locus-tag	class	description
XapB_00005	COG0667	Aldo Keto reductase
XapB_00020	COG3590	peptidase
XapB_00040	COG0531	amino acid
XapB_00055	COG2972	Histidine kinase
XapB_00080	COG3685	Protein conserved in bacteria
XapB_00085	COG3546	catalase activity
XapB_00135	COG1271	oxidase subunit
XapB_00140	COG1294	oxidase, subunit
XapB_00160	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_00165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XapB_00195	COG1132	(ABC) transporter
XapB_00220	COG1063	alcohol dehydrogenase
XapB_00295	COG0251	oxidation-reduction process
XapB_00310	COG0840	transmembrane signaling receptor activity
XapB_00325	COG0583	DNA-binding transcription factor activity
XapB_00330	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XapB_00405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XapB_00410	COG1490	D-aminoacyl-tRNA deacylase activity
XapB_00415	COG1560	Kdo2-lipid A biosynthetic process
XapB_00470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XapB_00470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XapB_00475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XapB_00480	COG0242	peptide deformylase activity
XapB_00485	COG1652	LysM domain
XapB_00490	COG0758	DNA mediated transformation
XapB_00510	COG1754	DNA topoisomerase type I activity
XapB_00510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XapB_00515	COG0009	L-threonylcarbamoyladenylate synthase
XapB_00530	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_00545	COG0616	signal peptide processing
XapB_00550	COG0534	Mate efflux family protein
XapB_00570	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XapB_00575	COG0625	glutathione transferase activity
XapB_00590	COG1252	NADH dehydrogenase
XapB_00600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XapB_00605	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XapB_00610	COG3437	response regulator, receiver
XapB_00615	COG2177	Part of the ABC transporter FtsEX involved in
XapB_00620	COG2884	Cell division ATP-binding protein ftsE
XapB_00625	COG0513	Belongs to the DEAD box helicase family
XapB_00630	COG3118	belongs to the thioredoxin family
XapB_00635	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XapB_00640	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XapB_00645	COG0583	DNA-binding transcription factor activity
XapB_00690	COG1518	maintenance of DNA repeat elements
XapB_00695	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
XapB_00705	COG1652	LysM domain
XapB_00710	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XapB_00710	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XapB_00715	COG1473	amidohydrolase
XapB_00720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapB_00725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XapB_00735	COG5383	Protein conserved in bacteria
XapB_00790	COG3023	N-Acetylmuramoyl-L-alanine amidase
XapB_00800	COG4948	Mandelate Racemase Muconate Lactonizing
XapB_00810	COG0531	amino acid
XapB_00825	COG4682	membrane
XapB_00830	COG2133	pyrroloquinoline quinone binding
XapB_00840	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XapB_00845	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XapB_00855	COG1610	YqeY-like protein
XapB_00865	COG1295	ribonuclease BN
XapB_00870	COG0358	DNA primase activity
XapB_00885	COG0109	protoheme IX farnesyltransferase activity
XapB_00915	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XapB_00930	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XapB_00970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XapB_00975	COG0739	heme binding
XapB_00980	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XapB_00990	COG2211	Major facilitator Superfamily
XapB_00995	COG0708	Exodeoxyribonuclease III
XapB_01000	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XapB_01010	COG1192	Involved in chromosome partitioning
XapB_01015	COG1475	DNA binding
XapB_01035	COG0463	Glycosyl transferase, family 2
XapB_01055	COG0756	dUTP diphosphatase activity
XapB_01060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XapB_01065	COG2003	Belongs to the UPF0758 family
XapB_01070	COG0018	arginyl-trna synthetase
XapB_01085	COG4221	oxidoreductase activity
XapB_01090	COG2755	lipolytic protein G-D-S-L family
XapB_01090	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XapB_01100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XapB_01105	COG1166	arginine decarboxylase activity
XapB_01110	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XapB_01155	COG2960	long-chain fatty acid transporting porin activity
XapB_01160	COG0606	chelatase, subunit chli
XapB_01180	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XapB_01215	COG1690	Belongs to the RtcB family
XapB_01250	COG1090	epimerase
XapB_01255	COG0745	RESPONSE REGULATOR receiver
XapB_01260	COG0642	Histidine kinase
XapB_01290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XapB_01315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XapB_01320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XapB_01335	COG0753	catalase activity
XapB_01360	COG2197	response regulator
XapB_01365	COG4585	Histidine kinase
XapB_01370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapB_01375	COG1136	(ABC) transporter
XapB_01400	COG0697	spore germination
XapB_01420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XapB_01425	COG0180	Tryptophanyl-tRNA synthetase
XapB_01430	COG3237	CsbD-like
XapB_01475	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XapB_01525	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XapB_01530	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XapB_01530	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XapB_01560	COG2205	protein histidine kinase activity
XapB_01565	COG0745	RESPONSE REGULATOR receiver
XapB_01575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XapB_01605	COG1199	ATP-dependent helicase activity
XapB_01620	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XapB_01685	COG0625	glutathione transferase activity
XapB_01725	COG4555	ABC transporter
XapB_01735	COG1476	TRANSCRIPTIONal
XapB_01780	COG0543	2 iron, 2 sulfur cluster binding
XapB_01780	COG0633	Ferredoxin
XapB_01785	COG1131	(ABC) transporter
XapB_01790	COG0842	Transport permease protein
XapB_01800	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XapB_01835	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XapB_01845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XapB_01860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XapB_01860	COG1042	CoA-binding domain protein
XapB_01860	COG0045	succinate-CoA ligase (ADP-forming) activity
XapB_01865	COG2239	Acts as a magnesium transporter
XapB_01885	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XapB_01890	COG3387	PFAM Glycoside hydrolase 15-related
XapB_01905	COG3100	YcgL domain-containing protein
XapB_01910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XapB_01920	COG0463	Glycosyl transferase, family 2
XapB_01930	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_01970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XapB_01985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XapB_02015	COG4946	Tricorn protease homolog
XapB_02015	COG1506	peptidase
XapB_02015	COG0823	Involved in the tonB-independent uptake of proteins
XapB_02035	COG0408	coproporphyrinogen oxidase activity
XapB_02075	COG0515	serine threonine protein kinase
XapB_02080	COG0631	protein serine/threonine phosphatase activity
XapB_02115	COG3501	Rhs element vgr protein
XapB_02275	COG0210	DNA helicase
XapB_02290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XapB_02295	COG0583	DNA-binding transcription factor activity
XapB_02300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XapB_02315	COG2159	amidohydrolase
XapB_02345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapB_02365	COG0357	Ribosomal RNA small subunit methyltransferase G
XapB_02370	COG3540	Alkaline phosphatase
XapB_02380	COG2091	lysine biosynthetic process via aminoadipic acid
XapB_02395	COG0708	Exodeoxyribonuclease III
XapB_02400	COG1846	Transcriptional regulator
XapB_02400	COG1940	carbohydrate kinase activity
XapB_02410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XapB_02420	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XapB_02425	COG3162	membrane
XapB_02435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XapB_02475	COG3507	Belongs to the glycosyl hydrolase 43 family
XapB_02495	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_02500	COG0179	Fumarylacetoacetate (FAA) hydrolase
XapB_02510	COG4948	Mandelate Racemase Muconate Lactonizing
XapB_02515	COG3254	rhamnose metabolic process
XapB_02520	COG0738	Major facilitator superfamily
XapB_02525	COG1414	Transcriptional regulator
XapB_02535	COG1971	Probably functions as a manganese efflux pump
XapB_02540	COG2205	protein histidine kinase activity
XapB_02555	COG3459	Glycosyltransferase 36 associated
XapB_02560	COG2211	Major facilitator Superfamily
XapB_02565	COG3265	gluconokinase activity
XapB_02575	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XapB_02595	COG2911	Protein conserved in bacteria
XapB_02600	COG0729	surface antigen
XapB_02650	COG0752	glycyl-tRNA synthetase alpha subunit
XapB_02670	COG0519	Catalyzes the synthesis of GMP from XMP
XapB_02670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XapB_02680	COG0805	protein transport
XapB_02685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XapB_02690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XapB_02700	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XapB_02725	COG2974	May be involved in recombination
XapB_02730	COG0037	tRNA processing
XapB_02740	COG2115	Belongs to the xylose isomerase family
XapB_02760	COG4948	Mandelate Racemase Muconate Lactonizing
XapB_02770	COG1472	Belongs to the glycosyl hydrolase 3 family
XapB_02775	COG0246	Mannitol dehydrogenase
XapB_02820	COG3002	Belongs to the UPF0753 family
XapB_02875	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XapB_02945	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XapB_02965	COG0662	Cupin 2, conserved barrel domain protein
XapB_02985	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XapB_03015	COG0714	Associated with various cellular activities
XapB_03055	COG0477	Major facilitator Superfamily
XapB_03065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XapB_03110	COG3237	CsbD-like
XapB_03135	COG2249	NAD(P)H dehydrogenase (quinone) activity
XapB_03150	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_03155	COG0300	oxidoreductase activity
XapB_03175	COG1272	protein, Hemolysin III
XapB_03180	COG1111	helicase
XapB_03180	COG1205	dead DEAH box helicase
XapB_03280	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XapB_03310	COG1132	(ABC) transporter
XapB_03360	COG0297	glycogen (starch) synthase activity
XapB_03360	COG0438	transferase activity, transferring glycosyl groups
XapB_03390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
XapB_03440	COG0069	glutamate synthase activity
XapB_03440	COG0067	glutamate synthase
XapB_03440	COG0070	glutamate synthase
XapB_03445	COG0493	'glutamate synthase
XapB_03450	COG1064	alcohol dehydrogenase
XapB_03460	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XapB_03470	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XapB_03480	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XapB_03490	COG2234	aminopeptidase activity
XapB_03500	COG4942	peptidase
XapB_03505	COG0793	Belongs to the peptidase S41A family
XapB_03560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XapB_03570	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XapB_03600	COG0501	Belongs to the peptidase M48B family
XapB_03610	COG0187	DNA topoisomerase II activity
XapB_03615	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XapB_03625	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XapB_03635	COG0594	ribonuclease P activity
