locus-tag	class	description
J151_00006	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J151_00037	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J151_00042	COG1192	Involved in chromosome partitioning
J151_00050	COG2951	lytic endotransglycosylase activity
J151_00051	COG4644	lycopene metabolic process
J151_00081	COG2948	multi-organism process
J151_00082	COG3504	Conjugal transfer protein
J151_00103	COG4456	Virulence-associated protein
J151_00104	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J151_00112	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J151_00113	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J151_00115	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J151_00117	COG0187	DNA topoisomerase II activity
J151_00119	COG0501	Belongs to the peptidase M48B family
J151_00125	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
J151_00127	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J151_00136	COG0793	Belongs to the peptidase S41A family
J151_00137	COG4942	peptidase
J151_00139	COG2234	aminopeptidase activity
J151_00141	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J151_00142	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J151_00143	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J151_00144	COG1064	alcohol dehydrogenase
J151_00145	COG0493	'glutamate synthase
J151_00146	COG0067	glutamate synthase
J151_00146	COG0069	glutamate synthase activity
J151_00146	COG0070	glutamate synthase
J151_00150	COG2366	antibiotic biosynthetic process
J151_00155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J151_00158	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
J151_00159	COG0297	glycogen (starch) synthase activity
J151_00159	COG0438	transferase activity, transferring glycosyl groups
J151_00163	COG0367	asparagine synthase
J151_00169	COG1132	(ABC) transporter
J151_00193	COG1205	dead DEAH box helicase
J151_00193	COG1111	helicase
J151_00194	COG1272	protein, Hemolysin III
J151_00197	COG0300	oxidoreductase activity
J151_00198	COG1028	Short-chain dehydrogenase reductase Sdr
J151_00203	COG2249	NAD(P)H dehydrogenase (quinone) activity
J151_00205	COG2963	transposase activity
J151_00214	COG3237	CsbD-like
J151_00223	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J151_00224	COG0477	Major facilitator Superfamily
J151_00232	COG0714	Associated with various cellular activities
J151_00238	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
J151_00240	COG4772	TonB-dependent receptor
J151_00242	COG0662	Cupin 2, conserved barrel domain protein
J151_00243	COG1012	belongs to the aldehyde dehydrogenase family
J151_00248	COG1304	FMN binding
J151_00250	COG4585	Histidine kinase
J151_00251	COG2197	response regulator
J151_00255	COG3710	Transcriptional regulator
J151_00256	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J151_00269	COG2963	transposase activity
J151_00271	COG0366	Alpha amylase catalytic
J151_00272	COG0366	Alpha amylase catalytic
J151_00273	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J151_00277	COG0657	acetylesterase activity
J151_00277	COG2755	lipolytic protein G-D-S-L family
J151_00279	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J151_00282	COG3507	Belongs to the glycosyl hydrolase 43 family
J151_00283	COG1609	Transcriptional regulator
J151_00284	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
J151_00285	COG1028	Short-chain dehydrogenase reductase Sdr
J151_00287	COG2755	lipolytic protein G-D-S-L family
J151_00290	COG3186	Phenylalanine-4-hydroxylase
J151_00291	COG1522	sequence-specific DNA binding
J151_00293	COG1752	Esterase of the alpha-beta hydrolase superfamily
J151_00295	COG1119	ATPase activity
J151_00298	COG1125	glycine betaine transport
J151_00301	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J151_00304	COG1396	sequence-specific DNA binding
J151_00308	COG0489	protein tyrosine kinase activity
J151_00309	COG2062	phosphohistidine phosphatase, SixA
J151_00311	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J151_00320	COG1968	undecaprenyl-diphosphatase activity
J151_00321	COG0174	glutamine synthetase
J151_00322	COG0347	Belongs to the P(II) protein family
J151_00323	COG0004	ammonium transporteR
J151_00324	COG3852	Histidine kinase
J151_00325	COG2204	response regulator
J151_00326	COG2032	superoxide dismutase activity
J151_00327	COG2032	superoxide dismutase activity
J151_00328	COG0346	lactoylglutathione lyase activity
J151_00330	COG0183	Belongs to the thiolase family
J151_00337	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J151_00338	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
J151_00339	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J151_00341	COG0028	Belongs to the TPP enzyme family
J151_00342	COG2205	protein histidine kinase activity
J151_00347	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J151_00350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J151_00352	COG0596	Alpha beta hydrolase
J151_00354	COG0318	PFAM AMP-dependent synthetase and ligase
J151_00356	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J151_00358	COG1181	Belongs to the D-alanine--D-alanine ligase family
J151_00360	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J151_00362	COG0564	pseudouridine synthase activity
J151_00367	COG0339	signal peptide processing
J151_00372	COG0475	glutathione-regulated potassium exporter activity
J151_00373	COG0583	DNA-binding transcription factor activity
J151_00374	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J151_00375	COG2224	Isocitrate lyase
J151_00376	COG3706	GGDEF domain
J151_00383	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J151_00384	COG1960	acyl-CoA dehydrogenase activity
J151_00395	COG0523	cobalamin synthesis protein
J151_00397	COG0697	spore germination
J151_00399	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
J151_00400	COG1846	Transcriptional regulator
J151_00401	COG1764	response to oxidative stress
J151_00406	COG2130	NADP-dependent
J151_00409	COG1187	pseudouridine synthase activity
J151_00412	COG1643	Atp-dependent helicase
J151_00413	COG4807	Protein conserved in bacteria
J151_00414	COG2351	hydroxyisourate hydrolase activity
J151_00415	COG2072	flavoprotein involved in K transport
J151_00419	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J151_00426	COG1957	nucleoside hydrolase
J151_00428	COG2252	PERMEase
J151_00432	COG0084	hydrolase, TatD family'
J151_00435	COG0583	DNA-binding transcription factor activity
J151_00436	COG2814	Major facilitator Superfamily
J151_00439	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J151_00440	COG1902	pentaerythritol trinitrate reductase activity
J151_00444	COG0745	RESPONSE REGULATOR receiver
J151_00445	COG2205	protein histidine kinase activity
J151_00446	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J151_00448	COG1538	Outer membrane efflux protein
J151_00450	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J151_00451	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J151_00452	COG0583	DNA-binding transcription factor activity
J151_00458	COG0702	epimerase
J151_00459	COG1733	regulation of RNA biosynthetic process
J151_00464	COG2963	transposase activity
J151_00466	COG0129	dihydroxy-acid dehydratase activity
J151_00469	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
J151_00480	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J151_00481	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J151_00486	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
J151_00487	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
J151_00489	COG3485	protocatechuate 3,4-dioxygenase
J151_00490	COG3485	protocatechuate 3,4-dioxygenase
J151_00492	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J151_00493	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J151_00495	COG1414	Transcriptional regulator
J151_00499	COG0445	tRNA wobble uridine modification
J151_00507	COG2267	carboxylic ester hydrolase activity
J151_00509	COG0156	8-amino-7-oxononanoate synthase activity
J151_00510	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J151_00511	COG1040	competence protein
J151_00512	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J151_00529	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J151_00543	COG3264	Mechanosensitive ion channel
J151_00543	COG1511	domain protein
J151_00544	COG1368	sulfuric ester hydrolase activity
J151_00545	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J151_00546	COG2354	Protein conserved in bacteria
J151_00547	COG0745	RESPONSE REGULATOR receiver
J151_00547	COG3706	GGDEF domain
J151_00548	COG0297	glycogen (starch) synthase activity
J151_00549	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J151_00550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J151_00555	COG0702	epimerase
J151_00556	COG1028	Short-chain dehydrogenase reductase Sdr
J151_00562	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J151_00563	COG1028	Short-chain dehydrogenase reductase Sdr
J151_00565	COG0513	Belongs to the DEAD box helicase family
J151_00570	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J151_00572	COG3483	tryptophan 2,3-dioxygenase activity
J151_00573	COG3104	oligopeptide transport
J151_00577	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
J151_00580	COG1320	monovalent cation:proton antiporter activity
J151_00581	COG2212	antiporter activity
J151_00583	COG0651	ATP synthesis coupled electron transport
J151_00584	COG1006	Multisubunit Na H antiporter MnhC subunit
J151_00585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J151_00585	COG2111	Na H antiporter
J151_00589	COG3179	chitinase
J151_00593	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J151_00594	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
J151_00597	COG0456	acetyltransferase
J151_00598	COG1597	lipid kinase activity
J151_00603	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J151_00604	COG0134	indole-3-glycerol-phosphate synthase activity
J151_00606	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J151_00607	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
J151_00609	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
J151_00610	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J151_00611	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J151_00614	COG1051	belongs to the nudix hydrolase family
J151_00621	COG0316	Belongs to the HesB IscA family
J151_00625	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
J151_00628	COG2814	Major facilitator Superfamily
J151_00629	COG0583	DNA-binding transcription factor activity
J151_00630	COG2814	Major facilitator Superfamily
J151_00631	COG1289	transmembrane transporter activity
J151_00632	COG0151	Belongs to the GarS family
J151_00634	COG0138	bifunctional purine biosynthesis protein purh
J151_00635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J151_00636	COG2267	carboxylic ester hydrolase activity
J151_00637	COG2453	phosphatase
J151_00637	COG0671	phosphoesterase, PA-phosphatase related
J151_00642	COG4589	Belongs to the CDS family
J151_00643	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
J151_00648	COG2264	protein methyltransferase activity
J151_00651	COG0439	Biotin carboxylase
J151_00653	COG0511	ligase activity, forming carbon-carbon bonds
J151_00654	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
J151_00656	COG1324	tolerance protein
J151_00661	COG0300	oxidoreductase activity
J151_00662	COG2356	endonuclease I
J151_00663	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J151_00664	COG0459	protein refolding
J151_00667	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J151_00670	COG3386	PFAM SMP-30 Gluconolaconase
J151_00672	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
J151_00673	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J151_00676	COG0778	Nitroreductase
J151_00677	COG2353	YceI-like domain
J151_00682	COG3052	prosthetic group binding
J151_00686	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
J151_00688	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J151_00690	COG1802	Transcriptional regulator
J151_00700	COG2963	transposase activity
J151_00701	COG4221	oxidoreductase activity
J151_00704	COG4221	oxidoreductase activity
J151_00706	COG0435	Glutathione S-transferase
J151_00711	COG2409	Drug exporters of the RND superfamily
J151_00712	COG1506	peptidase
J151_00712	COG0823	Involved in the tonB-independent uptake of proteins
J151_00714	COG3706	GGDEF domain
J151_00718	COG0697	spore germination
J151_00722	COG1113	amino acid transport
J151_00724	COG0598	Magnesium transport protein CorA
J151_00726	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
J151_00733	COG5001	Diguanylate cyclase
J151_00734	COG0840	transmembrane signaling receptor activity
J151_00735	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J151_00735	COG5297	Belongs to the glycosyl hydrolase family 6
J151_00736	COG0659	secondary active sulfate transmembrane transporter activity
J151_00737	COG3706	GGDEF domain
