sugar transport system, permease component
XapA_10660	COG1175	transmembrane transport
XapA_10690	COG2350	Protein conserved in bacteria
XapA_10695	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XapA_10700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XapA_10705	COG1187	pseudouridine synthase activity
XapA_10725	COG0436	Aminotransferase
XapA_10730	COG4133	protoheme IX ABC transporter activity
XapA_10750	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XapA_10755	COG1138	Cytochrome C-type biogenesis protein
XapA_10775	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XapA_10780	COG1278	Cold shock
XapA_10785	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XapA_10790	COG4988	ABC transporter
XapA_10800	COG1294	oxidase, subunit
XapA_10810	COG3344	reverse transcriptase
XapA_10835	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XapA_10840	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XapA_10850	COG0165	Argininosuccinate lyase
XapA_10855	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XapA_10865	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XapA_10870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XapA_10880	COG0137	argininosuccinate synthase activity
XapA_10885	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XapA_10895	COG0215	cysteine-tRNA ligase activity
XapA_10900	COG2166	iron-sulfur cluster assembly
XapA_10915	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XapA_10920	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XapA_10950	COG4302	ethanolamine ammonia-lyase activity
XapA_11020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XapA_11025	COG0402	S-adenosylhomocysteine deaminase activity
XapA_11035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XapA_11040	COG1509	lysine 2,3-aminomutase activity
XapA_11045	COG5001	Diguanylate cyclase
XapA_11045	COG3300	MHYT domain
XapA_11060	COG0483	inositol monophosphate 1-phosphatase activity
XapA_11065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XapA_11090	COG0513	Belongs to the DEAD box helicase family
XapA_11095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XapA_11100	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XapA_11110	COG0625	glutathione transferase activity
XapA_11120	COG4681	YaeQ
XapA_11125	COG2081	HI0933 family
XapA_11160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XapA_11170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XapA_11175	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_11200	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XapA_11205	COG0860	N-Acetylmuramoyl-L-alanine amidase
XapA_11210	COG0802	atpase or kinase
XapA_11215	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XapA_11215	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XapA_11220	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XapA_11225	COG1570	exodeoxyribonuclease VII activity
XapA_11240	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XapA_11280	COG0835	chemotaxis
XapA_11285	COG0840	transmembrane signaling receptor activity
XapA_11290	COG2094	Belongs to the DNA glycosylase MPG family
XapA_11295	COG1201	RNA secondary structure unwinding
XapA_11315	COG2969	positive regulation of protein catabolic process
XapA_11320	COG0625	glutathione transferase activity
XapA_11325	COG2857	Cytochrome c1
XapA_11330	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XapA_11345	COG0741	lytic transglycosylase activity
XapA_11360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XapA_11365	COG1702	phosphate starvation-inducible protein PhoH
XapA_11375	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XapA_11385	COG4535	Mg2 and Co2 transporter CorC
XapA_11400	COG1012	belongs to the aldehyde dehydrogenase family
XapA_11405	COG1177	transmembrane transport
XapA_11410	COG1176	ABC-type spermidine putrescine transport system, permease component I
XapA_11415	COG3842	ATPase activity
XapA_11435	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XapA_11450	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XapA_11455	COG0174	glutamine synthetase
XapA_11460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XapA_11470	COG2703	oxygen carrier activity
XapA_11485	COG0243	molybdopterin cofactor binding
XapA_11490	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XapA_11495	COG2223	nitrite transmembrane transporter activity
XapA_11515	COG2733	membrane
XapA_11520	COG5002	protein histidine kinase activity
XapA_11520	COG2205	protein histidine kinase activity
XapA_11520	COG0784	Response regulator, receiver
XapA_11530	COG0477	Major facilitator Superfamily
XapA_11560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapA_11580	COG4566	intracellular signal transduction
XapA_11610	COG3685	Protein conserved in bacteria
XapA_11650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XapA_11650	COG1648	precorrin-2 dehydrogenase activity
XapA_11660	COG0746	molybdenum cofactor guanylyltransferase activity
XapA_11675	COG0708	Exodeoxyribonuclease III
XapA_11715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XapA_11725	COG0303	'Molybdopterin
XapA_11730	COG1160	GTP binding
XapA_11735	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XapA_11745	COG1426	Protein conserved in bacteria
XapA_11755	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XapA_11770	COG1024	Enoyl-CoA hydratase
XapA_11770	COG1250	3-hydroxyacyl-CoA dehydrogenase
XapA_11775	COG0183	Belongs to the thiolase family
XapA_11785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XapA_11790	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XapA_11800	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XapA_11810	COG1674	ftsk spoiiie
XapA_11815	COG0492	ferredoxin-NADP+ reductase activity
XapA_11825	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XapA_11835	COG0542	response to heat
XapA_11850	COG0482	sulfurtransferase activity
XapA_11855	COG2915	High frequency lysogenization protein hflD homolog
XapA_11885	COG5002	protein histidine kinase activity
XapA_11905	COG0784	Response regulator, receiver
XapA_11905	COG0835	chemotaxis
XapA_11915	COG1558	bacterial-type flagellum-dependent cell motility
XapA_11920	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XapA_11935	COG4787	bacterial-type flagellum-dependent cell motility
XapA_11950	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XapA_11955	COG1706	bacterial-type flagellum-dependent cell motility
XapA_11960	COG3951	Flagellar rod assembly protein muramidase FlgJ
XapA_11960	COG1705	Flagellar rod assembly protein muramidase FlgJ