XapB_03640	COG0706	membrane insertase activity
XapB_03645	COG0726	polysaccharide deacetylase
XapB_03650	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XapB_03665	COG0584	glycerophosphoryl diester phosphodiesterase
XapB_03680	COG0861	Integral membrane protein TerC family
XapB_03690	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XapB_03735	COG0531	amino acid
XapB_03745	COG0625	glutathione transferase activity
XapB_03760	COG0583	DNA-binding transcription factor activity
XapB_03765	COG0604	alcohol dehydrogenase
XapB_03770	COG1322	Protein conserved in bacteria
XapB_03780	COG0386	Belongs to the glutathione peroxidase family
XapB_03790	COG2853	Lipoprotein
XapB_03805	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XapB_03810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XapB_03815	COG1127	ABC transporter
XapB_03830	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XapB_03835	COG1074	ATP-dependent DNA helicase activity
XapB_03855	COG3039	Transposase
XapB_03905	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_03915	COG1309	transcriptional regulator
XapB_03955	COG0564	pseudouridine synthase activity
XapB_04000	COG1487	ribonuclease activity
XapB_04005	COG4691	Plasmid stability protein
XapB_04025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XapB_04035	COG0477	Major facilitator Superfamily
XapB_04040	COG1289	transmembrane transporter activity
XapB_04050	COG1566	PFAM secretion protein HlyD family protein
XapB_04065	COG0302	gtp cyclohydrolase
XapB_04085	COG0730	response to heat
XapB_04090	COG3012	SEC-C Motif Domain Protein
XapB_04100	COG0676	glucose-6-phosphate 1-epimerase activity
XapB_04125	COG3135	benzoate transporter
XapB_04155	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XapB_04175	COG0210	DNA helicase
XapB_04190	COG3132	Protein of unknown function, DUF480
XapB_04200	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
XapB_04205	COG0284	orotidine-5'-phosphate decarboxylase activity
XapB_04240	COG2937	Belongs to the GPAT DAPAT family
XapB_04275	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XapB_04360	COG0366	Alpha amylase catalytic
XapB_04365	COG0366	Alpha amylase catalytic
XapB_04370	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XapB_04390	COG0657	acetylesterase activity
XapB_04390	COG2755	lipolytic protein G-D-S-L family
XapB_04400	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XapB_04415	COG3507	Belongs to the glycosyl hydrolase 43 family
XapB_04430	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
XapB_04435	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_04445	COG2755	lipolytic protein G-D-S-L family
XapB_04460	COG3186	Phenylalanine-4-hydroxylase
XapB_04465	COG1522	sequence-specific DNA binding
XapB_04475	COG1752	Esterase of the alpha-beta hydrolase superfamily
XapB_04485	COG1119	ATPase activity
XapB_04500	COG1125	glycine betaine transport
XapB_04515	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XapB_04570	COG0489	protein tyrosine kinase activity
XapB_04575	COG2062	phosphohistidine phosphatase, SixA
XapB_04585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XapB_04635	COG1968	undecaprenyl-diphosphatase activity
XapB_04645	COG0174	glutamine synthetase
XapB_04650	COG0347	Belongs to the P(II) protein family
XapB_04655	COG0004	ammonium transporteR
XapB_04660	COG3852	Histidine kinase
XapB_04665	COG2204	response regulator
XapB_04670	COG2032	superoxide dismutase activity
XapB_04675	COG2032	superoxide dismutase activity
XapB_04690	COG0183	Belongs to the thiolase family
XapB_04725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XapB_04730	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XapB_04735	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XapB_04790	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XapB_04795	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XapB_04800	COG4786	Flagellar basal body rod
XapB_04805	COG4786	Flagellar basal body rod
XapB_04820	COG1706	bacterial-type flagellum-dependent cell motility
XapB_04835	COG1677	Flagellar hook-basal body complex protein FliE
XapB_04840	COG1766	The M ring may be actively involved in energy transduction
XapB_04855	COG1157	protein secretion by the type III secretion system
XapB_04880	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XapB_04915	COG0028	Belongs to the TPP enzyme family
XapB_04920	COG2205	protein histidine kinase activity
XapB_04945	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XapB_04960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XapB_04970	COG0596	Alpha beta hydrolase
XapB_04975	COG0727	PFAM Uncharacterised protein family (UPF0153)
XapB_04980	COG0318	PFAM AMP-dependent synthetase and ligase
XapB_04985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XapB_05000	COG1181	Belongs to the D-alanine--D-alanine ligase family
XapB_05010	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XapB_05020	COG0564	pseudouridine synthase activity
XapB_05040	COG1446	asparaginase
XapB_05045	COG0339	signal peptide processing
XapB_05075	COG0475	glutathione-regulated potassium exporter activity
XapB_05080	COG0583	DNA-binding transcription factor activity
XapB_05085	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XapB_05090	COG2224	Isocitrate lyase
XapB_05095	COG3706	GGDEF domain
XapB_05130	COG4770	biotin carboxylase activity
XapB_05135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XapB_05140	COG1960	acyl-CoA dehydrogenase activity
XapB_05145	COG1309	transcriptional regulator
XapB_05200	COG0523	cobalamin synthesis protein
XapB_05220	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XapB_05225	COG1846	Transcriptional regulator
XapB_05230	COG1764	response to oxidative stress
XapB_05260	COG2130	NADP-dependent
XapB_05275	COG1187	pseudouridine synthase activity
XapB_05290	COG1643	Atp-dependent helicase
XapB_05295	COG4807	Protein conserved in bacteria
XapB_05300	COG2351	hydroxyisourate hydrolase activity
XapB_05305	COG2072	flavoprotein involved in K transport
XapB_05325	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XapB_05360	COG1957	nucleoside hydrolase
XapB_05370	COG2252	PERMEase
XapB_05395	COG0084	hydrolase, TatD family'
XapB_05415	COG0583	DNA-binding transcription factor activity
XapB_05420	COG2814	Major facilitator Superfamily
XapB_05435	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XapB_05440	COG1902	pentaerythritol trinitrate reductase activity
XapB_05460	COG0745	RESPONSE REGULATOR receiver
XapB_05465	COG2205	protein histidine kinase activity
XapB_05470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapB_05495	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XapB_05500	COG0583	DNA-binding transcription factor activity
XapB_05535	COG0702	epimerase
XapB_05540	COG1733	regulation of RNA biosynthetic process
XapB_05585	COG0129	dihydroxy-acid dehydratase activity
XapB_05600	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XapB_05660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XapB_05665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XapB_05695	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XapB_05700	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XapB_05710	COG3485	protocatechuate 3,4-dioxygenase
XapB_05725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XapB_05730	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XapB_05740	COG1414	Transcriptional regulator
XapB_05760	COG0445	tRNA wobble uridine modification
XapB_05800	COG2267	carboxylic ester hydrolase activity
XapB_05810	COG0156	8-amino-7-oxononanoate synthase activity
XapB_05815	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XapB_05820	COG1040	competence protein
XapB_05825	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XapB_05915	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XapB_05985	COG1511	domain protein
XapB_05985	COG3264	Mechanosensitive ion channel
XapB_05990	COG1368	sulfuric ester hydrolase activity
XapB_06000	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XapB_06005	COG2354	Protein conserved in bacteria
XapB_06015	COG0297	glycogen (starch) synthase activity
XapB_06020	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XapB_06025	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XapB_06050	COG0702	epimerase
XapB_06055	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_06090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XapB_06095	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_06110	COG0513	Belongs to the DEAD box helicase family
XapB_06130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
XapB_06145	COG3483	tryptophan 2,3-dioxygenase activity
XapB_06150	COG3104	oligopeptide transport
XapB_06175	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
XapB_06195	COG1320	monovalent cation:proton antiporter activity
XapB_06200	COG2212	antiporter activity
XapB_06210	COG0651	ATP synthesis coupled electron transport
XapB_06215	COG1006	Multisubunit Na H antiporter MnhC subunit
XapB_06220	COG2111	Na H antiporter
XapB_06220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XapB_06245	COG3179	chitinase
XapB_06265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XapB_06270	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XapB_06285	COG0456	acetyltransferase
XapB_06290	COG1597	lipid kinase activity
XapB_06315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XapB_06320	COG0134	indole-3-glycerol-phosphate synthase activity
XapB_06330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XapB_06335	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XapB_06345	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XapB_06355	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XapB_06370	COG1051	belongs to the nudix hydrolase family
XapB_06410	COG0316	Belongs to the HesB IscA family
XapB_06430	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XapB_06450	COG2814	Major facilitator Superfamily
XapB_06460	COG2814	Major facilitator Superfamily
XapB_06465	COG1289	transmembrane transporter activity
XapB_06475	COG0151	Belongs to the GarS family
XapB_06485	COG0138	bifunctional purine biosynthesis protein purh
XapB_06490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XapB_06495	COG2267	carboxylic ester hydrolase activity
XapB_06500	COG2453	phosphatase
XapB_06500	COG0671	phosphoesterase, PA-phosphatase related
XapB_06525	COG4589	Belongs to the CDS family
XapB_06530	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XapB_06555	COG2264	protein methyltransferase activity
XapB_06575	COG0439	Biotin carboxylase
XapB_06585	COG0511	ligase activity, forming carbon-carbon bonds
XapB_06590	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XapB_06600	COG1324	tolerance protein
XapB_06630	COG0300	oxidoreductase activity
XapB_06640	COG2356	endonuclease I
XapB_06650	COG0459	protein refolding
XapB_06665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XapB_06680	COG3386	PFAM SMP-30 Gluconolaconase
XapB_06690	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XapB_06695	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XapB_06715	COG0778	Nitroreductase
XapB_06720	COG2353	YceI-like domain
XapB_06750	COG3052	prosthetic group binding
XapB_06785	COG1802	Transcriptional regulator
XapB_06860	COG4221	oxidoreductase activity
XapB_06875	COG4221	oxidoreductase activity
XapB_06890	COG0435	Glutathione S-transferase
XapB_06915	COG2409	Drug exporters of the RND superfamily
XapB_06925	COG1506	peptidase
XapB_06925	COG0823	Involved in the tonB-independent uptake of proteins
XapB_06945	COG3706	GGDEF domain
XapB_06970	COG0697	spore germination
XapB_06985	COG1113	amino acid transport
XapB_07005	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
XapB_07055	COG5001	Diguanylate cyclase
XapB_07065	COG0840	transmembrane signaling receptor activity