J151_00740	COG2943	transferase activity, transferring hexosyl groups
J151_00742	COG3275	phosphorelay sensor kinase activity
J151_00744	COG0181	hydroxymethylbilane synthase activity
J151_00749	COG1505	serine-type exopeptidase activity
J151_00750	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J151_00753	COG2832	Protein of unknown function (DUF454)
J151_00755	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J151_00757	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
J151_00758	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
J151_00759	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
J151_00764	COG2226	methyltransferase
J151_00765	COG5001	Diguanylate cyclase
J151_00765	COG3300	MHYT domain
J151_00766	COG0308	aminopeptidase N
J151_00775	COG3284	Transcriptional regulator
J151_00777	COG1077	Cell shape determining protein MreB Mrl
J151_00778	COG1792	Involved in formation and maintenance of cell shape
J151_00781	COG0772	Belongs to the SEDS family
J151_00783	COG2951	lytic endotransglycosylase activity
J151_00784	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J151_00785	COG1686	Belongs to the peptidase S11 family
J151_00787	COG2921	Belongs to the UPF0250 family
J151_00788	COG0321	lipoyl(octanoyl) transferase activity
J151_00789	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J151_00792	COG0583	DNA-binding transcription factor activity
J151_00794	COG1051	belongs to the nudix hydrolase family
J151_00794	COG1056	cytidyltransferase-related domain
J151_00801	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
J151_00802	COG0673	inositol 2-dehydrogenase activity
J151_00803	COG2823	Periplasmic or secreted lipoprotein
J151_00804	COG4251	negative regulation of phosphorylation
J151_00805	COG0784	Response regulator, receiver
J151_00806	COG4191	Histidine kinase
J151_00807	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J151_00818	COG1459	type II secretion system
J151_00829	COG3250	beta-galactosidase activity
J151_00835	COG1609	Transcriptional regulator
J151_00836	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J151_00837	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J151_00839	COG0617	tRNA 3'-terminal CCA addition
J151_00840	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
J151_00841	COG1012	belongs to the aldehyde dehydrogenase family
J151_00842	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J151_00844	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J151_00848	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J151_00849	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J151_00852	COG2205	protein histidine kinase activity
J151_00853	COG0745	RESPONSE REGULATOR receiver
J151_00858	COG3791	Glutathione-dependent formaldehyde-activating
J151_00860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J151_00862	COG0697	spore germination
J151_00864	COG0488	(ABC) transporter
J151_00866	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J151_00867	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J151_00869	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J151_00869	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J151_00874	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J151_00875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J151_00876	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
J151_00880	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
J151_00881	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
J151_00882	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
J151_00883	COG2205	protein histidine kinase activity
J151_00884	COG0745	RESPONSE REGULATOR receiver
J151_00887	COG0277	FAD linked oxidase domain protein
J151_00888	COG1988	membrane-bound metal-dependent
J151_00889	COG0792	nuclease activity
J151_00896	COG2001	Belongs to the MraZ family
J151_00897	COG0275	rRNA processing
J151_00898	COG3116	cell division
J151_00900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J151_00901	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J151_00902	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J151_00904	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J151_00905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J151_00906	COG1181	Belongs to the D-alanine--D-alanine ligase family
J151_00907	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J151_00910	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
J151_00912	COG0739	heme binding
J151_00913	COG0653	protein targeting
J151_00914	COG0494	nUDIX hydrolase
J151_00916	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J151_00919	COG0604	alcohol dehydrogenase
J151_00919	COG1028	Short-chain dehydrogenase reductase Sdr
J151_00919	COG3321	synthase
J151_00923	COG0366	Alpha amylase catalytic
J151_00929	COG2226	methyltransferase
J151_00930	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J151_00933	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
J151_00939	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J151_00941	COG4106	trans-aconitate 2-methyltransferase activity
J151_00942	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J151_00945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J151_00946	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
J151_00947	COG0667	Aldo Keto reductase
J151_00949	COG4771	TonB-dependent receptor
J151_00954	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J151_00955	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
J151_00957	COG2175	clavaminate synthase activity
J151_00959	COG4181	ATPase activity
J151_00962	COG0642	Histidine kinase
J151_00964	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J151_00968	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J151_00969	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J151_00972	COG3829	transcription factor binding
J151_00974	COG1116	anion transmembrane transporter activity
J151_00975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J151_00977	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J151_00978	COG0431	NADPH-dependent FMN reductase
J151_00983	COG0747	negative chemotaxis
J151_00988	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J151_00989	COG2967	ApaG domain
J151_00990	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J151_00991	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
J151_00992	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J151_00993	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
J151_00996	COG0123	including yeast histone deacetylase and acetoin utilization protein
J151_00997	COG2096	Adenosyltransferase
J151_00999	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J151_01000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J151_01006	COG3384	dioxygenase
J151_01007	COG0583	DNA-binding transcription factor activity
J151_01010	COG1024	Enoyl-CoA hydratase
J151_01014	COG3386	PFAM SMP-30 Gluconolaconase
J151_01016	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
J151_01019	COG0697	spore germination
J151_01020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J151_01023	COG3706	GGDEF domain
J151_01023	COG0745	RESPONSE REGULATOR receiver
J151_01024	COG2205	protein histidine kinase activity
J151_01024	COG0784	Response regulator, receiver
J151_01024	COG5002	protein histidine kinase activity
J151_01025	COG2197	response regulator
J151_01027	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J151_01029	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J151_01030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J151_01031	COG0583	DNA-binding transcription factor activity
J151_01032	COG3634	alkyl hydroperoxide reductase activity
J151_01034	COG2890	protein-(glutamine-N5) methyltransferase activity
J151_01038	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J151_01038	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J151_01044	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J151_01049	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J151_01050	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
J151_01053	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J151_01054	COG1404	Belongs to the peptidase S8 family
J151_01055	COG1404	Belongs to the peptidase S8 family
J151_01056	COG1404	Belongs to the peptidase S8 family
J151_01057	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J151_01063	COG1295	ribonuclease BN
J151_01064	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J151_01065	COG1254	Belongs to the acylphosphatase family
J151_01068	COG0521	Mo-molybdopterin cofactor biosynthetic process
J151_01070	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J151_01071	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
J151_01073	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
J151_01074	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J151_01076	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J151_01077	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J151_01078	COG0193	aminoacyl-tRNA hydrolase activity
J151_01079	COG0012	GTP binding
J151_01083	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J151_01085	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J151_01086	COG0250	Participates in transcription elongation, termination and antitermination
J151_01087	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J151_01088	COG0081	regulation of translation
J151_01089	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J151_01090	COG0222	ribosome binding
J151_01092	COG0085	RNA polymerase activity
J151_01093	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J151_01094	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J151_01095	COG0049	tRNA binding
J151_01096	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J151_01097	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J151_01098	COG0051	transcription antitermination factor activity, RNA binding
J151_01099	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J151_01100	COG0088	Forms part of the polypeptide exit tunnel
J151_01101	COG0089	rRNA binding
J151_01102	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J151_01103	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J151_01104	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J151_01105	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J151_01106	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J151_01107	COG0255	Belongs to the universal ribosomal protein uL29 family
J151_01108	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J151_01109	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J151_01110	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J151_01111	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J151_01112	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J151_01113	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J151_01114	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J151_01115	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J151_01116	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J151_01117	COG1841	ribosomal large subunit assembly
J151_01118	COG0200	Binds to the 23S rRNA
J151_01119	COG0201	protein transport
J151_01120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J151_01121	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J151_01122	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J151_01123	COG0202	RNA polymerase activity
J151_01124	COG0203	ribosomal protein L17
J151_01125	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
J151_01127	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
J151_01129	COG0154	amidase activity
J151_01132	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J151_01133	COG0039	L-malate dehydrogenase activity
J151_01134	COG0625	glutathione transferase activity
J151_01136	COG1902	pentaerythritol trinitrate reductase activity
J151_01136	COG0446	pyridine nucleotide-disulphide oxidoreductase
J151_01137	COG0604	alcohol dehydrogenase
J151_01142	COG0156	8-amino-7-oxononanoate synthase activity
J151_01143	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
J151_01144	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
J151_01145	COG4208	sulfate ABC transporter
J151_01146	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J151_01148	COG1063	alcohol dehydrogenase
J151_01153	COG0406	alpha-ribazole phosphatase activity
J151_01154	COG0285	dihydrofolate synthase activity
J151_01158	COG2833	Protein of unknown function (DUF455)
J151_01160	COG3291	Pkd domain containing protein
J151_01162	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J151_01164	COG0671	phosphoesterase, PA-phosphatase related
J151_01165	COG0438	transferase activity, transferring glycosyl groups
J151_01167	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J151_01170	COG4783	chaperone-mediated protein folding
J151_01173	COG0473	3-isopropylmalate dehydrogenase activity
J151_01180	COG2963	transposase activity
J151_01203	COG2963	transposase activity
J151_01207	COG3852	Histidine kinase