XapA_11970	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XapA_11975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XapA_11980	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
XapA_12010	COG2201	protein-glutamate methylesterase activity
XapA_12055	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_12060	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_12105	COG1677	Flagellar hook-basal body complex protein FliE
XapA_12155	COG3190	flagellar
XapA_12175	COG1684	flagellar biosynthetic protein fliR
XapA_12180	COG5001	Diguanylate cyclase
XapA_12180	COG3300	MHYT domain
XapA_12205	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XapA_12235	COG2198	Histidine kinase
XapA_12235	COG0784	Response regulator, receiver
XapA_12235	COG0643	Histidine kinase
XapA_12250	COG0641	radical SAM
XapA_12285	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XapA_12290	COG1360	Flagellar Motor Protein
XapA_12300	COG0835	chemotaxis
XapA_12310	COG0745	RESPONSE REGULATOR receiver
XapA_12315	COG0643	Histidine kinase
XapA_12315	COG2198	Histidine kinase
XapA_12320	COG0840	transmembrane signaling receptor activity
XapA_12335	COG0840	transmembrane signaling receptor activity
XapA_12350	COG0840	transmembrane signaling receptor activity
XapA_12355	COG0840	transmembrane signaling receptor activity
XapA_12365	COG0840	transmembrane signaling receptor activity
XapA_12370	COG0840	transmembrane signaling receptor activity
XapA_12380	COG0840	transmembrane signaling receptor activity
XapA_12385	COG0840	transmembrane signaling receptor activity
XapA_12390	COG0840	transmembrane signaling receptor activity
XapA_12395	COG0840	transmembrane signaling receptor activity
XapA_12400	COG0840	transmembrane signaling receptor activity
XapA_12410	COG0835	chemotaxis
XapA_12420	COG0840	transmembrane signaling receptor activity
XapA_12430	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
XapA_12435	COG2201	protein-glutamate methylesterase activity
XapA_12445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XapA_12475	COG0318	PFAM AMP-dependent synthetase and ligase
XapA_12510	COG1024	Enoyl-CoA hydratase
XapA_12515	COG2198	Histidine kinase
XapA_12515	COG0784	Response regulator, receiver
XapA_12515	COG2205	protein histidine kinase activity
XapA_12525	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XapA_12535	COG3279	Response regulator of the LytR AlgR family
XapA_12585	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XapA_12595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XapA_12600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XapA_12610	COG0505	Belongs to the CarA family
XapA_12615	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XapA_12620	COG2258	MOSC domain
XapA_12670	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XapA_12690	COG0277	FAD linked oxidase domain protein
XapA_12695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XapA_12705	COG0531	amino acid
XapA_12715	COG2188	Transcriptional regulator
XapA_12770	COG0531	amino acid
XapA_12775	COG0235	Class ii aldolase
XapA_12780	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XapA_12785	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XapA_12800	COG0140	phosphoribosyl-ATP diphosphatase activity
XapA_12800	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XapA_12805	COG0107	imidazoleglycerol-phosphate synthase activity
XapA_12810	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XapA_12815	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XapA_12820	COG0131	Imidazoleglycerol-phosphate dehydratase
XapA_12820	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XapA_12825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XapA_12830	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XapA_12835	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XapA_12845	COG0124	histidyl-tRNA synthetase
XapA_12850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XapA_12945	COG1649	PFAM Uncharacterised BCR, COG1649
XapA_12945	COG0726	polysaccharide deacetylase
XapA_13090	COG0531	amino acid
XapA_13105	COG0006	proline dipeptidase activity
XapA_13115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XapA_13130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XapA_13135	COG3938	Belongs to the proline racemase family
XapA_13145	COG0552	protein localization to endoplasmic reticulum
XapA_13155	COG1194	a g-specific adenine glycosylase
XapA_13160	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XapA_13165	COG0784	Response regulator, receiver
XapA_13165	COG4191	Histidine kinase
XapA_13210	COG3040	lipid binding
XapA_13225	COG1960	acyl-CoA dehydrogenase activity
XapA_13235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XapA_13255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XapA_13260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XapA_13265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XapA_13290	COG0438	transferase activity, transferring glycosyl groups
XapA_13300	COG0438	transferase activity, transferring glycosyl groups
XapA_13305	COG0438	transferase activity, transferring glycosyl groups
XapA_13355	COG0072	phenylalanine-tRNA ligase activity
XapA_13355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XapA_13360	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XapA_13375	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XapA_13380	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XapA_13430	COG2948	multi-organism process
XapA_13450	COG3505	Type IV secretory pathway VirD4
XapA_13470	COG0556	nucleotide-excision repair
XapA_13525	COG1611	Belongs to the LOG family
XapA_13540	COG2095	MarC family integral membrane protein
XapA_13550	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XapA_13585	COG1185	polyribonucleotide nucleotidyltransferase activity
XapA_13590	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XapA_13595	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XapA_13600	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XapA_13605	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XapA_13610	COG0195	Participates in both transcription termination and antitermination
XapA_13615	COG0779	Required for maturation of 30S ribosomal subunits
XapA_13625	COG1007	ATP synthesis coupled electron transport
XapA_13645	COG0839	Belongs to the complex I subunit 6 family
XapA_13650	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XapA_13655	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XapA_13665	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XapA_13670	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XapA_13675	COG0649	NAD binding