XapB_07070	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XapB_07070	COG5297	Belongs to the glycosyl hydrolase family 6
XapB_07075	COG0659	secondary active sulfate transmembrane transporter activity
XapB_07085	COG3706	GGDEF domain
XapB_07105	COG2943	transferase activity, transferring hexosyl groups
XapB_07115	COG3275	phosphorelay sensor kinase activity
XapB_07125	COG0181	hydroxymethylbilane synthase activity
XapB_07165	COG1505	serine-type exopeptidase activity
XapB_07185	COG2832	Protein of unknown function (DUF454)
XapB_07195	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XapB_07205	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XapB_07210	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XapB_07215	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XapB_07240	COG2226	methyltransferase
XapB_07245	COG2199	diguanylate cyclase activity
XapB_07250	COG0308	aminopeptidase N
XapB_07285	COG1162	GTPase activity
XapB_07310	COG2211	Major facilitator Superfamily
XapB_07315	COG1609	Transcriptional regulator
XapB_07320	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_07325	COG2851	Citrate transporter
XapB_07345	COG0642	Histidine kinase
XapB_07360	COG2197	response regulator
XapB_07380	COG0667	Aldo Keto reductase
XapB_07390	COG0583	DNA-binding transcription factor activity
XapB_07420	COG1301	dicarboxylic acid transport
XapB_07425	COG0281	malic enzyme
XapB_07425	COG0280	phosphate acetyltransferase
XapB_07450	COG1560	Kdo2-lipid A biosynthetic process
XapB_07455	COG1519	Transferase
XapB_07460	COG1538	Outer membrane efflux protein
XapB_07465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XapB_07485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XapB_07490	COG0066	3-isopropylmalate dehydratase activity
XapB_07495	COG0473	3-isopropylmalate dehydrogenase activity
XapB_07500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XapB_07520	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XapB_07530	COG0840	transmembrane signaling receptor activity
XapB_07545	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XapB_07550	COG3710	Transcriptional regulator
XapB_07580	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XapB_07590	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XapB_07615	COG0563	adenylate kinase activity
XapB_07620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XapB_07630	COG3781	membrane
XapB_07635	COG0671	phosphoesterase, PA-phosphatase related
XapB_07645	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_07655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XapB_07660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XapB_07690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XapB_07705	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XapB_07720	COG0352	thiamine-phosphate diphosphorylase activity
XapB_07725	COG1773	rubredoxin
XapB_07730	COG2912	Transglutaminase-like superfamily
XapB_07740	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XapB_07750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XapB_07770	COG3079	Belongs to the UPF0149 family
XapB_07775	COG0006	proline dipeptidase activity
XapB_07785	COG0006	proline dipeptidase activity
XapB_07805	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XapB_07815	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XapB_07820	COG1561	YicC-like family, N-terminal region
XapB_07825	COG0194	GDP metabolic process
XapB_07835	COG1070	Carbohydrate kinase
XapB_07840	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_07860	COG3659	wide pore channel activity
XapB_07875	COG2390	Transcriptional regulator
XapB_07880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XapB_07885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XapB_07895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XapB_07925	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XapB_07955	COG0714	Associated with various cellular activities
XapB_07975	COG2304	oxidoreductase activity
XapB_07990	COG1301	dicarboxylic acid transport
XapB_07995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XapB_08000	COG0596	Alpha beta hydrolase
XapB_08005	COG4773	Receptor
XapB_08015	COG0739	heme binding
XapB_08025	COG1376	ErfK ybiS ycfS ynhG family protein
XapB_08060	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XapB_08065	COG4149	molybdate abc transporter
XapB_08070	COG0725	ABC transporter, periplasmic molybdate-binding protein
XapB_08075	COG3453	Protein conserved in bacteria
XapB_08075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XapB_08085	COG3047	cAMP biosynthetic process
XapB_08090	COG3047	cAMP biosynthetic process
XapB_08105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XapB_08130	COG0126	phosphoglycerate kinase activity
XapB_08140	COG0469	pyruvate kinase activity
XapB_08145	COG3588	fructose-bisphosphate aldolase
XapB_08150	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
XapB_08165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XapB_08165	COG1648	precorrin-2 dehydrogenase activity
XapB_08185	COG2205	protein histidine kinase activity
XapB_08185	COG2198	Histidine kinase
XapB_08185	COG0784	Response regulator, receiver
XapB_08205	COG0175	sulfate reduction
XapB_08210	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XapB_08215	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XapB_08220	COG0175	sulfate reduction
XapB_08225	COG2895	sulfate adenylyltransferase (ATP) activity
XapB_08225	COG0529	Catalyzes the synthesis of activated sulfate
XapB_08230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapB_08235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XapB_08285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XapB_08300	COG4948	Mandelate Racemase Muconate Lactonizing
XapB_08305	COG3250	beta-galactosidase activity
XapB_08315	COG1609	Transcriptional regulator
XapB_08325	COG1970	mechanosensitive ion channel activity
XapB_08350	COG0471	metal ion transport
XapB_08350	COG3273	potassium ion transport
XapB_08355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XapB_08365	COG2022	thiamine diphosphate biosynthetic process
XapB_08410	COG0189	ligase activity
XapB_08420	COG0745	RESPONSE REGULATOR receiver
XapB_08425	COG5002	protein histidine kinase activity
XapB_08520	COG2010	Cytochrome c
XapB_08540	COG3284	Transcriptional regulator
XapB_08545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XapB_08550	COG1077	Cell shape determining protein MreB Mrl
XapB_08555	COG1792	Involved in formation and maintenance of cell shape
XapB_08570	COG0772	Belongs to the SEDS family
XapB_08580	COG2951	lytic endotransglycosylase activity
XapB_08585	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XapB_08595	COG1686	Belongs to the peptidase S11 family
XapB_08605	COG2921	Belongs to the UPF0250 family
XapB_08610	COG0321	lipoyl(octanoyl) transferase activity
XapB_08615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XapB_08630	COG0583	DNA-binding transcription factor activity
XapB_08640	COG1056	cytidyltransferase-related domain
XapB_08640	COG1051	belongs to the nudix hydrolase family
XapB_08675	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XapB_08680	COG0673	inositol 2-dehydrogenase activity
XapB_08685	COG2823	Periplasmic or secreted lipoprotein
XapB_08690	COG4251	negative regulation of phosphorylation
XapB_08695	COG0784	Response regulator, receiver
XapB_08700	COG4191	Histidine kinase
XapB_08705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XapB_08765	COG1459	type II secretion system
XapB_08785	COG4795	General secretion pathway protein
XapB_08815	COG3250	beta-galactosidase activity
XapB_08830	COG2188	Transcriptional regulator
XapB_08840	COG1609	Transcriptional regulator
XapB_08845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XapB_08850	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XapB_08860	COG0617	tRNA 3'-terminal CCA addition
XapB_08865	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XapB_08870	COG1012	belongs to the aldehyde dehydrogenase family
XapB_08875	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XapB_08905	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XapB_08910	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XapB_08930	COG2205	protein histidine kinase activity
XapB_08935	COG0745	RESPONSE REGULATOR receiver
XapB_08960	COG3791	Glutathione-dependent formaldehyde-activating
XapB_08975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XapB_08985	COG0697	spore germination
XapB_08995	COG0488	(ABC) transporter
XapB_09005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XapB_09010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XapB_09020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XapB_09020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XapB_09040	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XapB_09045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XapB_09050	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XapB_09075	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XapB_09080	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XapB_09085	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
XapB_09090	COG2205	protein histidine kinase activity
XapB_09095	COG0745	RESPONSE REGULATOR receiver
XapB_09125	COG0277	FAD linked oxidase domain protein
XapB_09130	COG1988	membrane-bound metal-dependent
XapB_09135	COG0792	nuclease activity
XapB_09175	COG0275	rRNA processing
XapB_09180	COG3116	cell division
XapB_09190	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XapB_09195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XapB_09200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XapB_09210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XapB_09215	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XapB_09220	COG1181	Belongs to the D-alanine--D-alanine ligase family
XapB_09225	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XapB_09240	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XapB_09255	COG0653	protein targeting
XapB_09260	COG0494	nUDIX hydrolase
XapB_09270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XapB_09285	COG0604	alcohol dehydrogenase
XapB_09285	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_09285	COG3321	synthase
XapB_09315	COG0366	Alpha amylase catalytic
XapB_09350	COG2226	methyltransferase
XapB_09355	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XapB_09365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XapB_09415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XapB_09425	COG4106	trans-aconitate 2-methyltransferase activity
XapB_09430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XapB_09440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XapB_09445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XapB_09455	COG0667	Aldo Keto reductase
XapB_09465	COG4771	TonB-dependent receptor
XapB_09485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XapB_09490	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XapB_09500	COG2175	clavaminate synthase activity
XapB_09510	COG4181	ATPase activity
XapB_09525	COG0642	Histidine kinase
XapB_09545	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XapB_09560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XapB_09565	COG2201	protein-glutamate methylesterase activity
XapB_09570	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XapB_09575	COG2202	Pas domain
XapB_09575	COG2200	EAL domain
XapB_09575	COG2199	diguanylate cyclase activity
XapB_09580	COG0835	chemotaxis
XapB_09585	COG0840	transmembrane signaling receptor activity
XapB_09590	COG2198	Histidine kinase
XapB_09590	COG0643	Histidine kinase
XapB_09600	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XapB_09610	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XapB_09620	COG2205	protein histidine kinase activity
XapB_09625	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XapB_09635	COG4452	Inner membrane protein CreD