J151_01210	COG0544	peptidyl-prolyl cis-trans isomerase activity
J151_01211	COG0740	serine-type endopeptidase activity
J151_01212	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J151_01218	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J151_01221	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J151_01223	COG0328	RNA-DNA hybrid ribonuclease activity
J151_01224	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J151_01225	COG0631	protein serine/threonine phosphatase activity
J151_01228	COG0859	PFAM glycosyl transferase family 9
J151_01229	COG3642	lipopolysaccharide core region biosynthetic process
J151_01230	COG1234	tRNA 3'-trailer cleavage
J151_01231	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J151_01232	COG0315	cyclic pyranopterin monophosphate synthase activity
J151_01233	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
J151_01234	COG0314	molybdopterin synthase activity
J151_01237	COG2963	transposase activity
J151_01245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
J151_01246	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J151_01247	COG0537	adenosine 5'-monophosphoramidase activity
J151_01251	COG0714	Associated with various cellular activities
J151_01255	COG0424	maF-like protein
J151_01256	COG1399	metal-binding, possibly nucleic acid-binding protein
J151_01257	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J151_01258	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J151_01261	COG1028	Short-chain dehydrogenase reductase Sdr
J151_01262	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J151_01264	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J151_01265	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J151_01270	COG3829	transcription factor binding
J151_01274	COG3609	addiction module antidote protein, CC2985 family
J151_01279	COG2373	Large extracellular alpha-helical protein
J151_01282	COG4953	penicillin-binding protein 1C
J151_01284	COG0678	peroxiredoxin activity
J151_01290	COG0330	HflC and HflK could
J151_01291	COG0330	HflC and HflK could
J151_01293	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J151_01294	COG0308	aminopeptidase N
J151_01296	COG1028	Short-chain dehydrogenase reductase Sdr
J151_01297	COG1309	transcriptional regulator
J151_01310	COG0328	RNA-DNA hybrid ribonuclease activity
J151_01310	COG0406	alpha-ribazole phosphatase activity
J151_01311	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J151_01313	COG3387	PFAM Glycoside hydrolase 15-related
J151_01314	COG1028	Short-chain dehydrogenase reductase Sdr
J151_01315	COG3537	Alpha-1,2-mannosidase
J151_01319	COG0492	ferredoxin-NADP+ reductase activity
J151_01324	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J151_01325	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J151_01326	COG2080	2 iron, 2 sulfur cluster binding
J151_01333	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J151_01336	COG0587	DNA-directed DNA polymerase activity
J151_01339	COG1297	OPT oligopeptide transporter protein
J151_01342	COG1506	peptidase
J151_01342	COG0823	Involved in the tonB-independent uptake of proteins
J151_01345	COG2207	Transcriptional regulator
J151_01345	COG1917	Cupin 2, conserved barrel domain protein
J151_01350	COG0753	catalase activity
J151_01351	COG0656	L-ascorbic acid biosynthetic process
J151_01353	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J151_01353	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J151_01356	COG2814	Major facilitator Superfamily
J151_01359	COG2194	sulfuric ester hydrolase activity
J151_01362	COG0745	RESPONSE REGULATOR receiver
J151_01363	COG0642	Histidine kinase
J151_01365	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
J151_01366	COG2894	cell division
J151_01367	COG0850	regulation of cytokinetic process
J151_01369	COG4585	Histidine kinase
J151_01370	COG2197	response regulator
J151_01373	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
J151_01378	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
J151_01380	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
J151_01385	COG1946	Acyl-CoA thioesterase
J151_01388	COG0824	Thioesterase
J151_01389	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J151_01390	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J151_01391	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J151_01392	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J151_01393	COG0268	Binds directly to 16S ribosomal RNA
J151_01395	COG0196	riboflavin kinase activity
J151_01396	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J151_01397	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J151_01398	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J151_01401	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J151_01402	COG1845	cytochrome c oxidase, subunit III
J151_01403	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
J151_01406	COG3152	Membrane
J151_01408	COG2207	Transcriptional regulator
J151_01409	COG0326	Molecular chaperone. Has ATPase activity
J151_01411	COG1366	Belongs to the anti-sigma-factor antagonist family
J151_01412	COG1366	Belongs to the anti-sigma-factor antagonist family
J151_01413	COG2172	sigma factor antagonist activity
J151_01418	COG4771	TonB-dependent receptor
J151_01420	COG5507	3-demethylubiquinone-9 3-methyltransferase
J151_01421	COG2205	protein histidine kinase activity
J151_01423	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J151_01424	COG3437	response regulator, receiver
J151_01424	COG2205	protein histidine kinase activity
J151_01424	COG4999	Histidine kinase
J151_01424	COG3850	Histidine kinase
J151_01425	COG4191	Histidine kinase
J151_01425	COG0784	Response regulator, receiver
J151_01430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J151_01431	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J151_01433	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J151_01434	COG0228	four-way junction DNA binding
J151_01435	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J151_01436	COG0336	Belongs to the RNA methyltransferase TrmD family
J151_01437	COG0335	large ribosomal subunit rRNA binding
J151_01438	COG0534	Mate efflux family protein
J151_01439	COG0534	Mate efflux family protein
J151_01443	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
J151_01445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J151_01448	COG3209	COG3209 Rhs family protein
J151_01452	COG3250	beta-galactosidase activity
J151_01453	COG3867	Arabinogalactan endo-beta-1,4-galactanase
J151_01457	COG1960	acyl-CoA dehydrogenase activity
J151_01458	COG1024	Enoyl-CoA hydratase
J151_01462	COG1024	Enoyl-CoA hydratase
J151_01462	COG1250	3-hydroxyacyl-CoA dehydrogenase
J151_01465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J151_01466	COG0481	GTPase activity
J151_01469	COG0571	ribonuclease III activity
J151_01470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J151_01471	COG1381	Involved in DNA repair and RecF pathway recombination
J151_01473	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J151_01475	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J151_01476	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
J151_01477	COG3046	protein related to deoxyribodipyrimidine photolyase
J151_01478	COG1472	Belongs to the glycosyl hydrolase 3 family
J151_01480	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
J151_01481	COG1278	Cold shock
J151_01482	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J151_01484	COG1201	RNA secondary structure unwinding
J151_01485	COG1793	dna ligase
J151_01487	COG1793	dna ligase
J151_01487	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J151_01490	COG3706	GGDEF domain
J151_01490	COG0745	RESPONSE REGULATOR receiver
J151_01493	COG0183	Belongs to the thiolase family
J151_01497	COG1451	nucleotide metabolic process
J151_01498	COG5487	UPF0391 membrane protein
J151_01500	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J151_01503	COG1077	Cell shape determining protein MreB Mrl
J151_01504	COG1047	Peptidyl-prolyl cis-trans
J151_01506	COG2824	Alkylphosphonate utilization operon protein PhnA
J151_01507	COG1902	pentaerythritol trinitrate reductase activity
J151_01508	COG2814	Major facilitator Superfamily
J151_01515	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
J151_01515	COG0392	lysyltransferase activity
J151_01518	COG0251	oxidation-reduction process
J151_01519	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J151_01522	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J151_01527	COG1595	DNA-templated transcription, initiation
J151_01530	COG2878	Part of a membrane complex involved in electron transport
J151_01532	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J151_01532	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J151_01535	COG1131	(ABC) transporter
J151_01536	COG0346	lactoylglutathione lyase activity
J151_01537	COG0833	amino acid
J151_01538	COG2040	homocysteine
J151_01540	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J151_01544	COG1695	Transcriptional regulator
J151_01551	COG0825	malonyl-CoA metabolic process
J151_01553	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J151_01554	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J151_01555	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J151_01556	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J151_01557	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J151_01560	COG0750	zinc metalloprotease
J151_01561	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J151_01562	COG0575	Belongs to the CDS family
J151_01563	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J151_01564	COG0233	cytoplasmic translational termination
J151_01565	COG0528	UMP kinase activity
J151_01566	COG0745	RESPONSE REGULATOR receiver
J151_01566	COG3706	GGDEF domain
J151_01567	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J151_01568	COG0052	Belongs to the universal ribosomal protein uS2 family
J151_01575	COG0024	Methionine aminopeptidase
J151_01576	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
J151_01578	COG1393	Belongs to the ArsC family
J151_01579	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J151_01580	COG0367	asparagine synthase
J151_01582	COG4774	siderophore transport
J151_01586	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J151_01592	COG1566	PFAM secretion protein HlyD family protein
J151_01593	COG2814	Major facilitator Superfamily
J151_01597	COG3104	oligopeptide transport
J151_01603	COG0339	signal peptide processing
J151_01604	COG0386	Belongs to the glutathione peroxidase family
J151_01615	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J151_01616	COG0084	hydrolase, TatD family'
J151_01619	COG1960	acyl-CoA dehydrogenase activity
J151_01622	COG0367	asparagine synthase
J151_01624	COG0305	Participates in initiation and elongation during chromosome replication
J151_01625	COG0415	Belongs to the DNA photolyase family
J151_01628	COG0583	DNA-binding transcription factor activity
J151_01635	COG3706	GGDEF domain
J151_01637	COG3706	GGDEF domain
J151_01664	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J151_01667	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J151_01669	COG0497	DNA recombination
J151_01670	COG1420	regulation of RNA biosynthetic process
J151_01671	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J151_01672	COG0443	Heat shock 70 kDa protein
J151_01673	COG0484	heat shock protein binding
J151_01675	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
J151_01681	COG0583	DNA-binding transcription factor activity
J151_01682	COG1132	(ABC) transporter
J151_01689	COG2850	peptidyl-arginine hydroxylation
J151_01693	COG1253	flavin adenine dinucleotide binding
J151_01699	COG1131	(ABC) transporter
J151_01700	COG1725	Transcriptional regulator
J151_01702	COG0386	Belongs to the glutathione peroxidase family
J151_01705	COG2900	Belongs to the SlyX family
J151_01710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J151_01712	COG0646	methionine synthase
J151_01712	COG1410	methionine synthase
J151_01713	COG0646	methionine synthase
J151_01713	COG1410	methionine synthase
J151_01715	COG1960	acyl-CoA dehydrogenase activity
J151_01718	COG0557	exoribonuclease II activity
J151_01720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J151_01721	COG3706	GGDEF domain
J151_01722	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J151_01724	COG0704	Plays a role in the regulation of phosphate uptake
J151_01725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J151_01726	COG0581	inorganic phosphate transmembrane transporter activity
J151_01727	COG0573	inorganic phosphate transmembrane transporter activity
J151_01728	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J151_01733	COG0659	secondary active sulfate transmembrane transporter activity
J151_01734	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J151_01736	COG1024	Enoyl-CoA hydratase
J151_01738	COG0494	nUDIX hydrolase
J151_01746	COG0116	Belongs to the methyltransferase superfamily