XapA_13680	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XapA_13685	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XapA_13690	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XapA_13705	COG0149	triose-phosphate isomerase activity
XapA_13710	COG0300	oxidoreductase activity
XapA_13740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XapA_13745	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XapA_13750	COG0159	tryptophan synthase activity
XapA_13760	COG0133	tryptophan synthase activity
XapA_13770	COG0135	phosphoribosylanthranilate isomerase activity
XapA_13775	COG0101	tRNA pseudouridine synthase activity
XapA_13795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XapA_13800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XapA_13805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XapA_13810	COG2890	protein-(glutamine-N5) methyltransferase activity
XapA_13820	COG0688	phosphatidylethanolamine metabolic process
XapA_13835	COG0433	COG0433 Predicted ATPase
XapA_13840	COG0494	nUDIX hydrolase
XapA_13860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XapA_13865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XapA_13880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XapA_13910	COG4695	Portal protein
XapA_13955	COG3179	chitinase
XapA_14150	COG0717	Belongs to the dCTP deaminase family
XapA_14160	COG0489	protein tyrosine kinase activity
XapA_14185	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XapA_14195	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XapA_14215	COG0534	Mate efflux family protein
XapA_14220	COG0335	large ribosomal subunit rRNA binding
XapA_14225	COG0336	Belongs to the RNA methyltransferase TrmD family
XapA_14230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XapA_14235	COG0228	four-way junction DNA binding
XapA_14240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XapA_14250	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XapA_14255	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XapA_14295	COG2205	protein histidine kinase activity
XapA_14295	COG4999	Histidine kinase
XapA_14295	COG3437	response regulator, receiver
XapA_14295	COG3850	Histidine kinase
XapA_14300	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XapA_14310	COG2205	protein histidine kinase activity
XapA_14315	COG5507	3-demethylubiquinone-9 3-methyltransferase
XapA_14325	COG4771	TonB-dependent receptor
XapA_14350	COG2172	sigma factor antagonist activity
XapA_14355	COG1366	Belongs to the anti-sigma-factor antagonist family
XapA_14360	COG1366	Belongs to the anti-sigma-factor antagonist family
XapA_14370	COG0326	Molecular chaperone. Has ATPase activity
XapA_14375	COG2207	Transcriptional regulator
XapA_14385	COG3152	Membrane
XapA_14400	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XapA_14405	COG1845	cytochrome c oxidase, subunit III
XapA_14410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XapA_14425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XapA_14430	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XapA_14435	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XapA_14440	COG0196	riboflavin kinase activity
XapA_14450	COG0268	Binds directly to 16S ribosomal RNA
XapA_14455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XapA_14460	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XapA_14465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XapA_14470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XapA_14475	COG0824	Thioesterase
XapA_14525	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XapA_14535	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
XapA_14565	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XapA_14580	COG2197	response regulator
XapA_14585	COG4585	Histidine kinase
XapA_14600	COG0850	regulation of cytokinetic process
XapA_14605	COG2894	cell division
XapA_14610	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XapA_14620	COG0642	Histidine kinase
XapA_14625	COG0745	RESPONSE REGULATOR receiver
XapA_14640	COG2194	sulfuric ester hydrolase activity
XapA_14655	COG2814	Major facilitator Superfamily
XapA_14660	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XapA_14660	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XapA_14670	COG0656	L-ascorbic acid biosynthetic process
XapA_14675	COG0753	catalase activity
XapA_14700	COG2207	Transcriptional regulator
XapA_14700	COG1917	Cupin 2, conserved barrel domain protein
XapA_14760	COG0492	ferredoxin-NADP+ reductase activity
XapA_14770	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_14775	COG3537	Alpha-1,2-mannosidase
XapA_14785	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_14790	COG3387	PFAM Glycoside hydrolase 15-related
XapA_14800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XapA_14840	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
XapA_14865	COG0732	type I restriction modification DNA specificity domain
XapA_14895	COG1309	transcriptional regulator
XapA_14900	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_14905	COG0308	aminopeptidase N
XapA_14910	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XapA_14920	COG0330	HflC and HflK could
XapA_14925	COG0330	HflC and HflK could
XapA_14945	COG0678	peroxiredoxin activity
XapA_14955	COG4953	penicillin-binding protein 1C
XapA_14975	COG2373	Large extracellular alpha-helical protein
XapA_15010	COG3609	addiction module antidote protein, CC2985 family
XapA_15030	COG3829	transcription factor binding
XapA_15055	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XapA_15060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XapA_15075	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_15090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XapA_15095	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XapA_15100	COG1399	metal-binding, possibly nucleic acid-binding protein
XapA_15105	COG0424	maF-like protein
XapA_15135	COG0714	Associated with various cellular activities
XapA_15155	COG0537	adenosine 5'-monophosphoramidase activity
XapA_15160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XapA_15165	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XapA_15185	COG0314	molybdopterin synthase activity
XapA_15190	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XapA_15195	COG0315	cyclic pyranopterin monophosphate synthase activity
XapA_15200	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XapA_15205	COG1234	tRNA 3'-trailer cleavage
XapA_15210	COG3642	lipopolysaccharide core region biosynthetic process
XapA_15215	COG0859	PFAM glycosyl transferase family 9