XapB_09660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XapB_09665	COG0735	belongs to the Fur family
XapB_09680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XapB_09700	COG2207	Transcriptional regulator
XapB_09715	COG2814	Major facilitator Superfamily
XapB_09850	COG5002	protein histidine kinase activity
XapB_09850	COG5001	Diguanylate cyclase
XapB_09855	COG1187	pseudouridine synthase activity
XapB_09880	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XapB_09890	COG0475	glutathione-regulated potassium exporter activity
XapB_09895	COG5002	protein histidine kinase activity
XapB_09895	COG5000	phosphorelay sensor kinase activity
XapB_09900	COG0745	RESPONSE REGULATOR receiver
XapB_09905	COG1538	Outer membrane efflux protein
XapB_09935	COG1132	(ABC) transporter
XapB_09980	COG2155	Conserved Protein
XapB_10020	COG3118	belongs to the thioredoxin family
XapB_10025	COG0495	leucyl-tRNA aminoacylation
XapB_10040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XapB_10055	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XapB_10075	COG2968	Membrane
XapB_10080	COG0424	maF-like protein
XapB_10085	COG1530	ribonuclease E activity
XapB_10090	COG3164	Protein of unknown function
XapB_10100	COG0312	modulator of DNA gyrase
XapB_10105	COG3028	Belongs to the UPF0307 family
XapB_10110	COG0312	modulator of DNA gyrase
XapB_10125	COG3012	SEC-C Motif Domain Protein
XapB_10125	COG3318	Belongs to the UPF0149 family
XapB_10155	COG0142	geranyltranstransferase activity
XapB_10160	COG1722	exodeoxyribonuclease VII activity
XapB_10165	COG0037	tRNA processing
XapB_10175	COG1785	Belongs to the alkaline phosphatase family
XapB_10180	COG1301	dicarboxylic acid transport
XapB_10185	COG4106	trans-aconitate 2-methyltransferase activity
XapB_10195	COG0791	NLP P60 protein
XapB_10200	COG0791	NLP P60 protein
XapB_10205	COG1047	Peptidyl-prolyl cis-trans
XapB_10210	COG2311	Membrane
XapB_10215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XapB_10220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XapB_10245	COG3590	peptidase
XapB_10255	COG3590	peptidase
XapB_10315	COG3209	COG3209 Rhs family protein
XapB_10360	COG3250	beta-galactosidase activity
XapB_10365	COG3867	Arabinogalactan endo-beta-1,4-galactanase
XapB_10385	COG1960	acyl-CoA dehydrogenase activity
XapB_10390	COG1024	Enoyl-CoA hydratase
XapB_10425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XapB_10430	COG0481	GTPase activity
XapB_10445	COG0571	ribonuclease III activity
XapB_10450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XapB_10465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XapB_10475	COG2954	triphosphatase activity
XapB_10480	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XapB_10485	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
XapB_10490	COG3046	protein related to deoxyribodipyrimidine photolyase
XapB_10495	COG1472	Belongs to the glycosyl hydrolase 3 family
XapB_10505	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XapB_10515	COG1278	Cold shock
XapB_10530	COG1201	RNA secondary structure unwinding
XapB_10535	COG1793	dna ligase
XapB_10545	COG1793	dna ligase
XapB_10545	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XapB_10575	COG0183	Belongs to the thiolase family
XapB_10600	COG1451	nucleotide metabolic process
XapB_10605	COG5487	UPF0391 membrane protein
XapB_10615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XapB_10635	COG1047	Peptidyl-prolyl cis-trans
XapB_10645	COG2824	Alkylphosphonate utilization operon protein PhnA
XapB_10660	COG2814	Major facilitator Superfamily
XapB_10690	COG0392	lysyltransferase activity
XapB_10690	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XapB_10700	COG0251	oxidation-reduction process
XapB_10705	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XapB_10720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XapB_10745	COG1595	DNA-templated transcription, initiation
XapB_10765	COG2878	Part of a membrane complex involved in electron transport
XapB_10775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XapB_10775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XapB_10790	COG1131	(ABC) transporter
XapB_10795	COG0346	lactoylglutathione lyase activity
XapB_10800	COG0833	amino acid
XapB_10805	COG2040	homocysteine
XapB_10815	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XapB_10835	COG1695	Transcriptional regulator
XapB_10870	COG0825	malonyl-CoA metabolic process
XapB_10880	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XapB_10885	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XapB_10890	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XapB_10895	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XapB_10900	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XapB_10915	COG0750	zinc metalloprotease
XapB_10920	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XapB_10925	COG0575	Belongs to the CDS family
XapB_10930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XapB_10935	COG0233	cytoplasmic translational termination
XapB_10940	COG0528	UMP kinase activity
XapB_10950	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XapB_10955	COG0052	Belongs to the universal ribosomal protein uS2 family
XapB_10995	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XapB_11005	COG1393	Belongs to the ArsC family
XapB_11010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XapB_11015	COG0367	asparagine synthase
XapB_11025	COG4774	siderophore transport
XapB_11070	COG1566	PFAM secretion protein HlyD family protein
XapB_11075	COG2814	Major facilitator Superfamily
XapB_11100	COG3104	oligopeptide transport
XapB_11130	COG0339	signal peptide processing
XapB_11140	COG0386	Belongs to the glutathione peroxidase family
XapB_11200	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XapB_11205	COG0084	hydrolase, TatD family'
XapB_11220	COG1960	acyl-CoA dehydrogenase activity
XapB_11240	COG0367	asparagine synthase
XapB_11250	COG0305	Participates in initiation and elongation during chromosome replication
XapB_11255	COG0415	Belongs to the DNA photolyase family
XapB_11275	COG0583	DNA-binding transcription factor activity
XapB_11315	COG3706	GGDEF domain
XapB_11325	COG3706	GGDEF domain
XapB_11355	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XapB_11370	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XapB_11380	COG0497	DNA recombination
XapB_11385	COG1420	regulation of RNA biosynthetic process
XapB_11390	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XapB_11395	COG0443	Heat shock 70 kDa protein
XapB_11400	COG0484	heat shock protein binding
XapB_11440	COG0583	DNA-binding transcription factor activity
XapB_11445	COG1132	(ABC) transporter
XapB_11480	COG2850	peptidyl-arginine hydroxylation
XapB_11500	COG1253	flavin adenine dinucleotide binding
XapB_11530	COG1131	(ABC) transporter
XapB_11535	COG1725	Transcriptional regulator
XapB_11545	COG0386	Belongs to the glutathione peroxidase family
XapB_11560	COG2900	Belongs to the SlyX family
XapB_11585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XapB_11610	COG1410	methionine synthase
XapB_11610	COG0646	methionine synthase
XapB_11615	COG2226	methyltransferase
XapB_11620	COG1960	acyl-CoA dehydrogenase activity
XapB_11625	COG1960	acyl-CoA dehydrogenase activity
XapB_11645	COG0557	exoribonuclease II activity
XapB_11655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XapB_11660	COG3706	GGDEF domain
XapB_11665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XapB_11675	COG0704	Plays a role in the regulation of phosphate uptake
XapB_11680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XapB_11685	COG0581	inorganic phosphate transmembrane transporter activity
XapB_11690	COG0573	inorganic phosphate transmembrane transporter activity
XapB_11695	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XapB_11720	COG0659	secondary active sulfate transmembrane transporter activity
XapB_11725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XapB_11735	COG1024	Enoyl-CoA hydratase
XapB_11745	COG0494	nUDIX hydrolase
XapB_11795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XapB_11820	COG2925	Exonuclease
XapB_11830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XapB_11835	COG3844	kynureninase activity
XapB_11845	COG0662	Cupin 2, conserved barrel domain protein
XapB_11850	COG0288	reversible hydration of carbon dioxide
XapB_11915	COG2808	Putative FMN-binding domain
XapB_11935	COG0017	Asparaginyl-tRNA synthetase
XapB_11945	COG0316	Belongs to the HesB IscA family
XapB_11950	COG0360	Binds together with S18 to 16S ribosomal RNA
XapB_11955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XapB_11960	COG0359	binds to the 23S rRNA
XapB_11970	COG3115	cell septum assembly
XapB_11980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XapB_11985	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XapB_11990	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XapB_12005	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XapB_12015	COG4993	Dehydrogenase
XapB_12040	COG2986	histidine ammonia-lyase
XapB_12045	COG1228	amidohydrolase
XapB_12085	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
XapB_12090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XapB_12095	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XapB_12100	COG0077	Prephenate dehydratase
XapB_12100	COG1605	Chorismate mutase
XapB_12105	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XapB_12120	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XapB_12125	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XapB_12130	COG0583	DNA-binding transcription factor activity
XapB_12155	COG0840	transmembrane signaling receptor activity
XapB_12190	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XapB_12195	COG4191	Histidine kinase
XapB_12195	COG0784	Response regulator, receiver
XapB_12210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XapB_12220	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XapB_12230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XapB_12245	COG1595	DNA-templated transcription, initiation
XapB_12300	COG2244	polysaccharide biosynthetic process
XapB_12335	COG2264	protein methyltransferase activity
XapB_12360	COG1136	(ABC) transporter
XapB_12365	COG1132	(ABC) transporter
XapB_12370	COG0477	Major facilitator Superfamily
XapB_12375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XapB_12390	COG1253	flavin adenine dinucleotide binding
XapB_12405	COG0306	phosphate transporter
XapB_12430	COG0504	CTP synthase activity
XapB_12435	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XapB_12445	COG0148	phosphopyruvate hydratase activity
XapB_12450	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XapB_12455	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XapB_12460	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XapB_12465	COG0585	pseudouridine synthase activity
XapB_12470	COG2840	Smr protein MutS2
XapB_12475	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XapB_12480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XapB_12485	COG1238	metal cluster binding
XapB_12500	COG1534	Rna-binding protein
XapB_12505	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XapB_12515	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XapB_12520	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XapB_12530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XapB_12535	COG1546	Belongs to the CinA family
XapB_12545	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XapB_12550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XapB_12560	COG2137	regulation of response to DNA damage stimulus
XapB_12565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XapB_12570	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XapB_12590	COG1741	Belongs to the pirin family
XapB_12595	COG0583	DNA-binding transcription factor activity