J151_01746	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J151_01747	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J151_01751	COG2925	Exonuclease
J151_01752	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J151_01753	COG3844	kynureninase activity
J151_01755	COG0662	Cupin 2, conserved barrel domain protein
J151_01756	COG0288	reversible hydration of carbon dioxide
J151_01768	COG2808	Putative FMN-binding domain
J151_01772	COG0017	Asparaginyl-tRNA synthetase
J151_01773	COG0316	Belongs to the HesB IscA family
J151_01774	COG0360	Binds together with S18 to 16S ribosomal RNA
J151_01775	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J151_01776	COG0359	binds to the 23S rRNA
J151_01778	COG3115	cell septum assembly
J151_01780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J151_01781	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J151_01782	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
J151_01784	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
J151_01786	COG4993	Dehydrogenase
J151_01788	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
J151_01790	COG2986	histidine ammonia-lyase
J151_01791	COG1228	amidohydrolase
J151_01799	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
J151_01800	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J151_01801	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
J151_01802	COG1605	Chorismate mutase
J151_01802	COG0077	Prephenate dehydratase
J151_01803	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J151_01806	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J151_01807	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J151_01808	COG0583	DNA-binding transcription factor activity
J151_01813	COG2963	transposase activity
J151_01819	COG0840	transmembrane signaling receptor activity
J151_01823	COG0745	RESPONSE REGULATOR receiver
J151_01824	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
J151_01825	COG4191	Histidine kinase
J151_01825	COG0784	Response regulator, receiver
J151_01828	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J151_01830	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
J151_01832	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J151_01835	COG1595	DNA-templated transcription, initiation
J151_01846	COG2244	polysaccharide biosynthetic process
J151_01852	COG2264	protein methyltransferase activity
J151_01854	COG0438	transferase activity, transferring glycosyl groups
J151_01857	COG1136	(ABC) transporter
J151_01859	COG0477	Major facilitator Superfamily
J151_01860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J151_01863	COG1253	flavin adenine dinucleotide binding
J151_01865	COG0306	phosphate transporter
J151_01870	COG0504	CTP synthase activity
J151_01871	COG2877	3-deoxy-8-phosphooctulonate synthase activity
J151_01873	COG0148	phosphopyruvate hydratase activity
J151_01874	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
J151_01875	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J151_01876	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J151_01877	COG0585	pseudouridine synthase activity
J151_01878	COG2840	Smr protein MutS2
J151_01879	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
J151_01880	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J151_01881	COG1238	metal cluster binding
J151_01885	COG1534	Rna-binding protein
J151_01886	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
J151_01887	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J151_01888	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J151_01889	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J151_01890	COG1923	regulation of RNA biosynthetic process
J151_01891	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J151_01892	COG1546	Belongs to the CinA family
J151_01894	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J151_01895	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J151_01896	COG2137	regulation of response to DNA damage stimulus
J151_01897	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J151_01898	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
J151_01901	COG1741	Belongs to the pirin family
J151_01902	COG0583	DNA-binding transcription factor activity
J151_01907	COG0351	phosphomethylpyrimidine kinase
J151_01907	COG0352	thiamine-phosphate diphosphorylase activity
J151_01910	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
J151_01911	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J151_01914	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J151_01916	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
J151_01917	COG3734	2-keto-3-deoxy-galactonokinase
J151_01919	COG4948	Mandelate Racemase Muconate Lactonizing
J151_01920	COG0800	Aldolase
J151_01928	COG1501	Belongs to the glycosyl hydrolase 31 family
J151_01930	COG1070	Carbohydrate kinase
J151_01931	COG2115	Belongs to the xylose isomerase family
J151_01932	COG0477	Major facilitator Superfamily
J151_01935	COG0860	N-Acetylmuramoyl-L-alanine amidase
J151_01936	COG1469	GTP cyclohydrolase I activity
J151_01942	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J151_01943	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
J151_01944	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
J151_01945	COG0166	Belongs to the GPI family
J151_01949	COG1472	Belongs to the glycosyl hydrolase 3 family
J151_01951	COG2203	Gaf domain
J151_01951	COG3706	GGDEF domain
J151_01951	COG4251	negative regulation of phosphorylation
J151_01951	COG5001	Diguanylate cyclase
J151_01952	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J151_01953	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
J151_01955	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J151_01956	COG0671	phosphoesterase, PA-phosphatase related
J151_01958	COG1794	racemase activity, acting on amino acids and derivatives
J151_01959	COG0697	spore germination
J151_01960	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J151_01961	COG0167	dihydroorotate dehydrogenase activity
J151_01964	COG1012	belongs to the aldehyde dehydrogenase family
J151_01967	COG1215	transferase activity, transferring glycosyl groups
J151_01968	COG0726	polysaccharide deacetylase
J151_01968	COG1649	PFAM Uncharacterised BCR, COG1649
J151_01971	COG3210	domain, Protein
J151_01972	COG3210	domain, Protein
J151_01981	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J151_01982	COG0124	histidyl-tRNA synthetase
J151_01984	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J151_01985	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J151_01986	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J151_01987	COG0131	Imidazoleglycerol-phosphate dehydratase
J151_01987	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
J151_01988	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J151_01989	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J151_01990	COG0107	imidazoleglycerol-phosphate synthase activity
J151_01991	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J151_01991	COG0140	phosphoribosyl-ATP diphosphatase activity
J151_01994	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
J151_01995	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
J151_01996	COG0235	Class ii aldolase
J151_01997	COG0531	amino acid
J151_01998	COG0531	amino acid
J151_02000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J151_02001	COG0277	FAD linked oxidase domain protein
J151_02005	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J151_02014	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J151_02015	COG2258	MOSC domain
J151_02016	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J151_02017	COG0505	Belongs to the CarA family
J151_02019	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J151_02020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J151_02022	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J151_02030	COG3279	Response regulator of the LytR AlgR family
J151_02031	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
J151_02032	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J151_02034	COG2205	protein histidine kinase activity
J151_02034	COG2198	Histidine kinase
J151_02034	COG0784	Response regulator, receiver
J151_02035	COG1024	Enoyl-CoA hydratase
J151_02036	COG0318	PFAM AMP-dependent synthetase and ligase
J151_02042	COG2267	carboxylic ester hydrolase activity
J151_02044	COG2201	protein-glutamate methylesterase activity
J151_02045	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
J151_02047	COG0840	transmembrane signaling receptor activity
J151_02048	COG0840	transmembrane signaling receptor activity
J151_02049	COG0840	transmembrane signaling receptor activity
J151_02050	COG0840	transmembrane signaling receptor activity
J151_02051	COG0840	transmembrane signaling receptor activity
J151_02052	COG0840	transmembrane signaling receptor activity
J151_02053	COG0840	transmembrane signaling receptor activity
J151_02055	COG0840	transmembrane signaling receptor activity
J151_02056	COG0840	transmembrane signaling receptor activity
J151_02056	COG0840	transmembrane signaling receptor activity
J151_02058	COG0840	transmembrane signaling receptor activity
J151_02059	COG0643	Histidine kinase
J151_02059	COG2198	Histidine kinase
J151_02060	COG0745	RESPONSE REGULATOR receiver
J151_02062	COG0835	chemotaxis
J151_02063	COG1192	Involved in chromosome partitioning
J151_02064	COG1360	Flagellar Motor Protein
J151_02065	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
J151_02078	COG2963	transposase activity
J151_02084	COG0641	radical SAM
J151_02087	COG2198	Histidine kinase
J151_02087	COG0643	Histidine kinase
J151_02091	COG0455	bacterial-type flagellum organization
J151_02093	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J151_02096	COG5001	Diguanylate cyclase
J151_02096	COG3300	MHYT domain
J151_02097	COG5001	Diguanylate cyclase
J151_02097	COG3300	MHYT domain
J151_02098	COG1684	flagellar biosynthetic protein fliR
J151_02099	COG1987	bacterial-type flagellum assembly
J151_02102	COG3190	flagellar
J151_02112	COG1677	Flagellar hook-basal body complex protein FliE
J151_02119	COG1028	Short-chain dehydrogenase reductase Sdr
J151_02120	COG1028	Short-chain dehydrogenase reductase Sdr
J151_02121	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J151_02124	COG2204	response regulator
J151_02125	COG2201	protein-glutamate methylesterase activity
J151_02131	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
J151_02132	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J151_02133	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J151_02135	COG1705	Flagellar rod assembly protein muramidase FlgJ
J151_02135	COG3951	Flagellar rod assembly protein muramidase FlgJ
J151_02136	COG1706	bacterial-type flagellum-dependent cell motility
J151_02137	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
J151_02138	COG4786	Flagellar basal body rod
J151_02139	COG4787	bacterial-type flagellum-dependent cell motility
J151_02140	COG1749	Flagellar hook protein flgE
J151_02141	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
J151_02142	COG1558	bacterial-type flagellum-dependent cell motility
J151_02144	COG0835	chemotaxis
J151_02144	COG0784	Response regulator, receiver
J151_02148	COG5002	protein histidine kinase activity
J151_02154	COG2915	High frequency lysogenization protein hflD homolog
J151_02155	COG0482	sulfurtransferase activity
J151_02157	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
J151_02158	COG0542	response to heat
J151_02159	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J151_02160	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
J151_02162	COG0492	ferredoxin-NADP+ reductase activity
J151_02163	COG1674	ftsk spoiiie
J151_02165	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
J151_02167	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J151_02169	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J151_02171	COG0183	Belongs to the thiolase family
J151_02172	COG1250	3-hydroxyacyl-CoA dehydrogenase
J151_02172	COG1024	Enoyl-CoA hydratase
J151_02174	COG0105	UTP biosynthetic process
J151_02175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J151_02177	COG1426	Protein conserved in bacteria
J151_02179	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J151_02180	COG1160	GTP binding
J151_02181	COG0303	'Molybdopterin
J151_02182	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J151_02189	COG0708	Exodeoxyribonuclease III
J151_02191	COG0303	'Molybdopterin
J151_02192	COG0746	molybdenum cofactor guanylyltransferase activity
J151_02195	COG1914	H( )-stimulated, divalent metal cation uptake system
J151_02196	COG1321	iron dependent repressor
J151_02197	COG0590	tRNA wobble adenosine to inosine editing
J151_02198	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
J151_02199	COG0668	transmembrane transport
J151_02201	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
J151_02204	COG1028	Short-chain dehydrogenase reductase Sdr
J151_02205	COG1183	phosphatidylcholine synthase activity