XapA_15230	COG0631	protein serine/threonine phosphatase activity
XapA_15235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XapA_15240	COG0328	RNA-DNA hybrid ribonuclease activity
XapA_15250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XapA_15260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XapA_15285	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XapA_15295	COG0544	peptidyl-prolyl cis-trans isomerase activity
XapA_15305	COG3852	Histidine kinase
XapA_15335	COG0473	3-isopropylmalate dehydrogenase activity
XapA_15350	COG4783	chaperone-mediated protein folding
XapA_15365	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XapA_15375	COG0438	transferase activity, transferring glycosyl groups
XapA_15380	COG0671	phosphoesterase, PA-phosphatase related
XapA_15385	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XapA_15405	COG2833	Protein of unknown function (DUF455)
XapA_15425	COG0285	dihydrofolate synthase activity
XapA_15435	COG0406	alpha-ribazole phosphatase activity
XapA_15470	COG1063	alcohol dehydrogenase
XapA_15480	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XapA_15485	COG4208	sulfate ABC transporter
XapA_15490	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XapA_15495	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XapA_15500	COG0156	8-amino-7-oxononanoate synthase activity
XapA_15535	COG1902	pentaerythritol trinitrate reductase activity
XapA_15535	COG0446	pyridine nucleotide-disulphide oxidoreductase
XapA_15555	COG0625	glutathione transferase activity
XapA_15565	COG0039	L-malate dehydrogenase activity
XapA_15570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XapA_15585	COG0154	amidase activity
XapA_15595	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XapA_15615	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XapA_15620	COG0203	ribosomal protein L17
XapA_15645	COG0201	protein transport
XapA_15650	COG0200	Binds to the 23S rRNA
XapA_15655	COG1841	ribosomal large subunit assembly
XapA_15665	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XapA_15670	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XapA_15675	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XapA_15685	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XapA_15690	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XapA_15700	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XapA_15705	COG0255	Belongs to the universal ribosomal protein uL29 family
XapA_15710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XapA_15715	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XapA_15725	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XapA_15730	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XapA_15735	COG0089	rRNA binding
XapA_15740	COG0088	Forms part of the polypeptide exit tunnel
XapA_15745	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XapA_15750	COG0051	transcription antitermination factor activity, RNA binding
XapA_15755	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XapA_15760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XapA_15765	COG0049	tRNA binding
XapA_15770	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XapA_15775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XapA_15780	COG0085	RNA polymerase activity
XapA_15785	COG0222	ribosome binding
XapA_15790	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XapA_15795	COG0081	regulation of translation
XapA_15800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XapA_15805	COG0250	Participates in transcription elongation, termination and antitermination
XapA_15820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XapA_15840	COG0012	GTP binding
XapA_15845	COG0193	aminoacyl-tRNA hydrolase activity
XapA_15850	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XapA_15855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XapA_15865	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XapA_15870	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XapA_15880	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XapA_15885	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XapA_15915	COG1254	Belongs to the acylphosphatase family
XapA_15925	COG1295	ribonuclease BN
XapA_15950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XapA_15955	COG1404	Belongs to the peptidase S8 family
XapA_15965	COG1404	Belongs to the peptidase S8 family
XapA_15975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XapA_15995	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XapA_16015	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XapA_16045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XapA_16045	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XapA_16065	COG2890	protein-(glutamine-N5) methyltransferase activity
XapA_16075	COG3634	alkyl hydroperoxide reductase activity
XapA_16080	COG0583	DNA-binding transcription factor activity
XapA_16090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XapA_16095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XapA_16105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XapA_16140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XapA_16150	COG0697	spore germination
XapA_16170	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XapA_16185	COG3386	PFAM SMP-30 Gluconolaconase
XapA_16205	COG1024	Enoyl-CoA hydratase
XapA_16215	COG0318	PFAM AMP-dependent synthetase and ligase
XapA_16220	COG0583	DNA-binding transcription factor activity
XapA_16225	COG3384	dioxygenase
XapA_16255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XapA_16260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XapA_16275	COG2096	Adenosyltransferase
XapA_16280	COG0123	including yeast histone deacetylase and acetoin utilization protein
XapA_16285	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XapA_16290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XapA_16295	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XapA_16300	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XapA_16305	COG2967	ApaG domain
XapA_16310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XapA_16330	COG0747	negative chemotaxis
XapA_16355	COG0431	NADPH-dependent FMN reductase
XapA_16360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XapA_16370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XapA_16375	COG1116	anion transmembrane transporter activity
XapA_16385	COG3829	transcription factor binding
XapA_16400	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XapA_16405	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XapA_16440	COG0588	phosphoglycerate mutase activity