XapB_12620	COG0351	phosphomethylpyrimidine kinase
XapB_12635	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XapB_12640	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XapB_12655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XapB_12665	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XapB_12670	COG3734	2-keto-3-deoxy-galactonokinase
XapB_12680	COG4948	Mandelate Racemase Muconate Lactonizing
XapB_12685	COG0800	Aldolase
XapB_12725	COG1501	Belongs to the glycosyl hydrolase 31 family
XapB_12735	COG1070	Carbohydrate kinase
XapB_12740	COG2115	Belongs to the xylose isomerase family
XapB_12745	COG0477	Major facilitator Superfamily
XapB_12765	COG0860	N-Acetylmuramoyl-L-alanine amidase
XapB_12770	COG1469	GTP cyclohydrolase I activity
XapB_12790	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XapB_12795	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XapB_12800	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XapB_12805	COG0166	Belongs to the GPI family
XapB_12830	COG1472	Belongs to the glycosyl hydrolase 3 family
XapB_12845	COG5001	Diguanylate cyclase
XapB_12845	COG3706	GGDEF domain
XapB_12845	COG2203	Gaf domain
XapB_12845	COG4251	negative regulation of phosphorylation
XapB_12855	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XapB_12860	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XapB_12875	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XapB_12880	COG0671	phosphoesterase, PA-phosphatase related
XapB_12910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XapB_12915	COG0167	dihydroorotate dehydrogenase activity
XapB_12935	COG1012	belongs to the aldehyde dehydrogenase family
XapB_12965	COG0326	Molecular chaperone. Has ATPase activity
XapB_12970	COG0742	ribosomal rna small subunit methyltransferase
XapB_12975	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XapB_12990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XapB_12995	COG0405	Gamma-glutamyltransferase
XapB_13000	COG3291	Pkd domain containing protein
XapB_13005	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XapB_13045	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XapB_13050	COG0343	queuine tRNA-ribosyltransferase activity
XapB_13055	COG1862	Preprotein translocase
XapB_13065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XapB_13110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XapB_13110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XapB_13115	COG1105	Belongs to the carbohydrate kinase PfkB family
XapB_13120	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XapB_13120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XapB_13125	COG1609	Transcriptional regulator
XapB_13140	COG0477	Major facilitator Superfamily
XapB_13150	COG5002	protein histidine kinase activity
XapB_13150	COG0784	Response regulator, receiver
XapB_13150	COG2205	protein histidine kinase activity
XapB_13155	COG2733	membrane
XapB_13180	COG2223	nitrite transmembrane transporter activity
XapB_13185	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XapB_13190	COG0243	molybdopterin cofactor binding
XapB_13205	COG2703	oxygen carrier activity
XapB_13215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XapB_13220	COG0174	glutamine synthetase
XapB_13225	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XapB_13240	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XapB_13260	COG3842	ATPase activity
XapB_13265	COG1176	ABC-type spermidine putrescine transport system, permease component I
XapB_13270	COG1177	transmembrane transport
XapB_13275	COG1012	belongs to the aldehyde dehydrogenase family
XapB_13290	COG4535	Mg2 and Co2 transporter CorC
XapB_13300	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XapB_13310	COG1702	phosphate starvation-inducible protein PhoH
XapB_13315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XapB_13330	COG0741	lytic transglycosylase activity
XapB_13345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XapB_13350	COG2857	Cytochrome c1
XapB_13355	COG0625	glutathione transferase activity
XapB_13360	COG2969	positive regulation of protein catabolic process
XapB_13380	COG1201	RNA secondary structure unwinding
XapB_13385	COG2094	Belongs to the DNA glycosylase MPG family
XapB_13390	COG0840	transmembrane signaling receptor activity
XapB_13395	COG0835	chemotaxis
XapB_13435	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XapB_13450	COG1570	exodeoxyribonuclease VII activity
XapB_13455	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XapB_13460	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XapB_13460	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XapB_13465	COG0802	atpase or kinase
XapB_13470	COG0860	N-Acetylmuramoyl-L-alanine amidase
XapB_13475	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XapB_13500	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_13505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XapB_13550	COG2081	HI0933 family
XapB_13555	COG4681	YaeQ
XapB_13565	COG0625	glutathione transferase activity
XapB_13575	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XapB_13580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XapB_13585	COG0513	Belongs to the DEAD box helicase family
XapB_13610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XapB_13615	COG0483	inositol monophosphate 1-phosphatase activity
XapB_13630	COG5001	Diguanylate cyclase
XapB_13630	COG3300	MHYT domain
XapB_13635	COG1509	lysine 2,3-aminomutase activity
XapB_13640	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XapB_13650	COG0402	S-adenosylhomocysteine deaminase activity
XapB_13655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XapB_13725	COG4302	ethanolamine ammonia-lyase activity
XapB_13755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XapB_13760	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XapB_13775	COG2166	iron-sulfur cluster assembly
XapB_13780	COG0215	cysteine-tRNA ligase activity
XapB_13790	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XapB_13795	COG0137	argininosuccinate synthase activity
XapB_13805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XapB_13820	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XapB_13825	COG0165	Argininosuccinate lyase
XapB_13835	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XapB_13840	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XapB_13865	COG3344	reverse transcriptase
XapB_13875	COG1294	oxidase, subunit
XapB_13885	COG4988	ABC transporter
XapB_13890	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XapB_13895	COG1278	Cold shock
XapB_13900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XapB_13920	COG1138	Cytochrome C-type biogenesis protein
XapB_13925	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XapB_13945	COG4133	protoheme IX ABC transporter activity
XapB_13950	COG0436	Aminotransferase
XapB_13970	COG1187	pseudouridine synthase activity
XapB_13975	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XapB_13980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XapB_13985	COG2350	Protein conserved in bacteria
XapB_14015	COG1175	transmembrane transport
XapB_14020	COG0395	ABC-type sugar transport system, permease component
XapB_14045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XapB_14050	COG2957	Belongs to the agmatine deiminase family
XapB_14070	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XapB_14075	COG0539	negative regulation of cytoplasmic translation
XapB_14080	COG0776	regulation of translation
XapB_14090	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XapB_14095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XapB_14105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XapB_14115	COG0475	glutathione-regulated potassium exporter activity
XapB_14115	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XapB_14125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XapB_14135	COG0519	Catalyzes the synthesis of GMP from XMP
XapB_14135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XapB_14140	COG3002	Belongs to the UPF0753 family
XapB_14145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XapB_14150	COG0583	DNA-binding transcription factor activity
XapB_14170	COG2197	response regulator
XapB_14185	COG1335	isochorismatase
XapB_14210	COG2814	Major facilitator Superfamily
XapB_14230	COG1914	H( )-stimulated, divalent metal cation uptake system
XapB_14245	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XapB_14295	COG3318	Belongs to the UPF0149 family
XapB_14295	COG3012	SEC-C Motif Domain Protein
XapB_14360	COG4456	Virulence-associated protein
XapB_14380	COG0668	transmembrane transport
XapB_14390	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XapB_14405	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_14410	COG1183	phosphatidylcholine synthase activity
XapB_14420	COG3243	poly(R)-hydroxyalkanoic acid synthase
XapB_14435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XapB_14435	COG0723	plastoquinol--plastocyanin reductase activity
XapB_14445	COG2183	response to ionizing radiation
XapB_14450	COG2205	protein histidine kinase activity
XapB_14450	COG0784	Response regulator, receiver
XapB_14525	COG0800	Aldolase
XapB_14530	COG0129	dihydroxy-acid dehydratase activity
XapB_14535	COG0363	glucosamine-6-phosphate deaminase activity
XapB_14540	COG0837	glucose binding
XapB_14545	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XapB_14570	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XapB_14590	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XapB_14600	COG4591	ABC-type transport system involved in lipoprotein release permease component
XapB_14605	COG1136	(ABC) transporter
XapB_14620	COG0811	peptide transport
XapB_14630	COG1132	(ABC) transporter
XapB_14635	COG1663	tetraacyldisaccharide 4'-kinase activity
XapB_14640	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XapB_14645	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XapB_14655	COG0322	excinuclease ABC activity
XapB_14660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XapB_14740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XapB_14775	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XapB_14805	COG1530	ribonuclease E activity
XapB_14815	COG3064	Membrane
XapB_14820	COG0428	transporter
XapB_14830	COG2154	pterin-4-alpha-carbinolamine dehydratase
XapB_14835	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XapB_14835	COG0316	Belongs to the HesB IscA family
XapB_14925	COG1073	alpha beta
XapB_14925	COG2226	methyltransferase
XapB_14960	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_14980	COG1238	metal cluster binding
XapB_15015	COG2902	Dehydrogenase
XapB_15025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapB_15030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XapB_15055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapB_15075	COG4566	intracellular signal transduction
XapB_15105	COG3685	Protein conserved in bacteria
XapB_15145	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XapB_15145	COG1648	precorrin-2 dehydrogenase activity
XapB_15155	COG0746	molybdenum cofactor guanylyltransferase activity
XapB_15170	COG0708	Exodeoxyribonuclease III
XapB_15210	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XapB_15220	COG0303	'Molybdopterin
XapB_15225	COG1160	GTP binding
XapB_15230	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XapB_15240	COG1426	Protein conserved in bacteria
XapB_15250	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XapB_15265	COG1250	3-hydroxyacyl-CoA dehydrogenase
XapB_15265	COG1024	Enoyl-CoA hydratase
XapB_15270	COG0183	Belongs to the thiolase family
XapB_15280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XapB_15285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XapB_15295	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XapB_15305	COG1674	ftsk spoiiie