J151_02207	COG3243	poly(R)-hydroxyalkanoic acid synthase
J151_02210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J151_02210	COG0723	plastoquinol--plastocyanin reductase activity
J151_02212	COG2183	response to ionizing radiation
J151_02213	COG2205	protein histidine kinase activity
J151_02213	COG0784	Response regulator, receiver
J151_02226	COG0800	Aldolase
J151_02227	COG0129	dihydroxy-acid dehydratase activity
J151_02228	COG0363	glucosamine-6-phosphate deaminase activity
J151_02229	COG0837	glucose binding
J151_02230	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J151_02235	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
J151_02238	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J151_02239	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
J151_02241	COG4591	ABC-type transport system involved in lipoprotein release permease component
J151_02242	COG1136	(ABC) transporter
J151_02245	COG0811	peptide transport
J151_02247	COG1132	(ABC) transporter
J151_02248	COG1663	tetraacyldisaccharide 4'-kinase activity
J151_02249	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
J151_02250	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J151_02252	COG0322	excinuclease ABC activity
J151_02253	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J151_02257	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J151_02258	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J151_02262	COG2963	transposase activity
J151_02263	COG0582	viral genome integration into host DNA
J151_02265	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
J151_02271	COG1530	ribonuclease E activity
J151_02273	COG3064	Membrane
J151_02274	COG0428	transporter
J151_02276	COG2154	pterin-4-alpha-carbinolamine dehydratase
J151_02277	COG0316	Belongs to the HesB IscA family
J151_02277	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
J151_02288	COG1028	Short-chain dehydrogenase reductase Sdr
J151_02293	COG2963	transposase activity
J151_02295	COG1238	metal cluster binding
J151_02301	COG3279	Response regulator of the LytR AlgR family
J151_02309	COG4566	intracellular signal transduction
J151_02311	COG5001	Diguanylate cyclase
J151_02314	COG3685	Protein conserved in bacteria
J151_02318	COG1648	precorrin-2 dehydrogenase activity
J151_02318	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J151_02321	COG2814	Major facilitator Superfamily
J151_02324	COG1335	isochorismatase
J151_02327	COG2197	response regulator
J151_02330	COG0583	DNA-binding transcription factor activity
J151_02331	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J151_02332	COG3002	Belongs to the UPF0753 family
J151_02334	COG2963	transposase activity
J151_02335	COG1396	sequence-specific DNA binding
J151_02336	COG5489	Protein of unknown function (DUF736)
J151_02337	COG2003	Belongs to the UPF0758 family
J151_02342	COG0582	viral genome integration into host DNA
J151_02345	COG4774	siderophore transport
J151_02349	COG2336	PFAM SpoVT AbrB
J151_02354	COG4206	TonB-dependent receptor
J151_02359	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
J151_02359	COG2273	Hydrolase Family 16
J151_02364	COG2274	protein secretion by the type I secretion system
J151_02366	COG1192	Involved in chromosome partitioning
J151_02374	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J151_02375	COG0270	DNA (cytosine-5-)-methyltransferase activity
J151_02387	COG4804	nuclease activity
J151_02388	COG2963	transposase activity
J151_02390	COG5006	permease, DMT superfamily
J151_02393	COG2249	NAD(P)H dehydrogenase (quinone) activity
J151_02395	COG3938	Belongs to the proline racemase family
J151_02396	COG0655	NAD(P)H dehydrogenase (quinone) activity
J151_02398	COG2807	transmembrane transport
J151_02399	COG2207	Transcriptional regulator
J151_02430	COG0210	DNA helicase
J151_02446	COG2084	Dehydrogenase
J151_02451	COG2003	Belongs to the UPF0758 family
J151_02458	COG0582	viral genome integration into host DNA
J151_02459	COG0519	Catalyzes the synthesis of GMP from XMP
J151_02459	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J151_02461	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J151_02463	COG0475	glutathione-regulated potassium exporter activity
J151_02463	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J151_02464	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J151_02466	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J151_02467	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
J151_02469	COG0776	regulation of translation
J151_02470	COG0539	negative regulation of cytoplasmic translation
J151_02471	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J151_02472	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J151_02475	COG2957	Belongs to the agmatine deiminase family
J151_02476	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J151_02481	COG0395	ABC-type sugar transport system, permease component
J151_02482	COG1175	transmembrane transport
J151_02488	COG2350	Protein conserved in bacteria
J151_02489	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
J151_02490	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J151_02491	COG1187	pseudouridine synthase activity
J151_02495	COG0436	Aminotransferase
J151_02496	COG4133	protoheme IX ABC transporter activity
J151_02500	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
J151_02501	COG1138	Cytochrome C-type biogenesis protein
J151_02505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J151_02506	COG1278	Cold shock
J151_02507	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
J151_02508	COG4988	ABC transporter
J151_02510	COG1294	oxidase, subunit
J151_02515	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J151_02516	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J151_02518	COG0165	Argininosuccinate lyase
J151_02519	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J151_02521	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J151_02524	COG0137	argininosuccinate synthase activity
J151_02525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J151_02527	COG0215	cysteine-tRNA ligase activity
J151_02528	COG2166	iron-sulfur cluster assembly
J151_02530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J151_02531	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J151_02532	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J151_02537	COG4302	ethanolamine ammonia-lyase activity
J151_02543	COG2963	transposase activity
J151_02549	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J151_02550	COG0402	S-adenosylhomocysteine deaminase activity
J151_02552	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J151_02553	COG1509	lysine 2,3-aminomutase activity
J151_02554	COG3300	MHYT domain
J151_02554	COG5001	Diguanylate cyclase
J151_02557	COG0483	inositol monophosphate 1-phosphatase activity
J151_02562	COG0513	Belongs to the DEAD box helicase family
J151_02563	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J151_02564	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
J151_02566	COG0625	glutathione transferase activity
J151_02568	COG4681	YaeQ
J151_02569	COG2081	HI0933 family
J151_02571	COG0501	Belongs to the peptidase M48B family
J151_02572	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J151_02573	COG1028	Short-chain dehydrogenase reductase Sdr
J151_02577	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J151_02578	COG0860	N-Acetylmuramoyl-L-alanine amidase
J151_02579	COG0802	atpase or kinase
J151_02580	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J151_02580	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J151_02581	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J151_02582	COG1570	exodeoxyribonuclease VII activity
J151_02584	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J151_02623	COG0835	chemotaxis
J151_02624	COG0840	transmembrane signaling receptor activity
J151_02625	COG2094	Belongs to the DNA glycosylase MPG family
J151_02626	COG1201	RNA secondary structure unwinding
J151_02629	COG2969	positive regulation of protein catabolic process
J151_02630	COG0625	glutathione transferase activity
J151_02631	COG2857	Cytochrome c1
J151_02632	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J151_02633	COG0723	plastoquinol--plastocyanin reductase activity
J151_02634	COG0741	lytic transglycosylase activity
J151_02637	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J151_02638	COG1702	phosphate starvation-inducible protein PhoH
J151_02640	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J151_02642	COG4535	Mg2 and Co2 transporter CorC
J151_02645	COG1012	belongs to the aldehyde dehydrogenase family
J151_02646	COG1177	transmembrane transport
J151_02647	COG1176	ABC-type spermidine putrescine transport system, permease component I
J151_02648	COG3842	ATPase activity
J151_02652	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
J151_02655	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J151_02656	COG0174	glutamine synthetase
J151_02657	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J151_02658	COG3706	GGDEF domain
J151_02658	COG0745	RESPONSE REGULATOR receiver
J151_02659	COG2703	oxygen carrier activity
J151_02660	COG0477	Major facilitator Superfamily
J151_02662	COG0243	molybdopterin cofactor binding
J151_02663	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
J151_02667	COG2733	membrane
J151_02668	COG0784	Response regulator, receiver
J151_02668	COG2205	protein histidine kinase activity
J151_02668	COG5002	protein histidine kinase activity
J151_02670	COG0477	Major facilitator Superfamily
J151_02671	COG2902	Dehydrogenase
J151_02673	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J151_02674	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J151_02675	COG1609	Transcriptional regulator
J151_02676	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J151_02676	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J151_02677	COG1105	Belongs to the carbohydrate kinase PfkB family
J151_02678	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J151_02678	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J151_02686	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J151_02688	COG1862	Preprotein translocase
J151_02689	COG0343	queuine tRNA-ribosyltransferase activity
J151_02690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
J151_02698	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
J151_02699	COG3291	Pkd domain containing protein
J151_02700	COG0405	Gamma-glutamyltransferase
J151_02701	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J151_02704	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J151_02705	COG0742	ribosomal rna small subunit methyltransferase
J151_02706	COG0326	Molecular chaperone. Has ATPase activity
J151_02722	COG0531	amino acid
J151_02725	COG0006	proline dipeptidase activity
J151_02727	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J151_02730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J151_02731	COG3938	Belongs to the proline racemase family
J151_02733	COG0552	protein localization to endoplasmic reticulum
J151_02734	COG1194	a g-specific adenine glycosylase
J151_02735	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
J151_02736	COG4191	Histidine kinase
J151_02736	COG0784	Response regulator, receiver
J151_02739	COG0322	excinuclease ABC activity
J151_02742	COG3040	lipid binding
J151_02744	COG1960	acyl-CoA dehydrogenase activity
J151_02746	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J151_02750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J151_02751	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J151_02752	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J151_02759	COG0438	transferase activity, transferring glycosyl groups
J151_02760	COG0438	transferase activity, transferring glycosyl groups
J151_02769	COG0776	regulation of translation
J151_02770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J151_02770	COG0072	phenylalanine-tRNA ligase activity
J151_02771	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J151_02772	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J151_02773	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J151_02775	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J151_02776	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J151_02781	COG1082	Xylose isomerase domain protein TIM barrel
J151_02785	COG0366	Alpha amylase catalytic
J151_02787	COG2963	transposase activity
J151_02788	COG2801	Transposase and inactivated derivatives
J151_02801	COG2948	multi-organism process
J151_02805	COG3505	Type IV secretory pathway VirD4
J151_02808	COG0556	nucleotide-excision repair
J151_02816	COG2963	transposase activity
J151_02826	COG4695	Portal protein
J151_02835	COG3179	chitinase
J151_02846	COG2963	transposase activity
J151_02851	COG3275	phosphorelay sensor kinase activity
J151_02852	COG1611	Belongs to the LOG family
J151_02854	COG2095	MarC family integral membrane protein