XapA_16445	COG1515	deoxyribonuclease V activity
XapA_16455	COG1741	Belongs to the pirin family
XapA_16470	COG1741	Belongs to the pirin family
XapA_16475	COG1966	Carbon starvation protein
XapA_16480	COG2879	small protein
XapA_16530	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
XapA_16535	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XapA_16540	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XapA_16545	COG2080	2 iron, 2 sulfur cluster binding
XapA_16550	COG3321	synthase
XapA_16550	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_16550	COG0604	alcohol dehydrogenase
XapA_16555	COG4251	negative regulation of phosphorylation
XapA_16555	COG5001	Diguanylate cyclase
XapA_16555	COG3706	GGDEF domain
XapA_16555	COG2203	Gaf domain
XapA_16560	COG0629	single-stranded DNA binding
XapA_16565	COG0142	geranyltranstransferase activity
XapA_16580	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XapA_16595	COG0527	aspartate kinase activity
XapA_16600	COG0384	phenazine biosynthesis protein PhzF
XapA_16615	COG1764	response to oxidative stress
XapA_16620	COG0540	Belongs to the ATCase OTCase family
XapA_16625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XapA_16630	COG1678	Uncharacterized ACR, COG1678
XapA_16640	COG0519	Catalyzes the synthesis of GMP from XMP
XapA_16650	COG5297	Belongs to the glycosyl hydrolase family 6
XapA_16665	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XapA_16680	COG0739	heme binding
XapA_16700	COG0693	protein deglycase activity
XapA_16710	COG1959	2 iron, 2 sulfur cluster binding
XapA_16715	COG0719	Fe-S assembly protein
XapA_16720	COG0396	ATPase activity
XapA_16725	COG0719	Fe-S assembly protein
XapA_16730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XapA_16740	COG2146	nitrite reductase [NAD(P)H] activity
XapA_16745	COG4774	siderophore transport
XapA_16750	COG3128	pkhd-type hydroxylase
XapA_16775	COG1477	protein flavinylation
XapA_16780	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XapA_16795	COG1555	photosystem II stabilization
XapA_16810	COG3178	'Phosphotransferase
XapA_16815	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XapA_16825	COG0628	permease
XapA_16835	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XapA_16845	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XapA_16865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XapA_16870	COG0271	Belongs to the BolA IbaG family
XapA_16880	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XapA_16890	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XapA_16895	COG1137	ATPase activity
XapA_16910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XapA_16915	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XapA_16920	COG1660	Displays ATPase and GTPase activities
XapA_16930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XapA_16935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XapA_16945	COG2239	Acts as a magnesium transporter
XapA_16960	COG1294	oxidase, subunit
XapA_16965	COG1271	oxidase subunit
XapA_16985	COG1113	amino acid transport
XapA_17015	COG2197	response regulator
XapA_17020	COG0531	amino acid
XapA_17050	COG1234	tRNA 3'-trailer cleavage
XapA_17115	COG2814	Major facilitator Superfamily
XapA_17125	COG0754	glutathionylspermidine amidase activity
XapA_17150	COG1842	Phage shock protein A
XapA_17160	COG0259	pyridoxamine-phosphate oxidase activity
XapA_17165	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XapA_17170	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XapA_17180	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XapA_17185	COG0477	Major facilitator Superfamily
XapA_17205	COG2205	protein histidine kinase activity
XapA_17205	COG2198	Histidine kinase
XapA_17205	COG0784	Response regulator, receiver
XapA_17210	COG2353	YceI-like domain
XapA_17230	COG1760	l-serine dehydratase
XapA_17245	COG0460	homoserine dehydrogenase
XapA_17245	COG0527	aspartate kinase activity
XapA_17250	COG0626	cystathionine gamma-synthase activity
XapA_17255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XapA_17260	COG0739	heme binding
XapA_17265	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XapA_17270	COG1272	protein, Hemolysin III
XapA_17275	COG2982	Protein involved in outer membrane biogenesis
XapA_17280	COG0517	IMP dehydrogenase activity
XapA_17280	COG0516	GMP reductase activity
XapA_17285	COG0463	Glycosyl transferase, family 2
XapA_17290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XapA_17295	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XapA_17305	COG4771	TonB-dependent receptor
XapA_17320	COG1309	transcriptional regulator
XapA_17330	COG1960	acyl-CoA dehydrogenase activity
XapA_17360	COG0509	glycine decarboxylation via glycine cleavage system
XapA_17365	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XapA_17385	COG1742	UPF0060 membrane protein
XapA_17390	COG3956	TIGRFAM MazG family protein
XapA_17400	COG0494	nUDIX hydrolase
XapA_17410	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XapA_17415	COG0837	glucose binding
XapA_17430	COG3858	chitin binding
XapA_17430	COG1388	LysM domain
XapA_17445	COG1472	Belongs to the glycosyl hydrolase 3 family
XapA_17480	COG3537	Alpha-1,2-mannosidase
XapA_17520	COG3142	Participates in the control of copper homeostasis
XapA_17525	COG1446	asparaginase
XapA_17555	COG0784	Response regulator, receiver
XapA_17555	COG0643	Histidine kinase
XapA_17555	COG2198	Histidine kinase
XapA_17560	COG0840	transmembrane signaling receptor activity
XapA_17565	COG0835	chemotaxis
XapA_17580	COG0189	ligase activity
XapA_17590	COG1397	ADP-ribosylglycohydrolase
XapA_17600	COG1199	ATP-dependent helicase activity
XapA_17610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XapA_17615	COG1215	transferase activity, transferring glycosyl groups
XapA_17630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XapA_17640	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
XapA_17645	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
XapA_17650	COG0535	radical SAM domain protein
XapA_17655	COG0535	radical SAM domain protein
XapA_17680	COG1643	Atp-dependent helicase
XapA_17685	COG0783	Belongs to the Dps family
XapA_17695	COG0514	ATP-dependent DNA helicase (RecQ)
XapA_17730	COG0840	transmembrane signaling receptor activity
XapA_17750	COG3920	Histidine kinase
XapA_17755	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XapA_17765	COG0602	queuosine metabolic process
XapA_17775	COG2885	chlorophyll binding
XapA_17780	COG0823	Involved in the tonB-independent uptake of proteins
XapA_17790	COG0848	biopolymer transport protein