XapB_15310	COG0492	ferredoxin-NADP+ reductase activity
XapB_15320	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XapB_15330	COG0542	response to heat
XapB_15345	COG0482	sulfurtransferase activity
XapB_15350	COG2915	High frequency lysogenization protein hflD homolog
XapB_15380	COG5002	protein histidine kinase activity
XapB_15400	COG0835	chemotaxis
XapB_15400	COG0784	Response regulator, receiver
XapB_15410	COG1558	bacterial-type flagellum-dependent cell motility
XapB_15415	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XapB_15430	COG4787	bacterial-type flagellum-dependent cell motility
XapB_15445	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XapB_15450	COG1706	bacterial-type flagellum-dependent cell motility
XapB_15455	COG3951	Flagellar rod assembly protein muramidase FlgJ
XapB_15455	COG1705	Flagellar rod assembly protein muramidase FlgJ
XapB_15465	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XapB_15470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XapB_15475	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
XapB_15505	COG2201	protein-glutamate methylesterase activity
XapB_15550	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_15555	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_15600	COG1677	Flagellar hook-basal body complex protein FliE
XapB_15665	COG1684	flagellar biosynthetic protein fliR
XapB_15670	COG3300	MHYT domain
XapB_15670	COG5001	Diguanylate cyclase
XapB_15695	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XapB_15725	COG0643	Histidine kinase
XapB_15725	COG0784	Response regulator, receiver
XapB_15725	COG2198	Histidine kinase
XapB_15740	COG0641	radical SAM
XapB_15775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XapB_15780	COG1360	Flagellar Motor Protein
XapB_15800	COG0745	RESPONSE REGULATOR receiver
XapB_15805	COG2198	Histidine kinase
XapB_15805	COG0643	Histidine kinase
XapB_15810	COG0840	transmembrane signaling receptor activity
XapB_15825	COG0840	transmembrane signaling receptor activity
XapB_15840	COG0840	transmembrane signaling receptor activity
XapB_15845	COG0840	transmembrane signaling receptor activity
XapB_15855	COG0840	transmembrane signaling receptor activity
XapB_15860	COG0840	transmembrane signaling receptor activity
XapB_15870	COG0840	transmembrane signaling receptor activity
XapB_15875	COG0840	transmembrane signaling receptor activity
XapB_15880	COG0840	transmembrane signaling receptor activity
XapB_15885	COG0840	transmembrane signaling receptor activity
XapB_15890	COG0840	transmembrane signaling receptor activity
XapB_15900	COG0835	chemotaxis
XapB_15910	COG0840	transmembrane signaling receptor activity
XapB_15920	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
XapB_15925	COG2201	protein-glutamate methylesterase activity
XapB_15935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XapB_15965	COG0318	PFAM AMP-dependent synthetase and ligase
XapB_16000	COG1024	Enoyl-CoA hydratase
XapB_16005	COG0784	Response regulator, receiver
XapB_16005	COG2198	Histidine kinase
XapB_16005	COG2205	protein histidine kinase activity
XapB_16015	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XapB_16025	COG3279	Response regulator of the LytR AlgR family
XapB_16075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XapB_16085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XapB_16090	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XapB_16100	COG0505	Belongs to the CarA family
XapB_16105	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XapB_16110	COG2258	MOSC domain
XapB_16160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XapB_16180	COG0277	FAD linked oxidase domain protein
XapB_16185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XapB_16195	COG0531	amino acid
XapB_16200	COG0531	amino acid
XapB_16205	COG0235	Class ii aldolase
XapB_16210	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XapB_16215	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XapB_16230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XapB_16230	COG0140	phosphoribosyl-ATP diphosphatase activity
XapB_16235	COG0107	imidazoleglycerol-phosphate synthase activity
XapB_16240	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XapB_16245	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XapB_16250	COG0131	Imidazoleglycerol-phosphate dehydratase
XapB_16250	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XapB_16255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XapB_16260	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XapB_16265	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XapB_16275	COG0124	histidyl-tRNA synthetase
XapB_16280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XapB_16375	COG1649	PFAM Uncharacterised BCR, COG1649
XapB_16375	COG0726	polysaccharide deacetylase
XapB_16520	COG0531	amino acid
XapB_16540	COG0006	proline dipeptidase activity
XapB_16550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XapB_16565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XapB_16570	COG3938	Belongs to the proline racemase family
XapB_16580	COG0552	protein localization to endoplasmic reticulum
XapB_16590	COG1194	a g-specific adenine glycosylase
XapB_16595	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XapB_16600	COG4191	Histidine kinase
XapB_16600	COG0784	Response regulator, receiver
XapB_16645	COG3040	lipid binding
XapB_16660	COG1960	acyl-CoA dehydrogenase activity
XapB_16670	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XapB_16690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XapB_16695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XapB_16700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XapB_16725	COG0438	transferase activity, transferring glycosyl groups
XapB_16735	COG0438	transferase activity, transferring glycosyl groups
XapB_16740	COG0438	transferase activity, transferring glycosyl groups
XapB_16790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XapB_16790	COG0072	phenylalanine-tRNA ligase activity
XapB_16795	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XapB_16810	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XapB_16815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XapB_16865	COG2948	multi-organism process
XapB_16885	COG3505	Type IV secretory pathway VirD4
XapB_16900	COG0556	nucleotide-excision repair
XapB_16955	COG1611	Belongs to the LOG family
XapB_16970	COG2095	MarC family integral membrane protein
XapB_16980	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XapB_17015	COG1185	polyribonucleotide nucleotidyltransferase activity
XapB_17020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XapB_17025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XapB_17030	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XapB_17035	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XapB_17040	COG0195	Participates in both transcription termination and antitermination
XapB_17045	COG0779	Required for maturation of 30S ribosomal subunits
XapB_17055	COG1007	ATP synthesis coupled electron transport
XapB_17075	COG0839	Belongs to the complex I subunit 6 family
XapB_17080	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XapB_17085	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XapB_17095	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XapB_17100	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XapB_17105	COG0649	NAD binding
XapB_17110	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XapB_17115	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XapB_17120	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XapB_17135	COG0149	triose-phosphate isomerase activity
XapB_17140	COG0300	oxidoreductase activity
XapB_17170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XapB_17175	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XapB_17180	COG0159	tryptophan synthase activity
XapB_17200	COG0135	phosphoribosylanthranilate isomerase activity
XapB_17205	COG0101	tRNA pseudouridine synthase activity
XapB_17225	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XapB_17230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XapB_17235	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XapB_17240	COG2890	protein-(glutamine-N5) methyltransferase activity
XapB_17250	COG0688	phosphatidylethanolamine metabolic process
XapB_17265	COG0433	COG0433 Predicted ATPase
XapB_17270	COG0494	nUDIX hydrolase
XapB_17290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XapB_17295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XapB_17310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XapB_17395	COG3179	chitinase
XapB_17590	COG0717	Belongs to the dCTP deaminase family
XapB_17600	COG0489	protein tyrosine kinase activity
XapB_17625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XapB_17635	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XapB_17655	COG0534	Mate efflux family protein
XapB_17660	COG0335	large ribosomal subunit rRNA binding
XapB_17665	COG0336	Belongs to the RNA methyltransferase TrmD family
XapB_17670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XapB_17675	COG0228	four-way junction DNA binding
XapB_17680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XapB_17690	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XapB_17695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XapB_17735	COG2205	protein histidine kinase activity
XapB_17735	COG3850	Histidine kinase
XapB_17735	COG4999	Histidine kinase
XapB_17735	COG3437	response regulator, receiver
XapB_17740	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XapB_17750	COG2205	protein histidine kinase activity
XapB_17755	COG5507	3-demethylubiquinone-9 3-methyltransferase
XapB_17765	COG4771	TonB-dependent receptor
XapB_17790	COG2172	sigma factor antagonist activity
XapB_17795	COG1366	Belongs to the anti-sigma-factor antagonist family
XapB_17800	COG1366	Belongs to the anti-sigma-factor antagonist family
XapB_17810	COG0326	Molecular chaperone. Has ATPase activity
XapB_17815	COG2207	Transcriptional regulator
XapB_17825	COG3152	Membrane
XapB_17840	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XapB_17845	COG1845	cytochrome c oxidase, subunit III
XapB_17850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XapB_17865	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XapB_17870	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XapB_17875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XapB_17880	COG0196	riboflavin kinase activity
XapB_17890	COG0268	Binds directly to 16S ribosomal RNA
XapB_17895	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XapB_17900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XapB_17905	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XapB_17910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XapB_17915	COG0824	Thioesterase
XapB_17965	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XapB_17975	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
XapB_18005	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XapB_18020	COG2197	response regulator
XapB_18025	COG4585	Histidine kinase
XapB_18040	COG0850	regulation of cytokinetic process
XapB_18045	COG2894	cell division
XapB_18050	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XapB_18060	COG0642	Histidine kinase
XapB_18065	COG0745	RESPONSE REGULATOR receiver
XapB_18080	COG2194	sulfuric ester hydrolase activity
XapB_18095	COG2814	Major facilitator Superfamily
XapB_18100	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XapB_18100	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XapB_18110	COG0656	L-ascorbic acid biosynthetic process
XapB_18115	COG0753	catalase activity
XapB_18140	COG1917	Cupin 2, conserved barrel domain protein
XapB_18140	COG2207	Transcriptional regulator
XapB_18200	COG0492	ferredoxin-NADP+ reductase activity