J151_02856	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J151_02857	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J151_02863	COG1185	polyribonucleotide nucleotidyltransferase activity
J151_02864	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J151_02865	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J151_02866	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J151_02867	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J151_02868	COG0195	Participates in both transcription termination and antitermination
J151_02869	COG0779	Required for maturation of 30S ribosomal subunits
J151_02871	COG1007	ATP synthesis coupled electron transport
J151_02874	COG0713	ATP synthesis coupled electron transport
J151_02876	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J151_02877	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
J151_02879	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J151_02880	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
J151_02881	COG0649	NAD binding
J151_02882	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J151_02883	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J151_02884	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J151_02887	COG0149	triose-phosphate isomerase activity
J151_02888	COG0300	oxidoreductase activity
J151_02894	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J151_02895	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
J151_02896	COG0159	tryptophan synthase activity
J151_02898	COG0133	tryptophan synthase activity
J151_02900	COG0135	phosphoribosylanthranilate isomerase activity
J151_02901	COG0101	tRNA pseudouridine synthase activity
J151_02905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J151_02906	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J151_02907	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J151_02908	COG2890	protein-(glutamine-N5) methyltransferase activity
J151_02910	COG0688	phosphatidylethanolamine metabolic process
J151_02912	COG0433	COG0433 Predicted ATPase
J151_02913	COG0494	nUDIX hydrolase
J151_02916	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J151_02917	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J151_02922	COG0717	Belongs to the dCTP deaminase family
J151_02923	COG0489	protein tyrosine kinase activity
J151_02927	COG3590	peptidase
J151_02928	COG3590	peptidase
J151_02932	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J151_02933	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J151_02934	COG2311	Membrane
J151_02935	COG1047	Peptidyl-prolyl cis-trans
J151_02936	COG0791	NLP P60 protein
J151_02937	COG0791	NLP P60 protein
J151_02939	COG4106	trans-aconitate 2-methyltransferase activity
J151_02940	COG1301	dicarboxylic acid transport
J151_02941	COG1785	Belongs to the alkaline phosphatase family
J151_02942	COG0037	tRNA processing
J151_02943	COG1722	exodeoxyribonuclease VII activity
J151_02944	COG0142	geranyltranstransferase activity
J151_02945	COG4104	PAAR repeat-containing protein
J151_02947	COG0312	modulator of DNA gyrase
J151_02948	COG3028	Belongs to the UPF0307 family
J151_02949	COG0312	modulator of DNA gyrase
J151_02951	COG3164	Protein of unknown function
J151_02952	COG1530	ribonuclease E activity
J151_02953	COG0424	maF-like protein
J151_02954	COG2968	Membrane
J151_02957	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J151_02960	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J151_02963	COG0495	leucyl-tRNA aminoacylation
J151_02965	COG3118	belongs to the thioredoxin family
J151_02970	COG2155	Conserved Protein
J151_02971	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J151_02978	COG1132	(ABC) transporter
J151_02984	COG1538	Outer membrane efflux protein
J151_02985	COG0745	RESPONSE REGULATOR receiver
J151_02986	COG5002	protein histidine kinase activity
J151_02986	COG5000	phosphorelay sensor kinase activity
J151_02987	COG0475	glutathione-regulated potassium exporter activity
J151_02988	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J151_02989	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J151_02992	COG0745	RESPONSE REGULATOR receiver
J151_02992	COG3706	GGDEF domain
J151_02993	COG1187	pseudouridine synthase activity
J151_02994	COG5002	protein histidine kinase activity
J151_02994	COG5001	Diguanylate cyclase
J151_03018	COG0667	Aldo Keto reductase
J151_03019	COG2814	Major facilitator Superfamily
J151_03020	COG0583	DNA-binding transcription factor activity
J151_03022	COG2207	Transcriptional regulator
J151_03024	COG1309	transcriptional regulator
J151_03025	COG1538	Outer membrane efflux protein
J151_03029	COG0735	belongs to the Fur family
J151_03030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J151_03035	COG4452	Inner membrane protein CreD
J151_03037	COG2205	protein histidine kinase activity
J151_03038	COG0745	RESPONSE REGULATOR receiver
J151_03039	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
J151_03041	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J151_03048	COG0643	Histidine kinase
J151_03048	COG2198	Histidine kinase
J151_03049	COG0840	transmembrane signaling receptor activity
J151_03050	COG0835	chemotaxis
J151_03051	COG2199	diguanylate cyclase activity
J151_03051	COG2202	Pas domain
J151_03051	COG2200	EAL domain
J151_03052	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J151_03053	COG2201	protein-glutamate methylesterase activity
J151_03054	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J151_03055	COG3590	peptidase
J151_03057	COG0588	phosphoglycerate mutase activity
J151_03058	COG1515	deoxyribonuclease V activity
J151_03060	COG1741	Belongs to the pirin family
J151_03063	COG1741	Belongs to the pirin family
J151_03064	COG1966	Carbon starvation protein
J151_03065	COG2879	small protein
J151_03076	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
J151_03077	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J151_03078	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J151_03079	COG2080	2 iron, 2 sulfur cluster binding
J151_03081	COG3706	GGDEF domain
J151_03081	COG4251	negative regulation of phosphorylation
J151_03081	COG2203	Gaf domain
J151_03081	COG5001	Diguanylate cyclase
J151_03090	COG0629	single-stranded DNA binding
J151_03091	COG0142	geranyltranstransferase activity
J151_03093	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J151_03096	COG0527	aspartate kinase activity
J151_03097	COG0384	phenazine biosynthesis protein PhzF
J151_03098	COG0384	phenazine biosynthesis protein PhzF
J151_03100	COG1764	response to oxidative stress
J151_03101	COG0540	Belongs to the ATCase OTCase family
J151_03102	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J151_03103	COG1678	Uncharacterized ACR, COG1678
J151_03104	COG0519	Catalyzes the synthesis of GMP from XMP
J151_03107	COG5297	Belongs to the glycosyl hydrolase family 6
J151_03110	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J151_03113	COG0739	heme binding
J151_03117	COG0693	protein deglycase activity
J151_03119	COG1959	2 iron, 2 sulfur cluster binding
J151_03120	COG0719	Fe-S assembly protein
J151_03121	COG0396	ATPase activity
J151_03122	COG0719	Fe-S assembly protein
J151_03123	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J151_03126	COG4774	siderophore transport
J151_03127	COG3128	pkhd-type hydroxylase
J151_03132	COG1477	protein flavinylation
J151_03133	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J151_03136	COG1555	photosystem II stabilization
J151_03137	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J151_03139	COG3178	'Phosphotransferase
J151_03140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J151_03142	COG0628	permease
J151_03144	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J151_03146	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J151_03150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J151_03151	COG0271	Belongs to the BolA IbaG family
J151_03153	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
J151_03155	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
J151_03156	COG1137	ATPase activity
J151_03159	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J151_03160	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
J151_03161	COG1660	Displays ATPase and GTPase activities
J151_03163	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J151_03164	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J151_03165	COG2239	Acts as a magnesium transporter
J151_03167	COG1294	oxidase, subunit
J151_03168	COG1271	oxidase subunit
J151_03170	COG1113	amino acid transport
J151_03173	COG2197	response regulator
J151_03174	COG0531	amino acid
J151_03179	COG1234	tRNA 3'-trailer cleavage
J151_03186	COG2814	Major facilitator Superfamily
J151_03188	COG0754	glutathionylspermidine amidase activity
J151_03193	COG1842	Phage shock protein A
J151_03195	COG0259	pyridoxamine-phosphate oxidase activity
J151_03196	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J151_03197	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J151_03199	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J151_03213	COG2814	Major facilitator Superfamily
J151_03217	COG0784	Response regulator, receiver
J151_03217	COG2198	Histidine kinase
J151_03217	COG2205	protein histidine kinase activity
J151_03218	COG2353	YceI-like domain
J151_03222	COG1760	l-serine dehydratase
J151_03224	COG0527	aspartate kinase activity
J151_03224	COG0460	homoserine dehydrogenase
J151_03225	COG0626	cystathionine gamma-synthase activity
J151_03226	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J151_03228	COG0739	heme binding
J151_03229	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J151_03230	COG1272	protein, Hemolysin III
J151_03231	COG2982	Protein involved in outer membrane biogenesis
J151_03232	COG0516	GMP reductase activity
J151_03232	COG0517	IMP dehydrogenase activity
J151_03233	COG0463	Glycosyl transferase, family 2
J151_03234	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J151_03235	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
J151_03237	COG4771	TonB-dependent receptor
J151_03239	COG1309	transcriptional regulator
J151_03240	COG2267	carboxylic ester hydrolase activity
J151_03241	COG1960	acyl-CoA dehydrogenase activity
J151_03246	COG0509	glycine decarboxylation via glycine cleavage system
J151_03247	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J151_03249	COG0330	HflC and HflK could
J151_03250	COG1742	UPF0060 membrane protein
J151_03251	COG3956	TIGRFAM MazG family protein
J151_03253	COG0494	nUDIX hydrolase
J151_03255	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J151_03256	COG0837	glucose binding
J151_03259	COG3858	chitin binding
J151_03259	COG1388	LysM domain
J151_03260	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J151_03262	COG1472	Belongs to the glycosyl hydrolase 3 family
J151_03265	COG0531	amino acid
J151_03267	COG1486	melibiose metabolic process
J151_03269	COG3537	Alpha-1,2-mannosidase
J151_03276	COG3142	Participates in the control of copper homeostasis
J151_03277	COG1446	asparaginase
J151_03282	COG0840	transmembrane signaling receptor activity
J151_03286	COG0189	ligase activity
J151_03288	COG1397	ADP-ribosylglycohydrolase
J151_03290	COG1199	ATP-dependent helicase activity
J151_03292	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J151_03293	COG1215	transferase activity, transferring glycosyl groups
J151_03295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J151_03296	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
J151_03297	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
J151_03298	COG0535	radical SAM domain protein
J151_03299	COG0535	radical SAM domain protein
J151_03302	COG0837	glucose binding
J151_03304	COG1643	Atp-dependent helicase
J151_03305	COG0783	Belongs to the Dps family
J151_03306	COG0514	ATP-dependent DNA helicase (RecQ)
J151_03313	COG0840	transmembrane signaling receptor activity
J151_03317	COG3920	Histidine kinase
J151_03318	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
J151_03320	COG0602	queuosine metabolic process
J151_03322	COG2885	chlorophyll binding
J151_03323	COG0823	Involved in the tonB-independent uptake of proteins
J151_03325	COG0848	biopolymer transport protein
J151_03327	COG0824	Thioesterase
J151_03328	COG2255	four-way junction helicase activity
J151_03330	COG3158	transport of potassium into the cell
J151_03331	COG0632	four-way junction helicase activity
J151_03332	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J151_03333	COG0217	transcriptional regulatory protein
J151_03336	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J151_03339	COG0477	Major facilitator Superfamily
J151_03347	COG0488	(ABC) transporter
J151_03353	COG4651	solute:proton antiporter activity
J151_03353	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J151_03358	COG4772	TonB-dependent receptor
J151_03360	COG4264	IucA IucC family
J151_03363	COG0019	diaminopimelate decarboxylase activity
J151_03368	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
J151_03370	COG1492	cobalamin metabolic process
J151_03373	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