XapA_17800	COG0824	Thioesterase
XapA_17805	COG2255	four-way junction helicase activity
XapA_17815	COG3158	transport of potassium into the cell
XapA_17820	COG0632	four-way junction helicase activity
XapA_17825	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XapA_17830	COG0217	transcriptional regulatory protein
XapA_17845	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XapA_17860	COG0477	Major facilitator Superfamily
XapA_17905	COG0488	(ABC) transporter
XapA_17945	COG4651	solute:proton antiporter activity
XapA_17945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XapA_17970	COG4772	TonB-dependent receptor
XapA_17980	COG4264	IucA IucC family
XapA_17995	COG0019	diaminopimelate decarboxylase activity
XapA_18025	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XapA_18035	COG1492	cobalamin metabolic process
XapA_18065	COG4206	TonB-dependent receptor
XapA_18070	COG0542	response to heat
XapA_18075	COG1116	anion transmembrane transporter activity
XapA_18080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XapA_18085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XapA_18090	COG0667	Aldo Keto reductase
XapA_18095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XapA_18100	COG4771	TonB-dependent receptor
XapA_18110	COG2827	Endonuclease containing a URI domain
XapA_18155	COG1877	trehalose-phosphatase activity
XapA_18160	COG3387	PFAM Glycoside hydrolase 15-related
XapA_18180	COG0840	transmembrane signaling receptor activity
XapA_18185	COG3011	Protein conserved in bacteria
XapA_18200	COG0564	pseudouridine synthase activity
XapA_18205	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XapA_18215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XapA_18215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XapA_18225	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XapA_18230	COG0045	succinate-CoA ligase (ADP-forming) activity
XapA_18275	COG1459	type II secretion system
XapA_18280	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XapA_18285	COG0237	dephospho-CoA kinase activity
XapA_18305	COG0436	Aminotransferase
XapA_18335	COG0726	polysaccharide deacetylase
XapA_18340	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XapA_18355	COG3964	amidohydrolase
XapA_18360	COG0402	S-adenosylhomocysteine deaminase activity
XapA_18395	COG1307	EDD domain protein, DegV family
XapA_18400	COG0242	peptide deformylase activity
XapA_18430	COG0457	Tetratricopeptide repeat
XapA_18435	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
XapA_18440	COG1215	transferase activity, transferring glycosyl groups
XapA_18445	COG1215	transferase activity, transferring glycosyl groups
XapA_18460	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XapA_18525	COG2188	Transcriptional regulator
XapA_18540	COG1450	Type ii and iii secretion system protein
XapA_18555	COG3166	PFAM Fimbrial assembly family protein
XapA_18560	COG3156	type II secretion system protein K
XapA_18565	COG4795	General secretion pathway protein
XapA_18570	COG2165	general secretion pathway protein
XapA_18575	COG4970	Tfp pilus assembly protein FimT
XapA_18580	COG2165	general secretion pathway protein
XapA_18585	COG1459	type II secretion system
XapA_18595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XapA_18600	COG1404	Belongs to the peptidase S8 family
XapA_18605	COG5295	Hep Hag repeat protein
XapA_18610	COG1404	Belongs to the peptidase S8 family
XapA_18615	COG5295	Hep Hag repeat protein
XapA_18620	COG0047	phosphoribosylformylglycinamidine synthase activity
XapA_18620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XapA_18630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XapA_18640	COG4974	Belongs to the 'phage' integrase family
XapA_18655	COG0795	lipopolysaccharide-transporting ATPase activity
XapA_18665	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XapA_18680	COG0525	valine-tRNA ligase activity
XapA_18700	COG0741	lytic transglycosylase activity
XapA_18720	COG1183	phosphatidylcholine synthase activity
XapA_18730	COG0442	prolyl-tRNA aminoacylation
XapA_18745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XapA_18750	COG1127	ABC transporter
XapA_18755	COG3218	ABC-type transport auxiliary lipoprotein component
XapA_18755	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XapA_18790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XapA_18795	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XapA_18795	COG0662	Cupin 2, conserved barrel domain protein
XapA_18825	COG2086	electron transfer activity
XapA_18840	COG0546	phosphoglycolate phosphatase activity
XapA_18840	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XapA_18845	COG0277	FAD linked oxidase domain protein
XapA_18860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XapA_18895	COG0438	transferase activity, transferring glycosyl groups
XapA_18895	COG1216	Glycosyl transferase, family 2
XapA_18915	COG0626	cystathionine gamma-synthase activity
XapA_18945	COG0625	glutathione transferase activity
XapA_18960	COG0513	Belongs to the DEAD box helicase family
XapA_18970	COG4206	TonB-dependent receptor
XapA_18980	COG0720	synthase
XapA_18990	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XapA_19000	COG1956	GAF domain-containing protein
XapA_19010	COG2819	hydrolase of the alpha beta superfamily
XapA_19025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XapA_19030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XapA_19045	COG0339	signal peptide processing
XapA_19060	COG2132	Multicopper oxidase
XapA_19100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XapA_19105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapA_19110	COG4591	ABC-type transport system involved in lipoprotein release permease component
XapA_19110	COG1136	(ABC) transporter
XapA_19115	COG0577	efflux transmembrane transporter activity
XapA_19120	COG0577	efflux transmembrane transporter activity
XapA_19135	COG4191	Histidine kinase
XapA_19140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XapA_19155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XapA_19160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XapA_19165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XapA_19170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XapA_19175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XapA_19180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XapA_19190	COG0356	it plays a direct role in the translocation of protons across the membrane
XapA_19210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XapA_19220	COG0508	dehydrogenase complex catalyzes the overall conversion of