XapB_18210	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_18215	COG3537	Alpha-1,2-mannosidase
XapB_18225	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_18230	COG3387	PFAM Glycoside hydrolase 15-related
XapB_18240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XapB_18280	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
XapB_18305	COG0732	type I restriction modification DNA specificity domain
XapB_18335	COG1309	transcriptional regulator
XapB_18340	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_18345	COG0308	aminopeptidase N
XapB_18350	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XapB_18360	COG0330	HflC and HflK could
XapB_18365	COG0330	HflC and HflK could
XapB_18385	COG0678	peroxiredoxin activity
XapB_18395	COG4953	penicillin-binding protein 1C
XapB_18415	COG2373	Large extracellular alpha-helical protein
XapB_18450	COG3609	addiction module antidote protein, CC2985 family
XapB_18470	COG3829	transcription factor binding
XapB_18495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XapB_18500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XapB_18515	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_18530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XapB_18535	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XapB_18540	COG1399	metal-binding, possibly nucleic acid-binding protein
XapB_18545	COG0424	maF-like protein
XapB_18575	COG0714	Associated with various cellular activities
XapB_18595	COG0537	adenosine 5'-monophosphoramidase activity
XapB_18600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XapB_18605	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XapB_18625	COG0314	molybdopterin synthase activity
XapB_18630	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XapB_18635	COG0315	cyclic pyranopterin monophosphate synthase activity
XapB_18640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XapB_18645	COG1234	tRNA 3'-trailer cleavage
XapB_18650	COG3642	lipopolysaccharide core region biosynthetic process
XapB_18655	COG0859	PFAM glycosyl transferase family 9
XapB_18670	COG0631	protein serine/threonine phosphatase activity
XapB_18675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XapB_18680	COG0328	RNA-DNA hybrid ribonuclease activity
XapB_18690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XapB_18700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XapB_18725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XapB_18735	COG0544	peptidyl-prolyl cis-trans isomerase activity
XapB_18745	COG3852	Histidine kinase
XapB_18775	COG0473	3-isopropylmalate dehydrogenase activity
XapB_18790	COG4783	chaperone-mediated protein folding
XapB_18805	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XapB_18815	COG0438	transferase activity, transferring glycosyl groups
XapB_18820	COG0671	phosphoesterase, PA-phosphatase related
XapB_18825	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XapB_18845	COG2833	Protein of unknown function (DUF455)
XapB_18865	COG0285	dihydrofolate synthase activity
XapB_18875	COG0406	alpha-ribazole phosphatase activity
XapB_18910	COG1063	alcohol dehydrogenase
XapB_18920	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XapB_18925	COG4208	sulfate ABC transporter
XapB_18930	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XapB_18935	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XapB_18940	COG0156	8-amino-7-oxononanoate synthase activity
XapB_18975	COG0446	pyridine nucleotide-disulphide oxidoreductase
XapB_18975	COG1902	pentaerythritol trinitrate reductase activity
XapB_18995	COG0625	glutathione transferase activity
XapB_19005	COG0039	L-malate dehydrogenase activity
XapB_19010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XapB_19025	COG0154	amidase activity
XapB_19035	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XapB_19055	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XapB_19060	COG0203	ribosomal protein L17
XapB_19085	COG0201	protein transport
XapB_19090	COG0200	Binds to the 23S rRNA
XapB_19095	COG1841	ribosomal large subunit assembly
XapB_19105	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XapB_19110	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XapB_19115	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XapB_19125	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XapB_19130	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XapB_19140	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XapB_19145	COG0255	Belongs to the universal ribosomal protein uL29 family
XapB_19150	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XapB_19155	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XapB_19165	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XapB_19170	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XapB_19175	COG0089	rRNA binding
XapB_19180	COG0088	Forms part of the polypeptide exit tunnel
XapB_19185	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XapB_19190	COG0051	transcription antitermination factor activity, RNA binding
XapB_19195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XapB_19200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XapB_19205	COG0049	tRNA binding
XapB_19210	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XapB_19215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XapB_19220	COG0085	RNA polymerase activity
XapB_19225	COG0222	ribosome binding
XapB_19230	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XapB_19235	COG0081	regulation of translation
XapB_19240	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XapB_19245	COG0250	Participates in transcription elongation, termination and antitermination
XapB_19260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XapB_19280	COG0012	GTP binding
XapB_19285	COG0193	aminoacyl-tRNA hydrolase activity
XapB_19290	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XapB_19295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XapB_19305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XapB_19310	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XapB_19320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XapB_19325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XapB_19355	COG1254	Belongs to the acylphosphatase family
XapB_19365	COG1295	ribonuclease BN
XapB_19390	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XapB_19395	COG1404	Belongs to the peptidase S8 family
XapB_19405	COG1404	Belongs to the peptidase S8 family
XapB_19415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XapB_19435	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XapB_19455	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XapB_19505	COG2890	protein-(glutamine-N5) methyltransferase activity
XapB_19515	COG3634	alkyl hydroperoxide reductase activity
XapB_19520	COG0583	DNA-binding transcription factor activity
XapB_19530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XapB_19535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XapB_19545	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XapB_19580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XapB_19590	COG0697	spore germination
XapB_19610	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XapB_19625	COG3386	PFAM SMP-30 Gluconolaconase
XapB_19645	COG1024	Enoyl-CoA hydratase
XapB_19655	COG0318	PFAM AMP-dependent synthetase and ligase
XapB_19660	COG0583	DNA-binding transcription factor activity
XapB_19665	COG3384	dioxygenase
XapB_19695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XapB_19700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XapB_19715	COG2096	Adenosyltransferase
XapB_19720	COG0123	including yeast histone deacetylase and acetoin utilization protein
XapB_19725	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XapB_19730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XapB_19735	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XapB_19740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XapB_19745	COG2967	ApaG domain
XapB_19750	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XapB_19770	COG0747	negative chemotaxis
XapB_19795	COG0431	NADPH-dependent FMN reductase
XapB_19800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XapB_19810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XapB_19815	COG1116	anion transmembrane transporter activity
XapB_19825	COG3829	transcription factor binding
XapB_19840	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XapB_19845	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XapB_19880	COG0588	phosphoglycerate mutase activity
XapB_19885	COG1515	deoxyribonuclease V activity
XapB_19895	COG1741	Belongs to the pirin family
XapB_19910	COG1741	Belongs to the pirin family
XapB_19915	COG1966	Carbon starvation protein
XapB_19920	COG2879	small protein
XapB_19970	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
XapB_19975	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XapB_19980	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XapB_19985	COG2080	2 iron, 2 sulfur cluster binding
XapB_19990	COG3321	synthase
XapB_19990	COG1028	Short-chain dehydrogenase reductase Sdr
XapB_19990	COG0604	alcohol dehydrogenase
XapB_19995	COG5001	Diguanylate cyclase
XapB_19995	COG4251	negative regulation of phosphorylation
XapB_19995	COG3706	GGDEF domain
XapB_19995	COG2203	Gaf domain
XapB_20000	COG0629	single-stranded DNA binding
XapB_20005	COG0142	geranyltranstransferase activity
XapB_20020	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XapB_20035	COG0527	aspartate kinase activity
XapB_20040	COG0384	phenazine biosynthesis protein PhzF
XapB_20055	COG1764	response to oxidative stress
XapB_20060	COG0540	Belongs to the ATCase OTCase family
XapB_20065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XapB_20070	COG1678	Uncharacterized ACR, COG1678
XapB_20080	COG0519	Catalyzes the synthesis of GMP from XMP
XapB_20090	COG5297	Belongs to the glycosyl hydrolase family 6
XapB_20105	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XapB_20120	COG0739	heme binding
XapB_20140	COG0693	protein deglycase activity
XapB_20150	COG1959	2 iron, 2 sulfur cluster binding
XapB_20155	COG0719	Fe-S assembly protein
XapB_20160	COG0396	ATPase activity
XapB_20165	COG0719	Fe-S assembly protein
XapB_20170	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XapB_20180	COG2146	nitrite reductase [NAD(P)H] activity
XapB_20185	COG4774	siderophore transport
XapB_20190	COG3128	pkhd-type hydroxylase
XapB_20215	COG1477	protein flavinylation
XapB_20220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XapB_20235	COG1555	photosystem II stabilization
XapB_20250	COG3178	'Phosphotransferase
XapB_20255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XapB_20265	COG0628	permease
XapB_20275	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XapB_20285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XapB_20305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XapB_20310	COG0271	Belongs to the BolA IbaG family
XapB_20320	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XapB_20330	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XapB_20335	COG1137	ATPase activity
XapB_20350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XapB_20355	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XapB_20360	COG1660	Displays ATPase and GTPase activities
XapB_20370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XapB_20375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XapB_20385	COG2239	Acts as a magnesium transporter
XapB_20400	COG1294	oxidase, subunit
XapB_20405	COG1271	oxidase subunit
XapB_20425	COG1113	amino acid transport
XapB_20455	COG2197	response regulator
XapB_20460	COG0531	amino acid
XapB_20490	COG1234	tRNA 3'-trailer cleavage
XapB_20555	COG2814	Major facilitator Superfamily
XapB_20565	COG0754	glutathionylspermidine amidase activity
XapB_20590	COG1842	Phage shock protein A