J151_03377	COG4206	TonB-dependent receptor
J151_03379	COG0542	response to heat
J151_03380	COG1116	anion transmembrane transporter activity
J151_03381	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J151_03382	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J151_03383	COG0667	Aldo Keto reductase
J151_03385	COG4771	TonB-dependent receptor
J151_03386	COG2827	Endonuclease containing a URI domain
J151_03394	COG1877	trehalose-phosphatase activity
J151_03395	COG3387	PFAM Glycoside hydrolase 15-related
J151_03398	COG0840	transmembrane signaling receptor activity
J151_03399	COG3011	Protein conserved in bacteria
J151_03402	COG0564	pseudouridine synthase activity
J151_03403	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J151_03405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J151_03405	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
J151_03407	COG2963	transposase activity
J151_03411	COG2951	lytic endotransglycosylase activity
J151_03412	COG4644	lycopene metabolic process
J151_03416	COG2369	cell adhesion
J151_03421	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
J151_03422	COG0045	succinate-CoA ligase (ADP-forming) activity
J151_03426	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J151_03432	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
J151_03433	COG0237	dephospho-CoA kinase activity
J151_03436	COG2963	transposase activity
J151_03438	COG5002	protein histidine kinase activity
J151_03439	COG0745	RESPONSE REGULATOR receiver
J151_03441	COG0189	ligase activity
J151_03455	COG2003	Belongs to the UPF0758 family
J151_03460	COG4191	Histidine kinase
J151_03460	COG0784	Response regulator, receiver
J151_03461	COG0784	Response regulator, receiver
J151_03461	COG4191	Histidine kinase
J151_03480	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J151_03486	COG2022	thiamine diphosphate biosynthetic process
J151_03487	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J151_03488	COG0471	metal ion transport
J151_03488	COG3273	potassium ion transport
J151_03492	COG1970	mechanosensitive ion channel activity
J151_03496	COG3250	beta-galactosidase activity
J151_03497	COG4948	Mandelate Racemase Muconate Lactonizing
J151_03500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J151_03502	COG0308	aminopeptidase N
J151_03505	COG2963	transposase activity
J151_03511	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J151_03513	COG0529	Catalyzes the synthesis of activated sulfate
J151_03513	COG2895	sulfate adenylyltransferase (ATP) activity
J151_03514	COG0175	sulfate reduction
J151_03515	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J151_03516	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J151_03517	COG0175	sulfate reduction
J151_03524	COG1648	precorrin-2 dehydrogenase activity
J151_03524	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J151_03527	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
J151_03528	COG3588	fructose-bisphosphate aldolase
J151_03529	COG0469	pyruvate kinase activity
J151_03531	COG0126	phosphoglycerate kinase activity
J151_03536	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J151_03538	COG3047	cAMP biosynthetic process
J151_03539	COG3047	cAMP biosynthetic process
J151_03541	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J151_03541	COG3453	Protein conserved in bacteria
J151_03542	COG0725	ABC transporter, periplasmic molybdate-binding protein
J151_03543	COG4149	molybdate abc transporter
J151_03544	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
J151_03551	COG1376	ErfK ybiS ycfS ynhG family protein
J151_03552	COG0739	heme binding
J151_03554	COG4773	Receptor
J151_03555	COG0596	Alpha beta hydrolase
J151_03556	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
J151_03557	COG1301	dicarboxylic acid transport
J151_03559	COG2304	oxidoreductase activity
J151_03563	COG0714	Associated with various cellular activities
J151_03570	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J151_03574	COG0254	rRNA binding
J151_03576	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J151_03578	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J151_03579	COG1758	RNA polymerase activity
J151_03580	COG0194	GDP metabolic process
J151_03581	COG1561	YicC-like family, N-terminal region
J151_03582	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J151_03584	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J151_03585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J151_03588	COG0006	proline dipeptidase activity
J151_03590	COG0006	proline dipeptidase activity
J151_03591	COG3079	Belongs to the UPF0149 family
J151_03595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J151_03597	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
J151_03599	COG2912	Transglutaminase-like superfamily
J151_03600	COG1773	rubredoxin
J151_03601	COG0352	thiamine-phosphate diphosphorylase activity
J151_03604	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J151_03607	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J151_03613	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J151_03614	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J151_03615	COG1028	Short-chain dehydrogenase reductase Sdr
J151_03617	COG0671	phosphoesterase, PA-phosphatase related
J151_03618	COG3781	membrane
J151_03620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J151_03621	COG0563	adenylate kinase activity
J151_03624	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
J151_03626	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
J151_03630	COG0823	Involved in the tonB-independent uptake of proteins
J151_03631	COG3710	Transcriptional regulator
J151_03632	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
J151_03635	COG0840	transmembrane signaling receptor activity
J151_03636	COG0405	Gamma-glutamyltransferase
J151_03637	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J151_03641	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J151_03642	COG0473	3-isopropylmalate dehydrogenase activity
J151_03643	COG0066	3-isopropylmalate dehydratase activity
J151_03644	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J151_03648	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J151_03649	COG1538	Outer membrane efflux protein
J151_03650	COG1519	Transferase
J151_03651	COG1560	Kdo2-lipid A biosynthetic process
J151_03656	COG0281	malic enzyme
J151_03656	COG0280	phosphate acetyltransferase
J151_03657	COG1301	dicarboxylic acid transport
J151_03662	COG0583	DNA-binding transcription factor activity
J151_03663	COG0667	Aldo Keto reductase
J151_03667	COG2197	response regulator
J151_03668	COG1840	ABC-type Fe3 transport system, periplasmic component
J151_03669	COG0642	Histidine kinase
J151_03672	COG2851	Citrate transporter
J151_03674	COG1028	Short-chain dehydrogenase reductase Sdr
J151_03675	COG1609	Transcriptional regulator
J151_03676	COG2211	Major facilitator Superfamily
J151_03681	COG1162	GTPase activity
J151_03685	COG4773	Receptor
J151_03686	COG0726	polysaccharide deacetylase
J151_03687	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J151_03690	COG2963	transposase activity
J151_03691	COG2801	Transposase and inactivated derivatives
J151_03695	COG1307	EDD domain protein, DegV family
J151_03696	COG0242	peptide deformylase activity
J151_03700	COG0457	Tetratricopeptide repeat
J151_03701	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
J151_03702	COG1215	transferase activity, transferring glycosyl groups
J151_03703	COG1215	transferase activity, transferring glycosyl groups
J151_03707	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
J151_03717	COG2188	Transcriptional regulator
J151_03719	COG1450	Type ii and iii secretion system protein
J151_03722	COG3166	PFAM Fimbrial assembly family protein
J151_03723	COG3156	type II secretion system protein K
J151_03724	COG4795	General secretion pathway protein
J151_03725	COG2165	general secretion pathway protein
J151_03726	COG4970	Tfp pilus assembly protein FimT
J151_03727	COG2165	general secretion pathway protein
J151_03728	COG1459	type II secretion system
J151_03729	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J151_03730	COG1404	Belongs to the peptidase S8 family
J151_03731	COG5295	Hep Hag repeat protein
J151_03732	COG1404	Belongs to the peptidase S8 family
J151_03733	COG5295	Hep Hag repeat protein
J151_03734	COG0047	phosphoribosylformylglycinamidine synthase activity
J151_03734	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J151_03735	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J151_03736	COG4974	Belongs to the 'phage' integrase family
J151_03739	COG0795	lipopolysaccharide-transporting ATPase activity
J151_03741	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J151_03744	COG0525	valine-tRNA ligase activity
J151_03750	COG1183	phosphatidylcholine synthase activity
J151_03752	COG0442	prolyl-tRNA aminoacylation
J151_03755	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J151_03756	COG1127	ABC transporter
J151_03757	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J151_03757	COG3218	ABC-type transport auxiliary lipoprotein component
J151_03764	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J151_03765	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
J151_03765	COG0662	Cupin 2, conserved barrel domain protein
J151_03771	COG2086	electron transfer activity
J151_03774	COG0546	phosphoglycolate phosphatase activity
J151_03774	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J151_03775	COG0277	FAD linked oxidase domain protein
J151_03778	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J151_03784	COG1216	Glycosyl transferase, family 2
J151_03784	COG0438	transferase activity, transferring glycosyl groups
J151_03788	COG0626	cystathionine gamma-synthase activity
J151_03794	COG0625	glutathione transferase activity
J151_03796	COG0513	Belongs to the DEAD box helicase family
J151_03799	COG4206	TonB-dependent receptor
J151_03800	COG0720	synthase
J151_03802	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
J151_03803	COG1956	GAF domain-containing protein
J151_03805	COG2819	hydrolase of the alpha beta superfamily
J151_03808	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J151_03809	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J151_03812	COG0339	signal peptide processing
J151_03815	COG2132	Multicopper oxidase
J151_03823	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J151_03824	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J151_03825	COG1136	(ABC) transporter
J151_03825	COG4591	ABC-type transport system involved in lipoprotein release permease component
J151_03826	COG1136	(ABC) transporter
J151_03826	COG0577	efflux transmembrane transporter activity
J151_03827	COG0577	efflux transmembrane transporter activity
J151_03829	COG2204	response regulator
J151_03830	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J151_03833	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J151_03834	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J151_03835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J151_03836	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J151_03837	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J151_03838	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J151_03840	COG0356	it plays a direct role in the translocation of protons across the membrane
J151_03844	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J151_03846	COG0508	dehydrogenase complex catalyzes the overall conversion of
J151_03853	COG2011	ABC-type metal ion transport system permease component
J151_03854	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J151_03855	COG0697	spore germination
J151_03856	COG1666	GTP binding
J151_03858	COG5002	protein histidine kinase activity
J151_03858	COG2198	Histidine kinase
J151_03858	COG0784	Response regulator, receiver
J151_03862	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J151_03863	COG1187	pseudouridine synthase activity
J151_03864	COG2813	Specifically methylates the guanine in position
J151_03868	COG2202	Pas domain
J151_03868	COG2205	protein histidine kinase activity
J151_03872	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J151_03873	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J151_03874	COG1522	sequence-specific DNA binding
J151_03884	COG0842	Transport permease protein
J151_03885	COG1131	(ABC) transporter
J151_03886	COG0025	NhaP-type Na H and K H
J151_03887	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
J151_03888	COG1573	uracil-dna glycosylase
J151_03890	COG3384	dioxygenase
J151_03892	COG0583	DNA-binding transcription factor activity
J151_03894	COG0667	Aldo Keto reductase
J151_03896	COG3590	peptidase
J151_03900	COG0531	amino acid
J151_03903	COG2972	Histidine kinase
J151_03906	COG3685	Protein conserved in bacteria
J151_03907	COG3546	catalase activity
J151_03915	COG1271	oxidase subunit
J151_03916	COG1294	oxidase, subunit
J151_03919	COG1028	Short-chain dehydrogenase reductase Sdr
J151_03920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J151_03924	COG1132	(ABC) transporter