XapA_19265	COG2011	ABC-type metal ion transport system permease component
XapA_19270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XapA_19275	COG0697	spore germination
XapA_19280	COG1666	GTP binding
XapA_19290	COG0784	Response regulator, receiver
XapA_19290	COG2198	Histidine kinase
XapA_19290	COG5002	protein histidine kinase activity
XapA_19315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XapA_19320	COG1187	pseudouridine synthase activity
XapA_19325	COG2813	Specifically methylates the guanine in position
XapA_19345	COG2202	Pas domain
XapA_19345	COG2205	protein histidine kinase activity
XapA_19365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XapA_19370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XapA_19435	COG0842	Transport permease protein
XapA_19445	COG0025	NhaP-type Na H and K H
XapA_19455	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XapA_19460	COG1573	uracil-dna glycosylase
XapA_19470	COG3384	dioxygenase
XapA_19490	COG0667	Aldo Keto reductase
XapA_19505	COG3590	peptidase
XapA_19525	COG0531	amino acid
XapA_19540	COG2972	Histidine kinase
XapA_19565	COG3685	Protein conserved in bacteria
XapA_19570	COG3546	catalase activity
XapA_19620	COG1271	oxidase subunit
XapA_19625	COG1294	oxidase, subunit
XapA_19645	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_19650	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XapA_19680	COG1132	(ABC) transporter
XapA_19705	COG1063	alcohol dehydrogenase
XapA_19780	COG0251	oxidation-reduction process
XapA_19795	COG0840	transmembrane signaling receptor activity
XapA_19810	COG0583	DNA-binding transcription factor activity
XapA_19815	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XapA_19890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XapA_19895	COG1490	D-aminoacyl-tRNA deacylase activity
XapA_19900	COG1560	Kdo2-lipid A biosynthetic process
XapA_19955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XapA_19955	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XapA_19960	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XapA_19965	COG0242	peptide deformylase activity
XapA_19970	COG1652	LysM domain
XapA_19975	COG0758	DNA mediated transformation
XapA_19995	COG1754	DNA topoisomerase type I activity
XapA_19995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XapA_20000	COG0009	L-threonylcarbamoyladenylate synthase
XapA_20015	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_20025	COG0616	signal peptide processing
XapA_20030	COG0534	Mate efflux family protein
XapA_20050	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XapA_20055	COG0625	glutathione transferase activity
XapA_20070	COG1252	NADH dehydrogenase
XapA_20080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XapA_20085	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XapA_20090	COG3437	response regulator, receiver
XapA_20095	COG2177	Part of the ABC transporter FtsEX involved in
XapA_20100	COG2884	Cell division ATP-binding protein ftsE
XapA_20105	COG0513	Belongs to the DEAD box helicase family
XapA_20110	COG3118	belongs to the thioredoxin family
XapA_20115	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XapA_20120	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XapA_20125	COG0583	DNA-binding transcription factor activity
XapA_20170	COG1518	maintenance of DNA repeat elements
XapA_20175	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
XapA_20185	COG1652	LysM domain
XapA_20190	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XapA_20190	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XapA_20195	COG1473	amidohydrolase
XapA_20200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapA_20205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XapA_20215	COG5383	Protein conserved in bacteria
XapA_20270	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
XapA_20275	COG3023	N-Acetylmuramoyl-L-alanine amidase
XapA_20285	COG4948	Mandelate Racemase Muconate Lactonizing
XapA_20295	COG0531	amino acid
XapA_20310	COG4682	membrane
XapA_20315	COG2133	pyrroloquinoline quinone binding
XapA_20325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XapA_20330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XapA_20340	COG1610	YqeY-like protein
XapA_20350	COG1295	ribonuclease BN
XapA_20355	COG0358	DNA primase activity
XapA_20370	COG0109	protoheme IX farnesyltransferase activity
XapA_20400	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XapA_20415	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XapA_20455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XapA_20460	COG0739	heme binding
XapA_20465	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XapA_20475	COG2211	Major facilitator Superfamily
XapA_20480	COG0708	Exodeoxyribonuclease III
XapA_20485	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XapA_20495	COG1192	Involved in chromosome partitioning
XapA_20500	COG1475	DNA binding
XapA_20520	COG0463	Glycosyl transferase, family 2
XapA_20540	COG0756	dUTP diphosphatase activity
XapA_20545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XapA_20550	COG2003	Belongs to the UPF0758 family
XapA_20555	COG0018	arginyl-trna synthetase
XapA_20570	COG4221	oxidoreductase activity
XapA_20575	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XapA_20575	COG2755	lipolytic protein G-D-S-L family
XapA_20585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XapA_20590	COG1166	arginine decarboxylase activity
XapA_20595	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XapA_20645	COG2960	long-chain fatty acid transporting porin activity
XapA_20650	COG0606	chelatase, subunit chli
XapA_20665	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XapA_20700	COG1690	Belongs to the RtcB family
XapA_20735	COG1090	epimerase
XapA_20740	COG0745	RESPONSE REGULATOR receiver
XapA_20745	COG0642	Histidine kinase
XapA_20775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XapA_20800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XapA_20805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XapA_20820	COG0753	catalase activity
XapA_20845	COG2197	response regulator
XapA_20850	COG4585	Histidine kinase
XapA_20855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapA_20860	COG1136	(ABC) transporter
XapA_20885	COG0697	spore germination
XapA_20905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XapA_20910	COG0180	Tryptophanyl-tRNA synthetase
XapA_20915	COG3237	CsbD-like