XapB_20600	COG0259	pyridoxamine-phosphate oxidase activity
XapB_20605	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XapB_20610	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XapB_20620	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XapB_20625	COG0477	Major facilitator Superfamily
XapB_20645	COG2205	protein histidine kinase activity
XapB_20645	COG2198	Histidine kinase
XapB_20645	COG0784	Response regulator, receiver
XapB_20650	COG2353	YceI-like domain
XapB_20670	COG1760	l-serine dehydratase
XapB_20685	COG0527	aspartate kinase activity
XapB_20685	COG0460	homoserine dehydrogenase
XapB_20690	COG0626	cystathionine gamma-synthase activity
XapB_20695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XapB_20700	COG0739	heme binding
XapB_20705	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XapB_20710	COG1272	protein, Hemolysin III
XapB_20715	COG2982	Protein involved in outer membrane biogenesis
XapB_20720	COG0516	GMP reductase activity
XapB_20720	COG0517	IMP dehydrogenase activity
XapB_20725	COG0463	Glycosyl transferase, family 2
XapB_20730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XapB_20735	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XapB_20745	COG4771	TonB-dependent receptor
XapB_20760	COG1309	transcriptional regulator
XapB_20770	COG1960	acyl-CoA dehydrogenase activity
XapB_20795	COG0509	glycine decarboxylation via glycine cleavage system
XapB_20800	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XapB_20820	COG1742	UPF0060 membrane protein
XapB_20825	COG3956	TIGRFAM MazG family protein
XapB_20835	COG0494	nUDIX hydrolase
XapB_20845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XapB_20850	COG0837	glucose binding
XapB_20865	COG3858	chitin binding
XapB_20865	COG1388	LysM domain
XapB_20880	COG1472	Belongs to the glycosyl hydrolase 3 family
XapB_20915	COG3537	Alpha-1,2-mannosidase
XapB_20955	COG3142	Participates in the control of copper homeostasis
XapB_20960	COG1446	asparaginase
XapB_20990	COG2198	Histidine kinase
XapB_20990	COG0643	Histidine kinase
XapB_20990	COG0784	Response regulator, receiver
XapB_20995	COG0840	transmembrane signaling receptor activity
XapB_21000	COG0835	chemotaxis
XapB_21015	COG0189	ligase activity
XapB_21025	COG1397	ADP-ribosylglycohydrolase
XapB_21035	COG1199	ATP-dependent helicase activity
XapB_21050	COG1215	transferase activity, transferring glycosyl groups
XapB_21070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XapB_21080	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
XapB_21085	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
XapB_21090	COG0535	radical SAM domain protein
XapB_21095	COG0535	radical SAM domain protein
XapB_21120	COG1643	Atp-dependent helicase
XapB_21125	COG0783	Belongs to the Dps family
XapB_21135	COG0514	ATP-dependent DNA helicase (RecQ)
XapB_21170	COG0840	transmembrane signaling receptor activity
XapB_21190	COG3920	Histidine kinase
XapB_21195	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XapB_21205	COG0602	queuosine metabolic process
XapB_21215	COG2885	chlorophyll binding
XapB_21220	COG0823	Involved in the tonB-independent uptake of proteins
XapB_21230	COG0848	biopolymer transport protein
XapB_21240	COG0824	Thioesterase
XapB_21245	COG2255	four-way junction helicase activity
XapB_21255	COG3158	transport of potassium into the cell
XapB_21260	COG0632	four-way junction helicase activity
XapB_21265	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XapB_21270	COG0217	transcriptional regulatory protein
XapB_21285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XapB_21300	COG0477	Major facilitator Superfamily
XapB_21345	COG0488	(ABC) transporter
XapB_21385	COG4651	solute:proton antiporter activity
XapB_21385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XapB_21410	COG4772	TonB-dependent receptor
XapB_21420	COG4264	IucA IucC family
XapB_21435	COG0019	diaminopimelate decarboxylase activity
XapB_21465	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XapB_21475	COG1492	cobalamin metabolic process
XapB_21505	COG4206	TonB-dependent receptor
XapB_21510	COG0542	response to heat
XapB_21515	COG1116	anion transmembrane transporter activity
XapB_21520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XapB_21525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XapB_21530	COG0667	Aldo Keto reductase
XapB_21535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XapB_21540	COG4771	TonB-dependent receptor
XapB_21550	COG2827	Endonuclease containing a URI domain
XapB_21595	COG1877	trehalose-phosphatase activity
XapB_21600	COG3387	PFAM Glycoside hydrolase 15-related
XapB_21620	COG0840	transmembrane signaling receptor activity
XapB_21625	COG3011	Protein conserved in bacteria
XapB_21640	COG0564	pseudouridine synthase activity
XapB_21645	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XapB_21655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XapB_21655	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XapB_21665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XapB_21670	COG0045	succinate-CoA ligase (ADP-forming) activity
XapB_21715	COG1459	type II secretion system
XapB_21720	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XapB_21725	COG0237	dephospho-CoA kinase activity
XapB_21745	COG0436	Aminotransferase
XapB_21775	COG0726	polysaccharide deacetylase
XapB_21780	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XapB_21795	COG3964	amidohydrolase
XapB_21800	COG0402	S-adenosylhomocysteine deaminase activity
XapB_21835	COG1307	EDD domain protein, DegV family
XapB_21840	COG0242	peptide deformylase activity
XapB_21870	COG0457	Tetratricopeptide repeat
XapB_21875	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
XapB_21880	COG1215	transferase activity, transferring glycosyl groups
XapB_21885	COG1215	transferase activity, transferring glycosyl groups
XapB_21900	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XapB_21965	COG2188	Transcriptional regulator
XapB_21980	COG1450	Type ii and iii secretion system protein
XapB_21995	COG3166	PFAM Fimbrial assembly family protein
XapB_22000	COG3156	type II secretion system protein K
XapB_22005	COG4795	General secretion pathway protein
XapB_22010	COG2165	general secretion pathway protein
XapB_22015	COG4970	Tfp pilus assembly protein FimT
XapB_22020	COG2165	general secretion pathway protein
XapB_22025	COG1459	type II secretion system
XapB_22035	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XapB_22040	COG1404	Belongs to the peptidase S8 family
XapB_22045	COG5295	Hep Hag repeat protein
XapB_22050	COG1404	Belongs to the peptidase S8 family
XapB_22055	COG5295	Hep Hag repeat protein
XapB_22065	COG0047	phosphoribosylformylglycinamidine synthase activity
XapB_22065	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XapB_22075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XapB_22085	COG4974	Belongs to the 'phage' integrase family
XapB_22100	COG0795	lipopolysaccharide-transporting ATPase activity
XapB_22110	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XapB_22125	COG0525	valine-tRNA ligase activity
XapB_22145	COG0741	lytic transglycosylase activity
XapB_22165	COG1183	phosphatidylcholine synthase activity
XapB_22175	COG0442	prolyl-tRNA aminoacylation
XapB_22190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XapB_22195	COG1127	ABC transporter
XapB_22200	COG3218	ABC-type transport auxiliary lipoprotein component
XapB_22200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XapB_22235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XapB_22240	COG0662	Cupin 2, conserved barrel domain protein
XapB_22240	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XapB_22270	COG2086	electron transfer activity
XapB_22285	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XapB_22285	COG0546	phosphoglycolate phosphatase activity
XapB_22290	COG0277	FAD linked oxidase domain protein
XapB_22305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XapB_22340	COG1216	Glycosyl transferase, family 2
XapB_22340	COG0438	transferase activity, transferring glycosyl groups
XapB_22360	COG0626	cystathionine gamma-synthase activity
XapB_22390	COG0625	glutathione transferase activity
XapB_22405	COG0513	Belongs to the DEAD box helicase family
XapB_22415	COG4206	TonB-dependent receptor
XapB_22425	COG0720	synthase
XapB_22435	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XapB_22445	COG1956	GAF domain-containing protein
XapB_22455	COG2819	hydrolase of the alpha beta superfamily
XapB_22470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XapB_22475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XapB_22490	COG0339	signal peptide processing
XapB_22505	COG2132	Multicopper oxidase
XapB_22545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XapB_22550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XapB_22555	COG1136	(ABC) transporter
XapB_22555	COG4591	ABC-type transport system involved in lipoprotein release permease component
XapB_22560	COG0577	efflux transmembrane transporter activity
XapB_22565	COG0577	efflux transmembrane transporter activity
XapB_22580	COG4191	Histidine kinase
XapB_22585	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XapB_22600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XapB_22605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XapB_22610	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XapB_22615	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XapB_22620	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XapB_22625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XapB_22635	COG0356	it plays a direct role in the translocation of protons across the membrane
XapB_22655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XapB_22665	COG0508	dehydrogenase complex catalyzes the overall conversion of
XapB_22710	COG2011	ABC-type metal ion transport system permease component
XapB_22715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XapB_22720	COG0697	spore germination
XapB_22725	COG1666	GTP binding
XapB_22735	COG5002	protein histidine kinase activity
XapB_22735	COG0784	Response regulator, receiver
XapB_22735	COG2198	Histidine kinase
XapB_22760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XapB_22765	COG1187	pseudouridine synthase activity
XapB_22770	COG2813	Specifically methylates the guanine in position
XapB_22790	COG2202	Pas domain
XapB_22790	COG2205	protein histidine kinase activity
XapB_22810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XapB_22815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XapB_22880	COG0842	Transport permease protein
XapB_22885	COG1131	(ABC) transporter
XapB_22890	COG0025	NhaP-type Na H and K H
XapB_22900	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XapB_22905	COG1573	uracil-dna glycosylase
XapB_22915	COG3384	dioxygenase
XapB_22990	COG1192	Involved in chromosome partitioning
XapB_23085	COG3704	protein secretion by the type IV secretion system
XapB_23095	COG3504	Conjugal transfer protein
XapB_23100	COG2948	multi-organism process
XapB_23245	COG1192	Involved in chromosome partitioning
XapB_23315	COG4691	Plasmid stability protein
XapB_23320	COG1487	ribonuclease activity
XapB_23380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XapB_23395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XapB_23510	COG1192	Involved in chromosome partitioning
XapB_23755	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XapB_23825	COG3318	Belongs to the UPF0149 family
XapB_23825	COG3012	SEC-C Motif Domain Protein
XapB_23945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XapB_23980	COG3846	protein secretion by the type IV secretion system
XapB_23990	COG3451	type IV secretory pathway VirB4
XapB_24000	COG3838	Conjugal transfer protein Trbc
XapB_24005	COG4962	Type ii secretion system protein e
XapB_24095	COG0489	protein tyrosine kinase activity