J151_03927	COG1063	alcohol dehydrogenase
J151_03942	COG0251	oxidation-reduction process
J151_03948	COG0840	transmembrane signaling receptor activity
J151_03952	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J151_03961	COG0024	Methionine aminopeptidase
J151_03966	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J151_03967	COG1490	D-aminoacyl-tRNA deacylase activity
J151_03968	COG1560	Kdo2-lipid A biosynthetic process
J151_03977	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J151_03977	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J151_03978	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J151_03979	COG0242	peptide deformylase activity
J151_03980	COG1652	LysM domain
J151_03981	COG0758	DNA mediated transformation
J151_03982	COG2922	Belongs to the Smg family
J151_03985	COG1754	DNA topoisomerase type I activity
J151_03985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J151_03986	COG0009	L-threonylcarbamoyladenylate synthase
J151_03989	COG1028	Short-chain dehydrogenase reductase Sdr
J151_03991	COG0616	signal peptide processing
J151_03992	COG0534	Mate efflux family protein
J151_03996	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J151_03997	COG0625	glutathione transferase activity
J151_04000	COG1252	NADH dehydrogenase
J151_04001	COG2860	membrane
J151_04002	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J151_04003	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J151_04004	COG2201	protein-glutamate methylesterase activity
J151_04005	COG2177	Part of the ABC transporter FtsEX involved in
J151_04006	COG2884	Cell division ATP-binding protein ftsE
J151_04007	COG0513	Belongs to the DEAD box helicase family
J151_04008	COG3118	belongs to the thioredoxin family
J151_04009	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J151_04010	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
J151_04011	COG0583	DNA-binding transcription factor activity
J151_04021	COG1518	maintenance of DNA repeat elements
J151_04022	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
J151_04024	COG1652	LysM domain
J151_04025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J151_04025	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J151_04026	COG1473	amidohydrolase
J151_04027	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J151_04028	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J151_04030	COG5383	Protein conserved in bacteria
J151_04038	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
J151_04039	COG3023	N-Acetylmuramoyl-L-alanine amidase
J151_04041	COG4948	Mandelate Racemase Muconate Lactonizing
J151_04043	COG0531	amino acid
J151_04046	COG4682	membrane
J151_04047	COG2133	pyrroloquinoline quinone binding
J151_04049	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J151_04050	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J151_04051	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J151_04052	COG1610	YqeY-like protein
J151_04053	COG1295	ribonuclease BN
J151_04054	COG0358	DNA primase activity
J151_04057	COG0109	protoheme IX farnesyltransferase activity
J151_04063	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
J151_04066	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J151_04076	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J151_04077	COG0739	heme binding
J151_04078	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
J151_04080	COG2223	nitrite transmembrane transporter activity
J151_04081	COG0708	Exodeoxyribonuclease III
J151_04082	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J151_04084	COG1192	Involved in chromosome partitioning
J151_04085	COG1475	DNA binding
J151_04088	COG0463	Glycosyl transferase, family 2
J151_04092	COG0756	dUTP diphosphatase activity
J151_04093	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J151_04094	COG2003	Belongs to the UPF0758 family
J151_04095	COG0018	arginyl-trna synthetase
J151_04098	COG4221	oxidoreductase activity
J151_04099	COG2755	lipolytic protein G-D-S-L family
J151_04099	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J151_04101	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J151_04102	COG1166	arginine decarboxylase activity
J151_04103	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
J151_04110	COG0606	chelatase, subunit chli
J151_04124	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J151_04133	COG0606	chelatase, subunit chli
J151_04136	COG4943	cyclic-guanylate-specific phosphodiesterase activity
J151_04145	COG1690	Belongs to the RtcB family
J151_04153	COG1090	epimerase
J151_04154	COG0745	RESPONSE REGULATOR receiver
J151_04155	COG0642	Histidine kinase
J151_04159	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J151_04164	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J151_04165	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J151_04168	COG0753	catalase activity
J151_04171	COG2197	response regulator
J151_04172	COG4585	Histidine kinase
J151_04173	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J151_04174	COG1136	(ABC) transporter
J151_04178	COG2962	Rard protein
J151_04180	COG0697	spore germination
J151_04183	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J151_04184	COG0180	Tryptophanyl-tRNA synthetase
J151_04185	COG3237	CsbD-like
J151_04193	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J151_04196	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
J151_04197	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J151_04197	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J151_04202	COG2205	protein histidine kinase activity
J151_04203	COG0745	RESPONSE REGULATOR receiver
J151_04205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J151_04209	COG1199	ATP-dependent helicase activity
J151_04212	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J151_04223	COG0625	glutathione transferase activity
J151_04230	COG4555	ABC transporter
J151_04232	COG1476	TRANSCRIPTIONal
J151_04241	COG0543	2 iron, 2 sulfur cluster binding
J151_04241	COG0633	Ferredoxin
J151_04242	COG1131	(ABC) transporter
J151_04243	COG0842	Transport permease protein
J151_04246	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
J151_04252	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J151_04253	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J151_04255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J151_04255	COG0045	succinate-CoA ligase (ADP-forming) activity
J151_04255	COG1042	CoA-binding domain protein
J151_04256	COG2239	Acts as a magnesium transporter
J151_04257	COG3338	carbonate dehydratase activity
J151_04259	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J151_04260	COG3387	PFAM Glycoside hydrolase 15-related
J151_04263	COG3100	YcgL domain-containing protein
J151_04264	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J151_04266	COG0463	Glycosyl transferase, family 2
J151_04269	COG1028	Short-chain dehydrogenase reductase Sdr
J151_04277	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J151_04280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J151_04285	COG4946	Tricorn protease homolog
J151_04285	COG1506	peptidase
J151_04285	COG0823	Involved in the tonB-independent uptake of proteins
J151_04288	COG0408	coproporphyrinogen oxidase activity
J151_04295	COG2815	serine threonine protein kinase
J151_04295	COG0515	serine threonine protein kinase
J151_04296	COG0631	protein serine/threonine phosphatase activity
J151_04303	COG3501	Rhs element vgr protein
J151_04329	COG0210	DNA helicase
J151_04331	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J151_04332	COG0583	DNA-binding transcription factor activity
J151_04333	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J151_04335	COG2159	amidohydrolase
J151_04336	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J151_04337	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J151_04339	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J151_04343	COG0357	Ribosomal RNA small subunit methyltransferase G
J151_04344	COG3540	Alkaline phosphatase
J151_04347	COG2091	lysine biosynthetic process via aminoadipic acid
J151_04350	COG0708	Exodeoxyribonuclease III
J151_04352	COG1846	Transcriptional regulator
J151_04352	COG1940	carbohydrate kinase activity
J151_04354	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J151_04356	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J151_04357	COG3162	membrane
J151_04359	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J151_04365	COG3507	Belongs to the glycosyl hydrolase 43 family
J151_04368	COG1028	Short-chain dehydrogenase reductase Sdr
J151_04369	COG0179	Fumarylacetoacetate (FAA) hydrolase
J151_04370	COG4948	Mandelate Racemase Muconate Lactonizing
J151_04372	COG3254	rhamnose metabolic process
J151_04373	COG0738	Major facilitator superfamily
J151_04374	COG1414	Transcriptional regulator
J151_04375	COG1971	Probably functions as a manganese efflux pump
J151_04376	COG2205	protein histidine kinase activity
J151_04378	COG3459	Glycosyltransferase 36 associated
J151_04379	COG2211	Major facilitator Superfamily
J151_04380	COG3265	gluconokinase activity
J151_04381	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J151_04385	COG2911	Protein conserved in bacteria
J151_04386	COG0729	surface antigen
J151_04389	COG2963	transposase activity
J151_04394	COG0752	glycyl-tRNA synthetase alpha subunit
J151_04395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J151_04397	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J151_04397	COG0519	Catalyzes the synthesis of GMP from XMP
J151_04399	COG0805	protein transport
J151_04400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J151_04401	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J151_04403	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J151_04406	COG2974	May be involved in recombination
J151_04407	COG0037	tRNA processing
J151_04408	COG2115	Belongs to the xylose isomerase family
J151_04410	COG3661	Belongs to the glycosyl hydrolase 67 family
J151_04412	COG4948	Mandelate Racemase Muconate Lactonizing
J151_04414	COG1472	Belongs to the glycosyl hydrolase 3 family
J151_04415	COG0246	Mannitol dehydrogenase
J151_04423	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J151_04424	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J151_04429	COG3386	PFAM SMP-30 Gluconolaconase
J151_04431	COG3250	beta-galactosidase activity
J151_04432	COG1904	glucuronate isomerase
J151_04433	COG3693	PFAM glycoside hydrolase, family 10
J151_04435	COG3693	PFAM glycoside hydrolase, family 10
J151_04438	COG2211	Major facilitator Superfamily
J151_04450	COG2937	Belongs to the GPAT DAPAT family
J151_04456	COG0284	orotidine-5'-phosphate decarboxylase activity
J151_04457	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
J151_04459	COG3132	Protein of unknown function, DUF480
J151_04462	COG0210	DNA helicase
J151_04463	COG1435	thymidine kinase activity
J151_04465	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
J151_04467	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J151_04474	COG3135	benzoate transporter
J151_04478	COG0676	glucose-6-phosphate 1-epimerase activity
J151_04480	COG3012	SEC-C Motif Domain Protein
J151_04481	COG0730	response to heat
J151_04485	COG0302	gtp cyclohydrolase
J151_04488	COG1566	PFAM secretion protein HlyD family protein
J151_04490	COG1289	transmembrane transporter activity
J151_04491	COG0477	Major facilitator Superfamily
J151_04493	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J151_04497	COG4691	Plasmid stability protein
J151_04498	COG1487	ribonuclease activity
J151_04503	COG0564	pseudouridine synthase activity
J151_04505	COG2963	transposase activity
J151_04509	COG0439	Biotin carboxylase
J151_04520	COG1074	ATP-dependent DNA helicase activity
J151_04521	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
J151_04523	COG1127	ABC transporter
J151_04524	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J151_04525	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J151_04528	COG2853	Lipoprotein
J151_04530	COG0386	Belongs to the glutathione peroxidase family
J151_04532	COG1322	Protein conserved in bacteria
J151_04533	COG0604	alcohol dehydrogenase
J151_04534	COG0583	DNA-binding transcription factor activity
J151_04536	COG0625	glutathione transferase activity
J151_04538	COG0531	amino acid
J151_04539	COG3537	Alpha-1,2-mannosidase
J151_04541	COG3706	GGDEF domain
J151_04542	COG3835	regulator
J151_04543	COG1929	Belongs to the glycerate kinase type-1 family
J151_04544	COG2271	Major facilitator Superfamily
J151_04547	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J151_04549	COG0861	Integral membrane protein TerC family
J151_04551	COG0584	glycerophosphoryl diester phosphodiesterase
J151_04554	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
J151_04555	COG0726	polysaccharide deacetylase
J151_04556	COG0706	membrane insertase activity
J151_04557	COG0594	ribonuclease P activity
J151_04558	COG0230	Belongs to the bacterial ribosomal protein bL34 family