XapA_20960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XapA_21010	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XapA_21015	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XapA_21015	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XapA_21045	COG2205	protein histidine kinase activity
XapA_21050	COG0745	RESPONSE REGULATOR receiver
XapA_21060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XapA_21090	COG1199	ATP-dependent helicase activity
XapA_21105	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XapA_21170	COG0625	glutathione transferase activity
XapA_21210	COG4555	ABC transporter
XapA_21220	COG1476	TRANSCRIPTIONal
XapA_21265	COG0633	Ferredoxin
XapA_21265	COG0543	2 iron, 2 sulfur cluster binding
XapA_21270	COG1131	(ABC) transporter
XapA_21275	COG0842	Transport permease protein
XapA_21285	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XapA_21320	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XapA_21330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XapA_21345	COG0045	succinate-CoA ligase (ADP-forming) activity
XapA_21345	COG1042	CoA-binding domain protein
XapA_21345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XapA_21350	COG2239	Acts as a magnesium transporter
XapA_21370	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XapA_21375	COG3387	PFAM Glycoside hydrolase 15-related
XapA_21390	COG3100	YcgL domain-containing protein
XapA_21395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XapA_21405	COG0463	Glycosyl transferase, family 2
XapA_21415	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_21455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XapA_21470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XapA_21500	COG4946	Tricorn protease homolog
XapA_21500	COG1506	peptidase
XapA_21500	COG0823	Involved in the tonB-independent uptake of proteins
XapA_21520	COG0408	coproporphyrinogen oxidase activity
XapA_21560	COG0515	serine threonine protein kinase
XapA_21565	COG0631	protein serine/threonine phosphatase activity
XapA_21600	COG3501	Rhs element vgr protein
XapA_21760	COG0210	DNA helicase
XapA_21775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XapA_21780	COG0583	DNA-binding transcription factor activity
XapA_21785	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XapA_21800	COG2159	amidohydrolase
XapA_21830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapA_21850	COG0357	Ribosomal RNA small subunit methyltransferase G
XapA_21855	COG3540	Alkaline phosphatase
XapA_21865	COG2091	lysine biosynthetic process via aminoadipic acid
XapA_21880	COG0708	Exodeoxyribonuclease III
XapA_21885	COG1846	Transcriptional regulator
XapA_21885	COG1940	carbohydrate kinase activity
XapA_21895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XapA_21905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XapA_21910	COG3162	membrane
XapA_21920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XapA_21960	COG3507	Belongs to the glycosyl hydrolase 43 family
XapA_21980	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_21985	COG0179	Fumarylacetoacetate (FAA) hydrolase
XapA_21995	COG4948	Mandelate Racemase Muconate Lactonizing
XapA_22000	COG3254	rhamnose metabolic process
XapA_22005	COG0738	Major facilitator superfamily
XapA_22010	COG1414	Transcriptional regulator
XapA_22020	COG1971	Probably functions as a manganese efflux pump
XapA_22025	COG2205	protein histidine kinase activity
XapA_22040	COG3459	Glycosyltransferase 36 associated
XapA_22045	COG2211	Major facilitator Superfamily
XapA_22050	COG3265	gluconokinase activity
XapA_22060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XapA_22080	COG2911	Protein conserved in bacteria
XapA_22085	COG0729	surface antigen
XapA_22135	COG0752	glycyl-tRNA synthetase alpha subunit
XapA_22155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XapA_22155	COG0519	Catalyzes the synthesis of GMP from XMP
XapA_22165	COG0805	protein transport
XapA_22170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XapA_22175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XapA_22185	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XapA_22210	COG2974	May be involved in recombination
XapA_22215	COG0037	tRNA processing
XapA_22225	COG2115	Belongs to the xylose isomerase family
XapA_22245	COG4948	Mandelate Racemase Muconate Lactonizing
XapA_22255	COG1472	Belongs to the glycosyl hydrolase 3 family
XapA_22260	COG0246	Mannitol dehydrogenase
XapA_22305	COG3002	Belongs to the UPF0753 family
XapA_22360	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XapA_22410	COG3318	Belongs to the UPF0149 family
XapA_22410	COG3012	SEC-C Motif Domain Protein
XapA_22430	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XapA_22450	COG0662	Cupin 2, conserved barrel domain protein
XapA_22470	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XapA_22500	COG0714	Associated with various cellular activities
XapA_22540	COG0477	Major facilitator Superfamily
XapA_22550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XapA_22595	COG3237	CsbD-like
XapA_22655	COG0564	pseudouridine synthase activity
XapA_22695	COG1309	transcriptional regulator
XapA_22705	COG1028	Short-chain dehydrogenase reductase Sdr
XapA_22755	COG3039	Transposase
XapA_22775	COG1074	ATP-dependent DNA helicase activity
XapA_22780	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XapA_22795	COG1127	ABC transporter
XapA_22800	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XapA_22805	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XapA_22820	COG2853	Lipoprotein
XapA_22830	COG0386	Belongs to the glutathione peroxidase family
XapA_22840	COG1322	Protein conserved in bacteria
XapA_22845	COG0604	alcohol dehydrogenase
XapA_22850	COG0583	DNA-binding transcription factor activity
XapA_22865	COG0625	glutathione transferase activity
XapA_22875	COG0531	amino acid
XapA_22920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XapA_22930	COG0861	Integral membrane protein TerC family
XapA_22945	COG0584	glycerophosphoryl diester phosphodiesterase
XapA_22960	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XapA_22965	COG0726	polysaccharide deacetylase
XapA_22970	COG0706	membrane insertase activity
XapA_22975	COG0594	ribonuclease P activity
XapA_23075	COG1192	Involved in chromosome partitioning
XapA_23315	COG1192	Involved in chromosome partitioning
XapA_23430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XapA_23445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XapA_23505	COG1487	ribonuclease activity
XapA_23510	COG4691	Plasmid stability protein
XapA_23725	COG2948	multi-organism process
XapA_23730	COG3504	Conjugal transfer protein
XapA_23740	COG3704	protein secretion by the type IV secretion system